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Integrating high-resolution mass spectrometry and transcriptomics to explore the therapeutic mechanism of Sanhuang Oil in diabetic foot 认领 引用
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作者 Ping Sun Yu-Feng Zhang +4 位作者 Shuang Li Wei Zhang Peng-Fei Zhao Chen-Xia Li Chen-Ning Zhang 《Traditional Medicine Research》 2026年第1期19-38,共20页
Background:Diabetic foot,a severe complication of diabetes,is characterized by chronic refractory wounds.Sanhuang Oil,a topical herbal formula,demonstrates significant therapeutic effects including antibacterial,anti-... Background:Diabetic foot,a severe complication of diabetes,is characterized by chronic refractory wounds.Sanhuang Oil,a topical herbal formula,demonstrates significant therapeutic effects including antibacterial,anti-inflammatory,and immunomodulatory activities.However,its active constituents and mechanisms of action against diabetic foot remain to be elucidated.Methods:In this study,the chemical constituents of Sanhuang Oil were identified using UPLC-QE-Orbitrap-MS.Subsequently,the mechanism by which Sanhuang Oil promotes diabetic foot ulcer healing was predicted by integrating network pharmacology and molecular docking.Additionally,diabetic mouse model was established in ICR mice using a combination of a high-fat diet(HFD)and streptozotocin(STZ)chemical induction.A full-thickness skin defect was created on the dorsum of the mice.Wound healing and the healing rate were observed following Sanhuang Oil intervention.The mechanism underlying Sanhuang Oil’s promotion of diabetic ulcer healing was further investigated using transcriptomics and histopathological examination(H&E staining).Results:A total of 97 active ingredients were identified from Sanhuang Oil.Network pharmacology analysis predicted 543 common targets,and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis identified 203 relevant pathways.Molecular docking further confirmed high binding affinity(binding energy≤−5.0 kcal/mol)between specific active components in Sanhuang Oil(e.g.,coptisine,phellodendrine,baicalein)and key targets associated with diabetic foot ulcers(e.g.,EGFR,AKT1,STAT3).In vivo experimental results demonstrated that the wound healing rate was significantly higher in Sanhuang Oil-treated groups compared to the model group(P<0.001).HE staining revealed that the high-dose Sanhuang Oil group exhibited more pronounced epithelial tissue coverage over the wound,reduced inflammatory cell infiltration,and increased collagen deposition and fibroblast proliferation.transcriptomic analysis identified Pdk4,Ttn,Csrp3,Actn2,Myoz2,Tnnc2,Myod1,Myog,Myot,and Myf6 as key regulatory proteins involved in promoting wound healing.Conclusion:Sanhuang Oil promotes wound healing in diabetic ulcer mice,potentially by mitigating inflammation and regulating key targets such as Pdk4 to enhance fibroblast function.These findings provide novel insights into the multi-target,multi-pathway mechanism of Sanhuang Oil for treating diabetic foot ulcers. 展开更多
关键词 Sanhuang Oil diabetic foot high-resolution mass spectrometry molecular network analysis mechanism of action
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Comparison of efficacy and safety of a proposed biosimilar QL1206 with reference denosumab in patients with bone metastasis from breast cancer:A subgroup analysis of a randomized,double-blinded phase Ⅲ study 认领 引用
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作者 Yaxin Liu Ruyan Zhang +21 位作者 Xiaojia Wang Lijun Di Zhendong Chen Jingfen Wang Tao Sun Qingshan Li Jing Cheng Qingyuan Zhang Xiuwen Wang Junye Wang Kangsheng Gu Shihong Wei Shuqun Zhang Xiangcai Wang Ping Sun Chunfang Hao Aimin Zang Yujie Li Cuicui Han Xiaoyan Kang Yanling Li Huiping Li 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2025年第3期337-351,共15页
Objective:To evaluate the efficacy and safety of QL1206(a denosumab biosimilar to Xgeva■)in breast cancer patients with bone metastasis(BM)through subgroup analysis of a randomized,double-blind phaseⅢtrial(No.NCT045... Objective:To evaluate the efficacy and safety of QL1206(a denosumab biosimilar to Xgeva■)in breast cancer patients with bone metastasis(BM)through subgroup analysis of a randomized,double-blind phaseⅢtrial(No.NCT04550949).Methods:This subgroup analysis included patients with BM from breast cancer enrolled in a phaseⅢtrial.Patients were randomized(1:1)to receive either three cycles of QL1206 or denosumab(120 mg subcutaneously every 4 weeks).Subsequently,they received 10 cycles of QL1206(120 mg)over 40 weeks,followed by a 20-week safety follow-up.The primary endpoint was the percentage changes from baseline to week 13 in urinary Ntelopeptide corrected for creatinine(u NTx/Cr).Results:The breast cancer cohort consisted of 311 patients.Vertebral involvement(66.4%)was the most prevalent BM site at enrollment,while 27.7%of patients presented with≥3 metastatic bone lesions.At week 13,QL1206 demonstrated a median u NTx/Cr reduction of-69.9%(range:-98.1%-568.0%)vs.-74.3%(range:-97.7%-386.3%)for denosumab.The analysis of covariance revealed comparable least-square means for log-transformed changes:-1.416[95%confidence interval(95%CI):-1.736 to-1.096]vs.-1.501(95%CI:-1.824 to-1.178),yielding an between-group difference of 0.085(90%CI:-0.062-0.232;P=0.343).After a 53-week treatment period,83.6%achieved bone density improvement/disease stabilization.Safety profiles were comparable between groups.Conclusions:QL1206 demonstrated similar efficacy and safety to the reference denosumab in patients with BM from breast cancer,supporting QL1206 as a new option for management of BM from breast cancer. 展开更多
