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Research progress on the characteristics and essence of meridians and acupoints from an interdisciplinary perspective:A review 认领 引用
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作者 Yu-pei Cheng Yang Guo +4 位作者 Can Wang Bang-qi Wu Qing Xia Run-chen Zhang Yi Guo 《Journal of Integrative Medicine》 SCIE CAS CSCD 2026年第1期33-48,共16页
This study summarizes and discusses the characteristics and essence of meridians and acupoints from the perspectives of physics,chemistry and biology.An extensive body of literature from Pub Med and the China National... This study summarizes and discusses the characteristics and essence of meridians and acupoints from the perspectives of physics,chemistry and biology.An extensive body of literature from Pub Med and the China National Knowledge Infrastructure was reviewed and categorized into three distinct groups:physical characteristics-related research(75 articles),which examined electrical,thermal,optical,acoustic and magnetic properties,and isotope migration;chemical characteristics-related literature(44 articles),focusing on chemical ions,oxygen partial pressure,nitric oxide and substance P;and biological essencerelated research(52 articles),which primarily explored microcirculation,extracellular fluid channels,mast cells,telocytes,connexins,hilum of muscle and bone,and sensory nerve fibers.Current research emphasizes the electrical and thermal properties of the meridians and acupoints,whereas investigations into the essence of meridians are increasingly shifting from macroscopic to microscopic structures.It is essential to fully harness the advantages of interdisciplinary integration,which could significantly advance our understanding and applications in the realm of acupuncture and traditional medicine. 展开更多
关键词 Acupuncture Meridians Acupoints Physical properties Chemical properties Biological essence
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Distribution characteristics of somatic hyperalgesic acupoints in patients with functional dyspepsia:A case-control study 认领 引用
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作者 Yuan-bo GAO Xue-song WANG +7 位作者 Xu-xin LI Peng-an XIANG Jing-yi JIAO Bing-xian LI Jun-cha ZHANG Jun LIU Xi-sheng FAN Yan-fen SHE 《World Journal of Acupuncture-Moxibustion》 CAS CSCD 2026年第2期178-188,共11页
Objective To investigate the distribution characteristics of somatic hyperalgesic acupoints in patients with functional dyspepsia(FD),at the same time,the receiver operating characteristic(ROC)curve was used with heal... Objective To investigate the distribution characteristics of somatic hyperalgesic acupoints in patients with functional dyspepsia(FD),at the same time,the receiver operating characteristic(ROC)curve was used with healthy subjects to evaluate the distribution characteristics of hyperalgesic acupoints,and summarize the objective rule of acupoint hyperalgesia in patients with FD,aiming to provide objective evidence for the acupoint sensitization theory and the scientific basis for optimizing acupoint selection strategies of acupuncture for FD.Methods A case-control study design was adopted with 40 patients with FD(FD group)and 38 healthy subjects(control group).The pressure pain threshold(PPT)and pain tolerance threshold(PTT)of acupoints on the abdomen,lumbar region,and lower limbs were measured by a pressure pain tester in both groups.The differences between the two groups were analyzed by statistical analysis,and the diagnostic efficacy of the sensitized acupoints was evaluated by ROC curve.Results(1)The PPT in the FD group was lower than that in the control group at Tianshu(ST25)(Right:10.8 v.s.12.6,P=0.049)and Sanyinjiao(SP6)(Right:16.3 v.s.19.1,P=0.023),respectively.(2)Compared with the control group,the PTT in the FD group was lower at Zhongwan(CV12)(22.8 v.s.28.6,P=0.002),Tianshu(ST25)(Left:22.0 v.s.28.2,P=0.001.Right:22.6 v.s.27.3,P=0.016),Zusanli(ST36)(Left:21.3 v.s.26.6,P=0.007.Right:51.8 v.s.57.6,P=0.030),Shangjuxu(ST37)(Left:46.0 v.s.52.7,P=0.034.Right:46.6 v.s.58.4,P=0.009),Xiajuxu(ST39)(Left:44.9 v.s.54.1,P=0.021.Right:44.8 v.s.55.6,P=0.006),Yinlingquan(SP9)(Left:31.6 v.s.44.1,P=0.001.Right:33.5 v.s.42.8,P=0.003),Sanyinjiao(SP6)(Left:33.8 v.s.43.7,P=0.015.Right:33.6 v.s.41.5,P=0.013),and Xiaochangshu(BL27)(Left:41.9 v.s.52.8,P=0.007.Right:46.5 v.s.55.2,P=0.038)separately.(3)The diagnostic efficacy of left Yinlingquan(SP9)was the best(AUC=0.72,95%CI:0.61 to 0.83,P<0.001),and the optimal cutoff value was<44.Zhongwan(CV12)(AUC=0.68)on the abdomen and left Tianshu(ST25)(AUC=0.69)and right Xiajuxu(ST39)(AUC=0.67)on the lower limbs,and the left Xiaochangshu(BL27)(AUC=0.68)on the back all demonstrated the moderate diagnostic efficacy(AUC:0.67 to 0.69).Furthermore,except for the PPT at the right Tianshu(ST25)(P=0.17)and the PTT at the right Xiaochangshu(BL27)(P=0.05),the results of ROC analysis for all the other acupoints showed statistical significance(P<0.05),suggesting that the sensitization of these acupoints may be valuable potentially for the diagnosis of FD.Conclusion Patients with FD exhibit an objectively quantifiable hyperalgesic phenomenon,primarily characterized by a reduced PTT.The distribution of sensitized acupoints follows“horizontal distribution of acupoints”and“longitudinal division of meridians”,which may provide a scientific basis for acupoint selection in acupuncture for FD. 展开更多
关键词 Functional dyspepsia(FD) Hyperalgesia Acupoint sensitization ROC curve Pressure algometer
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The Specificity of Electroacupuncture at Different Acupoints in Promoting Cerebrospinal Fluid Flow in Mice 认领 引用
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作者 SHI Yu HUA Qian +4 位作者 PENG Tian-Tian NIE Yu-Xin LIU Zhao-Heng DENG Chen-Geng WANG Xu 《生物化学与生物物理进展》 SCIE CAS CSCD 北大核心 2026年第5期1154-1164,共11页
