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Role of diffusion-weighted magnetic resonance imaging and apparent diffusion coefficient in subtyping renal cell carcinoma 认领 引用
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作者 Hira Lal Pinky Jowel +9 位作者 Pragati Verma Athar Shamim Raghunandan Prasad Anuradha Singh Uday P Singh Sanjoy K Sureka Farhana Siddiqui Manoj Jain Aneesh Srivastava Priyank Yadav 《World Journal of Radiology》 2026年第5期67-76,共10页
BACKGROUND Diffusion-weighted magnetic resonance imaging(DWI)has emerged as a noncontrast functional imaging technique for renal mass characterization.Its role in differentiating histopathological subtypes of renal ce... BACKGROUND Diffusion-weighted magnetic resonance imaging(DWI)has emerged as a noncontrast functional imaging technique for renal mass characterization.Its role in differentiating histopathological subtypes of renal cell carcinoma(RCC)remains an area of active investigation.AIM To evaluate the role of DWI and apparent diffusion coefficient(ADC)values in differentiating histopathological subtypes of RCC.METHODS In this prospective observational study,127 patients with histopathologically proven RCC who underwent preoperative magnetic resonance imaging(MRI)including DWI were analyzed.Diffusion-weighted imaging was performed using b values of 0 second/mm2 and 1000 seconds/mm2,and ADC maps were generated.ADC values were measured from solid tumor components and compared among RCC subtypes.Statistical analysis included subgroup comparisons and receiver operating characteristic curve analysis to assess the ability of ADC values to differentiate clear cell RCC(ccRCC)from non-ccRCC.RESULTS Of the 127 RCCs,97(76.4%)were ccRCC,24(18.9%)papillary RCC,and 6(4.7%)chromophobe RCC.The mean ADC value of ccRCC[(1.391±0.271)×10-3mm2/second]was significantly higher than that of papillary RCC[(0.876±0.293)×10-3mm2/second;P<0.001]and chromophobe RCC[(1.059±0.369)×10-3mm2/second;P=0.04].No significant difference was observed between papillary and chromophobe RCC(P=0.396).When grouped,ccRCC demonstrated a significantly higher mean ADC value compared with non-ccRCC[(1.391±0.271)×10-3mm2/second vs(0.915±0.312)×10-3mm2/second;P<0.001].Receiver operating characteristic analysis yielded an area under the curve of 0.889(95%confidence interval:0.804-0.975).An ADC threshold of 1.08×10-3mm2/second achieved 90%sensitivity and 83%specificity for identifying ccRCC.CONCLUSION DWI with quantitative ADC analysis reliably differentiates clear cell from non-ccRCC and demonstrates significant correlation with RCC subtype and tumor grade.DWI serves as a valuable adjunct to conventional MRI,particularly in patients with contraindications to contrast administration. 展开更多
关键词 Renal cell carcinoma Diffusion-weighted imaging Apparent diffusion coefficient Magnetic resonance imaging Tumor subtyping
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Apparent diffusion coefficient of kidneys with non-contrast magnetic resonance angiography for functional and anatomical assessment in renal artery stenosis 认领 引用
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作者 Hira Lal Surabhi Agarwal +7 位作者 Kaushik Ponmalai Raghunandan Prasad Dharmendra S Bhadauria Sanjay Gambhir Swagata Mandal Sandeep Kumar Priyank Yadav Pinky Jowel 《World Journal of Methodology》 2026年第1期198-210,共13页
BACKGROUND Renal artery stenosis(RAS)is a vascular disorder linked to secondary hypertension,chronic kidney disease,and renal failure due to interstitial fibrosis.Early diagnosis is crucial as RAS-induced hypertension... BACKGROUND Renal artery stenosis(RAS)is a vascular disorder linked to secondary hypertension,chronic kidney disease,and renal failure due to interstitial fibrosis.Early diagnosis is crucial as RAS-induced hypertension responds well to angioplasty.Non-invasive imaging techniques,including non-contrast magnetic resonance angiography(NC-MRA),help assess RAS without contrast-related risks.Diffusion-weighted MR imaging(DW-MRI)has emerged as a promising method for evaluating kidney function by measuring the apparent diffusion coefficient(ADC),which correlates with renal pathology.AIM To compare ADC values in hypertensive,RAS,and healthy kidneys,assess the correlation between ADC and stenosis severity,and evaluate its relationship with split glomerular filtration rate(GFR).METHODS This prospective observational study which included 86 patients with suspected RAS and twenty normal healthy controls underwent NC-MRA on a 3T-MR-Scanner followed by DW-MRI at b values of 0 and 1000 seconds/mm2 in the transverse plane.ADC maps were created using Functool.ADC values were measured in the cortex and medulla of each kidney's upper,middle,and lower pole,and the average ADC(ADCavg)for cortex and medulla calculated.In patients with RAS,degree of stenosis(DOS)was calculated on NC-MRA.The ADC of 212 kidneys was compared,and the relationship between DOS and ADC was established.In addition,split GFR was calculated in 30 kidneys using 99mTc-DTPA,and correlated with ADC value.The ADC values of kidneys with and without RAS were compared using the Student’s t-test.The correlation between ADC and stenosis severity was assessed by Spearman’s test,while the relationship between ADC and split GFR was evaluated using Pearson’s test.A P value<0.05 was considered statistically significant.RESULTS RAS was detected in 58 of 86(67.44%)hypertensive patients(81 of 172 kidneys),and the ADCavg(P=0.044)was significantly lower in RAS kidneys than in kidneys with normal arteries and essential hypertension and healthy controls.CONCLUSION DW-MRI can be a useful non-invasive technique to estimate the kidney’s functional status in RAS patients.It can be used as a complementary assessment tool with NC-MRA to triage patients in need of interventional management. 展开更多
关键词 Renal artery stenosis Diffusion weighted imaging Apparent diffusion coefficient Magnetic resonance imaging Non-contrast renal magnetic resonance angiography Hypertension
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Apparent diffusion coefficient by diffusion-weighted magnetic resonance imaging as a sole biomarker for staging and prognosis of gastric cancer 认领 引用 被引量：16
