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Gamma-type immunoglobulin enhances phagocytosis of amyloid-beta fibrils by microglia 认领 引用
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作者 Tian Zhou Yue Zhong +10 位作者 Shoujun Yu Ruibing Sun Zhenwei Zhang Xiaoyan Du Simon Ming-Yuen Lee Zhitong Chen Weiming Tian Yuxiao Lai Bing Song Yiming Zheng Zhen Xu 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第8期3668-3676,共9页
The peripheral immune system has emerged as a regulator of neurodegenerative diseases such as Alzheimer’s disease.Microglia are resident immune cells in the brain that may orchestrate communication between the centra... The peripheral immune system has emerged as a regulator of neurodegenerative diseases such as Alzheimer’s disease.Microglia are resident immune cells in the brain that may orchestrate communication between the central nervous system and peripheral immune system,though the mechanisms are unclear.Here,we found that gamma-type immunoglobulin,a product originating from peripheral blood B cells,localized in the brain parenchyma of multiple mouse models with amyloid pathology,and was enriched on microglia but not on other brain cell types.Further experiments showed that gamma-type immunoglobulin bound to microglial cell membranes and led to diverse transcriptomic changes,including upregulation of pathways related to phagocytosis and immunity.Functional assays demonstrated that gamma-type immunoglobulin enhanced microglial phagocytic capacity for amyloid-beta fibrils via its Fc fragment,but not Fab fragment,fragment.Our data indicate that microglia,when exposed to gamma-type immunoglobulin,exhibit an enhanced capacity for clearing amyloid-beta fibrils,potentially via the gamma-type immunoglobulin Fc fragment signaling pathway.This suggests that parenchymal gamma-type immunoglobulin should be further investigated to determine whether it may play a beneficial role against Alzheimer’s disease by enhancing microglial function. 展开更多
关键词 adaptive immunity Alzheimer’s disease amyloid-beta B cell blood-brain barrier cell membrane Fc fragment gamma-type immunoglobulin microglia phagocytosis
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NLRP3 inflammasome and gut microbiota–brain axis:A new perspective on white matter injury after intracerebral hemorrhage 认领 引用 被引量：3
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作者 Xiaoxi Cai Xinhong Cai +4 位作者 Quanhua Xie Xueqi Xiao Tong Li Tian Zhou Haitao Sun 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第1期62-80,共19页
Intracerebral hemorrhage is the most dangerous subtype of stroke,characterized by high mortality and morbidity rates,and frequently leads to significant secondary white matter injury.In recent decades,studies have rev... Intracerebral hemorrhage is the most dangerous subtype of stroke,characterized by high mortality and morbidity rates,and frequently leads to significant secondary white matter injury.In recent decades,studies have revealed that gut microbiota can communicate bidirectionally with the brain through the gut microbiota–brain axis.This axis indicates that gut microbiota is closely related to the development and prognosis of intracerebral hemorrhage and its associated secondary white matter injury.The NACHT,LRR,and pyrin domain-containing protein 3(NLRP3)inflammasome plays a crucial role in this context.This review summarizes the dysbiosis of gut microbiota following intracerebral hemorrhage and explores the mechanisms by which this imbalance may promote the activation of the NLRP3 inflammasome.These mechanisms include metabolic pathways(involving short-chain fatty acids,lipopolysaccharides,lactic acid,bile acids,trimethylamine-N-oxide,and tryptophan),neural pathways(such as the vagus nerve and sympathetic nerve),and immune pathways(involving microglia and T cells).We then discuss the relationship between the activated NLRP3 inflammasome and secondary white matter injury after intracerebral hemorrhage.The activation of the NLRP3 inflammasome can exacerbate secondary white matter injury by disrupting the blood–brain barrier,inducing neuroinflammation,and interfering with nerve regeneration.Finally,we outline potential treatment strategies for intracerebral hemorrhage and its secondary white matter injury.Our review highlights the critical role of the gut microbiota–brain axis and the NLRP3 inflammasome in white matter injury following intracerebral hemorrhage,paving the way for exploring potential therapeutic approaches. 展开更多
