Understanding the complex deformation mechanisms of non-equimolar multi-principal element alloys(MPEAs)requires high-fidelity atomic-scale simulations.This study develops a deep potential(DP)model to enable molecular ...Understanding the complex deformation mechanisms of non-equimolar multi-principal element alloys(MPEAs)requires high-fidelity atomic-scale simulations.This study develops a deep potential(DP)model to enable molecular dynamics simulations of the Ta0.4Ti2Zr(Ta0.4)alloy.Monte Carlo simulations using this potential reveal Ta atom precipitation in the Ta0.4alloy.Under uniaxial tensile loading along the[100]direction in the NPT ensemble,the alloy undergoes a remarkable sequence of phase transformations:an initial body-centered cubic(BCC1)to face-centered cubic(FCC)transformation,followed by a reverse transformation from FCC to a distinct BCC phase(BCC2),and finally a BCC2 to hexagonal close-packed(HCP)transformation.Critically,the reverse FCC to BCC2 transformation induces significant volume contraction.We demonstrate that the inversely transformed BCC2 phase primarily accommodates compressive stress.Concurrently,the reorientation of BCC2 crystals contributes substantially to the observed high strain hardening.These simulations provide atomic-scale insights into the dynamic structural evolution,sequential phase transformations,and stress partitioning during deformation of the Ta0.4alloy.The developed DP model and the revealed mechanisms offer fundamental theoretical guidance for accelerating the design of high-performance MPEAs.展开更多
Blast injury is a leading cause of military casualties,and the thorax,which houses the lungs and heart,is particularly vulnerable to blast waves.While previous studies have primarily examined anterior ex-posures,the m...Blast injury is a leading cause of military casualties,and the thorax,which houses the lungs and heart,is particularly vulnerable to blast waves.While previous studies have primarily examined anterior ex-posures,the mechanisms of thoracic response and organ injury under multi-directional blasts remain poorly understood.In this study,a validated human finite element model was employed to investigate the effects of blast wave incident direction on thoracic injury.Results indicate that interaction between blast and the thorax consistently involves reflection,diffraction,and convergence,with pressures on the loaded side dominating the overall response.Strong direction-dependent effects were observed in pressure transmission and energy distribution:under anterior loading,the heart experienced pressure amplitudes 4.2 times higher than the lungs due to density contrasts;under posterior loading,organ energy absorption decreased to 5.39%owing to chest wall constraints;and under lateral loading,impedance mismatch of the heart attenuated contralateral lung pressures by more than 90%.Lung in-juries were concentrated in the inferior lobes due to weak constraints of the lower thoracic cage,while asymmetry between left and right lung damage was attributed to organ arrangement and cage defor-mation.These findings elucidate the directional dependence of thoracic blast injury mechanisms,of-fering new insights for injury assessment and the design of protective equipment.展开更多
High-entropy alloys(HEAs)have attracted considerable interest from researchers owing to their tunable chemical compositions,exceptional structural stability,and promising catalytic properties.However,their large-scale...High-entropy alloys(HEAs)have attracted considerable interest from researchers owing to their tunable chemical compositions,exceptional structural stability,and promising catalytic properties.However,their large-scale application is often hindered by complex manufacturing techniques and poor durability.Herein,we report a simple and cost-effective threedimensional(3D)printing strategy to fabricate a 3D-FeMnCrCo HEA catalyst with precisely controlled composition,structure,and porosity.The as-prepared 3D-FeMnCrCo catalyst exhibits high printing accuracy,excellent compression resistance,and remarkable efficiency in degrading organic contaminants using peroxymonosulfate(PMS)activation.Notably,the catalyst maintains outstanding catalytic stability over 100 consecutive cycles,which outperforms most of its powdered counterparts.Theoretical calculations and controlled experiments reveal that a synergistic combination of Fe/Mn electron donation,Comediated charge buffering,and Cr-driven orbital hybridization lowers the electron transfer energy barrier,thereby enhancing PMS activation.Mechanistic studies further show that singlet oxygen is the predominant reactive species in the 3DFeMnCrCo/PMS system.The biotoxicity of degraded pollutants and the catalyst's performance in treating actual wastewater are also systematically evaluated.This work provides critical insights into the practical application of HEAs in water treatment and guides the design of efficient,stable,and easily recoverable catalysts for environmental remediation.展开更多
As a high-energy-density primary battery,the Li-SOCl2 battery offers significant advantages over other primary systems,including a high operating voltage,wide temperature tolerance,and low self-discharge rate.Howev...As a high-energy-density primary battery,the Li-SOCl2 battery offers significant advantages over other primary systems,including a high operating voltage,wide temperature tolerance,and low self-discharge rate.However,owing to the irreversible electrochemical reaction mechanism,despite its energy density of up to 700 Wh kg-1 at the cell level,this battery system has remained confined to the category of primary batteries,thereby limiting its use in cyclic applications.Recent advances in electrochemical technologies have enabled the reversible redox chemistry of Li-SOCl2 batteries,transforming them into rechargeable systems.This article provides a systematic overview of the technical evolution,reaction mechanisms,safety constraints,engineering countermeasures,and electrochemical performance enhancement of Li-SOCl2 primary batteries since their introduction.First,the modification methods for the lithium anode,carbon cathode,electrolyte,and electrocatalyst in Li-SOCl2 primary batteries are discussed,along with their mechanisms for improving electrochemical performance.We then review the SOCl2-based rechargeable Li metal batteries(LMBs)that evolved from the Li-SOCl2 primary batteries.With their higher energy density,these systems have become promising candidates to replace traditional Li-ion batteries(LIBs).This review focuses on the construction of key components,such as the positive electrode carrier,novel alloy anode,and electrolyte,as well as their impact on electrochemical performance in rechargeable batteries.Finally,we summarize current research progress and propose future directions for SOCl2-based LMBs aimed at enhancing overall electrochemical performance.These insights provide a theoretical foundation for the development of next-generation high-energy-density energy-storage technologies.展开更多
Energetic multi-principal-element alloys(EMPEAs)have garnered considerable attention for their reactive characteristics and compositional flexibility in pyrotechnic applications.However,the complex fragmentation behav...Energetic multi-principal-element alloys(EMPEAs)have garnered considerable attention for their reactive characteristics and compositional flexibility in pyrotechnic applications.However,the complex fragmentation behavior under impact loading presents challenges for optimal design.This study established a machine learning framework to predict the mean particle size(MPS)of EMPEAs under ballistic impact conditions and achieve end-to-end material design.Using ballistic gun experiment data from 110 EMPEA samples,multi-stage feature dimensionality reduction through Pearson correlation analysis and genetic algorithm identified five key predictors from 28 initial material descriptors.Among six evaluated algorithms,the AdaBoost model demonstrated optimal performance(R2=0.851).Model interpretability analysis revealed that atomic radius mismatch(ΔR),mixing entropy(ΔSmix),thermodynamic parameter(ATE),bulk modulus mismatch(ΔK),and impact velocity(v),all exhibit negative correlations with MPS,withΔR identified as the most critical factor.Symbolic regression confirmedΔR's exponential negative relationship with MPS.Ti15Zr50Ta35 EMPEA was designed and experimentally validated,achieving a quasi-static overpressure of 0.22 MPa at 1300 m/s impact velocity with sizedependent oxidation behavior in fragments,outperforming most existing energetic structural alloys.This work demonstrates the effectiveness of machine learning in understanding impact fragmentation mechanisms and facilitating the design of high-performance EMPEAs with enhanced energy release characteristics.展开更多
