Shear wave splitting(SWS)analysis has been widely employed for fracture characterization in both global seismology and seismic exploration.Two key SWS attributes—fast shear wave polarization and the time delay betwee...Shear wave splitting(SWS)analysis has been widely employed for fracture characterization in both global seismology and seismic exploration.Two key SWS attributes—fast shear wave polarization and the time delay between fast and slow shear waves—can be inverted from four-component seismic data(two horizontal sources and two horizontal receivers).These SWS attributes enable the characterization of subsurface fracture parameters,such as fracture strike and density.In this study,a nine-component vertical seismic profile(VSP)survey was acquired in the Sanhu Depression of the eastern Qaidam Basin,northwestern China.Preliminary analysis of the shear-wave source VSP data reveals two distinct SWS signatures at different depths,corresponding to two separate fractured layers.However,characterizing multiple fractured layers presents significant challenges,as the SWS attributes of deeper fractured layers are strongly influenced by those of overlying fractured formations.Existing approaches for predicting multi-layer fracture parameters are predominantly data-driven and are largely limited to qualitative analysis.To address these challenges,we propose a robust,rock-physics-model-guided method that enables the quantitative estimation of both the fracture strike and fracture density in multiple fractured laye rs.First,the parameters of the shallow fractu red layer are directly estimated from the SWS attributes.Then,synthetic VSP records of the deeper fractured layer are modeled by incorporating Hudson's theory and the reflectivity method.The fracture parameters of the deep fractured layer are inverted by minimizing the difference between the SWS attributes of synthetic records and those of the actual seismic data.A hierarchical search strategy(coarse-scale+refined-scale)is employed to accelerate convergence toward the optimal solution.This investigation provides a practical tool for quantitative characterization of subsurface formations with multiple fractured layers.展开更多
In the fields of reservoir fracture prediction and fracturing monitoring,shear-wave splitting analysis has exhibited notable technical advantages.Compared with compressional waves,it offers a more robust capability fo...In the fields of reservoir fracture prediction and fracturing monitoring,shear-wave splitting analysis has exhibited notable technical advantages.Compared with compressional waves,it offers a more robust capability for predicting the orientation and extent of fracture development systems or formation heterogeneity.In regions characterized by vertically or unidirectionally fractured thin interbedded formations,conventional shear-wave splitting analysis and correction methods based on the HTI(Horizontal Transverse Isotropy)medium model are inadequate.These methods fail to account for the increased propagation time difference between fast and slow shear-waves as they accumulate through layered media.This limitation arises because the subsurface medium in such scenarios is more accurately approximated by an orthotropic medium model.To address this challenge,shear-wave splitting analysis and correction methods based on orthotropic media have been developed and implemented.The method first determines the fracture orientation using established techniques,then separates the fast and slow shear-waves through wavefield rotation,and finally employs a matching algorithm to compute the instantaneous time difference between the fast and slow shear-waves.By introducing time-varying delay correction,this approach enables the accurate estimation of delay values that better reflect the actual properties of the subsurface medium.As a result,it enhances the precision of fracture detection in targeted formation intervals.The method has demonstrated excellent performance in both synthetic model and real-data applications.展开更多
The slow phase transition from formⅡto formⅠhas always been an important factor that restricts the processing and application of polybutene-1(PB-1).After extensive efforts,a set of effective methods for promoting th...The slow phase transition from formⅡto formⅠhas always been an important factor that restricts the processing and application of polybutene-1(PB-1).After extensive efforts,a set of effective methods for promoting the phase transition rate in PB-1 was established by adjusting the crystallization,nucleation,and growth temperatures.Nevertheless,low-molecular-weight PB-1(LMWPB-1)faces challenges because this method requires a low crystallization temperature,which is difficult to achieve during extrusion processing.In this study,we attempted to increase the phase transition rate in PB-1 by changing the annealing temperature after processing rather than the crystallization temperature in the classical scheme.The results indicated that regardless of low-or high-molecular-weight PB-1,repeated annealing between 0 and 90℃could also promote formⅡto formⅠphase transition.The initial content of formⅠincreased with the heating and cooling cycles.The half-time of the phase transition(t1/2)was also shortened after heating/cooling.After 100 heating/cooling cycles,t1/2 was reduced to one-quarter of that without annealing,which had almost the same effect as the crystallization temperature at 25℃in promoting the phase transition.This study indicates that annealing after processing is also an important factor affecting the phase transition of PB-1,and should receive sufficient attention.展开更多
Objective To evaluate the correlation between programmed death-ligand 1 (PD-L1) expression in primary lung cancer cells, tumor associated macrophages (TAM) and patients' clinicopathological characteristics. Metho...Objective To evaluate the correlation between programmed death-ligand 1 (PD-L1) expression in primary lung cancer cells, tumor associated macrophages (TAM) and patients' clinicopathological characteristics. Methods From 2008 to 2010, 208 non-small cell lung cancer patients who underwent surgery or CT-guided biopsy were recruited from Huadong Hospital, Fudan University. Immunohistochemistry staining was performed to evaluate the PD-L1 expression in both primary lung cancer cells and CD68 positive TAM.展开更多
BACKGROUND A one-stage laparoscopic operation has recently been considered a favorable option for the management of patients with Hirschsprung's disease(HD)due to its superior cosmetic results.One-stage transanal ...BACKGROUND A one-stage laparoscopic operation has recently been considered a favorable option for the management of patients with Hirschsprung's disease(HD)due to its superior cosmetic results.One-stage transanal endorectal pull-through for the treatment of rectosigmoid HD has been widely used in newborns without complications.However,enterostomy is required in some HD cases for enterocolitis and dilated colon.Our transumbilical enterostomy(TUE)and twostage laparoscopy-assisted anorectoplasty were effective and achieved a similar cosmetic effect to one-stage laparoscopy on the abdominal wall in patients with anorectal malformation,but the effect in patients with HD is unclear.AIM To evaluate the safety,efficacy and cosmetic results of TUE in two-stage laparoscopy-assisted pull-through for HD.METHODS From June 2013 to June 2018,53 patients(40 boys,13 girls;mean age at enterostomy:5.5±2.2 mo)who underwent enterostomy and two-stage laparoscopy-assisted pull-through for HD with stoma closure were reviewed at our institution.Two enterostomy approaches were used:TUE in 24 patients,and conventional abdominal enterostomy(CAE)in 29 patients.Eleven patients with rectosigmoid HD had severe preoperative enterocolitis or a dilated colon.26 patients had long-segment HD,and 16 patients had total colonic aganglionosis(TCA).The patients with left-sided HD underwent the two-stage laparoscopic Soave procedure,and the patients with right-sided HD and TCA underwent the laparoscopic Duhamel procedure.Demographics,enterostomy operative time,complications and cosmetic results were respectively evaluated.RESULTS There were no differences between the groups with respect to gender,age at enterostomy,weight and clinical type(P>0.05).No conversion to open technique was required.Two patients experienced episodes of stomal mucosal prolapse in the TUE group and 1 patient in the CAE group(8.33%vs 3.45%,P>0.05).No parastomal hernia was observed in either of the two groups.Wound infection at the stoma was seen in 1 case in the TUE group,and 2 cases in the CAE group(4.17%vs 6.90%,P>0.05).No obstruction was noted in any of the patients in the TUE group,whereas obstruction was found in 1 patient in the CAE group.Enterocolitis was observed in 3 and 5 patients in the TUE and CAE group,respectively(12.50%vs 17.24%,P>0.05).There was no significant difference between the TUE group and CAE group in terms of the incidence of soiling and constipation(P>0.05).The cosmetic result using the scar score in the TUE group was better than that in the CAE group(6.83±0.96 vs 13.32±1.57,P<0.05).CONCLUSION TUE is a safe and feasible method for the treatment of HD,and the staged enterostomy and two-stage laparoscopy-assisted pull-through achieved a similar cosmetic effect to the one-stage laparoscopic procedure.展开更多