Objective Cerebrospinal fluid(CSF)plays a crucial role in maintaining the homeostasis of the central nervous system(CNS).CSF rapidly exchanges with interstitial fluid(ISF)via the glymphatic system within the brain par... Objective Cerebrospinal fluid(CSF)plays a crucial role in maintaining the homeostasis of the central nervous system(CNS).CSF rapidly exchanges with interstitial fluid(ISF)via the glymphatic system within the brain parenchyma.CSF-ISF circulation and its associated mechanisms are often referred to as the brain lymphatic system.This system is connected directly to meningeal lymphatic vessels(mLVs),jointly performing the function of clearing metabolic waste from the CNS.Emerging evidence indicates that this system is closely associated with the onset and progression of neurodegenerative diseases(NDs)such as Alzheimer’s disease(AD).Importantly,abnormal CSF circulation is not only a downstream consequence of AD pathology,but also a risk factor.In AD,the dynamics of CSF flow within the CNS are diminished,immune dysregulation occurs,and this may increase the risk of AD by exacerbating the burden of amyloidβ-protein(Aβ).In the mouse model of AD,impaired CSF flow compromises this clearance function,leading to cognitive deficits.Clinically,acupuncture at cognition-related acupoints is commonly used for the prevention and treatment of AD.However,whether its therapeutic effects are mediated through the modulation of CSF dynamics remains unclear.This study aimed to evaluate the impact of acupuncture on CSF flow and investigate its acupoint specificity.Methods Mice were randomly assigned to experimental groups for the different electroacupuncture groups with the following acupoints:Baihui point(GV 20),Ear point,Neiguan point(PC 6),and Tianshu point(ST 25).Wild-type mice on a C57BL/6J background were used as controls.Fluorescent tracer was injected into the cisterna magna to label CSF flow.Fluorescence imaging was employed to assess the distribution of CSF within the brain before and after acupuncture stimulation.Results Following tracer injection into the cisterna magna,fluorescence signals rapidly reached the cerebellum and medulla—the regions closest to the injection site.Fluorescence intensity was higher in ventral brain regions compared to dorsal regions,likely due to greater vascular density in ventral areas facilitating CSF-ISF exchange.Electroacupuncture at the GV 20 produced the most pronounced enhancement of CSF across the whole brain,while stimulation at the ST 25 primarily augmented flow within subcortical regions.In contrast,electroacupuncture at the Ear point or the PC 6 had no observable effect on CSF in mice.Conclusion Electroacupuncture promotes CSF flow into the brain parenchyma in an acupoint-specific manner,with GV 20 exhibiting the most pronounced enhancement of CSF dynamics.These findings suggest that acupuncture-mediated facilitation of CSF flow may represent a potential therapeutic strategy for preventing or delaying age-related cognitive decline. 展开更多
关键词 cerebrospinal fluid CSF-ISF electroacupuncture acupoint specificity
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Does acupuncture at motor-related acupoints affect corticospinal excitability?A systematic review and meta-analysis 认领 引用 被引量：1
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作者 Renming Liu Aung Aung Kywe Moe +2 位作者 Weiting Liu Maryam Zoghi Shapour Jaberzadeh 《Journal of Integrative Medicine》 SCIE CAS CSCD 2025年第2期113-125,共13页
Background:Acupuncture is widely used in modulating brain excitability and motor function,as a form of complementary and alternative medicine.However,there is no existing meta-analysis evaluating the effectiveness and... Background:Acupuncture is widely used in modulating brain excitability and motor function,as a form of complementary and alternative medicine.However,there is no existing meta-analysis evaluating the effectiveness and safety of acupuncture on corticospinal excitability(CSE),and the credibility of the evidence has yet to be quantified.Objective:This study was designed to assess the efficacy and safety of electroacupuncture(EA)and manual acupuncture(MA)in enhancing brain excitability,specifically focusing on CSE as measured by transcranial magnetic stimulation(TMS).Search strategy:This study followed a systematic approach,searching 9 databases up to August 2024 and examining grey literature,in compliance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.Inclusion criteria:Studies were included if they compared the clinical efficacy of EA or MA with sham acupuncture,no treatment or usual training.Data extraction and analysis:Three investigators independently conducted literature screening,data extraction,and risk of bias assessment.The primary outcome focused on motor-evoked potentials as measured by TMS,with treatment effects quantified using mean differences or standardized mean differences between pre-and post-treatment.Subgroup analyses were conducted using mixed-effects models,while random-effects or fixed-effects models were used to estimate average treatment differences across studies.Results:Based on 34 studies involving 1031 adults,acupuncture techniques significantly enhanced CSE.EA had a greater impact than MA,with effect sizes of 0.53 mV vs 0.43 mV(95%confidence interval[CI]:[0.30,0.76],P<0.00001 vs 95%CI:[0.28,0.59],P<0.00001).The 5 most frequently used acupoints were LI4(Hegu,32 times),ST36(Zusanli,10 times),LI11(Quchi,7 times),TE5(Waiguan,6 times),and GB34(Yanglingquan,5 times).Conclusion:This systematic review indicates that both EA and MA could effectively and safely enhance CSE,bringing the corticospinal pathway closer to the threshold for firing,which may ultimately improve motor function.LI4,ST36,LI11,TE5 and GB34 are the most commonly used acupoints. 展开更多
关键词 Acupuncture Brain excitability Corticospinal excitability Motor-related acupoints Motor function
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Mechanistic insights into“Three Methods and Three Acupoints”Tuina therapy for improving spinal microcirculation and motor function in sciatic nerve injury model rats 认领 引用 被引量：1
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作者 Hanyu Zhang Yingqi Zhang +6 位作者 Hourong Wang Jiayue Liu Jiawei Sun Jinping Chen Zhifeng Liu Tianyuan Yu Jian Shu 《Journal of Traditional Chinese Medical Sciences》 CAS CSCD 2025年第1期125-134,共10页
