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Exploring the clinical implications of novel SRD5A2 variants in 46,XY disorders of sex development 认领 引用
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作者 Yu Mao Jian-Mei Huang +7 位作者 Yu-Wei Chen-Zhang He Lin Yu-Huan Zhang Ji-Yang Jiang Xue-Mei Wu Ling Liao Yun-Man Tang Ji-Yun Yang 《Asian Journal of Andrology》 SCIE CAS CSCD 2025年第2期211-218,共8页
This study was conducted retrospectively on a cohort of 68 patients with steroid 5α-reductase 2(SRD5A2)deficiency and 46,XY disorders of sex development(DSD).Whole-exon sequencing revealed 28 variants of SRD5A2,and f... This study was conducted retrospectively on a cohort of 68 patients with steroid 5α-reductase 2(SRD5A2)deficiency and 46,XY disorders of sex development(DSD).Whole-exon sequencing revealed 28 variants of SRD5A2,and further analysis identified seven novel mutants.The preponderance of variants was observed in exon 1 and exon 4,specifically within the nicotinamide adenine dinucleotide phosphate(NADPH)-binding region.Among the entire cohort,53 patients underwent initial surgery at Sichuan Provincial People’s Hospital(Chengdu,China).The external genitalia scores(EGS)of these participants varied from 2.0 to 11.0,with a mean of 6.8(standard deviation[s.d.]:2.5).Thirty patients consented to hormone testing.Their average testosterone-todihydrotestosterone(T/DHT)ratio was 49.3(s.d.:23.4).Genetic testing identified four patients with EGS scores between 6 and 9 as having this syndrome;and their T/DHT ratios were below the diagnostic threshold.Furthermore,assessments conducted using the crystal structure of human SRD5A2 have provided insights into the potential pathogenic mechanisms of these novel variants.These mechanisms include interference with NADPH binding(c.356G>C,c.365A>G,c.492C>G,and c.662T>G)and destabilization of the protein structure(c.727C>T).The c.446-1G>T and c.380delG variants were verified to result in large alterations in the transcripts.Seven novel variations were identified,and the variant database for the SRD5A2 gene was expanded.These findings contribute to the progress of diagnostic and therapeutic approaches for individuals with SRD5A2 deficiency. 展开更多
关键词 ambiguous genitalia disorders of sex development micro-penis sex determination SRD5A2 deficiency
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Temperature-Dependent Infrared Engineering for Extreme Environments:All-Dielectric Thermal Photonic Metamaterials Stable at 1873 K in Air 认领 引用
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作者 Yang Liu He Lin +5 位作者 Yunxia Zhou Liming Yuan Yanqin Wang Xiaoliang Ma Cheng Huang Xiangang Luo 《Nano-Micro Letters》 SCIE EI CAS CSCD 2026年第6期879-897,共19页
The development of infrared engineering technologies for extreme environments remains a formidable challenge due to the inherent trade-offs among optical performance,thermal stability,and mechanical integrity in therm... The development of infrared engineering technologies for extreme environments remains a formidable challenge due to the inherent trade-offs among optical performance,thermal stability,and mechanical integrity in thermal photonic metamaterials(TPMs).This work introduces a novel multi-obj ective design framework and demonstrates the design,fabrication,and validation of a TPM operating under extreme temperatures up to 1873 K.We have established a holistic design framework integrating temperaturedependent neural network and Pareto multi-obj ective optimization to co-optimize spectral response,component light-weighting,and structural efficiency.The framework achieves 100 times faster computation than genetic algorithms.The performance of the designed TPM was evaluated under various atmospheric models and detection distances.The TPM achieved a peak radiance suppression efficiency of 82%and a maximum attenuation of-7.4 dB at 1200-1500 K.Experimentally,we fabricated an all-dielectric TPM using a refractory TiO2/BeO multilayer stack with only 5 layers and 2um total thickness.The optimized structure shows high reflectivity(0.62 at 3-5 um;0.48 at 8-14μm)for radiative suppression and high emissivity(0.87 at 5-8μm)for radiative cooling.The TPM withstands 1873 K for 12 h in air with less than 3%spectral drift,retaining excellent mechanical properties.On high-temperature components,it achieves 40-50%radiative suppression and 40-60 K(~10.1 kW m-2)radiative cooling at 1100 K,endures over 20 times thermal shock cycles(>150 K s-1,700-1500 K),and maintains stable performance over 5 cycles,with 78%visible and 98%microwave transmittance.This work establishes a new paradigm in the design and application of photonic materials for extreme environments. 展开更多
