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Wavelet-based analysis of aeolian sand dynamics and adaptive mitigation strategies for desert highways 认领 引用
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作者 YANG Lingxiang CHENG Jianjun +3 位作者 YAO Bin WANG Yaqiang GAO Li WU Xiao 《Journal of Mountain Science》 SCIE CSCD 2026年第3期1182-1200,共19页
Scientific analysis of aeolian sand environments is fundamental for sustainable disaster mitigation along desert highways.However,significant regional variability in wind energy conditions complicates accurate charact... Scientific analysis of aeolian sand environments is fundamental for sustainable disaster mitigation along desert highways.However,significant regional variability in wind energy conditions complicates accurate characterization of wind regimes and introduces uncertainty in determining optimal monitoring timescales.Moreover,prevailing sand control measures often rely on standardized designs rather than site-specific adaptive strategies.To address these issues,this study proposes an integrated framework for aeolian environment analysis and develops targeted disaster mitigation strategies tailored for desert highways.The proposed framework employs wavelet transform to unravel the periodic characteristics of wind speed time series and integrates multi-source data(including ERA5 wind datasets,sand samples,ASTER GDEM,and multi-temporal remote sensing imagery)to enable a comprehensive aeolian environmental assessment.Concurrently,a suite of adaptive strategies is formulated to mitigate disaster risks along desert highways.Validated through a case study of the Tumushuk-Kunyu Desert Highway in Xinjiang,China,the framework exhibits high accuracy:predictions of annual aeolian sand transport activity show relative errors mostly below 7%against long-term reference sequences,and the calculated resultant drift direction exhibits a strong correlation with observed dune migration,yielding an R-squared value of 0.96.These findings confirm the framework’s reliability and provide a robust basis for designing adaptive,location-specific mitigation strategies,thereby enhancing the sustainability of desert highway infrastructure. 展开更多
关键词 Desert highway Aeolian sand environment Wavelet transform Drift potential Adaptive mitigation measures
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Facet-induced reduction directed AgBr/Ag0/TiO2{100}Z-scheme heterojunction for tetracycline removal 认领 引用 被引量：2
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作者 Qi Xiong Quanquan Shi +2 位作者 Binli Wang Alfons Baiker Gao Li 《Chinese Journal of Catalysis》 SCIE EI CAS CSCD 2025年第8期164-179,共16页
Given their unique structure-dependent properties,strategically designing semiconductor-based photocatalysts,which expose highly reactive crystalline facets,is widely used to tune their performance.Herein,AgBr/Ag/TiO_... Given their unique structure-dependent properties,strategically designing semiconductor-based photocatalysts,which expose highly reactive crystalline facets,is widely used to tune their performance.Herein,AgBr/Ag/TiO2{100}nanorods Z-scheme heterojunction composites were prepared via hydrothermal and in situ facet-induced reduction.Transmission electron microscopy,X-ray diffraction,X-ray photoelectron spectroscopy,electron paramagnetic resonance spectroscopy,and density functional theory calculations reveal that the selective exposure of TiO2{100}facets with abundant oxygen vacancies(OV)promotes the formation of metallic silver on the interfaces between AgBr and TiO2{100}.Metallic silver can mediate interfacial charge transfer by facilitating the photogenerated carrier recombination of the conduction band of TiO2{100}and the valence band of AgBr.As a result,a Z-scheme heterojunction is formed in AgBr/Ag/TiO2{100}.The AgBr/Ag/TiO2{100}exhibits faster degradation of tetracycline in aqueous solution compared to pristine AgBr,TiO2{101},TiO2{100}and AgBr/TiO2{101}p-n heterojunctions.This is attributed to the effect of the Z-scheme heterojunction on prolonging the lifetime of photogenerated carriers,which is confirmed by femtosecond transient absorption spectroscopy.The photocatalytic mechanism and degradation pathways are discussed along with a toxicity assessment of the intermediates.Overall,this work develops a new approach for designing Z-scheme heterojunction photocatalysts via selective facet control of anatase TiO2. 展开更多
