Objective This study aimed to investigate pregnancy outcomes after conservative treatment for severe postpartum hemorrhage(PPH)following cesarean delivery(CD).Methods A total of 9,366 women who underwent CD for two co...Objective This study aimed to investigate pregnancy outcomes after conservative treatment for severe postpartum hemorrhage(PPH)following cesarean delivery(CD).Methods A total of 9,366 women who underwent CD for two consecutive pregnancies were included.Bakri balloon tamponade was employed in 87 women,and compression sutures were used in 87 women to control PPH during the first CD.The subsequent pregnancy outcomes and operative findings during the second CD were compared among the groups.Results The preterm delivery rate was 3.2%in the control group,12.6%in the Bakri group,and 11.5%in the compression suture group(P<0.001).The rates of placenta accreta(1.4%vs.1.3%vs.5.3%,P=0.017),PPH(0.9%vs.3.9%vs.8.0%,P<0.001),and pelvic adhesions(5.2%vs.6.5%vs.13.3%,P=0.004)were significantly greater in the compression suture group.After adjustment,conservative treatment increased the rate of preterm birth in subsequent pregnancies threefold.A compression suture increased the risk of placenta accreta by four fold and the incidence of pelvic adhesions by more than two fold in subsequent CD.Conclusions Conservative treatment for PPH following CD is associated with an increased risk of subsequent preterm birth.Women receiving compression sutures have an increased risk of placenta accreta and pelvic adhesions in subsequent pregnancies.展开更多
目的探讨缩宫素联合垂体后叶素对宫缩乏力性产后出血患者纤溶、凝血功能的影响。方法便利抽样法选取2019年1月至2023年8月宫缩乏力性产后出血患者52例,按照随机数字表发分组即对照组和观察组,每组均26例,对照组使用缩宫素治疗,研究组采...目的探讨缩宫素联合垂体后叶素对宫缩乏力性产后出血患者纤溶、凝血功能的影响。方法便利抽样法选取2019年1月至2023年8月宫缩乏力性产后出血患者52例,按照随机数字表发分组即对照组和观察组,每组均26例,对照组使用缩宫素治疗,研究组采用缩宫素联合垂体后叶素的治疗方案,统计两组产后出血量、凝血功能指标、临床疗效、不良反应。结果观察组产后2h出血量(238.24±36.25 mL vs 279.32±42.71mL,t=3.739,P=0.001)、产后24h出血量(569.23±28.15mL vs 621.22±41.33mL,t=5.301,P<0.001)均显著低于对照组,且止血时间更短(21.11±3.22min vs 29.23±3.61min,t=8.559,P<0.001)。治疗后,观察组凝血酶时间(TT)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、D-二聚体(D-D)及纤维蛋白原(Fib)的改善差值均显著高于对照组(均P<0.001)。观察组临床总有效率为96.15%(25/26),显著高于对照组的76.92%(20/26)(χ2=4.127,P=0.042)。两组不良反应总发生率比较,差异无统计学意义(23.08%vs15.38%,χ2=0.495,P=0.482)。结论对于宫缩乏力性产后出血患者,在缩宫素基础上联合应用垂体后叶素,能更有效地减少产后出血量、缩短止血时间,并显著改善患者的纤溶与凝血功能,临床疗效确切,且未显著增加不良反应,安全性良好。展开更多
目的:探讨宫腔球囊压迫联合缩宫素在高危型前置胎盘剖宫产术中预防产后出血的临床效果。方法:采用随机对照试验,选取2022年1月至2025年1月南阳市中心医院产科收治的82例高危型前置胎盘患者,随机分为对照组(n=41,单纯缩宫素治疗)和观察组...目的:探讨宫腔球囊压迫联合缩宫素在高危型前置胎盘剖宫产术中预防产后出血的临床效果。方法:采用随机对照试验,选取2022年1月至2025年1月南阳市中心医院产科收治的82例高危型前置胎盘患者,随机分为对照组(n=41,单纯缩宫素治疗)和观察组(n=41,缩宫素联合宫腔球囊压迫术)。比较两组术中及术后出血量、血红蛋白变化、产后出血发生率及不良反应。结果:观察组术中出血量(856.34±198.72 m L vs 1285.67±243.89 m L,P<0.001)、术后24 h出血量(156.23±48.91 m L vs 298.56±72.84 m L,P<0.001)显著低于对照组;产后出血发生率(19.51% vs 56.10%,P<0.001)明显降低;术后24 h时血红蛋白水平(106.74±14.26 g/L vs 92.35±12.89 g/L,P<0.001)更高。两组不良反应发生率无显著差异(4.88%vs 4.88%,P=1.000)。结论:宫腔球囊压迫联合缩宫素可有效减少高危型前置胎盘剖宫产术中及术后出血,降低产后出血发生率,且安全性良好。展开更多