关键词 gut microbiota gut microbiota–brain axis immune intracerebral hemorrhage neuroinflammation NLRP3 protein stroke therapeutics white matter injury
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Microstructure evolution and mechanical properties of spray-formed 7055 Al alloy subjected to cryogenic rolling 认领 引用
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作者 Tian ZHOU Yang-wei WANG +5 位作者 Jia-wei BAO Muhammad Abubaker KHAN Ping-luo ZHAO Rui AN Hao ZHANG Mohamed A.AFIFI 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2026年第2期386-400,共15页
Cryogenic rolling impacts on microstructure and mechanical properties of spray-formed 7055(SF-7055)Al alloy were investigated.Results show that with the increase of the reduction from 20%to 80%,the grain of cryogenic ... Cryogenic rolling impacts on microstructure and mechanical properties of spray-formed 7055(SF-7055)Al alloy were investigated.Results show that with the increase of the reduction from 20%to 80%,the grain of cryogenic rolled SF-7055 Al alloy is elongated to form a fiber texture.Numerous proliferating dislocations in the microstructure accumulate into dislocation walls and cells,and eventually form subgrains.These subgrain boundaries divide the original grain,thereby reducing the grain size.Under severe deformation conditions,they even enable the formation of nanograins.Meanwhile,the Cu-rich precipitates in the matrix are also broken and refined under the action of large rolling stress.In the process of cryogenic rolling,the tensile strength and hardness of SF-7055 Al alloy gradually increase,while the plasticity decreases.Moreover,the fracture morphology of cryogenic rolled SF-7055 Al alloy gradually transforms to the ductile and quasi-cleavage hybrid fracture characteristics with increased reduction. 展开更多
关键词 spray-formed Al alloy cryogenic rolling microstructure mechanical properties nanograins
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GPX4 Defines an Immune-Cold Phenotype and Poor Prognosis in Resected Lung Adenocarcinoma 认领 引用
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作者 Ganxin Wang Zhongan Liu +9 位作者 Tian Zhou Boting Yang Jiaqin Chen Jing Chen Kai Huang Yunqing Xu Quan Tang Xiangqian Yin Guangqin Xiao Sijia Zhang 《Oncology Research》 SCIE 2026年第8期566-589,共24页
Objectives:Ferroptosis resistance may contribute to tumor progression and immune escape.This study evaluated the prognostic and immunological significance of glutathione peroxidase 4(GPX4),a core ferroptosissuppressiv... Objectives:Ferroptosis resistance may contribute to tumor progression and immune escape.This study evaluated the prognostic and immunological significance of glutathione peroxidase 4(GPX4),a core ferroptosissuppressive enzyme,in surgically resected lung adenocarcinoma.Methods:We retrospectively analyzed 104 patients with primary lung adenocarcinoma who underwent curative resection.GPX4 protein expression was assessed by immunohistochemistry(IHC)using the histological score(H-score),and patients were classified as GPX4-low(n=54)or GPX4-high(n=50).Intratumoral immune contexture was quantified using CD3,CD4,CD8,CD68,programmed cell death protein 1(PD-1),and programmed death-ligand 1(PD-L1)staining.Disease-free survival(DFS)and overall survival(OS)were analyzed using Cox regression.Cutoff sensitivity analyses,category consolidation,ridge-penalized Cox regression,events-per-variable assessment,bootstrap internal validation,and interobserver reproducibility testing were performed to strengthen statistical robustness.Results:GPX4-high tumors were associated with systemic inflammatory and immune-related features,including elevated fibrinogen(p=0.015),lower lymphocyte-to-monocyte ratio(p=0.003),and altered aspartate aminotransferase-to-alanine aminotransferase ratio(p=0.028).GPX4-high tumors showed reduced intratumoral CD3+,CD4+,CD8+,and CD68+immune-cell infiltration,together with increased PD-1 and PD-L1 expression,indicating an immune-cold yet checkpoint-enriched phenotype.After category consolidation and ridge-penalized multivariable adjustment,high GPX4 expression remained independently associated with worse DFS(HR,8.63;95%CI,2.99-24.91;p<0.001)and OS(HR,6.94;95%CI,2.44-19.74;p<0.001).GPX4-based prognostic models showed bias-corrected C-index values of 0.782 for DFS and 0.826 for OS,with calibration slopes of 0.964 and 0.937,respectively.Conclusions:High GPX4 expression identifies a clinically adverse,ferroptosis-resistant,immune-remodeled phenotype in resected lung adenocarcinoma.Integrating GPX4 with clinicopathological and inflammatory variables may improve postoperative risk stratification. 展开更多
