Predicting monsoon climate is one of the major endeavors in climate science and is becoming increasingly challenging due to global warming. The accuracy of monsoon seasonal predictions significantly impacts the lives ...Predicting monsoon climate is one of the major endeavors in climate science and is becoming increasingly challenging due to global warming. The accuracy of monsoon seasonal predictions significantly impacts the lives of billions who depend on or are affected by monsoons, as it is essential for the water cycle, food security, ecology, disaster prevention, and the economy of monsoon regions. Given the extensive literature on Asian monsoon climate prediction, we limit our focus to reviewing the seasonal prediction and predictability of the Asian Summer Monsoon (ASM). However, much of this review is also relevant to monsoon predictions in other seasons and regions. Over the past two decades, considerable progress has been made in the seasonal forecasting of the ASM, driven by an enhanced understanding of the sources of predictability and the dynamics of seasonal variability, along with advanced development in sophisticated models and technologies. This review centers on advances in understanding the physical foundation for monsoon climate prediction (section 2), significant findings and insights into the primary and regional sources of predictability arising from feedback processes among various climate components (sections 3 and 4), the effects of global warming and external forcings on predictability (section 5), developments in seasonal prediction models and techniques (section 6), the challenges and limitations of monsoon climate prediction (section 7), and emerging research trends with suggestions for future directions (section 8). We hope this review will stimulate creative activities to enhance monsoon climate prediction.展开更多
This study investigated the neuroprotective effects of lactate in subarachnoid hemorrhage,a severe cerebrovascular disease that is commonly caused by arterial aneurysm rupture and has limited early treatment options.L...This study investigated the neuroprotective effects of lactate in subarachnoid hemorrhage,a severe cerebrovascular disease that is commonly caused by arterial aneurysm rupture and has limited early treatment options.Lactate,a metabolic byproduct,has been shown to have neuroprotective properties,including enhancing cerebral microcirculation and reducing intracranial pressure in acute brain injury patients.However,the protective mechanisms of lactate in subarachnoid hemorrhage remain unknown.In this study,we showed that lactate alleviates early brain damage in subarachnoid hemorrhage by promoting neuronal lipid synthesis and the formation of lipid droplets in astrocytes.In vivo experiments using a subarachnoid hemorrhage mouse model showed that lactate treatment significantly improved neurological scores,reduced brain inflammation,and promoted lipid droplet formation in astrocytes within 24 hours.Lactate treatment increased free fatty acids levels in the brain.The results suggest that astrocytes absorbed these free fatty acids and converted them into lipid droplets,thus reducing cellular lipotoxicity.Moreover,lactate enhanced the antiapoptotic capacity of astrocytes by upregulating the expression of PLIN5,a protein crucial for lipid droplet formation.The inhibition of lipid synthesis or lipid droplet formation counteracted the neuroprotective effects of lactate,indicating that lactate’s protective role is closely linked to lipid metabolism and lipid droplet formation.In vitro experiments on HT22 neuronal cells exposed to hemin-an agent used to simulate subarachnoid hemorrhage injury-demonstrated that lactate mitigated cellular damage by reducing lipid peroxidation and preserving mitochondrial membrane potential.Lactate treatment in HT22 cells and astrocytes also showed that inhibition of lipid synthesis or lipid droplet formation reversed its protective effects,further emphasizing the importance of lipid metabolism in the neuroprotective action of lactate.This study provides insights into the neuroprotective mechanisms of lactate in subarachnoid hemorrhage.It indicates that lactate plays a role in promoting lipid synthesis in neurons and enhancing lipid droplet formation in astrocytes,thus mitigating brain damage and improving cell survival.These findings suggest that lactate,through its regulation of lipid metabolism,could be a potential therapeutic agent for subarachnoid hemorrhage.展开更多
In China,Xinjiang is a relatively independent epidemic region of wheat stripe rust,caused by Puccinia striiformis f.sp.tritici,due to great population genetic divergence of Xinjiang with other inland epidemic regions....In China,Xinjiang is a relatively independent epidemic region of wheat stripe rust,caused by Puccinia striiformis f.sp.tritici,due to great population genetic divergence of Xinjiang with other inland epidemic regions.In this region,race evolution was usually slower than inland populations.However,many new races have recently been found,and therefore,it is necessary for more understanding of the virulence evolution of the Xinjiang population.So,in this study,a 65 sexual progenies,derived from a Xinjiang single-urediospore isolate BGTB-1 of P.striiformis f.sp.tritici by selfing on alternate host barberry(Berberis aggregata).It was phenotyped on the 25 single Yr lines,and genotyped by 19 kompetitive allele-specific PCRsingle nucleotide polymorphism(KASP-SNP) markers.As a result,the 65 progenies were identified as 56 various virulence patterns(VPs),and neither of which was identical to the parental isolate,showed 100% virulence variation.Compared with the parental isolate,of all progenies,39(60.0%) had increased virulence,and 18(27.7%) had decreased virulence.All progenies exhibited avirulence to Yr10,Yr15,Yr32,and YrTr1 loci,and avirulence and virulence segregation at the remaining 21 Yr resistance loci.The results showed avirulence to Yr5,Yr7,and Yr76(A:V≈3:1) loci is controlled by a single dominant gene,and that to Yr6,Yr25,and Yr44(A:V≈1:3) loci by a single recessive gene.However,avirulence to the remaining 15 resistant loci including Yr1,Yr2,Yr3,Yr4,Yr8,Yr9,Yr17,Yr26(=Yr24),Yr28,Yr29,Yr43,YrSP,Yr27,YrA,and YrExp2,with various avirulence and virulence segregation ratios,is controlled by two genes with different gene effects,indicating complex genetic traits of the parental isolate.Totally,65 dissimilar genotypes detected among progenies using overall molecular markers,by which a linkage map was constructed,with a genetic distance of 441.0 cM.Interestingly,although the parental isolate was avirulent to Yr5,but 17 progenies showed virulence,showing the change of pathogenicity from avirulence to virulence at this resistance locus.It was for the first time to report that progenies with virulence to Yr5 produced sexually from avirulent parental isolate at this resistance locus.To our knowledge,this study offers an insight into inheritance,sexual reproduction and virulence variation of P.striiformis f.sp.tritici in Xinjiang,facilitating us to understand evolution of the rust pathogen in this region and accounting for Xinjiang population distinguished form other inland populations.Additionally,it is necessary to further confirm the roles of sexual reproduction in the emergence of new races and affecting population genetic diversity of P.striiformis f.sp.tritici under natural conditions in Xinjiang.展开更多
Impact statement.Protists are an underexplored but functionally important component of aerobic-activated granular sludge under pollution stress.Using metagenomics,we profiled protistan responses to ciprofloxacin,tricl...Impact statement.Protists are an underexplored but functionally important component of aerobic-activated granular sludge under pollution stress.Using metagenomics,we profiled protistan responses to ciprofloxacin,triclosan,and Cu2+(alone or in combination).展开更多
Microvascular anastomosis is a fundamental technique in microsurgery,and the development of suitable cuff tubes is crucial for improving the surgical efficiency and long-term vascular patency.Polyimide,a high-performa...Microvascular anastomosis is a fundamental technique in microsurgery,and the development of suitable cuff tubes is crucial for improving the surgical efficiency and long-term vascular patency.Polyimide,a high-performance polymer,offers excellent thermal stability,chemical resistance,and biocompatibility,making it a promising candidate for microvascular applications.In this study,we employed a dry-jet wetspinning method using P84 polyimide to fabricate polyimide(PI)cuff tubes.The effects of bore fluid flowrate,dope flowrate,and take-up speed on the structural morphology and mechanical properties of the tubes were systematically investigated.Heat treatment was applied to optimize the mechanical performance.Heat treatment above the glass transition temperature significantly enhances the solvent resistance and mechanical strength without altering the chemical structure.The PI cuff tubes demonstrated negligible cytotoxicity and hemolysis,no genotoxic or immunogenic effects,and no systemic organ toxicity.In vivo implantation showed sustained vascular patency and no local inflammatory response for up to 90 days post-operatively.The fabricated PI cuff tubes possessed high structural integrity,tunable flexibility,ideal mechanical properties,excellent biosafety,and outstanding in vivo performance,suggesting their strong potential for future clinical translation in microvascular anastomosis and vascular graft applications.展开更多