The amplitude versus offset/angle(AVO/AVA)inversion which recovers elastic properties of subsurface media is an essential tool in oil and gas exploration.In general,the exact Zoeppritz equation has a relatively high a...The amplitude versus offset/angle(AVO/AVA)inversion which recovers elastic properties of subsurface media is an essential tool in oil and gas exploration.In general,the exact Zoeppritz equation has a relatively high accuracy in modelling the reflection coefficients.However,amplitude inversion based on it is highly nonlinear,thus,requires nonlinear inversion techniques like the genetic algorithm(GA)which has been widely applied in seismology.The quantum genetic algorithm(QGA)is a variant of the GA that enjoys the advantages of quantum computing,such as qubits and superposition of states.It,however,suffers from limitations in the areas of convergence rate and escaping local minima.To address these shortcomings,in this study,we propose a hybrid quantum genetic algorithm(HQGA)that combines a self-adaptive rotating strategy,and operations of quantum mutation and catastrophe.While the selfadaptive rotating strategy improves the flexibility and efficiency of a quantum rotating gate,the operations of quantum mutation and catastrophe enhance the local and global search abilities,respectively.Using the exact Zoeppritz equation,the HQGA was applied to both synthetic and field seismic data inversion and the results were compared to those of the GA and QGA.A number of the synthetic tests show that the HQGA requires fewer searches to converge to the global solution and the inversion results have generally higher accuracy.The application to field data reveals a good agreement between the inverted parameters and real logs.展开更多
On the basis of research method in FTIR imaging, we made a heterogeneous thin film of isotactic polypropylene (iPP) that contains a few large spherulites (-150 μm) which are surrounded by small spherulites (-15 ...On the basis of research method in FTIR imaging, we made a heterogeneous thin film of isotactic polypropylene (iPP) that contains a few large spherulites (-150 μm) which are surrounded by small spherulites (-15 μm) for tensile testing. The evolution processes of crystalline and amorphous orientations of iPP are monitored with its characteristic peaks at 998 and 973 cm^-1, respectively. By introducing the correlation images, the analysis demonstrates the relationships between the orientation evolutions of crystalline and amorphous phases in a space of 250 μm × 250 μm detecting area. During the plastic deformation, crystalline orientation is higher than amorphous orientation outside the large spherulite, while that is opposite inside the region. In addition, the evolutions of crystalline and amorphous orientations almost keep a positive correlation.展开更多
In this study, recovery processes of isotactic polypropylene (iPP) melted spherulites at 135 ℃ after melting at higher temperatures (170 ℃-176 ℃) were investigated with polarized optical microscopy and Fourier ...In this study, recovery processes of isotactic polypropylene (iPP) melted spherulites at 135 ℃ after melting at higher temperatures (170 ℃-176 ℃) were investigated with polarized optical microscopy and Fourier transform infrared spectroscopy. The recovery temperature was fixed to exclude the interference from heterogeneous nuclei. After melting at temperatures between 170 ℃ and 174 ℃, the melted spherulite could recover back to the origin spberulite at low temperatures. Interestingly, a distinct infrared spectrum from iPP melt and crystal was observed in the early stage of recovery process after melting at low temperatures, where only IR bands resulting from short helices with 12 monomers or less can be seen, which indicates that the presence of crystal residues is not the necessary condition for the polymer memory effect. Avrami analysis further indicated that crystallization mainly took place in melted lamellae. After melting at higher temperatures, melted spherulite cannot recover. Based on above findings, it is proposed that the memory effect can be mainly ascribed to melted lamellae, during which crystalline order is lost but conformational order still exists. These conformational ordered segments formed aggregates, which can play as nucleation precursors at low temperatures.展开更多
BACKGROUND Thrombocytopenia associated with acute kidney injury is a challenging disorder. Thrombotic microangiopathy (TMA) is a potentially life- or organ-threatening syndrome that can be induced by several disorders...BACKGROUND Thrombocytopenia associated with acute kidney injury is a challenging disorder. Thrombotic microangiopathy (TMA) is a potentially life- or organ-threatening syndrome that can be induced by several disorders or medical interventions. There is overlap between the clinical presentation and pathophysiology of thrombotic thrombocytopenia purpura and hemolytic uremic syndrome (HUS), and to a lesser extent, disseminated intravascular coagulation (DIC). We describe a case to illustrate the potential diagnostic difficulty, especially at initial presentation. CASE SUMMARY We reported a case of a 44-year-old woman that presented with diarrhea, thrombocytopenia, schistocytes, elevated serum lactate dehydrogenase (LDH) level and acute kidney injury. While the clinical presentation resembled that of Shiga toxin–induced HUS, the disease course was more consistent with gastrointestinal infection-related DIC. To aid in the accurate diagnosis of TMA and other associated disorders, we have undertaken a review and provided a clear interpretation of some typical biomarkers including schistocytes, LDH and platelet count, coagulation profile and more specific indexes of ADAMTS13, complement profile, and the isolation of Shiga toxin-producing Escherichia coli (commonly referred to as STEC). CONCLUSION The use and correct interpretation of classical indexes of schistocyte, LDH, and platelet count is vital in diagnosing TMA and associated disorders. Understanding the characteristics of these biomarkers in the context of thrombocytopenia purpura, HUS and DIC will facilitate the accurate diagnosis and early initiation of appropriate treatment.展开更多
In order to study influence of tongue clearance on the hydraulic performance of double support vortex pump,three dimensional flow model with symmetric variable size tongue clearance was established by changing section...In order to study influence of tongue clearance on the hydraulic performance of double support vortex pump,three dimensional flow model with symmetric variable size tongue clearance was established by changing section parameter of tongue clearance,and applied to numerically simulate the steady inner flow in a vortex pump based on fixed working conditions and impeller through ANSYS FLUENT.The numerical results show the influence of tongue channel with two sections(non-uniform and uniform sections)on flow field characteristics in vortex pump.Firstly,the variation of tongue channel section changes the vortex structure distribution in circumferential flow channel.Specifically the spiral forward vortex structure in the circumferential direction shifts to large radius side with increasing tongue width.Secondly,the circumferential velocity gradient and axial pressure gradient both diminish with the increase of the tongue section,and the inlet/outlet pressure difference and velocity distribution also reduce with increasing tongue channel section.Finally,for vortex pump with non-uniform section of tongue channel,the head diminishes and the efficiency remains constant approximately with the increase of the tongue width,while the head and the efficiency both diminish for uniform section of tongue channel.展开更多