关键词 Bone metastasis breast cancer denosumab QL1206 receptor activator of NF-kB ligand(RANKL) urinary N-telopeptide corrected for creatinine
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VcLOB107 acts as an important regulator of fruit firmness differences between firm and soft flesh blueberries 认领 引用
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作者 Qiaoyu Huang Jiajia Dong +6 位作者 Yiting Hu Xiaoying Lu Yongqiang Li Lishan Xu Ping Sun Yu Zong Weidong Guo 《Fruit Research》 2025年第1期198-210,共13页
Fruit firmness is a significant trait for blueberry breeding as it affects machinery harvest,consumer preference,and transportability.LOB transcription factors play a vital role in the development of lateral organs an... Fruit firmness is a significant trait for blueberry breeding as it affects machinery harvest,consumer preference,and transportability.LOB transcription factors play a vital role in the development of lateral organs and growth in higher plants;yet,few studies on LOB transcription factors have been reported in blueberries.We performed a genome-wide identification analysis of the blueberry LOB gene family.Using fruit at different developmental stages from the firm-flesh cultivar'Star',and the soft-flesh cultivar'O'Neal',the fruit firmness,polygalacturonase(PG)activity,and pectin content of different types were detected.A total of 150 VcLOB genes were identified in the blueberry genome,unevenly distributed across 46 chromosomes.They could be divided into six subfamilies,with members in each subfamily sharing similar gene structures and motifs.Based on the transcriptomic data and fruit firmness of two blueberry cultivars,four VcLOB genes functioning during the critical period of fruit firmness variation were selected,and their expression patterns were dissected,revealing differences in the expression pattern across various tissues and throughout the fruit development stages in blueberries.The fruit firmness of'O'Neal'is significantly lower than that of'Star'from stages S5 to S8 during fruit development.Additionally,the PG activity and water-soluble pectin content in'O'Neal'is significantly higher than those in'Star'.VcLOB107 overexpressed tomato plants exhibited notably higher fruit firmness,lower PG activity,and WSP content compared to the control group,indicating VcLOB107 is a regulator of fruit firmness differences between firm and soft flesh blueberries. 展开更多
关键词 lob transcription factors transcription factors development lateral organs polygalacturonase activity blueberries pectin content fruit firmness vclob genes
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糖基转移酶CsUGT73B4和CsUGT85K5在茶树响应低温胁迫中的分子机制 认领 引用
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作者 盖新月 王晓东 +4 位作者 范延艮 李斌 傅晓东 孙平 黄晓琴 《植物学报》 CAS CSCD 北大核心 2026年第3期402-415,共14页
近年来,UGTs基因在植物响应非生物胁迫中的作用被逐渐揭示。基于转录组数据,筛选出2个在低温胁迫下显著上调,且与茶树(Camellia sinensis)花青苷合成相关的糖基转移酶基因CsUGT73B4(CSS0039619)和CsUGT85K5(CSS0047548)。为探究这2个基... 近年来,UGTs基因在植物响应非生物胁迫中的作用被逐渐揭示。基于转录组数据,筛选出2个在低温胁迫下显著上调,且与茶树(Camellia sinensis)花青苷合成相关的糖基转移酶基因CsUGT73B4(CSS0039619)和CsUGT85K5(CSS0047548)。为探究这2个基因在响应低温胁迫下调控茶树花青苷代谢的分子机制,克隆了CsUGT73B4和CsUGT85K5并进行生物信息学分析,通过拟南芥(Arabidopsis thaliana)过表达和茶树瞬时沉默实验验证其功能。结果显示,低温胁迫下CsUGT73B4/CsUGT85K5基因的表达与花青苷积累呈正相关;过表达拟南芥植株的花青苷含量和抗氧化酶活性显著提高,丙二醛含量和相对电导率则显著下降;在茶树中瞬时沉默CsUGT73B4或CsUGT85K5后,花青苷含量及其合成相关基因的表达水平均显著下调。该研究初步探讨了茶树CsUGT73B4和CsUGT85K5基因的功能,揭示了其通过调控花青苷代谢提高茶树抗寒性的分子机制,为茶树抗寒分子育种提供了相关候选基因。 展开更多
关键词 茶树 低温胁迫 糖基转移酶 花青苷
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Epigenetic factors associated with peri-implantitis:a review 认领 引用 被引量：1
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作者 Qianhui LI Hongye LU +3 位作者 Mengyuan ZHANG Yuting YE Qianming CHEN Ping SUN 《Journal of Zhejiang University-SCIENCE B》 SCIE CAS CSCD 2025年第7期657-674,共18页
Peri-implant diseases are characterized by the resorption of hard tissue and the inflammation of soft tissue.Epigenetics refers to alterations in the expression of genes that are not encoded in the DNA sequence,influe... Peri-implant diseases are characterized by the resorption of hard tissue and the inflammation of soft tissue.Epigenetics refers to alterations in the expression of genes that are not encoded in the DNA sequence,influencing diverse physiological activities,including immune response,inflammation,and bone metabolism.Epigenetic modifications can lead to tissue-specific gene expression variations among individuals and may initiate or exacerbate inflammation and disease predisposition.However,the impact of these factors on peri-implantitis remains inconclusive.To address this gap,we conducted a comprehensive review to investigate the associations between epigenetic mechanisms and peri-implantitis,specifically focusing on DNA methylation and microRNAs(miRNAs or miRs).We searched for relevant literature