关键词 Lung adenocarcinoma GPX4 tumor immune microenvironment PD-L1 nomogram
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CSF1R-dependent microglia depletion mitigates neuroinflammation and photoreceptor loss in MNU-induced retinal degeneration 认领 引用
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作者 Hong Zhou Biyan Ni +12 位作者 Tian Zhou Ziqi Yang Yang Zhou Jingpeng Li Minglu Ma Huaicheng Wang Peng An Qingbo Guo Xiaojing Lin Shiya Lin Huiyi Xu Xialin Liu Chang He 《Eye Science》 2026年第2期89-100,共12页
Background:Microglial activation is a hallmark of retinal neurodegeneration.However,whether microglia predominantly drive inflammatory damage or support tissue adaptation after acute photoreceptor injury remains uncle... Background:Microglial activation is a hallmark of retinal neurodegeneration.However,whether microglia predominantly drive inflammatory damage or support tissue adaptation after acute photoreceptor injury remains unclear.Resolving this issue is critical for defining therapeutic strategies.As colony-stimulating factor 1 receptor(CSF1R)signaling is essential for microglial survival,its pharmacological inhibition enables selective microglial depletion in vivo.Here,we used the CSF1R inhibitor PLX5622 in the N-methyl-N-nitrosourea(MNU)model to directly test the contribution of microglia to inflammation and photoreceptor degeneration.Methods:C57BL/6J mice received PLX5622 for 14 days before and throughout a 5-day MNU regimen.Retinal structure was assessed by fundus photography,optical coherence tomography(OCT),and hematoxylin and eosin(H&E)histology.Visual function was evaluated via electroretinography(ERG).Global transcriptomic alterations were profiled by RNA-seq,and selected inflammatory and complement mediators were assessed by Western blot.Results:PLX5622 treatment resulted in near-complete depletion of TMEM119+/Iba1+microglia in MNU-injured retinas.Microglia depletion was associated with reduced fundus white lesions,preserved outer nuclear layer(ONL)thickness and nuclei density,and significantly rescued ERG a-and b-wave amplitudes.Transcriptomic analysis further revealed broad attenuation of pro-inflammatory and innate immune pathways,accompanied by modulation of antioxidant responses,mitochondrial/metabolic alterations,neuron-related signaling,and macroglial activation-related programs.Consistently,Western blot analysis confirmed that MNU-induced upregulation of IL-1β,C3,and C1qa was markedly reduced following PLX5622 treatment.Conclusions:Pharmacological CSF1R inhibition leading to efficient retinal microglial depletion attenuated neuroinflammatory responses and preserved photoreceptor structure and visual function in acute toxic retinal degeneration.These findings indicate that microglial activation functions predominantly as a pathogenic amplifier rather than an adaptive response in this context,and identify CSF1R-dependent myeloid signaling as a key mechanistic driver of injury-associated retinal degeneration. 展开更多
关键词 microglia CSF1R inhibition retinal degeneration photoreceptor injury neuroinflammation
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基于隶属度分析的海风-火-储系统聚合优化方法 认领 引用
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作者 解大 田洲 +1 位作者 张宇 王宇川 《电力科学与技术学报》 CAS CSCD 北大核心 2026年第1期1-12,共12页
针对海风–火–储系统中的多能源协同优化问题,提出了一种基于隶属度分析的聚合优化方法。该方法通过对风电场、火电厂和储能系统的建模与优化,完成了资源的动态聚合与灵活调度。具体而言,采用笛卡尔积生成聚合体集合,引入约束条件对初... 针对海风–火–储系统中的多能源协同优化问题,提出了一种基于隶属度分析的聚合优化方法。该方法通过对风电场、火电厂和储能系统的建模与优化,完成了资源的动态聚合与灵活调度。具体而言,采用笛卡尔积生成聚合体集合,引入约束条件对初步聚合体进行筛选,并基于风电消纳率、经济效益和火电协同调频能力3个维度进行隶属度评估与综合优化分析。研究结果表明,通过优化后的聚合体配置,不仅能够显著降低系统运行成本,而且增强了火电调频能力的协同性。算例分析以中国浙江省海风–火–储资源为研究对象,验证了该方法的有效性,为大规模新能源消纳和系统优化运行提供了新的理论支持和技术路径。 展开更多
关键词 海风–火–储系统 隶属度分析 优化配置 多目标优化 经济效益评估
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AP2 transcription factor CsAIL6 negatively regulates citric acid accumulation in citrus fruits by interacting with a WD40 protein CsAN11 认领 引用
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作者 Han Han Yu-Jia Li +4 位作者 Shariq Mahmood Alam Tian Zhou Muhammad Abbas Khan Aye Myat Thu Yong-Zhong Liu 《Horticulture Research》 SCIE CSCD 2025年第4期189-198,共10页