Objective:To investigate the effects of“Three Methods and Three Acupoints”(TMTP)Tuina therapy on spinal microcirculation in sciatic nerve injury(SNI).Methods:Thirty-six SpragueeDawley rats were randomly assigned to ... Objective:To investigate the effects of“Three Methods and Three Acupoints”(TMTP)Tuina therapy on spinal microcirculation in sciatic nerve injury(SNI).Methods:Thirty-six SpragueeDawley rats were randomly assigned to four groups:normal,sham operation,model,and TMTP Tuina.Successful model induction was confirmed by observable hind limb lameness.After 20 sessions,hind limb grip strength and motor nerve conduction velocity(MNCV)were measured at baseline and following the 10th and 20th intervention.CD31 and a-SMA in the ventral horn of SNI model rats were detected using immunofluorescence.Motor neurons in the ventral horn were detected by Nissl staining.PTEN levels in the ventral horn were measured by ELISA,and PI3K,Akt,BDNF,VEGF,and HIF-1a expression was determined by RT-PCR.Spinal cord microcirculation was evaluated by western blotting analysis of the levels of Akt,p-Akt,BDNF,and VEGF.Results:Hind limb grip strength and MNCV significantly improved in the TMTP Tuina group compared to the model group(both P<.001).Morphology of ventral horn motor neurons in the TMTP Tuina group improved compared to the model group,with increased expressions of a-SMA(P=.002)and CD31(P=.006).Western blot analysis indicated increased expression of VEGF(P=.005),p-Akt(P<.001),and BDNF(P=.008)in the ventral horn following Tuina treatment.RT-PCR analysis revealed increased expression of PI3K,Akt,BDNF,VEGF and HIF-1a(all P<.05).In contrast,expression of PTEN decreased compared to the model group(P<.001).Conclusion:TMTP Tuina therapy may restore motor function in rats,enhance ventral horn motor neuron morphology,and promote angiogenesis and vascular smooth muscle proliferation.The mechanism may involve the activation of the PI3K/Akt signaling pathway. 展开更多
关键词 Three Methods and Three Acupoints Tuina Spinal cord Microcirculation PI3K/Akt
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Mechanisms of acupuncture at Zusanli(ST36)and its combinational acupoints for stress gastric ulcer based on the correlation between Zang-fu and acupoints 认领 引用 被引量：7
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作者 Mu He Xue Yee Lim +2 位作者 Jing Li Ling Li Tong Zhang 《Journal of Integrative Medicine》 SCIE CAS CSCD 2025年第1期1-11,共11页
Gastric ulcer(GU)is a common digestive system disease.Acupuncture,as one of the external treatments of traditional Chinese medicine(TCM),has the characteristics of multi-target,multi-pathway and multi-level action in ... Gastric ulcer(GU)is a common digestive system disease.Acupuncture,as one of the external treatments of traditional Chinese medicine(TCM),has the characteristics of multi-target,multi-pathway and multi-level action in the treatment of GU.The relationship between meridian points and Zang-fu is an important part of the theory of TCM,which is crucial for the diagnosis and treatment of diseases.There is an external and internal link between acupoints and Zang-fu.The pathological reaction of Zang-fu can manifest as acupoint sensitization,while stimulation of acupoints can play a therapeutic role in the internal Zang-fu.Therefore,the acupoint has the functions of reflecting and treating diseases.This review explores the tender points on the body surface of patients with GU and the rules of acupoint selection.In addition,Zusanli(ST36),as one of the most used acupoints of the stomach meridian,was selected to show the mechanisms behind acupoint stimulation in the treatment of GU in greater detail,specifically in the well-studied model of the stress GU(SGU).Hence,the mechanisms of acupuncture at ST36 and points commonly used in combination with ST36 to treat SGU are discussed further.Treatment effects can be achieved through anti-inflammatory and antioxidant activities,gastric mucosal injury repair,and interaction with the brain-gut axis.In summary,this review provides evidence for a comprehensive understanding of the phenomena and mechanism of acupoint functions for GU. 展开更多
关键词 Acupuncture Gastric ulcer Stress gastric ulcer Acupoint function Mechanism
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Thermal sensitization of acupoints in patients with knee osteoarthritis:A cross-sectional case-control study 认领 引用 被引量：1
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作者 Jian-feng Tu Xue-zhou Wang +9 位作者 Shi-yan Yan Yi-ran Wang Jing-wen Yang Guang-xia Shi Wen-zheng Zhang Li-na Jin Li-sha Yang Dong-hua Liu Li-qiong Wang Bao-hong Mi 《Journal of Integrative Medicine》 SCIE CAS CSCD 2025年第3期289-296,共8页
Objective:Varied acupoint selections represent a potential cause of the uncertainty surrounding the efficacy of acupuncture for knee osteoarthritis(OA).Skin temperature,a guiding factor for acupoint selection,may help... Objective:Varied acupoint selections represent a potential cause of the uncertainty surrounding the efficacy of acupuncture for knee osteoarthritis(OA).Skin temperature,a guiding factor for acupoint selection,may help to address this issue.This study explored thermal sensitization of acupoints used for the treatment of knee OA.Methods:This cross-sectional case-control study enrolled cases aged 45–75 years with symptomatic knee OA and age-and gender-matched non-knee OA controls in a 1:1 ratio.All participants underwent infrared thermographic imaging.The primary outcome was the relative skin temperature of acupoint(STA),and the secondary outcome was the absolute STA of 11 acupoints.The Z test was used to compare the relative and absolute STAs between the groups.Principal component analysis was used to extract the common factors(CFs,acupoint cluster)in the STAs.A general linear model was used to identify factors affecting the STA in the knee OA cases.For the group comparisons of relative STA,P<0.0045(adjusted for 11 acupoints through Bonferroni correction)was considered to indicate statistical significance.For other analyses,P<0.05 was used as the threshold for statistical significance.Results:The analysis included 308 participants,consisting of 151 cases(mean age:[64.58±6.67]years;male:25.83%;mean body mass index:[25.70±3.16]kg/m~2)and 157 controls(mean age:[63.37±5.96]years;male:26.11%;mean body mass index:[24.47±2.84]kg/m~2).The relative STAs of ST34(P=0.0001),EX-LE2(P<0.0001),EX-LE5(P=0.0006),SP10(P<0.0001),BL40(P=0.0012)and GB39(P=0.0037)were higher in the knee OA group.No difference was found in the STAs of ST35,ST36,SP9,GB33 and GB34.Four CFs were identified for relative STA in both groups.The acupoints within each CF were consistent between the groups.The mean values of the relative STAs across each CF were higher in the knee OA group.In the knee OA cases,no factors were observed to affect the relative STA,while age and gender were found to affect the absolute STA.Conclusion:Among patients with knee OA,thermal sensitization occurs in the acupoints of the lower extremity,exhibiting localized and regional thermal consistencies.The thermally sensitized acupoints that we identified in this study,ST34,SP10,EX-LE2,EX-LE5,GB39 and BL40,may be good choices for the acupuncture treatment of knee OA. 展开更多
关键词 Knee osteoarthritis Acupuncture Acupoint Thermography Skin temperature
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Irritable bowel syndrome with diarrhea (IBS-D) treated with moxibustion on heat-sensitive acupoints: a randomized controlled trial 认领 引用 被引量：13
