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Cost analysis of radical resection of malignant breast tumors under the China Healthcare Security Diagnosis Related Groups payment system 认领 引用 被引量：4
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作者 Yun-He Hu Ai-Dong Li 《World Journal of Clinical Cases》 SCIE 2024年第20期4174-4179,共6页
BACKGROUND Breast cancer is one of the most common malignant tumors in women worldwide and poses a severe threat to their health.Therefore,this study examined patients who underwent breast cancer surgery,analyzed hosp... BACKGROUND Breast cancer is one of the most common malignant tumors in women worldwide and poses a severe threat to their health.Therefore,this study examined patients who underwent breast cancer surgery,analyzed hospitalization costs and structure,and explored the impact of China Healthcare Security Diagnosis Related Groups(CHS-DRG)management on patient costs.It aimed to provide medical institutions with ways to reduce costs,optimize cost structures,reduce patient burden,and improve service efficiency.AIM To study the CHS-DRG payment system’s impact on breast cancer surgery costs.METHODS Using the CHS-DRG(version 1.1)grouping criteria,4073 patients,who underwent the radical resection of breast malignant tumors from January to December 2023,were included in the JA29 group;1028 patients were part of the CHS-DRG payment system,unlike the rest.Through an independent sample t-test,the length of hospital stay as well as total hospitalization,medicine and consumables,medical,nursing,medical technology,and management expenses were compared.Pearson’s correlation coefficient was used to test the cost correlation.RESULTS In terms of hospitalization expenses,patients in the CHS-DRG payment group had lower medical,nursing,and management expenses than those in the diagnosis-related group(DRG)non-payment group.For patients in the DRG payment group,the factors affecting the total hospitalization cost,in descending order of relevance,were medicine and consumable costs,consumable costs,medicine costs,medical costs,medical technology costs,management costs,nursing costs,and length of hospital stay.For patients in the DRG nonpayment group,the factors affecting the total hospitalization expenses in descending order of relevance were medicines and consumable expenses,consumable expenses,medical technology expenses,the cost of medicines,medical expenses,nursing expenses,length of hospital stay,and management expenses.CONCLUSION The CHS-DRG system can help control and reduce unnecessary medical expenses by controlling medicine costs,medical consumable costs,and the length of hospital stay while ensuring medical safety. 展开更多
关键词 China Healthcare Security Diagnosis Related Groups Real-world study Radical resection of malignant breast tumors Hospitalization costs Cost structure Average length of stay
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Insulin-producing cells are bi-potential and differentiatorsprior to proliferation in early human development 认领 引用 被引量：4
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作者 Kai-Ming Yang Wang Yong +1 位作者 Ai-Dong Li Hui-Jun Yang 《World Journal of Diabetes》 2011年第4期54-58,共5页
AIM: To investigate the differentiation and migration of endocrine cells to form the pancreatic islets of Langer-hans in early human development.METHODS: Embryonic pancreas of 6-14 wk gestation was observed using immu... AIM: To investigate the differentiation and migration of endocrine cells to form the pancreatic islets of Langer-hans in early human development.METHODS: Embryonic pancreas of 6-14 wk gestation was observed using immunocytochemistry methods in early human development.RESULTS: Insulin and glucagon are expressed in the same epithelium cells in the pancreas. In addition, insulin-producing cells also secrete somatostatin in early human embryonic development and these insulin-producing cells also express nestin.CONCLUSION: Pancreatic duct epithelial cells that can produce insulin in early human development are precursors and still have the potential to differentiate other endocrine cells. These progenitors have differentiated before migration from primary ductal epithelium to form the pancreatic islets. 展开更多
关键词 Pancreatic precursor Insulin Nestin Embryonic development
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Surgical treatment of liver cancer and pancreatic cancer under the China Healthcare Security Diagnosis Related Groups payment system 认领 引用
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作者 Yun-He Hu Fan Yu +1 位作者 Yu-Zhuo Zhou Ai-Dong Li 《World Journal of Clinical Cases》 SCIE 2024年第21期4673-4679,共7页