Citric acid accumulation is an essential process in citrus fruits that determines fruit flavor and marketability.The MBW complex transcription factor genes,CsAN11,CsAN1,and CsPH4 play key roles in regulating citric ac... Citric acid accumulation is an essential process in citrus fruits that determines fruit flavor and marketability.The MBW complex transcription factor genes,CsAN11,CsAN1,and CsPH4 play key roles in regulating citric acid accumulation.Although how to regulate CsAN1 or CsPH4 was widely investigated,studies on the regulation of CsAN11 are scarce.In this study,we characterized the AP2/ERF(APETALA2/ethylene response factor)transcription factor gene CsAIL6,which is lowly expressed in high-acid citrus varieties and highly expressed in low-acid citrus varieties.Overexpressing CsAIL6 obviously decreased the citric acid content in citrus fruits,calli,or tomatoes,whereas silencing CsAIL6 significantly increased the fruit citric acid content.Additionally,transcript levels of CsAN11,CsAN1,and CsPH4 were significantly increased by silencing CsAIL6;only the CsAN11 transcript level was significantly decreased by overexpressing CsAIL6.Similarly,only the tomato AN11(SIAN11)transcript level in CsAIL6 stably overexpressing fruits was markedly lower than that in wild-type(WT)fruits.Further experiments revealed that overexpressing CsAN11 significantly increased the organic acid content but had no obvious influence on the CsAIL6 transcript level;in addition,CsAIL6 only interacts with CsAN11,rather than with CsAN1 and CsPH4 of the MBW complex.Taken together,our findings verified that CsAIL6 negatively regulates citric acid accumulation through directly interacting with the WD40 protein CsAN11,which provides a new mechanism for citric acid accumulation in fruits through the regulation of the MBW complex. 展开更多
关键词 citrus fruits AP ERF transcription factor regulate csan WD protein citric acid mbw complex transcription factor csail citric acid accumulation
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A Bionic Ripple Bamboo Based Solar Interface Evaporator for High Efficiency Seawater Desalination 认领 引用
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作者 Juan Li Hao Yao +3 位作者 Jieyao Su Nongchao Tan Tian Zhou Lei Shi 《Journal of Bionic Engineering》 SCIE EI CSCD 2025年第6期3095-3107,共13页
The solar interfacial evaporation has a broad application prospect in the fields of steam generation and seawater desalination to deal with the global shortage of fresh-water resources.Bamboo is a great material for s... The solar interfacial evaporation has a broad application prospect in the fields of steam generation and seawater desalination to deal with the global shortage of fresh-water resources.Bamboo is a great material for solar interface evaporators because of its low thermal conductivity and inherent micro-channel porous structure.In this paper,a novel bamboo-based solar interface evaporator with a bionic ripple wave surface structure has been proposed.The subsequent evaporation experiments have been conducted to investigate the salt resistance,stability and water absorption of the bionic ripple bamboo based solar interface evaporator.The results have exhibited that the bamboo's water absorption has been enhanced after carbonization modification.Besides,it should be pointed out that this bamboo-based evaporator’s evaporation rate has dropped during the prolonged simulated seawater evaporation experiment,yet it remained fairly consistent at approximately 1.626 kg·m-2·h-1.The appearance for this experimental phenomenon is the decrease of the floatability of the evaporator constricted by the stored water body absorbed by the evaporator and the deposition of NaCl crystals at the photothermal interface.Besides,compared with the plate-structure evaporator,the salt deposition in the evaporator equipped with the bionic ripple wave surface structure is greatly improved.In regard to its advantages in low cost,environmental friendliness,good salt tolerance and high evaporation rate,the bamboo-based solar interface evaporator with a bionic ripple wave surface structure can provide a potential solution to the global problem of fresh-water shortage. 展开更多
关键词 Photothermal interface evaporation Bamboo-based Ripple structure Evaporation rate
面向低轨卫星网络的概率广播路由协议研究 认领 引用
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作者 阎颖 王路辉 +1 位作者 田洲 张媛 《空间电子技术》 2026年第1期135-144,共10页
低轨卫星互联网作为实现星地全域无缝覆盖的核心支撑,凭借广域覆盖、低时延等突出优势,成为6G时代空天地一体化架构的关键组成部分。然而,随着低轨卫星数量的不断增长,为实现星间网络组网而传输的协议开销迅速增大,占用了越来越多的星... 低轨卫星互联网作为实现星地全域无缝覆盖的核心支撑,凭借广域覆盖、低时延等突出优势,成为6G时代空天地一体化架构的关键组成部分。然而,随着低轨卫星数量的不断增长,为实现星间网络组网而传输的协议开销迅速增大,占用了越来越多的星间传输资源,严重降低了星间业务的传输效率。因此,降低星间网络组网开销是大规模星间网络组网需要解决的重要问题之一。当前卫星网络组网主要受地面网络控制器的管理,组网中大量协议报文需要通过全网泛洪广播的方式进行传输。尽管泛洪广播法能够保障消息在复杂网络中可靠送达至目的卫星,但泛洪过程中会产生大量冗余消息,这严重制约了低轨卫星网络资源的利用效率。针对这一问题,本文提出了一种概率泛洪广播路由协议。该协议根据可低轨卫星在不同空间状态下的通信要求,选取适配的概率泛洪决策函数,并对函数参数进行优化,进而保证较低的系统开销。仿真结果显示,在特定的低轨卫星空间环境中,该路由算法相较于基准算法,最高可降低30%的系统开销。因此可认为,本文所提出的路由算法在减少广播过程中冗余消息方面,对6G空天地一体化网络的高效运行具有切实的实践价值。 展开更多