River fragmentation resulting from increasing reservoirs worldwide greatly disrupts natural hydrological processes and concomitant hydrogeochemical evolution,but the knowledge of river-groundwater interaction in this ...River fragmentation resulting from increasing reservoirs worldwide greatly disrupts natural hydrological processes and concomitant hydrogeochemical evolution,but the knowledge of river-groundwater interaction in this context is still poorly understood.To fill this gap,this study selects the Upper Zhanghe River,a headwater basin of the North China Plain,to identify the river-groundwater interplay and hydrochemical evolution impacted by three large reservoirs.A total of 107 water samples were collected during two sampling campaigns for chemical and stable isotopic analysis.Results showed that reservoirs interrupted the general pattern of isotopic enrichment along flow direction,and the heaviest isotopes were observed in three large reservoirs.Guanhe Reservoir’s downstream river water was jointly recharged by adjacent groundwater(∼76%)and reservoir water(∼24%).Houwan Reservoir and groundwater contributed to∼78%and∼22%of downstream river water.Zhangze Reservoir’s downstream groundwater was marginally recharged(∼17%)by the river water.Chemical signals showed that river water followed a progressive accumulation in salinity from upstream through reservoir to downstream.The evolution of river water types from upper reach(Ca-HCO3and Na-HCO3)to lower reach(Ca-Na-HCO3and Na-Ca-SO4-Cl)was closely related to reservoir water chemistry(Ca-Na-HCO3and Na-Ca-mixed anions).However,the riparian groundwater hydrochemical types(Ca-HCO3)were not significantly affected by three large reservoirs and river water.Groundwater chemical evolution was mainly controlled by dedolomitization,the evaporites’weathering,cation exchange,and anthropogenic pollutants.These findings contribute to future integrated management of multiple water sources in river basins worldwide regulated by large reservoirs.展开更多
This paper proposes a novel approach to address parameter uncertainties for state estimation in Markovian jump linear systems by leveraging transfer learning.Assume that the source domain model is available and reliab...This paper proposes a novel approach to address parameter uncertainties for state estimation in Markovian jump linear systems by leveraging transfer learning.Assume that the source domain model is available and reliable,and the target domain model has significant model parameter uncertainties.To enhance estimation performance in the target domain,the proposed method transfers model knowledge from the source domain and adjusts it using a tuning factor before incorporating it into the target domain estimator.More specifically,this approach involves transferring the modified probability density functions of state prediction from the source domain to the target domain and determining the tuning factor via structure variational Bayesian inference using measurements in the target domain.Using numerical examples and a 1-DOF torsion system,we showcase the competitiveness of the proposed state estimator compared to the existing robust state estimation methods when dealing with parameter uncertainties.The results highlight its capability to improve estimation accuracy in practical scenarios,showcasing its potential for real-world applications.展开更多
Excavation unloading damages rock masses,with preferential failure along geological defects in rock engineering,which may induce catastrophe geological hazards.It is important to study the failure of jointed rock unde...Excavation unloading damages rock masses,with preferential failure along geological defects in rock engineering,which may induce catastrophe geological hazards.It is important to study the failure of jointed rock under true-triaxial unloading conditions.3D DEM true-triaxial unloading modeling tests on rock with through-going joint considering the contributing factors,that is,the joint inclination,the initial confining pressure,and the unloading point,were conducted to study the rock mechanical properties,cracking behaviors,and failure characteristics.Six typical rock failure modes were summarized based on the development of main cracks,and the associated cracking mechanisms were studied by analysis of the ratio of tensile crack to shear crack.An energy criterion determining whether unloading-induced rock failure occurs instantaneously was proposed by comparing the accumulated elastic strain energy at the unloading point in true-triaxial unloading simulations with the limit elastic strain energy stored in rocks in biaxial compression modeling tests.Furthermore,the strength characteristics and applicability of the Mogi–Coulomb failure criterion in describing the failure of specimens with through-going joint under true-triaxial unloading conditions were studied.This study provides some new insights into true-triaxial unloading-induced failure of jointed rock,which may be valuable for revealing the mechanism of rock instabilities influenced by geological defects in deep excavations.展开更多
Alkaline water electrolysis holds great promise for environmental remediation and sustainable energy conversion,yet its efficiency is hampered by the sluggish kinetics of the hydrogen evolution reaction(HER).Ru-based ...Alkaline water electrolysis holds great promise for environmental remediation and sustainable energy conversion,yet its efficiency is hampered by the sluggish kinetics of the hydrogen evolution reaction(HER).Ru-based single-atom catalysts(SACs),with atomically dispersed active sites,offer enhanced catalytic performance.However,the development of Ru SACs is hindered by aggregation at high loadings and an obscured structure-activity relationship.In this work,we engineer Ru SACs supported on P,N self-doped carbon(PNC)derived from mushroom substrate residue through precise regulation of Ru content.This catalyst achieves stable Ru dispersion at loadings up to 2 wt%,thereby forming well-defined RuN3P1coordination structures.Density functional theory calculations reveal that the asymmetric Ru-N3P1 coordination modulates the electronic structure of Ru single atoms,facilitating both kinetically favorable water dissociation and thermodynamically balanced hydrogen adsorption,leading to superior HER activity.The optimized RuSAs/PNC-2wt%catalyst delivers exceptional alkaline HER performance,achieving an overpotential as low as 38 m V at 10 mA cm-2 and remarkable stability maintained over 325 h,attributed to its high density of accessible active sites and facilitated electron transfer kinetics.This study provides an effective strategy for constructing high-loading SACs and establishes a quantitative structure-activity relationship,guiding the design of advanced electrocatalysts for sustainable energy conversion.展开更多
Organophosphorus flame retardants(OPFRs)are used widely in industry and chemicals.As one of the representative OPFRs,tris-(2-chloroisopropyl)phosphate(TCIPP)has been detected in the atmospheric and water environment.T...Organophosphorus flame retardants(OPFRs)are used widely in industry and chemicals.As one of the representative OPFRs,tris-(2-chloroisopropyl)phosphate(TCIPP)has been detected in the atmospheric and water environment.To remove from environment and reduce the harm to ecosystem,the degradation of TCIPP in the atmosphere and water was investigated using quantum chemical methods.Result showed that in the presence of OH radicals the dominant channel of TCIPP is the H-abstraction with barriers less than 25 kJ/mol in the atmosphere and 34 kJ/mol in water.Subsequent reactions of the main degradation products with NO and O2were revealed to assess the environmental chemistry of TCIPP.At 298 K,the total reaction rate constant for TCIPP with OH radicals is 5.07×10–10cm3/(molecule・s)in atmosphere and 3.03×109(M・s)-1in water,respectively.Therefore,the atmospheric lifetime was estimated to be 0.55 h,and the half-life in wastewater with advanced oxidation processes was estimated to be 0.23–2.29 s.The H-abstraction channels for TCIPP degradation initiated by ClO radicals were studied,as well.The energy barriers are much higher than those with OH radicals,indicating that OH radicals show stronger oxidation capacity than ClO radicals to TCIPP.The ecotoxicity simulation for three aquatic organisms indicates that the acute and chronic toxicity of TCIPP decreases during degradation.Finally,substitutes were designed by introducing nitrogen atoms into TCIPP,and the reaction mechanism and toxicity of the new molecules were predicted to assess its environmental effect.展开更多