Metal organic framework(MOF) shows great potential in the research field of photocatalysis,and it is a big challenge to achieve efficient photocatalytic activity.In this work,we have successfully grown two-dimensional...Metal organic framework(MOF) shows great potential in the research field of photocatalysis,and it is a big challenge to achieve efficient photocatalytic activity.In this work,we have successfully grown two-dimensional MOF(2D-MOF) nanosheets on 2D-MOF nanosheets for the first time using a homometallic nodal strategy,and successfully prepared ultrathin nanosheets with tightly bound 2D/2D heterojunctions.2D Ni-BDC nanosheets were used as carriers to grow 2D Ni-TCPP nanosheets on top of them.Ni-TCPP has a high light absorption capacity,thus extending the light absorption range of 2D/2D heterojunctions.The tight coupling of the heterojunction effectively shortens the electron transfer distance,promotes the separation of interracial charges,and improves the photocatalytic activity.Particularly,Ni-BDC/Ni-TCPP-3can achieve to a hydrogen production rate of428.0 μmol·g-1,approximately 5.75 times higher than NiBDC and 5.24 times higher than Ni-TCPP,respectively.Thus,2D-MOF/2D-MOF heterojunctions provide a promising strategy for enhancing photocatalytic performance through rational heterostructure design with homometallic node strategy.展开更多
Highly integrated micro-nano electronic devices suffer from severe heat dissipation challenges,and flow cooling in nanochannels is an effective solution.During convective heat transfer at liquid-solid interfaces,surfa...Highly integrated micro-nano electronic devices suffer from severe heat dissipation challenges,and flow cooling in nanochannels is an effective solution.During convective heat transfer at liquid-solid interfaces,surface wettability and rough morphology are key parameters governing thermal transport;however,their combined effects remain unclear.In this study,molecular dynamics simulations are utilized to examine the synergistic effects of surface wettability and nanopillar arrays on thermal transport and fluid dynamics within nanochannels.The results show that increasing surface hydrophilicity and roughness reduces the thermal slip length and increases the Nusselt number,thereby enhancing heat transfer performance in the nanochannel.From a fluid dynamics standpoint,velocity slip length decreases while the relative friction coefficient increases,signifying greater flow resistance.For the present model,the enhancement in heat transfer induced by increased wettability is significantly greater than that caused by increased roughness,whereas their effects on flow resistance are difficult to distinguish the dominance.At the microscale,increased wettability and roughness facilitate the accumulation of fluid atoms near the liquid-solid interface.The elevated interaction energy between solid platinum atoms and fluid argon atoms is identified as the primary mechanism underlying thermal transport enhancement in nanochannels.This investigation offers valuable insights for the optimized thermal management of micro-nano electronic devices.展开更多
This study proposes an LLM-empowered edge-cloud digital twin architecture for intelligent FM.Edge servers acquire and pre-process sensor data,with Flask-based cloud middleware aggregating into hybrid data storage.The ...This study proposes an LLM-empowered edge-cloud digital twin architecture for intelligent FM.Edge servers acquire and pre-process sensor data,with Flask-based cloud middleware aggregating into hybrid data storage.The LLM performs semantic reasoning to generate operational decisions,relaying insights in real time to a Unity-engineered 3D visualization environment.BIM semantic parsing segregates geometric from non-graphical attributes,integrating multi-source data at room-floor granularity to establish a“perception-analysis-decision-execution”closed loop,thereby enhancing situational awareness and decision support for facility managers.展开更多
In order to understand the influence of ordering behaviors on the thermodynamic and mechanical properties of multi-principal element alloys(MPEAs),the temperature-dependent thermodynamic properties and mechanical prop...In order to understand the influence of ordering behaviors on the thermodynamic and mechanical properties of multi-principal element alloys(MPEAs),the temperature-dependent thermodynamic properties and mechanical properties of FCC_CoNiV MPEAs were comparatively predicted,where the alloys were modeled as the ordered configurations based on our previously predicted site occupying fractions(SOFs),as well as disordered configuration based on traditional special quasi-random structure(SQS).The ordering behavior not only improves the thermodynamic stability of the structure,but also increases the elastic properties and Vickers hardness.For example,at 973 K,the predicted bulk modulus(B),shear modulus(G),Young’s modulus(E),and Vickers hardness(HV)of FCC_CoNiV MPEA based on SOFs configuration are 187.82,79.03,207.93,and 7.58 GPa,respectively,while the corresponded data are 172.58,57.45,155.14,and 4.64 GPa for the SQS configuration,respectively.The Vickers hardness predicted based on SOFs agrees considerably well with the available experimental data,while it is underestimated obviously based on SQS.展开更多
Menopause is characterized by the cessation of menstruation and a decline in reproductive function,which is an intrinsic component of the aging process.However,it has been a frequently overlooked field of women’s hea...Menopause is characterized by the cessation of menstruation and a decline in reproductive function,which is an intrinsic component of the aging process.However,it has been a frequently overlooked field of women’s health.The oral and gut microbiota,constituting the largest ecosystem within the human body,are important for maintaining human health and notably contribute to the healthy aging of menopausal women.Therefore,a comprehensive review elucidating the impact of the gut and oral microbiota on menopause for healthy aging is of paramount importance.This paper presents the current understanding of the microbiome during menopause,with a particular focus on alterations in the oral and gut microbiota.Our study elucidates the complex interplay between the microbiome and sex hormone levels,explores microbial crosstalk dynamics,and investigates the associations between the microbiome and diseases linked to menopause.Additionally,this review explores the potential of microbiome-targeting therapies for managing menopause-related diseases.Given that menopause can last for approximately 30 years,gaining insights into how the microbiome and menopause interact could pave the way for innovative interventions,which may result in symptomatic relief from menopause and an increase in quality of life in women.展开更多
The complex ceramic core used for hollow turbine blades requires a high porosity and a high fiexural strength. For a better balance between porosity and fiexural strength, ceramic materials with porous structures are ...The complex ceramic core used for hollow turbine blades requires a high porosity and a high fiexural strength. For a better balance between porosity and fiexural strength, ceramic materials with porous structures are preferred. In order to achieve the transition from disordered pore formation to ordered pore formation, Al2O3 ceramic cores with triply periodic minimal surface(TPMS) micro lattice structures with different structural configurations(gyroid, diamond, and neovius) and different volume fractions of lattice structures(30, 40, and 50, vol.%) were designed and prepared by vat photopolymerization 3D printing. The effects of structural configuration and volume fraction of the lattice structure on the following structural shrinkage, microstructure, and flexural strength were investigated. The shrinkage relationship of the three lattice configurations is: neovius>diamond>gyroid. Besides, it is found that with an increase in the volume fraction of the 3D printed Al2O3 ceramic micro lattice structures, their fiexural strength correspondingly increases ranging from 54.95 MPa to 139.1 MPa. The maximum average fiexural strength of the 3D printed Al2O3 ceramic micro lattice structures is obtained when the structural configuration is diamond and with a volume fraction of 50vol.%, which is 139.1 MPa. Even when the volume fraction of the lattice structure is 30vol.%, that is to say the porosity is 70%, the fiexural strength is as high as 50-70 MPa, which can still be maintained at a high level. In addition, when the volume fraction of the lattice structure is a certain value, the sample with diamond configuration has a higher strength. The internal pore morphology, pore size, and porosity of the cores are precisely controlled, achieving both a high porosity and a high strength. Therefore, this study maintains high porosity and high strength simultaneously, providing a new lattice structure design idea for 3D printed ceramic cores.展开更多