关键词 Facet-induced reduction AgBr/Ag0/TiO2{100} Z-scheme heterostructure Oxygen vacancy Photocatalysis Tetracycline degradation
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Construction of the“Five-Element Synergy”International Talent Training Model for Featured Disciplines 认领 引用
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作者 Guangli Xu Liangxue Cai +1 位作者 Gao Li LingLi Xiong 《Journal of Contemporary Educational Research》 2025年第11期34-40,共7页
The international development of the petroleum industry has posed an urgent demand for the internationalization capabilities of both academic and professional master’s students.However,there is currently a shortage o... The international development of the petroleum industry has posed an urgent demand for the internationalization capabilities of both academic and professional master’s students.However,there is currently a shortage of such talent in the petroleum energy sector,along with a lack of a collaborative training system.Based on this,this study focuses on featured disciplines in the petroleum energy sector and systematically constructs an international talent training model centered around the“five-element synergy”of“government-school-enterprise-teacher-student.”Firstly,it defines the connotations of the five-element synergy:“government(strategic guidance)-school(platform support)-enterprise(demand verification)-teacher(leading transformation)-student(practical co-creation).”Secondly,it sets distinct training objectives for academic(focusing on academic innovation)and professional(emphasizing engineering practice)master’s students.Furthermore,it constructs a“categorized and layered,progressive and collaborative”curriculum system,builds an international faculty team through a“recruitment+training”dual-path approach,and cultivates students’sense of professional mission to“contribute to the nation’s energy sector”through a“macro+micro”perspective.This model provides a practical pathway for international talent training in the petroleum energy sector and holds significant importance for enhancing the overseas competitiveness of petroleum enterprises and safeguarding national energy security. 展开更多
关键词 Energy Five-element synergy International talent Training model
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Impact of International Student Mobility in Distinctive Disciplines on Internationalization Capabilities 认领 引用
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作者 Guangli Xu Liangxue Cai Gao Li 《Journal of Contemporary Educational Research》 2025年第9期1-9,共9页
To deeply analyze the impact of international student mobility on their internationalization capabilities in the field of Petroleum and Natural Gas Engineering,this study systematically reviewed the exchange dynamics ... To deeply analyze the impact of international student mobility on their internationalization capabilities in the field of Petroleum and Natural Gas Engineering,this study systematically reviewed the exchange dynamics of international students at Southwest Petroleum University from 2014 to 2024,as well as detailed data on students’overseas visits from 2016 to 2024,carefully outlining the trends and characteristics of student international mobility over the past decade.Based on this,using an evaluation system for internationalization capabilities constructed by the authors,which closely follows the characteristics of Petroleum and Natural Gas Engineering and covers key dimensions such as language skills,international perspective,cross-cultural communication,and global cooperation,graduate students from the research team of international students were selected as a sample group.Through a carefully designed survey questionnaire,their current internationalization capabilities were systematically evaluated.The results showed that compared to the benchmark level in 2019,students’internationalization capabilities have shown a significant improvement trend,especially in cross-cultural communication.This finding not only reveals the positive role of international student mobility in promoting academic exchanges and integration but also further emphasizes the unique value of multicultural integration in scientific research teams to enhance the internationalization capabilities of domestic students. 展开更多
关键词 International mobility Internationalization capabilities Petroleum and natural gas engineering discipline
