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Elucidating the anti-obesity phytochemicals in Chenpi and their molecular mechanisms 认领 引用
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作者 Jinhai Luo Weiqi Yan +1 位作者 Zhi Chen Baojun Xu 《Food Science and Human Wellness》 SCIE CAS CSCD 2025年第4期1224-1238,共15页
Obesity has become a significant global public health issue.Previous studies have found that the Chenpi has the anti-obesity activity.However,the anti-obesity phytochemicals and their mechanisms are still unclear.This... Obesity has become a significant global public health issue.Previous studies have found that the Chenpi has the anti-obesity activity.However,the anti-obesity phytochemicals and their mechanisms are still unclear.This study investigated the anti-obesity phytochemicals and molecular mechanisms involved in treating obesity by Chenpi through network pharmacology and molecular docking.A total of 17 bioactive phytochemicals from Chenpi and its 475 related anti-obesity targets have been identified.The KEGG pathway analysis showed that the PI3K/Akt signaling pathway,MAPK signaling pathway,AMPK signaling pathway,and nuclear factor kappa B signaling pathway are the main signaling pathways involved in the anti-obesity effect of Chenpi.According to molecular docking analysis,the phytochemicals of Chenpi can bind to central anti-obesity targets.Based on the ADMET analysis and network pharmacology results,tangeretin exhibited the lowest predicted toxicity and potential for anti-obesity effects.In the in vitro lipid accumulation model,tangeretin effectively suppressed the free fatty acid-induced lipid in Hep G2 cells by upregulating the PI3K/Akt/GSK3βsignaling pathway based on the result of q-PCR and Western blotting.The outcomes of this research give insights for future research on the anti-obesity phytochemicals and molecular mechanisms derived from Chenpi,also providing the theoretical basis for developing anti-obesity functional foods based on Chenpi. 展开更多
关键词 Chenpi Phytochemicals Obesity Network pharmacology Molecular mechanism Signaling pathway
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Xenopax for the treatment of steroid-refractory acute graft-versus-host disease:the RELAX study 认领 引用 被引量：6
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作者 Le-Qing Cao Wen-Xuan Huo +17 位作者 Er-Lie Jiang Yue-Wen Fu Xiao-Jun Xu Ping-Chong Lei Ming-Feng Zhao Zhi Chen Shu-Xia Guo Xiao-Bing Huang Yan-Ming Zhang Xian-Jing Wang Guan-Chen Bai Feng-Bo Jin Qing-Sheng Li Ming-Yang Deng Hao Zhang Xin-Feng Wang Xiao-Jun Huang Xiao-Dong Mo 《Military Medical Research》 SCIE CAS CSCD 2026年第3期400-412,共13页
Background:Steroid-refractory(SR)acute graft-versus-host disease(aGVHD)is the major cause of early mortality after allogeneic hematopoietic stem cell transplantation(allo-HSCT).Xenopax,a novel and the only available h... Background:Steroid-refractory(SR)acute graft-versus-host disease(aGVHD)is the major cause of early mortality after allogeneic hematopoietic stem cell transplantation(allo-HSCT).Xenopax,a novel and the only available humanized interleukin-2 receptor(IL-2R)antagonist,has been approved as a category 2 biological product by the National Medical Products Administration.This study aims to evaluate the efficacy,safety,and prognostic factors of xenopax treatment for SR-aGVHD in real-world settings.Methods:This was a multicenter,retrospective analysis that included SR-aGVHD patients who received xenopax at17 hospitals across China.The data were collected from the electronic medical records in transplant databases.The primary endpoint was the 28-day overall response rate(ORR),encompassing both partial and complete responses.This study also included independent historical SR-aGVHD cohorts treated with best available treatments(BATs,n=1009)as controls.Results:In total,172 SR-aGVHD patients were included in this study.Xenopax was administered either as monotherapy(n=60)or in combination with other second-line treatments(n=112).The ORR was 64.5%[95%confidence interval(CI)57.3-71.7]on day 28 and 82.6%(95%CI 76.9-88.3)at any time after xenopax treatment.The2-year probabilities of disease-free survival,overall survival,non-relapse mortality(NRM),and relapse after xenopax treatment were 57.0%(95%CI 49.9-65.0),68.0%(95%CI 61.4-75.4),24.2%(95%CI 18.0-30.9),and 19.0%(95%CI12.8-25.2),respectively.The ORR and survival were similar between patients with and without prior second-line treatments.The conditioning regimen and human leukocyte antigen disparity did not impact the efficacy of xenopax treatment.According to the multivariate analysis,the presence of gradeⅢ-ⅣaGVHD did not adversely affect the therapeutic response or survival.Xenopax also showed some superiority over BATs in historical cohorts.Conclusion:Our real-world findings suggest that xenopax is an effective and safe treatment for SR-aGVHD. 展开更多
关键词 Xenopax Acute graft-versus-host disease(aGVHD) Steroid refractory(SR) Allogeneic hematopoietic stem cell transplantation(allo-HSCT)
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Cuproptosis promotes inflammatory osteolysis via GYS1-mediated glycogen metabolism 认领 引用
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作者 Lu Zhou Hanqing Mao +2 位作者 Yuanhao Wen Zhi Chen Lu Zhang 《International Journal of Oral Science》 SCIE CAS CSCD 2026年第2期228-240,共13页