BACKGROUND Diabetic retinopathy(DR)is a common microvascular complication of diabetes mellitus.Its blindness rate is high;therefore,finding a reasonable and safe treatment plan to prevent and control DR is crucial.Cur...BACKGROUND Diabetic retinopathy(DR)is a common microvascular complication of diabetes mellitus.Its blindness rate is high;therefore,finding a reasonable and safe treatment plan to prevent and control DR is crucial.Currently,there are abundant and diverse research results on the treatment of DR by Chinese medicine Traditional Chinese medicine compounds are potentially advantageous for DR prevention and treatment because of its safe and effective therapeutic effects.AIM To investigate the effects of Buqing granule(BQKL)on DR and its mechanism from a systemic perspective and at the molecular level by combining network pharmacology and in vivo experiments.METHODS This study collected information on the drug targets of BQKL and the therapeutic targets of DR for intersecting target gene analysis and protein-protein interactions(PPI),identified various biological pathways related to DR treatment by BQKL through Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses,and preliminarily validated the screened core targets by molecular docking.Furthermore,we constructed a diabetic rat model with a high-fat and high-sugar diet and intraperitoneal streptozotocin injection,and administered the appropriate drugs for 12 weeks after the model was successfully induced.Body mass and fasting blood glucose and lipid levels were measured,and pathological changes in retinal tissue were detected by hematoxylin and eosin staining.ELISA was used to detect the oxidative stress index expression in serum and retinal tissue,and immunohistochemistry,real-time quantitative reverse transcription PCR,and western blotting were used to verify the changes in the expression of core targets.RESULTS Six potential therapeutic targets of BQKL for DR treatment,including Caspase-3,c-Jun,TP53,AKT1,MAPK1,and MAPK3,were screened using PPI.Enrichment analysis indicated that the MAPK signaling pathway might be the core target pathway of BQKL in DR treatment.Molecular docking prediction indicated that BQKL stably bound to these core targets.In vivo experiments have shown that compared with those in the Control group,rats in the Model group had statistically significant(P<0.05)severe retinal histopathological damage;elevated blood glucose,lipid,and malondialdehyde(MDA)levels;increased Caspase-3,c-Jun,and TP53 protein expression;and reduced superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)levels,ganglion cell number,AKT1,MAPK1,and MAPK3 protein expression.Compared with the Model group,BQKL group had reduced histopathological retinal damage and the expression of blood glucose and lipids,MDA level,Caspase-3,c-Jun and TP53 proteins were reduced,while the expression of SOD,GSH-Px level,the number of ganglion cells,AKT1,MAPK1,and MAPK3 proteins were elevated.These differences were statistically significant(P<0.05).CONCLUSION BQKL can delay DR onset and progression by attenuating oxidative stress and inflammatory responses and regulating Caspase-3,c-Jun,TP53,AKT1,MAPK1,and MAPK3 proteins in the MAPK signaling pathway mediates these alterations.展开更多
Existing studies indicate that gas hydrate-bearing formations exhibit notable seismic velocity dispersion and attenuation. The Shenhu area of the South China Sea hold significant gas hydrate resource potential;however...Existing studies indicate that gas hydrate-bearing formations exhibit notable seismic velocity dispersion and attenuation. The Shenhu area of the South China Sea hold significant gas hydrate resource potential;however, the relationship between seismic velocity dispersion, attenuation properties, and gas-hydrate saturation remains insufficiently understood. Furthermore, a significant mismatch exists between the real seismic angle gather near a well and the synthetic angle gather generated using the convolution method, and this discrepancy may arise from the seismic velocity dispersion and attenuation characteristics of the gas hydrate-bearing formations. In this paper, we develop a rock physics model that integrates White's and Dvorkin's models, accounting for varied types of gas-hydrate occurrence states,specifically tailored to the gas hydrate-bearing formations in the Shenhu area. This model is calibrated with well log data and employed to investigate how gas-hydrate saturation influences seismic velocity dispersion and attenuation. Numerical analysis reveals the coexistence of two types of gas-hydrate occurrence states in the region: high gas-hydrate saturation formations are dominated by loadbearing-type gas hydrate, and formations containing both gas hydrate and free gas may exhibit either load-bearing or pore-filling types. The seismic velocity dispersion and attenuation properties vary significantly depending on the gas-hydrate occurrence state. We further apply the proposed model to generate seismic velocity and attenuation logs at various frequencies. These logs are used in seismic forward modeling employing both the convolution method and the propagator matrix method. Well tie analysis indicates that the synthetic angle gather incorporating attenuation via the propagator matrix method aligns more closely with the real seismic angle gather than the convolution method. This study provides valuable insights into frequency-dependent amplitude versus offset(AVO) analysis and the seismic interpretation of gas hydrate-bearing formations in the South China Sea.展开更多
The seismic responses of the shale properties are critical for shale gas reservoir evaluation and production.It has been widely reported that the clay minerals have substantial influences on the seismic wave anisotrop...The seismic responses of the shale properties are critical for shale gas reservoir evaluation and production.It has been widely reported that the clay minerals have substantial influences on the seismic wave anisotropy and brittleness.Hence,knowing the seismic responses of the clay-rich shales and estimation of shale elastic properties are significant for the shale gas industry.A physical model containing two groups of shale blocks as the target formations is constructed in laboratory.The group S contains six shale blocks with different clay contents,and the group N contains six shale blocks with different porosity.The acquired 2D seismic data is used to analyze the seismic responses of two corresponding seismic lines.An anisotropic three-term inversion method is applied to one of the seismic inline to estimate the elastic properties the target shale blocks.The inversed attributes can be used to reveal the effects of shale clay contents.This study shows the substantial significance of using a physical model to observe the seismic responses of shale properties.The inversion results indicate that the anisotropic three-term inversion method could provide accurate results of elastic properties as well as the P-wave anisotropy parameter for shale formations.展开更多
Kerogen content and kerogen porosity play a significant role in elastic properties of organic-rich shales. We construct a rock physics model for organic-rich shales to quantify the effect of kerogen content and keroge...Kerogen content and kerogen porosity play a significant role in elastic properties of organic-rich shales. We construct a rock physics model for organic-rich shales to quantify the effect of kerogen content and kerogen porosity using the Kuster and Toks6z theory and the selfconsistent approximation method. Rock physics modeling results show that with the increase of kerogen content and kerogen-related porosity, the velocity and density of shales decrease, and the effect of kerogen porosity becomes more obvious only for higher kerogen content. We also find that the Poisson's ratio of the shale is not sensitive to kerogen porosity for the case of gas saturation. Finally, for the seismic reflection responses of an organic-rich shale layer, forward modeling results indicate the fifth type AVO re- sponses which correspond to a negative intercept and a positive gradient. The absolute values of intercept and gradient increase with kerogen content and kerogen porosity, and present predictable variations associated with velocities and density.展开更多
A series of 1,5-diaryl-1,4-pentadien-3-one derivatives bearing an emodin group were designed and synthesized by the combination of natural products. The antiviral activities against tobacco mosaic virus(TMV) and cuc...A series of 1,5-diaryl-1,4-pentadien-3-one derivatives bearing an emodin group were designed and synthesized by the combination of natural products. The antiviral activities against tobacco mosaic virus(TMV) and cucumber mosaic virus(CMV) in vivo were evaluated. Some of the derivatives displayed promising curative effect and protective activity against TMV. Compound D5 showed appreciable curative bioactivity on TMV approximately of 50% at 306.2 mg/m L, which was superior to ningnanmycin(409.3 mg/m L).展开更多