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作者 Francesco Giganti Alessandro Ambrosi +7 位作者 Damiano Chiari Elena Orsenigo Antonio Esposito Elena Mazza Luca Albarello Carlo Staudacher Alessandro Del Maschio Francesco De Cobelli 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2017年第2期118-126,共9页
Objective： To investigate the role of apparent diffusion coefficient （ADC） from diffusion-weighted magnetic resonance imaging （DW-MRI） when applied to the 7th TNM classification in the staging and prognosis of ga... Objective： To investigate the role of apparent diffusion coefficient （ADC） from diffusion-weighted magnetic resonance imaging （DW-MRI） when applied to the 7th TNM classification in the staging and prognosis of gastric cancer （GC）. Methods： Between October 2009 and May 2014, a total of 89 patients with non-metastatic, biopsy proven GC underwent 1.5T DW-MRI, and then treated with radical surgery. Tumor ADC was measured retrospectively and compared with final histology following the 7th TNM staging （local invasion, nodal involvement and according to the different groups -- stage Ⅰ, Ⅱ and Ⅲ）. Kaplan-Meier curves were also generated. The follow-up period is updated to May 2016. Results： Median follow-up period was 33 months and 45/89 （51%） deaths from GC were observed. ADC was significantly different both for local invasion and nodal involvement （P〈0.001）. Considering final histology as the reference standard, a preoperative ADC cut-offof 1.80×10-3 mm^2/s could distinguish between stages I and Ⅱ and an ADC value of ≤1.36-10-3 mm^2/s was associated with stage Ⅲ（P〈0.001）. Kaplan-Meier curves demonstrated that the survival rates for the three prognostic groups were significantly different according to final histology and ADC cut-offs （P〈0.001）. Conclusions： ADC is different according to local invasion, nodal involvement and the 7th TNM stage groups for GC, representing a potential, additional prognostic biomarker. The addition of DW-MRI could aid in the staging and risk stratification of GC. 展开更多
关键词 Apparent diffusion coefficient diffusion-weighted magnetic resonance imaging gastric cancer prognosis TNM staging
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Apparent diffusion coefficient values of normal testis and variations with age 认领 引用 被引量：8
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作者 Athina C Tsili Dimitrios Giannakis +4 位作者 Anastasios Sylakos Alexandra Ntorkou Loukas G Astrakas Nikolaos Sofikitis Maria I Argyropoulou 《Asian Journal of Andrology》 SCIE CAS CSCD 2014年第3期493-497,共5页
The usefulness of diffusion-weighted magnetic resonance imaging （DWI） in the evaluation of scrotal pathology has recently been reported. A standard reference of normal testicular apparent diffusion coefficient （ADC... The usefulness of diffusion-weighted magnetic resonance imaging （DWI） in the evaluation of scrotal pathology has recently been reported. A standard reference of normal testicular apparent diffusion coefficient （ADC） values and their variations with age is necessary when interpreting normal testicular anatomy and pathology. We evaluated 147 normal testes using DWI, including 71 testes from 53 men aged 20-39years （group 1）, 67 testes from 42 men aged 40-69 years （group 2） and nine testes from six men older than 70years （group 3）. DWI was performed along the axial plane, using a single shot, multislice spin-echo planar diffusion pulse sequence and b-values of 0 and 900 s mm-2. The mean and standard deviation of the ADC values of normal testicular parenchyma were calculated for each age group separately. Analysis of variance （ANOVA） followed by post hoc analysis （Dunnett T3） was used for statistical purposes. The ADC values （x 10-3 mm2s-1） of normal testicular tissue were different among age groups （group 1：1.08 ± 0.13; group 2：1.15 ±0.15 and group 3：1.31± 0.22）. ANOVA revealed differences in mean ADC among age groups （F= 11.391, P〈 0.001）. Post hoc analysis showed differences between groups 1 and 2 （P= 0.008） and between groups 1 and 3 （P= 0.043）, but not between groups 2 and 3 （P= 0.197）. Our findings suggest that ADC values of normal testicular tissue increase with advancing age. 展开更多
关键词 age apparent diffusion coefficient （ADC） diffusion-weighted magnetic resonance imaging testis
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Apparent diffusion coefficient in normal and abnormal pattern of intervertebral lumbar discs:initial experience 认领 引用 被引量：7
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作者 Gang Niu Xuewen Yu +3 位作者 Jian Yang Rong Wang Shaojuan Zhang Youmin Guo 《Journal of Biomedical Research》 CAS 2011年第3期197-203,共7页
The aim of the present study was to compare the relationship of morphologically defined non-bulging/herni-ated,bulging and herniated intervertebral lumbar discs with quantitative apparent diffusion coefficient(ADC).Th... The aim of the present study was to compare the relationship of morphologically defined non-bulging/herni-ated,bulging and herniated intervertebral lumbar discs with quantitative apparent diffusion coefficient(ADC).Thirty-two healthy volunteers and 28 patients with back pain or sciatica were examined by MRI.All intervertebral lumbar discs from L1 to S1 were classified according to morphological abnormality and degenerated grades.The ADC values of nucleus pulposus(NP)were measured and recorded.The significant differences about mean ADC values of NP were found between non-bulging/herniated discs and bulging discs as well as herniated discs(P 0.05),whereas there were no significant differences in ADC values between bulging and herniated discs(P 0.05).Moreover,statistically significant relationship was found in the mean ADC values of NP between"non-bulging/herniated and non-degenerated discs"and"non-bulging/herniated degenerated discs"as well as herniated discs(P 0.05).Linear regression analysis between ADC value and disc level revealed an inverse correlation(r=-0.18).The ADC map of the NP is a potentially useful tool for the quantitative assessment of componential and molecular alterations accompanied with lumbar disc abnormalities. 展开更多
关键词 intervertebral lumbar disc apparent diffusion coefficient disc bulging disc herniation
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Correlation of magnetic resonance imaging quantitative parameters and apparent diffusion coefficient value with pathological breast cancer 认领 引用 被引量：8
