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Effect of Controlled Atmosphere Storage(CAS)Technology of Flue-cured Tobacco Laminas on the Alcoholization Quality of Tobacco 认领 引用 被引量：1
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作者 杨欣玲 《Agricultural Science & Technology》 CAS 2017年第12期2547-2553,共7页
To achieve the continuous maintainence of optimum quality state of flue- cured tobacco laminas and the effective regulation and control on alcoholization time for controlled atmosphere storage （CAS） method in the pr... To achieve the continuous maintainence of optimum quality state of flue- cured tobacco laminas and the effective regulation and control on alcoholization time for controlled atmosphere storage （CAS） method in the process of storage, the lam- ina samples of natural alcoholization for 1 year were selected. Comparable analysis on the appearance quality, chemical components and sensory quality of flue-cured tobacco laminas in the process of alcoholization was carried out by using the meth- ods of CAS and natural alcoholization. The results showed that appearance and color through the treatment of natural alcoholization were deep, browning and ac- companied by the phenomenon of oil, while color scale of flue-cured tobacco lami- nas through the treatment of CAS was uniform, fullness was better, and these two methods were close or identical after opening for 3 months. The contents of total sugar and reducing sugar during the process of alcoholization were also gradually decreased, but the ratio of reducing sugar to total sugar of laminas via CAS was higher than that of the natural alcoholization treatment. Compared with the natural alcoholization,the descending trends of total nitrogen and nicotine contents during CAS were gentler, the ratio via CAS was closer to 1, and the coordination of chemical components was more superior. During the period of alcoholization for 6 to 12 months, sensory quality of laminas via the natural alcoholization treatment was more superior than that of CAS treatment. However, after 18 months of alcoholiza- tion, sensory quality of laminas via the CAS treatment was more superior than that of the natural alcoholization treatment, and the CAS treatment could improve opti- mum sensory quality by 0.5 to 1.5 scores. Additionally, the CAS treatment could prolong the time of optimum alcoholization quality for 6 months, compared with the treatment of natural alcoholization. The CAS method could influence the alcohoJiza- tion quality of flue-cured tobacco laminas and prolong the retention period of opti- mum quality status for flue-cured tobacco laminas by regulating the environmental aas composition, thereby realizin.q quality control of flue-cured tobacco laminas. 展开更多
关键词 Flue-cured tobacco laminas Controlled atmosphere storage （CAS） To-bacco alcoholization Chemical components Sensory quality Alcoholization peak
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Photo-induced stereoselective 2-deoxyglycoside synthesis from glycals with carboxylic acids and alcohols 认领 引用 被引量：1
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作者 Xianrong Zeng Hui-Ying Shi +1 位作者 Huiqian Huang Zhaobin Wang 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第5期313-319,共7页
Synthesizing 2-deoxyglycosides,prevalent motifs in bioactive molecules,presents significant challenges in stereocontrol and functional group tolerance.We report a metal-free,photo-induced O-glycosylation of glycals us... Synthesizing 2-deoxyglycosides,prevalent motifs in bioactive molecules,presents significant challenges in stereocontrol and functional group tolerance.We report a metal-free,photo-induced O-glycosylation of glycals using acridinium salts under visible light.This method effectively couples diverse glycals with both carboxylic acids and alcohols,providing facile access to α-2-deoxyglycosides under mild conditions with broad substrate scope and functional group compatibility.The protocol exhibits highα-stereoselectivity with carboxylic acids and moderateα-selectivity with alcohols,enabling late-stage functionalization of complex molecules,including amino acids,peptides,and drugs.Mechanistic experiments implicate the possible involvement of radical intermediates,potentially operating via a chain reaction.Notably,2-deoxyglycosylation of NSAIDs using this method enhanced their neuroprotective properties in vitro.This photo-induced strategy offers a practical and versatile platform for accessing complex 2-deoxyglycans relevant to medicinal chemistry and chemical biology. 展开更多
关键词 2-Deoxyglycoside O-Glycosylation Carboxylic acids Alcohols Glycals
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Highly Tough,Anti-freezing,Sensitive Polyvinyl Alcoholbased Organic Hydrogel for Wearable Flexible Strain Sensor 认领 引用
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作者 LIU Peng SHI Qiangfei +7 位作者 SUN Qilin LIU Feicong YANG Yuli SHANG Zhongdan DU Xiangrong CHEN Changxiu LI Yuanhang ZHANG Hanzhi 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS CSCD 2026年第4期1123-1133,共11页
A novel PVA/EG/GE/LiCl(PEGL)multifunctional hydrogel was developed by using a binary of ethylene glycol(EG)/water as solvent,with gelatin(GE)and PVA as the skeletons and lithium chloride(LiCl)for conductivity.The expe... A novel PVA/EG/GE/LiCl(PEGL)multifunctional hydrogel was developed by using a binary of ethylene glycol(EG)/water as solvent,with gelatin(GE)and PVA as the skeletons and lithium chloride(LiCl)for conductivity.The experimental results indicate that,compared to four other hydrogels,the PEGL hydrogel exhibits the best tensile strength(3.92±0.12 MPa),a good elongation at break(375.22±11.25%),and excellent anti-freezing properties,being able to withstand approximately 6500 times its own weight without breaking.Moreover,the PEGL organic hydrogel sensor has high sensitivity and rapid response characteristics,capable of transforming body movements into repeatable and stable electrical signals.This study provides new ideas for the development of new types of high-performance wearable flexible strain sensors. 展开更多