This study aimed to compare the predictive value of six selected anthropometric indicators for benign prostatic hyperplasia(BPH).Males over 50 years of age who underwent health examinations at the Health Management Ce...This study aimed to compare the predictive value of six selected anthropometric indicators for benign prostatic hyperplasia(BPH).Males over 50 years of age who underwent health examinations at the Health Management Center of the Second Xiangya Hospital,Central South University(Changsha,China)from June to December 2020 were enrolled in this study.The characteristic data were collected,including basic anthropometric indices,lipid parameters,six anthropometric indicators,prostate-specific antigen,and total prostate volume.The odds ratios(ORs)with 95%confidence intervals(95%CIs)for all anthropometric parameters and BPH were calculated using binary logistic regression.To assess the diagnostic capability of each indicator for BPH and identify the appropriate cutoff values,receiver operating characteristic(ROC)curves and the related areas under the curves(AUCs)were utilized.All six indicators had diagnostic value for BPH(all P≤0.001).The visceral adiposity index(VAI;AUC:0.797,95%CI:0.759–0.834)had the highest AUC and therefore the highest diagnostic value.This was followed by the cardiometabolic index(CMI;AUC:0.792,95%CI:0.753–0.831),lipid accumulation product(LAP;AUC:0.766,95%CI:0.723–0.809),waist-to-hip ratio(WHR;AUC:0.660,95%CI:0.609–0.712),waist-to-height ratio(WHtR;AUC:0.639,95%CI:0.587–0.691),and body mass index(BMI;AUC:0.592,95%CI:0.540–0.643).The sensitivity of CMI was the highest(92.1%),and WHtR had the highest specificity of 94.1%.CMI consistently showed the highest OR in the binary logistic regression analysis.BMI,WHtR,WHR,VAI,CMI,and LAP all influence the occurrence of BPH in middle-aged and older men(all P≤0.001),and CMI is the best predictor of BPH.展开更多
Black phosphorus(BP)has attracted an ever-growing interest due to its unique anisotropic two-dimensional structure,impressive photoelectronic properties and attractive application potential.However,the tools for bandg...Black phosphorus(BP)has attracted an ever-growing interest due to its unique anisotropic two-dimensional structure,impressive photoelectronic properties and attractive application potential.However,the tools for bandgap engineering and passivation via covalent modification of BP nanosheets remain limited to diazonium salt and nucleophilic addition methods,so that developing new modification strategies for BP nanosheets is crucial to explore its physical and chemical properties and enrich the toolbox for functionalization.Herein,we report the covalent modification of liquid-phase exfoliated BP nanosheets based on a rational analysis of BP structure.The modification of BP is achieved via carbene,a highly reactive organic mediate.The carbene modification improves the solubility and stability of BP nanosheets.Detailed microscopic and spectroscopic characterizations including infrared spectra,Raman spectra,X-ray photoelectron spectra,SEM and TEM were conducted to provide insights for the reaction.The proof of the existence of covalent bonds between BP nanosheets and organic moieties confirms the successful modification.Moreover,theoretical calculations were conducted to unveil the reaction mechanism of the two different types of bonds and the chemical property of two-dimensional BP.展开更多
The rapid growth of the Internet of Things(IoT)demands efficient system architectures and protocols to ensure consistent performance at scale.This paper explores the scalability of IoT systems across three key layers:...The rapid growth of the Internet of Things(IoT)demands efficient system architectures and protocols to ensure consistent performance at scale.This paper explores the scalability of IoT systems across three key layers:sensing,network,and control.IoT scalability is the ability of a system to maintain consistent and reliable performance despite a continuous increase in connected devices.To evaluate scalability,we introduce the scalability indicator(SI),a metric designed to assess an IoT system’s scalability capability.Through extensive research and real-world deployments,we identify key challenges in data sensing,routing,and system control.Our study presents a model to understand these challenges and proposes strategies to optimize resource utilization,ensuring efficient data collection.The findings also emphasize the key influencing factors for the stable performance of large-scale IoT systems,providing valuable insights for how to design scalable systems that can meet the growing demand for interconnected devices.展开更多
Through the study of the corrosion behavior of Q235 steel in actual Yingtan soil and two simulated acidic soils with different water contents, the calculation of corrosion mass losses, and the analysis of the corrosio...Through the study of the corrosion behavior of Q235 steel in actual Yingtan soil and two simulated acidic soils with different water contents, the calculation of corrosion mass losses, and the analysis of the corrosion mor- phologies and products by means of scanning electron microscope (SEM) and X-ray diffraction (XRD), the results demonstrated that the diatomite soil could simulate the corrosion in actual soil veritably. In both actual soil and simu- lated soil with 16.4% water content, the corrosion rates of Q235 steel were approximately 0.1 mm/a, the corrosion morphologies were mainly extension and connection of corrosion spots on sample surface, and the corrosion products were composed of a-FeOOH, γ-FeOOH, Fe3 O4 and Fe2O3. When other media conditions remained unchanged, the corrosion area of Q235 steel was larger in simulated soil with 34.5 % water content, and the corrosion rate reached 0.48 mm/a after 360 h of corrosion, which was nearly 5 times as the value in actual soil. Compared with the corro- sion products in actual soil, the proportion of γ-FeOOH in simulated soil with 34.5 % water content was higher, and the wα-FeOOH/wγ-FeOOH ratio was 1. 4, which was only 1/3 of the value in actual soil.展开更多
To improve the corrosion resistance of steels for grounding grids, a low-carbon Cr micro-alloyed steel was developed (C 1 steel), and corrosion behavior of Q235 steel and newly developed C1 steel in simulated acidic...To improve the corrosion resistance of steels for grounding grids, a low-carbon Cr micro-alloyed steel was developed (C 1 steel), and corrosion behavior of Q235 steel and newly developed C1 steel in simulated acidic soil was investigated. The corrosion rate was evaluated with the mass loss measurements, while the corrosion morphology of surface and cross section of rust layer was observed by scanning electron microscopy. The corrosion products were analyzed by energy- dispersive X-ray spectrometry, X-ray diffraction and X-ray photoelectron spectroscopy, and the polarization curve was measured using potentiodynamic polarization method. Results indicated that C 1 steel displayed good corrosion resistance in the simulated acidic soil, of which the corrosion rate was only 30% of that of Q235 steel after corrosion for 360 h. The analysis of rust layer showed that lower carbon content in steel could reduce the tendency of micro cell corrosion and appropriate amount of chromium could improve the corrosion potential of metal matrix. Moreover, the analysis of X-ray photoelectron spectroscopy revealed that the chromium enriched in inner rust layer of C1 steel existed mainly in the form of Fe2CrO4, which facilitated the formation of Cr-goethite and improved the protection of corrosion products.展开更多
基金supported by National Natural Science Foundation of China(W2431028)the SINOPEC Fundamental Research Program(P24258)the CNPC Investigations on fundamental experiments and advanced theoretical methods in geophysical prospecting applications(2022DQ0604-02)。
摘要Shear wave splitting(SWS)analysis has been widely employed for fracture characterization in both global seismology and seismic exploration.Two key SWS attributes—fast shear wave polarization and the time delay between fast and slow shear waves—can be inverted from four-component seismic data(two horizontal sources and two horizontal receivers).These SWS attributes enable the characterization of subsurface fracture parameters,such as fracture strike and density.In this study,a nine-component vertical seismic profile(VSP)survey was acquired in the Sanhu Depression of the eastern Qaidam Basin,northwestern China.Preliminary analysis of the shear-wave source VSP data reveals two distinct SWS signatures at different depths,corresponding to two separate fractured layers.However,characterizing multiple fractured layers presents significant challenges,as the SWS attributes of deeper fractured layers are strongly influenced by those of overlying fractured formations.Existing approaches for predicting multi-layer fracture parameters are predominantly data-driven and are largely limited to qualitative analysis.To address these challenges,we propose a robust,rock-physics-model-guided method that enables the quantitative estimation of both the fracture strike and fracture density in multiple fractured laye rs.First,the parameters of the shallow fractu red layer are directly estimated from the SWS attributes.Then,synthetic VSP records of the deeper fractured layer are modeled by incorporating Hudson's theory and the reflectivity method.The fracture parameters of the deep fractured layer are inverted by minimizing the difference between the SWS attributes of synthetic records and those of the actual seismic data.A hierarchical search strategy(coarse-scale+refined-scale)is employed to accelerate convergence toward the optimal solution.This investigation provides a practical tool for quantitative characterization of subsurface formations with multiple fractured layers.