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作者 Zhe Wang Guan-Ying Ren +1 位作者 Qian Yin Qian Wang 《World Journal of Clinical Cases》 SCIE 2022年第21期7333-7340,共8页
BACKGROUND China ranks 120th worldwide for the incidence of breast cancer and 163rd for mortality.Early screening,diagnosis,and timely determination of the optimal treatment plan can help ensure clinical efficacy and ... BACKGROUND China ranks 120th worldwide for the incidence of breast cancer and 163rd for mortality.Early screening,diagnosis,and timely determination of the optimal treatment plan can help ensure clinical efficacy and prognosis.AIM To investigate the relationship between quantitative magnetic resonance imaging parameters,apparent diffusion coefficient value,pathological immunohistochemical status,and patient prognosis.METHODS A total of 108 patients with breast cancer(breast cancer group)and 110 patients with benign breast tumors(benign group)confirmed by pathological examination at our Hospital from September 2013 to August 2016 were selected.All patients had undergone preoperative magnetic resonance imaging(MRI)examinations,and the quantitative parameters of MRI and apparent diffusion coefficient(ADC)values for the two groups were compared.The MRI quantitative parameters and ADC values of patients with different estrogen receptor(ER),progesterone receptor,and human epidermal growth factor receptor-2 expression were statistically analyzed.The relationship between the quantitative parameters of MRI and ADC values and patient recurrence was analyzed using receiver operating curves.RESULTS The measured values of the quantitative parameters of MRI-Ktrans,Kep,and Ve in the breast cancer group were higher than those in the benign group;the ADC value in the breast cancer group was lower than that in the benign group,and the difference was statistically significant(P<0.05).The Ktrans,Ve,and ADC values in patients with ER-positive breast cancer were significantly lower than those in patients with negative ER expression(P<0.05).After 5 years of follow-up,22 patients with breast cancer experienced postoperative recurrence.The Kep,Ve,and ADC values of the recurrence group were significantly lower than those of the non-recurrence group,and the difference was statistically significant(P<0.05).CONCLUSION MRI quantitative parameters and ADC are related to the expression of breast cancer-related immunological receptor factors and have certain clinical value in assessing postoperative recurrence in patients. 展开更多
关键词 Magnetic resonance Apparent diffusion coefficient Breast cancer Immunohistochemistry Prognosis
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Early changes in apparent diffusion coefficient as an indicator of response to sorafenib in hepatocellular carcinoma 认领 引用 被引量：4
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作者 Yi-lei ZHAO Qing-qu GUO +1 位作者 Gen-ren YANG Qi-dong WANG 《Journal of Zhejiang University-SCIENCE B》 SCIE CAS CSCD 2014年第8期713-719,共7页
Objective： The relationship between apparent diffusion coefficient （ADC） and chemotherapy has been established. However, whether ADC could be considered as a measure for monitoring response to sorafenib in hepatoce... Objective： The relationship between apparent diffusion coefficient （ADC） and chemotherapy has been established. However, whether ADC could be considered as a measure for monitoring response to sorafenib in hepatocellular carcinoma （HCC） has not been demonstrated. This study was to investigate the ADC changes of ad- vanced HCC under sorafenib treatment. Methods： Athymic mice with HepG2 xenografts were allocated to two groups： control and sorafenib （40 mg/kg, bid）. T2 and diffusion images were acquired at each time point （0, 10, 14, and 18 d post-therapy）. Tumor volume and changes in ADC were calculated. Results： Tumor volumes on Days 10, 14, and 18 after treatment showed significant decreases in the sorafenib-treated group compared with the control. Pretreatment ADC values were not significantly different between the control and treated groups. A slow increase in ADC in the peripheral zone of tumors appeared in the treated group, which was significantly higher compared with the control group on Days 10, 14, and 18. In the central part of tumors on Day 10 after treatment, an increase in ADC appeared in the treated and control groups, the ADC of the control group being significantly lower compared with the treated tumors From Day 10 to Day 14, the ADC map showed a progressive decrease in the central region of tumors in the treated and control groups. However, this change is more significant in the treated groups. Conclusions： Early changes in mean ADC correlated with sorafenib treatment in HCC, which are promising indicators for predicting sorafenib response in this carcinoma. 展开更多
关键词 Hepatocellular carcinoma Sorafenib Apparent diffusion coefficient Magnetic resonance imaging （MRI）
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The apparent diffusion coefficient does not reflect cytotoxic edema on the uninjured side after traumatic brain injury 认领 引用 被引量：2
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作者 Hong Lu Xiaoyan Lei 《Neural Regeneration Research》 SCIE CAS CSCD 2014年第9期973-977,共5页
After traumatic brain injury, vasogenic and cytotoxic edema appear sequentially on the involved side. Neuroimaging investigations of edema on the injured side have employed apparent diffusion coefficient measurements ... After traumatic brain injury, vasogenic and cytotoxic edema appear sequentially on the involved side. Neuroimaging investigations of edema on the injured side have employed apparent diffusion coefficient measurements in diffusion tensor imaging. We investigated the changes occurring on the injured and uninjured sides using diffusion tensor imaging/apparent diffusion coefficient and histological samples in rats. We found that, on the injured side, that vasogenic edema appeared at 1 hour and intracellular edema appeared at 3 hours. Mixed edema was observed at 6 hours, worsening until 12–24 hours post-injury. Simultaneously, microglial cells proliferated at the trauma site. Apparent diffusion coefficient values increased at 1 hour, decreased at 6 hours, and increased at 12 hours. The uninjured side showed no significant pathological change at 1 hour after injury. Cytotoxic edema appeared at 3 hours, and vasogenic edema was visible at 6 hours. Cytotoxic edema persisted, but vasogenic edema tended to decrease after 12–24 hours. Despite this complex edema pattern on the uninjured side with associated pathologic changes, no significant change in apparent diffusion coefficient values was detected over the first 24 hours. Apparent diffusion coefficient values accurately detected the changes on the injured side, but did not detect the changes on the uninjured side, giving a false-negative result. 展开更多