关键词 strain sensor hydrogel polyvinyl alcohol anti-freezing
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Ab initio Chemical Kinetics of(2-Furyl)(hydroxy)methyl with O2 认领 引用
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作者 Lili Xing Jintao Cui +5 位作者 Qianhao Chen Liuchao Lian Huanhuan Wang Yunrui He Mengjie Liu Xuetao Wang 《Chinese Journal of Chemical Physics》 SCIE EI CAS CSCD 2026年第2期274-284,I0113-I0141,I0171,共11页
In this work,based on the ab initio method,the reaction mechanism of the low-temperature oxidation of 2-furfuryl alcohol(2FFOH)is stud-ied.(2-furyl)(hydroxy)methyl(furylCHOH,labeled as R)and O2were taken as the bim... In this work,based on the ab initio method,the reaction mechanism of the low-temperature oxidation of 2-furfuryl alcohol(2FFOH)is stud-ied.(2-furyl)(hydroxy)methyl(furylCHOH,labeled as R)and O2were taken as the bimolecular reac-tants,and the energy diagram was determined by a high-level quan-tum chemical method(CCSD(T)/CBS//M05-2X/jun-cc-pVTZ).The equilibrium geometry and vibrational frequencies of the reactants,intermediates,transition states,and products were determined by the M05-2X/jun-cc-pVTZ method.Then,the Rice-Ramsperger-Kassel-Marcus/Master equation method was used to calculate the temperature-and pressure-dependent rate coefficients.O2addition to furylCHOH needs to overcome energy barriers of 2.35-7.26 kcal/mol to generate three kinds of peroxide radicals,2-[(2-furyl)(hydroxy)methyl]dioxidanyl(RO2α),2-{2-[(Z)-hydrox-ymethylidene]-2,3-dihydro-3-furyl}dioxidanyl(RO2γ)and 2-{5-[(Z)-hydroxymethylidene]-2,5-dihydro-2-furyl}dioxidanyl(RO2ε).The calculation results show that peroxide RO2εis the main product when the reaction temperature does not exceed 800 K at 1 atm.Moreover,fur-fural(P21)and HO2become dominant when temperature is above 800 K at 1 atm,which are formed via concerted HO2elimination mechanism of three peroxides.The slow reaction rate of RO2α→INT1 via an intramolecular 1,5 H-shift indicates the trend of low oxidation reactivi-ty of 2FFOH. 展开更多
关键词 2-Furfuryl alcohol Oxidation Quantum chemical calculations Thermodynam-ics Reaction kinetics
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Elucidating the protective mechanisms of Chenpi against alcoholic liver injury through integrated analysis of biochemical markers,microbiome,and transcriptome 认领 引用
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作者 Yanfang Liao Zhaoping Pan +5 位作者 Fuhua Fu Mingfang Peng Yanjiao Fu Wenbin Xiao Yang Shan Jiajing Guo 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第4期1920-1933,共14页
Alcoholic liver injury(ALI)has emerged as a significant public health concern,necessitating the urgent identification of medicinal-food resources for its prevention and treatment.As a natural medicinal food resource,C... Alcoholic liver injury(ALI)has emerged as a significant public health concern,necessitating the urgent identification of medicinal-food resources for its prevention and treatment.As a natural medicinal food resource,Chenpi(CHE)is rich in various flavonoid bioactive compounds and exhibits potential antioxidant,anti-inflammatory,and hepatoprotective effects.However,the effect and mechanism of CHE in preventing and improving ALI are not yet known.This study sought to elucidate CHE's hepatoprotective mechanisms in ALI from the biochemical markers,microbiome and transcriptome perspectives.Results showed that CHE ameliorated ALI by improving oxidative stress,inflammatory cytokines and liver function.16S r RNA analysis revealed that CHE alleviated ALI pathological progression primarily by restoring gut microbiota composition.Transcriptomic analysis showed that CHE improved ALI mainly related to MAPK signaling pathway.Pearson correlation analysis revealed that Candidatus_Saccharimonas,Turicibacter,and Clostridium_sensu_stricto_1 play key roles in the process by which CHE ameliorates alcohol-induced inflammation and pathological angiogenesis.These findings revealed that CHE has the potential to be used as a functional food to prevent or improve ALI. 展开更多
关键词 Chenpi Alcoholic liver injury Microbiome Transcriptome
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Efficient Oxidation of Alcohols Using a Bioinspired Tetradentate Aminopyridine Manganese Catalyst with H2O2:Batch and Continuous Flow Studies 认领 引用
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作者 Xia Chunnian Chen Kailin +5 位作者 Jin Nuoqi Nan Xinhui Wang Bingyang Wu Xinyi Sun Qiangsheng Sun Wei 《有机化学》 SCIE CAS CSCD 北大核心 2026年第3期986-992,共7页
Bioinspired manganese complexes with tetradentate aminopyridine ligands(Mn-N4)have shown excellent promise as effective catalysts for various selective oxidation reactions.The synthesis of a series of Mn-N4 and their ... Bioinspired manganese complexes with tetradentate aminopyridine ligands(Mn-N4)have shown excellent promise as effective catalysts for various selective oxidation reactions.The synthesis of a series of Mn-N4 and their application in the catalytic oxidation of secondary alcohols are reported.This method utilizes hydrogen peroxide as an environmentally benign oxidant with a small amount of acetic acid as an additive.Notably,the continuous-flow process using this catalyst system achieves rapid conversion,reducing the reaction time from 90 min in a traditional batch system to 1.6 min residence time in the continuous-flow process.This approach offers a promising and practical strategy for the industrial oxidation of secondary alcohols,demonstrating significant potential for broader applications. 展开更多