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作者 胡丹 康明非 +1 位作者 熊俊 邓鹏 《World Journal of Acupuncture-Moxibustion》 CAS 2012年第2期1-5,共5页
Objective To compare the effects between acupuncture combined with moxibustion on heat-sensitive acupoints and acupuncture on irritable bowel syndrome with diarrhea （IBS-D）. Methods Sixty-four cases were randomly di... Objective To compare the effects between acupuncture combined with moxibustion on heat-sensitive acupoints and acupuncture on irritable bowel syndrome with diarrhea （IBS-D）. Methods Sixty-four cases were randomly divided into an acupuncture and moxibustion group （n=32） and an acupuncture group （n=32）. Conventional acupuncture at Tiānshū （天枢 ST 14）, Zúsānlǐ （足三里 ST 36）, Gōngsūn （公孙 SP 4） and other acupoints was used in the two groups, and moxibustion on heat-sensitive acupoints was added in the acupuncture and moxibustion group. The treatment frequency was 5 times a week, and 4 weeks were a course. After 2 courses, the therapeutic effect was evaluated. Results The clinical symptom scores after treatment in two groups decreased obviously than those before treatment （both P〈0.01）. The cured and markedly effective rate in the acupuncture and moxibustion group was 87.5% （28/32）, and that in the acupuncture group was 37.5% （12/32）, so the effect in the acupuncture and moxibustion group was better than that in the acupuncture group （P〈0.01）. The improvement of all kinds of symptom scores in the acupuncture and moxibustion group was all better than that in the acupuncture group （all P〈0.05）. Conclusion The clinical effect of acupuncture combined with moxibustion on heat-sensitive acupoints on IBS-D is better than that of acupuncture. 展开更多
关键词 heat-sensitive acupoints irritable bowel syndrome with diarrhea moxibustion on heat-sensitive acupoints acupuncture therapy randomized controlled trial
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Improvement in acupoint selection for acupuncture of nerves surrounding the injury site: electro-acupuncture with Governor vessel with local meridian acupoints 认领 引用 被引量：14
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作者 Guan-heng He Jing-wen Ruan +3 位作者 Yuan-shan Zeng Xin Zhou Ying Ding Guang-hui Zhou 《Neural Regeneration Research》 SCIE CAS CSCD 2015年第1期128-135,共8页
Peripheral nerve injury not only affects the site of the injury, but can also induce neuronal apop- tosis at the spinal cord. However, many acupuncture clinicians still focus only on the injury site, selecting acupoin... Peripheral nerve injury not only affects the site of the injury, but can also induce neuronal apop- tosis at the spinal cord. However, many acupuncture clinicians still focus only on the injury site, selecting acupoints entirely along the injured nerve trunk and neglecting other regions; this may delay onset of treatment efficacy and rehabilitation. Therefore, in the present study, we compared the clinical efficacy of acupuncture at Governor vessel and local meridian acupoints combined （GV/LM group） with acupuncture at local meridian acupoints alone （LM group） in the treatment of patients with peripheral nerve injury. In the GV/LM group （n = 15）, in addition to meridian acupoints at the injury site, the following acupoints on the Governor vessel were stimulated： Baihui （GV20）, Fengfu （GV16）, Dazhui （GV14）, and Shenzhu （GV12）, selected to treat nerve injury of the upper limb, and Jizhong （GV6）, Mingmen （GV4）, Yaoyangguan （GV3）, and Yaoshu （GV2） to treat nerve injury of the lower limb. In the LM group （n = 15）, only me- ridian acupoints along the injured nerve were selected. Both groups had electroacupuncture treatment for 30 minutes, once a day, 5 times per week, for 6 weeks. Two cases dropped out of the LM group. A good or excellent clinical response was obtained in 80% of the patients in the GV/ LM group and 38.5% of the LM group. In a second study, an additional 20 patients underwent acupuncture with the same prescription as the GV/LM group. Electomyographic nerve conduc- tion tests were performed before and after acupuncture to explore the mechanism of action of the treatment. An effective response was observed in 80.0% of the patients, with greater motor nerve conduction velocity and amplitude after treatment, indicating that electroacupuncture on specific Governor vessel acupoints promotes functional motor nerve repair after peripheral nerve injury. In addition, electromyography was performed before, during and after electroacu- puncture in one patient with radial nerve injury. After a single session, the patient＇s motor nerve conduction velocity increased by 23.2%, indicating that electroacupuncture at Governor vessel acupoints has an immediate therapeutic effect on peripheral nerve injury. Our results indicate that Governor vessel and local meridian acupoints used simultaneously promote functional repair after peripheral nerve injury. The mechanism of action may arise from an improvement of the local microenvironment in injured nervous tissue, as well as immediate effects of Governor vessel and local meridian acupoint stimulation to ensure the continuity between the peripheral and central nervous systems. 展开更多
关键词 nerve regeneration peripheral nerve injury acupuncture electroacupuncture Governorvessel acupoints local acupoints eleetrophysiology spinal cord motor nerve conduction functionalrepair neural regeneration
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An infrared thermographic analysis of the sensitization acupoints of women with primary dysmenorrhea 认领 引用 被引量：11
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作者 FAN Xisheng DU Xiaoyi +8 位作者 PAN Lijia SONG Xiaodan LIU Jun ZHANG Juncha CHEN Hao GAO Yayu ZHANG Mingjian SHI Xuliang SHE Yanfen 《Journal of Traditional Chinese Medicine》 SCIE CSCD 2022年第5期825-832,共8页
OBJECTIVE:To explore the sensitization acupoints of women with primary dysmenorrhea(PD)by comparing infrared radiation temperatures between acupoints and non-acupoints.METHODS:We tested 10 acupoints of every woman wit... OBJECTIVE:To explore the sensitization acupoints of women with primary dysmenorrhea(PD)by comparing infrared radiation temperatures between acupoints and non-acupoints.METHODS:We tested 10 acupoints of every woman with PD and healthy subjects on premenstrual,menstrual,and postmenstrual days using an infrared imaging device.The primary outcome was the absolute value of body surface temperature difference(AVTD)between the left and right sides of the same testing point.RESULTS:A total of 58 PD patients and 57 healthy volunteers completed the test from May 2016 to May 2017.Compared with the healthy group,we observed a significant reduction and increase in the AVTD in Taichong(LR3)and Sanyinjiao(SP6),respectively,during menstrual days in the PD group(P=0.01;P=0.04);while during postmenstrual days,all AVTDs of Shuiquan(KI5),Diji(SP8),and Xuehai(SP10)were diminished in the PD group(P=0.01;P=0.03;P=0.01,respectively).No significant differences in AVTD were detected at any other points or testing times.CONCLUSIONS:Compared with the healthy group,the AVTDs of Taichong(LR3),Sanyinjiao(SP6),Shuiquan(KI5),Diji(SP8),and Xuehai(SP10)at menstruationrelevant points of PD patients were sensitized,providing a reference for the selection of acupoints in the treatment of PD. 展开更多
