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Probiotic Akkermansia muciniphila alleviates acute kidney injury by protecting the intestinal barrier and modulating gut microbiota and metabolites 认领 引用
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作者 Juan Ni Zhan Yang +11 位作者 Xuewei Sun Qian Cui Ruonan Zhang Han Lu Zihan Wu Jingfeng Zhu Huijuan Mao Kang Liu Chengliang Tang Chunhui Wang Changying Xing Jin Zhu 《Journal of Biomedical Research》 CAS CSCD 2026年第1期76-88,共13页
Acute kidney injury(AKI)is a critical condition with limited effective therapies.Akkermansia muciniphila(A.muciniphila)is a probiotic with multiple beneficial effects,including the regulation of epithelial cell tight ... Acute kidney injury(AKI)is a critical condition with limited effective therapies.Akkermansia muciniphila(A.muciniphila)is a probiotic with multiple beneficial effects,including the regulation of epithelial cell tight junctions.Since renal pathophysiology is associated with gut barrier integrity,we hypothesized that A.muciniphila may have preventive effects on AKI.We established a lipopolysaccharide(LPS)-induced AKI mouse model to evaluate the effects of A.muciniphila.Our findings showed that pretreatment with A.muciniphila significantly attenuated kidney injury,as evidenced by reduced serum creatinine and urea nitrogen levels,alongside decreased tubular necrosis and apoptosis.A.muciniphila preserved intestinal barrier integrity and induced marked shifts in gut microbial ecology and the metabolome.A.muciniphila notably induced an increase in the relative abundance of the phylum Proteobacteria while decreasing in that of the phylum Bacteroidetes.At the genus level,Prevotella,Faecalibaculum,Moraxella,and Lactobacillus were more abundant in A.muciniphilapretreated mice.Metabolomic analysis revealed that A.muciniphila altered the gut metabolome,with changes involving pathways such as tyrosine metabolism,alanine/aspartate/glutamate homeostasis,cancer-related carbon flux,and GABAergic synaptic signaling.In conclusion,our findings indicate that A.muciniphila exerts renoprotective effects by modulating the gut-kidney axis,thereby establishing a foundation for future studies to explore the connection between gut microbiota and AKI. 展开更多
关键词 Akkermansia muciniphila acute kidney injury gut-kidney axis metabolomics gut microbiota dysbiosis
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BaTiO3 Nanoparticle-Induced Interfacial Electric Field Optimization in Chloride Solid Electrolytes for 4.8V All-Solid-State Lithium Batteries 认领 引用 被引量：1
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作者 Qingmei Xiao Shiming Huang +4 位作者 Donghao Liang Cheng Liu Ruonan Zhang Wenjin Li Guangliang Gary Liu 《Nano-Micro Letters》 SCIE EI CAS CSCD 2026年第2期404-420,共17页
Chloride-based solid electrolytes are considered promising candidates for next-generation high-energy-density all-solid-state batteries(ASSBs).However,their relatively low oxidative decomposition threshold(~4.2 V vs.L... Chloride-based solid electrolytes are considered promising candidates for next-generation high-energy-density all-solid-state batteries(ASSBs).However,their relatively low oxidative decomposition threshold(~4.2 V vs.Li+/Li)constrains their use in ultrahighvoltage systems(e.g.,4.8 V).In this work,ferroelectric Ba TiO3(BTO)nanoparticles with optimized thickness of~50-100 nm were successfully coated onto Li2.5Y0.5Zr0.5Cl6(LYZC@5BTO)electrolytes using a time-efficient ball-milling process.The nanoparticle-induced interfacial ionic conduction enhancement mechanism contributed to the preservation of LYZC’s high ionic conductivity,which remained at 1.06 m S cm-1for LYZC@5BTO.Furthermore,this surface electric field engineering strategy effectively mitigates the voltage-induced self-decomposition of chloride-based solid electrolytes,suppresses parasitic interfacial reactions with single-crystal NCM811(SCNCM811),and inhibits the irreversible phase transition of SCNCM811.Consequently,the cycling stability of LYZC under high-voltage conditions(4.8 V vs.Li+/Li)is significantly improved.Specifically,ASSB cells employing LYZC@5BTO exhibited a superior discharge capacity of 95.4 m Ah g-1over 200 cycles at 1 C,way outperforming cell using pristine LYZC that only shows a capacity of 55.4 m Ah g-1.Furthermore,time-of-flight secondary ion mass spectrometry and X-ray photoelectron spectroscopy analysis revealed that Metal-O-Cl by-products from cumulative interfacial side reactions accounted for 6% of the surface species initially,rising to 26% after 200 cycles in pristine LYZC.In contrast,LYZC@5BTO limited this increase to only 14%,confirming the effectiveness of BTO in stabilizing the interfacial chemistry.This electric field modulation strategy offers a promising route toward the commercialization of high-voltage solid-state electrolytes and energy-dense ASSBs. 展开更多
关键词 All-solid-state batteries Chloride electrolyte Ferroelectric BaTiO3 High-voltage stability Surface modification
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UAV-enabled aerial active RIS with learning deployment for secured wireless communications 认领 引用 被引量：2
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作者 Xiao TANG Zhihao XIONG +2 位作者 Limeng DONG Ruonan ZHANG Qinghe DU 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2025年第10期107-119,共13页
