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Message from the Guest Editor for the Special Issue on Biomaterials and Bioengineering 认领 引用
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作者 Li Jingchao 《Journal of Donghua University(English Edition)》 CAS 2026年第3期1-2,共2页
Dear Readers,Authors,and Colleagues,We are very pleased to present Issue 3,2026 of the Journal of Donghua University(English Edition),a special issue on biomaterials and bioengineering.This issue focuses on new ideas ... Dear Readers,Authors,and Colleagues,We are very pleased to present Issue 3,2026 of the Journal of Donghua University(English Edition),a special issue on biomaterials and bioengineering.This issue focuses on new ideas at the intersection of biomaterials and bioengineering.It brings together recent work from Donghua University and its partners in areas like biomaterials,molecular biology,smart healthcare,and microbial engineering.These studies not only follow our journal’s goal of supporting innovation and real-world applications but also show China’s growing strength in original research and practical breakthroughs in biomaterials and bioengineering. 展开更多
关键词 innovation microbial engineeringthese real world applications smart healthcare original research biomaterials biomaterialsmolecular biologysmart bioengineering
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Bridging bioengineering and nanotechnology: Bone marrow derived mesenchymal stem cell-exosome solutions for peripheral nerve injury 认领 引用 被引量：1
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作者 Jun Chang Xiu-Mei Yin +2 位作者 Man Zhang Jian-Wei Liu Lan Zhao 《World Journal of Stem Cells》 SCIE 2025年第1期80-85,共6页
Peripheral nerve injury(PNI)is a common disease that is difficult to nerve regeneration with current therapies.Fortunately,Zou et al demonstrated the role and mechanism of bone marrow derived mesenchymal stem cells(BM... Peripheral nerve injury(PNI)is a common disease that is difficult to nerve regeneration with current therapies.Fortunately,Zou et al demonstrated the role and mechanism of bone marrow derived mesenchymal stem cells(BMSCs)in promoting nerve regeneration,revealing broad prospects for BMSCs trans-plantation in alleviating PNI.We confirmed the fact that BMSCs significantly alleviate PNI,but there are shortcomings such as low cell survival rate and immune rejection,which limit the wide application of BMSCs.BMSCs-derived exosomes(Exos)are considered as a promising cell-free nanomedicine for PNI,avoiding the ethical issues of BMSCs.Exos in combination with bioengineering therapeutics(including extracellular matrix,hydrogel)brings new hope for PNI,provides a favorable microenvironment for neurological restoration and a therapeutic strategy with a favorable safety profile,significantly increases ex-pression of neurotrophic factors,promotes axonal and myelin regeneration,and demonstrates a strong potential to enhance neurogenesis.Therefore,engineered Exos exhibit better properties,such as stronger targeting and more beneficial components.This article briefly describes the role of nanotechnology and bioe-ngineering therapies for BMSCs in PNI,proposes clinical application prospects and challenges of nanotechnology and bioengineering BMSCs-derived Exos in PNI to improve the efficacy of BMSCs in the treatment of PNI. 展开更多
关键词 Mesenchymal stem cells Peripheral nerve injury Nanotechnology Exosome Bioengineering MicroRNA
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Starch biosynthesis and crop bioengineering 认领 引用
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作者 Andreas Blennow Kim Henrik Hebelstup Bent Larsen Petersen 《Grain & Oil Science and Technology》 EI CAS 2025年第3期235-245,共11页
Starch is an essential commodity for humans and other animals.Future demands require qualitative and quantitative improvement by crop and post-harvest engineering that calls for comprehensive actions requiring increas... Starch is an essential commodity for humans and other animals.Future demands require qualitative and quantitative improvement by crop and post-harvest engineering that calls for comprehensive actions requiring increased fundamental knowledge on starch biosynthesis,development of advanced breeding strategies,efficient farming,and well-adapted and up scalable extraction protocols for diverse starch products.Recent staggering progress in molecular breeding techniques,especially genome editing,have enabled generation of higher starch yield and special functional qualities required to support such advancement.However,this necessitates fundamental biochemical and mechanistic understanding of starch biosynthesis and the variegated starch crop germplasms,all of which are closely linked to the relationships between starch molecular structures and functionality of various starch types as directed by the different capabilities of starch crop genotypes.We here review starch biosynthesis and its genetic foundation with a focus on increasing nutritional and health-promoting value of starch especially through bioengineering of the high amylose trait. 展开更多
关键词 Starch Amylose Starch biosynthesis Bioengineering Resistant starch Starch crops