关键词 dysmenorrhea menstruation infrared thermal imaging acupoint sensitization specific acupoints
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Catgut implantation at acupoints increases the expression of glutamate aspartate transporter and glial glutamate transporter-1 in the brain of rats with spasticity after stroke 认领 引用 被引量：13
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作者 Rui-Qing Li Ming-Yue Wan +7 位作者 Jing Shi Hui-Ling Wang Fei-Lai Liu Cheng-Mei Liu Jin Huang Ren-Chao Liu Le Ma Xiao-Dong Feng 《Neural Regeneration Research》 SCIE CAS CSCD 2018年第6期1013-1018,共6页
Catgut implantation at acupoints has been shown to alleviate spasticity after stroke in rats.However,the underlying mechanisms are poorly understood.In this study,we used the rat middle cerebral artery occlusion model... Catgut implantation at acupoints has been shown to alleviate spasticity after stroke in rats.However,the underlying mechanisms are poorly understood.In this study,we used the rat middle cerebral artery occlusion model of stroke.Three days after surgery,absorbable surgical catgut sutures were implanted at Dazhui（GV14）,Jizhong（GV6）,Houhui,Guanyuan（CV4）and Zhongwan（CV12）.The Zea Longa score was used to assess neurological function.The Modified Ashworth Scale was used to evaluate muscle tension.The 2,3,5-triphenyl-tetrazolium chloride assay was used to measure infarct volume.Immunohistochemical staining was performed for glutamate aspartate transporter（GLAST）and glial glutamate transporter-1（GLT-1）expression.Western blot assay was used to analyze the expression of GLAST and GLT-1.Reverse transcription and polymerase chain reaction were carried out to assess the expression of GLAST and GLT-1m RNAs.After catgut implantation at the acupoints,neurological function was substantially improved,muscle tension was decreased,and infarct volume was reduced in rats with spasticity after stroke.Furthermore,the expression of GLAST and GLT-1 m RNAs was increased on the injured（left）side.Our findings demonstrate that catgut implantation at acupoints alleviates spasticity after stroke,likely by increasing the expression of GLAST and GLT-1. 展开更多
关键词 nerve regeneration stroke Dazhui （GV14） lizhong （GV6） Houhui Guanyuan （CV4） Zhongwan （CV12） catgut implantation at acupoints limb spasm glutamate transporter neural regeneration
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Effect of electroacupuncture at ear and body acupoints on the instant fasting blood glucose level of machins with type 2 diabetes mellitus 认领 引用 被引量：7
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作者 赵敬军 翟煦 +4 位作者 罗曼 贲卉 荣培晶 王树兴 梁远成 《World Journal of Acupuncture-Moxibustion》 CAS CSCD 2016年第1期19-23,共5页
Objective To observe the effect of electroacupuncture at ear and body acupoints for the instant fasting blood glucose of model machins with type 2 diabetes mellitus（T2DM）.Methods For 10 machins with type2 diabetes,t... Objective To observe the effect of electroacupuncture at ear and body acupoints for the instant fasting blood glucose of model machins with type 2 diabetes mellitus（T2DM）.Methods For 10 machins with type2 diabetes,the electroacupuncture was applied at ＂Zusanli＂（足三里 ST 36）,＂Sanyinjiao＂（三阴交 SP 6） and three ＂Jiangtangdian＂（降糖点） in the ear continuously for 5 days,with the frequency of 2/15 Hz（The 2 Hz and the 15 Hz were transferred every second） and current of2 mA.The treatment was given once every day for 30 min.The fasting blood glucose was measured before acupuncture,after acupuncture for15 min and 30 min in the 5 days.Results On the first day,after 30-minute acupuncture the fasting blood glucose was reduced obviously compared with that before treatment（P〈0.01）.On the third and the fifth days,after acupuncture for 15 min and 30 min the fasting blood glucose was apparently lower than that before acupuncture（all P〈0.05）.On the fourth day,after acupuncture for 30 min the fasting blood glucose was decreased markedly than that before acupuncture（P〈0.05）.After 30-minute acupuncture on the fifth day,the fasting blood glucose was lower obviously than that before treatment on the first day（P〈0.05）.Conclusion ①The electroacupuncture at ear and body acupoints can reduce the instant fasting blood glucose of T2 DM machins apparently.② There is time effect on instant fasting blood glucose of T2 DM machins treated by electroacupuncture.The efficacy of 30-minute stimulation is superior to that of 15-minute acupuncture.After acupuncture continuously for 4 days,the effect is better than that with acupuncture for3 days successively. 展开更多
关键词 electroacupuncture ear points body acupoints type 2 diabetes mellitus fasting blood glucose instant
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Electroacupuncture at facial acupoints combined with electrical stimulation on the auricular vagus nerve points for 60 cases of chloasma 认领 引用 被引量：5
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作者 Shike ZHANG Hui HE +1 位作者 Yong LIU Weibin GAO 《World Journal of Acupuncture-Moxibustion》 CAS CSCD 2018年第2期55-57,84,共3页
Objective： To observe the clinical efficacy of electroacupuncture at facial acupoints combined with electrical stimulation on the auricular vagus nerve points for treatment of chloasma.Methods： Sixty patients with c... Objective： To observe the clinical efficacy of electroacupuncture at facial acupoints combined with electrical stimulation on the auricular vagus nerve points for treatment of chloasma.Methods： Sixty patients with chloasma were selected. According to acupoint selection along facial nerve trunk initially created by professor Gao Wei-bin, Yifeng（翳风TE 17）, Shangguan（上关GB 3） Sizhukong（丝竹空 TE 23）,temporal branches, Xiaguan（下关 ST 7） Sibai（四白 ST 2）,zygomatic branches, Qianzheng（牵正）Quanliao（颧髎 SI 18）,zygomatic branches, Jiache（颊车 ST 6） Chengjiang（承浆 CV 24）,buccal branches, and Hegu（合谷 LI 4）. The auricular vagus nerve acupoints was added additionally（two distribution points in each cavity of auricular concha were selected）. Electroacupuncture was conducted for30 minime, once a day, and 6 times/week. One day was free from treatment between 2 weeks. Treatment for 4 weeks was 1 course of treatment, and the effect was observed after 1 course.Results： Cured： 39 cases, markedly effective： 13 cases, effective： 6 cases, ineffective： 3 cases. The cure rate was 65%, and the total effective rate was up to 95.0%.Conclusion： The curative effect of electroacupuncture at facial acupoints combined with electrical stimulation on the auricular vagus nerve points for treatment of chloasma was satisfactory. 展开更多
