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Coping with extremes:diet and phylogeny shape gut microbiota in six passerine species inhabiting the Qinghai-Tibet Plateau 认领 引用
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作者 Yanfeng Sun Xu Liu +8 位作者 Qian Zhang Mo Li Lirong Zuo Fangyuan Liu Dandan Ma Yang Wang Limin Wang Yaotong Hao Dongming Li 《Avian Research》 SCIE CAS CSCD 2026年第1期123-133,共11页
Understanding how diet and host phylogeny shape gut microbiota is fundamental to elucidating host-microbe interactions in extreme environments.The Qinghai-Tibet Plateau(QTP),characterized by harsh conditions,provides ... Understanding how diet and host phylogeny shape gut microbiota is fundamental to elucidating host-microbe interactions in extreme environments.The Qinghai-Tibet Plateau(QTP),characterized by harsh conditions,provides a natural laboratory for examining these relationships among sympatric species.Here,we investigated the dietary composition and gut microbiota of six passerine species inhabiting the QTP,comprising two endemic residents(White-rumped Snowfinch Onychostruthus taczanowskii and Ground Tit Pseudopodoces humilis),two nonendemic residents(Rock Sparrow Petronia petronia and Eurasian Tree Sparrow Passer montanus),and two nonendemic migratory species(Twite Linaria flavirostris and Black Redstart Phoenicurus ochruros),using highthroughput 18S and 16S rRNA sequencing.Our results revealed that dietary composition—dominated by Archaeplastida,Metazoa,Fungi,and the SAR supergroup—exhibited no significant interspecific variation,reflecting a high degree of trophic niche overlap.Although the overall diet was similar across species,the relative abundances of certain dietary components independently influenced specific microbial taxa.In particular,dietary Archaeplastida and Fungi showed phylogeny-independent positive correlations with 16 and 3 microbial genera,respectively,revealing fine-scale diet-microbiota associations.Evidence of phylosymbiosis was detected,as closely related species harbored more similar microbial communities driven by species-specific microbial biomarkers.Notably,our results suggested deterministic processes played a stronger role in endemic species,whereas stochastic community assembly dominated in non-endemic species,indicating distinct assembly mechanisms shaped by biogeographic history.Overall,this study reveals that while dietary similarity promotes convergent trophic niches among sympatric passerines,host phylogeny exerts a stronger influence on gut microbiota composition and assembly.These findings underline the synergistic roles of diet-microbiota interactions and phylosymbiosis dynamics as key adaptive strategies that enable birds to cope with the extreme environments of the QTP. 展开更多
关键词 Dietary components Gut microbiota Host phylogeny Sympatric birds Qinghai-Tibet Plateau
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Nanostructural determinants of angle-dependent iridescent coloration in two peafowl species 认领 引用
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作者 Fangyuan Liu Xu Liu +10 位作者 Lirong Zuo Jie Wang Jinming Zhou Limin Wang Yuhong Hu Feng Dong Dandan Ma Gang Feng Yongbin Zhang Yang Wang Dongming Li 《Avian Research》 SCIE CAS CSCD 2026年第3期754-763,共10页
Structural colors arise from light interacting with nanoscale architectures,yet the relationships between multiple nanostructural features and their optical properties remain poorly understood.Peafowl feathers,iconic ... Structural colors arise from light interacting with nanoscale architectures,yet the relationships between multiple nanostructural features and their optical properties remain poorly understood.Peafowl feathers,iconic exemplars of iridescent coloration,feature photonic-crystal architectures that exhibit diverse hues.Here,we analyzed angle-dependent optical properties and seven key nanostructural parameters in different body feathers of male Indian Peafowl(Pavo cristatus)and Green Peafowl(P.muticus).Our findings revealed position-specific divergences in melanosome arrangement among neck,back,and wing feathers,resulting in distinct spectral signatures critical for speciation.Conversely,eyespots on upper tail coverts showed conserved optical properties in both species,achieved through distinct nanoscale organizations and illustrating optical degeneracy—different architectures result in the same appearance.Using a piecewise structural equation model,we established a predictive network linking seven parameters to four color properties—hue and brightness—across two illumination angles.Results elucidated a hierarchical framework where nanostructural parameters influence angledependent coloration via variation in melanosome layers,medullary width,and lattice spacing.Finally,color traits were influenced by angle-dependent changes in hue and brightness,as well as by layer number,melanosome rod length,and radius.Collectively,our findings provide a robust predictive framework linking nanostructure to optical phenotype and highlight the evolutionary significance of optical degeneracy for maintaining reliable sexual signals in birds. 展开更多