关键词 Extreme environment Thermal photonic Metamaterial Machine learning Thermal management
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Fault diagnosis method of AC motor rolling bearing based on heterogeneous data fusion of current and infrared image 认领 引用 被引量：5
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作者 LIU Peijin GUO Zichen +2 位作者 HE Lin YAN Dongyang ZHANG Xiangrui 《Journal of Measurement Science and Instrumentation》 CAS CSCD 2024年第4期558-570,共13页
In order to improve the accuracy of rolling bearing fault diagnosis when the motor is running under non-stationary conditions,an AC motor rolling bearing fault diagnosis method was proposed based on heterogeneous data... In order to improve the accuracy of rolling bearing fault diagnosis when the motor is running under non-stationary conditions,an AC motor rolling bearing fault diagnosis method was proposed based on heterogeneous data fusion of current and infrared images.Firstly,VMD was used to decompose the motor current signal and extract the low-frequency component of the bearing fault signal.On this basis,the current signal was transformed into a two-dimensional graph suitable for convolutional neural network,and the data set was classified by convolutional neural network and softmax classifier.Secondly,the infrared image was segmented and the fault features were extracted,so as to calculate the similarity with the infrared image of the fault bearing in the library,and further the sigmod classifier was used to classify the data.Finally,a decision-level fusion method was introduced to fuse the current signal with the infrared image signal diagnosis result according to the weight,and the motor bearing fault diagnosis result was obtained.Through experimental verification,the proposed fault diagnosis method could be used for the fault diagnosis of motor bearing outer ring under the condition of load variation,and the accuracy of fault diagnosis can reach 98.85%. 展开更多
关键词 current signal infrared image decision level fusion rolling bearing fault diagnosis
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Prediction of Extreme Air Temperature and Wind Speed Along the Northern Sea Route(NSR)with Application for the Safety of Polar Vessels 认领 引用
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作者 CHAI Wei QI Jian-zhang +3 位作者 HE Lin Bernt J.LEIRA Chana SINSABVARODOM SHU Ya-qing 《China Ocean Engineering》 SCIE EI CSCD 2025年第4期744-754,共11页
Due to global warming and diminishing ice cover in Arctic regions,the northern sea route(NSR)has attracted increasing attention in recent years.Extreme cold temperatures and high wind speeds in Arctic regions present ... Due to global warming and diminishing ice cover in Arctic regions,the northern sea route(NSR)has attracted increasing attention in recent years.Extreme cold temperatures and high wind speeds in Arctic regions present substantial risks to vessels operating along the NSR.Consequently,analyzing extreme temperature and wind speed values along the NSR is essential for ensuring maritime operational safety in the region.This study analyzes wind and temperature data spanning 40 years,from 1981 to 2020,at four representative sites along the NSR for extreme value analysis.The average conditional exceedance rate(ACER)method and the Gumbel method are employed to estimate extreme wind speed and air temperature at these sites.Comparative analysis reveals that the ACER method provides higher accuracy and lower uncertainty in estimations.The predicted extreme wind speed for a 100-year return period is 30.36 m/s,with a minimum temperature of-56.66°C,varying across the four sites.Furthermore,the study presents extreme values corresponding to each return period,providing temperature extremes as a basis for guiding steel thickness specifications.These findings provide valuable reference for designing polar vessels and offshore structures,contributing to enhanced engineering standards for Arctic conditions. 展开更多
关键词 northern sea route(NSR) air temperature wind speed extreme value prediction ACER method
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Repetitive control without inductance decoupling for VSR control strategy of DC charging pile 认领 引用
