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Structural and antioxidative properties of royal jelly protein by partial enzymatic hydrolysis 认领 引用 被引量：9
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作者 Shanshan Li Lingchen Tao +3 位作者 Shiqin Peng Xinyu Yu Xiaobin Ma Fuliang Hu 《Food Science and Human Wellness》 SCIE CAS CSCD 2023年第5期1820-1827,共8页
The objective of this study was to investigate the structural and antioxidative properties of royal jelly protein(RJP)at different degrees of hydrolysis(DH)by partial enzymatic hydrolysis. RJP was hydrolyzed by alcala... The objective of this study was to investigate the structural and antioxidative properties of royal jelly protein(RJP)at different degrees of hydrolysis(DH)by partial enzymatic hydrolysis. RJP was hydrolyzed by alcalase for 0 min, 15 min, 1 h, 5 h and 8 h to obtain hydrolysates at DH of 5.34%, 11.65%, 15.19%, 21.38% and 23.91%, respectively. With the increased DH, the RJP hydrolysates showed elevated antioxidative activities. The molecular weight of RJP hydrolysates was significantly decreased but their primary backbone kept unchanged. Analysis of circular dichroism spectra revealed that the enzymolysis reduced the content of α-helix but increased the contents of β-sheet, β-turn and random coil. Meanwhile, the surface hydrophobicity and fluorescence intensity of RJP hydrolysates were decreased and a red shift occurred. As the enzymolysis continued, the surface morphology of RJP was gradually changed from a sheet-like structure into microparticles. Changes in antioxidative activities and structures generally followed a DH-dependent manner, however these changes became insignificant for samples at DH beyond 20%. Taking into consideration of both effectiveness and productivity, the optimum enzymatic duration was determined at 5 h. 展开更多
关键词 Royal jelly protein Acalase Enzymatic hydrolysis Antioxidative activity Structure
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High power focused-beam microwave hyperthermia combined with intrapleural injection of Shapeilin in the treatment of patients with malignant hydrothorax 认领 引用 被引量：2
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作者 Lingqin Song Jianjun He +5 位作者 Xijing Wang Hongbing Ma Shuqun Zhang Zhijun Dai Baofeng Wang Xiaobin Ma 《The Chinese-German Journal of Clinical Oncology》 2011年第2期77-80,共4页
Objective:The aim of the study was to evaluate the efficacy and toxicity of high power focused-beam microwave hyperthermia with intrapleural injection of Shapeilin for patients with malignant hydrothorax.Methods:Fifty... Objective:The aim of the study was to evaluate the efficacy and toxicity of high power focused-beam microwave hyperthermia with intrapleural injection of Shapeilin for patients with malignant hydrothorax.Methods:Fifty-eight patients with malignant hydrothorax were divided into group A and group B randomly.All patients underwent indwelling pleural catheter and were treated by intrapleural injection of Shapeilin once three days.Treatment was composed of 3 times injection.Patients of group B received high power focused-beam microwave hyperthermia after injection of Shapeilin.Results:The response rate of group B(79.3%) was higher than that of group A(48.3%)(P 0.05).Patients of group B didn't encounter severe toxicities of microwave hyperthermia.Conclusion:High power focused-beam microwave hyperthermia combined with intrapleural injection of Shapeilin is effective and tolerable for patients with malignant hydrothorax. 展开更多
关键词 hydrothorax hyperthermia picibanil
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The accuracy of magnetic resonance imaging and ultrasound in evaluating the size of early-stage breast neoplasms 认领 引用
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作者 Zheng Wang Hongzhi Chen +3 位作者 Xiaobin Ma Zhijun Dai Shuai Lin Huafeng Kang 《Oncology and Translational Medicine》 CAS 2016年第4期169-173,共5页
Objective Breast cancer is the most frequently diagnosed cancer in women. Accurate evaluation of the size and extent of the tumor is crucial in selecting a suitable surgical method for patients with breast cancer. Bot... Objective Breast cancer is the most frequently diagnosed cancer in women. Accurate evaluation of the size and extent of the tumor is crucial in selecting a suitable surgical method for patients with breast cancer. Both overestimation and underestimation have important adverse effects on patient care. This study aimed to evaluate the accuracy of breast magnetic resonance imaging(MRI) and ultrasound(US) examination for measuring the size and extent of early-stage breast neoplasms.Methods The longest diameter of breast tumors in patients with T1–2N0–1M_0 invasive breast cancer preparing for breast-conserving surgery(BCS) was measured preoperatively by using both MRI and US and their accuracy was compared with