on PubMed,Web of Science,Scopus,and Google Scholar with keywords including“epigenetics,”“peri-implantitis,”“DNA methylation,”and“microRNA.”DNA methylation and miRNAs present a dynamic epigenetic mechanism operating around implants.Epigenetic modifications of genes related to inflammation and osteogenesis provide a new perspective for understanding how local and environmental factors influence the pathogenesis of peri-implantitis.In addition,we assessed the potential application of DNA methylation and miRNAs in the prevention,diagnosis,and treatment of peri-implantitis,aiming to provide a foundation for future studies to explore potential therapeutic targets and develop more effective management strategies for this condition.These findings also have broader implications for understanding the pathogenesis of other inflammation-related oral diseases like periodontitis. 展开更多
关键词 Peri-implantitis Epigenetics DNA methylation MicroRNA
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Bioactive expression of eukaryotic cytochrome P450 ferulate-5-hydroxylase in Escherichia coli for sustainable synthesis of antioxidant 5-hydroxyferulic acid 认领 引用
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作者 Ping Sun Yuan Tian +3 位作者 Luyi Wang Pengcheng Chen Dan Wu Pu Zheng 《Bioresources and Bioprocessing》 SCIE EI CSCD 2025年第1期1200-1213,共14页
The eukaryotic cytochrome P450 ferulate-5-hydroxylase(F5H),a membrane-bound protein,plays a critical role in lignin synthesis involved in the biosynthesis of 5-Hydroxyferulic acid(5-HFA)from ferulic acid,with 5-HFA of... The eukaryotic cytochrome P450 ferulate-5-hydroxylase(F5H),a membrane-bound protein,plays a critical role in lignin synthesis involved in the biosynthesis of 5-Hydroxyferulic acid(5-HFA)from ferulic acid,with 5-HFA offering enhanced antioxidant properties.However,there is challenging to engineer recombinants for 5-HFA synthesis by expressing F5H in Escherichia coli.In this work,we co-expressed F5H derived from Arabidopsis thaliana(AtF5H)and NADPH-dependent cytochrome P450 reductase(CPR)in E.coli,and successfully synthesized ortho-hydroxylated ferulic acid.Simultaneously,by modifying the N-terminal regions of membrane proteins,we increased the concentration of product 5-HFA to 63.6 mg/L.Ferulic acid,utilized as the substrate,was extracted from discarded agricultural by-products,demonstrating a sustainable approach to valorizing agricultural waste.This work also advances the application of plant-derived membrane-bound proteins for the production of plant secondary metabolites in E.coli. 展开更多
关键词 Ferulate-5-Hydroxylase Biotransformation 5-Hydroxyferulic acid Ferulic acid N-Terminal modification
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自然灾害评估技术体系 认领 引用
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作者 许冲 黄雨 +11 位作者 孙萍 吴赛儿 张帅 孙纪凯 黄远东 李涛 陈兆宁 邵霄怡 齐文文 何正迎 李垠柯 熊敏 《中国科学基金》 CSSCI CSCD 北大核心 2025年第6期918-929,共12页
在全球复合链生自然灾害风险持续升级与国家治理体系深度转型的背景下,构建具备动态响应与系统集成能力的新一代自然灾害协同评估体系,已成为统筹发展与安全的核心科技任务。现有体系在多灾种耦合建模、动态适应性与数据—决策协同等环... 在全球复合链生自然灾害风险持续升级与国家治理体系深度转型的背景下,构建具备动态响应与系统集成能力的新一代自然灾害协同评估体系,已成为统筹发展与安全的核心科技任务。现有体系在多灾种耦合建模、动态适应性与数据—决策协同等环节存在结构性制约。本文系统梳理了当前灾害评估体系的理论基础、技术路径与制度框架,识别其主要挑战,并提出了以“理论—技术—国家框架”三位一体为主线的系统构建思路。在理论层面,该框架强调重构危险性、暴露度与脆弱性三要素的时变耦合机制,建立涵盖触发、条件改变与级联作用的多灾种交互参数与因果关系库,并构建灾害链演化的动力学模型,揭示复合灾害过程的内在耦合机理,为动态化、定量化风险认知奠定基础。在技术层面,该框架提出构建覆盖“全灾种—全链条—全维度—全过程”的一体化评估体系,发展物理机理与人工智能深度融合的高精度、高效率建模引擎,推动风险表达由等级划分向概率量化范式转型,使风险评估从静态、单灾种向动态、智能化、情景化方向演进。在国家框架层面,研究强调跨部门协同的制度与法治保障,建议建立覆盖全灾种与灾害链的国家级数据库,统一评估方法与指标标准,完善跨灾种法律与治理框架,构建“评估—规划—应急”联动机制,实现评估成果在空间规划、工程布局与应急决策中的有效转化。总体而言,该理论、技术与制度框架为现代自然灾害风险治理提供了系统集成路径。通过实现风险可量化、决策可追溯、治理可评估,推动防灾减灾体系现代化,支撑以韧性为导向的国家安全战略实施与高水平安全能力建设。 展开更多
关键词 自然灾害协同评估体系 复合链生灾害 多灾种耦合建模 动态风险表达 智能化评估 国家安全与治理框架
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Inhibition of KLF7-Targeting Micro RNA 146b Promotes Sciatic Nerve Regeneration 认领 引用 被引量：24
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作者 Wen-Yuan Li Wei-Ting Zhang +7 位作者 Yong-Xia Cheng Yan-Cui Liu Feng-Guo Zhai Ping Sun Hui-Ting Li Ling-Xiao Deng Xiao-Feng Zhu Ying Wang 《Neuroscience Bulletin》 SCIE CAS CSCD 2018年第3期419-437,共19页
A previous study has indicated that Krüppel-like factor 7（KLF7）, a transcription factor that stimulates Schwann cell（SC） proliferation and axonal regeneration after peripheral nerve injury, is a promising the... A previous study has indicated that Krüppel-like factor 7（KLF7）, a transcription factor that stimulates Schwann cell（SC） proliferation and axonal regeneration after peripheral nerve injury, is a promising therapeutic transcription factor in nerve injury. We aimed to identify whether inhibition of micro RNA-146 b（mi R-146 b）affected SC proliferation, migration, and myelinated axon regeneration following sciatic nerve injury by regulating its direct target KLF7. SCs were transfected with mi RNA lentivirus, mi RNA inhibitor lentivirus, or KLF7 si RNA lentivirus in vitro. The expression of mi R146 b and KLF7,as well as SC proliferation and migration, were subsequently evaluated. In vivo, an acellular nerve allograft（ANA） followed by injection of GFP control vector or a lentiviral vector encoding an mi R-146 b inhibitor was used to assess the repair potential in a model of sciatic nerve gap. mi R-146 b directly