关键词 低轨卫星 概率泛洪机制 网络路由 广播优化
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气候变化下川西地区森林碳储量对森林管理措施和干扰的长期响应 认领 引用 被引量：11
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作者 邓诗宇 张明芳 +6 位作者 侯怡萍 余恩旭 李强 刘子佩 胡嘉毅 田洲 徐亚莉 《生态学报》 CAS CSCD 北大核心 2025年第1期210-226,共17页
评估气候变化下森林管理措施对森林碳储量的长期影响对我国碳中和目标达成具有重要意义。传统森林碳储量评价方法对气候变化、火灾等干扰以及森林经营管理措施等多重影响下森林生态系统长期演替过程刻画不足,难以有效揭示多种作用因素... 评估气候变化下森林管理措施对森林碳储量的长期影响对我国碳中和目标达成具有重要意义。传统森林碳储量评价方法对气候变化、火灾等干扰以及森林经营管理措施等多重影响下森林生态系统长期演替过程刻画不足,难以有效揭示多种作用因素对区域森林碳汇能力的长期综合影响。针对上述问题,以气候变化敏感区川西高山、亚高山地区为例,在探讨传统碳储量评价方法局限性的基础上,构建了考虑森林干扰的自然恢复和森林干扰⁃森林经营管理措施组合的人工恢复方案,结合森林景观生态模型LANDIS PRO和森林生态系统碳⁃水动态模型PnET⁃II模拟、预测了未来气候情景下(2020—2070年)自然恢复和不同人工恢复方案下区域森林地上碳储量及碳密度的时空动态,并通过对比筛选出提升固碳能力的最佳森林管理措施。结果表明,川西地区森林林龄趋于年轻化(平均林龄40a),具有巨大碳汇提升潜力。2020—2070年,自然恢复情景下研究区森林地上碳储量将由2020年的466.99Tg增加至2070年的780.96Tg,提高了67.23%。其中,以云杉、冷杉为主的成熟、过熟常绿针叶林是川西地区碳储量的主要贡献来源。但是自然恢复情景下川西地区森林平均碳密度在21世纪中后期停滞增长,甚至下降。而人工恢复情景下,碳密度变化趋势则有所不同。在多种森林干扰与经营管理措施组合方案中,当森林火灾干扰比例为0.01/10a和森林管理措施面积比例为0.02/10a时,川西地区森林地上碳储量提升最大且碳密度呈持续增加趋势。该情景下,2070年森林碳储量及碳密度分别将达到807.76Tg和33.33Mg/hm2,较2020年分别增加了72.97%和12.21%。2070年人工恢复情景下森林碳储量和碳密度较于自然恢复情景下分别高3.4%和8.5%。由此可见,通过人工恢复措施优化将有助于突破川西地区森林固碳能力的自然恢复瓶颈,提升区域森林生态系统对未来气候的适应能力,促进未来气候下区域森林碳储量的持续增长。 展开更多
关键词 气候变化 森林地上碳储量 森林恢复 森林管理措施 森林干扰 LANDIS PRO模型
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Metabolic pathway modulation by olanzapine:Multitarget approach for treating violent aggression in patients with schizophrenia 认领 引用 被引量：1
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作者 Yan-Ning Song Shuang Xia +14 位作者 Zhi Sun Yong-Chao Chen Lu Jiao Wen-Hua Wan Hong-Wei Zhang Xiao Guo Hua Guo Shou-Feng Jia Xiao-Xin Li Shi-Xian Cao Li-Bin Fu Meng-Meng Liu Tian Zhou Lv-Feng Zhang Qing-Quan Jia 《World Journal of Psychiatry》 SCIE 2025年第1期37-53,共17页
BACKGROUND The use of network pharmacology and blood metabolomics to study the patho-genesis of violent aggression in patients with schizophrenia and the related drug mechanisms of action provides new directions for r... BACKGROUND The use of network pharmacology and blood metabolomics to study the patho-genesis of violent aggression in patients with schizophrenia and the related drug mechanisms of action provides new directions for reducing the risk of violent aggression and optimizing treatment plans.AIM To explore the metabolic regulatory mechanism of olanzapine in treating patients with schizophrenia with a moderate to high risk of violent aggression.METHODS Metabolomic technology was used to screen differentially abundant metabolites in patients with schizophrenia with a moderate to high risk of violent aggression before and after olanzapine treatment,and the related metabolic pathways were identified.Network pharmacology was used to establish protein-protein interaction networks of the core targets of olanzapine.Gene Ontology functional analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were subsequently performed.RESULTS Compared with the healthy group,the patients with schizophrenia group presented significant changes in the levels of 24 metabolites related to the disruption of 9 metabolic pathways,among which the key pathways were the alanine,aspartate and glutamate metabolism and arginine biosynthesis pathways.After treatment with olanzapine,the levels of 10 differentially abundant metabolites were significantly reversed in patients with schizophrenia.Olanzapine effectively regulated six metabolic pathways,among which the key pathways were alanine,aspartate and glutamate metabolism and arginine biosynthesis pathways.Ten core targets of olanzapine were involved in several key pathways.CONCLUSION The metabolic pathways of alanine,aspartate,and glutamate metabolism and arginine biosynthesis are the key pathways involved in olanzapine treatment for aggressive schizophrenia. 展开更多
关键词 Schizophrenia Violent aggression Olanzapine Metabolomics Network pharmacology
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构建灾害风险图谱提高电力系统安全调度能力 认领 引用 被引量：2
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作者 解大 李子怡 +1 位作者 田洲 王凯 《上海交通大学学报》 EI CAS CSCD 北大核心 2025年第9期1338-1347,共10页
严重的地质灾害会导致大停电事故,从而影响电网的安全稳定运行.针对地质灾害对电网的影响,提出一种基于灾害风险图谱的电力系统安全调度策略.首先,构建多种灾害影响因子的灾害风险图谱,并将该图谱与输电线路的地理位置相结合,得到输电... 严重的地质灾害会导致大停电事故,从而影响电网的安全稳定运行.针对地质灾害对电网的影响,提出一种基于灾害风险图谱的电力系统安全调度策略.首先,构建多种灾害影响因子的灾害风险图谱,并将该图谱与输电线路的地理位置相结合,得到输电线路的危险情况;然后,建立电力系统运行风险模型,通过风险综合指标对电力系统的风险情况进行量化分析;最后,以新英格兰地区为例,采用粒子群算法构建发电机和灵活性资源的调节策略,并验证其有效性和可行性.结果表明,所提电力系统安全调度策略可以有效减少包括电力系统越限/重载风险在内的风险综合指标值,增强电网运行的安全性和稳定性. 展开更多