关键词 nerve regeneration brain injuries blood-brain barrier magnetic resonance imaging apparent diffusion coefficient intracranial edema cytotoxic edema vasogenic edema pathology NSFC grant neural regeneration
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Textural differences based on apparent diffusion coefficient maps for discriminating pT3 subclasses of rectal adenocarcinoma 认领 引用 被引量：1
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作者 Zhi-Hua Lu Kai-Jian Xia +2 位作者 Heng Jiang Jian-Long Jiang Mei Wu 《World Journal of Clinical Cases》 SCIE 2021年第24期6987-6998,共12页
BACKGROUND The accuracy of discriminating pT3a from pT3b-c rectal cancer using highresolution magnetic resonance imaging(MRI)remains unsatisfactory,although texture analysis(TA)could improve such discrimination.AIM To... BACKGROUND The accuracy of discriminating pT3a from pT3b-c rectal cancer using highresolution magnetic resonance imaging(MRI)remains unsatisfactory,although texture analysis(TA)could improve such discrimination.AIM To investigate the value of TA on apparent diffusion coefficient(ADC)maps in differentiating pT3a rectal adenocarcinomas from pT3b-c tumors.METHODS This was a case-control study of 59 patients with pT3 rectal adenocarcinoma,who underwent diffusion-weighted imaging(DWI)between October 2016 and December 2018.The inclusion criteria were:(1)Proven pT3 rectal adenocarcinoma;(2)Primary MRI including high-resolution T2-weighted image(T2WI)and DWI;and(3)Availability of pathological reports for surgical specimens.The exclusion criteria were:(1)Poor image quality;(2)Preoperative chemoradiation therapy;and(3)A different pathological type.First-order(ADC values,skewness,kurtosis,and uniformity)and second-order(energy,entropy,inertia,and correlation)texture features were derived from whole-lesion ADC maps.Receiver operating characteristic curves were used to determine the diagnostic value for pT3b-c tumors.RESULTS The final study population consisted of 59 patients(34 men and 25 women),with a median age of 66 years(range,41-85 years).Thirty patients had pT3a,24 had pT3b,and five had pT3c.Among the ADC first-order textural differences between pT3a and pT3b-c rectal adenocarcinomas,only skewness was significantly lower in the pT3a tumors than in pT3b-c tumors.Among the ADC second-order textural differences,energy and entropy were significantly different between pT3a and pT3b-c rectal adenocarcinomas.For differentiating pT3a rectal adenocarcinomas from pT3b-c tumors,the areas under the curves(AUCs)of skewness,energy,and entropy were 0.686,0.657,and 0.747,respectively.Logistic regression analysis of all three features yielded a greater AUC(0.775)in differentiating pT3a rectal adenocarcinomas from pT3b-c tumors(69.0%sensitivity and 83.3%specificity).CONCLUSION TA features derived from ADC maps might potentially differentiate pT3a rectal adenocarcinomas from pT3b-c tumors. 展开更多
关键词 Diffusion-weighted imaging Apparent diffusion coefficient Rectal cancer Cancer stage Texture analysis case-control study
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Diffusion-weighted magnetic resonance imaging in cancer: Reported apparent diffusion coefficients,in-vitro and invivo reproducibility 认领 引用 被引量：2
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作者 Maysam M Jafar Arman Parsai Marc E Miquel 《World Journal of Radiology》 2016年第1期21-49,共29页
There is considerable disparity in the published apparent diffusion coefficient(ADC)values across different anatomies.Institutions are increasingly assessing repeatability and reproducibility of the derived ADC to det... There is considerable disparity in the published apparent diffusion coefficient(ADC)values across different anatomies.Institutions are increasingly assessing repeatability and reproducibility of the derived ADC to determine its variation,which could potentially be used as an indicator in determining tumour aggressiveness or assessing tumour response.In this manuscript,a review of selected articles published to date in healthy extracranial body diffusion-weighted magnetic resonance imaging is presented,detailing reported ADC values and discussing their variation across different studies.In total 115 studies were selected including 28 for liver parenchyma,15 for kidney(renal parenchyma),14 for spleen,13 for pancreatic body,6 for gallbladder,13 for prostate,13 for uterus(endometrium,myometrium,cervix)and 13 for fibroglandular breast tissue.Median ADC values in selected studies were found to be 1.28×10-3 mm2/s in liver,1.94×10-3 mm2/s in kidney,1.60×10-3 mm2/s in pancreatic body,0.85×10-3 mm2/s in spleen,2.73×10-3 mm2/s in gallbladder,1.64×10-3 mm2/s and 1.31×10-3 mm2/s in prostate peripheral zone and central gland respectively(combined median value of 1.54×10-3 mm2/s),1.44×10-3 mm2/s in endometrium,1.53×10-3 mm2/s in myometrium,1.71×10-3 mm2/s in cervix and 1.92×10-3 mm2/s in breast.In addition,six phantom studies and thirteen in vivo studies were summarized to compare repeatability and reproducibility of the measured ADC.All selected phantom studies demonstrated lower intra-scanner and inter-scanner variation compared to in vivo studies.Based on the findings of this manuscript,it is recommended that protocols need to be optimised for the body part studied and that system-induced variability must be established using a standardized phantom in any clinical study.Reproducibility of the measured ADC must also be assessed in a volunteer population,as variations are far more significant in vivo compared with phantom studies. 展开更多
关键词 Diffusion-weighted magnetic resonance imaging Apparent diffusion coefficient reproducibility Apparent diffusion coefficient Cancer imaging Extra-cranial organsA
