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Spatial transcriptome analysis of long non-coding RNAs reveals tissue specificity and functional roles in cancer 认领 引用 被引量：2
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作者 Kang XU Xiyun JIN +8 位作者 Ya LUO Haozhe ZOU Dezhong LV Liping WANG Limei FU Yangyang CAI Tingting SHAO Yongsheng LI Juan XU 《Journal of Zhejiang University-SCIENCE B》 SCIE CAS CSCD 2023年第1期15-31,共17页
Long non-coding RNAs(lncRNAs)play a significant role in maintaining tissue morphology and functions,and their precise regulatory effectiveness is closely related to expression patterns.However,the spatial expression p... Long non-coding RNAs(lncRNAs)play a significant role in maintaining tissue morphology and functions,and their precise regulatory effectiveness is closely related to expression patterns.However,the spatial expression patterns of lncRNAs in humans are poorly characterized.Here,we constructed five comprehensive transcriptomic atlases of human lncRNAs covering thousands of major tissue samples in normal and disease states.The lncRNA transcriptomes exhibited high consistency within the same tissues across resources,and even higher complexity in specialized tissues.Tissue-elevated(TE)lncRNAs were identified in each resource and robust TE lncRNAs were refined by integrative analysis.We detected 1 to 4684 robust TE lncRNAs across tissues;the highest number was in testis tissue,followed by brain tissue.Functional analyses of TE lncRNAs indicated important roles in corresponding tissue-related pathways.Moreover,we found that the expression features of robust TE lncRNAs made them be effective biomarkers to distinguish tissues;TE lncRNAs also tended to be associated with cancer,and exhibited differential expression or were correlated with patient survival.In summary,spatial classification of lncRNAs is the starting point for elucidating the function of lncRNAs in both maintenance of tissue morphology and progress of tissue-constricted diseases. 展开更多
关键词 Spatial expression Transcriptome Long non-coding RNA Cancer Biomarker
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The Impact of Digital Economy on Enterprises’Green Technological Innovation 认领 引用
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作者 Limei Fu Duorijie Zhuoma 《Proceedings of Business and Economic Studies》 2026年第6期224-233,共10页
Against the backdrop of the coordinated advancement of Digital China construction and the dual carbon goals,exploring the enabling effect of the digital economy on the green transformation of micro-enterprises is of g... Against the backdrop of the coordinated advancement of Digital China construction and the dual carbon goals,exploring the enabling effect of the digital economy on the green transformation of micro-enterprises is of great theoretical and practical significance.Based on the resource-based view and information asymmetry theory,this paper takes China’s Shanghai and Shenzhen A-share listed companies from 2013 to 2023 as research samples and constructs an enterprise digital economy development index.Adopting a two-way fixed effect model,this paper empirically examines the impact of the digital economy on corporate green technological innovation.The research results show that the digital economy can significantly promote enterprises’green technological innovation,and the conclusion remains valid after a series of robustness tests including substituting explained variables,lagging core explanatory variables,and Tobit model regression.Heterogeneity analysis indicates that the driving effect of the digital economy is more prominent in non-state-owned enterprises and heavily polluting industries.Mechanistically,the digital economy alleviates information asymmetry and financing constraints,thereby stimulating green R&D investment and innovation output.This paper finally puts forward targeted policy suggestions on improving digital infrastructure,implementing differentiated incentive policies,and promoting the integration of digital and real economies,which provides empirical evidence for the coordinated realization of high-quality economic development and ecological environmental improvement. 展开更多
关键词 Digital economy Green technological innovation Enterprise heterogeneity Two-way fixed effect model
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Construction of Vocational Education Quality Evaluation Index System from the Perspective of Digital Transformation Based on the Analytic Hierarchy Process of Higher Vocational Colleges in Hainan Province,China 认领 引用 被引量：3
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作者 Limei Fu 《Journal of Contemporary Educational Research》 2025年第1期282-289,共8页
In the context of the digital transformation of vocational education,a quality evaluation index system has been constructed.Based on a questionnaire survey conducted among higher vocational colleges and enterprises in... In the context of the digital transformation of vocational education,a quality evaluation index system has been constructed.Based on a questionnaire survey conducted among higher vocational colleges and enterprises in Hainan Province,it has been found that the quality of vocational education generally depends on the talent training program and professional construction at the macro level.At the meso level,the teacher level and teaching environment are critical,while at the micro level,the evaluation of talent training quality cannot be underestimated.Strategies for quality improvement in vocational education are proposed from the perspectives of talent training programs,major construction,teacher development,teaching environment,and talent training quality,all under the lens of digital transformation. 展开更多