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作者 LIU Peijin SUN Changhe +2 位作者 HE Lin ZHANG Xiangrui FENG Zhengming 《Journal of Measurement Science and Instrumentation》 CAS CSCD 2025年第1期96-106,共11页
A control strategy of repetitive control without inductorance decoupling was proposed to address the problem of high total harmonic distortion(THD)rate of the network-side current caused by the reduced stability of th... A control strategy of repetitive control without inductorance decoupling was proposed to address the problem of high total harmonic distortion(THD)rate of the network-side current caused by the reduced stability of the rectifier module of the DC charging pile under weak grid as well as the dead zone and nonlinearity of switching devices during charging.Firstly,the parallel repetitive control was constructed in the inner current loop,and the proportional-integral(PI)+repetitive controller based on parallel structure was designed.For system compensation,a second-order low-pass filter was selected to correct the system,and the network-side current harmonics were actively suppressed without increasing the filtering device,which effectively improves the quality of grid-connected current.Secondly,based on the synthetic vector method,the controller parameters were designed to realize the elimination of main pole by establishing two synchronous rotation coordinate system vector differential equations,so as to realize the inductanceless decoupling to cope with the influence of network-side inductance fluctuation on the stability of the control system under weak grid.By theoretical analysis and simulation,the proposed control strategy was embedded into the self-developed digital signal processor for the rectifier module of DC charging pile,simulated dynamic and steady-state operation experiments were conducted,and comparative analysis was performed to prove the feasibility of the proposed control strategy. 展开更多
关键词 weak grid DC charging pile voltage source rectifier(VSR) repetitive control inductanceless decoupling
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Thick-Film Negative-Temperature-Coefficient Thermistors with a Linear Resistance-Temperature Relation 认领 引用 被引量：1
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作者 LING Zhi-Yuan HE Lin 《Chinese Physics Letters》 SCIE EI CAS CSCD 2013年第10期143-146,共4页
The effect of the resistance R of Mn1.85Co0.3Ni0.85O4(MCN)thick-film negative-temperature-coefficient(NTC)thermistors on temperature T is studied carefully.Interestingly,the R–T relation is found to be decided simult... The effect of the resistance R of Mn1.85Co0.3Ni0.85O4(MCN)thick-film negative-temperature-coefficient(NTC)thermistors on temperature T is studied carefully.Interestingly,the R–T relation is found to be decided simultaneously by the characteristic of the MCN oxide and the electrode structure of the NTC thermistor.For plane end electrodes,the R–T relation is nonlinear.However,for plane fork electrodes,the R–T relation can be linear.To clarify the intrinsic mechanism of the linear R–T relation,the electric field distribution in the MCN thick film is simulated.The obtained results suggest that the non-uniform electric field distribution between the electrodes is responsible for the R–T relation linearization. 展开更多
关键词 film relation linearization
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Late Cenozoic Sedimentary Evolution of Pagri-Duoqing Co graben, Southern End of Yadong-Gulu Rift, Southern Xizang 认领 引用 被引量：4
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作者 HA Guanghao WU Zhonghai +1 位作者 HE Lin WANG Shubing 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2018年第3期972-987,共16页
The north trending rifts in southern Xizang represent the E-W extension of the plateau and confirming the initial rifting age is key to the study of mechanics of these rifts.Pagri-Duoqing Co graben is located at south... The north trending rifts in southern Xizang represent the E-W extension of the plateau and confirming the initial rifting age is key to the study of mechanics of these rifts.Pagri-Duoqing Co graben is located at southern end of Yadong-Gulu rift,where the late Cenozoic sediments is predominately composed of fluvio-lacustrine and moraine.Based on the sedimentary composition and structures,the fluviolacustrine could be divided into three facies,namely,lacustrine,lacustrine fan delta and alluvial fan.The presence of paleo-currents and conglomerate components and the provenance of the strata around the graben indicate that it was Tethys Himalaya and High Himalaya.Electron spin resonance(ESR)dating