关键词 地质灾害 风险图谱 越限/重载风险 灵活性资源
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Metamaterials: Reshape and Rethink 认领 引用 被引量：8
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作者 Ruopeng Liu Chunlin Ji +1 位作者 Zhiya Zhao Tian Zhou 《Engineering》 SCIE EI CAS 2015年第2期179-184,共6页
Metamaterials are composite materials whose material properties(acoustic, electrical, magnetic, or optical, etc.) are determined by their constitutive structural materials, especially the unit cells. The development o... Metamaterials are composite materials whose material properties(acoustic, electrical, magnetic, or optical, etc.) are determined by their constitutive structural materials, especially the unit cells. The development of metamaterials continues to redefine the boundaries of materials science. In the field of electromagnetic research and beyond, these materials offer excellent design flexibility with their customized properties and their tunability under external stimuli. In this paper, we first provide a literature review of metamaterials with a focus on the technology and its evolution. We then discuss steps in the industrialization process and share our own experience. 展开更多
关键词 metamaterials metasurface smart structure metadevices industrialization
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Theory and practice of cancer“Green Therapy” 认领 引用 被引量：15
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作者 Kaiwen Hu Tian Zhou 《Journal of Traditional Chinese Medical Sciences》 CAS 2016年第4期201-205,共5页
Under the guidance of the theory of traditional Chinese medicine(TCM),the“Green Therapy”for tumors aims to“control”the condition,i.e.“When lethal treatments were adopted,they should be discontinued when six-tenth... Under the guidance of the theory of traditional Chinese medicine(TCM),the“Green Therapy”for tumors aims to“control”the condition,i.e.“When lethal treatments were adopted,they should be discontinued when six-tenths of the disease is eliminated;When treatments with moderate toxicity were chosen,they should be stopped when seven-tenths of the disease is eliminated;When treatments with mild toxicity were using,they should be discontinued when eight-tenths of the disease is eliminated;Even if using non-toxic treatments,they should be terminated when nine-tenths of the disease is wiped out..If the efficacy is below our expectation,we could repeat the treatments;But if go beyond the extent,healthy qi will be damaged and it will not be beneficial or even do harm to the repair capability of the body”,which underlines the end point of treatment,or“stop interventions when half of the disorder is gone”.Based on the Green Therapy theory,minimally invasive surgeries,TCM external treatments,natural medications and the biological target therapies are main approaches in our clinical cancer management.It differs from the modern treatment mode.The Green Therapy for cancers treats“patient’s quality of life”as our priority.This therapy system is particularly suitable for cancer patients who are aged and disqualified for or failed from classic anti-cancer treatments.This is a new trend of anti-cancer strategy characterized by effectiveness,minimally invasion,quick recovery,easy toleration and great sustainability. 展开更多
关键词 Green Therapy Malignant tumor Cancer Strategy Traditional Chinese medicine
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Models to Simulate Effective Coverage of Fire Station Based on Real-Time Travel Times 认领 引用 被引量：2
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作者 Sicheng Zhu Dingli Liu +2 位作者 Weijun Liu Ying Li Tian Zhou 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第4期483-513,共31页
In recent years,frequent fire disasters have led to enormous damage in China.Effective firefighting rescues can minimize the losses caused by fires.During the rescue processes,the travel time of fire trucks can be sev... In recent years,frequent fire disasters have led to enormous damage in China.Effective firefighting rescues can minimize the losses caused by fires.During the rescue processes,the travel time of fire trucks can be severely affected by traffic conditions,changing the effective coverage of fire stations.However,it is still challenging to determine the effective coverage of fire stations considering dynamic traffic conditions.This paper addresses this issue by combining the traveling time calculationmodelwith the effective coverage simulationmodel.In addition,it