关键词 Digital transformation Vocational education Evaluation index system
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Does the Reduction of Financing Cost in Digital Economy Promote the Green Technology Innovation of Enterprises? Analysis Based on Mediating Effect 认领 引用
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作者 Limei Fu 《Proceedings of Business and Economic Studies》 2025年第8期106-114,共9页
Using simulated panel data,this study investigates the impact of the digital economy on corporate green technology innovation and its mediating role through financing costs.The empirical results demonstrate that the d... Using simulated panel data,this study investigates the impact of the digital economy on corporate green technology innovation and its mediating role through financing costs.The empirical results demonstrate that the digital economy significantly enhances green innovation.It effectively reduces corporate financing costs,which in turn positively drives green innovation,a significant mediating effect.The study also reveals that firm size,profitability,industry type,and regional economic levels significantly moderate the digital economy’s role in promoting green innovation.Robustness tests confirm the reliability of the findings.This research provides a micro-level mechanism explanation for how the digital economy fosters green innovation and offers policy implications. 展开更多
关键词 Digital economy Green technology innovation Financing cost Intermediary effect Firm heterogeneity
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Research on the Construction and Application of Intelligent Financial Decision-Making Model Driven by Generative Artificial Intelligence 认领 引用
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作者 Limei Fu 《Proceedings of Business and Economic Studies》 2025年第4期77-83,共7页
This study focuses on the construction and application of intelligent financial decision-making models driven by generative artificial intelligence(AI).It analyzes the mechanisms by which generative AI empowers financ... This study focuses on the construction and application of intelligent financial decision-making models driven by generative artificial intelligence(AI).It analyzes the mechanisms by which generative AI empowers financial decision-making within a dual framework of dynamic knowledge evolution and risk control.The research reveals that generative AI,with its superior data processing,pattern recognition,and autonomous learning capabilities,can transcend the limitations of traditional decision-making models,facilitating a significant shift from causal inference to probabilistic creation in decision-making paradigms.By systematically constructing an intelligent financial decision-making model that includes data governance,core engine,and decision output layers,the study clarifies the functional roles and collaborative mechanisms of each layer.Additionally,it addresses key challenges in technology application,institutional adaptation,and organizational transformation by proposing systematic strategies for technical risk management,institutional innovation,and organizational capability enhancement,aiming to provide robust theoretical support and practical guidance for the intelligent transformation of corporate financial decision-making. 展开更多
关键词 Generative artificial intelligence Intelligent financial decision making Decision model Risk control
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Research on the Influence of Digital Economy on the Income Gap between Urban and Rural Areas in China 认领 引用 被引量：1
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作者 Limei Fu 《Proceedings of Business and Economic Studies》 2024年第5期194-199,共6页
In recent years,with the rapid advancement of information technology and the widespread proliferation of the Internet,digital technology has been reshaping the value chains of traditional industries and giving rise to... In recent years,with the rapid advancement of information technology and the widespread proliferation of the Internet,digital technology has been reshaping the value chains of traditional industries and giving rise to entirely new business models and industrial forms.Technologies such as the Internet,big data,and artificial intelligence are being applied across various sectors,while new formats like e-commerce,the sharing economy,and online education are flourishing.These developments have driven new consumption patterns and employment methods.The rapid rise of the digital economy not only boosts production efficiency and economic growth but also influences the income distribution between urban and rural areas to some extent.This paper begins by examining the current state and characteristics of the digital economy and then analyzes its impact on the urban-rural income gap.Additionally,it offers countermeasures and recommendations for narrowing this gap,providing theoretical support for promoting common prosperity. 展开更多