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Whole lesion histogram analysis of apparent diffusion coefficient predicts therapy response in locally advanced rectal cancer 认领 引用 被引量：11
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作者 Mayra Evelia Jiménez de los Santos Juan Armando Reyes-Pérez +4 位作者 Victor Domínguez Osorio Yolanda Villaseñor-Navarro Liliana Moreno-Astudillo Itzel Vela-Sarmiento Isabel Sollozo-Dupont 《World Journal of Gastroenterology》 SCIE CAS 2022年第23期2609-2624,共16页
BACKGROUND Whole-tumor apparent diffusion coefficient(ADC)histogram analysis is relevant to predicting the neoadjuvant chemoradiation therapy(nCRT)response in patients with locally advanced rectal cancer(LARC).AIM To ... BACKGROUND Whole-tumor apparent diffusion coefficient(ADC)histogram analysis is relevant to predicting the neoadjuvant chemoradiation therapy(nCRT)response in patients with locally advanced rectal cancer(LARC).AIM To evaluate the performance of ADC histogram-derived parameters for predicting the outcomes of patients with LARC.METHODS This is a single-center,retrospective study,which included 48 patients with LARC.All patients underwent a pre-treatment magnetic resonance imaging(MRI)scan for primary tumor staging and a second restaging MRI for response evaluation.The sample was distributed as follows:18 responder patients(R)and 30 non-responders(non-R).Eight parameters derived from the whole-lesion histogram analysis(ADCmean,skewness,kurtosis,and ADC10th,25th,50th,75th,90th percentiles),as well as the ADCmean from the hot spot region of interest(ROI),were calculated for each patient before and after treatment.Then all data were compared between R and non-R using the Mann-Whitney U test.Two measures of diagnostic accuracy were applied:the receiver operating characteristic curve and the diagnostic odds ratio(DOR).We also reported intra-and interobserver variability by calculating the intraclass correlation coefficient(ICC).RESULTS Post-nCRT kurtosis,as well as post-nCRT skewness,were significantly lower in R than in non-R(both P<0.001,respectively).We also found that,after treatment,R had a larger loss of both kurtosis and skewness than non-R(Δ%kurtosis and Δ skewness,P<0.001).Other parameters that demonstrated changes between groups were post-nCRT ADC10th,Δ%ADC10th,Δ%ADCmean,and ROIΔ%ADCmean.However,the best diagnostic performance was achieved byΔ%kurtosis at a threshold of 11.85%(Area under the receiver operating characteristic curve[AUC]=0.991,DOR=376),followed by post-nCRT kurtosis=0.78×10-3mm2/s(AUC=0.985,DOR=375.3),Δskewness=0.16(AUC=0.885,DOR=192.2)and post-nCRT skewness=1.59×10-3mm2/s(AUC=0.815,DOR=168.6).Finally,intraclass correlation coefficient analysis showed excellent intraobserver and interobserver agreement,ensuring the implementation of histogram analysis into routine clinical practice.CONCLUSION Whole-tumor ADC histogram parameters,particularly kurtosis and skewness,are relevant biomarkers for predicting the nCRT response in LARC.Both parameters appear to be more reliable than ADCmean from one-slice ROI. 展开更多
关键词 Apparent diffusion coefficient Diffusion-weighted imaging Histogram analysis Magnetic resonance imaging Locally advanced rectal cancer
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Apparent diffusion coefficient evaluation for secondary changes in the cerebellum of rats after middle cerebral artery occlusion 认领 引用 被引量：3
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作者 Yunjun Yang Lingyun Gao +5 位作者 Jun Fu Jun Zhang Yuxin Li Bo Yin Weijian Chen Daoying Geng 《Neural Regeneration Research》 SCIE CAS CSCD 2013年第31期2942-2950,共9页
Supratentorial cerebral infarction can cause functional inhibition of remote regions such as the cerebellum, which may be relevant to diaschisis. This phenomenon is often analyzed using positron emission tomography an... Supratentorial cerebral infarction can cause functional inhibition of remote regions such as the cerebellum, which may be relevant to diaschisis. This phenomenon is often analyzed using positron emission tomography and single photon emission CT. However, these methods are expensive and radioactive. Thus, the present study quantified the changes of infarction core and remote regions after unilateral middle cerebral artery occlusion using apparent diffusion coefficient values. Diffu- sion-weighted imaging showed that the area of infarction core gradually increased to involve the cerebral cortex with increasing infarction time. Diffusion weighted imaging signals were initially in- creased and then stabilized by 24 hours. With increasing infarction time, the apparent diffusion co- efficient value in the infarction core and remote bilateral cerebellum both gradually decreased, and then slightly increased 3-24 hours after infarction. Apparent diffusion coefficient values at remote regions （cerebellum） varied along with the change of supratentorial infarction core, suggesting that the phenomenon of diaschisis existed at the remote regions. Thus, apparent diffusion coefficient values and diffusion weighted imaging can be used to detect early diaschisis. 展开更多
关键词 neural regeneration brain injury cerebral ischemia cerebral infarction magnetic resonanceimaging apparent diffusion coefficient middle cerebral artery occlusion diffusion weighted imaging infarction core remote regions diaschisis grants-supported paper neuroregeneration
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Value of Apparent Diffusion Coefficient(ADC) of Diffusion eighted Magnetic Resonance Imaging in Common Renal Disease Diagnosis 认领 引用
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作者 Yuelang Zhang Xingwang Sun Guangnan Quan Yongqian Qiang Chenxia Li 《Journal of Nanjing Medical University》 2008年第6期362-365,共4页