Copper,predominantly present in bones,plays a crucial role in bone formation.However,when copper homeostasis is disrupted,excessive copper can trigger harmful inflammation and a novel form of cell death known as cupro... Copper,predominantly present in bones,plays a crucial role in bone formation.However,when copper homeostasis is disrupted,excessive copper can trigger harmful inflammation and a novel form of cell death known as cuproptosis.The impact of cuproptosis on bone metabolism remains unclear.In this study,we demonstrated that excessive copper acts as an aggravator in osteoclastogenesis and bone resorption.We observed that the expression levels of the copper importer SLC31A1 and dihydrolipoamide S-acetyltransferase(DLAT)were positively correlated with bone loss in both human chronic apical periodontitis(CAP)tissues and mouse CAP models.Untargeted metabolomics analysis and screening of glucose metabolism enzymes revealed that glycogen synthesis was inhibited during cuproptosis.Mechanistically,excessive copper hindered glycogen synthesis via glycogen synthase 1(GYS1),which limited the availability of glycogenolysis-derived glucose-6-phosphate(G6P)flux into pentose phosphate pathway(PPP),and was unable to yield abundant NADPH to ensure high demand of glutathione(GSH)for macrophage survival.The inhibition of glycogen synthesis intensified cuproptosis and bone-resorption activity.Moreover,excessive copper bound to H3K27me3,which further epigenetically inhibited the gene transcription of GYS1,thereby affecting glycogen synthesis and exacerbating cuproptosis and bone resorption.Furthermore,the disruption of glycogen metabolism intensified cuproptosis and promoted inflammatory bone loss in vivo.Our finding highlighted the complex interplay among copper homeostasis,glycogen metabolism,and the osteo-immune system,suggesting new therapeutic strategies for managing inflammatory bone diseases and other copper accumulation-related conditions through the metabolic reprogramming of cells. 展开更多
关键词 bone metabolism cell death glucose phosphate osteoclastogenesis glycogen synthase cuproptosis bone resorption glycogen metabolism
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Exosomes in stroke management:A promising paradigm shift in stroke therapy 认领 引用
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作者 Bo Wang Pinzhen Chen +1 位作者 Wenyan Li Zhi Chen 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第1期6-22,共17页
Effective treatment methods for stroke,a common cerebrovascular disease with a high mortality rate,are still being sought.Exosome therapy,a form of acellular therapy,has demonstrated promising efficacy in various dise... Effective treatment methods for stroke,a common cerebrovascular disease with a high mortality rate,are still being sought.Exosome therapy,a form of acellular therapy,has demonstrated promising efficacy in various diseases in animal models;however,there is currently insufficient evidence to guide the clinical application of exosome in patients with stroke.This article reviews the progress of exosome applications in stroke treatment.It aims to elucidate the significant potential value of exosomes in stroke therapy and provide a reference for their clinical translation.At present,many studies on exosome-based therapies for stroke are actively underway.Regarding preclinical research,exosomes,as bioactive substances with diverse sources,currently favor stem cells as their origin.Due to their high plasticity,exosomes can be effectively modified through various physical,chemical,and genetic engineering methods to enhance their efficacy.In animal models of stroke,exosome therapy can reduce neuroinflammatory responses,alleviate oxidative stress damage,and inhibit programmed cell death.Additionally,exosomes can promote angiogenesis,repair and regenerate damaged white matter fiber bundles,and facilitate the migration and differentiation of neural stem cells,aiding the repair process.We also summarize new directions for the application of exosomes,specifically the exosome intervention through the ventricular-meningeal lymphatic system.The review findings suggest that the treatment paradigm for stroke is poised for transformation. 展开更多
关键词 angiogenesis animal model cerebrovascular disorder extracellular vesicle mortality rates neural stem cell neuroinflammation oxidative stress programmed cell death therapy
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Drought impacts on carbon fluxes in diverse warm temperate natural forests 认领 引用
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作者 Chongyu Yan Shirong Liu +4 位作者 Xiaodong Niu Zhi Chen Zhicheng chen Xiaojing Liu Guirui Yu 《Journal of Forestry Research》 SCIE EI CAS CSCD 2026年第1期10-22,共13页
Frequent droughts pose considerable threat to global forest carbon uptake,but little is known about the response of forest carbon fluxes in climatic transition zones to seasonal drought.In this study,the responses of ... Frequent droughts pose considerable threat to global forest carbon uptake,but little is known about the response of forest carbon fluxes in climatic transition zones to seasonal drought.In this study,the responses of carbon fluxes to seasonal drought in two natural forests(Quercus aliena var.acute serrata Maxim and Pinus tabuliformis Carr.)in the Baotianman Nature Reserve were investigated.The Q.aliena forest exhibited a high resilience with stable gross primary productivity(GPP).However,ecosystem respiration(Re)significantly declined by 18.4%compared with normal years,leading to an increase in net carbon sequestration capacity of 4.1%.This resilience was attributed to its deep root system accessing soil water(SWC50cm)to sustain stomatal openness,coupled with the efficient utilization of photosynthetically active radiation to drive photosynthesis.In contrast,the P.tabuliformis forest,which relied on shallow soil moisture(SWC20cm),experienced simultaneous decreases in both GPP and Re during drought,with a sharply greater decrease in GPP,resulting in low net carbon sink capacity.Further analysis revealed that the Q.aliena forest prioritized carbon assimilation through a deep water-stomatal synergy strategy(anisohydric behavior),whereas the P.tabuliformis forest adopted an isohydric strategy favoring water conservation at the expense of carbon fixation efficiency.These findings highlight distinct mechanisms underlying drought adaptation between forest types,providing critical insight into optimizing forest carbon cycle models and selecting drought-resistant species under the influence of climate change. 展开更多