and paleo-magnetic dating suggest that the age of the strata ranges from ca.1.2 Ma to ca.8 Ma.Optically stimulated luminescence(OSL)dating showed that moraine in the graben mainly developed from around181-109 ka(late Middle Pleistocene).Combining previous data about the Late Cenozoic strata in other basins,it is suggested that 8-15 Ma may be the initial rifting time.Together with sediment distribution and drainage system,the sedimentary evolution of Pagri could be divided into four stages.The graben rifted at around 15-8 Ma due to the eastern graben-boundary fault resulting in the appearance of a paleolake.Following by a geologically quiet period about 8-2.5 Ma,the paleolake expanded from east to west at around 8-6 Ma reaching its maximum at ca.6 Ma.Then,the graben was broken at about 2.5 Ma.At last,the development of the glacier separated the graben into two parts that were Pagri and Duoqing Co since the later stages of the Middle Pleistocene.The evolution process suggested that the former three stages were related to the tectonic movement,which determined the basement of the graben,while the last stage may have been influenced by glacial activity caused by climate change. 展开更多
关键词 north trending rifts initial rifting age Late Cenozoic strata sedimentary evolution OSL ESR and paleomagnetic dating Xizang China
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Controlling Reactivity of Palladium Amides for Selective Carbonylation towards Urea and Oxamide Derivatives 认领 引用 被引量：4
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作者 WANG Jin-hui CAO Yan-wei HE Lin 《分子催化（中英文）》 CAS CSCD 北大核心 2024年第4期297-308,共12页
Carbonylation reactions,crucial for carbonyl group incorporation,struggle with the inherent complexity of achieving selective mono-or double-carbonylation on single substrates,often due to competing reaction pathways.... Carbonylation reactions,crucial for carbonyl group incorporation,struggle with the inherent complexity of achieving selective mono-or double-carbonylation on single substrates,often due to competing reaction pathways.Herein,our study introduces a strategy employing palladium amides,harnessing their unique reactivity control,to direct the selective carbonylation of amines for the targeted synthesis of urea and oxamide derivatives.The palladium amide structure was elucidated using single-crystal X-ray diffraction.Controlled experiments and cyclic voltammetry studies further elucidate that the oxidation of palladium amide or its insertion into a carbonyl group diverges into distinct pathways.By employing sodium percarbonate as an eco-friendly oxidant and base,we have successfully constructed a switchable carbonylation system co-catalyzed by palladium and iodide under room temperature.The utilizing strategy in this study not only facilitates effective control over reaction selectivity but also mitigates the risk of explosions,a critical safety concern in traditional carbonylation methods. 展开更多
关键词 selectivity control palladium catalysis oxidative carbonylation aminocarbonylation green reagents
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A novel model of drug cue-induced behaviours in rhesus macaque subjected to chronic ketamine exposure 认领 引用 被引量：2
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作者 Meng Qin Jiaoqiong Guan +7 位作者 Yichun Huang He Lin Ding Cui Tao Yao Chaoyang Tian Mali Wong Zhe Shi Tifei Yuan 《General Psychiatry》 CSCD 2023年第1期76-78,共3页
To the Editor,Non-human primate(NHP)models are advantageous for mimicking human addiction with high behavioural validity.1 However,current NHP drug addiction models(eg,self-administration)often require a comprehensive... To the Editor,Non-human primate(NHP)models are advantageous for mimicking human addiction with high behavioural validity.1 However,current NHP drug addiction models(eg,self-administration)often require a comprehensive behavioural training paradigm,relatively expensive apparatus and invasive surgical procedures. 展开更多
关键词 drug behaviour ketamine
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The role of AtGPDHc2 in regulating cellular redox homeostasis of Arabidopsis under salt stress 认领 引用 被引量：1
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作者 ZHAO Ying LIU Meng +5 位作者 WANG Feng DING Dong ZHAO Chang-jiang HE Lin LI Zuo-tong XU Jing-yu 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2019年第6期1266-1279,共14页