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Targeted pH-responsive polyion complex micelle for controlled intracellular drug delivery 认领 引用 被引量：9
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作者 Pan Zheng Yang Liu +3 位作者 Jinjin Chen Weiguo Xu Gao Li Jianxun Ding 《Chinese Chemical Letters》 SCIE CAS CSCD 2020年第5期1178-1182,共5页
Cancer the rapy with nanoscale drug formulations has made significant progress in the past few decades.However,the selective accumulation and release of therapeutic agents in the lesion sites are still great challenge... Cancer the rapy with nanoscale drug formulations has made significant progress in the past few decades.However,the selective accumulation and release of therapeutic agents in the lesion sites are still great challenges.To this end,we developed a cRGD-decorated pH-responsive polyion complex(PIC)micelle for intracellular targeted delivery of doxorubicin(DOX)to upregulate tumor inhibition and reduce toxicity.The PIC micelle was self-assembled via the electrostatic interaction between the positively charged cRGD-modified poly(ethylene glycol)-block-poly(L-lysine)and the anionic acid-sensitive 2,3-dimethylmaleic anhydride-modified doxorubicin(DAD).The decoration of cRGD enhanced the cell internalization of PIC micelle through the specific recognition ofαvβ3 integrin on the membrane of tumor cells.The active DOX was released under intracellular acidic microenvironment after endocytosis following the decomposition of DAD.Moreover,the targeted PIC micelle exhibited enhanced inhibition efficacies toward hepatoma in vitro and in vivo compared with the insensitive controls.The smart multifunctional micelle provides a promising platform for target intracellular delivery of therapeutic agent in cancer therapy. 展开更多
关键词 Polypeptide Targeting pH-responsiveness Intracellular drug delivery Cancer therapy
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Vehicle Detection Based on Visual Saliency and Deep Sparse Convolution Hierarchical Model 认领 引用 被引量：6
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作者 CAI Yingfeng WANG Hai +2 位作者 CHEN Xiaobo GAO Li CHEN Long 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2016年第4期765-772,共8页
Traditional vehicle detection algorithms use traverse search based vehicle candidate generation and hand crafted based classifier training for vehicle candidate verification.These types of methods generally have high ... Traditional vehicle detection algorithms use traverse search based vehicle candidate generation and hand crafted based classifier training for vehicle candidate verification.These types of methods generally have high processing times and low vehicle detection performance.To address this issue,a visual saliency and deep sparse convolution hierarchical model based vehicle detection algorithm is proposed.A visual saliency calculation is firstly used to generate a small vehicle candidate area.The vehicle candidate sub images are then loaded into a sparse deep convolution hierarchical model with an SVM-based classifier to perform the final detection.The experimental results demonstrate that the proposed method is with 94.81%correct rate and 0.78%false detection rate on the existing datasets and the real road pictures captured by our group,which outperforms the existing state-of-the-art algorithms.More importantly,high discriminative multi-scale features are generated by deep sparse convolution network which has broad application prospects in target recognition in the field of intelligent vehicle. 展开更多
关键词 vehicle detection visual saliency deep model convolution neural network
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Fracture sealing performance of granular lost circulation materials at elevated temperature:A theoretical and coupled CFD-DEM simulation study 认领 引用 被引量：7
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作者 Chong Lin Qi-Cong Xu +4 位作者 Lie-Xiang Han Gao Li Hai He Hong-Ling Zhou Ji-Ping She 《Petroleum Science》 SCIE EI CAS CSCD 2024年第1期567-581,共15页