The growing severity of environmental challenges has accelerated advancements in renewable energy technologies,highlighting the critical need for efficient energy storage solutions.Rechargeable batteries,as primary sh...The growing severity of environmental challenges has accelerated advancements in renewable energy technologies,highlighting the critical need for efficient energy storage solutions.Rechargeable batteries,as primary short-term energy storage devices,have seen significant progress.Among emerging optimization strategies,high-entropy electrolytes have garnered attention for their superior ionic conductivity and ability to broaden batteries’operational temperature ranges.Rooted in the thermodynamic concept of entropy,high-entropy materials,originally exemplified by high-entropy alloys,have demonstrated enhanced structural stability and advanced electrochemical performance through the synergistic integration of multiple components.High-entropy liquid electrolytes,both aqueous and non-aqueous,offer unique opportunities for entropy manipulation due to their inherently disordered structures.However,their complex compositions present challenges,as minor changes in formulation can lead to significant performance variations.This review introduces the fundamentals of entropy tuning,surveys recent advances in high-entropy liquid electrolytes,and analyzes the interplay between entropy and electrochemical behavior.Finally,it discusses design strategies and future perspectives for the practical implementation of high-entropy liquid electrolytes in next-generation energy storage systems.展开更多
Considering the growing pre-lithiation demand for high-performance Si-based anodes and consequent additional costs caused by the strict pre-lithiation environment,developing effective and environmentally stable pre-li...Considering the growing pre-lithiation demand for high-performance Si-based anodes and consequent additional costs caused by the strict pre-lithiation environment,developing effective and environmentally stable pre-lithiation additives is a challenging research hotspot.Herein,interfacial engineered multifunctional Li13Si4@perfluoropolyether(PFPE)/LiF microanoparticles are proposed as anode pre-lithiation additives,successfully constructed with the hybrid interface on the surface of Li13Si4through PFPE-induced nucleophilic substitution.The synthesized multifunctional Li13Si4@PFPE/LiF realizes the integration of active Li compensation,long-term chemical structural stability in air,and solid electrolyte interface(SEI)optimization.In particular,the Li13Si4@PFPE/LiF with a high pre-lithiation capacity(1102.4 mAh g-1)is employed in the pre-lithiation Si-based anode,which exhibits a superior initial Coulombic efficiency of 102.6%.Additionally,in situ X-ray diffraction/Raman,density functional theory calculation,and finite element analysis jointly illustrate that PFPE-predominant hybrid interface with modulated abundant highly electronegative F atoms distribution reduces the water adsorption energy and oxidation kinetics of Li13Si4@PFPE/LiF,which delivers a high pre-lithiation capacity retention of 84.39%after exposure to extremely moist air(60%relative humidity).Intriguingly,a LiF-rich mechanically stable bilayer SEI is constructed on anodes through a pre-lithiation-driven regulation for the behavior of electrolyte decomposition.Benefitting from pre-lithiation via multifunctional Li13Si4@PFPE/LiF,the full cell and pouch cell assembled with pre-lithiated anodes operate with long-time stability of 86.5%capacity retention over 200 cycles and superior energy density of 549.9 Wh kg-1,respectively.The universal multifunctional pre-lithiation additives provide enlightenment on promoting large-scale applications of pre-lithiation on commercial high-energy-density and long-cycle-life lithium-ion batteries.展开更多
Formaldehyde(HCHO)is a high-yield product of the oxidation of volatile organic compounds(VOCs)released by anthropogenic activities,fires,and vegetations.Hence,we examined the spatiotemporal variation trends in HCHO co...Formaldehyde(HCHO)is a high-yield product of the oxidation of volatile organic compounds(VOCs)released by anthropogenic activities,fires,and vegetations.Hence,we examined the spatiotemporal variation trends in HCHO columns observed using the Ozone Monitoring Instrument(OMI)during 2005–2021 across the Fenwei Plain(FWP)and analysed the source and variability of HCHO using multi-source data,such as thermal anomalies.The spatial distribution of the annualmean HCHO in the FWP increased from northwest to southeast during 2005–2021,and the high-value aggregation areas contracted and gradually clustered,forming a belt-shaped distribution area from Xi’an to Baoji,north of the Qinling Mountains.The annual mean HCHO concentration generally showed a two-step increase over the 17 years.Fires showed a single-peak trend in March and a double-peak M-shaped trend in March and October,whereas urban thermal anomalies(UTAs)showed an inverted U-shaped trend over 17 years,with peaks occurring in May.The HCHO peaks are mainly caused by the alternating contributions of fires and UTAs.The fires and UTAs(predominantly industrial heat sources)played a role in controlling the background level of HCHO in the FWP.Precipitation and temperature were also important influencing variables for seasonal variations,and the influence of plant sources on HCHO concentrations had significant regional characteristics and contributions.In addition,the FWP has poor dispersion conditions and is an aggregated area for the long-range transport of air pollutants.展开更多
In recent years,subtitling has emerged as a prominent topic in the field of translation studies.This paper conducts a quantitative analysis of literature related to“subtitling”retrieved from the China National Knowl...In recent years,subtitling has emerged as a prominent topic in the field of translation studies.This paper conducts a quantitative analysis of literature related to“subtitling”retrieved from the China National Knowledge Infrastructure(CNKI),focusing on sources indexed in the CSSCI and Peking University Core Journals databases.Utilizing the bibliometric tool CiteSpace,the study reviews the research hotspots and developmental trends in Chinese subtitling studies over the past two decades.The findings reveal that,driven by the growth of the film and television industry,deepening cross-cultural communication,and continuous technological advancements,research in this field has gradually shifted from theoretical exploration to practical application.The focus has become increasingly refined,diversified,and intelligent,expanding into interdisciplinary and multimodal translation studies.The paper also discusses current limitations in the research and outlines future directions,offering targeted suggestions to provide valuable references for further studies and practical endeavors in this domain.展开更多
Rosmarinic acid(RA) can elicit a neuroprotective effect against ischemic stroke, but the precise molecular mechanism remains poorly understood. In this study, an experimental ischemic stroke model was established in...Rosmarinic acid(RA) can elicit a neuroprotective effect against ischemic stroke, but the precise molecular mechanism remains poorly understood. In this study, an experimental ischemic stroke model was established in CD-1 mice(Beijing Vital River Laboratory Animal Technology, Beijing, China) by occluding the right middle cerebral artery for 1 hour and allowing reperfusion for 24 hours. After intraperitoneally injecting model mice with 10, 20, or 40 mg/kg RA, functional neurological deficits were evaluated using modified Longa scores. Subsequently, cerebral infarct volume was measured using TTC staining and ischemic brain tissue was examined for cell apoptosis with TUNEL staining. Superoxide dismutase activity and malondialdehyde levels were measured by spectrophometry. Expression of heme oxygenase-1(HO-1), nuclear factor erythroid 2-related factor 2(Nrf2), Bcl-2, Bax, Akt, and phospho-Ser473 Akt proteins in ischemic brain tissue was detected by western blot, while mRNA levels of Nrf2, HO-1, Bcl-2, and Bax were analyzed using real time quantitative PCR. In addition, HO-1 enzyme activity was measured spectrophotometrically. RA(20 and 40 mg/kg) greatly improved neurological function, reduced infarct volume, decreased cell apoptosis, upregulated Bcl-2 protein and mRNA expression, downregulated Bax protein and mRNA expression, increased HO-1 and Nrf2 protein and mRNA expression, increased superoxide dismutase activity, and decreased malondialdehyde levels in ischemic brain tissue of model mice. However, intraperitoneal injection of a HO-1 inhibitor(10 mg/kg zinc protoporphyrin IX) reversed the neuroprotective effects of RA on HO-1 enzyme activity and Bcl-2 and Bax protein expression. The PI3 K/Akt signaling pathway inhibitor LY294002(10 mM) inhibited Akt phosphorylation, as well as Nrf2 and HO-1 expression. Our findings suggest that RA has anti-oxidative and anti-apoptotic properties that protect against ischemic stroke by a mechanism involving upregulation of Nrf2 and HO-1 expression via the PI3 K/Akt signaling pathway.展开更多