In complex media scattering,multiple scattering severely degrades the optical wavefront and results in blurred images,while the spectral distortion caused by the scattering effect leads to severe color distortion.Achi...In complex media scattering,multiple scattering severely degrades the optical wavefront and results in blurred images,while the spectral distortion caused by the scattering effect leads to severe color distortion.Achieving color high-resolution imaging through scattering media remains a significant challenge.Here,we propose a broadband,polarization-based method for color high-resolution imaging through scattering media.This approach enables high-resolution reconstruction by effectively separating the speckle illumination pattern from the mixed-scattering field information,leveraging polarization common-mode characteristics.Concurrently,it incorporates chromatic balance compensation to correct spectral aliasing in the scattered light field,enabling color high-resolution imaging through complex scattering media.To further optimize color distortion caused by scattering,a compensation strategy combining color constancy and white balance theory is adopted.Experimental results demonstrate that the proposed method significantly enhances both spatial resolution and color fidelity across various scattering conditions and target materials,showcasing strong adaptability and robustness.This approach provides an effective solution for achieving high-resolution color optical imaging in complex scattering environments.展开更多
With the development of onshore power grid projects in desert,Gobi and desertified regions as well as offshore wind power projects,electric energy requires longdistance transmission due to insufficient local consumpti...With the development of onshore power grid projects in desert,Gobi and desertified regions as well as offshore wind power projects,electric energy requires longdistance transmission due to insufficient local consumption.Modular multilevel converter based high-voltage direct current(MMC-HVDC)has become the mainstream transmission technology for large-scale remote wind farm integration.However,MMC-HVDC electrically decouples wind farms from the main grid,and its interaction with wind farms can trigger various oscillations.In addition,the MMC-HVDC connected wind farm system differs from single-converter grid-connected systems in structure,equipment complexity,and fault evolution,leading to problems such as low inertia,wideband oscillations and poor fault ride-through.To address these issues,coordinated control strategies considering dynamic interactions between wind farms and MMC-HVDC have been widely studied.This paper thus reviews such coordinated control strategies from three aspects:first,introducing common engineering symmetrical monopole/bipolar MMC-HVDC system structures;second,summarizing grid frequency sensing methods and inertia support control strategies for MMC-HVDC and wind farms;third,discussing coordinated oscillation suppression and fault ride-through control strategies,considering direct current(DC)-side faults,alternating current(AC)-side grid faults,and wind farm area faults.Finally,it summarizes deficiencies of existing studies for each challenge and prospects future research directions for MMC-HVDC connected wind farm systems.展开更多
Scene-level passive 3D imaging under natural conditions is highly challenging yet urgently demanded.Polarization 3D provides possibility but impeded by two major obstacles brought by natural large scenes:discontinuiti...Scene-level passive 3D imaging under natural conditions is highly challenging yet urgently demanded.Polarization 3D provides possibility but impeded by two major obstacles brought by natural large scenes:discontinuities of multiple targets and dynamic reconstruction.This study proposed a scene-level passive polarization 3D imaging method,integrating binocular stereo and polarization.We abstract the discontinuous targets reconstruction into a minimization problem.The pixel-level normal direction from polarization and the absolute scale information from binocular stereo vision then work as mutual constraints for iterative optimization of the problem.By iterating for final solution,the challenge of reconstructing discontinuous targets was tackled,and true depth was also recovered.The true depth then provides a reference for solving inter-frame scale inconsistencies which hinders dynamic reconstruction by the designed scale normalization strategy which globally aligns multi-view measurement data.Scene-level 3D structure was finally reconstructed through multi-frame point cloud fusion.We showcase wide-scene,high-accuracy passive video reconstructions on natural field scenes.Our passive polarization stereo represents a major advancement in scene-level 3D imaging and may find broad applications in fields requiring passive 3D imaging solutions.展开更多
The interrupted fatigue test method was utilized to investigate the damage evolution mechanism of the notch high-cycle fatigue(NHCF)in Ti-55531 alloy with a multilevel lamellar microstructure.The results reveal that s...The interrupted fatigue test method was utilized to investigate the damage evolution mechanism of the notch high-cycle fatigue(NHCF)in Ti-55531 alloy with a multilevel lamellar microstructure.The results reveal that significant microvoids and microcracks predominantly initiate at α/β interfaces under various notch root radii(R).Notably,even under larger R(0.75 mm),mutual interactions of stacking faults(SFs)−deformation twins,twins−twins,and SFs−SFs are observed.Furthermore,with decreasing R(0.34 and 0.14 mm),the volume fraction of SFs escalates significantly and twins are almost absent.Moreover,activated prismatic slip system decreases with a decrease in Schmidt factor and with the further decrease in R.Finally,strain localization near α/β interfaces contributes to the initiation of fatigue microcracks.展开更多
Chlorinated paraffins(CPs)are increasingly recognized for their environmental persistence and toxicological effects,yet their accumulation in seafood and the associated dietary health risks to humans and marine mammal...Chlorinated paraffins(CPs)are increasingly recognized for their environmental persistence and toxicological effects,yet their accumulation in seafood and the associated dietary health risks to humans and marine mammals remain poorly understood.Here,387 seafood samples representing 22 marine species were collected from the Lingdingyang(LDY)and west four regions(WFR)of the Pearl River Estuary,China,to quantify levels of shortand medium-chain chlorinated paraffins(SCCPs and MCCPs)and evaluate their dietary risks for both local human populations and marine mammals.Both SCCPs(335-2163 ng/g lipid weight)and MCCPs(792-4398 ng/g lipid weight)were detected in all samples,with significant spatial heterogeneity and interspecific differences observed.Spatially,CP concentrations were slightly higher in seafood from the LDY compared to the WFR,likely due to the LDY being closer to large industrial cluster.Higher CPs were generally accumulated by carnivores than by omnivores in both the LDY and WFR,suggesting that preying carnivores may have a more detrimental impact on dolphins due to the biomagnification potential of CPs demonstrated in our previous research.Dietary exposure risk analyses indicated that CP exposure through seafood consumption poses minimal health risk to local residents.In contrast,most prey species,with few exceptions,posed high CP-related dietary risks to humpback dolphins.The probability of the dolphins experiencing dietary exposure risk exceeds 93%in the LDY and 85%in the WFR.These findings underscore the need for ongoing monitoring of anthropogenic contaminants and their ecological consequences,particularly for vulnerable marine mammals.展开更多
Background Eating speed is a key eating behavior trait that influences energy intake and fat deposition,yet its regulation by host genetics and gut microbiota remains poorly understood in birds.Results We systematical...Background Eating speed is a key eating behavior trait that influences energy intake and fat deposition,yet its regulation by host genetics and gut microbiota remains poorly understood in birds.Results We systematically investigated the interplay among host genetics,gut microbiota,eating speed,and fat deposition in chickens.Phenotypic analyses revealed a positive association between eating speed and abdominal fat,and Mendelian randomization(MR)analysis identified a bidirectional feedback loop in which fat deposition promotes faster eating,which in turn exacerbates fat accumulation.Microbiome and MR analyses highlighted the ileal genus Bradyrhizobium as a causal regulator of both eating speed and fat deposition,with higher abundance reducing abdominal fat,triglyceride levels,and inflammatory markers.Microbiome genome-wide association studies(mGWAS)further identified host genetic variants and candidate genes,including convergent signals at RECK,influencing Bradyrhizobium abundance.Mediation analyses indicated that Bradyrhizobium modulates eating speed partially through its effects on abdominal fat,emphasizing a host-microbe-behavior feedback axis.Conclusions Our findings reveal a complex interplay among host genetics,gut microbes,and eating behavior,providing mechanistic insights and potential targets for precision interventions to optimize growth and metabolic health in poultry.展开更多