Lost circulation is a common downhole problem of drilling in geothermal and high-temperature,high-pressure(HTHP)formations.Lost circulation material(LCM)is a regular preventive and remedial measure for lost circulatio... Lost circulation is a common downhole problem of drilling in geothermal and high-temperature,high-pressure(HTHP)formations.Lost circulation material(LCM)is a regular preventive and remedial measure for lost circulation.However,conventional LCMs seem ineffective in high-temperature formations.This may be due to the changes in the mechanical properties of LCMs and their sealing performance under high-temperature conditions.To understand how high temperature affects the fracture sealing performance of LCMs,we developed a coupled computational fluid dynamics-discrete element method(CFD-DEM)model to simulate the behavior of granular LCMs in fractures.We summarized the literature on the effects of high temperature on the mechanical properties of LCMs and the rheological properties of drilling fluid.We conducted sensitivity analyses to investigate how changing LCM slurry properties affected the fracture sealing efficiency at increasing temperatures.The results show that high temperature reduces the size,strength,and friction coefficient of LCMs as well as the drilling fluid viscosity.Smaller,softer,and less frictional LCM particles have lower bridging probability and slower bridging initiation.Smaller particles tend to form dual-particle bridges rather than single-particle bridges.These result in a deeper,tighter,but unstable sealing zone.Reduced drilling fluid viscosity leads to faster and shallower sealing zones. 展开更多
关键词 Geothermal well drilling HTHP formationLost circulation material CFD-DEM Fracture sealing
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Influence of Chain Architectures on Crystallization Behaviors of PLLA Block in PEG/PLLA Block Copolymers 认领 引用 被引量：3
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作者 Sheng Xiang Dong-Dong Zhou +4 位作者 Li-Dong Feng Xin-Chao Bian Gao Li Xue-Si Chen Tian-Chang Wang 《Chinese Journal of Polymer Science》 SCIE EI CAS CSCD 2019年第3期258-267,共10页
The effect of the architecture of poly(ethylene glycol)/poly(L-lactide)(PEG/PLLA) block copolymers on the non-isothermal crystallization behaviors of PLLA blocks was investigated by differential scanning calorimetry(D... The effect of the architecture of poly(ethylene glycol)/poly(L-lactide)(PEG/PLLA) block copolymers on the non-isothermal crystallization behaviors of PLLA blocks was investigated by differential scanning calorimetry(DSC) and wide angle X-ray diffraction(WAXD). 1-Arm MPEG-b-PLLA and 4-arm PEG-b-PLLA(4PEG-b-PLLA) were synthesized by the ring-opening polymerization of Llactide in the presence of poly(ethylene glycol) methyl ether(MPEG) and 4-arm poly(ethylene glycol)(4PEG). 4-Arm PLLA-b-MPEG(4PLLA-b-PEG) was synthesized by coupling 4-arm PLLA and MPEG. The WAXD results indicated that the crystalline structure of PLLA blocks did not alter due to the different chain architectures. The average values of Avrami index(ˉn) were all above 4, which indicated that the nucleation mechanism of PLLA blocks was heterogeneous nucleation, regardless of the architectures. The overall crystallization rates were decreased markedly as following: MPEG-b-PLLA > 4PEG-b-PLLA > 4PLLA-b-PEG, ascribed to the different confinement by PEG blocks and to the steric hindrance of chain architectures. Therefore, the crystallization of PLLA blocks became more difficult and the crystallization activation energy of the PLLA blocks increased due to the confinement of chain architectures. 展开更多
关键词 Poly(L-lactide) Poly(ethylene glycol)/poly(L-lactide)block copolymer Non-isothermal crystallization Chain architecture
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A Manganese(Ⅱ) Coordination Polymer Constructed from Phosphonate Ligand:Synthesis,Crystal Structure and Magnetic Properties 认领 引用 被引量：5
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作者 XU Yan LIU Bin +1 位作者 LI Jie GAO Li 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2021年第3期306-310,272,共5页
A coordination polymer formulated as[Mn(5-pncH2)2H2O](1,5-pncH3=5-phosphono-1-naphthalenecarboxylic acid),was hydrothermally synthesized and magnetically characterized.Compound 1 features a three-dimension... A coordination polymer formulated as[Mn(5-pncH2)2H2O](1,5-pncH3=5-phosphono-1-naphthalenecarboxylic acid),was hydrothermally synthesized and magnetically characterized.Compound 1 features a three-dimensional structure in which the inorganic chains of[Mn(O-P-O)]n are cross-linked by the organic groups of phosphonate ligands.Magnetic measurements of 1 indicate that dominant antiferromagnetic interactions are mediated between the MnⅡ centers. 展开更多
关键词 manganese phosphonate ligand crystal structure magnetic properties
Intelligent risk identification of gas drilling based on nonlinear classification network 认领 引用 被引量：3