基金supported by the research project of the China National Petroleum Corporation under grant numbers 2021ZG02 and 2023ZZ05。
摘要In the fields of reservoir fracture prediction and fracturing monitoring,shear-wave splitting analysis has exhibited notable technical advantages.Compared with compressional waves,it offers a more robust capability for predicting the orientation and extent of fracture development systems or formation heterogeneity.In regions characterized by vertically or unidirectionally fractured thin interbedded formations,conventional shear-wave splitting analysis and correction methods based on the HTI(Horizontal Transverse Isotropy)medium model are inadequate.These methods fail to account for the increased propagation time difference between fast and slow shear-waves as they accumulate through layered media.This limitation arises because the subsurface medium in such scenarios is more accurately approximated by an orthotropic medium model.To address this challenge,shear-wave splitting analysis and correction methods based on orthotropic media have been developed and implemented.The method first determines the fracture orientation using established techniques,then separates the fast and slow shear-waves through wavefield rotation,and finally employs a matching algorithm to compute the instantaneous time difference between the fast and slow shear-waves.By introducing time-varying delay correction,this approach enables the accurate estimation of delay values that better reflect the actual properties of the subsurface medium.As a result,it enhances the precision of fracture detection in targeted formation intervals.The method has demonstrated excellent performance in both synthetic model and real-data applications.
基金financially supported by the National Natural Science Foundation of China(No.22175183)。
摘要The slow phase transition from formⅡto formⅠhas always been an important factor that restricts the processing and application of polybutene-1(PB-1).After extensive efforts,a set of effective methods for promoting the phase transition rate in PB-1 was established by adjusting the crystallization,nucleation,and growth temperatures.Nevertheless,low-molecular-weight PB-1(LMWPB-1)faces challenges because this method requires a low crystallization temperature,which is difficult to achieve during extrusion processing.In this study,we attempted to increase the phase transition rate in PB-1 by changing the annealing temperature after processing rather than the crystallization temperature in the classical scheme.The results indicated that regardless of low-or high-molecular-weight PB-1,repeated annealing between 0 and 90℃could also promote formⅡto formⅠphase transition.The initial content of formⅠincreased with the heating and cooling cycles.The half-time of the phase transition(t1/2)was also shortened after heating/cooling.After 100 heating/cooling cycles,t1/2 was reduced to one-quarter of that without annealing,which had almost the same effect as the crystallization temperature at 25℃in promoting the phase transition.This study indicates that annealing after processing is also an important factor affecting the phase transition of PB-1,and should receive sufficient attention.
摘要Objective To evaluate the correlation between programmed death-ligand 1 (PD-L1) expression in primary lung cancer cells, tumor associated macrophages (TAM) and patients' clinicopathological characteristics. Methods From 2008 to 2010, 208 non-small cell lung cancer patients who underwent surgery or CT-guided biopsy were recruited from Huadong Hospital, Fudan University. Immunohistochemistry staining was performed to evaluate the PD-L1 expression in both primary lung cancer cells and CD68 positive TAM.
基金Supported by the Public Welfare Research and Special Fund of the National Health and Family Planning of China,No.201402007
摘要BACKGROUND A one-stage laparoscopic operation has recently been considered a favorable option for the management of patients with Hirschsprung's disease(HD)due to its superior cosmetic results.One-stage transanal endorectal pull-through for the treatment of rectosigmoid HD has been widely used in newborns without complications.However,enterostomy is required in some HD cases for enterocolitis and dilated colon.Our transumbilical enterostomy(TUE)and twostage laparoscopy-assisted anorectoplasty were effective and achieved a similar cosmetic effect to one-stage laparoscopy on the abdominal wall in patients with anorectal malformation,but the effect in patients with HD is unclear.AIM To evaluate the safety,efficacy and cosmetic results of TUE in two-stage laparoscopy-assisted pull-through for HD.METHODS From June 2013 to June 2018,53 patients(40 boys,13 girls;mean age at enterostomy:5.5±2.2 mo)who underwent enterostomy and two-stage laparoscopy-assisted pull-through for HD with stoma closure were reviewed at our institution.Two enterostomy approaches were used:TUE in 24 patients,and conventional abdominal enterostomy(CAE)in 29 patients.Eleven patients with rectosigmoid HD had severe preoperative enterocolitis or a dilated colon.26 patients had long-segment HD,and 16 patients had total colonic aganglionosis(TCA).The patients with left-sided HD underwent the two-stage laparoscopic Soave procedure,and the patients with right-sided HD and TCA underwent the laparoscopic Duhamel procedure.Demographics,enterostomy operative time,complications and cosmetic results were respectively evaluated.RESULTS There were no differences between the groups with respect to gender,age at enterostomy,weight and clinical type(P>0.05).No conversion to open technique was required.Two patients experienced episodes of stomal mucosal prolapse in the TUE group and 1 patient in the CAE group(8.33%vs 3.45%,P>0.05).No parastomal hernia was observed in either of the two groups.Wound infection at the stoma was seen in 1 case in the TUE group,and 2 cases in the CAE group(4.17%vs 6.90%,P>0.05).No obstruction was noted in any of the patients in the TUE group,whereas obstruction was found in 1 patient in the CAE group.Enterocolitis was observed in 3 and 5 patients in the TUE and CAE group,respectively(12.50%vs 17.24%,P>0.05).There was no significant difference between the TUE group and CAE group in terms of the incidence of soiling and constipation(P>0.05).The cosmetic result using the scar score in the TUE group was better than that in the CAE group(6.83±0.96 vs 13.32±1.57,P<0.05).CONCLUSION TUE is a safe and feasible method for the treatment of HD,and the staged enterostomy and two-stage laparoscopy-assisted pull-through achieved a similar cosmetic effect to the one-stage laparoscopic procedure.
