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Multidisciplinary cutting-edge technologies accelerating target-based drug discovery 认领 引用
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作者 Yanting Li Ruin Moaddel +1 位作者 Zhengjin Jiang Xiaofei Chen 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2026年第2期313-314,共2页
Drug discovery has begun to move beyond traditional targets,turning instead to more complex target landscapes.These complex targets,including membrane proteins,are characterized by their environment and conformational... Drug discovery has begun to move beyond traditional targets,turning instead to more complex target landscapes.These complex targets,including membrane proteins,are characterized by their environment and conformational mobility.A limitation of traditional in vitro screening is that the target protein is not in its native environment.As a result,there is a need to go beyond current methods,this will allow you to study a target proteins functional activity in their native environment. 展开更多
关键词 technologies multidisciplinary cutting edge drug discovery vitro screening study target proteins functional activity membrane proteinsare target based
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Target-based Drug Screening 认领 引用
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作者 Xiaofei Chen Zhengjin Jiang Ruin Moaddel 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2026年第2期F0004-F0004,共1页
Target-based and phenotype-based methods are the two main approaches for drug screening.Target-based drug screening focuses on specific targets highly correlated with disease mechanisms,by detecting protein-ligand bin... Target-based and phenotype-based methods are the two main approaches for drug screening.Target-based drug screening focuses on specific targets highly correlated with disease mechanisms,by detecting protein-ligand binding structure,dynamics and affinity.Currently,the four mainstream drug targets are G protein-coupled receptors(GPCRs),kinases,ion channels,and nuclear receptors,accounting for over 70%of effective drug targets,most of which are membrane proteins and enzymes. 展开更多
关键词 Drug target ·Drug screening Methods Affinity Drug-target interaction Active substances
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Editorial of Special Column “Natural Product Screening” 认领 引用
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作者 Ruin Moaddel Zhengjin Jiang 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2020年第10期1798-1799,1797,共2页
Nature has produced a rich diversity of structurally complex compounds or secondary metabolites with a wide variety of biological activities.Natural products have long been exploited for therapeutic purposes in tradit... Nature has produced a rich diversity of structurally complex compounds or secondary metabolites with a wide variety of biological activities.Natural products have long been exploited for therapeutic purposes in traditional medicines around the world.Recently,it was reported almost half of the 1562 new approved drugs introduced between 1981 and 2014 are natural products or derived from natural products or biological^1. 展开更多
关键词 drugs therapeutic Natural
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