targeted KLF7 by binding to the 30-UTR, suppressing KLF7. Up-regulation of mi R-146 b and KLF7 knockdown significantly reduced the proliferation and migration of SCs, whereas silencing mi R-146 b resulted in increased proliferation and migration. KLF7 protein was localized in SCs in which mi R-146 b was expressed in vivo.Similarly, 4 weeks after the ANA, anti-mi R-146 b increased KLF7 and its target gene nerve growth factor cascade, promoting axonal outgrowth. Closer analysis revealed improved nerve conduction and sciatic function index score, and enhanced expression of neurofilaments, P0（anti-peripheral myelin）, and myelinated axon regeneration. Our findings provide new insight into the regulation of KLF7 by mi R-146 b during peripheral nerve regeneration and suggest a potential therapeutic strategy for peripheral nerve injury. 展开更多
关键词 miR-146b KLF7 Schwann cells Sciatic nerve injury
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MiR-34a overexpression enhances the inhibitory effect of doxorubicin on HepG2 cells 认领 引用 被引量：10
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作者 Shun-Zhen Zheng Ping Sun +3 位作者 Jian-Ping Wang Yong Liu Wei Gong Jun Liu 《World Journal of Gastroenterology》 SCIE CAS 2019年第22期2752-2762,共11页
BACKGROUND Hepatocellular carcinoma(HCC) is the third leading cause of death from malignant tumors worldwide. More than 50% of HCC cases occur in China. The prognosis remains poor and overall efficacy is still unsatis... BACKGROUND Hepatocellular carcinoma(HCC) is the third leading cause of death from malignant tumors worldwide. More than 50% of HCC cases occur in China. The prognosis remains poor and overall efficacy is still unsatisfactory. Chemotherapy resistance is the most important reason for the poor outcome. Much progress has been made in the study of chemotherapy resistance of HCC;however, the specific mechanisms of progression of HCC have still only been partially established.Therefore, the mechanism of chemotherapy resistance in HCC requires more research.AIM To investigate the effect of miR-34 a expression on the growth inhibition of HepG2 cells by doxorubicin.METHODS A recombinant lentiviral vector containing miR-34 a was constructed and transfected into HepG2 cells. The expression of miR-34 a was detected by reverse transcription-polymerase chain reaction(commonly known as RT-PCR) before and after transfection. Cells were exposed to 2 μM doxorubicin or phosphatebuffered saline before and after transfection. Cell viability in each group was detected by MTT assay, and cell cycle and apoptosis were detected by flow cytometry. Changes in expression levels of phospho(p)-p53, sirtuin(SIRT) 1,cyclin D1, cyclin-dependent kinase(CDK) 4, CDK6, BCL-2, multidrug resistance protein(MDR) 1/P glycoprotein(P-gp), and AXL were detected by Western blotting.RESULTS Recombinant lentiviral vector LV-hsa-mir-34 a was successfully constructed by restriction endonuclease digestion and sequencing. RT-PCR showed that expression of miR-34 a in HepG2 cells was significantly upregulated after transfection(P < 0.01). MTT assay showed that growth of HepG2 cells was inhibited after upregulation of miR-34 a, and viability was significantly decreased after combined treatment with doxorubicin(P < 0.01). Flow cytometry showed that the number of HepG2 cells in G1 phase increased, and G1 phase arrest was more obvious after intervention with doxorubicin(P < 0.01). The apoptosis rate of HepG2 cells was increased after upregulation of miR-34 a, and became more obvious after intervention with doxorubicin(P < 0.01). Western blotting showed that upregulation of miR-34 a combined with treatment with doxorubicin caused significant changes in the expression levels of p-p53, SIRT1, cyclin D1, CDK4,CDK6, BCL-2, MDR1/P-gp and AXL proteins(P < 0.01).CONCLUSION MiR-34 a may enhance the inhibitory effect of doxorubicin by downregulating MDR1/P-gp and AXL, which may be related to p53 expression. 展开更多
关键词 miR-34a Doxorubicin Hepatocellular carcinoma HepG2 cells Growth inhibition
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Dyes adsorption using a synthetic carboxymethyl cellulose-acrylic acid adsorbent 认领 引用 被引量：15
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作者 Genlin Zhang Lijuan Yi +1 位作者 Hui Deng Ping Sun 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2014年第5期1203-1211,共9页
Removal of noxious dyes is gaining public and technological attention. Herein grafting polymerization was employed to produce a novel adsorbent using acrylic acid and carboxymethyl cellulose for dye removal. Scanning ... Removal of noxious dyes is gaining public and technological attention. Herein grafting polymerization was employed to produce a novel adsorbent using acrylic acid and carboxymethyl cellulose for dye removal. Scanning electron microscopy and Fourier-transform infrared spectroscopy verified the adsorbent formed under optimized reaction conditions. The removal ratio of adsorbent to Methyl Orange, Disperse Blue 2BLN and malachite green chloride reached to 84.2%, 79.6% and 99.9%, respectively. The greater agreement between the calculated and experimental results suggested that pseudo second-order kinetic model better represents the kinetic adsorption data. Equilibrium adsorptions of dyes were better explained by the Temkin isotherm. The results implied that this new cellulose-based absorbent had the universaiity for removal of dyes through the chemical adsorption mechanism. 展开更多