Reconfigurable Intelligent Surfaces(RISs)enable programmable wireless environments and thus have great potential for enhancing physical layer security.However,the security gain of conventional passive RISs is often li... Reconfigurable Intelligent Surfaces(RISs)enable programmable wireless environments and thus have great potential for enhancing physical layer security.However,the security gain of conventional passive RISs is often limited by the“multiplicative fading”effect through reflection links,which becomes severe in the case of double reflections and significantly degrades the security performance.In this paper,we consider a wireless system that consists of a fixed passive RIS and an Unmanned Aerial Vehicle(UAV)-mounted active RIS,where the UAV-enabled aerial amplification and reflection are exploited to compensate for the multiplicative fading effect.We formulate the problem to maximize the secrecy rate by jointly considering the optimal deployment of the UAV-based active RIS and the reflection coefficients at both the passive and active RISs.To enable efficient algorithm design,we decompose the problem into two layers:the outer layer optimizes the UAV deployment through deep reinforcement learning,while the inner layer solves the beamforming and reflection design using a block coordinate descent framework.Simulation results demonstrate the convergence of the proposed learning procedure,and indicate that the active RIS with learned deployment can effectively enhance the reflection and significantly improve the secrecy rate. 展开更多
关键词 Physical layer security Reconfigurable intelligent surface Unmanned aerial vehicle Block coordinate descent Deep reinforcement learning
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Overview of the studies on the interactions between atmosphere,sea ice,and ocean in the Arctic Ocean and its climatic effects:Contributions from Chinese scientists 认领 引用
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作者 Ruibo Lei Fanyi Zhang +6 位作者 Qinghua Yang Ruonan Zhang Wenli Zhong Qi Shu Minghu Ding Fengming Hui Chao Min 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2025年第3期3-34,共32页
The year,2024,marks the 40th anniversary of Chinese research expeditions in the polar regions and the 25th anniversary of its Arctic research expeditions.China has conducted 14 national Arctic research expeditions.Wit... The year,2024,marks the 40th anniversary of Chinese research expeditions in the polar regions and the 25th anniversary of its Arctic research expeditions.China has conducted 14 national Arctic research expeditions.With the increase of understandings on the global impacts of the changes of Arctic climate system,especially on China’s weather and climate,and demands for commercial utilization of the Arctic sea routes,Chinese scientists have made great progresses on in site and remote sensing observation technologies for Arctic Ocean,interaction mechanisms between atmosphere,sea ice,and ocean,the connection mechanism between the Arctic Ocean and other regions,and have achieved a series of research results.This study summarizes the research achievements by Chinese scientists in the above-mentioned aspects or beyond,identifies knowledge gaps,and based on this,discusses prospects and provides suggestions.From a perspective of observation,improving the observation capabilities of the Arctic Ocean in winter and the ocean under the ice,as well as floe-scale processes of sea ice and mesoscale and submesoscale processes of the ocean,is an urgent task to be addressed.Strengthening international cooperation is necessary for building a monitoring network for the Arctic marine environment.From a perspective of numerical simulation,the descriptive ability and parameterization scheme of sub-grid processes based on observational evidence need to be developed.From a perspective of cross-sphere interactions,in addition to the multi-media coupling within the Arctic Ocean that this review focuses on,the interaction between the Arctic Ocean and land or ice sheet(Greenland),especially the water cycle process,is also a scientific domain that needs to be considered,in the context of Arctic warming and humidification.From a perspective of climate effects,the physical mechanisms that affect the robustness of teleconnection need to be clarified. 展开更多
关键词 Chinese National Arctic Research Expedition(CHINARE) Arctic Ocean atmosphere sea ice climate
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Strong interaction between Fe and Ti compositions for effective CO2hydrogenation to light olefins 认领 引用
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作者 Hao Liang Shunan Zhang +4 位作者 Ruonan Zhang Haozhi Zhou Lin Xia Yuhan Sun Hui Wang 《Chinese Journal of Catalysis》 SCIE EI CAS CSCD 2025年第4期146-157,共12页