Plants glycerol-3-phosphate dehydrogenase(GPDH)catalyzes the formation of glycerol-3-phosphate,and plays an essential role in glycerolipid metabolism and stress responses.In the present study,the knock-out mutants of ... Plants glycerol-3-phosphate dehydrogenase(GPDH)catalyzes the formation of glycerol-3-phosphate,and plays an essential role in glycerolipid metabolism and stress responses.In the present study,the knock-out mutants of cytosolic GPDH(AtGPDHc2)and wild-type Arabidopsis plants were treated with 0,50,100,and 150 mmol L–1 NaCl to reveal the effects of AtGPDHc2 deficiency on salinity stress responses.The fluctuation in redox status,reactive oxygen species(ROS)and antioxidant enzymes as well as the transcripts of genes involved in the relevant processes were measured.In the presence of 100 and 150 mmol L–1 NaCl treatments,AtGPDHc2-deficient plants exhibited a pronounced reduction in germination rate,fresh weight,root length,and overall biomass.Furthermore,loss of AtGPDHc2 resulted in a significant perturbation in cellular redox state(NADH/NAD+and AsA/DHA)and consequent elevation of ROS and thiobarbituric acid-reactive substances(TBARS)content.The elevated ROS level triggered substantial increases in ROS-scavenging enzymes activities,and the up-regulated transcripts of the genes(CSD1,sAPX and PER33)encoding the antioxidant enzymes were also observed.In addition,the transcript levels of COX15,AOX1A and GLDH in gpdhc2 mutants decreased in comparison to wild-type plants,which demonstrated that the deficiency of AtGPDHc2 might also has impact on mitochondrial respiration under salt stress.Together,this work provides some new evidences on illustrating the roles of AtGPDHc2 playing in response to salinity stress by regulating cellular redox homeostasis,ROS metabolism and mitochondrial respiration. 展开更多
关键词 Arabidopsis thaliana glycerol-3-phosphate dehydrogenase(GPDH) redox homeostasis reactive oxygen species(ROS) respiration
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Laser powder bed fusion of biodegradable Zn-4 Cu alloy:Processing,microstructure and properties 认领 引用
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作者 WANG Han-dan ZHAO Yang +3 位作者 DONG An-ping HE Lin SHUAI Ci-jun GAO Cheng-de 《Journal of Central South University》 SCIE EI CAS CSCD 2026年第1期66-77,共12页
Zn's natural degradability and biocompatibility make it a promising candidate for implants,however,its mechanical properties remain insufficient for bone applications.In this study,the performance of Zn was enhanc... Zn's natural degradability and biocompatibility make it a promising candidate for implants,however,its mechanical properties remain insufficient for bone applications.In this study,the performance of Zn was enhanced by developing Zn-Cu alloys via laser powder bed fusion(LPBF).Optimal LPBF parameters for forming stable tracks were achieved by adjusting laser power and scanning speed.Under optimized conditions of 100 W and 100 mm/s,high density(99.58%)Zn-Cu alloys with improved hardness(68.2 HV)and yield strength(160 MPa)were achieved.These improvements are attributed to solid solution strengthening,segregation strengthening,and grain refinement.The Zn-Cu alloys also demonstrated favorable degradation behavior,with a rate of 0.16 mm/year.This degradation is primarily driven by micro-galvanic corrosion between the CuZn 5 phase and Zn matrix,along with refined grains and increased grain boundary density.This work demonstrates a viable strategy for fabricating Zn-based implants with enhanced structural integrity and mechanical performance via LPBF. 展开更多
关键词 laser powder bed fusion(LPBF) Zn-Cu alloys microstructure mechanical properties biodegradation
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Initial Rifting Age of the Nearly N–S Rifts in Southern Tibetan Plateau:New Evidence from the Age limit of the Early Sediments 认领 引用 被引量：2
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作者 HA Guanghao WU Zhonghai +1 位作者 HE Lin WANG Shubing 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2017年第2期739-740,共2页
Objective The nearly parallel N-S-trending rifts in southern Tibet represent the E-W extension of the Tibet Plateau. Most data which constrained the age of the extensional deformation come from isotopic dating of the ... Objective The nearly parallel N-S-trending rifts in southern Tibet represent the E-W extension of the Tibet Plateau. Most data which constrained the age of the extensional deformation come from isotopic dating of the dikes probably related to the activity of the nearly N-S faulting and micas from hydrothermal activity and the low- temperature thermochronology of plateau uplift. Previous research shows that there are at least three different ideas about the age of the rifts： （1） older than 16-12 Ma, （2） 14- 10 Ma, and （3） 8-4 Ma （Fig. la）. For the old sedimentary strata represented the beginning of the rifting, the dating of the sediments helps to better define the initial rifting age. 展开更多