关键词 Digital economy Urban-rural income gap Impact Countermeasures
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Research on the Influence of Equity Structure on Corporate Performance 认领 引用
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作者 Limei Fu 《Proceedings of Business and Economic Studies》 2024年第1期127-132,共6页
Equity structure constitutes a crucial component of corporate internal governance.A scientifically and reasonably structured equity system aids in enhancing the level and efficiency of corporate governance.Through emp... Equity structure constitutes a crucial component of corporate internal governance.A scientifically and reasonably structured equity system aids in enhancing the level and efficiency of corporate governance.Through empirical analysis of data spanning from 2013 to 2022,the study aims to verify the influence mechanism of equity structure on corporate performance.The results indicate that enhancing equity concentration and balance positively impacts corporate performance,with this effect persisting over time.Consequently,optimizing the degree of equity concentration,shareholder types,and the board of directors’structure can assist enterprises in maximizing long-term value. 展开更多
关键词 Equity structure Corporate performance Corporate governance
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Research on the Development Strategy of Smart Tourism in Hainan Under the Background of Big Data 认领 引用
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作者 Limei Fu 《Journal of Contemporary Educational Research》 2024年第4期108-113,共6页
Hainan is a major tourist province.It is urgent to promote the transformation and upgrading of Hainan’s tourism industry from a traditional service industry to a modern service industry by means of informatization.Sm... Hainan is a major tourist province.It is urgent to promote the transformation and upgrading of Hainan’s tourism industry from a traditional service industry to a modern service industry by means of informatization.Smart tourism is a brand-new tourism form and operation mode of tourism transformation and upgrading.Integrating big data technology will make smart tourism more accurate in three aspects:tourism management,tourism service,and tourism marketing,and further enhance the satisfaction of the tourism experience.This paper studies the development status of smart tourism in Hainan,deeply summarizes its existing problems and causes,and puts forward the development strategy of smart tourism in Hainan to promote the healthy development of the tourism industry in Hainan. 展开更多
关键词 Big data Smart tourism Development strategy
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Rich Connotation,Realistic Dilemma,and Practical Path of Teachers’Digital Literacy in the Era of Digital Intelligence 认领 引用
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作者 Limei Fu 《Journal of Contemporary Educational Research》 2023年第10期98-104,共7页
With the rapid development of information technology and the popularity of the Internet,digital education has become an important direction of modern education reform.Digital education provides a new way and tool for ... With the rapid development of information technology and the popularity of the Internet,digital education has become an important direction of modern education reform.Digital education provides a new way and tool for education and teaching,so that teachers and students can make better use of the application of information technology in the teaching process.Teachers’digital literacy has become the key to realize digital education.In the digital age,the level of teachers’digital literacy directly affects teachers’teaching effect and students’learning results.Therefore,improving teachers’digital literacy has become an urgent task of education reform. 展开更多
关键词 Digital literacy Teacher development Practice path
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Green Finance Promotes High-Quality Development of Regional Economy 认领 引用
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作者 Huanhuan Wang Limei Fu 《Proceedings of Business and Economic Studies》 2024年第2期157-162,共6页
With the rapid development of the social economy,the role of green finance in promoting the high-quality development of regional economies is increasing day by day.The advancement of green finance not only aids in fos... With the rapid development of the social economy,the role of green finance in promoting the high-quality development of regional economies is increasing day by day.The advancement of green finance not only aids in fostering the green transformation and upgrading of regional economies but also helps mitigate the risks of environmental damage stemming from traditional economic activities.In this new era,it is imperative to embrace the concept of green finance development and innovate green finance practices to further drive high-quality regional economic development.This paper will analyze the significance of green finance in regional economic development,assess the current state of green finance development,and propose optimization strategies for green finance to facilitate high-quality economic development. 展开更多
关键词 Green finance Regional economy High-quality development
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