Fe-based catalysts are widely used for CO2hydrogenation to light olefins(C2–4=);however,precise regulation of active phases and the balance between intermediate reactions remain significant challenges.Herein,we... Fe-based catalysts are widely used for CO2hydrogenation to light olefins(C2–4=);however,precise regulation of active phases and the balance between intermediate reactions remain significant challenges.Herein,we find that the addition of moderate amounts of Ti forms a strong interaction with Fe compositions,modulating the Fe3O4and Fe5C2contents.Enhanced interaction leads to an increased Fe5C2/Fe3O4ratio,which in turn enhances the adsorption of reactants and intermediates,promoting CO hydrogenation to unsaturated alkyl groups and facilitating C–C coupling.Furthermore,the strong Fe-Ti interaction induces the preferential growth of Fe5C2into prismatic structures that expose the(020),(–112),and(311)facets,forming compact active interfacial sites with Fe3O4nanoparticles.These facet and interfacial effects significantly promote the synergistic coupling of the reverse water gas shift and Fischer-Tropsch reactions.The optimized 3K/FeTi catalyst with the highest Fe5C2/Fe3O4ratio of 3.6 achieves a 52.2%CO2conversion rate,with 44.5%selectivity for C2–4=and 9.5%for CO,and the highest space-time yield of 412.0 mg gcat–1h–1for C2–4=. 展开更多
关键词 CO2hydrogenation Light olefins Strong Fe-Ti interaction Fe5C2 Active phase modulation
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Cordycepin ameliorates brown adipose tissue whitening induced by long-term continuous light exposure via the AMPK/PGC-1α/UCP1 signaling pathway 认领 引用
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作者 Ruonan Zhang Li Zhang +6 位作者 Yuqing Jiang Zhiwei Zhao Guanyu Zhang Yongqiang Zhang Shuai Wu Xi Li Danfeng Yang 《Frigid Zone Medicine》 2025年第3期129-140,I0003,I0004,共12页
Background:Long-term exposure to light has emerged as a novel risk factor for metabolic diseases.The whitening of brown adipose tissue(BAT)may play an important role in metabolic disorders caused by long-term continuo... Background:Long-term exposure to light has emerged as a novel risk factor for metabolic diseases.The whitening of brown adipose tissue(BAT)may play an important role in metabolic disorders caused by long-term continuous light exposure.This study aimed to investigate the morphological and functional alterations in BAT under continuous light conditions and to identify traditional Chinese medicine compounds capable of reversing these changes.Methods:A metabolic disorder model was established by subjecting mice to continuous light exposure for 5 weeks.During this period,body weight,food intake,and body fat percentage were monitored.Serum levels of triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),and low density lipoprotein cholesterol(LDL-C)were measured to assess lipid metabolism.Histological changes in BAT were examined using H&E staining.The expression of the thermogenic marker uncoupling protein 1(UCP1)in BAT was determined by RT-qPCR and Western blot to evaluate thermogenic function.RNA sequencing(RNA-seq)was employed to identify differentially expressed genes(DEGs)involved in BAT whitening induced by prolonged continuous light exposure.DEGs were analyzed using the connectivity map(CMap)database to identify potential preventive and therapeutic compounds.The therapeutic efficacy of the selected compounds was subsequently evaluated using the above indicators,and key pathways were validated through western blot analysis.Results:After 5 weeks of continuous light exposure,mice exhibited increased body fat percentage and serum levels of TG,impaired mitochondrial function,reduced thermogenic capacity,and whitening of BAT.Gene ontology(GO)and Kyoto encyclopedia of genes and genomes(KEGG)enrichment analyses indicated that BAT whitening was primarily associated with the adenosine 5'-monophosphate-activated protein kinase(AMPK)signaling pathway,fatty acid metabolism,and circadian rhythm.Ten hub genes identified using Cytoscape were mainly related to AMPK signaling and heat shock proteins.In vivo experiments showed that cordycepin significantly attenuated the increase in body fat percentage caused by prolonged light exposure.This effect was mediated by activation of the AMPK/PGC-1α/UCP1 signaling pathway,which restored the multilocular morphology and thermogenic function of BAT.Conclusion:Cordycepin mitigates continuous light-induced BAT whitening and metabolic disturbances by activating the AMPK signaling pathway. 展开更多
关键词 long-term continuous light brown adipose tissue whitening cordycepin AMPK
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Preparation, characterization, pharmacokinetics and anticancer effects of PEGylated β-elemene liposomes 认领 引用 被引量：10
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作者 Bingtao Zhai Qibiao Wu +15 位作者 Wengang Wang Mingming Zhang Xuemeng Han Qiujie Li Peng Chen Xiaying Chen Xingxing Huang Guohua Li Qin Zhang Ruonan Zhang Yu Xiang Shuiping Liu Ting Duan Jianshu Lou Tian Xie Xinbing Sui 《Cancer Biology & Medicine》 SCIE CAS CSCD 2020年第1期60-75,共16页
Objective:This study aimed to develop a new polyethylene glycol(PEG)ylatedβ-elemene liposome(PEG-Lipo-β-E)and evaluate its characterization,pharmacokinetics,antitumor effects and safety in vitro and in vivo.Methods:... Objective:This study aimed to develop a new polyethylene glycol(PEG)ylatedβ-elemene liposome(PEG-Lipo-β-E)and evaluate its characterization,pharmacokinetics,antitumor effects and safety in vitro and in vivo.Methods:The liposomes were prepared by ethanol injection and high-pressure micro-jet homogenization.Characterization of the liposomes was conducted,and drug content,entrapment efficiency(EE),in vitro release and stability were studied by ultra-fast liquid chromatography(UFLC)and a liquid surface method.Blood was drawn from rats to establish the pharmacokinetic parameters.The anticancer effect was evaluated in a KU-19-19 bladder cancer xenograft