that of postoperative pathologic examination. If the diameter difference was within 2 mm, it was considered to be consistent with pathologic examination.Results A total of 36 patients were imaged using both MRI and US. The mean longest diameter of the tumors on MRI, US, and postoperative pathologic examination was 20.86 mm ± 4.09 mm(range: 11–27 mm), 16.14 mm ± 4.91 mm(range: 6–26 mm), and 18.36 mm ± 3.88 mm(range: 9–24 mm). US examination underestimated the size of the tumor compared to that determined using pathologic examination(t = 3.49, P 0.05).Conclusion MRI and US are both effective methods to assess the size of breast tumors, and they maintain good consistency with pathologic examination. MRI has a better correlation with pathology. However, we should be careful about the risk of inaccurate size estimation. 展开更多
关键词 breast neoplasm magnetic resonance imaging（MRI） ultrasound pathology
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Different response to neoadjuvant chemotherapy for different molecular subtypes in patients with locally advanced breast cancer 认领 引用 被引量：2
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作者 Huafeng Kang Zhijun Dai +5 位作者 Xiaobin Ma Xing Bao Shuai Lin Hongbing Ma Xiaoxu Liu Xijing Wang 《The Chinese-German Journal of Clinical Oncology》 2013年第4期163-166,共4页
Objective： The aim of this study was to evaluate the impact of different molecular subtypes defined by immunohistochemistry （IHC） staining on the response rate for patients with locally advanced breast cancer recei... Objective： The aim of this study was to evaluate the impact of different molecular subtypes defined by immunohistochemistry （IHC） staining on the response rate for patients with locally advanced breast cancer received neoadjuvant chemotherapy. Methods： One hundred and seven breast cancer patients admitted from 2007 to 2011 who received 4 cycles of docetaxel/epirubicin-combined （TE） neoadjuvant chemotherapy were retrospectively reviewed, the patients were classified into 4 subtypes： luminal A, luminal B, HER-2 and triple negative breast cancer （TNBC） according to different combination patterns of estrogen receptor （ER）, progesterone receptor （PR） and human epidermal growth factor-2 （HER-2） expression defined by IHC method. The correlation between response rate and the molecular subtypes were analyzed. Results： The pathological complete response （PCR）, clinical complete response （CCR）, clinical partial response （CPR）, and clinical stable disease （CSD） rate of whole group was 15.89% （17/107）, 22.43% （24/107）, 63.55% （68/107）, 14.02% （15/107）, respectively, and the overall response rate （ORR） was 85.98% （92/107）. The PCR rate and ORR of luminal A, luminal B, HER-2 and TNBC subtypes was 4.76% and 73.81%; 16.67% and 83.33%;17.65% and 100.00%; 30.00% and 96.67%, respectively. The PCR and ORR rate of HER-2/TNBC subtypes was higher than that of luminal A/B subtypes （P = 0.019, P = 0.002, respectively）. Conclusion： Different molecular subtypes display different response rate for patients with locally advanced breast cancer received neoadjuvant TE chemotherapy, HER-2JTNBC subtypes have a higher PCR and ORR rate than that of luminal NB subtypes. 展开更多
关键词 breast cancer molecular subtype neoadjuvant chemotherapy response rate
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Concentration control of volatile organic compounds by ionic liquid absorption and desorption 认领 引用 被引量：5
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作者 Xiaobin Ma MinyanWu +5 位作者 Shuo Liu Jinxing Huang Bin Sun Ying Zhou Qiulian Zhu Hanfeng Lu 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2019年第10期2383-2389,共7页
Volatile organic compounds(VOCs)are difficult to be eliminated safely and effectively because of their large concentration fluctuations.Thus,maintaining a stable concentration of VOCs is a significant study.In this re... Volatile organic compounds(VOCs)are difficult to be eliminated safely and effectively because of their large concentration fluctuations.Thus,maintaining a stable concentration of VOCs is a significant study.In this research,H2O,Tween-80,[Emim]BF4,[Emim]PF6,and[Hnmp]HSO4 were applied to absorb and desorb simulated VOCs.The ionic liquid[Emim]BF4 demonstrated the best performance and was thus selected for further experiments.As the ionic liquid acted as a buffer,the toluene concentration with a fluctuation of 2000–20000 mg·m-3 was stabilized at 6000–12000 mg·m-3.Heating distillation(90°C)was highly efficient to recover[Emim]BF4 from toluene.The regenerated[Emim]BF4 could retain its initial absorption capacity even after multiple cycles.Moreover,[Emim]BF4 had the same buffer function on various aromatic hydrocarbons. 展开更多
关键词 Volatile organic compounds Concentration fluctuation Absorb and desorb Ionic liquid Buffer
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