关键词 adsorption dye grafting polymerization carboxymethyl cellulose acrylic acid
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Feasibility and safety of sorafenib treatment in hepatocellular carcinoma patients with spontaneous rupture 认领 引用 被引量：10
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作者 Shun-Zhen Zheng De-Jie Liu +4 位作者 Ping Sun Guang-Sheng Yu Yan-Tian Xu Wei Gong Jun Liu 《World Journal of Gastroenterology》 SCIE CAS 2014年第43期16275-16281,共7页
AIM: To report the outcome of patients with ruptured hepatocellular carcinoma (HCC) treated at a single center during a 5-year period.
关键词 Sorafenib Hepatocellular carcinoma Spontaneous rupture Efficacy Safety
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饮食习惯、烟酒使用行为与大学生心理压力的关系 认领 引用 被引量：18
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作者 柳春红 Ping Sun 彭权生 《现代预防医学》 CAS 北大核心 2009年第21期4108-4110,共3页
[目的]了解大学生心理压力状况,揭示饮食、吸烟、饮酒与压力之间的关系。[方法]按横断面调查设计,随机整群抽取广东省一所大学的937名学生,以感觉压力量表和健康行为问卷对所有调查对象进行测试,并采用单因素及多因素分析探讨感觉压力... [目的]了解大学生心理压力状况,揭示饮食、吸烟、饮酒与压力之间的关系。[方法]按横断面调查设计,随机整群抽取广东省一所大学的937名学生,以感觉压力量表和健康行为问卷对所有调查对象进行测试,并采用单因素及多因素分析探讨感觉压力与食物、烟酒之间的相关性。[结果]学生的压力评分均值为21.56±5.12,可乐饮料和西式快餐摄入水平、吸烟和饮酒量与压力正相关,而新鲜蔬菜摄入频率则与压力负相关。[结论]在开展大学生心理压力干预计划时,要采取涉及饮食、吸烟、饮酒等因素的综合预防策略。 展开更多
关键词 心理压力 大学生 饮食 吸烟 饮酒
Nitrogen application regulates antioxidant capacity and flavonoid metabolism,especially quercetin,in grape seedlings under salt stress 认领 引用 被引量：5
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作者 Congcong Zhang Han Wang +13 位作者 Guojie Nai Lei Ma Xu Lu Haokai Yan Meishuang Gong YuanyuanLi Ying Lai Zhihui Pu Li Wei Guiping Chen Ping Sun Baihong Chen Shaoying Ma Sheng Li 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2024年第12期4074-4092,共19页
Salt stress is a typical abiotic stress in plants that causes slow growth,stunting,and reduced yield and fruit quality.Fertilization is necessary to ensure proper crop growth.However,the effect of fertilization on sal... Salt stress is a typical abiotic stress in plants that causes slow growth,stunting,and reduced yield and fruit quality.Fertilization is necessary to ensure proper crop growth.However,the effect of fertilization on salt tolerance in grapevine is unclear.In this study,we investigated the effect of nitrogen fertilizer(0.01 and 0.1 mol L-1NH4NO3)application on the salt(200 mmol L-1NaCl)tolerance of grapevine based on physiological indices,and transcriptomic and metabolomic analyses.The results revealed that 0.01 mol L-1NH4NO3 supplementation significantly reduced the accumulation of superoxide anion(O2-·),enhanced the activities of superoxide dismutase(SOD)and peroxidase(POD),and improved the levels of ascorbic acid(AsA)and glutathione(GSH)in grape leaves compared to salt treatment alone.Specifically,joint transcriptome and metabolome analyses showed that the differentially expressed genes(DEGs)and differentially accumulated metabolites(DAMs)were significantly enriched in the flavonoid biosynthesis pathway(ko00941)and the flavone and flavonol biosynthesis pathway(ko00944).In particular,the relative content of quercetin(C00389)was markedly regulated by salt and nitrogen.Further analysis revealed that exogenous foliar application of quercetin improved the SOD and POD activities,increased the AsA and GSH contents,and reduced the H2O2 and O2-·contents.Meanwhile,10 hub DEGs,which had high Pearson correlations(R2>0.9)with quercetin,were repressed by nitrogen.In conclusion,all the results indicated that moderate nitrogen and quercetin application under salt stress enhanced the antioxidant system defense response,thus providing a new perspective for improving salt tolerance in grapes. 展开更多
关键词 grapevine salt stress nitrogen multi-omics quercetin antioxidant
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The cost of obsessive- compulsive disorder (OCD) in China: a multi- center cross- sectional survey based on hospitals 认领 引用 被引量：12
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作者 Weili Yang Zhen Tang +12 位作者 Xijin Wang Xiancang Ma Yuqi Cheng Bin Wang Ping Sun Wenxin Tang Jia Luo Changhong Wang Ping Li Guiyun Xu Jun Yan Vlasios Brakoulias Zhen Wang 《General Psychiatry》 CSCD 2021年第6期34-41,共8页
Background Obsessive-compulsive disorder(OCD)is considered a very debilitating disorder with severe loss of quality of life and income.Aims This study estimates the quality of life and economic consequences of OCD in ... Background Obsessive-compulsive disorder(OCD)is considered a very debilitating disorder with severe loss of quality of life and income.Aims This study estimates the quality of life and economic consequences of OCD in China.Methods The research team interviewed 639 patients with OCD in 13 hospitals in 12 cities in China.The direct method was used to get the direct cost of OCD.Indirect costs associated with OCD were estimated using the human capital approach.Linear regression analysis was conducted for quality of life and generalised linear model analysis was conducted for total cost.Sensitivity analysis was used to analyse the