关键词 Initial Rifting Age of the Nearly N S Rifts in Southern Tibetan Plateau:New Evidence from the Age limit of the Early Sediments
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Local structural characteristics of Sb_2Te_3 films studied by reverse Monte Carlo modeling 认领 引用
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作者 Ling Zhang San-Nian Song +5 位作者 He Lin Yan Cheng Wei Xi Le Li Yan He Zhi-Tang Song 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2017年第3期91-96,共6页
Atomic configuration and connectivity of Sb_2Te_3 thin film are investigated using high-energy X-ray diffraction and reverse Monte Carlo simulation. Atomic model details of Sb_2Te_3 thin film are compared with liquid ... Atomic configuration and connectivity of Sb_2Te_3 thin film are investigated using high-energy X-ray diffraction and reverse Monte Carlo simulation. Atomic model details of Sb_2Te_3 thin film are compared with liquid and amorphous Sb_2Te_3 reported in other article. Simulations show that both Sb–Sb and Te–Te homopolar bonds are present in the models. In phase transition process,atomic configuration of the sample rearranges gradually through the forming of Sb–Te bonds and the breaking of Sb–Sb and Te–Te bonds. 展开更多
关键词 Phase-change material Reverse Monte Carlo Atomic configuration
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APCDD1 as a Co-receptor Positively Regulates Wnt5a/c-Jun Non-Canonical Signaling Pathway 认领 引用
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作者 WANG Lei TAO Yixin +4 位作者 ZHANG Jie WANG Xiaoqing ZHOU Shanghui HE Lin MA Gang 《Journal of Shanghai Jiaotong university(Science)》 EI 2019年第4期510-516,共7页
Adenomatosis polyposis down-regulated 1(APCDD1) is a transmembrane glycoprotein that negatively regulates Wnt/β-catenin canonical signaling by binding with Wnt ligands and receptors. We analyzed the role of APCDD1 in... Adenomatosis polyposis down-regulated 1(APCDD1) is a transmembrane glycoprotein that negatively regulates Wnt/β-catenin canonical signaling by binding with Wnt ligands and receptors. We analyzed the role of APCDD1 in the Wnt5a/c-Jun non-canonical signaling pathway and demonstrated that APCDD1 can interact in vitro with Wnt5a, a classical ligand, and Ror2, a receptor of non-canonical Wnt signaling. Furthermore, we verified the binding of APCDD1 and Ror2 in primary cells of mouse skin. Moreover, APCDD1 seems to form a complex with Ror2 and Vangl2 in the cell, and complex formation can be improved by adding Wnt5a. In the presence of Wnt5a and Ror2, APCDD1 can induce the phosphorylation of c-Jun, a transcription factor of Wnt5a non-canonical signaling, and its phosphorylation level is a readout of Wnt5 a signaling. Wound-healing assay shows that APCDD1 accelerates polarized cell migration during Wnt5a-induced wound closure. Therefore,it is very likely that APCDD1 regulates Wnt5a/c-Jun non-canonical signaling as co-receptor binding with both Wnt5a and Ror2. 展开更多
关键词 adenomatosis polyposis down-regulated 1 (APCDD1) Wnt signaling receptor Wnt5a polarized cell migration
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Effects of Dasatinib on the Maturation of Monocyte-Derived Dendritic Cells Derived from Healthy Donors and Chronic Myelogenous Leukemia Patients 认领 引用
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作者 CAO Wan-Jun DAI Jing-Ying +7 位作者 DONG Wen-Juan WANG Xi WANG Xiao-Dong XIA Jing-Yi LI Xiao-Hua ZHOU Hua CHEN Jie HE Lin 《中国实验血液学杂志》 CAS CSCD 北大核心 2022年第3期677-687,共11页