OVATE family proteins(OFPs) are key regulators involved in plant development and stress responses.However, their biological roles in soybean remain largely unclear. In this study, we identified GmOFP8,a member of OVAT...OVATE family proteins(OFPs) are key regulators involved in plant development and stress responses.However, their biological roles in soybean remain largely unclear. In this study, we identified GmOFP8,a member of OVATE family in soybean, which exhibits root-specific expression and is transcriptionally responsive to both brassinolide and drought stress. Overexpression of GmOFP8 increased drought tolerance and nodule numbers, whereas knockout of GmOFP8 resulted in reduced drought resistance and fewer nodules, indicating its positive role in regulating drought stress responses and nodulation.Protein-protein interaction analyses demonstrated that GmOFP8 physically interacted with the glycogen synthase kinase 3-like kinase, GmSK2, and this interaction promotes the nucleocytoplasmic shuttling of GmOFP8. Furthermore, overexpression of GmSK2 in soybean hairy roots suppressed both drought tolerance and nodulation. Based on these findings, we propose that GmSK2 plays a conserved role in mediating the phosphorylation status of GmOFP8, as observed in rice, thereby contributing to the regulation of drought tolerance and nodulation in soybean. These results provide valuable genetic resources for molecular breeding strategies aimed at improving stress resilience and nitrogen fixation capacity in soybean.展开更多
Microrobotic systems are emerging as transformative technology for minimally invasive medicine,driven by innovations in actuation mechanisms,advanced fabrication paradigms,and multifunctional system integration.This c...Microrobotic systems are emerging as transformative technology for minimally invasive medicine,driven by innovations in actuation mechanisms,advanced fabrication paradigms,and multifunctional system integration.This comprehensive review analyzes the evolution of microrobotic technologies through three critical dimensions:(1)actuation modalities,including magnetic,optical,acoustic,chemical,and biological actuation,with a focus on the synergistic advantages of hybrid actuation strategies in complex internal physiological environments;(2)Fabrication methods cover technolo-gies such as photolithography,microinjection molding,self-assembly,and 3D printing,emphasizing innovative strategies involving multi-technology integration and collaborative manufacturing of bioon-bio hybrid materials;(3)Internal phys-iological applications involve disease diagnosis,targeted drug delivery,minimally invasive surgery,tissue engineering,and cell manipulation,highlighting the broad prospects of microrobots in precision medicine.Despite remarkable progress,critical challenges remain,including low actuation efficiency,as seen in acoustic systems,limited biocompatibility,exem-plified by the toxicity of hydrogen peroxide in chemical actuation,delayed clinical translation,and other related challenges that must be addressed to advance the field.展开更多
Background:According to the 2022 update of the BCLC strategy,laparoscopic liver resection(LLR)is considered feasible for BCLC stage 0-A hepatocellular carcinoma(HCC)patients with clinically significant portal hyperten...Background:According to the 2022 update of the BCLC strategy,laparoscopic liver resection(LLR)is considered feasible for BCLC stage 0-A hepatocellular carcinoma(HCC)patients with clinically significant portal hypertension(CSPH).However,there is still no research to explore the outcomes of laparoscopic versus open liver resection(OLR)in the specific patients with BCLC stage 0-A HCC and CSPH.Methods:Patients diagnosed with BCLC stage 0-A HCC and CSPH who underwent liver resection at West China Hospital of Sichuan University from February 2018 to December 2022 were analyzed.Demographic characteristics,pathological findings and postoperative outcomes were compared using propensity score matching(PSM).Long-term outcomes after surgery were analyzed using Kaplan-Meier analysis both before and after PSM.Results:A total of 409 patients,including 261 LLRs and 148 OLRs,were enrolled in this study.There were imbalances between the groups in baseline information.After 1:1 PSM,118 patients were included in each group with comparable baseline characteristics.Patients in the LLR group had significantly less intraoperative blood loss compared to those in the OLR group(median 223 vs.318 mL,P75×109/L.Conclusions:Compared with OLR,LLR had less intraoperative blood loss,fewer postoperative complications and comparable oncological outcomes for patients with BCLC stage 0/A HCC and CSPH.展开更多
The chemical reduction of pollutants by Fe2+aq-iron oxides heterogeneous systems is an important component of abiotic natural attenuation.A linear free energy relationship(LFERs)can be established between the re...The chemical reduction of pollutants by Fe2+aq-iron oxides heterogeneous systems is an important component of abiotic natural attenuation.A linear free energy relationship(LFERs)can be established between the reduction potential(EH)of the heterogeneous system and the kinetic parameter(k)of pollutant degradation.However,this relationship was limited to a single iron oxide.The difference in iron oxides particle size and the coexisting anions and cations in groundwater should also be considered.Here,this study investigated the effect of coexisting ions on the nitrobenzene reduction in the Fe2+aq-goethite systems with different particle sizes,and explored the response of LFERs.The results indicated that the standard reduction potential(EHO)of Gt-200 was highest among Gt-200,Gt-700 and Gt-1000.However,the nitrobenzene reduction rate exhibited the highest in the Fe2+aq-Gt-200 heterogenous systems,which was ascribed to the best adsorption affinity of Fe2+aqon Gt-200.Besides,the presence of cations and anions inhibited the reduction rate of nitrobenzene.As for LFERs,the slopes were the same for the Fe2+aq-goethite systems with different particle sizes and coexisting ions.The intercept terms were different.The maximum difference in intercept terms was reduced from 0.98 to 0.37 by correcting the LFERs based on the saturated adsorption capacity of Fe2+aq.The adsorption performance of Fe2+aqon goethite was an important factor affecting the reduction of nitrobenzene.These findings would provide theoretical support for accurately predicting the abiotic natural attenuation rate of nitrobenzene in the presence of coexisting ions in actual groundwater.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.U2342208)support from NSF/Climate Dynamics Award#2025057。
摘要Predicting monsoon climate is one of the major endeavors in climate science and is becoming increasingly challenging due to global warming. The accuracy of monsoon seasonal predictions significantly impacts the lives of billions who depend on or are affected by monsoons, as it is essential for the water cycle, food security, ecology, disaster prevention, and the economy of monsoon regions. Given the extensive literature on Asian monsoon climate prediction, we limit our focus to reviewing the seasonal prediction and predictability of the Asian Summer Monsoon (ASM). However, much of this review is also relevant to monsoon predictions in other seasons and regions. Over the past two decades, considerable progress has been made in the seasonal forecasting of the ASM, driven by an enhanced understanding of the sources of predictability and the dynamics of seasonal variability, along with advanced development in sophisticated models and technologies. This review centers on advances in understanding the physical foundation for monsoon climate prediction (section 2), significant findings and insights into the primary and regional sources of predictability arising from feedback processes among various climate components (sections 3 and 4), the effects of global warming and external forcings on predictability (section 5), developments in seasonal prediction models and techniques (section 6), the challenges and limitations of monsoon climate prediction (section 7), and emerging research trends with suggestions for future directions (section 8). We hope this review will stimulate creative activities to enhance monsoon climate prediction.