Objective：To find the value of the apparent diffusion coefficient （ADC） of diffusion weighted magnetic resonance imaging of common renal diseases. Methods： There were 30 healthy subjects and 81 patients with renal... Objective：To find the value of the apparent diffusion coefficient （ADC） of diffusion weighted magnetic resonance imaging of common renal diseases. Methods： There were 30 healthy subjects and 81 patients with renal lesions （56 cases of renal carcinoma, 18 lesions of 12 cases of renal angiomyolipomal and 21 lesions of 13 cases of renal cysts）. Conventional magnetic resonance imaging and diffusion weighted magnetic resonance imaging were carried out. We measured the average ADC value of the renal lesions and normal kidneys. ADC maps from different b values were generated by a statistical package. Results： The ADC values of normal kidneys with three different motion-probing gradients（b=500, 800, 1000 sec/mm^2） were 2.78 ± 0.14 × 10^-3mm^2s^-1, 2.45 ± 0.13 × 10^3mm^2s^-1, 2.13 ± 0.14 × 10^-3mm^2s^-1, respectively. The ADC values of renal cell carcinoma with three different motion-probing gradients（b=500, 800, 1000 sec/mm^2） were 1.63 ± 0.14 × 10^3mm^2s^-1, 1.31 ± 0.18 × 10^3mm^2s^-, 1.07 ± 0.15 × 10^-3mm^2s^-1, respectively. Among the renal cell carcinoma, the ADC value of clear cell type were 1.67 ± 0.09 × 10^3mm^2s^-1, 1.36 ± 0.13 × 10^3mm^2s^-1, 1.15 ± 0.14 × 10^3mm^2s^-1,respectively; the ADC values of granular cell type were 1.59±0.19 × 10^3mm^2s^-1, 1.25 ± 0.22 × 10^3mm^2s^-1, 0.97 ± 0.12 × 10^3mm^2s^-1, respectively. The ADC values of renal angiomyolipoma with three different motion-probing gradients（b=500, 800,1000 sec/mm^2） were 0.88 ± 0.08 × 10^3mm^2s^-1, 0.63 ± 0.07 × 10^3mm^2s^-1, 0.43 ± 0.04 × 10^3mm^2s^-1, respectively. The ADC values of renal cystic lesions with three different motionprobing gradients（b=500, 800, 1000 sec/mm^2） were 3.73 ± 0.18 × 10^3mm^2s^-1, 3.44 ± 0.13 × 10^3mm^2s^-1, 3.09± 0.21 × 10^3mm^2s^-1, respectively. Statistically significant differences exists between the ADC values of normal kidney, renal carcinomas, renal angiomyolipomas and renal cysts when the b value is the same. Among the different cell types of renal carcinomas, the ADC value of granular cell carcinoma is lower than that of clear cell carcinomas. Conclusion： It is of benefit in diagnosing and distinguishing between benign and malignant renal tumors to know the ADC values in diffusion weighted magnetic resonance imaging. Furthermore, these values help to know the internal structure of the tumor and the tumor typel, which is helpful to the treatment and in predicting the patient＇ s prognosis. 展开更多
关键词 Diffusion weighted imaging apparent diffusion coefficient renal cell carcinoma renal angiomyolipoma Renal cyst
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Difference Analysis of MRI Apparent Diffusion Coefficient and R2*Value Between Small Hepatocellular Carcinoma and Cirrhosis Nodules 认领 引用
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作者 Man Li Haiquan Wang 《Advances in Modern Oncology Research》 2020年第2期21-24,共4页
Objective:To investigate the differences of apparent diffusion coefficient and transverse relaxation rate(R2*)in magnetic resonance imaging(MRI)between micro hepatocellular carcinoma and nodules of cirrhosis.Met... Objective:To investigate the differences of apparent diffusion coefficient and transverse relaxation rate(R2*)in magnetic resonance imaging(MRI)between micro hepatocellular carcinoma and nodules of cirrhosis.Method:The clinical data of 68 patients with micro hepatocellular carcinoma(76 lesions)and 45 patients with nodular cirrhosis(48 lesions)were retrospectively analyzed.Diffusion weighted imaging and R2*imaging were performed on all patients.The differences of apparent diffusion coefficient and R2*values in patients with micro hepatocellular carcinoma and nodular cirrhosis were compared.Receiver operating characteristic(ROC)curves were drawn to evaluate the diagnostic efficacy of apparent diffusion coefficient values and R2*values for microhepatocellular carcinoma.Result:Compared with nodules of cirrhosis,the mean apparent diffusion coefficient and R2*value of micro-hepatocellular carcinoma were significantly decreased(P<0.05).The diagnosis threshold of apparent diffusion coefficient is at 1.35×10-3mm2/s,and the sensitivity for the diagnosis of micro-hepatocellular carcinoma was 80.88%,and the specificity was 91.11%,and the corresponding area under the ROC curve was 0.88;The diagnostic threshold for R2*value was at 53.96 Hz,and the sensitivity for the diagnosis of small hepatocellular carcinoma was 91.18%,and the specificity was 77.78%,and the corresponding area under the ROC curve was 0.84.Conclusion:MRI apparent diffusion coefficient value and R2*value can be used to differentiate and diagnose micro hepatocellular carcinoma and nodules of cirrhosis,in which the apparent diffusion coefficient of nodules of cirrhosis was less than 1.35×10-3mm2/s,R2*values were lower than 53.96 Hz may indicate the occurrence of nodular canceration. 展开更多
关键词 Small liver cancer Cirrhosis nodules Magnetic resonance imaging Apparent diffusion coefficient Transverse relaxation rate
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Texture analysis of apparent diffusion coefficient maps:can it identify nonresponse to neoadjuvant chemotherapy for additional radiation therapy in rectal cancer patients? 认领 引用 被引量：2
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作者 Qianyu Wu Yongju Yi +6 位作者 Bingjia Lai Jiao Li Yanbang Lian Junhong Chen Yue Wu Xinhua Wang Wuteng Cao 《Gastroenterology Report》 SCIE CSCD 2024年第1期183-190,共8页
Background:Neoadjuvant chemotherapy(NCT)alone can achieve comparable treatment outcomes to chemoradiotherapy in locally advanced rectal cancer(LARC)patients.This study aimed to investigate the value of texture analysi... Background:Neoadjuvant chemotherapy(NCT)alone can achieve comparable treatment outcomes to chemoradiotherapy in locally advanced rectal cancer(LARC)patients.This study aimed to investigate the value of texture analysis(TA)in apparent diffusion coefficient(ADC)maps for identifying non-responders to NCT.Methods:This retrospective study included patients with LARC after NCT,and they were categorized into nonresponse group(pTRG 3)and response group(pTRG 0-2)based on pathological tumor regression grade(pTRG).Predictive texture features were extracted from pre-and post-treatment ADC maps to construct a TA model using RandomForest.The ADC model was developed by manually measuring pre-and post-treatment ADC values and calculating their changes.Simultaneously,subjective evaluations based on magnetic resonance imaging assessment of TRG were performed by two experienced