基金supported by the National Natural Science Foundation of China(U19B6003,42122029)the Strategic Cooperation Technology Projects of CNPC and CUPB(ZLZX 202003)partially supported by SEG/WesternGeco Scholarship,SEG Foundation/Chevron Scholarship,and SEG/Norman and Shirley Domenico Scholarship
摘要The amplitude versus offset/angle(AVO/AVA)inversion which recovers elastic properties of subsurface media is an essential tool in oil and gas exploration.In general,the exact Zoeppritz equation has a relatively high accuracy in modelling the reflection coefficients.However,amplitude inversion based on it is highly nonlinear,thus,requires nonlinear inversion techniques like the genetic algorithm(GA)which has been widely applied in seismology.The quantum genetic algorithm(QGA)is a variant of the GA that enjoys the advantages of quantum computing,such as qubits and superposition of states.It,however,suffers from limitations in the areas of convergence rate and escaping local minima.To address these shortcomings,in this study,we propose a hybrid quantum genetic algorithm(HQGA)that combines a self-adaptive rotating strategy,and operations of quantum mutation and catastrophe.While the selfadaptive rotating strategy improves the flexibility and efficiency of a quantum rotating gate,the operations of quantum mutation and catastrophe enhance the local and global search abilities,respectively.Using the exact Zoeppritz equation,the HQGA was applied to both synthetic and field seismic data inversion and the results were compared to those of the GA and QGA.A number of the synthetic tests show that the HQGA requires fewer searches to converge to the global solution and the inversion results have generally higher accuracy.The application to field data reveals a good agreement between the inverted parameters and real logs.
基金financially supported by the China Postdoctoral Science Foundation(No.2012M521233)the Fundamental Research Funds for the Central Universities(No.WK2310000031)+1 种基金the National Natural Science Funds for Distinguished Young Scholar(No.51325301)973 program of MOST(No.2010CB934504)
摘要On the basis of research method in FTIR imaging, we made a heterogeneous thin film of isotactic polypropylene (iPP) that contains a few large spherulites (-150 μm) which are surrounded by small spherulites (-15 μm) for tensile testing. The evolution processes of crystalline and amorphous orientations of iPP are monitored with its characteristic peaks at 998 and 973 cm^-1, respectively. By introducing the correlation images, the analysis demonstrates the relationships between the orientation evolutions of crystalline and amorphous phases in a space of 250 μm × 250 μm detecting area. During the plastic deformation, crystalline orientation is higher than amorphous orientation outside the large spherulite, while that is opposite inside the region. In addition, the evolutions of crystalline and amorphous orientations almost keep a positive correlation.
基金financially supported by the China Postdoctoral Science Foundation(No.2012M521233)the Fundamental Research Funds for the Central Universities(WK2310000031)+3 种基金the National Natural Science Foundation of China(Nos.51033004,51227801,51303166)National Natural Science Funds for Distinguished Young Scholars(No.51325301)the 973 program of MOST(2010CB934504)supported by the Opening Project of Soochow University Biomedical Polymers Laboratory and the Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application(Soochow University)
摘要In this study, recovery processes of isotactic polypropylene (iPP) melted spherulites at 135 ℃ after melting at higher temperatures (170 ℃-176 ℃) were investigated with polarized optical microscopy and Fourier transform infrared spectroscopy. The recovery temperature was fixed to exclude the interference from heterogeneous nuclei. After melting at temperatures between 170 ℃ and 174 ℃, the melted spherulite could recover back to the origin spberulite at low temperatures. Interestingly, a distinct infrared spectrum from iPP melt and crystal was observed in the early stage of recovery process after melting at low temperatures, where only IR bands resulting from short helices with 12 monomers or less can be seen, which indicates that the presence of crystal residues is not the necessary condition for the polymer memory effect. Avrami analysis further indicated that crystallization mainly took place in melted lamellae. After melting at higher temperatures, melted spherulite cannot recover. Based on above findings, it is proposed that the memory effect can be mainly ascribed to melted lamellae, during which crystalline order is lost but conformational order still exists. These conformational ordered segments formed aggregates, which can play as nucleation precursors at low temperatures.
摘要BACKGROUND Thrombocytopenia associated with acute kidney injury is a challenging disorder. Thrombotic microangiopathy (TMA) is a potentially life- or organ-threatening syndrome that can be induced by several disorders or medical interventions. There is overlap between the clinical presentation and pathophysiology of thrombotic thrombocytopenia purpura and hemolytic uremic syndrome (HUS), and to a lesser extent, disseminated intravascular coagulation (DIC). We describe a case to illustrate the potential diagnostic difficulty, especially at initial presentation. CASE SUMMARY We reported a case of a 44-year-old woman that presented with diarrhea, thrombocytopenia, schistocytes, elevated serum lactate dehydrogenase (LDH) level and acute kidney injury. While the clinical presentation resembled that of Shiga toxin–induced HUS, the disease course was more consistent with gastrointestinal infection-related DIC. To aid in the accurate diagnosis of TMA and other associated disorders, we have undertaken a review and provided a clear interpretation of some typical biomarkers including schistocytes, LDH and platelet count, coagulation profile and more specific indexes of ADAMTS13, complement profile, and the isolation of Shiga toxin-producing Escherichia coli (commonly referred to as STEC). CONCLUSION The use and correct interpretation of classical indexes of schistocyte, LDH, and platelet count is vital in diagnosing TMA and associated disorders. Understanding the characteristics of these biomarkers in the context of thrombocytopenia purpura, HUS and DIC will facilitate the accurate diagnosis and early initiation of appropriate treatment.
基金the National Natural Science Foundation of China(No. 51575420)the Local Service Special Project of the Education Department of Shaanxi Province, China (No. 14 JF011)+1 种基金the Special Fund Project of Major Science and Technology Innovation of Shaanxi Province, China (No. 2017ZKC0124, No. 2018TP-17)Xi’an Science and Technology project, China (No. 201805032YD10CG16(5)) for the support
摘要In order to study influence of tongue clearance on the hydraulic performance of double support vortex pump,three dimensional flow model with symmetric variable size tongue clearance was established by changing section parameter of tongue clearance,and applied to numerically simulate the steady inner flow in a vortex pump based on fixed working conditions and impeller through ANSYS FLUENT.The numerical results show the influence of tongue channel with two sections(non-uniform and uniform sections)on flow field characteristics in vortex pump.Firstly,the variation of tongue channel section changes the vortex structure distribution in circumferential flow channel.Specifically the spiral forward vortex structure in the circumferential direction shifts to large radius side with increasing tongue width.Secondly,the circumferential velocity gradient and axial pressure gradient both diminish with the increase of the tongue section,and the inlet/outlet pressure difference and velocity distribution also reduce with increasing tongue channel section.Finally,for vortex pump with non-uniform section of tongue channel,the head diminishes and the efficiency remains constant approximately with the increase of the tongue width,while the head and the efficiency both diminish for uniform section of tongue channel.