关键词 Iridescence Melanosome Peafowl Photonic-crystal Species variation Structural color
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Ecological and behavioral dimensions of coexistence in two understory babblers in Subtropical China 认领 引用
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作者 Zhengzhen Wang Fangyuan Liu +1 位作者 Wei Yang Fasheng Zou 《Current Zoology》 SCIE CAS CSCD 2026年第1期81-94,共14页
Species coexistence is pivotal for ecological balance and is shaped by resource dynamics and evolutionary processes.It is generally believed that a certain degree of niche overlap is beneficial for the integrity and e... Species coexistence is pivotal for ecological balance and is shaped by resource dynamics and evolutionary processes.It is generally believed that a certain degree of niche overlap is beneficial for the integrity and efficiency of mixed-species foraging flocks(MSFs)in birds,whereas the coexistence of species requires niche divergence as a fundamental prerequisite.To navigate the paradox of coexistence against the backdrop of MSFs is crucial for understanding avian biodiversity.Here,we took the angle from home ranges to address this question.VHF telemetry tracking was conducted on two widely coexisting understory birds of the mixed-species flocks,the David’s fulvetta(Alcippe davidi)and the Streak-breasted scimitar babbler(Pomatorhinus ruficollis)in subtropical Central China to investigate their spatial interactions during breeding season.Our research revealed significantly greater intraspecific home range overlap(0.376)in the fulvettas than in the scimitar babblers(0.213),which suggests differentiation in intraspecies gregariousness.Further scrutiny of habitat preferences revealed that scimitar babblers had significantly high tolerances to barren lands and croplands.Both species maintained similar home range sizes and foraging timings and paces.Our research underscores the importance of intrinsic gregariousness and convergent land cover type preferences in MSFs albeit other diverging characteristics in the breeding season. 展开更多
关键词 ecological niche home range mixed-species flock species coexistence VHF radiotelemetry
Unravelling sorghum functional genomics and molecular breeding:past achievements and future prospects 认领 引用
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作者 Fangyuan Liu Baye Wodajo +3 位作者 Kangxu Zhao Sanyuan Tang Qi Xie Peng Xie 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2025年第6期719-732,共14页
Sorghum,renowned for its substantial biomass production and remarkable tolerance to various stresses,possesses extensive gene resources and phenotypic variations.A comprehensive understanding of the genetic basis unde... Sorghum,renowned for its substantial biomass production and remarkable tolerance to various stresses,possesses extensive gene resources and phenotypic variations.A comprehensive understanding of the genetic basis underlying complex agronomic traits is essential for unlocking the potential of sorghum in addressing food and feed security and utilizing marginal lands.In this context,we provide an overview of the major trends in genomic resource studies focusing on key agronomic traits over the past decade,accompanied by a summary of functional genomic platforms.We also delve into the molecular functions and regulatory networks of impactful genes for important agricultural traits.Lastly,we discuss and synthesize the current challenges and prospects for advancing molecular design breeding by gene-editing and polymerization of the excellent alleles,with the aim of accelerating the development of desired sorghum varieties. 展开更多
关键词 Sorghum Genomic resource Multi-omics Genotype-to-phenotype Domestication Environmental adaptation Design breeding
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Genetic variants and mRNA expression levels of KLF4 and KLF5 with hypertension:A combination of case-control study and cohort study 认领 引用