关键词 bioinspired catalysis oxidation of alcohol manganese complex continuous flow
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Shared genetic variants across substance use disorders implicate common neurobiological pathways,a genome-wide mixed methods study 认领 引用
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作者 Børge Holen Zillur Rahman +11 位作者 Alexey A.Shadrin Romain Icick Kevin S.O'Connell Linn Rødevand Nadine Parker Markos Tesfaye Piotr Jaholkowski Oleksandr Frei Anders M.Dale Srdjan Djurovic Ole A.Andreassen Olav B.Smeland 《General Psychiatry》 CAS CSCD 2026年第2期103-114,共12页
Background Substance use disorders(SUDs)are highly heritable,but the extent of shared and distinct genetic architecture across different SUDs is unclear.Aims To compare the genetic architectures of alcohol use disorde... Background Substance use disorders(SUDs)are highly heritable,but the extent of shared and distinct genetic architecture across different SUDs is unclear.Aims To compare the genetic architectures of alcohol use disorder(AUD),cannabis use disorder(CUD)and opioid use disorder(OUD)and to identify shared and unique genetic loci.Methods We analysed large-scale genome-wide association study(GWAS)summary statistics from individuals of European ancestry recruited in Europe and the USA.The mixture model MiXeR was used to estimate the unique genetic architecture characteristics of each SUD,including its polygenicity,single nucleotide polymorphism(SNP)-heritability and discoverability,a measure of the distribution of genetic signal across all causal variants.Pairwise conditional/conjunctional false discovery rate(cond/conjFDR)analyses identified shared loci,followed by biological annotation of implicated genes.Results AUD demonstrated the highest polygenicity,followed by CUD and OUD.SNP-based heritability was0.10 for AUD and OUD and 0.01 for CUD.Discoverability was highest for OUD,followed by AUD and CUD.Currently,genome-wide significant SNPs explain 2.0%of AUD,0.3%of CUD and 0.2%of OUD variance.Cond/conjFDR identified 39 novel loci for AUD,10 for CUD and 1 for OUD.Of implicated genes,most were expressed in the brain,including several involved in gamma-aminobutyric acid and dopaminergic neurotransmission,opioid neurophysiology,myelination,DNA recombination,apoptosis and ubiquitin-dependent protein catabolism.Conclusions SUDs have polygenic architectures with many shared loci and are similar with regards to some characteristics.However,the level of polygenicity differs across SUDs,with AUD being considerably more polygenic than OUD,whereas CUD is intermediate in terms of its polygenicity.The novel loci implicate genes primarily expressed in the brain,involving a variety of biological functions.The findings expand our view of the aetiology of these disorders,while supporting the hypothesis of a shared set of pleiotropic SUD genes. 展开更多
关键词 mixture model mixer cannabis use disorder identify shared unique genetic locimethods compare genetic architectures alcohol use disorder aud cannabis use disorder cud substance use disorders opioid use disorder oud alcohol use disorder
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Chronic alcohol consumption compromises gut barrier integrity and promotes endotoxemia:Implications for sepsis susceptibility in immunocompromised hosts 认领 引用
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作者 Thansita Bhunyakarnjanarat Chatsuree Suksamai +3 位作者 Dhammika Leshan Wannigama Kent Doi Wiwat Chancharoenthana Asada Leelahavanichkul 《Animal Models and Experimental Medicine》 CAS CSCD 2026年第5期967-979,共13页
Background:Gut barrier integrity prevents microbial translocation and systemic infection.Chronic alcohol disrupts this barrier,but its role in infection susceptibility among immune-compromised hosts remains unclear.We... Background:Gut barrier integrity prevents microbial translocation and systemic infection.Chronic alcohol disrupts this barrier,but its role in infection susceptibility among immune-compromised hosts remains unclear.We investigated how chronic alcohol promotes gut barrier dysfunction,endotoxemia,and dysbiosis,predisposing to bacterial translocation and sepsis.Methods:Twenty-four-week-old female FcγRIIb−/−and wild-type mice received oral gavage of 35%ethanol(4.2 g/kg/day)or water for 10 weeks.Gut barrier integrity was assessed by serum endotoxin,FITC-dextran permeability,ileal claudin-1,and in-testinal IgGeutrophil infiltration.Systemic inflammation was evaluated by serum TNF-α,IL-1β,and IL-6;gut microbiota by 16S rRNA sequencing.Bone marrow-derived macrophages and hepatocytes from both genotypes were stimulated with LPS or ethanol to assess inflammatory responses,mitochondrial damage,and cGAS-STING activation.Results:Chronic alcohol induced gut barrier dysfunction in both groups,with more severe effects in FcγRIIb−/−mice,which showed marked increases in serum endotoxin and FITC-dextran permeability,reduced claudin-1,and enhanced intestinal IgG depo-sition with neutrophil accumulation.Serum TNF-α,IL-1β,and IL-6 were significantly elevated,reflecting a sepsis-like profile.Alcohol induced dysbiosis with an increased Firmicutes-to-Bacteroidota ratio,elevated Lachnospiraceae,and reduced Alistipes,Bacteroides,and Odoribacter.In vitro,LPS elicited stronger inflammation than ethanol in both cell types,with FcγRIIb−/−cells producing greater cytokine levels.Both stimuli caused comparable mitochondrial damage and cGAS-STING activation.Conclusions:Alcohol-induced gut barrier dysfunction,endotoxemia,and dysbiosis predispose to bacterial translocation and early sepsis,particularly in hosts with impaired inhibitory Fcγreceptor signaling,supporting gut barrier preservation as a strategy for preventing alcohol-associated infections and sepsis. 展开更多