关键词 Forest Carbon fluxes Eddy covariance Drought Resistance
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MARCH2 suppresses odontoblast differentiation by polyubiquitinating PTPRD 认领 引用 被引量：1
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作者 Hao Feng Jiaxin Niu +2 位作者 Zhi Chen Guobin Yang Guohua Yuan 《International Journal of Oral Science》 SCIE CAS CSCD 2026年第1期126-136,共11页
Dentin,the main component of dental hard tissues,is produced by differentiated odontoblasts.How odontoblast differentiation is regulated remains understudied.Here,we screen that the expression of membrane-associated R... Dentin,the main component of dental hard tissues,is produced by differentiated odontoblasts.How odontoblast differentiation is regulated remains understudied.Here,we screen that the expression of membrane-associated RING finger protein 2(March2) is the highest among all March family members,with an increasing trend during odontoblast differentiation.In mouse incisors and molars,MARCH2 is moderately expressed in the undifferentiated dental papilla cells and strongly expressed in the odontoblasts.Knockdown and overexpression experiments demonstrate that MARCH2 inhibits odontoblastic differentiation of mouse dental papilla cells(mDPCs).Additionally,both March2 deficient mice and mice with odontoblast specific knockdown of March2 exhibit the phenotype of increased dentin thickness,accelerated dentin deposition as well as elevated expression levels of odontoblast markers compared with control littermates.Therefore,MARCH2 plays an inhibitory role in odontoblast differentiation.Mechanistically,MARCH2 interacts with protein tyrosine phosphatase receptor delta(PTPRD) and facilitates its K27-linked polyubiquitination and subsequent degradation,which is dependent on the ligase activity of MARCH2.The presence of MARCH2promotes the translocation of PTPRD from the cell membrane to the lysosome,thereby enhancing its degradation via the lysosomal pathway.Further experiments show that knockdown of endogenous Ptprd impairs odontoblastic differentiation of mDPCs.Ptprd and March2 double knockdown in mDPCs apparently reversed the enhanced odontoblastic differentiation by knockdown of March2 alone,indicating that MARCH2 inhibits odontoblastic differentiation by promoting PTPRD degradation.This study unveils a novel mechanism where an E3 ubiquitin ligase regulates odontoblast differentiation through post-translational modification of a membrane protein,highlighting a promising direction for future exploration. 展开更多
关键词 membrane protein degradation undifferentiated dental papilla cells dental hard tissues polyubiquitination dental hard tissuesis Ptprd March mouse incisors
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Synergistic anion-dipole interaction enhances high-voltage stability across bulk electrolyte and electrode interphase 认领 引用
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作者 Cun Wang Yongxin Huang +6 位作者 Zhi Chen Xianggui Zhou Taifeng Ding Shihao Zhang Li Li Feng Wu Renjie Chen 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2026年第6期457-467,I0012,共11页
Although high-voltage systems offer higher energy density and lower energy loss,unstable electrolytes and interfaces hinder their practical application.Sulfur-containing compounds are often employed as effective elect... Although high-voltage systems offer higher energy density and lower energy loss,unstable electrolytes and interfaces hinder their practical application.Sulfur-containing compounds are often employed as effective electrolyte additives to improve high-voltage performance;however,their underlying mechanisms remain insufficiently understood.To elucidate how sulfur-containing compounds enhance highvoltage behavior,we performed high-throughput screening of 163 sulfur-containing molecules and identified two key features associated with high performance in high-voltage systems:a high intrinsic oxidation potential and a strong anion-dipole interaction.Prop-1-ene-1,3-sultone(PES),which has strong anion affinity,was used as a model to investigate interactions with solvent molecules and anions in both bulk electrolyte and electrode interfaces.In bulk,PES suppresses the hydrolysis of PF6-and hydrogen transfer of ethylene carbonate(EC)by forming strong interactions with both EC and PF6-,thereby significantly enhancing oxidative stability.At interfaces,PES preferentially adsorbs and facilitates PF6--enrichment via anion-dipole interaction.This effect lowers PF6-oxidation potential and promotes its preferential decomposition during CEI formation,yielding a stable,Li F-rich interphase.In a PES-modified low-concentration electrolyte,Li||Li Mn2O4cells retain 72.7%capacity after 500 cycles at 3–4.8 V,and Gr||Li Mn2O4pouch cells retain 60.0%at 60℃over 200 cycles.By establishing structure–activity relationships between molecular-level interactions and battery performance,this work proposes an innovative strategy and corresponding filtering criteria for engineering high-voltage electrolytes in advanced energy storage systems. 展开更多
关键词 Lithium-ion batteries High-throughput screening Anion-dipole interaction Sulfur-containing compounds High-voltage electrolyte