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作者 Xu Han Wen Li +10 位作者 Changying Chen Jiahui Liu Junxiang Sun Feifan Wang Chao Wang Jialing Mu Xincheng Gu Fangyuan Liu Hankun Xie Song Yang Chong Shen 《Journal of Biomedical Research》 CAS CSCD 2025年第1期103-113,共11页
Hypertension(HT)is a major risk factor for cardiovascular diseases.Krüppel-like factors(KLFs)are important transcription factors in eukaryotes.Studies have reported that KLF4 and KLF5 are correlated with several ... Hypertension(HT)is a major risk factor for cardiovascular diseases.Krüppel-like factors(KLFs)are important transcription factors in eukaryotes.Studies have reported that KLF4 and KLF5 are correlated with several cardiovascular diseases,but population-based studies on associations between HT and KLF4 or KLF5 have rarely been reported.Therefore,the current study investigated the associations of genetic variants and m RNA expression levels of KLF4 and KLF5 with HT,as well as the effects of antihypertensive drugs on the expression levels of these genes.The associations of one single-nucleotide polymorphism(SNP)in KLF4 and three SNPs in KLF5with HT were analyzed using a combination of case-control and cohort studies.The study populations were selected from a community-based cohort in four regions of Jiangsu province.The risks of HT were estimated through logistic and Cox regression analyses.In addition,m RNA expression levels of KLF4 and KLF5 were detected in 246 controls and 385 HT cases selected from the aforementioned cohort.Among the HT cases,263were not taking antihypertensive drugs[AHD(-)]and 122 were taking antihypertensive drugs[AHD(+)].In the case-control study,SNP rs9573096(C>T)in KLF5 was significantly associated with an increased risk of HT in the additive model(adjusted odds ratio[OR],1.106;95%confidence interval[CI],1.009 to 1.212).In the cohort study of the normotensive population,rs9573096 in KLF5 was also significantly associated with an increased risk of HT in the additive model(adjusted hazards ratio[HR],1.199;95%CI,1.070 to 1.344).KLF4 and KLF5m RNA expression levels were significantly higher in the AHD(-)group than in the control group(P<0.05),but lower in the AHD(+)group than in the AHD(-)group(P<0.05).The current study demonstrated the associations of KLF4 and KLF5 genetic variants with hypertension,as well as the association of the indicative variations in m RNA expression levels of KLF4 and KLF5 with the risk of hypertension and antihypertensive treatment. 展开更多
关键词 hypertension KLF4 KLF5 single-nucleotide polymorphism mRNA expression antihypertensive drugs
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Amorphous Iridium Oxide-Integrated Anode Electrodes with Ultrahigh Material Utilization for Hydrogen Production at Industrial Current Densities 认领 引用 被引量：4
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作者 Lei Ding Kui Li +10 位作者 Weitian Wang Zhiqiang Xie Shule Yu Haoran Yu David ACullen Alex Keane Kathy Ayers Christopher BCapuano Fangyuan Liu Pu-Xian Gao Feng-Yuan Zhang 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第10期225-239,共15页
Herein,ionomer-free amorphous iridium oxide(IrOx)thin electrodes are first developed as highly active anodes for proton exchange membrane electrolyzer cells(PEMECs)via low-cost,environmentally friendly,and easily s... Herein,ionomer-free amorphous iridium oxide(IrOx)thin electrodes are first developed as highly active anodes for proton exchange membrane electrolyzer cells(PEMECs)via low-cost,environmentally friendly,and easily scalable electrodeposition at room temperature.Combined with a Nafion 117 membrane,the IrOx-integrated electrode with an ultralow loading of 0.075 mg cm-2delivers a high cell efficiency of about 90%,achieving more than 96%catalyst savings and 42-fold higher catalyst utilization compared to commercial catalyst-coated membrane(2 mg cm-2).Additionally,the IrOxelectrode demonstrates superior performance,higher catalyst utilization and significantly simplified fabrication with easy scalability compared with the most previously reported anodes.Notably,the remarkable performance could be mainly due to the amorphous phase property,sufficient Ir3+content,and rich surface hydroxide groups in catalysts.Overall,due to the high activity,high cell efficiency,an economical,greatly simplified and easily scalable fabrication process,and ultrahigh material utilization,the IrOxelectrode shows great potential to be applied in industry and accelerates the commercialization of PEMECs and renewable energy evolution. 展开更多
关键词 Ionomer-free Amorphous IrOx electrodes Ultrahigh material utilization Scalable electrodeposition Hydrogen production