model.Histological analyses were performed to evaluate safety.Results:The PEG-Lipo-β-E showed good stability and was characterized as 83.31±0.181 nm in size,0.279±0.004 in polydispersity index(PDI),-21.4±1.06 mV in zeta potential,6.65±0.02 in pH,5.024±0.107 mg/mL inβ-elemene(β-E)content,and 95.53±1.712%in average EE.The Fourier transform infrared spectroscopy(FTIR)and differential scanning calorimetry(DSC)indicated the formation of PEG-Lipo-β-E.Compared to elemene injection,PEG-Lipo-β-E demonstrated a 1.75-fold decrease in clearance,a 1.62-fold increase in half-life,and a 1.76-fold increase in area under the concentration-time curves(AUCs)from 0 hour to 1.5 hours(P<0.05).PEG-Lipo-β-E also showed an enhanced anticancer effect in vivo.Histological analyses showed that there was no evidence of toxicity to the heart,kidney,liver,lung or spleen.Conclusions:The present study demonstrates PEG-Lipo-β-E as a new formulation with ease of preparation,high EE,good stability,improved bioavailability and antitumor effects. 展开更多
关键词 β-elemene PEGylated liposome pharmacokinetics antitumor effect bladder cancer
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An ATF24 peptide-functionalized β-elemene-nanostructured lipid carrier combined with cisplatin for bladder cancer treatment 认领 引用 被引量：9
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作者 Bingtao Zhai Peng Chen +18 位作者 Wengang Wang Shuiping Liu Jiao Feng Ting Duan Yu Xiang Ruonan Zhang Mingming Zhang Xuemeng Han Xiaying Chen Qiujie Li Guohua Li Ying Liu Xingxing Huang Wenzheng Zhang Ting Pan Lili Yan Ting Jin Tian Xie Xinbing Sui 《Cancer Biology & Medicine》 SCIE CAS CSCD 2020年第3期676-692,共17页
Objective:In this study,we aimed to develop an amino-terminal fragment(ATF)peptide-targeted liposome carryingβ-elemene(ATF24-PEG-Lipo-β-E)for targeted delivery into urokinase plasminogen activator receptor-overexpre... Objective:In this study,we aimed to develop an amino-terminal fragment(ATF)peptide-targeted liposome carryingβ-elemene(ATF24-PEG-Lipo-β-E)for targeted delivery into urokinase plasminogen activator receptor-overexpressing bladder cancer cells combined with cisplatin(DDP)for bladder cancer treatment.Methods:The liposomes were prepared by ethanol injection and high-pressure microjet homogenization.The liposomes were characterized,and the drug content,entrapment efficiency,andin vitro release were studied.The targeting efficiency was investigated using confocal microscopy,ultra-fast liquid chromatography,and an orthotopic bladder cancer model.The effects of ATF24-PEG-Lipo-β-E combined with DDP on cell viability and proliferation were evaluated by a Cell Counting Kit-8(CCK-8)assay,a colony formation assay,and cell apoptosis and cell cycle analyses.The anticancer effects were evaluated in a KU-19-19 bladder cancer xenograft model.Results:ATF24-PEG-Lipo-β-E had small and uniform sizes(~79 nm),high drug loading capacity(~5.24 mg/mL),high entrapment efficiency(98.37±0.95%),and exhibited sustained drug release behavior.ATF24-PEG-Lipo-β-E had better targeting efficiency and higher cytotoxicity than polyethylene glycol(PEG)ylatedβ-elemene liposomes(PEG-Lipo-β-E).DDP,combined with ATF24-PEG-Lipo-β-E,exerted a synergistic effect on cellular apoptosis and cell arrest at the G2/M phase,and these effects were dependent on the caspase-dependent pathway and Cdc25C/Cdc2/cyclin B1 pathways.Furthermore,thein vivo antitumor activity showed that the targeted liposomes effectively inhibited the growth of tumors,using the combined strategy.Conclusions:The present study provided an effective strategy for the targeted delivery ofβ-elemene(β-E)to bladder cancer,and a combined strategy for bladder cancer treatment. 展开更多
关键词 uPAR β-elemene active targeting liposome bladder cancer DDP
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Simultaneously enhancing mechanical and tribological properties of carbon fiber composites by grafting SiC hexagonal nanopyramids for brake disk application 认领 引用 被引量：6
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作者 Yao Guo Leilei Zhang +6 位作者 Qiang Song Ruonan Zhang Fei Zhao Wei Li Hongchao Sheng Xianghui Hou Hejun Li 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2022年第26期1-8,共8页
Extensive attention has been drawn to the development of carbon fiber composites for their application in brake disks due to the increasing demand for brake disks with high mechanical strength and better tribological ... Extensive attention has been drawn to the development of carbon fiber composites for their application in brake disks due to the increasing demand for brake disks with high mechanical strength and better tribological properties.Herein,we design SiC hexagonal nanopyramids modified carbon/carbon(SiCNPsC/C)composites,in which SiCNPs are radially grafted on the carbon fibers by the combined sol-gel and carbothermal reduction method,and pyrolytic carbon(Py C)matrix is deposited on nucleation sites including carbon fibers and SiCNPs by isothermal chemical vapor infiltration(ICVI).Benefiting from the special structure,SiCNPs-C/C composites exhibit superior mechanical and frictional performance.Compared with C/C composites,SiCNPs-C/C composites have 147%,90.3%,70.6%,and 117.9%improvement in the hardness,interlaminar shear strength,and out-of-plane and in-plane compressive strength,respectively,which is attributed to the optimized fiber/matrix(F/M)interfaces bonding and the enhanced cohesion strength of Py C matrix.In addition,the friction coefficient of SiCNPs-C/C composites increases by 25.5%,and the wear rate decreases by 38.0%.This work provides an optional design thought for the nanomaterials and enlightens the mechanical and frictional modification of composites in the field of the brakes. 展开更多