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Spectroscopic signature of the anchoring effect of anions in lithium salts with MIL-100(Al)open metal sites 认领 引用
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作者 Meizhu E Caiyan He +6 位作者 Yifan Xing Fangjie Ji Zhi Chen Kaiqin Yang Bin Jiang Jiwen Feng Shenhui Li 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2026年第7期533-542,I0013,共10页
Metal-organic frameworks(MOFs)with open metal sites(OMSs)in quasi-solid-state electrolytes(QSSEs)can effectively enhance the ionic transport,increase the lithium-ion transference number,stabilize the electrode/electro... Metal-organic frameworks(MOFs)with open metal sites(OMSs)in quasi-solid-state electrolytes(QSSEs)can effectively enhance the ionic transport,increase the lithium-ion transference number,stabilize the electrode/electrolyte interface,and suppress dendrite formation.These effects are frequently attributed to the anchoring of lithium-salt anions on the unsaturated metal sites in MOFs.However,the detailed interactions between anions and MOFs,as well as the dynamic behavior of anchored anions in QSSEs,have not yet been well understood at the atomic and molecular levels.Herein,versatile solid-state NMR spectroscopy was employed to investigate the anchoring effects of anions on the open Al3+sites in MIL-100(Al)-based QSSEs.19F-27Al RESPDOR and 2D 19F-27Al D-HMQC NMR experiments provide direct experimental evidence for host–guest interactions between lithium-salt anions and the open metal sites in MIL-100(Al).Partially restricted motion,rather than complete immobilization,of the anions induced by the anchoring effect is elucidated by 19F-11B RESPDOR and 19F-31P REDOR experiments.Electrochemical tests demonstrate that the MIL-100(Al)-based QSSE exhibits superior Li+transport and interfacial stability compared with the MOF-free counterpart,delivering a Li+transference number(tLi)of 0.39,an electrochemical stability window of up to 5.2 V,and stable lithium plating/stripping in Li||Li symmetric cells for over 1000 h at 0.1 mA cm-2.The open Al3+sites in MIL-100(Al)efficiently modulate anion behavior to facilitate Li salt dissociation,enhance Li+transport selectivity,and reinforce interfacial stability with lithium metal,thereby inhibiting dendrite growth.This study deepens the fundamental understanding of the anion-OMSs interactions in MOF-based QSSEs. 展开更多
关键词 Quasi-solid-state electrolytes Lithium batteries Metal-organic frameworks Solid-state NMR Host-guest interaction
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CDK4 Mediates Cisplatin Resistance in Renal Cell Carcinoma(RCC)Cells by Regulating the ASH1L-CTR1 Axis 认领 引用
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作者 Wenjian Zeng Xianglong Li +5 位作者 Hao Cai Qingyu Zhou Shuangshuang Sun Pingping Li Sunlong Li Zhi Chen 《Oncology Research》 SCIE 2026年第6期660-697,共38页
Objectives:Cisplatin resistance is a major obstacle in the treatment of renal cell carcinoma(RCC),severely compromising therapeutic efficacy and patient prognosis.This study aimed to clarify the role and molecular mec... Objectives:Cisplatin resistance is a major obstacle in the treatment of renal cell carcinoma(RCC),severely compromising therapeutic efficacy and patient prognosis.This study aimed to clarify the role and molecular mechanism of cyclin-dependent kinase 4(CDK4)in cisplatin resistance of RCC.Methods:Immunohistochemistry(IHC)was used to detect the expression of CDK4 in cisplatin-resistant RCC tissues.In RCC cells and their drug-resistant sublines,CDK4 overexpression/knockdown assays were performed to evaluate the effects on cisplatin resistance and malignant progression.An in vivo model was established,to verify the in vivo function of CDK4.Transcriptome sequencing(RNA-seq),Cleavage Under Targets and Tagmentation(CUT&Tag),chromatin immunoprecipitation(ChIP)and dual-luciferase reporter assays were applied to elucidate the downstream regulatory mechanism of CDK4.Results:CDK4 was highly expressed in Tumor-Drug Resistant(Tumor-DR)tissues,which was significantly correlated with poor patient prognosis.CDK4 overexpression enhanced cisplatin resistance and malignant phenotypes of RCC cells,whereas CDK4 knockdown reversed these effects and sensitized cells to cisplatin.In vivo experiments confirmed that CDK4 promoted cisplatin resistance and tumor growth of A498 cells,and this effect was validated under both CIS and GEM intervention.Mechanistically,CDK4 directly bound to the promoter region of the ASH1L(ASH1-Like Histone Lysine Methyltransferase)gene to promote its transcription;by upregulating ASH1L,CDK4 inhibited the expression of copper transporter 1(CTR1),thereby mediating cisplatin resistance.Targeted inhibition of CDK4 or ASH1L enhanced the cisplatin sensitivity of RCC cells.Conclusions:This study identifies the critical role of the CDK4-ASH1L-CTR1 axis in cisplatin resistance of RCC. 展开更多
关键词 Renal cell carcinoma cisplatin resistance cyclin-dependent kinase 4(CDK4) ASH1-Like Histone Lysine Methyltransferase(ASH1L) copper transporter 1(CTR1) molecular mechanism
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Associations of black coffee and black coffee supplemented with milk with diabetes in China:A community-based cross-sectional study 认领 引用
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作者 Yi Zeng Pei-Yi Li +7 位作者 Zhi Chen Nan-Fang Yao Hong Ye Zi-Hao Gui Hua-Lan Chen Lan Liu Heng Wan Jie Shen 《World Journal of Diabetes》 SCIE 2026年第3期116-126,共11页