基金Supported by National Natural Science Foundation of China,No.81960836Ningxia Natural Science Foundation,No.2020AAC03126Ningxia Higher Education Scientific Research Project,No.NGY2020045。
摘要BACKGROUND Diabetic retinopathy(DR)is a common microvascular complication of diabetes mellitus.Its blindness rate is high;therefore,finding a reasonable and safe treatment plan to prevent and control DR is crucial.Currently,there are abundant and diverse research results on the treatment of DR by Chinese medicine Traditional Chinese medicine compounds are potentially advantageous for DR prevention and treatment because of its safe and effective therapeutic effects.AIM To investigate the effects of Buqing granule(BQKL)on DR and its mechanism from a systemic perspective and at the molecular level by combining network pharmacology and in vivo experiments.METHODS This study collected information on the drug targets of BQKL and the therapeutic targets of DR for intersecting target gene analysis and protein-protein interactions(PPI),identified various biological pathways related to DR treatment by BQKL through Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses,and preliminarily validated the screened core targets by molecular docking.Furthermore,we constructed a diabetic rat model with a high-fat and high-sugar diet and intraperitoneal streptozotocin injection,and administered the appropriate drugs for 12 weeks after the model was successfully induced.Body mass and fasting blood glucose and lipid levels were measured,and pathological changes in retinal tissue were detected by hematoxylin and eosin staining.ELISA was used to detect the oxidative stress index expression in serum and retinal tissue,and immunohistochemistry,real-time quantitative reverse transcription PCR,and western blotting were used to verify the changes in the expression of core targets.RESULTS Six potential therapeutic targets of BQKL for DR treatment,including Caspase-3,c-Jun,TP53,AKT1,MAPK1,and MAPK3,were screened using PPI.Enrichment analysis indicated that the MAPK signaling pathway might be the core target pathway of BQKL in DR treatment.Molecular docking prediction indicated that BQKL stably bound to these core targets.In vivo experiments have shown that compared with those in the Control group,rats in the Model group had statistically significant(P<0.05)severe retinal histopathological damage;elevated blood glucose,lipid,and malondialdehyde(MDA)levels;increased Caspase-3,c-Jun,and TP53 protein expression;and reduced superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)levels,ganglion cell number,AKT1,MAPK1,and MAPK3 protein expression.Compared with the Model group,BQKL group had reduced histopathological retinal damage and the expression of blood glucose and lipids,MDA level,Caspase-3,c-Jun and TP53 proteins were reduced,while the expression of SOD,GSH-Px level,the number of ganglion cells,AKT1,MAPK1,and MAPK3 proteins were elevated.These differences were statistically significant(P<0.05).CONCLUSION BQKL can delay DR onset and progression by attenuating oxidative stress and inflammatory responses and regulating Caspase-3,c-Jun,TP53,AKT1,MAPK1,and MAPK3 proteins in the MAPK signaling pathway mediates these alterations.
基金supported by National Natural Science Foundation of China(W2431028,42122029)SINOPEC Fundamental Research Program(P24258)CNPC Investigations on fundamental experiments and advanced theoretical methods in geophysical prospecting applications(2022DQ0604-02).
摘要Existing studies indicate that gas hydrate-bearing formations exhibit notable seismic velocity dispersion and attenuation. The Shenhu area of the South China Sea hold significant gas hydrate resource potential;however, the relationship between seismic velocity dispersion, attenuation properties, and gas-hydrate saturation remains insufficiently understood. Furthermore, a significant mismatch exists between the real seismic angle gather near a well and the synthetic angle gather generated using the convolution method, and this discrepancy may arise from the seismic velocity dispersion and attenuation characteristics of the gas hydrate-bearing formations. In this paper, we develop a rock physics model that integrates White's and Dvorkin's models, accounting for varied types of gas-hydrate occurrence states,specifically tailored to the gas hydrate-bearing formations in the Shenhu area. This model is calibrated with well log data and employed to investigate how gas-hydrate saturation influences seismic velocity dispersion and attenuation. Numerical analysis reveals the coexistence of two types of gas-hydrate occurrence states in the region: high gas-hydrate saturation formations are dominated by loadbearing-type gas hydrate, and formations containing both gas hydrate and free gas may exhibit either load-bearing or pore-filling types. The seismic velocity dispersion and attenuation properties vary significantly depending on the gas-hydrate occurrence state. We further apply the proposed model to generate seismic velocity and attenuation logs at various frequencies. These logs are used in seismic forward modeling employing both the convolution method and the propagator matrix method. Well tie analysis indicates that the synthetic angle gather incorporating attenuation via the propagator matrix method aligns more closely with the real seismic angle gather than the convolution method. This study provides valuable insights into frequency-dependent amplitude versus offset(AVO) analysis and the seismic interpretation of gas hydrate-bearing formations in the South China Sea.
基金supported by the National Natural Science Fund Projects(U19B6003)Strategic Cooperation Technology Projects of CNPC and CUPB(ZLZX2020-03)the Science Foundation of China University of Petroleum(Beijing)(2462020YXZZ008)。
摘要The seismic responses of the shale properties are critical for shale gas reservoir evaluation and production.It has been widely reported that the clay minerals have substantial influences on the seismic wave anisotropy and brittleness.Hence,knowing the seismic responses of the clay-rich shales and estimation of shale elastic properties are significant for the shale gas industry.A physical model containing two groups of shale blocks as the target formations is constructed in laboratory.The group S contains six shale blocks with different clay contents,and the group N contains six shale blocks with different porosity.The acquired 2D seismic data is used to analyze the seismic responses of two corresponding seismic lines.An anisotropic three-term inversion method is applied to one of the seismic inline to estimate the elastic properties the target shale blocks.The inversed attributes can be used to reveal the effects of shale clay contents.This study shows the substantial significance of using a physical model to observe the seismic responses of shale properties.The inversion results indicate that the anisotropic three-term inversion method could provide accurate results of elastic properties as well as the P-wave anisotropy parameter for shale formations.
基金supported by the National Natural Science Foundation of China under Grants U1262208the National Natural Science Foundation of China under Grants 41404090
摘要Kerogen content and kerogen porosity play a significant role in elastic properties of organic-rich shales. We construct a rock physics model for organic-rich shales to quantify the effect of kerogen content and kerogen porosity using the Kuster and Toks6z theory and the selfconsistent approximation method. Rock physics modeling results show that with the increase of kerogen content and kerogen-related porosity, the velocity and density of shales decrease, and the effect of kerogen porosity becomes more obvious only for higher kerogen content. We also find that the Poisson's ratio of the shale is not sensitive to kerogen porosity for the case of gas saturation. Finally, for the seismic reflection responses of an organic-rich shale layer, forward modeling results indicate the fifth type AVO re- sponses which correspond to a negative intercept and a positive gradient. The absolute values of intercept and gradient increase with kerogen content and kerogen porosity, and present predictable variations associated with velocities and density.