radiologists.Model performance was compared using the area under the curve(AUC)and DeLong test.Results:A total of 299 patients from two centers were divided into three cohorts:the primary cohort(center A;n=194,with 36 non-responders and 158 responders),the internal validation cohort(center A;n=49,with 9 non-responders)and external validation cohort(center B;n=56,with 33 non-responders).The TA model was constructed by post_mean,mean_change,post_skewness,post_entropy,and entropy_change,which outperformed both the ADC model and subjective evaluations with an impressive AUC of 0.997(95%confidence interval[CI],0.975-1.000)in the primary cohort.Robust performances were observed in internal and external validation cohorts,with AUCs of 0.919(95%CI,0.805-0.978)and 0.938(95%CI,0.840-0.985),respectively.Conclusions:The TA model has the potential to serve as an imaging biomarker for identifying nonresponse to NCT in LARC patients,providing a valuable reference for these patients considering additional radiation therapy. 展开更多
关键词 locally advanced rectal cancer texture analysis apparent diffusion coefficient
Coronal Diffusion-weighted Magnetic Resonance Imaging of the Kidney: Agreement with Axial Diffusion-weighted Magnetic Imaging in Terms of Apparent Diffusion Coefficient Values 认领 引用
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作者 Hai-Yi Wang Jia Wang +2 位作者 Ye-Huan Tang Hui-Yi Ye Lin Ma 《Chinese Medical Journal》 SCIE CAS CSCD 2015年第4期499-503,共5页
Background：Coronal diffusion-weighted magnetic resonance imaging （DW-MRI） and apparent diffusion coefficient （ADC） values have gradually become applied （following conventional axial DW-MRI） in the renal analysi... Background：Coronal diffusion-weighted magnetic resonance imaging （DW-MRI） and apparent diffusion coefficient （ADC） values have gradually become applied （following conventional axial DW-MRI） in the renal analysis.To explore whether data obtained using coronal DW-MRI are comparable with those derived using axial DW-MRI,this preliminary study sought to assess the agreement in renal ADC values between coronal DW-MRI and axial DW-MRI.Methods：Thirty-four healthy volunteers were enrolled in the study; written consents were obtained.All subjects underwent respiratory-triggered axial and coronal DW-MRI using a 1.5-MR system with b values of 0 and 800 s/mm2.The signal-to-noise ratios （SNRs） of the two DW-MRI sequences were measured and statistically compared using the paired t-test.The extent of agreement of ADC values of the upper pole,mid-pole,and lower pole of the kidney; the mean ADC values of the left kidney and right kidney; and the mean ADC values of the bilateral kidneys were evaluated via calculation of intraclass correlation coefficients （ICCs） or Bland-Altman method between the two DW-MRI sequences.Results：The SNR of coronal DW-MR images was statistically inferior to that of axial DW-MR images （P ＜ 0.001）.The ICCs of the ADC values of each region of interest,and the mean ADC values of bilateral kidneys,between the two sequences,were greater than 0.5,and the mean ADCs of the bilateral kidneys demonstrated the highest ICC （0.869; 95％ confidence interval：0.739-0.935）.In addition,94.1％ （32/34）,94.1％ （32/34）,and 97.1％ （31/34） of the ADC bias was inside the limits of agreement in terms of the mean ADC values of the left kidneys,right kidneys,and bilateral kidneys when coronal and axial DWI-MRI were compared.Conclusions：ADC values derived using coronal DW-MRI exhibited moderate-to-good agreement to those of axial DW-MRI,rendering the former an additional useful DW-MRI method,and causing the ADC values derived using the two types of DW-MRI to be comparable. 展开更多
关键词 Apparent Diffusion Coefficient Diffusion-weighted Magnetic Resonance Imaging Humans Kidney Magnetic Resonance Imaging
Relative apparent diffusion coefficient: a promising tool to differentiate metastatic from benign lymph nodes in animal models 认领 引用 被引量：12
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作者 XING Wei SHENG Jing +2 位作者 CHEN Jie TIAN Jian-ming BI Heng-liang 《Chinese Medical Journal》 SCIE CAS CSCD 2011年第18期2907-2910,共4页
Background Diffusion-weighted imaging has been widely used to differentiate the character of lymphadenopathy. But there are significant differences between prior studies. The aim of the study was to compare the benefi... Background Diffusion-weighted imaging has been widely used to differentiate the character of lymphadenopathy. But there are significant differences between prior studies. The aim of the study was to compare the benefit of apparent diffusion coefficient （ADC） and rADC in the differentiation of metastatic and benign lymph nodes in a rabbit model. Methods Two observers independently measured ADCs in quadriceps of every rabbit on diffusion-weighted images with different sizes of regions of interest （ROI）. The appropriate ROI for rADC was determined using the interobserver coefficient, rADC was calculated by AOClesion/AOCreference site- Receiver operating characteristics （ROC） analysis was performed to compare the diagnostic value of the ADC values and rADC values in differentiating metastatic from benign lymph nodes. Results When the ROIs included five pixels, the ICC was 0.816, indicating a good interobserver agreement. The differences of ADC and rADC values between metastatic and benign lymph nodes were both statistically significant. The area under the ROC curve was greater for the rADC than for the ADC. With the rADC criteria of 0.640, the sensitivity and specificity for differentiating metastatic from benign lymph nodes were 93% and 90%, respectively. Conclusion As a reference site, muscles reveal a good repeatability using a small ROI and the rADC may improve diagnostic accuracy for detecting metastatic nodes in animal models. 展开更多
关键词 diffusion-weighted imaging magnetic resonance imaging apparent diffusion coefficient relative ADC lymph nodes VX2
Prostatic abscess and seminal vesicle abscess:MRI findings and quantitative analysis of apparent diffusion coefficient values 认领 引用
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作者 Jing Ren Xufang Huang +6 位作者 He Wang Huijia Liu Fang Ren Zhuoli Zhang Yong Yang Hong Yin Yi Huan 《Radiology of Infectious Diseases》 2015年第1期27-32,共6页