基金National Nature Science Foundation of China,No.81870944(to FL).
摘要This study investigated the neuroprotective effects of lactate in subarachnoid hemorrhage,a severe cerebrovascular disease that is commonly caused by arterial aneurysm rupture and has limited early treatment options.Lactate,a metabolic byproduct,has been shown to have neuroprotective properties,including enhancing cerebral microcirculation and reducing intracranial pressure in acute brain injury patients.However,the protective mechanisms of lactate in subarachnoid hemorrhage remain unknown.In this study,we showed that lactate alleviates early brain damage in subarachnoid hemorrhage by promoting neuronal lipid synthesis and the formation of lipid droplets in astrocytes.In vivo experiments using a subarachnoid hemorrhage mouse model showed that lactate treatment significantly improved neurological scores,reduced brain inflammation,and promoted lipid droplet formation in astrocytes within 24 hours.Lactate treatment increased free fatty acids levels in the brain.The results suggest that astrocytes absorbed these free fatty acids and converted them into lipid droplets,thus reducing cellular lipotoxicity.Moreover,lactate enhanced the antiapoptotic capacity of astrocytes by upregulating the expression of PLIN5,a protein crucial for lipid droplet formation.The inhibition of lipid synthesis or lipid droplet formation counteracted the neuroprotective effects of lactate,indicating that lactate’s protective role is closely linked to lipid metabolism and lipid droplet formation.In vitro experiments on HT22 neuronal cells exposed to hemin-an agent used to simulate subarachnoid hemorrhage injury-demonstrated that lactate mitigated cellular damage by reducing lipid peroxidation and preserving mitochondrial membrane potential.Lactate treatment in HT22 cells and astrocytes also showed that inhibition of lipid synthesis or lipid droplet formation reversed its protective effects,further emphasizing the importance of lipid metabolism in the neuroprotective action of lactate.This study provides insights into the neuroprotective mechanisms of lactate in subarachnoid hemorrhage.It indicates that lactate plays a role in promoting lipid synthesis in neurons and enhancing lipid droplet formation in astrocytes,thus mitigating brain damage and improving cell survival.These findings suggest that lactate,through its regulation of lipid metabolism,could be a potential therapeutic agent for subarachnoid hemorrhage.
基金financially supported by Xinjiang Major Science and Technology Projects,China (2023A02009)。
摘要In China,Xinjiang is a relatively independent epidemic region of wheat stripe rust,caused by Puccinia striiformis f.sp.tritici,due to great population genetic divergence of Xinjiang with other inland epidemic regions.In this region,race evolution was usually slower than inland populations.However,many new races have recently been found,and therefore,it is necessary for more understanding of the virulence evolution of the Xinjiang population.So,in this study,a 65 sexual progenies,derived from a Xinjiang single-urediospore isolate BGTB-1 of P.striiformis f.sp.tritici by selfing on alternate host barberry(Berberis aggregata).It was phenotyped on the 25 single Yr lines,and genotyped by 19 kompetitive allele-specific PCRsingle nucleotide polymorphism(KASP-SNP) markers.As a result,the 65 progenies were identified as 56 various virulence patterns(VPs),and neither of which was identical to the parental isolate,showed 100% virulence variation.Compared with the parental isolate,of all progenies,39(60.0%) had increased virulence,and 18(27.7%) had decreased virulence.All progenies exhibited avirulence to Yr10,Yr15,Yr32,and YrTr1 loci,and avirulence and virulence segregation at the remaining 21 Yr resistance loci.The results showed avirulence to Yr5,Yr7,and Yr76(A:V≈3:1) loci is controlled by a single dominant gene,and that to Yr6,Yr25,and Yr44(A:V≈1:3) loci by a single recessive gene.However,avirulence to the remaining 15 resistant loci including Yr1,Yr2,Yr3,Yr4,Yr8,Yr9,Yr17,Yr26(=Yr24),Yr28,Yr29,Yr43,YrSP,Yr27,YrA,and YrExp2,with various avirulence and virulence segregation ratios,is controlled by two genes with different gene effects,indicating complex genetic traits of the parental isolate.Totally,65 dissimilar genotypes detected among progenies using overall molecular markers,by which a linkage map was constructed,with a genetic distance of 441.0 cM.Interestingly,although the parental isolate was avirulent to Yr5,but 17 progenies showed virulence,showing the change of pathogenicity from avirulence to virulence at this resistance locus.It was for the first time to report that progenies with virulence to Yr5 produced sexually from avirulent parental isolate at this resistance locus.To our knowledge,this study offers an insight into inheritance,sexual reproduction and virulence variation of P.striiformis f.sp.tritici in Xinjiang,facilitating us to understand evolution of the rust pathogen in this region and accounting for Xinjiang population distinguished form other inland populations.Additionally,it is necessary to further confirm the roles of sexual reproduction in the emergence of new races and affecting population genetic diversity of P.striiformis f.sp.tritici under natural conditions in Xinjiang.
基金supported by the National Natural Science Foundation of China(Nos.42277382 and 42030703)the Natural Science Foundation of Guangdong Province,China(No.2023A1515011526)+2 种基金the Guangdong Natural Science Funds for Distinguished Young Scholar(No.2023B1515020096)the Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)(Nos.SML2024SP022 and SML2024SP002)the China Postdoctoral Science Foundation(No.2025M771252).
摘要Impact statement.Protists are an underexplored but functionally important component of aerobic-activated granular sludge under pollution stress.Using metagenomics,we profiled protistan responses to ciprofloxacin,triclosan,and Cu2+(alone or in combination).
基金supported by the Science and Technology Commission of Shanghai Municipality(No.22S31904500)the National Natural Science Foundation of China(No.82102354)the Fundamental Research Funds for the Central Universities(Nos.2232025A-02 and CUSF-DH-D-2025006)。
摘要Microvascular anastomosis is a fundamental technique in microsurgery,and the development of suitable cuff tubes is crucial for improving the surgical efficiency and long-term vascular patency.Polyimide,a high-performance polymer,offers excellent thermal stability,chemical resistance,and biocompatibility,making it a promising candidate for microvascular applications.In this study,we employed a dry-jet wetspinning method using P84 polyimide to fabricate polyimide(PI)cuff tubes.The effects of bore fluid flowrate,dope flowrate,and take-up speed on the structural morphology and mechanical properties of the tubes were systematically investigated.Heat treatment was applied to optimize the mechanical performance.Heat treatment above the glass transition temperature significantly enhances the solvent resistance and mechanical strength without altering the chemical structure.The PI cuff tubes demonstrated negligible cytotoxicity and hemolysis,no genotoxic or immunogenic effects,and no systemic organ toxicity.In vivo implantation showed sustained vascular patency and no local inflammatory response for up to 90 days post-operatively.The fabricated PI cuff tubes possessed high structural integrity,tunable flexibility,ideal mechanical properties,excellent biosafety,and outstanding in vivo performance,suggesting their strong potential for future clinical translation in microvascular anastomosis and vascular graft applications.