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Experimental study on the jet characteristics of a steam plasma torch 认领 引用 被引量：2
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作者 Fangyuan LIU Deping YU +3 位作者 Cheng LV Yazhou DUAN Yanjie ZHONG Jin YAO 《Plasma Science and Technology》 SCIE EI CAS CSCD 2018年第12期47-55,共9页
Thermal steam plasma jet is promising for applications in environmental industries due to its distinctive characteristics of high enthalpy and high chemical reactivity.However,the performance of the steam plasma torch... Thermal steam plasma jet is promising for applications in environmental industries due to its distinctive characteristics of high enthalpy and high chemical reactivity.However,the performance of the steam plasma torch for its generation is limited by the problems of the large arc voltage fluctuation and serious erosion of the electrodes.In this study,a gas-stabilized steam plasma torch which can operate continuously and stably was designed.Experiments were conducted to reveal the effect of the different working parameters,including the anode diameter,the cooling water temperature,the arc current and the steam flow rate,on its Volt-Ampere characteristics,arc voltage fluctuation,thermal efficiency,jet characteristics and electrodes erosion.Results showed that the use of hot water to cool the electrodes can effectively prevent the condensation of steam on the inner wall of the electrodes,thus significantly reducing the arc voltage fluctuations and electrodes erosion.This is crucial for increasing the working life of the electrodes and ensuring long-term stability of the steam plasma torch.In addition,suitable anode diameter can greatly reduce the arc voltage fluctuation of the steam plasma torch and effectively improve the stability of the steam plasma jet.Furthermore,high arc current can effectively reduce the fluctuations of the arc voltage and increase the length and the volume of the steam plasma jet.Finally,using steam as the plasma forming gas can achieve higher thermal efficiency compared to air.An ideal thermal efficiency can be achieved by properly reducing the arc current and increasing the steam flow rate. 展开更多
关键词 steam plasma torch Volt-Ampere characteristics jet characteristics arc voltage fluctuation electrode erosion
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Conspecific nest-raiding directs more at dominant breeders in the azure-winged magpie 认领 引用 被引量：2
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作者 Lifang GAO Xiaodan ZHANG +6 位作者 Tianchang YANG Shaoxue WANG Qian WANG Fangyuan LIU Zhenqin ZHU Shumei ZI Bo DU 《Current Zoology》 SCIE CAS CSCD 2022年第6期734-736,共3页
Conspecific animals in the wild use limited resources—such as food,nest site,and mating opportunities—very differently(Shuster and Wade 2003),which has been widely considered a consequence of phenotypic diversity(Sh... Conspecific animals in the wild use limited resources—such as food,nest site,and mating opportunities—very differently(Shuster and Wade 2003),which has been widely considered a consequence of phenotypic diversity(Shuster 2010). 展开更多
关键词 breed specific consequence
Detoxification strategy of Microcystis aeruginosa to the toxicity of Cd(Ⅱ):role of EPS in alleviating toxicity 认领 引用 被引量：1
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作者 Xingye HAN Fangyuan LIU +3 位作者 Yibo ZHANG Kai CHENG Heyun WANG Hongmei GE 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2024年第3期802-815,共14页
Although many studies have found that cadmium(Cd)can be toxic to microalgae,only a few reports focused on the role of extracellular polymeric substances(EPS)in Cd(Ⅱ)detoxification.The biochemical and physiological en... Although many studies have found that cadmium(Cd)can be toxic to microalgae,only a few reports focused on the role of extracellular polymeric substances(EPS)in Cd(Ⅱ)detoxification.The biochemical and physiological endpoints of Microcystis aeruginosa,including the composition and functional groups of soluble EPS(SL-EPS),loosely bound EPS(LB-EPS),and tightly bound EPS(TB-EPS),were detected to elucidate the toxicity and detoxification mechanisms of Cd(Ⅱ)for cyanobacteria.Toxicological and physiological assays on M.aeruginosa showed that the 0.25-mg/L Cd(Ⅱ)resulted in a larger inhibition on growth and Fv/Fm.Nevertheless,Cd(Ⅱ)significantly induced much higher contents of superoxide dismutase(SOD),intracellular microcystin LR(MC-LR),extracellular MC-LR,and EPS.Scanning electron microscopy with energy