uncertainty of total cost.Results The mean quality of life score for OCD was 52.78(20.46).The annual total cost of OCD per capita was 24503.78(95%CI:22621.53 to 26386.03)renminbi(RMB)(US$3465.88(95%CI:US$3199.65 to US$3732.11)).The annual cost of OCD in China was estimated to be 37.74 billion(95%CI:34.95 billion to 40.53 billion)RMB(equal to US$5.34 billion(95%CI:US$4.94 billion to US$5.73 billion)).Sensitivity analysis showed that the total annual cost of OCD in China was between 23.15 billion RMB(US$3.27 billion)and 370.00 billion RMB(US$52.33 billion).Worse social function status,more psychiatric symptoms and higher Yale Brown Obsessive-Compulsive Scale(Y-BOCS)score were associated with worse quality of life.The numbers of clinic visits and hospitalisations,socioeconomic status,education,Y-BOCS scores and age were found to be significantly associated with total cost.Conclusions OCD is associated with low quality of life and high costs in China.The findings call for concerted efforts to improve services for patients with OCD.Improvements may include early detection and diagnosis,the provision of evidence-based treatments and relapse prevention strategies. 展开更多
关键词 OCD prevention cost
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Effects of heating rate on the alloy element partitioning and mechanical properties in equiaxedα+βTi-6Al-4V alloy 认领 引用 被引量：6
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作者 Jinhu Zhang Hongtao Ju +8 位作者 Haisheng Xu Liang Yang Zhichao Meng Chen Liu Ping Sun Jianke Qiu Chunguang Bai Dongsheng Xu Rui Yang 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2021年第35期1-9,共9页
The effects of heating rate on the alloy element partitioning and mechanical properties during the phase transformation ofα→βin Ti-6Al-4 V alloy under solution treatment have been investigated by the experiments an... The effects of heating rate on the alloy element partitioning and mechanical properties during the phase transformation ofα→βin Ti-6Al-4 V alloy under solution treatment have been investigated by the experiments and phase field simulations,which reveal the evolutions of microstructure and compositions at the non-equilibrium state and well verify the experimental results.The specific results indicate that the compositions measured through electron probe micro-analysis(EPMA)under a lower heating rate are close to the equilibrium ones corresponding to the solution temperature.Heating up to the target solution temperature,as the heating rate increases,the Al content decreases and V increases in the primaryα(αp)grain with a larger size,the volume fraction ofαpincreases and the composition gradient betweenαpandβphases gets steeper.The interrelated relationship among the diffusion,compositions,solution temperature and free energy of the system has been discussed in detail.Moreover,increasing the heating rate(~20.0 K/min)may help to improve the mechanical properties of the alloy by mainly adjusting theαp/β;volume fractions,αpparticle size and secondaryα(αp)size during the process of heating up to the solution temperature.These results may shed some light on the optimization of the knowledge-based heat treatment route. 展开更多
关键词 Heating rate Alloying element partitioning Microstructure morphology Mechanical properties
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Indole derivatives as agrochemicals:An overview 认领 引用 被引量：5
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作者 Ping Sun Yuanqin Huang +3 位作者 Shunhong Chen Xining Ma Zhaokai Yang Jian Wu 《Chinese Chemical Letters》 SCIE CAS CSCD 2024年第7期66-72,共7页
Indole is a biologically active compound formed by the fusion of benzene and pyrrole,and it is widely found in natural products and drugs.Due to the unique structure and properties of indole,its derivatives often exhi... Indole is a biologically active compound formed by the fusion of benzene and pyrrole,and it is widely found in natural products and drugs.Due to the unique structure and properties of indole,its derivatives often exhibit distinctive physiological activities,which has led to widespread attention in the field of pesticide development.Analyzing the design strategies and structure-activity relationships(SARs)of compounds is a crucial step in developing novel pesticides.This review mainly summarizes indole compounds with plant growth regulating,antiviral,fungicidal,herbicidal,and insecticidal activities,with the aim of providing new insights into the discovery and mechanism of action of novel indole-based pesticides. 展开更多
关键词 Indole compounds Agrochemicals Biological activity Structure-activity relationship Mechanism of action
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Krüppel-like factor 7 attenuates hippocampal neuronal injury after traumatic brain injury 认领 引用 被引量：3
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作者 Wen-Yuan Li Xiu-Mei Fu +6 位作者 Zhen-Dong Wang Zhi-Gang Li Duo Ma Ping Sun Gui-Bo Liu Xiao-Feng Zhu Ying Wang 《Neural Regeneration Research》 SCIE CAS CSCD 2022年第3期661-672,共12页