基金supported by the National Natural Science Foundation of China (No. 42471039)the Natural Science Foundation of Hebei Province (No. D2022402013)the Science Research Project of Hebei Education Department (No. BJ2021014)
摘要River fragmentation resulting from increasing reservoirs worldwide greatly disrupts natural hydrological processes and concomitant hydrogeochemical evolution,but the knowledge of river-groundwater interaction in this context is still poorly understood.To fill this gap,this study selects the Upper Zhanghe River,a headwater basin of the North China Plain,to identify the river-groundwater interplay and hydrochemical evolution impacted by three large reservoirs.A total of 107 water samples were collected during two sampling campaigns for chemical and stable isotopic analysis.Results showed that reservoirs interrupted the general pattern of isotopic enrichment along flow direction,and the heaviest isotopes were observed in three large reservoirs.Guanhe Reservoir’s downstream river water was jointly recharged by adjacent groundwater(∼76%)and reservoir water(∼24%).Houwan Reservoir and groundwater contributed to∼78%and∼22%of downstream river water.Zhangze Reservoir’s downstream groundwater was marginally recharged(∼17%)by the river water.Chemical signals showed that river water followed a progressive accumulation in salinity from upstream through reservoir to downstream.The evolution of river water types from upper reach(Ca-HCO3and Na-HCO3)to lower reach(Ca-Na-HCO3and Na-Ca-SO4-Cl)was closely related to reservoir water chemistry(Ca-Na-HCO3and Na-Ca-mixed anions).However,the riparian groundwater hydrochemical types(Ca-HCO3)were not significantly affected by three large reservoirs and river water.Groundwater chemical evolution was mainly controlled by dedolomitization,the evaporites’weathering,cation exchange,and anthropogenic pollutants.These findings contribute to future integrated management of multiple water sources in river basins worldwide regulated by large reservoirs.
基金supported by the National Natural Science Foundation of China(62503201)the Basic Research Program of Jiangsu(BK20251595)+2 种基金the China Postdoctoral Science Foundation(2025M771693)the Postdoctoral Fellowship Program of the China Postdoctoral Science Foundation(GZC20251168)the Fundamental Research Funds for the Central Universities(JUSRP202501067)。
摘要This paper proposes a novel approach to address parameter uncertainties for state estimation in Markovian jump linear systems by leveraging transfer learning.Assume that the source domain model is available and reliable,and the target domain model has significant model parameter uncertainties.To enhance estimation performance in the target domain,the proposed method transfers model knowledge from the source domain and adjusts it using a tuning factor before incorporating it into the target domain estimator.More specifically,this approach involves transferring the modified probability density functions of state prediction from the source domain to the target domain and determining the tuning factor via structure variational Bayesian inference using measurements in the target domain.Using numerical examples and a 1-DOF torsion system,we showcase the competitiveness of the proposed state estimator compared to the existing robust state estimation methods when dealing with parameter uncertainties.The results highlight its capability to improve estimation accuracy in practical scenarios,showcasing its potential for real-world applications.
基金Shandong Provincial Natural Science Foundation,Grant/Award Number:ZR2022QD102Demonstration Project of Benefiting People with Science and Technology of Qingdao,China,Grant/Award Number:23-2-8-cspz-13-nsh。
摘要Excavation unloading damages rock masses,with preferential failure along geological defects in rock engineering,which may induce catastrophe geological hazards.It is important to study the failure of jointed rock under true-triaxial unloading conditions.3D DEM true-triaxial unloading modeling tests on rock with through-going joint considering the contributing factors,that is,the joint inclination,the initial confining pressure,and the unloading point,were conducted to study the rock mechanical properties,cracking behaviors,and failure characteristics.Six typical rock failure modes were summarized based on the development of main cracks,and the associated cracking mechanisms were studied by analysis of the ratio of tensile crack to shear crack.An energy criterion determining whether unloading-induced rock failure occurs instantaneously was proposed by comparing the accumulated elastic strain energy at the unloading point in true-triaxial unloading simulations with the limit elastic strain energy stored in rocks in biaxial compression modeling tests.Furthermore,the strength characteristics and applicability of the Mogi–Coulomb failure criterion in describing the failure of specimens with through-going joint under true-triaxial unloading conditions were studied.This study provides some new insights into true-triaxial unloading-induced failure of jointed rock,which may be valuable for revealing the mechanism of rock instabilities influenced by geological defects in deep excavations.
基金supported by the Guizhou Provincial Science and Technology Projects(NO.ZKZD2023004)the National Natural Science Foundation of China(NO.22568017)+3 种基金the Key Laboratory of Carbon-based Energy Molecular Chemical Utilization Technology in Guizhou Province(NO.2023008)the Guizhou Science and Technology Platform Foundation(NO.ZSYS 2025-033)the One Hundred Person Project of Guizhou Province(NO.GCC 2023013)the Scientific and Technological Innovation Talents Team Project of Guizhou Province(NO.CXTD2023029)。
摘要Alkaline water electrolysis holds great promise for environmental remediation and sustainable energy conversion,yet its efficiency is hampered by the sluggish kinetics of the hydrogen evolution reaction(HER).Ru-based single-atom catalysts(SACs),with atomically dispersed active sites,offer enhanced catalytic performance.However,the development of Ru SACs is hindered by aggregation at high loadings and an obscured structure-activity relationship.In this work,we engineer Ru SACs supported on P,N self-doped carbon(PNC)derived from mushroom substrate residue through precise regulation of Ru content.This catalyst achieves stable Ru dispersion at loadings up to 2 wt%,thereby forming well-defined RuN3P1coordination structures.Density functional theory calculations reveal that the asymmetric Ru-N3P1 coordination modulates the electronic structure of Ru single atoms,facilitating both kinetically favorable water dissociation and thermodynamically balanced hydrogen adsorption,leading to superior HER activity.The optimized RuSAs/PNC-2wt%catalyst delivers exceptional alkaline HER performance,achieving an overpotential as low as 38 m V at 10 mA cm-2 and remarkable stability maintained over 325 h,attributed to its high density of accessible active sites and facilitated electron transfer kinetics.This study provides an effective strategy for constructing high-loading SACs and establishes a quantitative structure-activity relationship,guiding the design of advanced electrocatalysts for sustainable energy conversion.
基金supported by the Natural Science Foundation of Shandong Province(No.ZR2024MB073)the Natural Science Foundation of Jilin Province(No.20220101076JC).
摘要Organophosphorus flame retardants(OPFRs)are used widely in industry and chemicals.As one of the representative OPFRs,tris-(2-chloroisopropyl)phosphate(TCIPP)has been detected in the atmospheric and water environment.To remove from environment and reduce the harm to ecosystem,the degradation of TCIPP in the atmosphere and water was investigated using quantum chemical methods.Result showed that in the presence of OH radicals the dominant channel of TCIPP is the H-abstraction with barriers less than 25 kJ/mol in the atmosphere and 34 kJ/mol in water.Subsequent reactions of the main degradation products with NO and O2were revealed to assess the environmental chemistry of TCIPP.At 298 K,the total reaction rate constant for TCIPP with OH radicals is 5.07×10–10cm3/(molecule・s)in atmosphere and 3.03×109(M・s)-1in water,respectively.Therefore,the atmospheric lifetime was estimated to be 0.55 h,and the half-life in wastewater with advanced oxidation processes was estimated to be 0.23–2.29 s.The H-abstraction channels for TCIPP degradation initiated by ClO radicals were studied,as well.The energy barriers are much higher than those with OH radicals,indicating that OH radicals show stronger oxidation capacity than ClO radicals to TCIPP.The ecotoxicity simulation for three aquatic organisms indicates that the acute and chronic toxicity of TCIPP decreases during degradation.Finally,substitutes were designed by introducing nitrogen atoms into TCIPP,and the reaction mechanism and toxicity of the new molecules were predicted to assess its environmental effect.