There are widespread Mesozoic–Cenozoic terrestrial volcanic activities in East China,and they produced favorable geologic factors for the volcanic reservoirs.To reveal the spatio-temporal evolution of regional volcan...There are widespread Mesozoic–Cenozoic terrestrial volcanic activities in East China,and they produced favorable geologic factors for the volcanic reservoirs.To reveal the spatio-temporal evolution of regional volcanisms and their tectonic setting,we subdivide Mesozoic–Cenozoic volcanic activities into 6 volcanic cycles(Ⅰ–Ⅵ),and summarize the temporal-spatial distribution,rock association and tectonic setting of each cycle.The Cycle I forms a post-orogenic intraplate bimodal volcanic association.The cyclesⅡandⅢinclude arc volcanic associations formed in compressional and extensional subduction environments,respectively.The CycleⅣcontains a post-orogenic arc bimodal association.The CycleⅤis a basaltic association of tholeiite series under initial rift setting,and the CycleⅥis basaltic association of alkaline series under typical rift setting.The volcanic strata between each cycle are bounded by regional unconformity.The above 6 volcanic cycles correspond to 6 sequential stages of tectonic evolutions from the Early Jurassic post-orogeny,the Mid-Jurassic–Cretaceous subduction of the paleo-Pacific Plate to the Cenozoic marginal rifting.According to the geological characteristics of volcanic reservoirs in different volcanic cycles,it is put forward that the CycleⅤis the major formation period of volcanic reservoirs in East China and should be the focus of exploration,and that the volcanic reservoirs of the CycleⅣare also worthy of attention.展开更多
The present study was designed to elucidate whether the mechanism by which osthole decreases collagenⅠ/III contents and their ratio is regulating the TGF-β/Smad signaling pathway in TGF-β1-overexpressed mouse cardi...The present study was designed to elucidate whether the mechanism by which osthole decreases collagenⅠ/III contents and their ratio is regulating the TGF-β/Smad signaling pathway in TGF-β1-overexpressed mouse cardiac fibroblasts(CFs). These CFs were cultured and treated with different concentrations of osthole. Our results showed that the TGF-β1 expression in the CFs transfected with that the recombinant expression plasmids pc DNA3.1(+)-TGF-β1 was significantly enhanced. After the CFs were treated with 1.25-5 μg·m L-1 of osthole for 24 h, the m RNA and protein expression levels of collagensⅠand III were reduced. The collagen Ⅰ/III ratio was also reduced. The m RNA and protein expression levels of TGF-β1, TβRⅠ, Smad2/3, P-Smad2/3, Smad4, and α-SMA were decreased, whereas the expression level of Smad7 was increased. These effects suggested that osthole could inhibit collagen Ⅰ and III expression and reduce their ratio via the TGF-β/Smad signaling pathway in TGF-β1 overexpressed CFs. These effects of osthole may play beneficial roles in the prevention and treatment of myocardial fibrosis.展开更多
In this study,the dynamic compressive response behavior of a body-centered cubic(BCC)single-phase TiZrNbV refractory high-entropy alloy(RHEA)was investigated under impact at speeds of 313-1584 m s-1using two-stage,...In this study,the dynamic compressive response behavior of a body-centered cubic(BCC)single-phase TiZrNbV refractory high-entropy alloy(RHEA)was investigated under impact at speeds of 313-1584 m s-1using two-stage,gas-gun-driven,high-speed plate-impact experiments;recovery sample analysis;and theoretical calculations.The strain rate and pressure were approximately 107 s−1 and 5.07-29.37 GPa,respectively.The results showed that the TiZrNbV RHEA had a Hugoniot elastic limit of 4.12-5.86 GPa and a spall strength of 1.84-2.03 GPa.The initial yield strength of the alloy showed a strong strain-rate dependence and could be described by the modified Zerilli-Armstrong model,while the phonon-damping effect was the main reason for its high strain-rate sensitivity.Microstructural analysis showed that the dynamic deformation of the TiZrNbV RHEA was controlled by the dislocation slip,dislocation proliferation,intersection of the deformation bands,and grain refinement.The analysis also showed that the intergranular,transgranular,and mixed-type cracks dominated the spall failure of the material.The dynamic Hall-Petch effect and pinning from the lattice distortion led to high dynamic yield strength.The critical strain rate for the phonon drag effect was positively related to the relative atomic mass and local strain field of the metals.Within the experimental loading range,the RHEA showed good structural stability,and simultaneously,the theoretical calculation method for the equation of state based on a cold-energy mixture could accurately predict its shock-response behavior.The valence-electron concentration(VEC)had a direct effect on the shock-compression properties of the HEAs;higher VEC implied more difficulty in compressing the HEAs.The findings of this study provide insights into understanding the mechanical response characteristics of RHEAs under extreme conditions such as high-speed impact and ultrahigh strain-rate loading.展开更多
Objective To evaluate the effects of environmental factors and microRNAs (miRNAs) (miR-126, miR-143, and miR-145) on the risk of coronary heart disease (CHD). Methods A frequency-matched case-control study (450...Objective To evaluate the effects of environmental factors and microRNAs (miRNAs) (miR-126, miR-143, and miR-145) on the risk of coronary heart disease (CHD). Methods A frequency-matched case-control study (450 patients, 450 controls) was conducted from April 2014 to December 2016 in Fuzhou City, China. Environmental factors were investigated using a self-administered questionnaire, and the expression levels of miR-126, rniR-143, and miR-145 were determined by quantitative real-time Polymerase Chain Reaction (PCR) in pe- ripheral blood mononuclear cells. Unconditional logistic regression models were used for statistical evaluation. Results Alcohol consumption, high-salt diets, high-intensity work, and lack of physical activity were significantly associated with increased CHD risk, whereas light diet was significantly associated with decreased risk. MiR-126, miR-143, and miR-145 were highly expressed in the CHD group compared with the control group. After adjustment for other environmental factors, unconditional logistic regression results revealed that miR-126, miR-143, and depression were the independent risk factors of CHD, and light diet was the independent protective factor of CHD. Conclusions Our data suggest that a family history of CHD, anxiety, and alcohol consumption was significantly associated with increased CHD risk, whereas light diet was significantly associated with decreased risk. Furthermore, miR-126 and miR-143 in combination with several risk factors, could play a joint role in the development of CHD. Therefore, it is necessary to manage patients with CHD in all directions and multiple level.展开更多
基金supported by the National University of Defense Technology Research Fund Projectthe National Natural Science Foundation of China(Grant No.12534013)the Science and Technology Innovation Program of Hunan Province(Grant Nos.2025ZYJ001 and 2021RC4026)。
摘要Understanding the complex deformation mechanisms of non-equimolar multi-principal element alloys(MPEAs)requires high-fidelity atomic-scale simulations.This study develops a deep potential(DP)model to enable molecular dynamics simulations of the Ta0.4Ti2Zr(Ta0.4)alloy.Monte Carlo simulations using this potential reveal Ta atom precipitation in the Ta0.4alloy.Under uniaxial tensile loading along the[100]direction in the NPT ensemble,the alloy undergoes a remarkable sequence of phase transformations:an initial body-centered cubic(BCC1)to face-centered cubic(FCC)transformation,followed by a reverse transformation from FCC to a distinct BCC phase(BCC2),and finally a BCC2 to hexagonal close-packed(HCP)transformation.Critically,the reverse FCC to BCC2 transformation induces significant volume contraction.We demonstrate that the inversely transformed BCC2 phase primarily accommodates compressive stress.Concurrently,the reorientation of BCC2 crystals contributes substantially to the observed high strain hardening.These simulations provide atomic-scale insights into the dynamic structural evolution,sequential phase transformations,and stress partitioning during deformation of the Ta0.4alloy.The developed DP model and the revealed mechanisms offer fundamental theoretical guidance for accelerating the design of high-performance MPEAs.
