期刊文献+
任意字段
题名或关键词
题名
关键词
摘要
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息
共找到3篇文章
< 1 >
每页显示 20 50 100
已选0条
引用分析
参考文献
引证文献
 统计分析
检索结果
已选文献
显示方式：
Single-atom rhodium mimicking the oxidase and peroxidase for NADH cascade oxidation 认领 引用 被引量：1
1
作者 Hong-Jin Xue Meng Zhang +6 位作者 Yong-Qing Li Chao-Ran Liu Xin-Yu Ma Qin-Bin He Yin-Chuan Wang Jin-Xing Chen Jian-Feng Qiu 《Rare Metals》 SCIE EI CAS CSCD 2025年第6期4025-4037,共13页
Constructing high-performance nanozymes for specific biomolecules is crucial but challenging for practical applications and fundamental research.Herein,through the examination of the catalytic reaction paths of natura... Constructing high-performance nanozymes for specific biomolecules is crucial but challenging for practical applications and fundamental research.Herein,through the examination of the catalytic reaction paths of natural nicotinamide adenine dinucleotide(NADH)oxidase(NOX),a novel and efficient single-atom rhodium catalyst(Rh1/NC)was developed to mimic NOX.The Rh1/NC demonstrated the ability to catalyze the dehydrogenation of NADH and transfer electrons to O2to generate H2O2through the typical two-electron pathway.Furthermore,our findings revealed that Rh1/NC exhibits the ability to catalyze the conversion of produced H2O2into OH under mildly acidic conditions.This process amplifies the oxidation of NADH,showcasing NADH peroxidase-like activity(NPx-like).As a paradigm,this unique dual enzyme-like property of Rh1/NC with a positive feedback effect holds significance in disrupting cancer cellular homeostasis.Rh1/NC can effectively consume NADH via cascade biocatalytic reactions within cancer cells,further triggering the elevation of reactive oxygen species(ROS),leading to impaired oxidative phosphorylation and decreased mitochondrial membrane potential,thus damaging the adenosine triphosphate(ATP)synthesis.The resulting'domino effect'interferes with the energy metabolism homeostasis of cancer cells,ultimately promoting cell apoptosis.This study provides potential guidance for the rational design of materials with greater capabilities. 展开更多
关键词 NADH oxidase mimetics Single-atom nanozymes Cascade biocatalytic reactions Positive feedback Cell apoptosis
暂未订购 下载PDF
Group-specific component and 25-hydroxylase gene polymorphisms in nasopharyngeal carcinoma:Associations with susceptibility and radiotherapy response 认领 引用
2
作者 Liu Liu Dian-Yu Shi +2 位作者 Jie Tan Shan Xu Chao-Ran Liu 《World Journal of Clinical Oncology》 2025年第12期118-129,共12页
BACKGROUND Nasopharyngeal carcinoma(NPC),exhibiting high incidence in southern China,is linked to genetic and environmental factors.Vitamin D metabolism,involving transport[group-specific component(GC)protein]and acti... BACKGROUND Nasopharyngeal carcinoma(NPC),exhibiting high incidence in southern China,is linked to genetic and environmental factors.Vitamin D metabolism,involving transport[group-specific component(GC)protein]and activation[25-hydroxylase(CYP2R1)enzyme],may influence NPC susceptibility and radiotherapy response.Polymorphisms in GC and CYP2R1 genes affect protein function and serum 25-hydroxyvitamin D[25(OH)D]levels,and are implicated in other cancers.However,their role in NPC-particularly in high-risk Han Chinese populations-and interaction with vitamin D status remains unclear.This case control study(360 NPC patients,550 controls)investigates these relationships to inform prevention and personalized therapy.AIM To investigate the association between vitamin D binding protein(GC)and CYP2R1 gene polymorphisms with susceptibility to NPC and radiotherapy response.METHODS A case control study design was adopted,and 360 patients with NPC and 550 healthy controls were included.TaqMan method was used to perform genotyping on GC gene loci rs4588,rs7041,and CYP2R1 gene loci rs10741657,rs12794714.Serum 25(OH)D levels were detected,and the relationship between gene polymorphisms and NPC risk and radiotherapy response was analyzed.RESULTS The GC gene rs4588 TT genotype was significantly associated with the risk of NPC in both the codominant model[odds ratio(OR)=1.68,95%CI:1.15-2.45,P=0.007]and the recessive model(OR=1.56,95%CI:1.02-2.38,P=0.039).The association between the rs4588 TT genotype and the risk of NPC was more significant in the male subgroup(OR=1.87,95%CI:1.11-3.15,P=0.019)and the squamous cell carcinoma subgroup(OR=1.89,95%CI:1.19-3.00,P=0.007).The serum 25(OH)D level of the rs7041 AA genotype carriers was significantly lower than that of the CC genotype(P<0.001).The CYP2R1 gene rs10741657 AA genotype was associated with higher serum 25(OH)D levels(P=0.003).The rs12794714 AA genotype was associated with radiotherapy resistance(OR=1.76,95%CI:1.18-2.63,P=0.005).Stratified analysis showed that the association between rs4588 and rs12794714 was significant only in the subgroup with higher 25(OH)D levels.CONCLUSION GC and CYP2R1 genes polymorphisms are associated with NPC susceptibility and radiotherapy response,and this association may be affected by serum 25(OH)D levels.This study provides a new idea for the prevention and individualized treatment in NPC. 展开更多
关键词 Group-specific component protein 25-hydroxylase Single nucleotide polymorphism Nasopharyngeal carcinoma Susceptibility Radiotherapy response
暂未订购 下载PDF
Zircon U-Pb age evidence of the Mesoarchean(2.9–3.2 Ga)crustal remnant in the Southern Dabie Orogen,South China 认领 引用 被引量：2
3
作者 Da-liang Xu Lian-hong Peng +3 位作者 Xin Deng Chao-ran Liu Le Wan Xiao-ming Zhao 《China Geology》 CAS CSCD 2023年第1期174-176,共3页
1.Objective Unlike the North China Plate where Archean and Paleoproterozoic crustal rocks are widely distributed,Early Precambrian basement rocks in the Yangtze Block of South China are locally exposed(Fig.1a),such as... 1.Objective Unlike the North China Plate where Archean and Paleoproterozoic crustal rocks are widely distributed,Early Precambrian basement rocks in the Yangtze Block of South China are locally exposed(Fig.1a),such as in the Kongling Complex,the Zhongxiang Complex,and the Douling Complex(Zhao GC and Cawood PA,2012).The Dabie Orogen is the eastward extension of the Qinling Orogen. 展开更多
关键词 crustal Dabie South
暂未订购 下载PDF
已选0条
引用分析
参考文献
引证文献
 统计分析
检索结果
已选文献
上一页 1 下一页 到第 页
在线咨询 使用帮助 返回顶部 意见反馈