基金supported by the National Natural Science Foundation of China (Grant Nos. 62405231, 62405235, and 62575229)the National Key Laboratory of Space Target Awareness (Grant Nos. STA2024KGL0203, STA2024ZCA0203, and STA-24-04-05)+3 种基金the Beijing Key Laboratory of Advanced Optical Remote Sensing Technology (Grant No. AORS202405)the China Postdoctoral Science Foundation (Grant No. 2024M762527)the Shaanxi Province High-level Innovation and Entrepreneurship Talent Program (Grant No. H02439005)the Natural Science Foundation of Shaanxi (Grant Nos. S2024-JC-JCQN-60, S2025-JCQYTS-0107, and 2025JC-QYCX-05)。
摘要In complex media scattering,multiple scattering severely degrades the optical wavefront and results in blurred images,while the spectral distortion caused by the scattering effect leads to severe color distortion.Achieving color high-resolution imaging through scattering media remains a significant challenge.Here,we propose a broadband,polarization-based method for color high-resolution imaging through scattering media.This approach enables high-resolution reconstruction by effectively separating the speckle illumination pattern from the mixed-scattering field information,leveraging polarization common-mode characteristics.Concurrently,it incorporates chromatic balance compensation to correct spectral aliasing in the scattered light field,enabling color high-resolution imaging through complex scattering media.To further optimize color distortion caused by scattering,a compensation strategy combining color constancy and white balance theory is adopted.Experimental results demonstrate that the proposed method significantly enhances both spatial resolution and color fidelity across various scattering conditions and target materials,showcasing strong adaptability and robustness.This approach provides an effective solution for achieving high-resolution color optical imaging in complex scattering environments.
基金supported by Smart Grid-National Science and Technology Major Project(Novel Grid-Integrated Transmission System for Far-Offshore Wind Power,No.2024ZD0801300)。
摘要With the development of onshore power grid projects in desert,Gobi and desertified regions as well as offshore wind power projects,electric energy requires longdistance transmission due to insufficient local consumption.Modular multilevel converter based high-voltage direct current(MMC-HVDC)has become the mainstream transmission technology for large-scale remote wind farm integration.However,MMC-HVDC electrically decouples wind farms from the main grid,and its interaction with wind farms can trigger various oscillations.In addition,the MMC-HVDC connected wind farm system differs from single-converter grid-connected systems in structure,equipment complexity,and fault evolution,leading to problems such as low inertia,wideband oscillations and poor fault ride-through.To address these issues,coordinated control strategies considering dynamic interactions between wind farms and MMC-HVDC have been widely studied.This paper thus reviews such coordinated control strategies from three aspects:first,introducing common engineering symmetrical monopole/bipolar MMC-HVDC system structures;second,summarizing grid frequency sensing methods and inertia support control strategies for MMC-HVDC and wind farms;third,discussing coordinated oscillation suppression and fault ride-through control strategies,considering direct current(DC)-side faults,alternating current(AC)-side grid faults,and wind farm area faults.Finally,it summarizes deficiencies of existing studies for each challenge and prospects future research directions for MMC-HVDC connected wind farm systems.
基金funded by the National Natural Science Foundation of China(62375212,62405231,62405235).
摘要Scene-level passive 3D imaging under natural conditions is highly challenging yet urgently demanded.Polarization 3D provides possibility but impeded by two major obstacles brought by natural large scenes:discontinuities of multiple targets and dynamic reconstruction.This study proposed a scene-level passive polarization 3D imaging method,integrating binocular stereo and polarization.We abstract the discontinuous targets reconstruction into a minimization problem.The pixel-level normal direction from polarization and the absolute scale information from binocular stereo vision then work as mutual constraints for iterative optimization of the problem.By iterating for final solution,the challenge of reconstructing discontinuous targets was tackled,and true depth was also recovered.The true depth then provides a reference for solving inter-frame scale inconsistencies which hinders dynamic reconstruction by the designed scale normalization strategy which globally aligns multi-view measurement data.Scene-level 3D structure was finally reconstructed through multi-frame point cloud fusion.We showcase wide-scene,high-accuracy passive video reconstructions on natural field scenes.Our passive polarization stereo represents a major advancement in scene-level 3D imaging and may find broad applications in fields requiring passive 3D imaging solutions.
基金supported by the National Natural Science Foundation of China(Nos.52061005,52261025)the Science and Technology Programs of Guizhou Province,China(Nos.YQK[2023]009,CXTD[2023]009)the Technology Innovation Leading Program of Shaanxi Province,China(No.2024ZCYYDP92)。
摘要The interrupted fatigue test method was utilized to investigate the damage evolution mechanism of the notch high-cycle fatigue(NHCF)in Ti-55531 alloy with a multilevel lamellar microstructure.The results reveal that significant microvoids and microcracks predominantly initiate at α/β interfaces under various notch root radii(R).Notably,even under larger R(0.75 mm),mutual interactions of stacking faults(SFs)−deformation twins,twins−twins,and SFs−SFs are observed.Furthermore,with decreasing R(0.34 and 0.14 mm),the volume fraction of SFs escalates significantly and twins are almost absent.Moreover,activated prismatic slip system decreases with a decrease in Schmidt factor and with the further decrease in R.Finally,strain localization near α/β interfaces contributes to the initiation of fatigue microcracks.
基金supported by Southern Marine Science and Engineering GuangdongLaboratory(Zhuhai)(Nos.SML2024SP024 and SML2023SP220)the National Key Research and Development Program of China(No.2022YFF1301603)+3 种基金the National Natural Science Foundation of China(No.42476126)the Natural Science Foundation of Guangdong Province in China(No.2023A1515012415)the Innovation Group Project of Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)(No.311024004)the Fundamental Research Funds for the Central Universities,Sun Yat-sen University(Nos.24qnpy325 and 24qnpy328)。
摘要Chlorinated paraffins(CPs)are increasingly recognized for their environmental persistence and toxicological effects,yet their accumulation in seafood and the associated dietary health risks to humans and marine mammals remain poorly understood.Here,387 seafood samples representing 22 marine species were collected from the Lingdingyang(LDY)and west four regions(WFR)of the Pearl River Estuary,China,to quantify levels of shortand medium-chain chlorinated paraffins(SCCPs and MCCPs)and evaluate their dietary risks for both local human populations and marine mammals.Both SCCPs(335-2163 ng/g lipid weight)and MCCPs(792-4398 ng/g lipid weight)were detected in all samples,with significant spatial heterogeneity and interspecific differences observed.Spatially,CP concentrations were slightly higher in seafood from the LDY compared to the WFR,likely due to the LDY being closer to large industrial cluster.Higher CPs were generally accumulated by carnivores than by omnivores in both the LDY and WFR,suggesting that preying carnivores may have a more detrimental impact on dolphins due to the biomagnification potential of CPs demonstrated in our previous research.Dietary exposure risk analyses indicated that CP exposure through seafood consumption poses minimal health risk to local residents.In contrast,most prey species,with few exceptions,posed high CP-related dietary risks to humpback dolphins.The probability of the dolphins experiencing dietary exposure risk exceeds 93%in the LDY and 85%in the WFR.These findings underscore the need for ongoing monitoring of anthropogenic contaminants and their ecological consequences,particularly for vulnerable marine mammals.