关键词 alcohol endotoxemia gut barrier dysfunction gut microbiota sepsis susceptibility
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Role of miRNAs from mesenchymal stem cell-derived extracellular vesicles in neuroinflammation and behavioral impairments induced by chronic alcohol consumption in female mice 认领 引用
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作者 Susana Mellado Najoua Touahri +6 位作者 Sandra Montagud-Romero Carla Perpiñá-Clérigues Francisco García-García Victoria Moreno-Manzano Consuelo Guerri Marta Rodríguez-Arias María Pascual 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第6期2370-2379,共10页
Mesenchymal stem cell-derived extracellular vesicles have emerged as a promising form of regenerative and immunomodulatory therapy;indeed,micro(mi)RNAs contained within mesenchymal stem cell-derived extracellular vesi... Mesenchymal stem cell-derived extracellular vesicles have emerged as a promising form of regenerative and immunomodulatory therapy;indeed,micro(mi)RNAs contained within mesenchymal stem cell-derived extracellular vesicles modulate target gene expression and impact disease-associated pathways.Chronic alcohol consumption leads to neuroinflammation,brain damage,and impaired cognition.Evidence indicates that females are more vulnerable to alcohol-induced damage than males.While mesenchymal stem cell-derived extracellular vesicles have been studied in various neuroinflammatory conditions,their potential to counteract alcohol-induced brain damage remains unclear.In this study,we investigated whether repeated intravenous administration of mesenchymal stem cell-derived extracellular vesicles could ameliorate neuroinflammation and behavioral impairment induced by chronic alcohol consumption in female mice.Mesenchymal stem cell-derived extracellular vesicles diminished the increased binding of a micro-positron emission tomography tracer(18F-FDG)when analyzing whole-brain 3D images and brain coronal sections of ethanol-treated mice.Mesenchymal stem cell-derived extracellular vesicle administration protected against ethanol-induced proinflammatory gene upregulation,cognitive dysfunction,and the conditioned rewarding effects of cocaine.MiRNA sequencing data from mesenchymal stem cell-derived extracellular vesicles revealed the elevated expression of extracellular vesicle-derived miR-483-5p and miR-140-3p in the brains of ethanol-treated female mice following mesenchymal stem cell-derived extracellular vesicle administration.In addition,mesenchymal stem cell-derived extracellular vesicles modulated the expression of pro-inflammatory-related miRNA target genes(e.g.,Socs3,Tnf,Mtor,and Atf6)in the brains of ethanol-treated female mice.These results suggest that mesenchymal stem cell-derived extracellular vesicles could function as a neuroprotective therapy to ameliorate the neuroinflammation,cognitive dysfunction,and conditioned rewarding effects of cocaine associated with chronic alcohol consumption. 展开更多
关键词 behavior chronic alcohol consumption cognitive ethanol extracellular vesicles female mesenchymal stem cells miRNAs neuroinflammation
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Laetiporus sulphureus polysaccharides ameliorate chronic alcoholic liver disease by activating p62/Nrf2,AMPK pathways and reshaping gut microbiota 认领 引用
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作者 Huajie Zhao Liang Liu +6 位作者 Ningning Liu Baoguo Deng Min Li Duan Li Le Jia Ge Wang Fan Yang 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第3期1323-1342,共20页
One novel enzymatic-extractable polysaccharide(ES1)from fruiting bodies of Laetiporus sulphureus was obtained by isolation and purification using a DEAE Seplife FF chromatographic column and a Sephacryl S-400HR column... One novel enzymatic-extractable polysaccharide(ES1)from fruiting bodies of Laetiporus sulphureus was obtained by isolation and purification using a DEAE Seplife FF chromatographic column and a Sephacryl S-400HR column.The hepatoprotective ability of ES1 against chronic alcoholic liver disease(ALD)and its underlying mechanism were explored.The results indicated that ES1 could alleviate liver damage in ALD mice by activating sequestosome-1uclear factor E2-related factor 2(P62/Nrf2)pathway to increase antioxidant enzyme activities against oxidative stress,regulating adenosine monophosphate-activated protein kinase(AMPK)pathway to promote fatty acid oxidation and inhibit cholesterol synthesis against lipid metabolism disorders,and improving gut microbiota(increasing the relative abundances of Ligilactobacillus and Akkermansia,and reducing the relative abundances of Enterococcus,Romboutsia,Allobaculum,Coriobacteriaceae_UCG-002,Dubosiella and Faecalibaculum)against intestinal barrier dysfunction.Meantime,structural analysis showed that ES1 with molecular weight of 25.79 kDa was composed ofα-DManp-(1→,→2,6)-α-D-Galp-(1→,→6)-α-D-Galp-(1→,→3)-α-L-Fucp-(1→,andα-D-Glcp-(1→,and its structure was also inferred.Therefore,these data support the application of ES1 as a potential functional food or drug for treating ALD. 展开更多
关键词 Laetiporus sulphureus polysaccharides Alcoholic liver disease Lipid metabolism Oxidative stress Gut microbiota
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Amorphous PdSe/crystalline Pt heterostructure enhances polyhydric alcohols electrooxidation 认领 引用
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作者 Jie Li Mengyun Hu +4 位作者 Tianpeng Liu Xin Wang Jun Yu Changqing Ye Yukou Du 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第2期577-581,共5页