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作者 Wen-He Xia Zong-Xu Zhao +4 位作者 Cheng-Xiao Li Gao Li Yong-Jie Li Xing Ding Xiang-Dong Chen 《Petroleum Science》 SCIE EI CAS CSCD 2023年第5期3074-3084,共11页
During the transient process of gas drilling conditions,the monitoring data often has obvious nonlinear fluctuation features,which leads to large classification errors and time delays in the commonly used intelligent ... During the transient process of gas drilling conditions,the monitoring data often has obvious nonlinear fluctuation features,which leads to large classification errors and time delays in the commonly used intelligent classification models.Combined with the structural features of data samples obtained from monitoring while drilling,this paper uses convolution algorithm to extract the correlation features of multiple monitoring while drilling parameters changing with time,and applies RBF network with nonlinear classification ability to classify the features.In the training process,the loss function component based on distance mean square error is used to effectively adjust the best clustering center in RBF.Many field applications show that,the recognition accuracy of the above nonlinear classification network model for gas production,water production and drill sticking is 97.32%,95.25%and 93.78%.Compared with the traditional convolutional neural network(CNN)model,the network structure not only improves the classification accuracy of conditions in the transition stage of conditions,but also greatly advances the time points of risk identification,especially for the three common risk identification points of gas production,water production and drill sticking,which are advanced by 56,16 and 8 s.It has won valuable time for the site to take correct risk disposal measures in time,and fully demonstrated the applicability of nonlinear classification neural network in oil and gas field exploration and development. 展开更多
关键词 Gas drilling Intelligent identification of drilling risk Nonlinear classification RBF Neural Network K-means algorithm
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Mathematical modeling of heat transfer in counter-current multiphase flow found in gas-drilling systems with formation fluid influx 认领 引用 被引量：2
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作者 Boyun Guo Jun Li +1 位作者 Jinze Song Gao Li 《Petroleum Science》 SCIE CAS CSCD 2017年第4期711-719,共9页
The performance of gas-drilling(drilling oil and gas wells with air, nitrogen, or natural gas) is very unpredictable in many areas due to lack of proper design of drilling parameters because of limited understanding o... The performance of gas-drilling(drilling oil and gas wells with air, nitrogen, or natural gas) is very unpredictable in many areas due to lack of proper design of drilling parameters because of limited understanding of gas–rock interaction which requires knowledge of heat transfer in the well system. Complete analysis of rock failure requires an accurate mathematical model to predict gas temperature at the bottom hole. The currently available mathematical models are unsuitable for use for the purpose because they do not consider the effects of formation fluid influx, Joule–Thomson cooling, and entrained drill cuttings. A new analytical solution for predicting gas temperature profiles inside the drill string and in the annulus was derived in this study for gas-drilling, considering all these three effects. Results of sensitivity analyses show that formation fluid influx can significantly increase the temperature profiles in both the drill string and the annulus.The Joule–Thomson cooling effect lowers the temperature in the annulus only in a short interval near the bottom hole.The drill cuttings entrained at the bottom hole can slightly increase the temperature profile in the annulus. 展开更多
关键词 Gas-drilling Temperature Prediction Influx Joule–Thomson Cuttings
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Non-metallic gold nanoclusters for oxygen activation and aerobic oxidation 认领 引用 被引量：6
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作者 Guomei Zhang Ruru Wang Gao Li 《Chinese Chemical Letters》 SCIE CAS CSCD 2018年第5期687-693,共7页