BACKGROUND Data from the World Health Organization’s International Agency for Research on Cancer reported that China had the highest prevalence of cancer and cancer deaths in 2022.Liver and pancreatic cancers account... BACKGROUND Data from the World Health Organization’s International Agency for Research on Cancer reported that China had the highest prevalence of cancer and cancer deaths in 2022.Liver and pancreatic cancers accounted for the highest number of new cases.Real-world data(RWD)is now widely preferred to traditional clinical trials in various fields of medicine and healthcare,as the traditional research approach often involves highly selected populations and interventions and controls that are strictly regulated.Additionally,research results from the RWD match global reality better than those from traditional clinical trials.AIM To analyze the cost disparity between surgical treatments for liver and pancreatic cancer under various factors.METHODS This study analyzed RWD 1137 cases within the HB1 group(patients who underwent pancreatectomy,hepatectomy,and/or shunt surgery)in 2023.It distinguished different expenditure categories,including medical,nursing,technical,management,drug,and consumable costs.Additionally,it assessed the contribution of each expenditure category to total hospital costs and performed cross-group comparisons using the non-parametric Kruskal–Wallis test.This study used the Steel–Dwass test for post-hoc multiple comparisons and the Spearman correlation coefficient to examine the relationships between variables.RESULTS The study found that in HB11 and HB13,the total hospitalization costs were significantly higher for pancreaticoduodenectomy than for pancreatectomy and hepatectomy.Although no significant difference was observed in the length of hospital stay between patients who underwent pancreaticoduodenectomy and pancreatectomy,both were significantly longer than those who underwent liver resection.In HB15,no significant difference was observed in the total cost of hospitalization between pancreaticoduodenectomy and pancreatectomy;however,both were significantly higher than those in hepatectomy.Additionally,the length of hospital stay was significantly longer for patients who underwent pancreaticoduodenectomy than for those who underwent pancreatectomy or liver resection.CONCLUSION China Healthcare Security Diagnosis Related Groups payment system positively impacts liver and pancreatic cancer surgeries by improving medical quality and controlling costs.Further research could refine this grouping system and ensure continuous effectiveness and sustainability. 展开更多
关键词 China health care security diagnosis-related groups Real-world study Liver cancer surgical treatment Pancreatic cancer surgical treatment Hospitalization costs Cost structure Average length of stay
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ISLET FORMATION AND REGENERATION 认领 引用 被引量：6
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作者 Kai-ming Yang Ai-dong Li +3 位作者 Yan Mei Hong-ying Zhou Hua Li Hui-jun Yang 《Chinese Medical Sciences Journal》 CAS 2006年第1期27-32,共6页
Objective To explore the mechanisms of differentiation and development of pancreatic endocrine cells as well as pancreatic regeneration.Methods Human embryonic pancreatic tissue at 7-14 weeks of gestation was collecte... Objective To explore the mechanisms of differentiation and development of pancreatic endocrine cells as well as pancreatic regeneration.Methods Human embryonic pancreatic tissue at 7-14 weeks of gestation was collected.Diabetes mellitus rat model was induced with 65 mg/kg of streptozotocin.Insulin, glucagon, somatostatin, nestin, and cytokeratin 19 (CK19) of pancreatic tissues were observed by immunohistochemistry.Results At 9 weeks of gestation, pancreatic epithelial cells began to co-express insulin, glucagon, somatostatin, and CK19 before migration.Islet cells gradually congregated along with the increase of aging, and at 14 weeks of gestation histological examination showed islet formation.At 12 weeks of gestation, nestin-positive cells could be seen in the pancreatic mesenchyme.During early embryogenesis, islet cells of pancreatic ducts co-expressed insulin, glucagon, and somatostatin.During pancreatic regeneration after damage, nestin expression of islet cells increased.Conclusion In the early stage of embryogenesis, islet cells of primary pancreatic ducts can be differentiated to multipotential endocrine cells before migration.During tissue regeneration, pancreatic stem cells may differentiate and proliferate to form pancreatic islet. 展开更多
关键词 β-cells islet formation differentiation diabetic model regeneration stem cells
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