The insufficient performance of Pt and Pd benchmark catalysts remains a significant obstacle to the practical application of direct liquid fuel cells.In this study,we report a synthesis of amorphous PdSe/crystalline P... The insufficient performance of Pt and Pd benchmark catalysts remains a significant obstacle to the practical application of direct liquid fuel cells.In this study,we report a synthesis of amorphous PdSe/crystalline Pt nanoparticles(AC-PdPtSe NPs)by chemical leaching of PdPtSe NPs.AC-PdPtSe NPs display significantly enhanced activity and stability for the electrooxidation of ethylene glycol and glycerol,far surpassing that of amorphous-dominant PdPtSe NPs,commercial Pd/C,and Pt/C catalysts.Notably,the integration of crystalline and amorphous domains leverages the advantages of high electrical conductivity and a wealth of active sites,which can substantially accelerate reaction kinetics.Furthermore,detailed investigations reveal that the boundary between the Pt crystalline and PdSe amorphous phases induces a 3%surface tensile strain.The formation of amorphous-crystalline heterointerfaces optimizes the d-band states,thereby strengthening the adsorption and activation of ethylene glycol and glycerol.This study highlights the advance in phase engineering toward the development of highly active noble-metal nanostructures. 展开更多
关键词 Phase engineering Tensile strain Amorphous-crystalline heterointerface Chemical leaching Polyhydric alcohols electrooxidation
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Clinical assessment of malnutrition among patients with alcoholic liver cirrhosis: A single-center study in Southern China 认领 引用
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作者 Xiao-Qin Wu Yi-Yan Liu +4 位作者 Hong-Sheng Yu Kodjo-Kunale Abassa Li-Li Pan Bi-Lun Ke Yun-Wei Guo 《World Journal of Gastroenterology》 SCIE CAS 2026年第26期59-74,共16页
BACKGROUND The burden of alcohol-related liver disease in China is becoming increasingly significant,and malnutrition in Chinese patients with alcoholic liver cirrhosis(ALC)is inadequately characterized.AIM To evaluat... BACKGROUND The burden of alcohol-related liver disease in China is becoming increasingly significant,and malnutrition in Chinese patients with alcoholic liver cirrhosis(ALC)is inadequately characterized.AIM To evaluate nutritional assessment tools,detail anthropometric and micronutrient alterations,and their associations with disease severity and prognosis in ALC.METHODS This case-control study included hospitalized male ALC patients,age-matched patients with hepatitis B virus-related cirrhosis(HBV-C),and relatively healthy controls(HCs).Nutritional status was assessed using subjective global assessment(SGA)and nutritional risk screening 2002(NRS-2002)scores,anthropometric measurements,and serum levels of trace elements and vitamins.Kaplan-Meier analysis and Cox regression were employed to determine survival outcomes.RESULTS We enrolled 249 male ALC patients,103 HBV-C patients,and 83 HCs.ALC patients demonstrated significantly lower hemoglobin,magnesium(Mg),vitamin D(VD),vitamin B(VB)1,and VB2 levels than the HBV-C group(P<0.001).Notably,ALC patients exhibited a unique nutritional phenotype:Increased central adiposity(higher waist circumference,hip circumference,and abdominal fat thickness)despite higher mid-arm circumference(AC)and arm muscle circumference values than HBV-C patients.Malnutrition progressed with disease severity;serum zinc(Zn),Mg,corrected calcium and VD were significantly lower in Child-Pugh B/C than in class A patients.Low albumin levels,Child-Pugh B/C,reduced AC,and high SGA/NRS-2002 scores were associated with decreased survival.Multivariate analysis identified low Zn[hazard ratio(HR)=0.51],low VD(HR=0.92),and reduced AC(HR=0.85)as independent predictors of liver-related mortality.CONCLUSION ALC patients exhibit unique malnutrition phenotypes and micronutrient deficiencies.Low Zn,VD,and AC are independent prognostic predictors,necessitating etiology-specific nutritional interventions to improve clinical outcomes. 展开更多
关键词 Alcoholic liver cirrhosis Malnutrition Micronutrients Body composition Anthropometric evaluation Nutritional assessment tools Prognosis
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Selective oxidation of aromatic alcohols to aldehydes catalyzed by HKUST-1-derived Cu-based carbon material and TEMPO 认领 引用
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作者 LUO Yang ZHANG Shujing +1 位作者 MA Hong WANG Chenguang 《燃料化学学报（中英文）》 EI CAS CSCD 北大核心 2026年第5期164-173,共10页
In this work,a Cu-based carbon catalyst(H-Cu/C)with an octahedral morphology was synthesized by pyrolyzing the metal-organic framework(MOF)precursor HKUST-1,where Cu(0)nanoparticles were uniformly dispersed in the car... In this work,a Cu-based carbon catalyst(H-Cu/C)with an octahedral morphology was synthesized by pyrolyzing the metal-organic framework(MOF)precursor HKUST-1,where Cu(0)nanoparticles were uniformly dispersed in the carbon matrix,alongside the formation of island-like Cu2O structures as the active sites.Multiple characterization techniques,including XPS,XRD,SEM and HRTEM,reveal the critical role of carbon matrix in stabilizing the metal nanoparticles.In combination with TEMPO and using molecular oxygen as a green oxidant,the H-Cu/C catalyst is highly efficient in the selective oxidation of aromatic alcohols to the corresponding aldehydes under alkali-free conditions.Using benzyl alcohol as a model substrate,an alcohol conversion of 99.2%and a benzaldehyde yield of 94.1%were achieved under mild reaction conditions(100℃,0.5 MPa O2,1 h).The catalytic system displays excellent universality for various mono-and ortho/para-disubstituted aromatic alcohols,affording an alcohol conversion of over 99%and a yield of corresponding aromatic aldehydes of above 95%.In addition,the H-Cu/C catalyst can be regenerated via H2 reduction and reused without significant loss of activity.This work provides a new strategy for designing green and efficient non-noble metal catalytic systems for the oxidation reactions. 展开更多