基金supported by the National Natural Science Foun-dation of China(Grant Nos.12202349,12272410,12522215,12502432)the Open Research Fund of State Key Laboratory of Target Vulnerability Assessment(Grant No.YSX2024KFXY009).
摘要Blast injury is a leading cause of military casualties,and the thorax,which houses the lungs and heart,is particularly vulnerable to blast waves.While previous studies have primarily examined anterior ex-posures,the mechanisms of thoracic response and organ injury under multi-directional blasts remain poorly understood.In this study,a validated human finite element model was employed to investigate the effects of blast wave incident direction on thoracic injury.Results indicate that interaction between blast and the thorax consistently involves reflection,diffraction,and convergence,with pressures on the loaded side dominating the overall response.Strong direction-dependent effects were observed in pressure transmission and energy distribution:under anterior loading,the heart experienced pressure amplitudes 4.2 times higher than the lungs due to density contrasts;under posterior loading,organ energy absorption decreased to 5.39%owing to chest wall constraints;and under lateral loading,impedance mismatch of the heart attenuated contralateral lung pressures by more than 90%.Lung in-juries were concentrated in the inferior lobes due to weak constraints of the lower thoracic cage,while asymmetry between left and right lung damage was attributed to organ arrangement and cage defor-mation.These findings elucidate the directional dependence of thoracic blast injury mechanisms,of-fering new insights for injury assessment and the design of protective equipment.
基金financial support from the National Natural Science Foundation of China(Grant Nos.52370086 and 52375335)the Innovative Team Program of Natural Science Foundation of Hubei Province(Grant No.2023AFA027)+4 种基金the Department of Science and Technology of Hubei Province(Grant No.2025CSA001)Hubei Key Laboratory of Mineral Resources Processing and Environment(Wuhan University of Technology)(Grant No.ZHJJ202305)the Young Elite Scientists Sponsorship Program by CAST(Grant No.2023QNRC001)the Fundamental Research Funds for the Central Universities(Grant No.2024ZYGXZR079)the State Key Laboratory of Material Processing and Die&Mould Technology(Huazhong University of Science and Technology)(Grant No.P2025-015).
摘要High-entropy alloys(HEAs)have attracted considerable interest from researchers owing to their tunable chemical compositions,exceptional structural stability,and promising catalytic properties.However,their large-scale application is often hindered by complex manufacturing techniques and poor durability.Herein,we report a simple and cost-effective threedimensional(3D)printing strategy to fabricate a 3D-FeMnCrCo HEA catalyst with precisely controlled composition,structure,and porosity.The as-prepared 3D-FeMnCrCo catalyst exhibits high printing accuracy,excellent compression resistance,and remarkable efficiency in degrading organic contaminants using peroxymonosulfate(PMS)activation.Notably,the catalyst maintains outstanding catalytic stability over 100 consecutive cycles,which outperforms most of its powdered counterparts.Theoretical calculations and controlled experiments reveal that a synergistic combination of Fe/Mn electron donation,Comediated charge buffering,and Cr-driven orbital hybridization lowers the electron transfer energy barrier,thereby enhancing PMS activation.Mechanistic studies further show that singlet oxygen is the predominant reactive species in the 3DFeMnCrCo/PMS system.The biotoxicity of degraded pollutants and the catalyst's performance in treating actual wastewater are also systematically evaluated.This work provides critical insights into the practical application of HEAs in water treatment and guides the design of efficient,stable,and easily recoverable catalysts for environmental remediation.
基金financially supported by the National Natural Science Foundation of China(No.22309138)the Hubei Province Natural Science Foundation(No.2024AFB815)+1 种基金the Postdoctoral Project of Hubei Province(No.2024HBBHXF056)the Department of Science and Technology of Hubei Province(No.2025CSA001)。
摘要As a high-energy-density primary battery,the Li-SOCl2 battery offers significant advantages over other primary systems,including a high operating voltage,wide temperature tolerance,and low self-discharge rate.However,owing to the irreversible electrochemical reaction mechanism,despite its energy density of up to 700 Wh kg-1 at the cell level,this battery system has remained confined to the category of primary batteries,thereby limiting its use in cyclic applications.Recent advances in electrochemical technologies have enabled the reversible redox chemistry of Li-SOCl2 batteries,transforming them into rechargeable systems.This article provides a systematic overview of the technical evolution,reaction mechanisms,safety constraints,engineering countermeasures,and electrochemical performance enhancement of Li-SOCl2 primary batteries since their introduction.First,the modification methods for the lithium anode,carbon cathode,electrolyte,and electrocatalyst in Li-SOCl2 primary batteries are discussed,along with their mechanisms for improving electrochemical performance.We then review the SOCl2-based rechargeable Li metal batteries(LMBs)that evolved from the Li-SOCl2 primary batteries.With their higher energy density,these systems have become promising candidates to replace traditional Li-ion batteries(LIBs).This review focuses on the construction of key components,such as the positive electrode carrier,novel alloy anode,and electrolyte,as well as their impact on electrochemical performance in rechargeable batteries.Finally,we summarize current research progress and propose future directions for SOCl2-based LMBs aimed at enhancing overall electrochemical performance.These insights provide a theoretical foundation for the development of next-generation high-energy-density energy-storage technologies.
摘要Energetic multi-principal-element alloys(EMPEAs)have garnered considerable attention for their reactive characteristics and compositional flexibility in pyrotechnic applications.However,the complex fragmentation behavior under impact loading presents challenges for optimal design.This study established a machine learning framework to predict the mean particle size(MPS)of EMPEAs under ballistic impact conditions and achieve end-to-end material design.Using ballistic gun experiment data from 110 EMPEA samples,multi-stage feature dimensionality reduction through Pearson correlation analysis and genetic algorithm identified five key predictors from 28 initial material descriptors.Among six evaluated algorithms,the AdaBoost model demonstrated optimal performance(R2=0.851).Model interpretability analysis revealed that atomic radius mismatch(ΔR),mixing entropy(ΔSmix),thermodynamic parameter(ATE),bulk modulus mismatch(ΔK),and impact velocity(v),all exhibit negative correlations with MPS,withΔR identified as the most critical factor.Symbolic regression confirmedΔR's exponential negative relationship with MPS.Ti15Zr50Ta35 EMPEA was designed and experimentally validated,achieving a quasi-static overpressure of 0.22 MPa at 1300 m/s impact velocity with sizedependent oxidation behavior in fragments,outperforming most existing energetic structural alloys.This work demonstrates the effectiveness of machine learning in understanding impact fragmentation mechanisms and facilitating the design of high-performance EMPEAs with enhanced energy release characteristics.