关键词 SiC hexagonal nanopyramids Carbon/carbon composites Microstructure Mechanical properties Tribological properties
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Thermal insulating and fire-retardant Si3N4 nanowire membranes resistant to high temperatures up to 1300℃ 认领 引用 被引量：2
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作者 Yeye Liu Leilei Zhang +4 位作者 Ruonan Zhang Siqi Shao Lina Sun Xinyi Wan Tiantian Wang 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2023年第24期82-88,共7页
Superior thermal insulating and fire-retardant ceramic membranes are urgently demanded in the aerospace,construction,and chemical engineering industries.However,the generic characteristics of ceramic membranes,such as... Superior thermal insulating and fire-retardant ceramic membranes are urgently demanded in the aerospace,construction,and chemical engineering industries.However,the generic characteristics of ceramic membranes,such as brittleness,structural collapse,and crystallization-induced pulverization behavior,present a great plague to their practical applications.Herein,we report a highly flexible,mechanically stable,fire-retardant,and high-temperature-resistant ceramic membrane based on the interlocked Si3N4 nanowires formed by the precursor pyrolysis method.The Si3N4 nanowire membrane(SNM)has excellent high-temperature resistance under alcohol lamps and butane spray lance.The thermal insulation with a thermal conductivity as low as 0.056 W m-1K-1can be attributed to the high porosity of SNM,which makes it a desirable candidate for heat insulators under harsh conditions.More importantly,SNM exhibits thermal stability and robust mechanical properties in the range of 25 to 1300℃.The high-temperature resistance of SNM up to 1300℃is achieved by the four stages:Si3 N4 nanowires,Si3N4@SiO2 nanowires,SiO2 nanowires,and bead-like SiO2 nanowires.After heat-treated at 1300℃,the macroscopic size of SNM does not change significantly,and the interlocked structure is still maintained.Furthermore,SNM still maintains excellent mechanical properties,with tensile strength as high as 0.26 MPa.This work provides a facile method for fabricating excellent thermal insulating and fire-retardant ceramic membranes,showing prospective application prospects in the era of thermal insulating materials. 展开更多
关键词 Silicon nitride nanowires Thermal insulation Fire-resistance High-temperature resistance
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Joint position optimization,user association,and resource allocation for load balancing in UAV-assisted wireless networks 认领 引用 被引量：1
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作者 Daosen Zhai Huan Li +2 位作者 Xiao Tang Ruonan Zhang Haotong Cao 《Digital Communications and Networks》 SCIE CSCD 2024年第1期25-37,共13页
Unbalanced traffic distribution in cellular networks results in congestion and degrades spectrum efficiency.To tackle this problem,we propose an Unmanned Aerial Vehicle(UAV)-assisted wireless network in which the UAV ... Unbalanced traffic distribution in cellular networks results in congestion and degrades spectrum efficiency.To tackle this problem,we propose an Unmanned Aerial Vehicle(UAV)-assisted wireless network in which the UAV acts as an aerial relay to divert some traffic from the overloaded cell to its adjacent underloaded cell.To fully exploit its potential,we jointly optimize the UAV position,user association,spectrum allocation,and power allocation to maximize the sum-log-rate of all users in two adjacent cells.To tackle the complicated joint optimization problem,we first design a genetic-based algorithm to optimize the UAV position.Then,we simplify the problem by theoretical analysis and devise a low-complexity algorithm according to the branch-and-bound method,so as to obtain the optimal user association and spectrum allocation schemes.We further propose an iterative power allocation algorithm based on the sequential convex approximation theory.The simulation results indicate that the proposed UAV-assisted wireless network is superior to the terrestrial network in both utility and throughput,and the proposed algorithms can substantially improve the network performance in comparison with the other schemes. 展开更多
关键词 Load balance Unmanned aerial vehicle Userassociation Resource management
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Energy-efficient data collection for UAV-assisted IoT: Joint trajectory and resource optimization 认领 引用 被引量：7
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作者 Xiao TANG Wei WANG +1 位作者 Hongliang HE Ruonan ZHANG 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2022年第9期95-105,共11页