In recent decade, Au nanoclusters of atomic precision （AunLm, where L= organic ligand： thiolate andphosphine） have been shown as a new promising nanogold catalyst. The well-defined AunLm catalystspossess unique ele... In recent decade, Au nanoclusters of atomic precision （AunLm, where L= organic ligand： thiolate andphosphine） have been shown as a new promising nanogold catalyst. The well-defined AunLm catalystspossess unique electronic properties and frameworks, providing an excellent opportunity to correlate theintrinsic catalytic behavior with the cluster＇s framework as well as to study the catalytic mechanismsover gold nanoclusters. In this review, we only demonstrate the important roles of the gold nanoclustersin the oxygen activation （e.g., 302 to 102） and their selective oxidations in the presence of oxygen （e.g., COto C02, sulfides to sulfoxides, alcohol to aldehyde, styrene to styrene epoxide, amines to imines, andglucose to gluconic acid）. The size-specificity （Au25 （1.3 nm）, Au38 （].5 nm）, Au144 （1.9 nm）, etc.）, ligandengineering （e.g., aromatic vs aliphatic）, and doping effects （e.g., copper, silver, palladium, and platinum）are discussed in details. Finally, the proposed reactions＇ mechanism and the relationships of clusters＇structure and activity at the atomic level also are presented. 展开更多
关键词 Gold nanocluster Oxygen activation Aerobic oxidation Size-specificity Ligand engineering Doping effects
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A Reversible Data Hiding with Quality Controllable Scheme for Encrypted-Compressed Image 认领 引用
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作者 LI Xinyan MOU Huajian +1 位作者 YAN Bing GAO Li 《Wuhan University Journal of Natural Sciences》 CAS CSCD 2019年第5期383-390,共8页
In order to achieve image encryption and data embedding simultaneously, a reversible data hiding(RDH) algorithm for encrypted-compressed image in wavelet domain is proposed. This scheme employs the quality controllabl... In order to achieve image encryption and data embedding simultaneously, a reversible data hiding(RDH) algorithm for encrypted-compressed image in wavelet domain is proposed. This scheme employs the quality controllable parameter. Moreover it has larger embedding capacity and smaller quality control parameters than other methods in literatures. Meanwhile, the cross chaotic map is employed to generate chaotic sequences, and the total keys of the algorithm is far large. Experimental results and comparisons show that the proposed scheme has large capacity, high security, and strong resistance to brute-force. 展开更多
关键词 reversible data hiding in encrypted image cross chaotic map diffuse and scramble encryption-compression
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Total flavonoids from Anchusa italica improves cardiac function and attenuates cardiac remodeling post-myocardial infarction in mice 认领 引用
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作者 WANG Shou-bao SONG Jun-ke +5 位作者 WANG Rong-rong GAO Li ZHANG Li FANG Lian-hua LYU Yang DU Guan-hua 《中国药理学与毒理学杂志》 CAS 北大核心 2019年第9期698-699,共2页
OBJECTIVE The plant of Anchusa italicahas been traditionally used in Uighur medicine for the treatment of cardiovascular and cerebrovascular diseases in China.Our previous study showed that total flavonoids from Anchu... OBJECTIVE The plant of Anchusa italicahas been traditionally used in Uighur medicine for the treatment of cardiovascular and cerebrovascular diseases in China.Our previous study showed that total flavonoids from Anchusa italica(TFAI)exhibited potent cardioprotection on acute ischemiaeperfusion injured rats.This study was undertaken to investigate the effects of TFAI on chronic myocardial infarction in mice and the underlying mechanism.METHODS Total flavonoids were extracted from the whole herb of Anchusa italica and were characterized using HPLC-MS analysis.The left anterior descending branch of coronary artery was ligated to induce myocardial infarction in mice.After surgery,the mice were orally fed with TFAI at the doses of 10,30 and 50 mg·kg-1 body mass per day for a total of four weeks.Cardiac function and infarct size were measured,and the levels of inflammatory mediators were detected.Hematoxylin and eosin(HE)stain and Masson Trichrome stain were performed.The apoptotic factors such as Bax,Bcl-2 and cleaved caspase 3 as well as the key proteins in the PI3K/Akt/mTOR signaling pathway were examined by Western blotting.RESULTS The content of total flavonoids in TFAI was 56.2%.Four weeks following the MI surgery,TFAI enhanced the survival rate in post-MI mice.TFAI administration at the doses of 30 and 50 mg·kg-1 significantly reduced the infarct