基金financially supported by the National Natural Science Foundation of China (Nos.62104003,21972065 and 21803002)the Natural Science Foundation of Anhui Province (No.1908085QB75)+3 种基金Anhui Provincial Natural Science Foundation for Distinguished Young Scholars (No.2008085J11)the Natural Science Foundation of Jiangsu Province (No.BK20220006)the Key projects of Anhui Provincial Department of Education,China (Nos.KJ2021ZD0044 and KJ2020A0228)Hefei National Laboratory for Physical Sciences at the Microscale (No.KF2020006)。
摘要Metal organic framework(MOF) shows great potential in the research field of photocatalysis,and it is a big challenge to achieve efficient photocatalytic activity.In this work,we have successfully grown two-dimensional MOF(2D-MOF) nanosheets on 2D-MOF nanosheets for the first time using a homometallic nodal strategy,and successfully prepared ultrathin nanosheets with tightly bound 2D/2D heterojunctions.2D Ni-BDC nanosheets were used as carriers to grow 2D Ni-TCPP nanosheets on top of them.Ni-TCPP has a high light absorption capacity,thus extending the light absorption range of 2D/2D heterojunctions.The tight coupling of the heterojunction effectively shortens the electron transfer distance,promotes the separation of interracial charges,and improves the photocatalytic activity.Particularly,Ni-BDC/Ni-TCPP-3can achieve to a hydrogen production rate of428.0 μmol·g-1,approximately 5.75 times higher than NiBDC and 5.24 times higher than Ni-TCPP,respectively.Thus,2D-MOF/2D-MOF heterojunctions provide a promising strategy for enhancing photocatalytic performance through rational heterostructure design with homometallic node strategy.
基金supported by supported by Yunnan Fundamental Research Projects(202301AT070469)National Natural Science Foundation of China under Contract(No.32460452)supported by Yunnan Major Research Projects(No.202502AB080016).
摘要Highly integrated micro-nano electronic devices suffer from severe heat dissipation challenges,and flow cooling in nanochannels is an effective solution.During convective heat transfer at liquid-solid interfaces,surface wettability and rough morphology are key parameters governing thermal transport;however,their combined effects remain unclear.In this study,molecular dynamics simulations are utilized to examine the synergistic effects of surface wettability and nanopillar arrays on thermal transport and fluid dynamics within nanochannels.The results show that increasing surface hydrophilicity and roughness reduces the thermal slip length and increases the Nusselt number,thereby enhancing heat transfer performance in the nanochannel.From a fluid dynamics standpoint,velocity slip length decreases while the relative friction coefficient increases,signifying greater flow resistance.For the present model,the enhancement in heat transfer induced by increased wettability is significantly greater than that caused by increased roughness,whereas their effects on flow resistance are difficult to distinguish the dominance.At the microscale,increased wettability and roughness facilitate the accumulation of fluid atoms near the liquid-solid interface.The elevated interaction energy between solid platinum atoms and fluid argon atoms is identified as the primary mechanism underlying thermal transport enhancement in nanochannels.This investigation offers valuable insights for the optimized thermal management of micro-nano electronic devices.
基金supported by Ningbo International Investment Consulting Co.,Ltd.
摘要This study proposes an LLM-empowered edge-cloud digital twin architecture for intelligent FM.Edge servers acquire and pre-process sensor data,with Flask-based cloud middleware aggregating into hybrid data storage.The LLM performs semantic reasoning to generate operational decisions,relaying insights in real time to a Unity-engineered 3D visualization environment.BIM semantic parsing segregates geometric from non-graphical attributes,integrating multi-source data at room-floor granularity to establish a“perception-analysis-decision-execution”closed loop,thereby enhancing situational awareness and decision support for facility managers.
基金financially supported by the State Administration for Market Regulation,China(No.2021MK050)the National Natural Science Foundation of China(Nos.50971043,51171046,21973012)+3 种基金the Key Research and Development Program of China(Nos.2022YFB3807200,CISRI-21T62450ZD)the Natural Science Foundation of Fujian Province,China(Nos.2021J01590,2020J01351,2018J01754,2020J01474)the Student Research and Training Program(SRTP) of Fuzhou University,China(No.29320)Fujian Provincial Department of Science & Technology,China(No.2021H6011)。
摘要In order to understand the influence of ordering behaviors on the thermodynamic and mechanical properties of multi-principal element alloys(MPEAs),the temperature-dependent thermodynamic properties and mechanical properties of FCC_CoNiV MPEAs were comparatively predicted,where the alloys were modeled as the ordered configurations based on our previously predicted site occupying fractions(SOFs),as well as disordered configuration based on traditional special quasi-random structure(SQS).The ordering behavior not only improves the thermodynamic stability of the structure,but also increases the elastic properties and Vickers hardness.For example,at 973 K,the predicted bulk modulus(B),shear modulus(G),Young’s modulus(E),and Vickers hardness(HV)of FCC_CoNiV MPEA based on SOFs configuration are 187.82,79.03,207.93,and 7.58 GPa,respectively,while the corresponded data are 172.58,57.45,155.14,and 4.64 GPa for the SQS configuration,respectively.The Vickers hardness predicted based on SOFs agrees considerably well with the available experimental data,while it is underestimated obviously based on SQS.
基金supported by Science&Technology Fundamental Resources Investigation Program(2022FY100800)the CAMS Innovation Fund for Medical Sciences(CIFMS)(2021-12M-1-023/2023-12M-C&T-B-005)+1 种基金Funding for Reform and Development of Beijing Municipal Health Commissionthe National High Level Hospital Clinical Research Funding(2022-PUMCH-B-094).
摘要Menopause is characterized by the cessation of menstruation and a decline in reproductive function,which is an intrinsic component of the aging process.However,it has been a frequently overlooked field of women’s health.The oral and gut microbiota,constituting the largest ecosystem within the human body,are important for maintaining human health and notably contribute to the healthy aging of menopausal women.Therefore,a comprehensive review elucidating the impact of the gut and oral microbiota on menopause for healthy aging is of paramount importance.This paper presents the current understanding of the microbiome during menopause,with a particular focus on alterations in the oral and gut microbiota.Our study elucidates the complex interplay between the microbiome and sex hormone levels,explores microbial crosstalk dynamics,and investigates the associations between the microbiome and diseases linked to menopause.Additionally,this review explores the potential of microbiome-targeting therapies for managing menopause-related diseases.Given that menopause can last for approximately 30 years,gaining insights into how the microbiome and menopause interact could pave the way for innovative interventions,which may result in symptomatic relief from menopause and an increase in quality of life in women.
基金supported by the National Natural Science Foundation of China (Grant No. 52275310)。
摘要The complex ceramic core used for hollow turbine blades requires a high porosity and a high fiexural strength. For a better balance between porosity and fiexural strength, ceramic materials with porous structures are preferred. In order to achieve the transition from disordered pore formation to ordered pore formation, Al2O3 ceramic cores with triply periodic minimal surface(TPMS) micro lattice structures with different structural configurations(gyroid, diamond, and neovius) and different volume fractions of lattice structures(30, 40, and 50, vol.%) were designed and prepared by vat photopolymerization 3D printing. The effects of structural configuration and volume fraction of the lattice structure on the following structural shrinkage, microstructure, and flexural strength were investigated. The shrinkage relationship of the three lattice configurations is: neovius>diamond>gyroid. Besides, it is found that with an increase in the volume fraction of the 3D printed Al2O3 ceramic micro lattice structures, their fiexural strength correspondingly increases ranging from 54.95 MPa to 139.1 MPa. The maximum average fiexural strength of the 3D printed Al2O3 ceramic micro lattice structures is obtained when the structural configuration is diamond and with a volume fraction of 50vol.%, which is 139.1 MPa. Even when the volume fraction of the lattice structure is 30vol.%, that is to say the porosity is 70%, the fiexural strength is as high as 50-70 MPa, which can still be maintained at a high level. In addition, when the volume fraction of the lattice structure is a certain value, the sample with diamond configuration has a higher strength. The internal pore morphology, pore size, and porosity of the cores are precisely controlled, achieving both a high porosity and a high strength. Therefore, this study maintains high porosity and high strength simultaneously, providing a new lattice structure design idea for 3D printed ceramic cores.