Internet of Things(IoT) can be conveniently deployed while empowering various applications, where the IoT nodes can form clusters to finish certain missions collectively. As energyefficient operations are critical to ... Internet of Things(IoT) can be conveniently deployed while empowering various applications, where the IoT nodes can form clusters to finish certain missions collectively. As energyefficient operations are critical to prolong the lifetime of the energy-constrained IoT devices, the Unmanned Aerial Vehicle(UAV) can be dispatched to geographically approach the IoT clusters towards energy-efficient IoT transmissions. This paper intends to maximize the system energy efficiency by considering both the IoT transmission energy and UAV propulsion energy, where the UAV trajectory and IoT communication resources are jointly optimized. By applying largesystem analysis and Dinkelbach method, the original fractional optimization is approximated and reformulated in the form of subtraction, and further a block coordinate descent framework is employed to update the UAV trajectory and IoT communication resources iteratively. Extensive simulation results are provided to corroborate the effectiveness of the proposed method. 展开更多
关键词 Block coordinate descent Data collection Dinkelbach method Energy efficiency Internet of Things(IoT) Unmanned aerial vehicle
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华北雨季降水年代际变化与水汽输送的联系 认领 引用 被引量：22
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作者 崔童 张若楠 +1 位作者 郝立生 孙丞虎 《大气科学》 CSCD 北大核心 2022年第4期903-920,共18页
本文基于1961~2018年华北地区均一化逐日降水资料和ECMWF(欧洲中期天气预报中心)ERA5全球再分析环流资料,采用一种综合考虑降水量和西太平洋副热带高压脊线影响的雨季监测标准,计算了华北雨季起讫日期和降水量,在此基础上讨论了华北雨... 本文基于1961~2018年华北地区均一化逐日降水资料和ECMWF(欧洲中期天气预报中心)ERA5全球再分析环流资料,采用一种综合考虑降水量和西太平洋副热带高压脊线影响的雨季监测标准,计算了华北雨季起讫日期和降水量,在此基础上讨论了华北雨季季节内进程的水汽输送特征。重点分析了降水量与水汽收支的年代际变化关系,揭示了水汽输送的时空变化规律及其对华北雨季降水的影响。研究结果表明:(1)华北雨季每年的起讫日期不同,从而每年雨季发生时段和季节内进程不同。(2)降水的形成与水汽输送及其辐合密切相关,有四个水汽通道维持华北雨季降水,即印度季风水汽、东亚季风水汽、110°E~120°E之间越赤道气流向北的水汽输送和40°N附近中纬度西风带水汽。(3)华北雨季降水和净水汽收支具有相似的年代际变化特征,分别在1977、1987、1999年发生突变,总体呈现“减—增—减”的阶段性变化趋势,两者位相转变相关性很强。(4)水汽输送的强弱和到达华北时间的早晚均对雨季降水多寡有重要影响。华北多雨年代与少雨年代水汽通量有明显的差异,主要表现在:在多雨年代,西北太平洋为反气旋式环流异常,偏南水汽强盛,并且与中高纬西风带异常偏西水汽汇聚于华北,华北地区水汽辐合偏强;考虑季节内进程,水汽到达华北的时间早、强度大,停留时间长、辐合强,减弱的时间晚;而在少雨年代,我国东北地区、朝鲜半岛及日本海附近为气旋式环流异常,华北地区由南向北的水汽输送偏弱,水汽辐散明显加强;季节内进程表现出与多雨年代相反的特征。(5)考虑华北地区四个边界的水汽收支,南边界和西边界有最大、次大水汽输入,二者的年代际变化是影响雨季降水年代际变化的重要因素。在多雨年代,南边界和西边界水汽净输入很强,但北边界的输出也很强;在少雨年代,南边界和西边界水汽净输入很弱,但北边界转为输入,这是区别于多雨年代的重要特征。 展开更多
关键词 华北雨季 水汽输送 水汽收支 年代际变化
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基于时序信道预测与展开图神经网络的星间安全空中计算方法 认领 引用
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作者 唐晓 惠通 +3 位作者 杜清河 刘金鑫 张若南 沈超 《中国科学：信息科学》 CAS CSCD 北大核心 2026年第3期684-703,共20页
低地球轨道(low Earth orbit,LEO)卫星作为6G空天地一体化网络的关键支撑,面临着海量数据高效汇聚与安全保障的双重挑战.空中计算(over-the-air computation,AirComp)利用无线波形叠加实现计算与传输融合,虽然能显著提升通信和计算效率... 低地球轨道(low Earth orbit,LEO)卫星作为6G空天地一体化网络的关键支撑,面临着海量数据高效汇聚与安全保障的双重挑战.空中计算(over-the-air computation,AirComp)利用无线波形叠加实现计算与传输融合,虽然能显著提升通信和计算效率,但其无线广播特性使其极易遭受窃听.针对上述问题,面向窃听威胁下的高动态星间链路,解耦信道预测和安全计算决策,提出一种基于深度学习的安全AirComp框架.首先,基于卫星轨道动力学先验数据,建立物理驱动的信道演化模型.设计基于时序Transformer的信道预测网络,采用残差学习范式,从历史观测中捕捉信道物理量的非线性演化轨迹,实现高精度星间信道预测.在此基础上,提出基于深度展开图神经网络(graph neural network,GNN)的AirComp策略求解器,将迭代优化算法映射为多层展开神经网络,通过GNN中的消息传递建模不同卫星节点间的交互与协同,高效生成抗窃听的安全AirComp波束成形策略.仿真结果表明,所提方案在信道参数预测上比传统方法显著降低预测误差,并且在多种网络配置条件下,均能实现接近上界的安全AirComp速率,显著优于现有启发式基线AirComp方案. 展开更多
关键词 低地球轨道卫星 空中计算 信道预测 图神经网络 Transformer
Trophoblast-derived exosomes containing PD-L1 may have protective effects on preeclampsia by regulating Tregs 认领 引用
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作者 Jianliu Wang Ruonan Zhang 《Medical Review》 2025年第5期425-428,共4页
Once maternal-fetal immune tolerance is broken,pregnancy complications such as preeclampsia(PE)will occur.Regulatory T cells(Tregs)as unique immunosuppressive cells,play an important role in this whole process.Program... Once maternal-fetal immune tolerance is broken,pregnancy complications such as preeclampsia(PE)will occur.Regulatory T cells(Tregs)as unique immunosuppressive cells,play an important role in this whole process.Programmed cell death 1 ligand 1(PD-L1)is widely expressed in human placental trophoblasts,through binding with programmed cell death protein 1(PD-1)to maternal-fetal immunomodulation.Exosomes belong to extracellular membrane-bound microvesicles(EMV)that get more and more attention in signaling pathways and disease regulation.The role of Tregs in the development of PE and the role of PD-1/PD-L1 in regulating the function of Tregs have been studied,but the mechanism of trophoblastderived exosomes containing PD-L1 influences PE by mediating maternal-fetal interface immunity is still unclear.In this article,our specific hypothesis is that trophoblast-derived exosomes containing PD-L1 which may decrease in PE could regulate the proportion and differentiation of Tregs in the decidua.This mechanism of suppression must be further investigated as it may provide valuable clues to novel therapeutic design in the realm of PE research. 展开更多
关键词 exosomes PD-L1/PD-1 regulatory T cells preeclampsia immunomodulation
Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1 认领 引用 被引量：73
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作者 Na Kong Xiaying Chen +20 位作者 Jiao Feng Ting Duan Shuiping Liu Xueni Sun Peng Chen Ting Pan Lili Yan Ting Jin Yu Xiang Quan Gao Chengyong Wen Weirui Ma Wencheng Liu Mingming Zhang Zuyi Yang Wengang Wang Ruonan Zhang Bi Chen Tian Xie Xinbing Sui Wei Tao 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2021年第12期4045-4054,共10页