Objective:To investigate the effects of dasatinib on the maturation of monocyte-derived dendritic cells(moDCs)derived from healthy donors(HDs)and chronic myelogenous leukemia(CML)patients.Methods:Peripheral blood mono... Objective:To investigate the effects of dasatinib on the maturation of monocyte-derived dendritic cells(moDCs)derived from healthy donors(HDs)and chronic myelogenous leukemia(CML)patients.Methods:Peripheral blood mononuclear cells(PBMCs)were isolated from HDs(n=10)and CML patients(n=10)who had got the remission of MR4.5 with imatinib treatment.The generation of moDCs from PBMCs was completed after 7 days of incubation inDC I culture medium,and another 3 days of incubation in DC II culture medium with or without 25nmol/L dasatinib.On the 10th day,cells were harvested and expression of molecules of maturation related marker were assessed by flow cytometry.The CD80*CD86’cell population in total cells was gated as DCs in the fluorescence-activated cell storting(FACS)analyzing system,then the expression of CD83,CD40 or HLA-DR in this population was analyzed respectively.Results:The proportion of CD80*CD86*cells in total cells didn't show a statistical difference between HD group and patient group(89.46%±9.70%vs 87.39%±9.34%,P=0.690).Dasatinib significantly enhanced the expression of the surface marker CD40(P=0.008)and HLA-DR(P=0.028)on moDCs derived from HDs compared with the control group,while the expression of CD83 on moDCs didn't show a significant difference between dasatinib group and the control group(P=0.428).Meanwhile,dasatinib significantly enhanced the expression of the surface marker CD40(P=0.023),CD83(P=0.038)and HLA-DR(P=0.001)on moDCs derived from patients compared with the control group.Conclusion:ForCML patients,the same high proportion of moDCs as HDs can be induced in vitro,which provides a basis for the application of DC-based immunotherapy strategy.Dasatinib at the concentration of 25nmol/L can efficiently promote the maturation of moDCs derived from HDs and CML patients in vitro.Dasatinib shows potential as a DC adjuvant to be applied in DC-based immunotherapy strategies,such as DC vaccine and DC cell-therapy. 展开更多
关键词 dasatinib immunomodulatory effect dentritic cells cell maturation dendritic cell adjuvant
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Design, synthesis and antitumor activity evaluation of novel 2,6-dichloro-3,5-dinitrotoluene derivatives 认领 引用
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作者 Jiayuan Jiao Hao Hu +3 位作者 Siyuan Wei Wanqiu Wang He Lin Baoshan Chai 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2018年第3期159-169,共11页
A series of novel 2,6-dichloro-3,5-dinitrotoluene derivatives were designed, synthesized in the present study, and their antitumor activities against five cell lines（A431, HepG2, A549, HT-29 and HEK-293） were tested... A series of novel 2,6-dichloro-3,5-dinitrotoluene derivatives were designed, synthesized in the present study, and their antitumor activities against five cell lines（A431, HepG2, A549, HT-29 and HEK-293） were tested. Most of the compounds exhibited moderate-to-significant cytotoxicity and high selectivity against one or more cell lines in comparison with cisplatin. Studies on their preliminary structure-activity relationships（SARs） indicated that compounds containing phenyl（piperazin-1-yl） methanone groups, especially chlorine atom at 4-position of the phenyl ring, were more effective. Compound 4g was found to be the most potent derivative with IC_（50） values of 1.04, 3.20, 6.93, 4.10 and 20.15 μmol/L against A431, HepG2, A549, HT-29 and HEK-293 cell lines, respectively, which was better than positive control cisplatin, one of the most clinically used chemotherapeutic drugs. 展开更多
关键词 2,6-Dichloro-3,5-dinitrotoluene Cytotoxic activity Structure-activity relationships
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海上风力机响应极值预报研究进展综述 认领 引用 被引量：1
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作者 柴威 何林 +3 位作者 施伟 陈威 曾佳焱 杨清泉 《太阳能学报》 EI CAS CSCD 北大核心 2026年第3期308-315,共8页
综述海上风力机响应极值预报的研究进展,重点介绍基于统计分析和机器学习的极值预报方法。统计方法包括渐进极值法、阈值超越法、平均穿越率法和平均条件超越率法。统计方法通过样本数据建模风力机响应的概率分布模型,进行极值预报。基... 综述海上风力机响应极值预报的研究进展,重点介绍基于统计分析和机器学习的极值预报方法。统计方法包括渐进极值法、阈值超越法、平均穿越率法和平均条件超越率法。统计方法通过样本数据建模风力机响应的概率分布模型,进行极值预报。基于机器学习的极值预报方法(如人工神经网络和高斯过程回归等算法),通过提取数据特征并构建非线性模型,进行海上风力机响应极值预报,最后对各类极值预报方法的优缺点及适用场景进行总结,并展望极值预报技术的未来发展方向。 展开更多
关键词 海上风力机 响应 极值预报 统计方法 机器学习 代理模型
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Dynamic Characteristics of Double-Helical Planetary Gear Sets Under Time-Varying Mesh Stiffness 认领 引用 被引量：3
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作者 He Lin Sanmin Wang +2 位作者 Earl HDowell Jincheng Dong Cong Ma 《Journal of Harbin Institute of Technology(New Series)》 CAS 2016年第4期44-51,共8页