基金supported by Chinese Universities Scientific Fund(2025TC121)Hainan Provincial Natural Science Foundation of China(325RC806)the China Agricultural University Sanya Research Institute"Young Research Fellow"Start-up Funding Project(SYND-QDJF-04)。
摘要Background Eating speed is a key eating behavior trait that influences energy intake and fat deposition,yet its regulation by host genetics and gut microbiota remains poorly understood in birds.Results We systematically investigated the interplay among host genetics,gut microbiota,eating speed,and fat deposition in chickens.Phenotypic analyses revealed a positive association between eating speed and abdominal fat,and Mendelian randomization(MR)analysis identified a bidirectional feedback loop in which fat deposition promotes faster eating,which in turn exacerbates fat accumulation.Microbiome and MR analyses highlighted the ileal genus Bradyrhizobium as a causal regulator of both eating speed and fat deposition,with higher abundance reducing abdominal fat,triglyceride levels,and inflammatory markers.Microbiome genome-wide association studies(mGWAS)further identified host genetic variants and candidate genes,including convergent signals at RECK,influencing Bradyrhizobium abundance.Mediation analyses indicated that Bradyrhizobium modulates eating speed partially through its effects on abdominal fat,emphasizing a host-microbe-behavior feedback axis.Conclusions Our findings reveal a complex interplay among host genetics,gut microbes,and eating behavior,providing mechanistic insights and potential targets for precision interventions to optimize growth and metabolic health in poultry.
基金supported by the Chongqing Technology Innovation and Application Development Special Key Project (cstb2023tiad—kpx0038)Municipal Fiscal scientific research project of Chongqing Academy of Agricultural Sciences (cqaas2023sjczhx007)+1 种基金Collection, Utilization and Innovation of Germplasm Resources by Research Institutes and Enterprises of Chongqing (cqnyncw-kqlhtxm)Special Project on Performance Incentive Guidance of Chongqing Scientific Research Institution (cstb2024jxjl-yfx0002)。
摘要OVATE family proteins(OFPs) are key regulators involved in plant development and stress responses.However, their biological roles in soybean remain largely unclear. In this study, we identified GmOFP8,a member of OVATE family in soybean, which exhibits root-specific expression and is transcriptionally responsive to both brassinolide and drought stress. Overexpression of GmOFP8 increased drought tolerance and nodule numbers, whereas knockout of GmOFP8 resulted in reduced drought resistance and fewer nodules, indicating its positive role in regulating drought stress responses and nodulation.Protein-protein interaction analyses demonstrated that GmOFP8 physically interacted with the glycogen synthase kinase 3-like kinase, GmSK2, and this interaction promotes the nucleocytoplasmic shuttling of GmOFP8. Furthermore, overexpression of GmSK2 in soybean hairy roots suppressed both drought tolerance and nodulation. Based on these findings, we propose that GmSK2 plays a conserved role in mediating the phosphorylation status of GmOFP8, as observed in rice, thereby contributing to the regulation of drought tolerance and nodulation in soybean. These results provide valuable genetic resources for molecular breeding strategies aimed at improving stress resilience and nitrogen fixation capacity in soybean.
基金National Natural Science Foundation of China(Grant No.61903157)the Foundation of State Key Laboratory of Robotics(Grand No.2024-O08).
摘要Microrobotic systems are emerging as transformative technology for minimally invasive medicine,driven by innovations in actuation mechanisms,advanced fabrication paradigms,and multifunctional system integration.This comprehensive review analyzes the evolution of microrobotic technologies through three critical dimensions:(1)actuation modalities,including magnetic,optical,acoustic,chemical,and biological actuation,with a focus on the synergistic advantages of hybrid actuation strategies in complex internal physiological environments;(2)Fabrication methods cover technolo-gies such as photolithography,microinjection molding,self-assembly,and 3D printing,emphasizing innovative strategies involving multi-technology integration and collaborative manufacturing of bioon-bio hybrid materials;(3)Internal phys-iological applications involve disease diagnosis,targeted drug delivery,minimally invasive surgery,tissue engineering,and cell manipulation,highlighting the broad prospects of microrobots in precision medicine.Despite remarkable progress,critical challenges remain,including low actuation efficiency,as seen in acoustic systems,limited biocompatibility,exem-plified by the toxicity of hydrogen peroxide in chemical actuation,delayed clinical translation,and other related challenges that must be addressed to advance the field.
基金supported by grants from the Sichuan Science and Technology Program(2023YFQ0094)the 1.3.5 project for disciplines of excellence,West China Hospital,Sichuan University(25HXJS028).
摘要Background:According to the 2022 update of the BCLC strategy,laparoscopic liver resection(LLR)is considered feasible for BCLC stage 0-A hepatocellular carcinoma(HCC)patients with clinically significant portal hypertension(CSPH).However,there is still no research to explore the outcomes of laparoscopic versus open liver resection(OLR)in the specific patients with BCLC stage 0-A HCC and CSPH.Methods:Patients diagnosed with BCLC stage 0-A HCC and CSPH who underwent liver resection at West China Hospital of Sichuan University from February 2018 to December 2022 were analyzed.Demographic characteristics,pathological findings and postoperative outcomes were compared using propensity score matching(PSM).Long-term outcomes after surgery were analyzed using Kaplan-Meier analysis both before and after PSM.Results:A total of 409 patients,including 261 LLRs and 148 OLRs,were enrolled in this study.There were imbalances between the groups in baseline information.After 1:1 PSM,118 patients were included in each group with comparable baseline characteristics.Patients in the LLR group had significantly less intraoperative blood loss compared to those in the OLR group(median 223 vs.318 mL,P75×109/L.Conclusions:Compared with OLR,LLR had less intraoperative blood loss,fewer postoperative complications and comparable oncological outcomes for patients with BCLC stage 0/A HCC and CSPH.
基金supported by the National Natural Science Foundation of China(No.42277050)the Fundamental Research Funds for the Central Universities(No.2-9-2022-041).
摘要The chemical reduction of pollutants by Fe2+aq-iron oxides heterogeneous systems is an important component of abiotic natural attenuation.A linear free energy relationship(LFERs)can be established between the reduction potential(EH)of the heterogeneous system and the kinetic parameter(k)of pollutant degradation.However,this relationship was limited to a single iron oxide.The difference in iron oxides particle size and the coexisting anions and cations in groundwater should also be considered.Here,this study investigated the effect of coexisting ions on the nitrobenzene reduction in the Fe2+aq-goethite systems with different particle sizes,and explored the response of LFERs.The results indicated that the standard reduction potential(EHO)of Gt-200 was highest among Gt-200,Gt-700 and Gt-1000.However,the nitrobenzene reduction rate exhibited the highest in the Fe2+aq-Gt-200 heterogenous systems,which was ascribed to the best adsorption affinity of Fe2+aqon Gt-200.Besides,the presence of cations and anions inhibited the reduction rate of nitrobenzene.As for LFERs,the slopes were the same for the Fe2+aq-goethite systems with different particle sizes and coexisting ions.The intercept terms were different.The maximum difference in intercept terms was reduced from 0.98 to 0.37 by correcting the LFERs based on the saturated adsorption capacity of Fe2+aq.The adsorption performance of Fe2+aqon goethite was an important factor affecting the reduction of nitrobenzene.These findings would provide theoretical support for accurately predicting the abiotic natural attenuation rate of nitrobenzene in the presence of coexisting ions in actual groundwater.