dispersive X-ray spectroscopy confirmed that Cd(Ⅱ)was absorbed into the EPS layer.Fourier transform infrared spectrum analysis revealed that the functional groups bound with Cd(Ⅱ)of algae biomass,SL-EPS,LB-EPS,and TB-EPS were somewhat different.The C=O/C=N groups ofδ-lactam or protein were their prominent functional groups,suggesting that amide or proteins in the EPS played a key role in the adsorption in Cd(Ⅱ).The concentration of 0.25 mg/L of Cd(Ⅱ)may change the chemical structure of EPS by altering the production of protein-like substances containing tryptophan.This study indicated that M.aeruginosa could detoxify Cd(Ⅱ)stress via induction of antioxidant capacity(higher SOD activity and MC synthesis),EPS production,and modification in chemical structure of EPS. 展开更多
关键词 Microcystis aeruginosa cadmium extracellular polymeric substances(EPS) microcystin detoxification
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Responses of a resident group to an outsider in the blue-breasted quail: A paradigm for studying social resettlement of dispersers 认领 引用
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作者 Shumei Zi Lifang Gao +4 位作者 Xiaoxue Chen Qian Wang Fangyuan Liu Jianchuan Li Bo Du 《Current Zoology》 SCIE CAS CSCD 2023年第3期236-243,共8页
Dispersal is an individual life-history trait that can influence the ecological and evolutionary dynamics of both the source and recipient populations.Current studies of animal dispersal have paid little attention to ... Dispersal is an individual life-history trait that can influence the ecological and evolutionary dynamics of both the source and recipient populations.Current studies of animal dispersal have paid little attention to how the responses of residents in a recipient population affect the social resettlement of dispersers into a new habitat.We addressed this question in the blue-breasted quail Synoicus chinensis by designing an outsider introduction experiment to simulate a scenario of interaction between residents and dispersers.In the experiment,we introduced an unfamiliar quail into a group of 3 differently ranked residents and then examined their behavioral responses to the arrival of the outsider.We found that all residents made negative responses by pecking at the outsider to maintain their pecking order,in which high-ranked residents displayed significantly greater intensity than those of lower ranks.This result highlighted that adverse behavioral responses of residents would prevent outsiders from obtaining hierarchical dominance in the recipient group.Moreover,the residents’sex ratio,their relative ages to the outsiders,and whether outsiders counter-pecked at the residents all influenced the probability of outsiders prevailing against the residents.Those outsiders that displayed counter-peck courage were more likely to gain higher dominance and hence resettle into the recipient group successfully.Our findings suggest that resident groups may impose a selection among dispersers via adverse behavioral responses.Therefore,social factors that can influence the resettlement step of dispersers in a new habitat should be accounted for in future studies of animal dispersal. 展开更多
关键词 dispersal pecking order recipient population resident group Synoicus chinensis
Some Important Properties of Multiple G-Ito Integral in the G-Expectation Space 认领 引用 被引量：1
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作者 Fangyuan Liu 《Journal of Applied Mathematics and Physics》 2018年第11期2219-2226,共8页
In the G-expectation space, we propose the multiple It&#244;?integral, which is driven by multi-dimensional G-Brownian motion. We prove the recursive relationship of multiple G-It&#244;?integrals by G-It&#... In the G-expectation space, we propose the multiple It&#244;?integral, which is driven by multi-dimensional G-Brownian motion. We prove the recursive relationship of multiple G-It&#244;?integrals by G-It&#244;formula and mathematical induction, and we obtain some computational formulas for a kind of multiple G-It&#244;?integrals. 展开更多
关键词 G-Brownian Motion Multiple G-Ito Integrals G-Ito Formula Recursive Relationship
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Multiple G-Stratonovich Integral Driven by G-Brownian Motion 认领 引用
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作者 Zou Li Fangyuan Liu 《Journal of Applied Mathematics and Physics》 2018年第11期2295-2301,共7页