基金assistance from the National Natural Science Foundation of China (No. 21302025)the Special Funds for Training object of Outstanding Young Scientific & Technological Talents in Guizhou Province (No. 2015-15#)the Science & Technology Foundation of Guizhou Province (No. J[2014]2056#)
摘要A series of 1,5-diaryl-1,4-pentadien-3-one derivatives bearing an emodin group were designed and synthesized by the combination of natural products. The antiviral activities against tobacco mosaic virus(TMV) and cucumber mosaic virus(CMV) in vivo were evaluated. Some of the derivatives displayed promising curative effect and protective activity against TMV. Compound D5 showed appreciable curative bioactivity on TMV approximately of 50% at 306.2 mg/m L, which was superior to ningnanmycin(409.3 mg/m L).
摘要This study aimed to compare the predictive value of six selected anthropometric indicators for benign prostatic hyperplasia(BPH).Males over 50 years of age who underwent health examinations at the Health Management Center of the Second Xiangya Hospital,Central South University(Changsha,China)from June to December 2020 were enrolled in this study.The characteristic data were collected,including basic anthropometric indices,lipid parameters,six anthropometric indicators,prostate-specific antigen,and total prostate volume.The odds ratios(ORs)with 95%confidence intervals(95%CIs)for all anthropometric parameters and BPH were calculated using binary logistic regression.To assess the diagnostic capability of each indicator for BPH and identify the appropriate cutoff values,receiver operating characteristic(ROC)curves and the related areas under the curves(AUCs)were utilized.All six indicators had diagnostic value for BPH(all P≤0.001).The visceral adiposity index(VAI;AUC:0.797,95%CI:0.759–0.834)had the highest AUC and therefore the highest diagnostic value.This was followed by the cardiometabolic index(CMI;AUC:0.792,95%CI:0.753–0.831),lipid accumulation product(LAP;AUC:0.766,95%CI:0.723–0.809),waist-to-hip ratio(WHR;AUC:0.660,95%CI:0.609–0.712),waist-to-height ratio(WHtR;AUC:0.639,95%CI:0.587–0.691),and body mass index(BMI;AUC:0.592,95%CI:0.540–0.643).The sensitivity of CMI was the highest(92.1%),and WHtR had the highest specificity of 94.1%.CMI consistently showed the highest OR in the binary logistic regression analysis.BMI,WHtR,WHR,VAI,CMI,and LAP all influence the occurrence of BPH in middle-aged and older men(all P≤0.001),and CMI is the best predictor of BPH.
基金supported by the Ministry of Science and Technology of China(No.2017YFA0204903)National Natural Science Foundation of China(NSFC.Nos.51733004,51525303,22073038,21702085)111 Project.
摘要Black phosphorus(BP)has attracted an ever-growing interest due to its unique anisotropic two-dimensional structure,impressive photoelectronic properties and attractive application potential.However,the tools for bandgap engineering and passivation via covalent modification of BP nanosheets remain limited to diazonium salt and nucleophilic addition methods,so that developing new modification strategies for BP nanosheets is crucial to explore its physical and chemical properties and enrich the toolbox for functionalization.Herein,we report the covalent modification of liquid-phase exfoliated BP nanosheets based on a rational analysis of BP structure.The modification of BP is achieved via carbene,a highly reactive organic mediate.The carbene modification improves the solubility and stability of BP nanosheets.Detailed microscopic and spectroscopic characterizations including infrared spectra,Raman spectra,X-ray photoelectron spectra,SEM and TEM were conducted to provide insights for the reaction.The proof of the existence of covalent bonds between BP nanosheets and organic moieties confirms the successful modification.Moreover,theoretical calculations were conducted to unveil the reaction mechanism of the two different types of bonds and the chemical property of two-dimensional BP.
基金supported by the National Key Research and Development Program of China under Grant No.2022YFC3801300the National Natural Science Foundation of China under Grant Nos.U22A2031 and 62172250supported by the Tsinghua University-Fuzhou Joint Institute for Data Technology and the Postdoctoral Science Foundation of China under Grant No.BX20240193.
摘要The rapid growth of the Internet of Things(IoT)demands efficient system architectures and protocols to ensure consistent performance at scale.This paper explores the scalability of IoT systems across three key layers:sensing,network,and control.IoT scalability is the ability of a system to maintain consistent and reliable performance despite a continuous increase in connected devices.To evaluate scalability,we introduce the scalability indicator(SI),a metric designed to assess an IoT system’s scalability capability.Through extensive research and real-world deployments,we identify key challenges in data sensing,routing,and system control.Our study presents a model to understand these challenges and proposes strategies to optimize resource utilization,ensuring efficient data collection.The findings also emphasize the key influencing factors for the stable performance of large-scale IoT systems,providing valuable insights for how to design scalable systems that can meet the growing demand for interconnected devices.
摘要Through the study of the corrosion behavior of Q235 steel in actual Yingtan soil and two simulated acidic soils with different water contents, the calculation of corrosion mass losses, and the analysis of the corrosion mor- phologies and products by means of scanning electron microscope (SEM) and X-ray diffraction (XRD), the results demonstrated that the diatomite soil could simulate the corrosion in actual soil veritably. In both actual soil and simu- lated soil with 16.4% water content, the corrosion rates of Q235 steel were approximately 0.1 mm/a, the corrosion morphologies were mainly extension and connection of corrosion spots on sample surface, and the corrosion products were composed of a-FeOOH, γ-FeOOH, Fe3 O4 and Fe2O3. When other media conditions remained unchanged, the corrosion area of Q235 steel was larger in simulated soil with 34.5 % water content, and the corrosion rate reached 0.48 mm/a after 360 h of corrosion, which was nearly 5 times as the value in actual soil. Compared with the corro- sion products in actual soil, the proportion of γ-FeOOH in simulated soil with 34.5 % water content was higher, and the wα-FeOOH/wγ-FeOOH ratio was 1. 4, which was only 1/3 of the value in actual soil.
摘要To improve the corrosion resistance of steels for grounding grids, a low-carbon Cr micro-alloyed steel was developed (C 1 steel), and corrosion behavior of Q235 steel and newly developed C1 steel in simulated acidic soil was investigated. The corrosion rate was evaluated with the mass loss measurements, while the corrosion morphology of surface and cross section of rust layer was observed by scanning electron microscopy. The corrosion products were analyzed by energy- dispersive X-ray spectrometry, X-ray diffraction and X-ray photoelectron spectroscopy, and the polarization curve was measured using potentiodynamic polarization method. Results indicated that C 1 steel displayed good corrosion resistance in the simulated acidic soil, of which the corrosion rate was only 30% of that of Q235 steel after corrosion for 360 h. The analysis of rust layer showed that lower carbon content in steel could reduce the tendency of micro cell corrosion and appropriate amount of chromium could improve the corrosion potential of metal matrix. Moreover, the analysis of X-ray photoelectron spectroscopy revealed that the chromium enriched in inner rust layer of C1 steel existed mainly in the form of Fe2CrO4, which facilitated the formation of Cr-goethite and improved the protection of corrosion products.