Ferroptosis is a non-apoptotic regulated cell death caused by iron accumulation and subsequent lipid peroxidation.Currently,the therapeutic role of ferroptosis on cancer is gaining increasing interest.Baicalin an acti... Ferroptosis is a non-apoptotic regulated cell death caused by iron accumulation and subsequent lipid peroxidation.Currently,the therapeutic role of ferroptosis on cancer is gaining increasing interest.Baicalin an active component in Scutellaria baicalensis Georgi with anticancer potential various cancer types;however,the effects of baicalein on bladder cancer and the underlying molecular mechanisms remain largely unknown.In the study,we investigated the effect of baicalin on bladder cancer cells5637 and KU-19-19.As a result,we show baicalin exerted its anticancer activity by inducing apoptosis and cell death in bladder cancer cells.Subsequently,we for the first time demonstrate baicalin-induced ferroptotic cell death in vitro and in vivo,accompanied by reactive oxygen species(ROS) accumulation and intracellular chelate iron enrichment.The ferroptosis inhibitor deferoxamine but not necrostatin-1,chloroquine(CQ),N-acetyl-L-cysteine,L-glutathione reduced,or carbobenzoxy-valyl-alanyl-aspartyl-[O-methyl]-fluoromethylketone(Z-VAD-FMK) rescued baicalin-induced cell death,indicating ferroptosis contributed to baicalin-induced cell death.Mechanistically,we show that ferritin heavy chain1(FTH1) was a key determinant for baicalin-induced ferroptosis.Overexpression of FTH1 abrogated the anticancer effects of baicalin in both 5637 and KU19-19 cells.Taken together,our data for the first time suggest that the natural product baicalin exerts its anticancer activity by inducing FTH1-dependent ferroptosis,which will hopefully provide a prospective compound for bladder cancer treatment. 展开更多
关键词 Baicalin Ferroptosis Bladder cancer FTH1 Deferoxamine
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Curcumenol triggered ferroptosis in lung cancer cells via lncRNA H19/miR-19b-3p/FTH1 axis 认领 引用 被引量：39
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作者 Ruonan Zhang Ting Pan +20 位作者 Yu Xiang Mingming Zhang Han Xie Zimao Liang Bi Chen Cong Xu Jing Wang Xingxing Huang Qianru Zhu Ziming Zhao Quan Gao Chengyong Wen Wencheng Liu Weirui Ma Jiao Feng Xueni Sun Ting Duan Elaine Lai-Han Leung Tian Xie Qibiao Wu Xinbing Sui 《Bioactive Materials》 SCIE CSCD 2022年第7期23-36,共14页
Curcumenol,an effective ingredient of Wenyujin,has been reported that exerted its antitumor potential in a few cancer types.However,the effect and molecular mechanism of curcumenol in lung cancer are largely unknown.H... Curcumenol,an effective ingredient of Wenyujin,has been reported that exerted its antitumor potential in a few cancer types.However,the effect and molecular mechanism of curcumenol in lung cancer are largely unknown.Here,we found that curcumenol induced cell death and suppressed cell proliferation in lung cancer cells.Next,we demonstrated that ferroptosis was the predominant method that contributed to curcumenol-induced cell death of lung cancer in vitro and vivo for the first time.Subsequently,using RNA sequencing,we found that the long non-coding RNA H19(lncRNA H19)was significantly downregulated in lung cancer cells treated with curcumenol,when compared to untreated controls.Overexpression of lncRNA H19 eliminated the anticancer effect of curcumenol,while lncRNA H19 knockdown promoted ferroptosis induced by curcumenol treatment.Mechanistically,we showed that lncRNA H19 functioned as a competing endogenous RNA to bind to miR-19b-3p,thereby enhanced the transcription activity of its endogenous target,ferritin heavy chain 1(FTH1),a marker of ferroptosis.In conclusion,our data show that the natural product curcumenol exerted its antitumor effects on lung cancer by triggering ferroptosis,and the lncRNA H19/miR-19b-3p/FTH1 axis plays an essential role in curcumenol-induced ferroptotic cell death.Therefore,our findings will hopefully provide a valuable drug for treating lung cancer patients. 展开更多
关键词 Curcumenol Ferroptosis Lung cancer lncRNA H19 miRNA-19b-3p FTH1
Erianin,a novel dibenzyl compound in Dendrobium extract,inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis 认领 引用 被引量：97
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作者 Peng Chen Qibiao Wu +32 位作者 Jiao Feng Lili Yan Yitian Sun Shuiping Liu Yu Xiang Mingming Zhang Ting Pan Xiaying Chen Ting Duan Lijuan Zhai Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Xuemeng Han Yicong Li Liuxi Chen Ying Liu Xingxing Huang Ting Jin Wenzheng Zhang Hong Luo Xiaohui Chen Yongqiang Li Qiujie Li Guohua Li Qin Zhang Lvjia Zhuo Zuyi Yang Huifen Tang Tian Xie Xiaoping Ouyang Xinbing Sui 《Signal Transduction and Targeted Therapy》 SCIE CSCD 2020年第1期1882-1892,共11页