In this paper, we propose the multiple Stratonovich integral driven by G-Brownian motion under the G-expectation framework. Then based on G-It&#246;formula, we obtain the relationship between Hermite polynomials a... In this paper, we propose the multiple Stratonovich integral driven by G-Brownian motion under the G-expectation framework. Then based on G-It&#246;formula, we obtain the relationship between Hermite polynomials and multiple G-Stratonovich integrals by using mathematical induction method. 展开更多
关键词 G-Stratonovich Integral G-Brownian Motion Mathematical Induction
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A Research on Business Information System and Informatization 认领 引用
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作者 Fangyuan Liu 《Proceedings of Business and Economic Studies》 2021年第4期238-240,共3页
Based on the analysis of commercial economic informatization,this paper puts forward the abstract model of commercial information system,which comprises of the environmental system,business system,monitoring system,an... Based on the analysis of commercial economic informatization,this paper puts forward the abstract model of commercial information system,which comprises of the environmental system,business system,monitoring system,and emergency system.In addition,it also involves the strain cycle,monitoring cycle,and business cycle.In order to promote a better development in the business economic model under the background of informatization,commercial enterprises should improve their understanding,develop and continuously optimize business economic informatization,as well as create an efficient and safe network security environment for the future. 展开更多
关键词 Business economic informatization Business information system Informatization Business economic model
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注意偏向矫正训练对强迫症的干预 认领 引用 被引量：1
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作者 刘方圆 张仲明 《心理学进展》 2018年第3期431-441,共11页
强迫症对不相关的信息的抑制困难表现为强迫性思维和冲动,其注意偏向会导致侵入性强迫思维的发病和维持。近年来有大量研究开始探索注意偏向矫正训练对个体注意偏向的影响效应。本文系统地阐述了强迫症个体的注意偏向特点和相关理论,以... 强迫症对不相关的信息的抑制困难表现为强迫性思维和冲动,其注意偏向会导致侵入性强迫思维的发病和维持。近年来有大量研究开始探索注意偏向矫正训练对个体注意偏向的影响效应。本文系统地阐述了强迫症个体的注意偏向特点和相关理论,以及注意偏向矫正训练的主要范式和干预效果,通过前人研究的分析总结,对未来的研究将注意偏向矫正训练运用于强迫症进行了展望。 展开更多
关键词 注意偏向矫正 强迫症 注意偏向
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Natural variations in Multi-Grain Spikelet 1 enhance grain number in sorghum 认领 引用 被引量：2
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作者 Dan Zhang Sanyuan Tang +6 位作者 Fangyuan Liu Kangxu Zhao Chao Li Ran Xia Feifei Yu Qi Xie Peng Xie 《Journal of Integrative Plant Biology》 SCIE CAS CSCD 2025年第6期1441-1443,共3页
Spikelets are the basic unit of the inflorescence in crops, consisting of one or more florets, playing a key role in determining yield. During cereal flower development, the spikelet meristem (SM) arises from the infl... Spikelets are the basic unit of the inflorescence in crops, consisting of one or more florets, playing a key role in determining yield. During cereal flower development, the spikelet meristem (SM) arises from the inflorescence meristem or branch meristem, and subsequently gives rise to the floret meristem (FM) (Xie et al., 2023). The multi-ovary or multi-floret spikelet phenomenon is commonly observed in certain cereal germplasms (Zhu et al., 2019;Ren et al., 2020;Selva et al., 2023), demonstrating the potential for enhancing grain yield through the production of a larger number of grains. A typical sorghum spikelet produces a single fertile floret, resulting in a single-grain spikelet morphology. However, the multiple-grain spikelet (MGS) sorghum germplasm, first documented in 1936, contains more than half of the double-grain spikelets per panicle and exhibits an unusual spikelet architecture in which two mature grains are produced within a single spikelet (Karper and Stephens, 1936). Despite this, the genetic basis underlying this trait has remained unclear. 展开更多
关键词 multi grain spikelet spikelet meristem natural variations floret meristem inflorescence meristem cereal germplasms one more florets branch meristem
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Experimental study of the circular subsonic pipe jet expanding into near vacuum environment 认领 引用 被引量：2
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作者 Xin Chen Fangyuan Liu +8 位作者 Yu-Ze Wang Si-Yu Zhang Qingxiang Li Jian-Zhao Wu Bo-Fu Wang Kai Leong Chong Cheng Wang Jian-Hua Zhang Quan Zhou 《Science China(Physics,Mechanics & Astronomy)》 SCIE EI CSCD 2025年第9期16-26,共11页