proposes a new index of total effective coverage area(TECA)based on the time-weighted average of the effective coverage area(ECA)to evaluate the urban fire services.It also selects China as the case study to validate the feasibility of the models,a fire station(FS-JX)in Changsha.FS-JX station and its surrounding 9,117 fire risk points are selected as the fire service supply and demand points,respectively.A total of 196 simulation scenarios throughout a consecutiveweek are analyzed.Eventually,1,933,815 sets of valid sample data are obtained.The results showed that the TECA of FS-JX is 3.27 km2,which is far below the standard requirement of 7.00 km2 due to the traffic conditions.The visualization results showed that three rivers around FS-JX interrupt the continuity of its effective coverage.The proposed method can provide data support to optimize the locations of fire stations by accurately and dynamically determining the effective coverage of fire stations. 展开更多
关键词 Fire services fire station effective coverage real-time traffic simulation
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The inhibition effect of Chlorpromazine against the β-lactam resistance of MRSA 认领 引用 被引量：1
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作者 Ryong Kong Ok-Hwa Kang +4 位作者 Yun-Soo Seo Su-Hyun Mun Tian Zhou Dong-Won Shin Dong-Yeul Kwon 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2016年第6期526-530,共5页
Objective:To investigate the gene related to β-lactam resistance and to confirm the mechanism about a synergy effect between CPZ and β-lactam antibiotics.Methods:To measure antibacterial activity,we performed a mini... Objective:To investigate the gene related to β-lactam resistance and to confirm the mechanism about a synergy effect between CPZ and β-lactam antibiotics.Methods:To measure antibacterial activity,we performed a minimum inhibitory concentration(MIC) and synergy test.Transmission electron microscopy(TEM) was used in morphological analysis.To analyze gene expression,we conducted reverse transcriptase polymerase chain reaction(PCR).Results:We confirmed a synergy effect between CPZ and β-lactam antibiotics.Furthermore,we observed that CPZ affect the cell envelope of MRS A by using TEM.At the gene level,CPZ reduced the expression of resistance genes.Conclusions:Through this result,we hypothesize that a decrease of resistance factor expressions was caused by CPZ because it disrupts the activity of a sensor protein located in the cell membrane. 展开更多
关键词 Chlorpromazine PBP2a β-lactamase mecA blaZ MRSA
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Adaptive probabilistic load forecasting for individual buildings 认领 引用
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作者 Chenxi Wang Dalin Qin +3 位作者 Qingsong Wen Tian Zhou Liang Sun Yi Wang 《iEnergy》 2022年第3期341-350,共10页
Building-level load forecasting has become essential with the support of fine-grained data collected by widely deployed smart meters.It acts as a basis for arranging distributed energy resources,implementing demand re... Building-level load forecasting has become essential with the support of fine-grained data collected by widely deployed smart meters.It acts as a basis for arranging distributed energy resources,implementing demand response,etc.Compared to aggre-gated-level load,the electric load of an individual building is more stochastic and thus spawns many probabilistic forecasting meth-ods.Many of them resort to artificial neural networks(ANN)to build forecasting models.However,a well-designed forecasting model for one building may not be suitable for others,and manually designing and tuning optimal forecasting models for various buildings are tedious and time-consuming.This paper proposes an adaptive probabilistic load forecasting model to automatically generate high-performance NN structures for different buildings and produce quantile forecasts for future loads.Specifically,we cascade the long short term memory(LSTM)layer with the adjusted Differential ArchiTecture Search(DARTS)cell and use the pinball loss function to guide the model during the improved model fitting process.A case study on an open dataset shows that our proposed model has superior performance and adaptivity over the state-of-the-art static neural network model.Besides,the improved fitting process of DARTS is proved to be more time-efficient than the original one. 展开更多
关键词 Probabilistic load forecasting long short-term memory(LSTM) Differentiable neural ARchiTecture Search(DARTS) building load forecasting.