关键词 metal-organic frameworks(MOFs) copper-based catalysts selective oxidation aromatic alcohols TEMPO
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Stable Integration of Hydrophobic Silica Aerogels into Rubber Latex via Poly(vinyl alcohol)-assisted Aqueous Processing for Thermal Insulating Composites 认领 引用
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作者 Yan-Chun Han Fang-Shuo Li +8 位作者 Jian-Chao Zhang Quan Wang Guo-Hui Yang Miao Yu Feng Wang Yong-Xin Duan Lu Zong Bo-Xiao Li Jian-Ming Zhang 《Chinese Journal of Polymer Science》 SCIE EI CAS CSCD 2026年第3期821-832,I0016,共12页
Silica aerogels(SAs)impart low density and excellent thermal insulation to polymer systems,yet incorporating hydrophobic SAs into aqueous rubber latex systems remains challenging owing to their poor dispersibility and... Silica aerogels(SAs)impart low density and excellent thermal insulation to polymer systems,yet incorporating hydrophobic SAs into aqueous rubber latex systems remains challenging owing to their poor dispersibility and potential to destabilize the latex.Although previous studies have dispersed SAs in aqueous poly(vinyl alcohol)(PVA),the stability of such dispersions and their effectiveness as bridging media for latex integration have not been thoroughly evaluated,which limits their practical application in latex compounding.This study systematically examined how the surface chemistry governs hydrolytic stability,interfacial behavior,and latex compatibility in PVA-assisted aqueous processing.Two hydrophobic SAs were prepared:ethoxy-modified SA(E-SA)and methyl-modified SA(M-SA).Both initially formed a homogeneous PVA slurry,but E-SA rapidly hydrolyzed its surface—OCH2CH3groups,releasing ethanol,becoming hydrophilic,and undergoing irreversible nanopore collapse.In contrast,M-SA maintains its structural integrity and hydrophobicity because its—Si(CH3)3groups are highly resistant to hydrolysis.This divergence dictates the behavior during latex blending.The ethanol released from E-SA disrupts electrostatic and steric stabilization,inducing latex coagulation,whereas M-SA/PVA dispersions preserve colloidal stability across diverse latex systems.As a practical demonstration,M-SA-reinforced chlorosulfonated polyethylene(CSM)rubber latex composites show more than a 50%reduction in thermal conductivity while maintaining chemical resistance,enabling high-performance insulating protective gloves and coatings.This work establishes a critical link between aerogel surface chemistry and aqueous processing stability,providing a mechanistic foundation for the rational design of water-based rubber/silica aerogel composites and next-generation thermal insulation materials. 展开更多
关键词 Silica aerogel Poly(vinyl alcohol) Rubber latex Surface chemistry Colloidal stability
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Direct synthesis of long-chain primary alcohols from syngas over Na-driven Co2C-Co catalyst 认领 引用
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作者 Zheng Li Ziang Zhao +7 位作者 Yihui Li Yuan Lyu Li Yan Wenhao Cui Shunbin Zhu Yu Meng Hejun Zhu Yunjie Ding 《Chinese Journal of Catalysis》 SCIE EI CAS CSCD 2026年第6期371-383,共13页
The direct synthesis of high-value-added long-chain primary alcohols(LPAs,C6+OH)from syngas(CO+H2)is highly attractive.However,low selectivity of targeted products is generally obtained due to competitive dissoc... The direct synthesis of high-value-added long-chain primary alcohols(LPAs,C6+OH)from syngas(CO+H2)is highly attractive.However,low selectivity of targeted products is generally obtained due to competitive dissociative and non-dissociative CO adsorption,as well as uncontrollable chain growth that causes a complex reaction network.Herein,we report that Na-driven Co2C-Co dual active sites could be engineered by loading the Na promoter onto an activated carbon supported Co-based catalyst,achieving total alcohol selectivity of ca.46%with a remarkable LPAs fraction higher than 65%,which represents the first report of high LPA selectivity in literature.Comprehensive characterizations and experiments indicated that electron-rich state of Co2C-Co sites was generated through Na promotion,which enhances the surface basicity of the catalyst and favors chain propagation.Moreover,Na promotes the dissociation of CO to form*C species,facilitating the transformation of metallic Co into Co2C and leading to the formation of Na-driven Co2C-Co active sites that are closely associated with CO insertion.Density functional theory calculations show that Na significantly also promotes C-C coupling while inhibiting hydrogenation and promoting CO insertion,which is deemed to be the intrinsic mechanism behind the high LPAs selectivity.This work elucidates a dual role of Na in constructing active sites and modulating surface reaction energetics,providing a design paradigm to break the LPAs selectivity barrier in syngas conversion. 展开更多
关键词 Syngas conversion Alkali metal Na-driven Co2C-Co catalyst Long-chain primary alcohols Structure-performance relationship
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Modulation of the gut-liver axis by oxymatrine alleviates metabolic dysfunction-associated steatotic liver disease 认领 引用
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作者 Jing-Fang Xiong Ying He +6 位作者 Na Jiang Yi-Hui Liu Gao-Feng Chen Chang-Qing Zhao Shu-Yan Zhang Yi-Jun Wu Hong Xu 《World Journal of Gastroenterology》 SCIE CAS 2026年第16期124-145,共22页
