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Predictive value of triglyceride-glucose index and sex hormone-binding globulin in diabetic retinopathy 认领 引用
1
作者 Min Zhang Xin-Rui Zhou +3 位作者 Wei-Guo Ma Xiao-Hong Yin Ya Li Rong Li 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2026年第5期921-926,共6页
AIM:To investigate the levels of the triglyceride-glucose(TyG)index and sex hormone-binding globulin(SHBG)in patients with type 2 diabetes mellitus(T2DM)with diabetic retinopathy(DR),and to explore their correlations ... AIM:To investigate the levels of the triglyceride-glucose(TyG)index and sex hormone-binding globulin(SHBG)in patients with type 2 diabetes mellitus(T2DM)with diabetic retinopathy(DR),and to explore their correlations with biochemical parameters and the homeostasis model assessment of insulin resistance(HOMA-IR)in DR patients.METHODS:Patients with T2DM and healthy individuals were enrolled.Age and body mass index(BMI)of the participants were collected,TyG of the subjects was calculated using the formula,SHBG level of the subjects was detected,and blood biochemical indexes were measured at the same time.The changes of each index among the groups were statistically analyzed,and the relationship between TyG,SHBG,DR and each index was analyzed.RESULTS:A total of 150 patients with T2DM and 64 healthy individuals as normal controls(NC,28 males and 36 females,mean age 54.49±10.10y)were enrolled following ophthalmic evaluation.Patients were categorized into non-DR group(42 males and 36 females,mean age 56.68±8.02y)and DR group(35 males and 37 females,mean age,53.83±11.10y).TyG levels were significantly elevated in both non-DR(7.25±0.62)and DR groups(8.02±0.82)compared to controls(6.85±0.48),with the DR group demonstrating higher TyG values than the non-DR group(P<0.05).The level of SHBG(nmol/L)in DR group(25.05±14.06)was lower than that in control group(41.90±22.6)and non-DR group(36.27±20.00;P<0.05).TyG exhibited significant inverse correlations with SHBG(r=-0.455)and high density lipoprotein(HDL;r=-0.430)levels(P<0.05).It was positively correlated with BMI,fasting blood glucose(FBG),2h postprandial blood glucose(PBG),fasting C-peptide(FCP),glycated hemoglobin A1c(HbA1c),HOMA-IR,total cholesterol(TC)and triglycerides(TG)(r=0.406,0.768,0.386,0.393,0.475,0.250,0.242,0.888,respectively,P<0.05).SHBG was negatively correlated with BMI,FBG,FCP,HbA1c and TyG(r=-0.440,-0.304,-0.407,-0.209,-0.455,respectively,P<0.05),and positively correlated with age,TG and HDL(r=0.238,0.034,0.227,respectively,P<0.05).Further multiple regression analysis showed that SHBG was negatively correlated with TyG(P=0.006).CONCLUSION:Elevated TyG index,reduces SHBG levels,and their negative correlation in the DR group suggest potential roles of TyG and SHBG in the pathogenesis and progression of DR.Combined assessment of SHBG and TyG may provide valuable insights for DR prediction and diagnosis. 展开更多
关键词 diabetic retinopathy triglyceride-glucose index sex hormone binding globulin glycated hemoglobin insulin resistance index
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CORRIGENDUM 认领 引用
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作者 Min Zhang Xin-Rui Zhou +3 位作者 Wei-Guo Ma Xiao-Hong Yin Ya Li Rong Li 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2026年第7期1324-1324,共1页
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Accurate prediction of biliary atresia with an integrated model using MMP-7 levels and bile acids 认领 引用 被引量：5
3
作者 Yi-Jiang Han Shu-Qi Hu +10 位作者 Jin-Hang Zhu Xiao Cai Deng-Ming Lai Bao-Hai Chen Kun Zhu Qiao Tong Xin-Rui Zhou Jia-Le Deng Jin-Fa Tou Zhuo Fang Li-Zhong Du 《World Journal of Pediatrics》 SCIE CSCD 2024年第8期822-833,共12页
Background Biliary atresia(BA)is a rare fatal liver disease in children,and the aim of this study was to develop a method to diagnose BA early.Methods We determined serum levels of matrix metalloproteinase-7(MMP-7),th... Background Biliary atresia(BA)is a rare fatal liver disease in children,and the aim of this study was to develop a method to diagnose BA early.Methods We determined serum levels of matrix metalloproteinase-7(MMP-7),the results of 13 liver tests,and the levels of 20 bile acids,and integrated computational models were constructed to diagnose BA.Results Our findings demonstrated that MMP-7 expression levels,as well as the results of four liver tests and levels of ten bile acids,were significantly different between 86 BA and 59 non-BA patients(P<0.05).The computational prediction model revealed that MMP-7 levels alone had a higher predictive accuracy[area under the receiver operating characteristic curve(AUC)=0.966,95%confidence interval(CI):0.942,0.989]than liver test results and bile acid levels.The AUC was 0.890(95%CI 0.837,0.943)for liver test results and 0.825(95%CI 0.758,0.892)for bile acid levels.Furthermore,bile levels had a higher contribution to enhancing the predictive accuracy of MMP-7 levels(AUC=0.976,95%CI 0.953,1.000)than liver test results.The AUC was 0.983(95%CI 0.962,1.000)for MMP-7 levels combined with liver test results and bile acid levels.In addition,we found that MMP-7 levels were highly correlated with gamma-glutamyl transferase levels and the liver fibrosis score.Conclusion The innovative integrated models based on a large number of indicators provide a noninvasive and cost-effective approach for accurately diagnosing BA in children. 展开更多
关键词 Bile aid.Biliary atresia Diagnosis Liver fibrosis Liver test MMP-7
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