size and improved cardiac function indicated by elevated EF and FS.Assay of inflammation factors showed that the sera levels of TNF-α,IL-1β and IL-6 were significantly decreased by TFAI treatment as compared to the MI group.HE stain and Masson Trichrome stain demonstrated that TFAI suppressed myocyte hypertrophy and cardiac fibrosis indicated by decreased cross-section area and collagen volume.Western blot analysis showed that cleaved caspase 3 and Bax/Bcl-2 were signifi⁃cantly downregulated following TFAI treatment.Additionally,TFAI treatment significantly suppressed the activation of the PI3K/Akt/mTOR signaling pathway.CONCLUSION TFAI exerts a protective effect against chronic myocardial infarction and its beneficial effects on cardiac function and cardiac remodeling might be at least attributable to anti-inflammation and suppression of the PI3K/Akt/mTOR signaling pathway. 展开更多
关键词 total flavonoids Anchusa italica cardiac function
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Simplified Markov Model for Reliability Analysis of Phased-Mission System Using States Merging Method 认领 引用
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作者 YAN Hua GAO Li +1 位作者 QI Lei WAN Ping 《Journal of Shanghai Jiaotong university(Science)》 EI 2018年第3期418-422,共5页
This paper presents a simplified Markov model to evaluate the reliability of phased-mission system(PMS). The time cost and storage requirement are very huge for traditional Markov model to analyze the PMS reliability ... This paper presents a simplified Markov model to evaluate the reliability of phased-mission system(PMS). The time cost and storage requirement are very huge for traditional Markov model to analyze the PMS reliability as the number of components increases to a large scale. The states merging method proposed in this paper can account for the PMS with subsystems consisting of identical components, and similar PMSs are common in real-world systems. The simplified Markov model by states merging has smaller number of system states, compared with the traditional one. Furthermore, for the above subsystems, the size of our model increases only linearly as the number of components increases, while the size of the traditional model exponentially increases.Finally, the effectiveness and correctness of our approach are analyzed by comparing with the traditional Markov method. 展开更多
关键词 phased-mission system(PMS) reliability evaluation continuous time Markov chains simplified model
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Cryptoporic acid E from Cryptoporusvolvatus inhibits influenza virus replication in vitro 认领 引用
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作者 GAO Li HAN Jia-yuan +2 位作者 WANG Jun-chi SI Jian-yong CAO Li 《中国药理学与毒理学杂志》 CAS CSCD 北大核心 2016年第10期1091-1092,共2页
Influenza virus infection is a global public health issue.The effectiveness of antiviral agents for influenza has been limited by the emergence of drugresistant virus strains.Therefore,there is an urgent need to ident... Influenza virus infection is a global public health issue.The effectiveness of antiviral agents for influenza has been limited by the emergence of drugresistant virus strains.Therefore,there is an urgent need to identify novel antiviral therapies.Our previous studies have found that Cryptoporus volvatus extract could potently inhibit influenza virus replication in vitro and in vivo.However,the effective component of Cryptoporus volvatus which mediated the antiviral activity hasn′t been identified.Here,we identified a novel anti-influenza molecule,cryptoporic acid E(CAE),from Cryptoporus volvatus.Our results showed that CAE had broad-spectrum anti-influenza activity against 2009 pandemic strain A/Beijing/07/2009(H1N1/09),seasonal strain A/Jiangxi/262/05(H3N2),mouse adapted strains A/WSN/33(H1N1)and A/PR8/34(H1N1).We further investigated the mode of CAE action,and found that CAE directlyattenuated influenza virus infectivity.Time-course-analysis indicated that CAE exerted its inhibition mainly at middle stage of the replication cycle of influenza virus.Subsequently,we confirmed that CAE blocked virus RNA replication and transcription in MDCK cells and CAE repressed influenza virus RNA polymerase activity.In addition,we found that CAE impaired influenza virus infectivity by directly targeting virus particles.Our data suggest that CAE is a major effective component of Cryptoporus volvatus and might be a potential candidate for the development of a new anti-influenza virus therapy. 展开更多