Internal and external meshes are two of primary excitation sources which induce vibration while double-helical planetary gear sets are in transmission. Based on the analysis of tooth movement principle,three cases of ... Internal and external meshes are two of primary excitation sources which induce vibration while double-helical planetary gear sets are in transmission. Based on the analysis of tooth movement principle,three cases of mesh stiffness are derived via investigating the length of action lines,and catalogued in terms of β β_0. The simulation demonstrates mesh stiffness between gear pairs performs as a trapezoid waveform( TW) and changes along with the line of action simultaneously,total mesh stiffness comes from the superposition of each engaged gear. While governing equations of motion contained 16 DOFs( degree of freedom) are constructed and effectively solved through the combination of numerical approaches. Comparing with sinusoidal waveform mesh stiffness( SW),the results show that dynamical factors and perturbation under the excitation of TW( β < β_0) are greater and remarkable than that from SW,with respect to the mean dynamic factors about 1. 51 and 1. 28,respectively. The fluctuation response between ring- planet( R- P) is stronger than sun-planet( S-P) which is also validated by both approach studies,frequency spectra analyses identifies larger distinct rotational resonance and more frequencies under TW excitation. 展开更多
关键词 time-varying mesh stiffness trapezoid waveform mean dynamical factors frequency spectra
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面向城市复杂环境视觉地点识别算法研究 认领 引用
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作者 刘沛津 张闽心 +2 位作者 何林 孙艺阁 苏庭琪 《系统仿真学报》 EI CAS CSCD 北大核心 2026年第3期818-828,共11页
针对复杂城市环境中交通流量、人群密度等动态因素降低视觉地点识别(visual place recognition,VPR)算法精度的问题,提出一种融合语义引导的视觉地点识别(semantic-guided VPR,SG-VPR)算法。设计语义引导特征抑制模块,通过构建语义引导... 针对复杂城市环境中交通流量、人群密度等动态因素降低视觉地点识别(visual place recognition,VPR)算法精度的问题,提出一种融合语义引导的视觉地点识别(semantic-guided VPR,SG-VPR)算法。设计语义引导特征抑制模块,通过构建语义引导模块与特征抑制层弱化动态物体干扰,精准提取关键静态特征;改进传统三元损失函数,提出自适应三元损失函数(adaptive triplet marginal loss,ATML),依据样本分布自适应调整边距,解决固定边距策略导致的次优解收敛问题,提升特征区分能力。实验结果表明:SG-VPR算法在Pittsburgh250k和Tokyo24/7城市复杂环境公开数据集上的表现优于现有方法,在动态干扰场景下的视觉地点识别性能得到提升。 展开更多
关键词 城市复杂环境 视觉地点识别 深度学习 语义引导 特征抑制 自适应三元损失函数
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Low-temperature chemistry in plasma-driven ammonia oxidative pyrolysis 认领 引用 被引量：1
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作者 Mingming Zhang Qi Chen +2 位作者 Guangzhao Zhou Jintao Sun He Lin 《Green Energy & Environment》 SCIE EI CAS CSCD 2024年第9期1477-1488,共12页
Ammonia is gaining increasing attention as a green alternative fuel for achieving large-scale carbon emission reduction. Despite its potential technical prospects, the harsh ignition conditions and slow flame propagat... Ammonia is gaining increasing attention as a green alternative fuel for achieving large-scale carbon emission reduction. Despite its potential technical prospects, the harsh ignition conditions and slow flame propagation speed of ammonia pose significant challenges to its application in engines. Non-equilibrium plasma has been identified as a promising method, but current research on plasma-enhanced ammonia combustion is limited and primarily focuses on ignition characteristics revealed by kinetic models. In this study, low-temperature and low-pressure chemistry in plasma-assisted ammonia oxidative pyrolysis is investigated by integrated studies of steady-state GC measurements and mathematical simulation. The detailed kinetic mechanism of NH3 decomposition in plasma-driven Ar/NH3 and Ar/NH3/O2 mixtures has been developed. The numerical model has good agreements with the experimental measurements in NH3/O2 consumption and N2/H2 generation, which demonstrates the rationality of modelling. Based on the modelling results, species density profiles, path flux and sensitivity analysis for the key plasmaproduced species such as NH2, NH, H2, OH, H, O, O(1D), O2(a1△g), O2(b1∑g+), Ar*, H-, Ar+, NH3+, O2- in the discharge and afterglow are analyzed in detail to illustrate the effectiveness of the active species on NH3 excitation and decomposition at low temperature and relatively higher E/N values. The results revealed that NH2, NH, H as well as H2 are primarily generated through the electron collision reactions e + NH3→ e + NH2+ H, e + NH3→ e + NH + H2 and the excited-argon collision reaction Ar* + NH3+ H → Ar + NH2+ 2H, which will then react with highly reactive oxidative species such as O2*, O*, O, OH, and O2 to produce stable products of NOx and H2O. NH3→ NH is found a specific pathway for NH3 consumption with plasma assistance, which further highlights the enhanced kinetic effects. 展开更多
关键词 Non-equilibrium plasma Ammonia fuel Oxidative pyrolysis Pathway flux analysis Sensitivity analysis
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