基金supported by a grant from the Research Grants Council of the Hong Kong Special Administrative Region,China(N_PolyU559/21)a grant from the National Natural Science Foundation of China(52161160333)+1 种基金a grant from the Research Institute for Smart Energy at The Hong Kong Polytechnic University(CDB2)supported by the Hong Kong PhD Fellowship Scheme(PF21-65328).
摘要The growing severity of environmental challenges has accelerated advancements in renewable energy technologies,highlighting the critical need for efficient energy storage solutions.Rechargeable batteries,as primary short-term energy storage devices,have seen significant progress.Among emerging optimization strategies,high-entropy electrolytes have garnered attention for their superior ionic conductivity and ability to broaden batteries’operational temperature ranges.Rooted in the thermodynamic concept of entropy,high-entropy materials,originally exemplified by high-entropy alloys,have demonstrated enhanced structural stability and advanced electrochemical performance through the synergistic integration of multiple components.High-entropy liquid electrolytes,both aqueous and non-aqueous,offer unique opportunities for entropy manipulation due to their inherently disordered structures.However,their complex compositions present challenges,as minor changes in formulation can lead to significant performance variations.This review introduces the fundamentals of entropy tuning,surveys recent advances in high-entropy liquid electrolytes,and analyzes the interplay between entropy and electrochemical behavior.Finally,it discusses design strategies and future perspectives for the practical implementation of high-entropy liquid electrolytes in next-generation energy storage systems.
基金Huaiyu Shao acknowledges the Shenzhen-Hong Kong-Macao Science and Technology Plan Project(Category C)(Grant No.SGDX20220530111004028)the Macao Science and Technology Development Fund(FDCT)for funding(FDCT No.0013/2024/RIB1,FDCT-MOST joint project No.0026/2022/AMJ and No.006/2022/ALC of the Macao Centre for Research and Development in Advanced Materials[2022–2024])+2 种基金the Multi-Year Research Grant(MYRG)from University of Macao(project No.MYRG-GRG2023-00140-IAPME-UMDF and No.MYRG-GRG2024-00206-IAPME)Natural Science Foundation of Guangdong Province(Grant No.2023A1515010765)Science and Technology Program of Guangdong Province of China(Grant No.2023A0505030001)。
摘要Considering the growing pre-lithiation demand for high-performance Si-based anodes and consequent additional costs caused by the strict pre-lithiation environment,developing effective and environmentally stable pre-lithiation additives is a challenging research hotspot.Herein,interfacial engineered multifunctional Li13Si4@perfluoropolyether(PFPE)/LiF microanoparticles are proposed as anode pre-lithiation additives,successfully constructed with the hybrid interface on the surface of Li13Si4through PFPE-induced nucleophilic substitution.The synthesized multifunctional Li13Si4@PFPE/LiF realizes the integration of active Li compensation,long-term chemical structural stability in air,and solid electrolyte interface(SEI)optimization.In particular,the Li13Si4@PFPE/LiF with a high pre-lithiation capacity(1102.4 mAh g-1)is employed in the pre-lithiation Si-based anode,which exhibits a superior initial Coulombic efficiency of 102.6%.Additionally,in situ X-ray diffraction/Raman,density functional theory calculation,and finite element analysis jointly illustrate that PFPE-predominant hybrid interface with modulated abundant highly electronegative F atoms distribution reduces the water adsorption energy and oxidation kinetics of Li13Si4@PFPE/LiF,which delivers a high pre-lithiation capacity retention of 84.39%after exposure to extremely moist air(60%relative humidity).Intriguingly,a LiF-rich mechanically stable bilayer SEI is constructed on anodes through a pre-lithiation-driven regulation for the behavior of electrolyte decomposition.Benefitting from pre-lithiation via multifunctional Li13Si4@PFPE/LiF,the full cell and pouch cell assembled with pre-lithiated anodes operate with long-time stability of 86.5%capacity retention over 200 cycles and superior energy density of 549.9 Wh kg-1,respectively.The universal multifunctional pre-lithiation additives provide enlightenment on promoting large-scale applications of pre-lithiation on commercial high-energy-density and long-cycle-life lithium-ion batteries.
基金supported by the National Natural Science Foundation of China(No.41571062)the Fundamental Research Funds for the Central Universities(No.2021TS014)the Natural Science Basic Research Plan in Shaanxi Province of China(No.2023-JC-YB-259).
摘要Formaldehyde(HCHO)is a high-yield product of the oxidation of volatile organic compounds(VOCs)released by anthropogenic activities,fires,and vegetations.Hence,we examined the spatiotemporal variation trends in HCHO columns observed using the Ozone Monitoring Instrument(OMI)during 2005–2021 across the Fenwei Plain(FWP)and analysed the source and variability of HCHO using multi-source data,such as thermal anomalies.The spatial distribution of the annualmean HCHO in the FWP increased from northwest to southeast during 2005–2021,and the high-value aggregation areas contracted and gradually clustered,forming a belt-shaped distribution area from Xi’an to Baoji,north of the Qinling Mountains.The annual mean HCHO concentration generally showed a two-step increase over the 17 years.Fires showed a single-peak trend in March and a double-peak M-shaped trend in March and October,whereas urban thermal anomalies(UTAs)showed an inverted U-shaped trend over 17 years,with peaks occurring in May.The HCHO peaks are mainly caused by the alternating contributions of fires and UTAs.The fires and UTAs(predominantly industrial heat sources)played a role in controlling the background level of HCHO in the FWP.Precipitation and temperature were also important influencing variables for seasonal variations,and the influence of plant sources on HCHO concentrations had significant regional characteristics and contributions.In addition,the FWP has poor dispersion conditions and is an aggregated area for the long-range transport of air pollutants.
基金The Educational Reform of Xi’an University of Posts and Telecommunications for Postgraduate Programs,“Integrating Chinese and English Discourses:An Exploration of the Optimization Path for the MTI Training Model Driven by PBL Theory”(Project No.:YJGJ2024034)。
摘要In recent years,subtitling has emerged as a prominent topic in the field of translation studies.This paper conducts a quantitative analysis of literature related to“subtitling”retrieved from the China National Knowledge Infrastructure(CNKI),focusing on sources indexed in the CSSCI and Peking University Core Journals databases.Utilizing the bibliometric tool CiteSpace,the study reviews the research hotspots and developmental trends in Chinese subtitling studies over the past two decades.The findings reveal that,driven by the growth of the film and television industry,deepening cross-cultural communication,and continuous technological advancements,research in this field has gradually shifted from theoretical exploration to practical application.The focus has become increasingly refined,diversified,and intelligent,expanding into interdisciplinary and multimodal translation studies.The paper also discusses current limitations in the research and outlines future directions,offering targeted suggestions to provide valuable references for further studies and practical endeavors in this domain.