基金supported by the Shanghai Municipal Commission of Health and Family Planning Regular Project(No.201740043)the National Natural Science Foundation(No.81771600)the Clinical Research Plan of SHDC(No.SHDC2020CR2059B)。
摘要Objective This study aimed to investigate pregnancy outcomes after conservative treatment for severe postpartum hemorrhage(PPH)following cesarean delivery(CD).Methods A total of 9,366 women who underwent CD for two consecutive pregnancies were included.Bakri balloon tamponade was employed in 87 women,and compression sutures were used in 87 women to control PPH during the first CD.The subsequent pregnancy outcomes and operative findings during the second CD were compared among the groups.Results The preterm delivery rate was 3.2%in the control group,12.6%in the Bakri group,and 11.5%in the compression suture group(P<0.001).The rates of placenta accreta(1.4%vs.1.3%vs.5.3%,P=0.017),PPH(0.9%vs.3.9%vs.8.0%,P<0.001),and pelvic adhesions(5.2%vs.6.5%vs.13.3%,P=0.004)were significantly greater in the compression suture group.After adjustment,conservative treatment increased the rate of preterm birth in subsequent pregnancies threefold.A compression suture increased the risk of placenta accreta by four fold and the incidence of pelvic adhesions by more than two fold in subsequent CD.Conclusions Conservative treatment for PPH following CD is associated with an increased risk of subsequent preterm birth.Women receiving compression sutures have an increased risk of placenta accreta and pelvic adhesions in subsequent pregnancies.
摘要目的探讨缩宫素联合垂体后叶素对宫缩乏力性产后出血患者纤溶、凝血功能的影响。方法便利抽样法选取2019年1月至2023年8月宫缩乏力性产后出血患者52例,按照随机数字表发分组即对照组和观察组,每组均26例,对照组使用缩宫素治疗,研究组采用缩宫素联合垂体后叶素的治疗方案,统计两组产后出血量、凝血功能指标、临床疗效、不良反应。结果观察组产后2h出血量(238.24±36.25 mL vs 279.32±42.71mL,t=3.739,P=0.001)、产后24h出血量(569.23±28.15mL vs 621.22±41.33mL,t=5.301,P<0.001)均显著低于对照组,且止血时间更短(21.11±3.22min vs 29.23±3.61min,t=8.559,P<0.001)。治疗后,观察组凝血酶时间(TT)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、D-二聚体(D-D)及纤维蛋白原(Fib)的改善差值均显著高于对照组(均P<0.001)。观察组临床总有效率为96.15%(25/26),显著高于对照组的76.92%(20/26)(χ2=4.127,P=0.042)。两组不良反应总发生率比较,差异无统计学意义(23.08%vs15.38%,χ2=0.495,P=0.482)。结论对于宫缩乏力性产后出血患者,在缩宫素基础上联合应用垂体后叶素,能更有效地减少产后出血量、缩短止血时间,并显著改善患者的纤溶与凝血功能,临床疗效确切,且未显著增加不良反应,安全性良好。
摘要目的:探讨宫腔球囊压迫联合缩宫素在高危型前置胎盘剖宫产术中预防产后出血的临床效果。方法:采用随机对照试验,选取2022年1月至2025年1月南阳市中心医院产科收治的82例高危型前置胎盘患者,随机分为对照组(n=41,单纯缩宫素治疗)和观察组(n=41,缩宫素联合宫腔球囊压迫术)。比较两组术中及术后出血量、血红蛋白变化、产后出血发生率及不良反应。结果:观察组术中出血量(856.34±198.72 m L vs 1285.67±243.89 m L,P<0.001)、术后24 h出血量(156.23±48.91 m L vs 298.56±72.84 m L,P<0.001)显著低于对照组;产后出血发生率(19.51% vs 56.10%,P<0.001)明显降低;术后24 h时血红蛋白水平(106.74±14.26 g/L vs 92.35±12.89 g/L,P<0.001)更高。两组不良反应发生率无显著差异(4.88%vs 4.88%,P=1.000)。结论:宫腔球囊压迫联合缩宫素可有效减少高危型前置胎盘剖宫产术中及术后出血,降低产后出血发生率,且安全性良好。