BACKGROUND Oxymatrine(OMT)has the potential to regulate intestinal microbiota and hepatic metabolites.AIM To explore the underlying mechanisms by which OMT exerts its effects on metabolic dysfunction-associated steato... BACKGROUND Oxymatrine(OMT)has the potential to regulate intestinal microbiota and hepatic metabolites.AIM To explore the underlying mechanisms by which OMT exerts its effects on metabolic dysfunction-associated steatotic liver disease(MASLD).METHODS An MASLD rat model induced by a high-fat,high-sucrose diet was treated with OMT.Assessments included serum/Liver biochemical parameters,histopathology(hematoxylin eosin and oil red O staining),intestinal permeability,16S rRNA gut microbiota sequencing,and hepatic metabolomics.Correlation analysis linked changes in microbiota to metabolic shifts.To test the hypothesis that gut microbiota mediates the efficacy of OMT,we conducted fecal microbiota transplantation experiments.RESULTS OMT effectively alleviated MASLD in rats by improving serum lipid profiles(P<0.05),reducing hepatic steatosis(P<0.05)and inflammatory cytokine levels(P<0.05),and enhancing intestinal barrier function.It substantially restored gut microbiota diversity,increasing beneficial genera such as Lactobacillus,modulating hepatic metabolites such as luteolin(P<0.001),and lowering adrenic acid(P<0.001),which are linked to lipid and inflammatory pathways.Correlation analysis indicated a strong association between changes in specific microbiota and metabolic improvement.Fecal microbiota transplantation experiments indicated that transferring OMT-modulated microbiota recapitulated the therapeutic effects in recipients,suggesting that the gut microbiota contributed substantially to the efficacy of OMT.CONCLUSION This study indicated that OMT alleviated MASLD in rats by regulating intestinal microbiota and hepatic metabolites,highlighting its promise as a therapeutic agent. 展开更多
关键词 Metabolic dysfunction-associated steatotic liver disease Alcoholic liver disease Metabolic dysfunction-associated steatohepatitis Insulin resistance Oxidative stress
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Differential impact of high-fructose and ethanol diets on early steatohepatitis and hepatic melanocortin-4 receptor responses in rats 认领 引用
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作者 Salamah M Alwahsh Min Xu +3 位作者 Maisa Nabulsi Sabine Mihm Faisal A Alzahrani Giuliano Pasquale Ramadori 《World Journal of Hepatology》 2026年第6期234-254,共21页
BACKGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD)is increasingly driven by diets high in fructose and fat,often accompanied by alcohol consumption.The melanocortin-4 receptor(MC4R)has been imp... BACKGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD)is increasingly driven by diets high in fructose and fat,often accompanied by alcohol consumption.The melanocortin-4 receptor(MC4R)has been implicated in energy homeostasis,yet its hepatic expression in response to dietary stress remains poorly investigated.AIM To investigate the effects of obesogenic diets,high-fat diet(HFD),a high-fructose diet(70%kcal)(HFrD)and HFD supplemented with both ethanol and fructose(HF-EFr)on appetite,metabolic outcomes,serum transaminases,and hepatic MC4R expression in male SD rats over 8-week.METHODS Hepatic MC4R expression was assessed by quantitative reverse transcriptase PCR,western blotting and immunostaining.Steatosis and fibrosis were evaluated histologically.Hepatocellular DNA-synthesis was quantified by Ki-67/HepPar-1 immunostaining.RESULTS HFrD feeding resulted in hyperphagia,accelerated weight gain,endocrine alterations(leptin and Lepr signaling,impaired insulin clearance,and increased fT3/fT4 ratio),hepatomegaly,and stage 2 fibrosis.HF-EFr-fed rats consumed fewer calories but exhibited pronounced hepatocellular DNA synthesis,elevated aspartate aminotransferase levels,endothelial activation(Pecam-1),increased MC4R expression,and higher relative liver weight.Both diets induced visceral white adipose tissue expansion,hepatic steatosis,and increased expression of lipogenic(Srebp-1c,LXR-α),fructose transporter(Glut5),pro-inflammatory(Il-1β,Cxcl-1),and profibrotic(Pai-1)genes,although the timing and magnitude differed between groups.Quantitative immunofluorescence analysis revealed a diet-induced shift in MC4R subcellular localization,with nuclear-associated recruitment increasing from 69%in controls to>95%in HFrD and HF-EFr groups(P<0.001),accompanied by a significant increase in mean fluorescence intensity.CONCLUSION High-fructose and ethanol-enriched diets promote early MASLD through complementary(simultaneous)mechanisms.HFrD primarily induces metabolic overload,steatosis,and endocrine dysregulation,whereas HF-EFr enhances hepatocellular stress,inflammatory signaling,and DNA synthesis.Hepatic MC4R expression and localization respond dynamically to these dietary challenges,suggesting a potential adaptive role for peripheral MC4R signaling during early steatohepatitis. 展开更多
关键词 Metabolic dysfunction-associated steatotic liver disease Fatty liver Inflammation Fructose Alcohol
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Enhancing Corn Starch-Poly(Vinyl Alcohol)and Glycerol Composite Films with Citric Acid Cross-Linking Mechanism:A Green Approach to High-Performance Packaging Materials 认领 引用
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作者 Herlina Marta Novita Indrianti +6 位作者 Allifiyah Josi Nur Aziza Enny Sholichah Titik Budiati Achmat Sarifudin Yana Cahyana Nandi Sukri Aldila Din Pangawikan 《Journal of Renewable Materials》 EI CAS 2026年第1期127-147,共21页