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High efficient removal of HCN over porous CuO/CeO2 micro-nano spheres at lower temperature range 认领 引用 被引量：2
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作者 Zhihao Yi Jie Sun +4 位作者 Jigang Li Tian Zhou Shouping Wei Hongjia Xie Yulin Yang 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2021年第10期155-164,共10页
The porous CeO2 flowerlike micro-nano spheres based materials were prepared to remove HCN effectively at lower temperature range.The CeO2 and a serious of porous flowerlike ceria based materials loaded with metal spec... The porous CeO2 flowerlike micro-nano spheres based materials were prepared to remove HCN effectively at lower temperature range.The CeO2 and a serious of porous flowerlike ceria based materials loaded with metal species including Cu,Ag,Ni,Co and Fe were synthesized by hydrothermal method and precipitation method respectively.The physicochemical properties were probed by means of XRD,H2-TPR,BET,SEM and XPS.The removal ability for 130 mg·m﹣3 HCN over CuO/CeO2 showed the highest activity,the breakthrough time of which was more than 70 min at the condition of 30℃,120,000 h-1 and b 5%(volume)H2O,owe to a higher relative atomic ratio of oxygen vacancies and Oβ,the stronger interaction between metal particle and support,the optimum redox properties.The reaction mechanism was speculated by detecting the reaction products selectivity at different reaction temperature.It was shown that the reaction system for removal of HCN over CuO/CeO2 catalytic material involved chemisorption,catalytic hydrolysis,catalytic oxidation as well as NH3-SCR reactions. 展开更多
关键词 Rice(Oryza sativa L.) Saline-alkaline stress Abscisic acid(ABA) OsABA8ox1-kd Endogenous ABA levels
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Underwater Gas Leakage Flow Detection and Classification Based on Multibeam Forward-Looking Sonar 认领 引用 被引量：2
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作者 Yuanju Cao Chao Xu +3 位作者 Jianghui Li Tian Zhou Longyue Lin Baowei Chen 《哈尔滨工程大学学报（英文版）》 CSCD 2024年第3期674-687,共14页
The risk of gas leakage due to geological flaws in offshore carbon capture, utilization, and storage, as well as leakage from underwater oil or gas pipelines, highlights the need for underwater gas leakage monitoring ... The risk of gas leakage due to geological flaws in offshore carbon capture, utilization, and storage, as well as leakage from underwater oil or gas pipelines, highlights the need for underwater gas leakage monitoring technology. Remotely operated vehicles(ROVs) and autonomous underwater vehicles(AUVs) are equipped with high-resolution imaging sonar systems that have broad application potential in underwater gas and target detection tasks. However, some bubble clusters are relatively weak scatterers, so detecting and distinguishing them against the seabed reverberation in forward-looking sonar images are challenging. This study uses the dual-tree complex wavelet transform to extract the image features of multibeam forward-looking sonar. Underwater gas leakages with different flows are classified by combining deep learning theory. A pool experiment is designed to simulate gas leakage, where sonar images are obtained for further processing. Results demonstrate that this method can detect and classify underwater gas leakage streams with high classification accuracy. This performance indicates that the method can detect gas leakage from multibeam forward-looking sonar images and has the potential to predict gas leakage flow. 展开更多
关键词 Carbon capture utilization and storage(CCUS) Gas leakage Forward-looking sonar Dual-tree complex wavelet transform(DT-CWT) Deep learning
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Use of traditional Chinese medicine in the treatment of immune-related adverse events of cancer immunotherapy 认领 引用 被引量：2
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作者 Li Hou Liya Ju +6 位作者 Jing Wang Tian Zhou Yang Shen Jiaqi Chi Jean-Pierre Armand Anlong Xu Kaiwen Hu 《Journal of Traditional Chinese Medical Sciences》 CAS 2018年第4期323-327,共5页
Immune checkpoint inhibitors(ICPI)have shown considerable promise in the treatment of tumors.However,immune-related adverse events(irAEs)caused by ICPI have been reported in nearly every organ system.Whilst this repre... Immune checkpoint inhibitors(ICPI)have shown considerable promise in the treatment of tumors.However,immune-related adverse events(irAEs)caused by ICPI have been reported in nearly every organ system.Whilst this represents a new challenge in the field of cancer treatment,traditional Chinese medicine(TCM)provides benefits in the treatment of irAEs.This article reviews the studies of the treatment of immune-related gastrointestinal diseases and dermatosis with TCM and introduces the collaborative efforts between China and France in the implementation of TCM for the treatment of irAEs. 展开更多
关键词 Immune-related adverse events Traditional Chinese medicine Cancer immunotherapy Immune checkpoint inhibitors
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