Purpose:To investigate the conventional magnetic resonance imaging(MRI)and diffusion-weighted imaging(DWI)findings of prostatic abscess(PA)and seminal vesicle abscess(SVA),and to evaluate the qualitative and quantitat... Purpose:To investigate the conventional magnetic resonance imaging(MRI)and diffusion-weighted imaging(DWI)findings of prostatic abscess(PA)and seminal vesicle abscess(SVA),and to evaluate the qualitative and quantitative diagnostic value of apparent diffusion coefficient(ADC)for these conditions.Materials and methods:Ten patients with PA and 2 patients with SVA who underwent MRI and DWI examinations(b=0 and 1000 s/mm2)at our institution were enrolled in this study.The diagnoses of all the patients were pathologically and clinically proved.Their conventional MRI and DWI images as well as ADC values were analyzed.The ADC values between PA and surrounding prostate tissues were compared using t test.Statistical significance was inferred at P<0.05.Results:Six patients were revealed with multiple foci.The other 6 showed singular lesion,including the 2 with SVA.A total of 23 focal abscesses were demonstrated with iso-low T1WI signal as well as hyperintense T2WI and DWI signals.Four patients with PA presented air within the lesions by both T1WI and T2WI.The mean ADCs of PA,(0.618±0.192)×10-3mm2s-1,were significantly lower than that of surrounding prostate tissues,(1.417±0.147)×10-3mm2s-1(P=0.000).Conclusion:PA and SVA can be characteristically demonstrated by MRI,and the lesions show especially restricted diffusion by DWI with low ADC values.These demonstrations facilitate their qualitative and quantitative diagnosis. 展开更多
关键词 Apparent diffusion coefficient Diffusion weighted imaging Magnetic resonance imaging Prostatic abscess Seminal vesicle abscess
Comparative Study on the Efficiency of Magnetic Resonance Diffusion-Weighted Imaging in Differentiating Benign and Malignant Intracranial Mass Lesions 认领 引用
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作者 HAN Xiaojing SUN Di 《外文科技期刊数据库（文摘版）医药卫生》 2026年第5期149-153,共5页
Objective: To investigate the efficacy and accuracy of quantitative parameters and visual features in magnetic resonance diffusion-weighted imaging (MRI DWI) for distinguishing between benign and malignant intracrania... Objective: To investigate the efficacy and accuracy of quantitative parameters and visual features in magnetic resonance diffusion-weighted imaging (MRI DWI) for distinguishing between benign and malignant intracranial space-occupying lesions. Methods: A total of 100 patients with intracranial space-occupying lesions were enrolled in this study from January 2024 to January 2026. All participants underwent standardized head MRI scans including DWI sequences prior to surgery. During the study, regions of interest were delineated within the solid areas of lesions to obtain their mean apparent diffusion coefficient (ADC) values. Additionally, two experienced radiologists independently assessed the diffusion signal characteristics and contour features of the lesions, with the final pathological diagnosis serving as the gold standard. Differences in various observation parameters between benign and malignant lesions were compared. Results: The group of lesions diagnosed as malignant (n=52) exhibited a mean ADC value of (0.72±0.15)×10⁻³ mm²/s, whereas the benign group (n=48) showed a mean value of (1.21±0.28)×10⁻³ mm²/s; the difference was statistically significant (P<0.01). Imaging feature analysis revealed that malignant lesions more frequently demonstrated significant diffusion restriction and ill-defined infiltrative growth patterns. When setting the ADC diagnostic threshold at 0.89×10⁻³ mm²/s, the sensitivity and specificity for differentiating benign from malignant lesions were evaluated. The values reached 90.4% and 83.3%, respectively, with a area under the receiver operating characteristic curve equal to 0.92. Conclusion: The combined application of quantitative ADC measurement via magnetic resonance diffusion-weighted imaging (MRI DWI) and morphological feature analysis particularly provides a relatively objective and efficient imaging reference for non-invasively assessing the nature of intracranial space-occupying lesions prior to surgery. 展开更多
关键词 Magnetic resonance imaging Diffusion-weighted imaging Apparent diffusion coefficient Intracranial space-occupying lesions Differentiation between benign and malignant lesions
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Image Quality Stability of Whole-body Diffusion Weighted Imaging 认领 引用 被引量：1
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作者 Yun-bin Chen Chun-miao Hu +1 位作者 Jing Zhong Fei Sun 《Chinese Medical Sciences Journal》 CAS 2009年第2期122-126,共5页
Objective To assess the reproducibility of whole-body diffusion weighted imaging(WB-DWI) technique in healthy volunteers under normal breathing with background body signal suppression.Methods WB-DWI was performed on 3... Objective To assess the reproducibility of whole-body diffusion weighted imaging(WB-DWI) technique in healthy volunteers under normal breathing with background body signal suppression.Methods WB-DWI was performed on 32 healthy volunteers twice within two-week period using short TI inversion-recovery diffusion-weighted echo-planar imaging sequence and built-in body coil.The volunteers were scanned across six stations continuously covering the entire body from the head to the feet under normal breathing.The bone apparent diffusion coefficient(ADC) and exponential ADC(eADC) of regions of interest(ROIs) were measured.We analyzed correlation of the results using paired-t-test to assess the reproducibility of the WB-DWI technique.Results We were successful in collecting and analyzing data of 64 WB-DWI images.There was no significant difference in bone ADC and eADC of 824 ROIs between the paired observers and paired scans(P>0.05).Most of the images from all stations were of diagnostic quality.Conclusion The measurements of bone ADC and eADC have good reproducibility.WB-DWI technique under normal breathing with background body signal suppression is adequate. 展开更多
关键词 whole-body diffusion weighted imaging reproducibility bone apparent diffusion coefficient exponential apparent diffusion coefficient
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