In extreme ultraviolet(EUV)lithography,mitigation of tin(Sn)debris contamination during EUV light generation is an important issue.In practice,the high-speed jet flows are used to transport debris away from the collec... In extreme ultraviolet(EUV)lithography,mitigation of tin(Sn)debris contamination during EUV light generation is an important issue.In practice,the high-speed jet flows are used to transport debris away from the collector mirror,thereby protecting it and improving system performance.Since EUV light is generated in a near-vacuum environment,understanding jet flow behavior in these extreme conditions is crucial for effective contamination control.In this study,we introduce a new facility designed to investigate jet extruded into near-vacuum environments using particle image velocimetry(PIV)and particle tracking velocimetry(PTV).Our results reveal a significantly extended potential core and a“top-hat”velocity profile with an inlet flow rate of 0.28 standard liter per minute(SLPM)and ambient pressure of 13.9 Pa.We also investigate the effects of inlet flow rate,ambient pressure,and jet diameter on the centerline streamwise velocity of the jet flow.These findings aim to guide the design of equipment operating in vacuum conditions. 展开更多
关键词 jet flow vacuum PIV PTV
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MicroRNA-20a-5p regulates the epithelial-mesenchymal transition of human hepatocellular carcinoma by targeting RUNX3 认领 引用 被引量：3
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作者 Xianjue Wang Ping Wei +4 位作者 Ling Yang Fangyuan Liu Xin Tong Xiaoyu Yang Liya Su 《Chinese Medical Journal》 SCIE CAS CSCD 2022年第17期2089-2097,共9页
Background::MicroRNA-20a (miR-20a) is dysregulated in many types of malignancies, including human hepatocellular carcinoma (HCC), but its expression level and functional significance in HCC are still disputed. We aime... Background::MicroRNA-20a (miR-20a) is dysregulated in many types of malignancies, including human hepatocellular carcinoma (HCC), but its expression level and functional significance in HCC are still disputed. We aimed to study the role of miR-20a-5p in HCC and its downstream molecular mechanisms.Methods::We used real-time polymerase chain reaction to detect the expression of miR-20a-5p and runt-related transcription factor 3 ( RUNX3) in HCC and paraneoplastic tissue, transfected Huh7 and highly metastatic human hepatocellular carcinoma (MHCC97H) cells. A live cell workstation was used to observe the proliferation and migration of transfected cells. The invasiveness of transfected cells was verified by Transwell assay. Cell apoptosis was detected by flow cytometry. The expression levels of proteins after transfection were measured using simple western immunoblot measurements. Gene expression profiles between HCC and normal samples were obtained from The Cancer Genome Atlas. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment results were processed by the database for annotation, visualization and integrated discovery. Potential target genes of miR-20a-5p were predicted to further investigate how miR-20a-5p regulates epithelial-mesenchymal transition (EMT) in HCC. Results::MiR-20a-5p was significantly highly expressed in HCC tissues, and overexpression of miR-20a-5p significantly promoted HCC cell proliferation, migration, and invasion and inhibited apoptosis in vitro. The protein expression of E-cadherin was decreased and that of vimentin was increased after overexpression of miR-20a-5p in HCC cells. We discovered the intersection of genes from miRDB, miR TarBase, and TargetScan, obtained 397 target genes and finally focused on RUNX3. RUNX3 was not only reduced in HCC specimens but also drastically reduced in HCC cells overexpressing miR-20a-5p. RUNX3 expression decreased with elevated miR-20a-5p, which activated downstream EMT signaling and promoted cell proliferation, migration, and invasion. Conclusions::Since RUNX3 is involved in EMT in HCC, as proven by previous research, our findings provide further evidence for a novel regulatory pathway comprising the miR-20a/RUNX3/EMT axis that upregulates EMT signaling and enhances the migration of HCC cells. 展开更多
关键词 Epithelial-mesenchymal transition Hepatocellular carcinoma miR-20a-5p RUNX3
An effective poly(p-phenylenevinylene) polymer adhesion route toward three-dimensional nitrogen-doped carbon nanotube/reduced graphene oxide composite for direct electrocatalytic oxygen reduction 认领 引用 被引量：3
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作者 Yu Fu Chungui Tian +3 位作者 Fangyuan Liu Lei Wang Haijing Yan Bai Yang 《Nano Research》 SCIE EI CSCD 2016年第11期3364-3376,共13页