BACKGROUND Coffee consumption exhibits significant geographical variation between coffee and diabetes between China and Western countries.Furthermore,existing research on the relationship between coffee consumption an... BACKGROUND Coffee consumption exhibits significant geographical variation between coffee and diabetes between China and Western countries.Furthermore,existing research on the relationship between coffee consumption and diabetes yields inconsistent results,with limited studies focusing on the Chinese population.AIM To investigate the association among coffee consumption,diabetes,and glucose indices among Chinese adults.METHODS A cross-sectional survey,involving 6876 individuals from the communities,was conducted in Guangdong,China.Participants provided detailed records of their coffee consumption,including any additives such as milk,sugar,or artificial sweeteners.Diabetic indicators measured included glycated hemoglobin(HbA1c),fasting plasma glucose,and 2-hour postprandial glucose(2h-PG).Statistical analyses were performed using multivariable logistic regression,adjusting for three categories of covariates:Demographic and anthropometric characteristics,lifestyle factors,and clinical and family history indicators.RESULTS In the adjusted model,coffee consumption was found to be inversely associated with the prevalence of diabetes,with an odds ratio(OR)of 0.79 and a 95%confidence interval(CI)of 0.64 to 0.98(P=0.029).Additionally,higher coffee consumption was inversely associated with elevated 2h-PG levels(OR=0.83,95%CI:0.73-0.95;P=0.005).Among individuals who consumed coffee with milk,the odds of elevated 2h-PG levels were reduced by 24%(OR=0.76,95%CI:0.66-0.88;P<0.001),and the odds of elevated HbA1c levels were reduced by 28%(OR=0.72,95%CI:0.63-0.83;P<0.001).CONCLUSION Coffee consumption,particularly the intake of coffee with milk,is inversely associated with the prevalence of diabetes,elevated 2h-PG,and increased HbA1c levels.The intake of coffee with milk is a factor of interest in the context of diabetes prevention or glycemic control;however,this observation necessitates further validation through additional randomized controlled trials. 展开更多
关键词 Diabetes mellitus Coffee Fasting blood glucose Glycated hemoglobin Blood glucose management Milk
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Intelligent near-to-mid-infrared ultrafast fiber lasers with particle swarm-optimized graphene electro-optic modulators 认领 引用
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作者 Shuo Sun Qi Kang +8 位作者 Wenkai Wang Yimiao Chen Yule Zhang Xilin Tian Huide Wang Yanqi Ge Zhi Chen Qiao Wen Han Zhang 《Advanced Photonics Nexus》 CSCD 2026年第5期92-102,共11页
Ultrafast fiber lasers,as core light sources for precision manufacturing,biomedicine,and quantum communication,have long been constrained in performance optimization by complex nonlinear dynamics,environmental sensiti... Ultrafast fiber lasers,as core light sources for precision manufacturing,biomedicine,and quantum communication,have long been constrained in performance optimization by complex nonlinear dynamics,environmental sensitivity,and insufficient tuning flexibility.The integration of artificial intelligence(AI)and cutting-edge electro-optic modulation materials offers a transformative paradigm to overcome these bottlenecks.By leveraging the Fermi level tuning property of graphene and embedding the particle swarm optimization(PSO)algorithm,we developed an intelligent electro-optic modulation device that enables closedloop dynamic control of ultrafast fiber lasers at 1.5 and 2.8μm.Through closed-loop optimization by the particle swarm algorithm,rapid self-starting and termination of pulse states,as well as programmable and reversible control of pulse width,repetition rate,and output power were achieved.In addition,our system can automatically identify and resolve pulse splitting caused by external disturbances.We establish broadband intelligent electro-absorption in the near-to-mid infrared spectral range,laying the technical foundation for broadband infrared photonics in the 1–3μm range. 展开更多
关键词 AI-optimized tunable fiber laser broadband infrared photonics graphene electro-optic modulator
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Near-field channel estimation for movable antenna systems via bidirectional movement 认领 引用
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作者 Shun Yang Weidong Mei +2 位作者 Xin Wei Zhi Chen Boyu Ning 《Intelligent and Converged Networks》 EI 2026年第2期183-193,共11页
Movable antenna(MA)systems have emerged as a transformative approach in the area of wireless communications by enabling dynamic antenna repositioning within a local region.However,to achieve a high design flexibility,... Movable antenna(MA)systems have emerged as a transformative approach in the area of wireless communications by enabling dynamic antenna repositioning within a local region.However,to achieve a high design flexibility,a sufficiently large movement region is generally required,which,however,introduces complex spherical wavefront effects.As such,this paper focuses on the near-field channel estimation problem for MA systems,aiming to acquire the channel state information at any position within the antenna movement region under the near-field field-response channel model.To this end,we propose a novel bidirectional movement strategy for joint estimation of both angular and distance parameters of multi-path components.Under this strategy,we develop an adaptive grid orthogonal matching pursuit algorithm that leverages geometric constraints between the bidirectional movement to resolve parameter ambiguities and mitigate grid mismatch effects.The algorithm incorporates adaptive refinement mechanisms,hierarchical search strategies,and convergence monitoring to ensure reliable parameter estimation.Simulation results demonstrate that the proposed approach significantly improves the parameter estimation accuracy in terms of normalized mean square error compared with conventional methods,particularly in the low signal-to-noise ratio regime. 展开更多
