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Operational challenges and mitigation strategies in preparing malaria quality control panels 认领 引用
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作者 Naseem Ahmed Supriya Sharma +2 位作者 Piyush Choudhary Anupkumar Anvikar Praveen Kumar Bharti 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2026年第7期285-287,共3页
Over the past decades,rapid diagnostic tests(RDTs)have become the most widely deployed diagnostic tool,enabling timely treatment in resource-limited and remote settings[1].Their reliability,however,depends on rigorous... Over the past decades,rapid diagnostic tests(RDTs)have become the most widely deployed diagnostic tool,enabling timely treatment in resource-limited and remote settings[1].Their reliability,however,depends on rigorous quality assurance frameworks,with the World Health Organization(WHO)-endorsed quality control panels serving as the cornerstone for monitoring RDT performance and ensuring diagnostic fidelity across diverse epidemiological landscapes[2].Quality control panels are standardized,parasite-based reference materials used to evaluate antigen detection by RDTs under controlled conditions.They play an essential role in detecting lot-to-lot variations,guiding procurement decisions,and safeguarding programmatic confidence in RDTs[3].Despite this centrality,the practical and operational realities of quality control panel preparation in malaria-endemic regions remain underexplored. 展开更多
关键词 diagnostic tests rdts mitigation strategies malaria quality control panels quality assurance frameworkswith quality control panels control panels operational challenges timely treatment
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Internal hernia as a rare cause of small bowel obstruction:An insight from 13 years of experience 认领 引用 被引量：1
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作者 Payal Kaw Anu Behari +2 位作者 Supriya Sharma Ashok Kumar Rajneesh K Singh 《World Journal of Clinical Cases》 2025年第7期21-27,共7页
BACKGROUND Internal hernia(IH)is a rare culprit of small bowel obstruction(SBO)with an incidence of<1%.It poses a considerable diagnostic challenge requiring a high index of suspicion to prevent misdiagnosis,improp... BACKGROUND Internal hernia(IH)is a rare culprit of small bowel obstruction(SBO)with an incidence of<1%.It poses a considerable diagnostic challenge requiring a high index of suspicion to prevent misdiagnosis,improper treatment,and subsequent morbidity and mortality.AIM To determine the clinico-demographic profile,radiological and operative findings,and postoperative course of patients with IH and its association with SBO.METHODS Medical records of 586 patients with features of SBO presenting at a tertiary care centre at Lucknow,India between September 2010 and August 2023 were reviewed.RESULTS Out of 586 patients,7(1.2%)were diagnosed with IH.Among these,4 had congenital IH and 3 had acquired IH.The male-to-female ratio was 4:3.The median age at presentation was 32 years.Contrast-enhanced computed tomography(CECT)was the most reliable investigation for preoperative identification,demonstrating mesenteric whirling and clumped-up bowel loops.Left paraduodenal hernia and transmesenteric hernia occurred with an equal frequency(approximately 43%each).Intraoperatively,one patient was found to have bowel ischemia and one had associated malrotation of gut.During follow-up,no recurrences were reported.CONCLUSION IH,being a rare cause,must be considered as a differential diagnosis for SBO,especially in young patients in their 30s or with unexplained abdominal pain or discomfort post-surgery.A rapid imaging evaluation,preferably with CECT,is necessary to aid in an early diagnosis and prompt intervention,thereby reducing financial burden related to unnecessary investigations and preventing the morbidity and mortality associated with closed-loop obstruction and strangulation of the bowel. 展开更多
关键词 Paraduodenal hernia Internal hernia Mesenteric whirling Bowel obstruction Computed tomography
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Detection of plasmid-mediated mcr-1 gene in multidrug-resistant Escherichia coli from clinical specimens at a tertiary hospital in Nepal 认领 引用
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作者 Chetana Dahal Sanjib Adhikari +7 位作者 Ramesh Sharma Regmi Sanjeep Sapkota Nabaraj Adhikari Supriya Sharma Megha Raj Banjara Bimal Sharma Chalise Prakash Ghimire Komal Raj Rijal 《Infectious Diseases & Immunity》 CSCD 2025年第2期112-119,共8页
Background:The emergence of antibiotic resistance,particularly plasmid-mediated colistin resistance,poses a critical threat to global public health,given colistin’s role as a last-resort antibiotic for treating multi... Background:The emergence of antibiotic resistance,particularly plasmid-mediated colistin resistance,poses a critical threat to global public health,given colistin’s role as a last-resort antibiotic for treating multidrug-resistant(MDR)bacterial infections.Despite its significance,data on colistin resistance and the prevalence of mobile colistin resistance(mcr)genes in Nepal are scarce.This study aims to investigate the occurrence of plasmid-mediated mobilized colistin resistance genes mcr-1 and mcr-2 in MDR Escherichia coli isolates from clinical specimens,highlighting the burden of resistance and its clinical implications in Nepalese context.Methods:A hospital-based cross-sectional study was conducted at Sukraraj Tropical Infectious Disease Hospital in Kathmandu from March to August 2022.A total of 1358 clinical specimens were processed using standard microbiological techniques.Antibiotic susceptibility testing followed the Kirby-Bauer disk diffusion method per the 2016 Clinical and Laboratory Standards Institute guidelines.The minimum inhibitory concentration(MIC)for colistin was determined via agar dilution method.Colistin-resistant strains were further investigated for the detection of mcr-1 and mcr-2 genes using endpoint polymerase chain reaction.Results:A total of 86 E.coli isolates were recovered with a prevalence rate of 6.3%(86/1358).Higher growth rates of E.coli were observed among females(9.0%,56/620),individuals aged 46-60 years(8.5%,23/271),and in pus samples(3 out of 7).Majorities of the isolates exhibited high resistance rates towards beta-lactam antibiotics and cotrimoxazole,with 81.4%(70/86)classified as MDR.The MIC of colistin was≥4μg/mL in 7 isolates.The prevalence of extended-spectrum beta-lactamase(ESBL)-,metallo-beta-lactamase(MBL)-,and klebsiella pneumoniae carbapenemases-producing isolates was 40.7%(35/86),14.0%(12/86),and 1.2%(1/86),respectively.The mcr-1 gene was detected in 5 colistin-resistant isolates,while mcr-2 was not identified.Notably,all ESBL-and MBL-producing isolates were also MDR,with higher proportions of ESBL-producing(4 out of 5)and MBL-producing(1 out of 5)strains among those harboring the mcr-1 gene.Conclusions:This study highlights a concerning prevalence of mcr-1-mediated colistin resistance in E.coli isolates,compounded by co-resistance to other critical antibiotics such as beta-lactams and carbapenems.The findings underscore the urgent need for enhanced surveillance,antimicrobial stewardship,and research into colistin resistance mechanisms for preventing further escalation of the resistance burden. 展开更多
关键词 Drug resistance,multi Colistin resistance Escherichia coli Mobilized colistin resistant(mcr-1 and mcr-2)gene
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