Heteroatom-doped nanocarbons have excellent potential for use in the oxygen reduction reaction （ORR）. However, construction of three-dimensional （3D） N-doped carbon materials with good electrocatalytic performance... Heteroatom-doped nanocarbons have excellent potential for use in the oxygen reduction reaction （ORR）. However, construction of three-dimensional （3D） N-doped carbon materials with good electrocatalytic performance remains a challenge. Herein, a poly（p-phenylenevinylene） （PPV）-precursor adhesion route was developed for construction of 3D N-doped reduced graphene oxide-PPV calcined-carbon nanotubes （N-RGO-PPV（c）-CNTs）. In the synthesis, the PPV- precursor plays the role of a ＂glue＂ for strong adhesion of the RGO and CNTs. At high temperature, PPV can undergo transformation from the glassy state to a viscous state. Thus, the N-RGO-PPV（c）-CNT composite with multi-porous structure and ridge-like folded graphene flakes could be formed during nitridation at high temperature, which was favorable for production of more active sites for the ORR. As an ORR catalyst, the N-RGO-PPV（c）-CNT composites exhibited superior catalytic activity in alkaline electrolyte. The obtained onset potential （Eonset） of 0.92 V and catalytic current density of 5.7 mA·cm^-2 at 0.6 V （vs. RHE） are comparable to those of the 20% Pt/C composite （0.98 V and 5.2 mA·cm^-2）. The electron transfer number for the N-RGO-PPV（c）-CNT catalyst was about 3.99, which is close to that of the 20% Pt/C （4.01） catalyst. Notably, the optimal N-RGO-PPV（c）-CNT catalyst shows better durability and methanol tolerance than commercial 20% Pt/C. The good performance of the N-RGO-PPV（c）-CNT catalyst for the ORR may be attributed to the synergistic effects of the unique 3D structure for effective mass-transfer, the effective N-doping for production of more active sites, and the good contact between the RGO and CNTs for easy charge-transfer. 展开更多
关键词 three dimensionalgraphene/carbonnanotube nitrogen-doped electrocatalysis oxygen reduction
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Printable microlaser arrays with programmable modes for information encryption 认领 引用 被引量：2
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作者 Jun Ruan Dan Guo +3 位作者 Kun Ge Zhiyang Xu Fangyuan Liu Tianrui Zhai 《Nano Research》 SCIE EI CSCD 2023年第7期10100-10107,共8页
Lasing emissions with multiple and tunable modes are promising in coding field as a novel cryptographic primitive.With the advantages of simple fabrication,full-color and high-quality-factor whispering gallery mode la... Lasing emissions with multiple and tunable modes are promising in coding field as a novel cryptographic primitive.With the advantages of simple fabrication,full-color and high-quality-factor whispering gallery mode lasing inside a circular cross-section,polymer microfibers are attractive for photonic devices.However,polymer lasing microfibers for information encryption have never been reported.Herein,we propose a design of printable lasing microfiber encryption chip by in-situ tuning the effective refractive index of the microresonator arrays via a facile approach.Through inkjet printing high-refractive-index nanoparticles on the designated position of lasing microfiber arrays,the effective refractive index of the microcavities is regulated,and the ratio of wavenumber spacing between transverse electric and transverse magnetic mode to the free spectral range can be modulated,particularly with neglectable influence by the size factor.Thus,the programmable region selective encoding process can be conducted simply by a printing program within several minutes.Besides,the encoded microfiber arrays are encapsulated into polydimethylsiloxane to reduce the scattering loss and environmental interference,and a printable encryption chip is realized.This work is expected to provide a platform for the printable encrypted devices. 展开更多
关键词 polymer microfiber whispering gallery mode microcavity laser polarization mode spacing optical encryption
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仿生纳米通道膜用于海洋渗透能转化研究进展 认领 引用
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作者 刘芳园 霍西学 +2 位作者 王俊茜 侯淑华 闻利平 《中国科学：化学》 CAS CSCD 北大核心 2025年第2期384-399,共16页
海洋渗透能因其无碳排放和环境友好的特点而备受关注.反向电渗析技术(RED)是实现海洋渗透能转化的有效方法,而膜作为RED的核心,其性能在这一过程中起着至关重要的作用,决定了海洋渗透能捕获效率.近年来,仿生纳米通道膜的研究取得了显著... 海洋渗透能因其无碳排放和环境友好的特点而备受关注.反向电渗析技术(RED)是实现海洋渗透能转化的有效方法,而膜作为RED的核心,其性能在这一过程中起着至关重要的作用,决定了海洋渗透能捕获效率.近年来,仿生纳米通道膜的研究取得了显著进展,这些膜模拟了生物体内离子通道的结构和功能,与传统离子交换膜相比,展示了优异的离子选择性和传导性能.本文系统综述了仿生纳米离子通道膜的制备技术及其在海洋渗透能转化中的应用现状与前景.同时,本文还总结了仿生纳米通道膜在实际应用中面临的主要挑战,并展望了其未来的发展方向. 展开更多
关键词 海洋渗透能 仿生纳米通道 离子选择性 离子输运
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