关键词 movable antenna(MA) near-field communications channel estimation compressed sensing orthogonal matching pursuit
机动卫勤分队队员在生物防御任务中核心能力的质性研究 认领 引用
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作者 曹堇沫 支晨 +1 位作者 罗屹惟 马慧 《解放军医学院学报》 CAS 2026年第3期247-251,285,共5页
背景国内生物安全威胁增多,目前针对机动卫勤分队队员在生物防御任务中核心能力的相关研究有限。目的探讨机动卫勤分队队员在生物防御任务中的核心能力,为制订系统、科学、完整的能力培养路径提供参考依据和思路。方法2025年4—5月采用... 背景国内生物安全威胁增多,目前针对机动卫勤分队队员在生物防御任务中核心能力的相关研究有限。目的探讨机动卫勤分队队员在生物防御任务中的核心能力,为制订系统、科学、完整的能力培养路径提供参考依据和思路。方法2025年4—5月采用目的抽样法选取6所军队医学院校的21名人员针对机动卫勤分队队员在生物防御任务中核心能力进行半结构式访谈,基于模块化理论、主题分析法对访谈资料进行分析和提炼主题。结果生物防御任务中核心能力可归纳为3个主题模块及11个亚主题模块。第一模块为基础职业能力,涵盖应急响应能力、团队协作能力、心理调适能力、环境适应能力。第二模块为生物防御专项胜任力,包括生物安全专业知识与技能、生物防御现场资源管理与优化能力、生物污染伤员医疗后送的协调与管控能力、生物安全事件模拟与实战演练中救护处置能力。第三模块为技术集成与专业发展,涉及人工智能前沿技术应用能力、信息技术协作与资源共享能力、持续学习与岗位专业发展能力。结论本研究基于模块化理论,提炼生物安全防御任务核心能力要素,具备独立性与可重组性,可为机动卫勤分队队员在“平战结合、快速响应”任务背景下模块化编组与精准化培养提供理论框架。 展开更多
关键词 生物安全 模块化理论 卫勤保障 生物防御 机动卫勤分队 核心能力 质性研究
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Expert consensus on management of instrument separation in root canal therapy 认领 引用 被引量：6
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作者 Yi Fan Yuan Gao +33 位作者 Xiangzhu Wang Bing Fan Zhi Chen Qing Yu Ming Xue Xiaoyan Wang Zhengwei Huang Deqin Yang Zhengmei Lin Yihuai Pan Jin Zhao Jinhua Yu Zhuo Chen Sijing Xie He Yuan Kehua Que Shuang Pan Xiaojing Huang Jun Luo Xiuping Meng Jin Zhang Yi Du Lei Zhang Hong Li Wenxia Chen Jiayuan Wu Xin Xu Jing Zou Jiyao Li Dingming Huang Lei Cheng Tiemei Wang Benxiang Hou Xuedong Zhou 《International Journal of Oral Science》 SCIE CAS CSCD 2025年第3期301-313,共13页
Instrument separation is a critical complication during root canal therapy,impacting treatment success and long-term tooth preservation.The etiology of instrument separation is multifactorial,involving the intricate a... Instrument separation is a critical complication during root canal therapy,impacting treatment success and long-term tooth preservation.The etiology of instrument separation is multifactorial,involving the intricate anatomy of the root canal system,instrument-related factors,and instrumentation techniques.Instrument separation can hinder thorough cleaning,shaping,and obturation of the root canal,posing challenges to successful treatment outcomes.Although retrieval of separated instrument is often feasible,it carries risks including perforation,excessive removal of tooth structure and root fractures.Effective management of separated instruments requires a comprehensive understanding of the contributing factors,meticulous preoperative assessment,and precise evaluation of the retrieval difficulty.The application of appropriate retrieval techniques is essential to minimize complications and optimize clinical outcomes.The current manuscript provides a framework for understanding the causes,risk factors,and clinical management principles of instrument separation.By integrating effective strategies,endodontists can enhance decision-making,improve endodontic treatment success and ensure the preservation of natural dentition. 展开更多
关键词 root canal therapy instrument separation retrieval techniques tooth preservation root canal therapyimpacting endodontic treatment success root canal root canalposing
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Expert consensus on pulpotomy in the management of mature permanent teeth with pulpitis 认领 引用 被引量：5
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作者 Lu Zhang Chen Lin +30 位作者 Zhuo Chen Lin Yue Qing Yu Benxiang Hou Junqi Ling Jingping Liang Xi Wei Wenxia Chen Lihong Qiu Jiyao Li Yumei Niu Zhengmei Lin Lei Cheng Wenxi He Xiaoyan Wang Dingming Huang Zhengwei Huang Weidong Niu Qi Zhang Chen Zhang Deqin Yang Jinhua Yu Jin Zhao Yihuai Pan Jingzhi Ma Shuli Deng Xiaoli Xie Xiuping Meng Jian Yang Xuedong Zhou Zhi Chen 《International Journal of Oral Science》 SCIE CAS CSCD 2025年第2期147-154,共8页
Pulpotomy,which belongs to vital pulp therapy,has become a strategy for managing pulpitis in recent decades.This minimally invasive treatment reflects the recognition of preserving healthy dental pulp and optimizing l... Pulpotomy,which belongs to vital pulp therapy,has become a strategy for managing pulpitis in recent decades.This minimally invasive treatment reflects the recognition of preserving healthy dental pulp and optimizing long-term patient-centered outcomes.Pulpotomy is categorized into partial pulpotomy(PP),the removal of a partial segment of the coronal pulp tissue,and full pulpotomy(FP),the removal of whole coronal pulp,which is followed by applying the biomaterials onto the remaining pulp tissue and ultimately restoring the tooth.Procedural decisions for the amount of pulp tissue removal or retention depend on the diagnostic of pulp vitality,the overall treatment plan,the patient’s general health status,and pulp inflammation reassessment during operation.This statement represents the consensus of an expert committee convened by the Society of Cariology and Endodontics,Chinese Stomatological Association.It addresses the current evidence to support the application of pulpotomy as a potential alternative to root canal treatment(RCT)on mature permanent teeth with pulpitis from a biological basis,the development of capping biomaterial,and the diagnostic considerations to evidence-based medicine.This expert statement intends to provide a clinical protocol of pulpotomy,which facilitates practitioners in choosing the optimal procedure and increasing their confidence in this rapidly evolving field. 展开更多
关键词 pulpotomy partial pulpotomy pp partial pulpotomy minimally invasive treatment applying biomaterials vital pulp therapyhas coronal pulpwhich full pulpotomy fp