Our previous study has shown that the transcription factor Krüppel-like factor 7(KLF7) promotes peripheral nerve regeneration and motor function recovery after spinal cord injury.KLF7 also participates in traumat... Our previous study has shown that the transcription factor Krüppel-like factor 7(KLF7) promotes peripheral nerve regeneration and motor function recovery after spinal cord injury.KLF7 also participates in traumatic brain injury,but its regulatory mechanisms remain poorly understood.In the present study,an HT22 cell model of traumatic brain injury was established by stretch injury and oxygenglucose deprivation.These cells were then transfected with an adeno-associated virus carrying KLF7(AAV-KLF7).The results revealed that,after stretch injury and oxygen-glucose deprivation,KLF7 greatly reduced apoptosis,activated caspase-3 and lactate dehydrogenase,downregulated the expression of the apoptotic markers B-cell lymphoma 2(Bcl-2)-associated X protein(Bax) and cleaved caspase-3,and increased the expression of βIII-tubulin and the antiapoptotic marker Bcl-2.Furthermore,KLF7 overexpression upregulated Janus kinase 2(JAK2) and signal transducer and activator of transcription 3(STAT3) phosphorylation in HT22 cells treated by stretch injury and oxygenglucose deprivation.Immunoprecipitation assays revealed that KLF7 directly participated in the phosphorylation of STAT3.In addition,treatment with AG490,a selective inhibitor of JAK2/STAT3,weakened the protective effects of KLF7.A mouse controlled cortical impact model of traumatic brain injury was then established.At 30 minutes before modeling,AAV-KLF7 was injected into the ipsilateral lateral ventricle.The protein and m RNA levels of KLF7 in the hippocampus were increased at 1 day after injury and recovered to normal levels at 3 days after injury.KLF7 reduced ipsilateral hippocampal atrophy,decreased the injured cortex volume,downregulated Bax and cleaved caspase-3 expression,and increased the number of 5-bromo-2'-deoxyuridine-positive neurons and Bcl-2 protein expression.Moreover,KLF7 transfection greatly enhanced the phosphorylation of JAK2 and STAT3 in the ipsilateral hippocampus.These results suggest that KLF7 may protect hippocampal neurons after traumatic brain injury through activation of the JAK2/STAT3 signaling pathway.The study was approved by the Institutional Review Board of Mudanjiang Medical University,China(approval No.mdjyxy-2018-0012) on March 6,2018. 展开更多
关键词 apoptosis hippocampus JAK2/STAT3 Kruppel-like factor 7 neuroprotection oxygen-glucose deprivation stretch traumatic brain injury
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Black tantalic oxide submicro-particles coating on PEEK fibers woven into fabrics as artificial ligaments with photothermal antibacterial effect and osteogenic activity for promoting ligament-bone healing 认领 引用 被引量：4
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作者 Fan Wang Mengyao Wang +6 位作者 Qingsong He Xuehong Wang Ping Sun Yinjun Ji Yunfei Niu Fengqian Li Jie Wei 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2023年第2期195-208,共14页
Design of artificial ligaments possessing both osteogenic activity and antibacterial effect that promotes ligament-bone healing and prevents bacterial infection in bone tunnels for anterior cruciate ligament(ACL)recon... Design of artificial ligaments possessing both osteogenic activity and antibacterial effect that promotes ligament-bone healing and prevents bacterial infection in bone tunnels for anterior cruciate ligament(ACL)reconstruction remains a significant challenge.In this study,black tantalic oxide(BTO)submicro-particles with oxygen vacancies and structure defects were fabricated by using traditional white tan-talic oxide(WTO)through magnesium thermal reduction(MTR)method,and BTO was coated on polyetheretherketone(PEEK)fibers(PKF),which were woven into fabrics(PBT)as artificial ligaments.PBT with BTO coating exhibited excellent photothermal performance,which possessed not only antibac-terial effects in vitro but also anti-infective ability in vivo.PBT with optimized surface properties(e.g.,submicro-topography and hydrophilicity)not only significantly facilitated rat bone mesenchymal stem cells(BMSC)responses(e.g.,proliferation and osteogenic differentiation)in vitro but also stimulated new bone formation for ligament-bone healing in vivo.The presence of oxygen vacancies and structure de-fects in BTO did not change the surface properties and osteogenic activity of BPT while displaying an outstanding photothermal antibacterial effect.In summary,BPT with osteogenic activity and photother-mal antibacterial effect promoted bone regeneration and prevented bacterial infection,thereby promoting ligament-bone healing.Therefore,PBT would have tremendous potential as a novel artificial ligament for ACL reconstruction. 展开更多
关键词 Black tantalic oxide PEEK fibers Artificial ligament Photothermal antibacterial effects Ligament-bone healing
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Characteristics of Chinese Families in Which Children and Both Parents Are Diagnosed with Malignant Tumors:A Retrospective Study 认领 引用 被引量：3
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作者 Ju Liu Zhijian Xu +2 位作者 Xiaofeng Bi Ping Sun Jiaqin Huang 《Chinese Medical Sciences Journal》 CAS CSCD 2021年第1期27-34,共8页