关键词 Electroacupuncture Facial acupoints Chloasma Auricular vagus nerve points
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Warm needling on the four knee acupoints combined with Chinese herb in the treatment of knee pain after stroke 认领 引用 被引量：3
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作者 刘永锋 马晓明 +3 位作者 闫兵 缑燕华 张少芸 饶晓丹 《World Journal of Acupuncture-Moxibustion》 CAS CSCD 2015年第3期21-25,共5页
Objective To observe the clinical efficacy of warm needling on the four knee acupoints in the treatment of knee pain after stroke on the basis of Chinese herb. Methods Sixty patients with knee pain after stroke were d... Objective To observe the clinical efficacy of warm needling on the four knee acupoints in the treatment of knee pain after stroke on the basis of Chinese herb. Methods Sixty patients with knee pain after stroke were divided into a group A and a group B by random allocation, with 30 patients in each group. Patients in the group B only received the treatment by Chinese herb, which called Dúhuó Jìshēng Tāng（独活寄生汤 Pubescent Angelica and Mistletoe Decoction, add or remove ingredients depending on conditions）; patients in the group A additionally received warm needling on the basis of Chinese herb. Four knee acupoints were selected as master acupoints and Hèd ng（鹤顶 EXLE 2）, Yánglíngquán（阳陵泉 GB 34） and Zúsānl（足三里 ST 36） as combining acupoints. Perpendicular insertion was conducted on Xuèh i（血海 SP 10） and Liángqiū（梁丘 ST 34） for approximately 1 cun, and oblique insertion on Nèixīy n（内膝眼 EX-LE 4） and Dúbí（犊鼻 ST 35） for approximately 1 cun at 45° in inner and upper direction to push needle tip into joint cavity. After deqi, moxibustion stick was cut to 1.5 cm long, ignited, and inserted into the needle handles in the four knee acupoints. 1–2 strips were applied. After the moxa cones were burned up, needles were retained for 10 min. 7 d was a course of treatment and observation lasted for consecutive four courses. Visual analogue scale（VAS） and Barthel Index（BI） were adopted as observational indices. Clinical efficacy was classified as clinical cured, markedly effective, effective and ineffective according to the standards described in Guidelines of Clinical Research on Chinese New Herbal Medicine. Results After treatment, total effective rate was 93.3% in the group A, including full recovery in 8 cases, markedly effective in 15 cases, effective in 5 cases, and ineffective in 2 cases; while the total effective rate was 73.3% in the group B. The difference between the two groups was statistically significant（P0.05）. In the group A, VAS scores were 6.53 ± 1.39 before treatment and 1.53 ± 0.80 after treatment and BI scores were 58.38±8.67 before treatment and 67.55 ± 12.99 after treatment; in the group B, VAS scores were 6.63 ± 1.81 before treatment and 3.33 ± 0.96 after treatment and BI scores were 57.89 ± 9.65 before treatment and 64.87 ± 12.18 after treatment. Both VAS and BI scores were improved significantly in the two groups after treatment and the improvements were statistically significant（all P0.05）. Furthermore, both VAS and BI scores of group A were superior to that of group B（P0.05）. Conclusion Additional treatment of warm needling on the four knee acupoints on the basis of Chinese herb can enhance the clinical efficacy in treatment of knee pain after stroke, contribute to the rapid recovery of knee function and improve the life quality of stroke patients. 展开更多
关键词 Warm needling the four knee acupoints knee pain after stroke
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Neuroanatomical interconnection of the complementary acupoints in the rat hindlimb 认领 引用 被引量：1
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作者 Hui WANG Jia WANG +4 位作者 Jing-jing CUI Dong-sheng XU Chen SHE Shuang WU Wan-zhu BAI 《World Journal of Acupuncture-Moxibustion》 CAS CSCD 2019年第3期206-209,共4页
Objective:The innervations in Yinlingquan(阴陵泉SP9)and Yanglingquan(阳陵泉GB34)were investigated to explore the neuroanatomical interconnection of the complementary acupoints in the rat hindlimb.Methods:A dual neural... Objective:The innervations in Yinlingquan(阴陵泉SP9)and Yanglingquan(阳陵泉GB34)were investigated to explore the neuroanatomical interconnection of the complementary acupoints in the rat hindlimb.Methods:A dual neural tracing technique was used,six male Sprague-Dawley rats were included in experiment.Under anesthesia with isoflurane,cholera toxin subunit B conjugated with Alexa Fluor 488 and 594(CTB-AF488/594)were separately injected into SP9 and GB34 in the same rat.Three days later,the neural labeling was examined in the dorsal root ganglion(DRG),spinal cord,and sympathetic chain at lumbar(L)spinal segments under a laser scanning confocal microscope.Results:All neural labeling were present on the ipsilateral side of tracer injection,including sensory,motor and sympathetic postganglionic neurons.The sensory neurons associated with SP9 and GB34 were distributed in the DRG from L2 to L6 and concentrated in L3-L4 and L4-L5 respectively,while most of the double labeled sensory neurons were presented in L4.On the other hand,the labeled motor neurons for SP9 and GB34 were observed in the dorsolateral part of spinal ventral horn at L2-L4 and L3-L5 respectively,and some of them were double labeled at L4.In addition,the sympathetic postganglionic neurons related to SP9 and GB34 were found in the lumbar sympathetic chain respectively.Conclusion:The similarities of the sensory,motor,and sympathetic innervation of SP9 and GB34 in the rat provide the neuroanatomical evidence to understand the synergetic effect that arise from the stimulation at the complementary acupoints. 展开更多
关键词 Complementary acupoints Yinlingquan(阴陵泉SP9) Yanglingquan(阳陵泉GB34) Neural tracing technique Motor neurons Sensory neurons
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Influence of cluster needling at scalp acupoints combined with rehabilitation training on balance functions of children with cerebral palsy 认领 引用 被引量：4