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High-concentration single-atom Zn-doped porous tubular g-C3N4:a superior photocatalyst for tetracycline hydrochloride degradation and bacterial sterilization 认领 引用 被引量：5
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作者 Chunyan Li Yuxing Cai +9 位作者 Jianhao Wu Lan Li Sa-Sa Xia Xiaozhuo Wang Rongrong Jia Zhi Chen Cheng-Chao Jin Wen Wang Rongyan Wang Nan Zhang 《Rare Metals》 SCIE EI CAS CSCD 2025年第7期4756-4766,共11页
High-concentration single-atom doping remains a formidable challenge due to the propensity for single atoms to form clusters or aggregate at elevated concentrations.Herein,high-concentration (10.8 wt%) Zn singleatom-d... High-concentration single-atom doping remains a formidable challenge due to the propensity for single atoms to form clusters or aggregate at elevated concentrations.Herein,high-concentration (10.8 wt%) Zn singleatom-doped porous tubular g-C3N4(ZCN) was successfully obtained via a template-free,one-step calcination method,exhibiting excellent photocatalytic performance.The confinement of the pore walls suppresses the Zn atom'smigration and aggregation,enhancing the Zn single-atom stability.ZCN exhibited excellent photodegradation performance against tetracycline with outstanding stability.Moreover,ZCN displayed remarkable sterilization performance,achieving a 100%inactivation of Staphylococcus aureus within 90 min of visible-light exposure.Density functional theory calculations demonstrated that the Zn single-atom sites act as pivotal photocatalytic active sites,with the presence of Zn single atoms notably augmenting charge separation efficiency.This work provides a novel approach for managing photocatalytic efficiency through enlarging single-atom doping,offering an avenue for pollutant photodegradation and sterilization. 展开更多
关键词 Photocatalysis Zn single atoms Porous tubular g-C3N4 Degradation of pollutants Sterilization
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Expert consensus on apical microsurgery 认领 引用 被引量：6
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作者 Hanguo Wang Xin Xu +34 位作者 Zhuan Bian Jingping Liang Zhi Chen Benxiang Hou Lihong Qiu Wenxia Chen Xi Wei Kaijin Hu Qintao Wang Zuhua Wang Jiyao Li Dingming Huang Xiaoyan Wang Zhengwei Huang Liuyan Meng Chen Zhang Fangfang Xie Di Yang Jinhua Yu Jin Zhao Yihuai Pan Shuang Pan Deqin Yang Weidong Niu Qi Zhang Shuli Deng Jingzhi Ma Xiuping Meng Jian Yang Jiayuan Wu Yi Du Junqi Ling Lin Yue Xuedong Zhou Qing Yu 《International Journal of Oral Science》 SCIE CAS CSCD 2025年第1期1-9,共9页
Apical microsurgery is accurate and minimally invasive,produces few complications,and has a success rate of more than 90%.However,due to the lack of awareness and understanding of apical microsurgery by dental general... Apical microsurgery is accurate and minimally invasive,produces few complications,and has a success rate of more than 90%.However,due to the lack of awareness and understanding of apical microsurgery by dental general practitioners and even endodontists,many clinical problems remain to be overcome.The consensus has gathered well-known domestic experts to hold a series of special discussions and reached the consensus.This document specifies the indications,contraindications,preoperative preparations,operational procedures,complication prevention measures,and efficacy evaluation of apical microsurgery and is applicable to dentists who perform apical microsurgery after systematic training. 展开更多
关键词 microsurgery prevention overcome
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Ultra-small cesium silver bismuth bromide quantum dots fabricated by modified hot-injection method for highly efficient degradation of contaminants in organic solvent 认领 引用 被引量：2
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作者 Jianhao Wu Xiaozhuo Wang +7 位作者 Jinglei Hu Chunyan Li Linpu Shi Sa-Sa Xia Yuxing Cai Rongrong Jia Zhi Chen Lan Li 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2025年第6期577-583,共7页
Lead-free halide perovskite material has drawn fast-growing interest due to its superiorsolar-conversion efficiency and nontoxic nature. In this work, we have successfully fabricatedcesium silver bismuth bromide (Cs2A... Lead-free halide perovskite material has drawn fast-growing interest due to its superiorsolar-conversion efficiency and nontoxic nature. In this work, we have successfully fabricatedcesium silver bismuth bromide (Cs2AgBiBr6) quantum dots utilizing the hot injectionmethod. The as-synthesized quantum dots were characterized by combined techniques,which showed remarkable visible-light photocatalytic activity for organic dyes and antibioticdegradation in ethanol. Specifically, about 97% of rhodamine B and methyl orange maybe removed within 10 min and 30 min, respectively. Additionally, 60% of antibiotic residueof tetracycline hydrochloride is degraded in 30min which is 7 times more than that on commercialtitania (P25). The reactive species for the photodegradation are determined throughcapture experiments, and a reaction mechanism is proposed accordingly. This work providesa novel photocatalyst for the selective removal of diverse organic contaminants inethanol and an alternative for the potential application of lead-free halide perovskites. 展开更多
关键词 Cs2AgBiBr6 quantum dots Photocatalysis of nonlead halide perovskite Photodegradation in organic solvent Organic dye removal Antibiotic residue treatment
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Trichostatin A augments cell migration and epithelial-mesenchymal transition in esophageal squamous cell carcinoma through BRD4/c- Myc endoplasmic reticulum-stress pathway 认领 引用 被引量：2
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作者 Yan-Min Chen Wen-Qian Yang +3 位作者 Ying-Ying Fan Zhi Chen Yu-Zhen Liu Bao-Sheng Zhao 《World Journal of Gastroenterology》 SCIE CAS 2025年第11期164-182,共19页