Objective To characterize Chinese families in which both parents and at least one child are diagnosed with malignant diseases and provide reference for cancer screening or early detection in people whose both parents ... Objective To characterize Chinese families in which both parents and at least one child are diagnosed with malignant diseases and provide reference for cancer screening or early detection in people whose both parents are diagnosed with cancer.Methods Medical records of all clients to the center of cancer screening and prevention of the National Cancer Center/Cancer Hospital between January 2008 and February 2018 were screened to select families in which both parents and at least one child were diagnosed with malignant diseases.The cancer profiles of fathers,mothers,sons and daughters,their age distribution at diagnosis,and similarity of cancers between two generations were analyzed.The proportions of each cancer in males and females of the cohort were compared with corresponding data from the National Cancer Center Registry of China(NCCRC)in 2013.Results Totally 13S families were identified from records of 33200 clients.Proportion of lung cancer in fathers(40/135,29.6%)and in mothers(38/135,28.1%)were higher than the national data(23.9%in males and 14.9%in females,respectively).The proportion of breast cancer in daughters(35/109,32.1%)was higher than that of mothers(14/135,10.4%)and the national data(17.1%),In 71 father-son pairs of cancer,46.5%(33/71)were of the same systematic disease,and 16.9%(12/71)were of the same cancer.These two indexes were 31.2%(n=34)and 10.1%(n=l 1),respectively in the 109 father-daughter pairs of cancer,36.6%(n=26)and 8.5%(n=6)respectively in the 71 mother-son pairs of cancer,and 31.2%(n=34)and 20.2%(n=20)respectively in the 109 mother-daughter pairs of cancer.Sons were more likely to suffer from cancers originated from the same system as father s cancer than daughters(χ2=4.299,P<0.05),and daughters were more likely to suffer from the same cancer as their mother's cancer than sons(χ2=4.506,P<0.05).The age(mean±standard deviation)of the daughters(52.4±12.7)and the sons(59.4±10.9)at diagnosis were significantly younger than the fathers(65.5±12.2)and the mothers(65.7±12.5)(all P<0.001)・Conclusions For people whose both parents are diagnosed as cancer,screening or early detection examinations should cover a full range of cancers rather than the cancers their father and mother have suffered,or cancers stemmed from the same system as their parents cancers.We suggest screening or early detection program for these special population start earlier than that for the general population,with emphasis on cancers derived from digestive system for males and women-specific cancers,i.e.,breast cancer,ovarian cancer,cervical cancer and uterine cancer for females. 展开更多
关键词 family history parents daughter son early detection malignant tumor
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Cuproptosis-related lncRNA JPX regulates malignant cell behavior and epithelial-immune interaction in head and neck squamous cell carcinoma via miR-193b-3p/PLAU axis 认领 引用 被引量：3
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作者 Mouyuan Sun Ning Zhan +14 位作者 Zhan Yang Xiaoting Zhang Jingyu Zhang Lianjie Peng Yaxian Luo Lining Lin Yiting Lou Dongqi You Tao Qiu Zhichao Liu Qianting Wang Yu Liu Ping Sun Mengfei Yu Huiming Wang 《International Journal of Oral Science》 SCIE CAS CSCD 2024年第4期743-758,共16页
The development,progression,and curative efficacy of head and neck squamous cell carcinoma(HNSCC)are influenced by complex interactions between epithelial and immune cells.Nevertheless,the specific changes in the natu... The development,progression,and curative efficacy of head and neck squamous cell carcinoma(HNSCC)are influenced by complex interactions between epithelial and immune cells.Nevertheless,the specific changes in the nature of these interactions and their underlying molecular mechanisms in HNSCC are not yet fully understood.Cuproptosis,a form of programmed cell death that is dependent on copper,has been implicated in cancer pathogenesis.However,the understanding of cuproptosis in the context of HNSCC remains limited.In this study,we have discovered that cuproptosis-related long noncoding RNAs(CRLs)known as JPX play a role in promoting the expression of the oncogene urokinase-type plasminogen activator(PLAU)by competitively binding to miR-193b-3p in HNSCC.The increased activity of the JPX/miR-193b-3p/PLAU axis in malignant epithelial cells leads to enhanced cell proliferation,migration,and invasion in HNSCC.Moreover,the overexpression of PLAU in tumor epithelial cells facilitates its interaction with the receptor PLAUR,predominantly expressed on macrophages,thereby influencing the abnormal epithelial–immune interactome in HNSCC.Notably,the JPX inhibitor Axitinib and the PLAU inhibitor Palbociclib may not only exert their effects on the JPX/miR-193b-3p/PLAU axis that impacts the malignant tumor behaviors and the epithelial–immune cell interactions but also exhibit synergistic effects in terms of suppressing tumor cell growth and arresting cell cycle by targeting epidermal growth factor receptor(EGFR)and cyclin-dependent kinase(CDK4/6)for the treatment of HNSCC. 展开更多
关键词 malignant squamous invasion
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