Corn starch(CS)is a renewable,biodegradable polysaccharide valued for its film-forming ability,yet native CS films exhibit lowmechanical strength,highwater sensitivity,and limited thermal stability.This study improves... Corn starch(CS)is a renewable,biodegradable polysaccharide valued for its film-forming ability,yet native CS films exhibit lowmechanical strength,highwater sensitivity,and limited thermal stability.This study improves CS-based films by blending with poly(vinyl alcohol)(PVA)or glycerol(GLY)and using citric acid(CA)as a green,non-toxic cross-linker.Composite films were prepared by casting CS–PVA or CS-GLY with CA at 0%-0.20%(w/w of starch).The influence of CA on physicochemical,mechanical,optical,thermal,and water barrier properties was evaluated.CA crosslinking markedly enhanced the tensile strength,water resistance,and thermal stability of CS-PVA films while increasing transparency in CS–GLY films.At 0.20%CA,the composite achieved 34.99MPa tensile strength,reducedwater vapor permeability,andminimized water uptake.FTIR confirmed ester bond formation between CAand hydroxyl groups of CS,PVA,and GLY,whereas thermal analysis showed higher decomposition temperatures and lower weight loss in crosslinked films.Increasing CA levels also decreased opacity and improved light transmittance,indicating greater homogeneity and reduced crystallinity.This dual-polymer matrix combined with a natural crosslinking strategy provides a sustainable route to high-performance,biodegradable CS-based packaging materials. 展开更多
关键词 Corn starch poly(vinyl alcohol) glycerol citric acid cross-linking renewable packaging materials biopolymer films
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Xing-Pi-Qing-Gan decoction alleviates alcoholic liver disease by down-regulating DDIT3 and restoring Nrf2/HO-1 antioxidant signaling:Multi-omics and experimental evidence 认领 引用
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作者 Na-Fei Huang Ping Ling +3 位作者 Yu-Jie Xu Xiao-Feng Feng Yi Zheng Tao Sun 《World Journal of Gastroenterology》 SCIE CAS 2026年第8期105-125,共21页
BACKGROUND Alcoholic liver disease(ALD)is driven by oxidative stress,lipid metabolism,inflammation,and apoptosis.Current therapies lack efficacy in targeting multipathway mechanisms.Xing-Pi-Qing-Gan decoction(XPQG)is ... BACKGROUND Alcoholic liver disease(ALD)is driven by oxidative stress,lipid metabolism,inflammation,and apoptosis.Current therapies lack efficacy in targeting multipathway mechanisms.Xing-Pi-Qing-Gan decoction(XPQG)is an improved traditional Chinese medicine designed to alleviate ALD,but its molecular mechanism remains unknown.AIM To illustrate the therapeutic targets and molecular pathways of XPQG for the treatment of ALD by integrating chemical profiling,network pharmacology,transcriptomics,and experimental verification in vivo and in vitro.METHODS The components of XPQG were analyzed using ultra-high performance liquid chromatography quadrupole-time-of-flight mass spectrometry.Then,the protective effect of XPQG on ethanol-induced liver injury,especially its regulatory effect on DDIT3 expression and associated Nrf2/HO-1 antioxidant signaling,was investigated through in vivo animal experiments and in vitro cell experiments.A mouse model of ALD was developed,and the mechanism of XPQG was validated through hematoxylin and eosin(H&E)staining,Western blot,and quantitative RT-PCR.In addition,the key role of DDIT3 in XPQG-mediated protection was further verified by siDDIT3 cell transfection technology.Animal experiments with the reactive oxygen species inhibitor N-acetylcysteine(NAC)further validated the mechanism of XPQG to alleviate liver injury by regulating oxidative stress.RESULTS In ethanol-treated HepG2 cells,XPQG dose-dependently reduced the formation of lipid droplets,inhibited the expression of tumor necrosis factor-α,interleukin-6,interleukin-1β,and alleviated oxidative stress.In mice,XPQG(15.2 g/kg)lowered the liver/body weight ratio,alanine aminotransferase,aspartate aminotransferase,γ-glutamyl transferase;H&E and Oil Red O demonstrated a reduction in steatosis.Network pharmacology and RNA-seq converged on MAPK signaling,suggesting DDIT3 as a likely key effector in XPQG-mediated protection.DDIT3 knockdown in HepG2 cells attenuated the benefits of XPQG,supporting DDIT3 as a critical effector mechanism in XPQG-mediated protection.The use of NAC further illustrates the correlation of drugs to oxidative stress in disease effects.CONCLUSION In summary,the results of the study suggest that XPQG is effective in improving ethanol-induced acute liver injury(ALD).Its mechanism involves the suppression of DDIT3 and the enhancement of Nrf2/HO-1 pathway activity. 展开更多
关键词 Alcoholic liver disease Xing-Pi-Qing-Gan decoction DDIT3 Nrf2/HO-1 Oxidative stress
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Astrocytic NLRP6 inflammasome:From protective sentinels to drivers of alcohol-induced neuroinflammation 认领 引用
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作者 Seema Singh Shilpa Buch Palsamy Periyasamy 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第7期2914-2915,共2页
The innate immune system of the central nervous system(CNS),long viewed as primarily microgliadriven,is now increasingly recognized to include astrocytes as active participants in neuroimmune signaling.Chronic alcohol... The innate immune system of the central nervous system(CNS),long viewed as primarily microgliadriven,is now increasingly recognized to include astrocytes as active participants in neuroimmune signaling.Chronic alcohol exposure trigge rs oxidative stress,glial activation,and sustained inflammation,ultimately contributing to cognitive decline and neuronal injury. 展开更多
关键词 alcohol induced neuroinflammation oxidative stressglial central nervous system cns long oxidative stress astrocytes glial activation cognitive decline innate immune system
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