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作者 ZHANG Pei-yi HU Fei-fei 《World Journal of Acupuncture-Moxibustion》 CAS 2012年第4期23-26,31,共4页
Objective To observe therapeutic effects of scalp acupuncture at close acupoints combined with rehabilitation training on balance functions of children with cerebral palsy(CP).Methods Sixty children with CP were rando... Objective To observe therapeutic effects of scalp acupuncture at close acupoints combined with rehabilitation training on balance functions of children with cerebral palsy(CP).Methods Sixty children with CP were randomly divided into a scalp acupuncture combined with rehabilitation training group(group SA+RT)and a rehabilitation training group(group RT)with 30 cases in each group.Conventional rehabilitation therapy and balance training were applied in group RT,and scalp acupuncture at close acupoints in the parietal region and sub-occipital region was added besides rehabilitation training in group SA+RT.Balance functions were evaluated by using Berg rating scale,and abilities of daily living were estimated by using rating scale for activities of daily living(ADL).Results After treatment,both Berg scores for balance and ADL scores were significantly improved in both groups(all P0.05),and the improvement in group SA+RT was more obvious than that in group RT(both P0.05).Conclusion Combination of scalp acupuncture at close acupoints with rehabilitation training is superior to simple rehabilitation training in improving balance functions and activities of daily living in children with cerebral palsy. 展开更多
关键词 cerebral palsy scalp acupuncture at close acupoints rehabilitation training balance function
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IMPACTS ON THE EXPRESSION OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN ISCHEMIC BRAIN TISSUE TREATED WITH CLUSTER PUNC-TURE ON SCALP ACUPOINTS IN RATS 认领 引用 被引量：6
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作者 李宝栋 王志勇 +5 位作者 白晶 白海娟 公维志 闫瑞萍 刘振江 王利春 《World Journal of Acupuncture-Moxibustion》 CAS 2008年第1期38-44,共7页
Objective To probe into the impacts on the expression of vascular endothelial growth factor （VEGF） in ischemic brain tissue treated with cluster puncture on scalp acupoints in rats, Methods 128 rats were randomized ... Objective To probe into the impacts on the expression of vascular endothelial growth factor （VEGF） in ischemic brain tissue treated with cluster puncture on scalp acupoints in rats, Methods 128 rats were randomized into pseudo-operation group, model group, scalp-needling group and cluster-needling group, In scalp-needling group, penetration method was used on the focal side from Bǎihuì （百会 GV20） to Qǔbīn （曲鬓 GB7）, and in cluster-needling group, penetration method was used on both sides from GV20 to GB7, and a common needling on GV 20. Needles were punctured 2 mm in depth, constantly rotated for 10min, retained for 2 h. Immunohistrochemical method was applied to determine VEGF expression and microvessel density （MVD）. Results With the intervention of cluster puncture on scalp acupoints, VEGF： expressions on every time-spot after ischemia were enhanced apparently, superior to those in scalp-needling group. On the three time-spots of the 7^th, 14^th and 21^st days, MVD was increased after cluster puncture on scale acupoints, superior to those in scalp-needling group. Conclusion Cluster puncture on scalp acupoints up-regulated VEGF expression and promoted regeneration of microvessel. 展开更多
关键词 Cluster puncture on scalp acupoints Rat Ischemia Vascular endothelial growth factor （VEGF）
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Enhanced expression of epidermal growth factor receptor gene in gastric mucosal cells by the serum derived from rats treated with electroacupuncture at stomach meridian acupoints 认领 引用 被引量：12
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作者 Zong-Bao Yang Jie Yan Xiao-Ping Zou Shou-Xiang Yi Xiao-Rong Chang Ya-Ping Lin Xi-Ping Li 《World Journal of Gastroenterology》 SCIE CAS 2006年第34期5557-5561,共5页
AIM: To investigate the effect of serum derived from rats treated with electroacupuncture at stomach meridian acupoints on the expression of epidermal growth factor receptor (EGFR) gene in gastric mucosal cells. METHO... AIM: To investigate the effect of serum derived from rats treated with electroacupuncture at stomach meridian acupoints on the expression of epidermal growth factor receptor (EGFR) gene in gastric mucosal cells. METHODS: The stress-induced gastric mucosal injury in rat model was established by water-immersion and restrained stress methods. 52 rats were randomly divided into: normal group (n = 8), model group (n = 8), model serum group (n = 12), stomach serum group (n = 12), and gallbladder serum group (n = 12). The gastric mucosal cells were separated by pronase-EDTA digestion method and incubated with serum. The EGFR gene expression in gastric mucosal cells was detected by reverse transcription-polymerase chain reaction (RT-PCR) method. RESULTS: Compared with normal group (0.6860 ± 0.0594), the serum derived from rats of the stomach group (1.2272 ± 0.0813, P = 0.00 0.05) and in model serum group (0.8516 ± 0.0409) with an extremely obvious difference (P = 0.001 < 0.01). Furthermore, the EGFR gene expression in stomach serum group was significantly higher than that in gallbladder serum group (P = 0.00 < 0.01). CONCLUSION: The present study shows that serumderived from rats treated with electroacupuncture at stomach meridian acupoints can distinctly increase the EGFR gene expression of gastric mucosal cells. Therefore, there is certain meridian specificity in the serum, which could provide a proof for the TCM theory “particular relation between meridian and internal organ”. 展开更多
关键词 Electroacupuncture Serum Stomach meridian acupoints Gastric mucosal cells Epidermal growth Factor receptor Gene expression
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Therapeutic effects on spastic cerebral palsy in children Acupuncture and massage at the Shu and He acupoints versus routine acupoints 认领 引用 被引量：8
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作者 Xue-feng Wang Xiao-li Hu 《Neural Regeneration Research》 SCIE CAS 2008年第1期53-56,共4页