基金supported by the National Natural Science Foundation of China,No.81571292(to XJZ)、81601152(to YY)the Natural Science Foundation of Hebei Province of China,No.H2017206338(to RC)
摘要Rosmarinic acid(RA) can elicit a neuroprotective effect against ischemic stroke, but the precise molecular mechanism remains poorly understood. In this study, an experimental ischemic stroke model was established in CD-1 mice(Beijing Vital River Laboratory Animal Technology, Beijing, China) by occluding the right middle cerebral artery for 1 hour and allowing reperfusion for 24 hours. After intraperitoneally injecting model mice with 10, 20, or 40 mg/kg RA, functional neurological deficits were evaluated using modified Longa scores. Subsequently, cerebral infarct volume was measured using TTC staining and ischemic brain tissue was examined for cell apoptosis with TUNEL staining. Superoxide dismutase activity and malondialdehyde levels were measured by spectrophometry. Expression of heme oxygenase-1(HO-1), nuclear factor erythroid 2-related factor 2(Nrf2), Bcl-2, Bax, Akt, and phospho-Ser473 Akt proteins in ischemic brain tissue was detected by western blot, while mRNA levels of Nrf2, HO-1, Bcl-2, and Bax were analyzed using real time quantitative PCR. In addition, HO-1 enzyme activity was measured spectrophotometrically. RA(20 and 40 mg/kg) greatly improved neurological function, reduced infarct volume, decreased cell apoptosis, upregulated Bcl-2 protein and mRNA expression, downregulated Bax protein and mRNA expression, increased HO-1 and Nrf2 protein and mRNA expression, increased superoxide dismutase activity, and decreased malondialdehyde levels in ischemic brain tissue of model mice. However, intraperitoneal injection of a HO-1 inhibitor(10 mg/kg zinc protoporphyrin IX) reversed the neuroprotective effects of RA on HO-1 enzyme activity and Bcl-2 and Bax protein expression. The PI3 K/Akt signaling pathway inhibitor LY294002(10 mM) inhibited Akt phosphorylation, as well as Nrf2 and HO-1 expression. Our findings suggest that RA has anti-oxidative and anti-apoptotic properties that protect against ischemic stroke by a mechanism involving upregulation of Nrf2 and HO-1 expression via the PI3 K/Akt signaling pathway.
基金supported by the State Key R&D Project of the Ministry of Science and Technology of China(No.2016YFC06002010).
摘要There are widespread Mesozoic–Cenozoic terrestrial volcanic activities in East China,and they produced favorable geologic factors for the volcanic reservoirs.To reveal the spatio-temporal evolution of regional volcanisms and their tectonic setting,we subdivide Mesozoic–Cenozoic volcanic activities into 6 volcanic cycles(Ⅰ–Ⅵ),and summarize the temporal-spatial distribution,rock association and tectonic setting of each cycle.The Cycle I forms a post-orogenic intraplate bimodal volcanic association.The cyclesⅡandⅢinclude arc volcanic associations formed in compressional and extensional subduction environments,respectively.The CycleⅣcontains a post-orogenic arc bimodal association.The CycleⅤis a basaltic association of tholeiite series under initial rift setting,and the CycleⅥis basaltic association of alkaline series under typical rift setting.The volcanic strata between each cycle are bounded by regional unconformity.The above 6 volcanic cycles correspond to 6 sequential stages of tectonic evolutions from the Early Jurassic post-orogeny,the Mid-Jurassic–Cretaceous subduction of the paleo-Pacific Plate to the Cenozoic marginal rifting.According to the geological characteristics of volcanic reservoirs in different volcanic cycles,it is put forward that the CycleⅤis the major formation period of volcanic reservoirs in East China and should be the focus of exploration,and that the volcanic reservoirs of the CycleⅣare also worthy of attention.
基金supported by the National Nature Science Foundation of China(No.81302772)Jiangsu Provincial Medical Talent Project(No.QNRC2016716)
摘要The present study was designed to elucidate whether the mechanism by which osthole decreases collagenⅠ/III contents and their ratio is regulating the TGF-β/Smad signaling pathway in TGF-β1-overexpressed mouse cardiac fibroblasts(CFs). These CFs were cultured and treated with different concentrations of osthole. Our results showed that the TGF-β1 expression in the CFs transfected with that the recombinant expression plasmids pc DNA3.1(+)-TGF-β1 was significantly enhanced. After the CFs were treated with 1.25-5 μg·m L-1 of osthole for 24 h, the m RNA and protein expression levels of collagensⅠand III were reduced. The collagen Ⅰ/III ratio was also reduced. The m RNA and protein expression levels of TGF-β1, TβRⅠ, Smad2/3, P-Smad2/3, Smad4, and α-SMA were decreased, whereas the expression level of Smad7 was increased. These effects suggested that osthole could inhibit collagen Ⅰ and III expression and reduce their ratio via the TGF-β/Smad signaling pathway in TGF-β1 overexpressed CFs. These effects of osthole may play beneficial roles in the prevention and treatment of myocardial fibrosis.
基金This study was financially supported by the Hunan Provin-cial Natural Science Foundation of China(Grant No.2022JJ10058)the National Natural Science Foundation of China(Grant Nos.12072369 and 52171166).The authors thank Dr.Xuehao Zheng from the ZKKF(Beijing)Science and Technology Company of China for supporting the SEM and TEM analyses.The authors would like to acknowledge Dr.Xiang Wu from KAIPLE Centre for Microscopy,Characterisation&Analysis(CMCA)of China for supporting the EBSD analyzes.
摘要In this study,the dynamic compressive response behavior of a body-centered cubic(BCC)single-phase TiZrNbV refractory high-entropy alloy(RHEA)was investigated under impact at speeds of 313-1584 m s-1using two-stage,gas-gun-driven,high-speed plate-impact experiments;recovery sample analysis;and theoretical calculations.The strain rate and pressure were approximately 107 s−1 and 5.07-29.37 GPa,respectively.The results showed that the TiZrNbV RHEA had a Hugoniot elastic limit of 4.12-5.86 GPa and a spall strength of 1.84-2.03 GPa.The initial yield strength of the alloy showed a strong strain-rate dependence and could be described by the modified Zerilli-Armstrong model,while the phonon-damping effect was the main reason for its high strain-rate sensitivity.Microstructural analysis showed that the dynamic deformation of the TiZrNbV RHEA was controlled by the dislocation slip,dislocation proliferation,intersection of the deformation bands,and grain refinement.The analysis also showed that the intergranular,transgranular,and mixed-type cracks dominated the spall failure of the material.The dynamic Hall-Petch effect and pinning from the lattice distortion led to high dynamic yield strength.The critical strain rate for the phonon drag effect was positively related to the relative atomic mass and local strain field of the metals.Within the experimental loading range,the RHEA showed good structural stability,and simultaneously,the theoretical calculation method for the equation of state based on a cold-energy mixture could accurately predict its shock-response behavior.The valence-electron concentration(VEC)had a direct effect on the shock-compression properties of the HEAs;higher VEC implied more difficulty in compressing the HEAs.The findings of this study provide insights into understanding the mechanical response characteristics of RHEAs under extreme conditions such as high-speed impact and ultrahigh strain-rate loading.
摘要Objective To evaluate the effects of environmental factors and microRNAs (miRNAs) (miR-126, miR-143, and miR-145) on the risk of coronary heart disease (CHD). Methods A frequency-matched case-control study (450 patients, 450 controls) was conducted from April 2014 to December 2016 in Fuzhou City, China. Environmental factors were investigated using a self-administered questionnaire, and the expression levels of miR-126, rniR-143, and miR-145 were determined by quantitative real-time Polymerase Chain Reaction (PCR) in pe- ripheral blood mononuclear cells. Unconditional logistic regression models were used for statistical evaluation. Results Alcohol consumption, high-salt diets, high-intensity work, and lack of physical activity were significantly associated with increased CHD risk, whereas light diet was significantly associated with decreased risk. MiR-126, miR-143, and miR-145 were highly expressed in the CHD group compared with the control group. After adjustment for other environmental factors, unconditional logistic regression results revealed that miR-126, miR-143, and depression were the independent risk factors of CHD, and light diet was the independent protective factor of CHD. Conclusions Our data suggest that a family history of CHD, anxiety, and alcohol consumption was significantly associated with increased CHD risk, whereas light diet was significantly associated with decreased risk. Furthermore, miR-126 and miR-143 in combination with several risk factors, could play a joint role in the development of CHD. Therefore, it is necessary to manage patients with CHD in all directions and multiple level.