BACKGROUND The causes of death in patients with advanced esophageal cancer are multi-factorial,with tumor metastasis being one of the important factors.Histone acetylation promotes the migration of esophageal squamous... BACKGROUND The causes of death in patients with advanced esophageal cancer are multi-factorial,with tumor metastasis being one of the important factors.Histone acetylation promotes the migration of esophageal squamous cell carcinoma(ESCC)cells,while the histone deacetylase inhibitor(HDACi)shows complex effects on tumor functions.AIM To comprehensively elucidate the impact and molecular mechanisms of trichostatin A(TSA),an HDACi,on cell migration in ESCC through bromodomain-containing protein(BRD4)/cellular myelocytomatosis oncogene(c-Myc)/endoplasmic reticulum(ER)-stress.METHODS The effects of TSA on ESCC cell lines Eca109 and EC9706 migration were evaluated using Transwell assays,with small interfering transfection and pathway-specific inhibitors to elucidate underlying mechanisms.The mRNA levels involved were examined by quantitative real-time polymerase chain reaction.Protein levels of acetylated histones H3(acH3)and acetylated histones H4,BRD4,c-Myc,as well as markers of ER stress and epithelial-mesenchymal transition(EMT),were analyzed using western blot.Additionally,this method was also used to examine acH3 levels in esophageal cancer tissues and adjacent tissues.Patient outcomes were subsequently tracked to identify prognostic indicators using Log-Rank tests and Cox multivariate analysis.RESULTS TSA promoted the migration of ESCC cells by stimulating the EMT process.TSA-mediated histone acetylation facilitated the recruitment of BRD4,a bromodomain-containing protein,triggering the expression of c-Myc.This cascade induced ER stress and enhanced EMT in ESCC cells.To further elucidate the underlying mechanism,we employed various interventions including the ER stress inhibitor 4-phenylbutyric acid,knockdown of c-Myc and BRD4 expression,and utilization of the BRD4 inhibitor carboxylic acid as well as the inhibitor of TSA 1.Mechanist-ically,these studies revealed that TSA-mediated histone acetylation facilitated the recruitment of BRD4,which in turn triggered the expression of c-Myc.This sequential activation induced ER stress and subsequently enhanced EMT,thereby promoting the migration of ESCC cells.Additionally,we examined histone acetylation levels in specimens from 43 patients with ESCC,including both tumor tissues and paired adjacent tissues.Statistical analysis unveiled a negative correlation between the level of histone acetylation and the long-term prognosis of patients with ESCC.CONCLUSION TSA promoted ESCC cell migration through the BRD4/c-Myc/ER stress pathway.Moreover,elevated histone acetylation in ESCC tissues correlated with poor ESCC prognosis.These findings enhance our understanding of ESCC migration and HDACi therapy. 展开更多
关键词 Esophageal squamous cell carcinoma Histone deacetylase inhibitor Trichostatin A Endoplasmic reticulum stress Epithelial-mesenchymal transition Cell migration
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Expert consensus on intentional tooth replantation 认领 引用 被引量：1
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作者 Zhengmei Lin Dingming Huang +31 位作者 Shuheng Huang Zhi Chen Qing Yu Benxiang Hou Lihong Qiu Wenxia Chen Jiyao Li Xiaoyan Wang Zhengwei Huang Jinhua Yu Jin Zhao Yihuai Pan Shuang Pan Deqin Yang Weidong Niu Qi Zhang Shuli Deng Jingzhi Ma Xiuping Meng Jian Yang Jiayuan Wu Lan Zhang Jin Zhang Xiaoli Xie Jinpu Chu Kehua Que Xuejun Ge Xiaojing Huang Zhe Ma Lin Yue Xuedong Zhou Junqi Ling 《International Journal of Oral Science》 SCIE CAS CSCD 2025年第4期477-486,共10页
Intentional tooth replantation(ITR)is an advanced treatment modality and the procedure of last resort for preserving teeth with inaccessible endodontic or resorptive lesions.ITR is defined as the deliberate extraction... Intentional tooth replantation(ITR)is an advanced treatment modality and the procedure of last resort for preserving teeth with inaccessible endodontic or resorptive lesions.ITR is defined as the deliberate extraction of a tooth;evaluation of the root surface,endodontic manipulation,and repair;and placement of the tooth back into its original socket.Case reports,case series,cohort studies,and randomized controlled trials have demonstrated the efficacy of ITR in the retention of natural teeth that are untreatable or difficult to manage with root canal treatment or endodontic microsurgery.However,variations in clinical protocols for ITR exist due to the empirical nature of the original protocols and rapid advancements in the field of oral biology and dental materials.This heterogeneity in protocols may cause confusion among dental practitioners;therefore,guidelines and considerations for ITR should be explicated.This expert consensus discusses the biological foundation of ITR,the available clinical protocols and current status of ITR in treating teeth with refractory apical periodontitis or anatomical aberration,and the main complications of this treatment,aiming to refine the clinical management of ITR in accordance with the progress of basic research and clinical studies;the findings suggest that ITR may become a more consistent evidence-based option in dental treatment. 展开更多
关键词 deliberate extraction toothevaluation root surfaceendodontic manipulationand intentional tooth replantation intentional tooth replantation itr advanced treatment modality retention natural teeth endodontic resorptive lesionsitr randomized controlled trials preserving teeth
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