BACKGROUND： Based on clinical findings and syndromes, it has been previously shown that therapeutic methods for cerebral palsy can be greatly improved by selecting fewer, but more accurate acupoints. Therefore, great... BACKGROUND： Based on clinical findings and syndromes, it has been previously shown that therapeutic methods for cerebral palsy can be greatly improved by selecting fewer, but more accurate acupoints. Therefore, greater therapeutic efficacy for cerebral palsy could be obtained by selecting the five Shu acupoints, which are located at the qi-intersecting point of the twelve meridians below the elbow and knee. OBJECTIVE： To treat children with spastic cerebral palsy using acupuncture and massage at the Shu and He points through a combination of rehabilitative training, and to compare the effects with routine acupuncture and massage. DESIGN： A randomized controlled clinical trial. SETTING： Rehabilitation Center for Cerebral Palsy, Department of Pediatrics, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine. PARTICIPANTS： Sixty children with spastic cerebral palsy were selected from the Rehabilitation Center for Cerebral Palsy, Department of Pediatrics, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from May 2003 to February 2006. There were 38 boys and 22 girls, aged 10 months to 4 years old, muscle strength ranging from grade I to grade IV. The children were randomly divided into a treatment group （n =30） and a control group （n =30）. Informed consent for the therapeutic program was obtained from the relatives of all enrolled children. The study was approved by the Hospital＇s Ethical Committee. METHODS： All children were given exercise and occupational therapy based on standard treatments. （1） In the control group, the children were additionally treated with routine acupuncture and massage during the one-month basic rehabilitative training. The acupuncture needles were manipulated alternately at the acupoints of Jianyu, Shousanli, Binao, Hegu, Huantiao, Xuanzhong, and Biguan. They were treated once per day, 6 days a week, followed by one day of rest. The children＇s limbs were first massaged by pressing, stretching, rolling, and kneading. Then, the same acupuncture points were pressed with the thumb for 30 minutes each time, once a day, 6 days a week, followed by one day of rest. The treatment continued for 1 month. （2） In the treatment group, the children were administered acupuncture and massage at the Shu and He points during the one-month basic rehabilitative treatment. For acupuncture of the upper limbs, the following acupoints were used： Sanjian and Quchi of the Large Intestine Meridian of Hand-Yangming, and Houxi and Xiaohai of the Small Intestine Meridian of Hand-Taiyang. The acupoints were acupunctured alternately every other day. For acupuncture of the lower limbs, the following acupoints were used; Zulinqi and Yanglingquan of the Gall bladder Meridian of Foot-Shaoyang, Taibai and Yinlingquan of the Spleen Meridian of Foot-Taiyang, or Xiangu and Zusanli of the Stomach Meridian of Foot-Yangming. The acupoints were acupunctured alternately every other day. Three needles were for the medial malleolus and three needles for the lateral malleolus. They were treated once a day, 6 days a week, followed by one day of rest. The children＇s limbs were first massaged by means of pressing, stretching, rolling, and kneading. The same acupuncture points were then pressed with the thumb for 0.5-1 minute at each point, 30 minutes each time, once a day, 6 days a week, followed by one day of rest. MAIN OUTCOME MEASURES： Therapeutic efficacy was evaluated using gross motor function measurements, as well as activity of daily living scale before and after treatment. RESULTS： All 60 enrolled children with spastic cerebral palsy were included in the final analysis of results. （1） Comparison of gross motor function scores： The gross motor function score after treatment was significantly higher in both the treatment group and control group than before treatment （t = -3.86 and -8.882, respectively, P 〈 0.05）. The scores in the treatment group were significantly higher than the control group scores （t = -7.166, P 〈 0.01）. （2） Changes in activity of daily living scores： The scores for activity of daily living in the treatment group was significantly higher after treatment than before treatment （t = -3.933, P 〈 0.01）, and was also significantly higher than the control group （t = -0.671, P 〈 0.05）. CONCLUSION： Acupuncture and massage at the Shu and He acupoints can significantly ameliorate motor function deficits and movement disabilities in children with spastic cerebral palsy. The therapeutic efficacy at these acupoints is better than routine acupuncture and massage. 展开更多
关键词 cerebral palsy Shu and He acupoints acupuncture massage
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Tuina on acupoints for 80 cases of infantile hypermyotonia 认领 引用 被引量：2
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作者 崔丽娜 李种泰 《World Journal of Acupuncture-Moxibustion》 CAS CSCD 2017年第4期57-59,共3页
Objective To observe the clinical efficacy of tuina on the acupoints for infantile hypermyotonia. Methods Tuina on the acupoints was given to 80 cases of infantile hypermyotonia. Acupoint selection： Jianyu （肩髃LI 1... Objective To observe the clinical efficacy of tuina on the acupoints for infantile hypermyotonia. Methods Tuina on the acupoints was given to 80 cases of infantile hypermyotonia. Acupoint selection： Jianyu （肩髃LI 15）, Quchi （曲池 LI 11）, Waiguan （外关 TE 5） and Hegu （合谷LI 4） were adoted on the upper limbs, and Fengshi （风市GB 31）, Zusanli （足三里 ST 36）, Xuanzhong （悬钟GB 39）, Taixi （太溪 El 3）, T^ichang （太冲 LR 3）, Jiexi （解溪 ST 41） and Weizhong （委中 BL 40） were adopted on the lower limbs. The acupoints were pressed and rubbed rhythmically with the fingerprint surface of thumb of the doctor for 15-20 min. Then the foot-taiyang bladder meridian was rubbed and pushed, and the therapy of pinching along the spine was applied. The treatment was conducted for once a day, and treatment for 20 days was considered as one course. The muscular tension of the infantile patients was examined after each course of treatment, when the muscular tension returned to level O, the treatment can be ceased, otherwise, the treatment should be continued. Results After one course of treatment, the muscular tension of 12 infantile patients returned to level 0, accounting for 15.0% （12/80）, after two courses of treatment, the muscular tension of 56 infantile patients returned to level 0, accounting for 70.0% （56/80）, after three courses of treatment, the muscular tension of 10 infantile patients returned to level O, accounting for 12.5% （10/80）, the muscular tension of 2 infantile patients returned to level 0 after more than three courses of treatment, accounting for 2.5% （2/80）. Conclusion Tuina on the acupoints is an effective therapy for infantile hypermyotonia. 展开更多
关键词 Tuina on the acupoints infantile hypermyotonia
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