关键词 cryptoporic acid E anti-influenza virus effective component in vitro
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Application and Assessment of Ketamine-Xylidinothiazoline Combinations for Anaesthesia in Rhesus Monkey 认领 引用
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作者 XIAO Jianhua GAO Li +4 位作者 Liu Huanqi FAN Honggang MA Haikun LIU Yun WANG Hongbin 《Journal of Northeast Agricultural University(English Edition)》 CAS 2009年第1期45-50,共6页
The quantitative anaesthesia assessment technique was used to evaluate the effectiveness of ketamine, ketamine-xylidinothiazoline in rhesus monkey. Total 20 healthy adult rhesus monkeys were divided into two groups an... The quantitative anaesthesia assessment technique was used to evaluate the effectiveness of ketamine, ketamine-xylidinothiazoline in rhesus monkey. Total 20 healthy adult rhesus monkeys were divided into two groups and anaesthetized using either intramuscular （IM） ketamine （20 mg·kg^-1） or ketamine （5 mg·kg^-1 IM） and xylidinothiazoline （1 mg·kg^-1 IM）. During anaesthesia rectal temperature, respiratory rate, heart rate, saturation of blood oxygen and blood pressure were recorded. The degree of sedation, analgesia, muscle relaxation were monitored either. The results showed that ketamine alone did not produce adequate anaesthesia, and the combination of xylidinothiazoline and ketamine provided adequate anesthesia for rhesus monkeys with no significant side effects and little effects on respiration and circulation. 展开更多
关键词 anaesthesia rhesus monkey ketamine xylidinothiazoline
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CFRP修复钢Ⅰ/Ⅱ混合型裂纹扩展研究进展及展望 认领 引用 被引量：3
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作者 高立 邓宗才 《工程力学》 EI CSCD 北大核心 2026年第1期11-27,共17页
钢结构在循环荷载作用下往往会发生疲劳破坏。由于结构的复杂性和荷载形式的复合性,往往会使钢结构产生Ⅰ/Ⅱ混合型裂纹,且疲劳裂纹修复一直是钢结构疲劳研究的热点。碳纤维增强聚合物复合材料(Carbon fiber reinforced polymer,CFRP)... 钢结构在循环荷载作用下往往会发生疲劳破坏。由于结构的复杂性和荷载形式的复合性,往往会使钢结构产生Ⅰ/Ⅱ混合型裂纹,且疲劳裂纹修复一直是钢结构疲劳研究的热点。碳纤维增强聚合物复合材料(Carbon fiber reinforced polymer,CFRP)在修复钢结构中有诸多优势和良好的应用前景,目前的研究主要集中于Ⅰ型裂纹的修复,但对于Ⅰ/Ⅱ混合型裂纹扩展及其修复的研究比较少。为此,从疲劳裂纹扩展、裂纹扩展速率和等效应力强度因子的计算方法方面报道了混合模态下钢材的裂纹扩展研究现状;重点阐述了CFRP修复混合型裂纹扩展现状,分析了CFRP基础材性、CFRP-钢界面粘结性能和不同裂纹角度等因素对混合裂纹修复的性能影响;基于目前的研究现状对CFRP修复钢结构在疲劳荷载作用下混合型裂纹扩展的应用前景和研究重点进行了展望。 展开更多
关键词 结构工程 混合裂纹 CFRP 裂纹扩展速率 等效应力强度因子 界面性能
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生物炭对鬼针草根际土壤养分循环的影响 认领 引用 被引量：1
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作者 李艺 高莉 +5 位作者 覃潇潇 傅伊昀 石东弋 兰威 唐颖璇 于方明 《中国环境科学》 EI CAS CSCD 北大核心 2026年第1期279-288,共10页
以鬼针草为研究对象,通过盆栽实验,分析了铁-钙层状双氢氧化物玉米秸秆生物炭(Fe-Ca LDH-CSB)添加对鬼针草根际土壤养分循环的影响.结果表明,Fe-Ca LDH-CSB添加显著提高了土壤C/N和土壤有机质含量(P<0.05),与对照相比,分别增加31.1%~... 以鬼针草为研究对象,通过盆栽实验,分析了铁-钙层状双氢氧化物玉米秸秆生物炭(Fe-Ca LDH-CSB)添加对鬼针草根际土壤养分循环的影响.结果表明,Fe-Ca LDH-CSB添加显著提高了土壤C/N和土壤有机质含量(P<0.05),与对照相比,分别增加31.1%~45.6%和3.6%~10.3%.同时,Fe-Ca LDH-CSB添加促进了碳、氮和磷循环相关功能基因的表达.在生物炭添加为2.0%(质量比)的处理下,与对照相比,碳固定相关基因(如fbaA、korA、sucC和accD等)的丰度提高了1.1~1.4倍;氮循环相关基因(如GDH2、nosZ、nifH和hao等)提高了1.7~23.5倍;磷循环相关基因(如ppk1、ppa、TC.PIT和pstB等)提高了1.1~1.2倍.Mantel分析结果表明,土壤有效磷含量与碳、氮和磷循环功能基因均呈显著正相关关系(P<0.01);蔗糖酶活性与碳和氮循环功能基因呈正相关关系(P<0.01),与磷循环功能基因呈负相关关系(P<0.05).偏最小二乘路径模型结果进一步表明,Fe-Ca LDH-CSB的施用改变了土壤理化性质和功能微生物的丰度,从而调控了土壤中功能基因的表达水平.变形菌门、放线菌门和绿弯菌门细菌是鬼针草根际土壤中碳、氮和磷循环关键功能基因的主要宿主.Fe-Ca LDH-CSB添加通过影响鬼针草根际土壤相关理化性质,改变土壤微生物群落组成,驱动碳、氮、磷循环相关功能基因的表达,从而影响根际土壤的养分循环过程. 展开更多
关键词 鬼针草 层状双氢氧化物生物炭 养分循环 宏基因组 根际微生物
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Relations among homogeneity, collapsibility and nonconfounding in distribution effects 认领 引用
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作者 WANG Xue-li GAO Li 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE 2010年第3期291-296,共6页
In this paper, the concept of distribution effect is proposed without the causal diagram. Following the notation of Stone [11], we assume that the exposure treatment X is an unknown deterministic function of the confo... In this paper, the concept of distribution effect is proposed without the causal diagram. Following the notation of Stone [11], we assume that the exposure treatment X is an unknown deterministic function of the confounder set Pa（X） and a random error ε. We discuss sufficient and necessary conditions for homogeneity, collapsibility and nonconfounding for distribution effects and discuss relations among them. 展开更多
关键词 Collapsibility confounding homogeneity distribution effect.
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