Ferroptosis,a novel form of programmed cell death,is characterized by iron-dependent lipid peroxidation and has been shown to be involved in multiple diseases,including cancer.Stimulating ferroptosis in cancer cells m... Ferroptosis,a novel form of programmed cell death,is characterized by iron-dependent lipid peroxidation and has been shown to be involved in multiple diseases,including cancer.Stimulating ferroptosis in cancer cells may be a potential strategy for cancer therapy.Therefore,ferroptosis-inducing drugs are attracting more attention for cancer treatment.Here,we showed that erianin,a natural product isolated from Dendrobium chrysotoxum Lindl,exerted its anticancer activity by inducing cell death and inhibiting cell migration in lung cancer cells.Subsequently,we demonstrated for the first time that erianin induced ferroptotic cell death in lung cancer cells,which was accompanied by ROS accumulation,lipid peroxidation,and GSH depletion.The ferroptosis inhibitors Fer-1 and Lip-1 but not Z-VAD-FMK,CQ,or necrostatin-1 rescued erianin-induced cell death,indicating that ferroptosis contributed to erianin-induced cell death.Furthermore,we demonstrated that Ca2+/CaM signaling was a critical mediator of erianin-induced ferroptosis and that blockade of this signaling significantly rescued cell death induced by erianin treatment by suppressing ferroptosis.Taken together,our data suggest that the natural product erianin exerts its anticancer effects by inducing Ca2+/CaMdependent ferroptosis and inhibiting cell migration,and erianin will hopefully serve as a prospective compound for lung cancer treatment. 展开更多
关键词 peroxidation lung drugs
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Ultrafast and real-time physical random bit extraction with all-optical quantization 认领 引用 被引量：10
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作者 Ya Guo Qiang Cai +4 位作者 Pu Li Ruonan Zhang Bingjie Xu K.Alan Shore Yuncai Wang 《Advanced Photonics》 SCIE EI CAS CSCD 2022年第3期83-89,共7页
Optical chaos generated by perturbing semiconductor lasers has been viewed,over recent decades,as an excellent entropy source for fast physical random bit generation(RBG)owing to its high bandwidth and large random fl... Optical chaos generated by perturbing semiconductor lasers has been viewed,over recent decades,as an excellent entropy source for fast physical random bit generation(RBG)owing to its high bandwidth and large random fluctuations.However,most optical-chaos-based random bit generators perform their quantization process in the electrical domain using electrical analog-to-digital converters,so their real-time rates in a single channel are severely limited at the level of Gb/s due to the electronic bottleneck.Here,we propose and experimentally demonstrate an all-optical method for RBG where chaotic pulses are quantized into a physical random bit stream in the all-optical domain by means of a length of highly nonlinear fiber.In our proof-of-concept experiment,a 10-Gb/s random bit stream is successfully generated on-line using our method.Note that the single-channel real-time rate is limited only by the chaos bandwidth.Considering that the Kerr nonlinearity of silica fiber with an ultrafast response of few femtoseconds is exploited for composing the key part of quantizing laser chaos,this scheme thus may operate potentially at much higher real-time rates than 100 Gb/s provided that a chaotic entropy source of sufficient bandwidth is available. 展开更多
关键词 chaos random number generation semiconductor lasers optical signal processing.
PCDH17 increases the sensitivity of colorectal cancer to 5-fluorouracil treatment by inducing apoptosis and autophagic cell death 认领 引用 被引量：11
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作者 Shuiping Liu Haoming Lin +31 位作者 Da Wang Qiang Li Hong Luo Guoxiong Li Xiaohui Chen Yongqiang Li Peng Chen Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Mingming Zhang Xuemeng Han Qiujie Li Liuxi Chen Ying Liu Xiaying Chen Guohua Li Yu Xiang Ting Duan Jiao Feng Jianshu Lou Xingxing Huang Qin Zhang Ting Pan Lili Yan Ting Jin Wenzheng Zhang Lvjia Zhuo Yitian Sun Tian Xie Xinbing Sui 《Signal Transduction and Targeted Therapy》 SCIE CSCD 2019年第1期176-185,共10页
5-Fluorouracil(5-FU)is known as a first-line chemotherapeutic agent against colorectal cancer(CRC),but drug resistance occurs frequently and significantly limits its clinical success.Our previous study showed that the... 5-Fluorouracil(5-FU)is known as a first-line chemotherapeutic agent against colorectal cancer(CRC),but drug resistance occurs frequently and significantly limits its clinical success.Our previous study showed that the protocadherin 17(PCDH17)gene was frequently methylated and functioned as a tumor suppressor in CRC.However,the relationship between PCDH17 and 5-FU resistance in CRC remains unclear.Here,we revealed that PCDH17 was more highly expressed in 5-FU-sensitive CRC tissues than in 5-FU-resistant CRC tissues,and high expression of PCDH17 was correlated with high BECN1 expression.Moreover,this expression profile contributed to superior prognosis and increased survival in CRC patients.Restoring PCDH17 expression augmented the 5-FU sensitivity of CRC in vitro and in vivo by promoting apoptosis and autophagic cell death.Furthermore,autophagy played a dominant role in PCDH17-induced cell death,as an autophagy inhibitor blocked cell death to a greater extent than the pancaspase inhibitor Z-VAD-FMK.PCDH17 inhibition by siRNA decreased the autophagy response and 5-FU sensitivity.Mechanistically,we showed that c-Jun NH2-terminal kinase(JNK)activation was a key determinant in PCDH17-induced autophagy.The compound SP600125,an inhibitor of JNK,suppressed autophagy and 5-FU-induced cell death in PCDH17-reexpressing CRC cells.Taken together,our findings suggest for the first time that PCDH17 increases the sensitivity of CRC to 5-FU treatment by inducing apoptosis and JNK-dependent autophagic cell death.PCDH17 may be a potential prognostic marker for predicting 5-FU sensitivity in CRC patients. 展开更多
关键词 death treatment apoptosis
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