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Crisis in the gut:navigating gastrointestinal challenges in Gulf War Illness with bioengineering 认领 引用 被引量：2
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作者 Claudia A.Collier Aelita Salikhova +2 位作者 Sufiyan Sabir Steven Foncerrada Shreya A.Raghavan 《Military Medical Research》 SCIE CAS CSCD 2025年第5期641-658,共18页
Gulf War Illness(GWI)is characterized by a wide range of symptoms that manifests largely as gastrointestinal symptoms.Among these gastrointestinal symptoms,motility disorders are highly prevalent,presenting as chronic... Gulf War Illness(GWI)is characterized by a wide range of symptoms that manifests largely as gastrointestinal symptoms.Among these gastrointestinal symptoms,motility disorders are highly prevalent,presenting as chronic constipation,stomach pain,indigestion,diarrhea,and other conditions that severely impact the quality of life of GWI veterans.However,despite a high prevalence of gastrointestinal impairments among these veterans,most research attention has focused on neurological disturbances.This perspective provides a comprehensive overview of current in vivo research advancements elucidating the underlying mechanisms contributing to gastrointestinal disorders in GWI.Generally,these in vivo and in vitro models propose that neuroinflammation alters gut motility and drives the gastrointestinal symptoms reported in GWI.Additionally,this perspective highlights the potential and challenges of in vitro bioengineering models,which could be a crucial contributor to understanding and treating the pathology of gastrointestinal related-GWI. 展开更多
关键词 Gulf War Illness(GWI) Bioengineering Neuroimmune crosstalk Gastrointestinal motility
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Optimization of Talent Cultivation Strategies for Bioengineering Majors under Employment Orientation 认领 引用
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作者 Liqin YIN Yan WAN +2 位作者 Li HAO Yuanmou TANG Yanli XIA 《Agricultural Biotechnology》 2025年第5期77-80,85,共4页
The rapid advancement of the bioeconomy imposes increasingly stringent demands on bioengineering education.Drawing on data from the 2025 Chinese Undergraduate Employment Report and related sources,this study revealed ... The rapid advancement of the bioeconomy imposes increasingly stringent demands on bioengineering education.Drawing on data from the 2025 Chinese Undergraduate Employment Report and related sources,this study revealed that while employment placement rates for bioengineering graduates remain stable,starting salaries exhibit limited growth and career trajectories lack clarity.These challenges originate from a curriculum lagging behind technological progress,inadequate practical training,and a mismatch between student competencies and industry expectations.To address these issues,this paper proposed a strategic framework grounded in"demand-driven design,industry-education integration,and competence-centered development".Key strategies include dynamic curriculum renewal,collaborative university-industry training,holistic competency development,and personalized student support,which collectively aim at enhancing graduates employment competitiveness and long-term professional sustainability. 展开更多
关键词 Bioengineering Biology major Employment orientation Employment quality Talent cultivation Training strategy
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Practical Teaching Reform of Bioengineering for Competency Enhancement : Research on Low-cost and High-efficiency Teaching Mode Based on Video Resources 认领 引用
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作者 Liqin YIN Yan WAN +2 位作者 Li HAO Yuanmou TANG Yanli XIA 《Agricultural Biotechnology》 2025年第6期80-82,87,共3页
Under the background of competency-based transformation of higher education,bioengineering major urgently needs to solve the problems such as the disconnect between practical teaching and industry needs and the lack o... Under the background of competency-based transformation of higher education,bioengineering major urgently needs to solve the problems such as the disconnect between practical teaching and industry needs and the lack of resources.This paper proposed supplementing traditional experimental teaching with video resources to construct a closed-loop model of"theoretical instruction,case analysis,video demonstration,and reflective application".Through the development of instructional videos covering core techniques such as PCR,Western blot,CRISPR-Cas9,cell culture,HPLC,GMP operations,and bioinformatics analysis,teaching costs can be reduced,spatiotemporal constraints can be overcome,and process visualization can be enhanced,thereby supporting students in mastering the entire workflow of modern biomanufacturing.The paper further explored resource development pathways,university-enterprise collaboration mechanisms,and curriculum integration strategies,offering actionable solutions for practical teaching reform. 展开更多
关键词 Bioengineering Practical teaching Competency development Video resources Teaching reform Industry-education integration
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Translational bioengineering strategies for peripheral nerve regeneration:opportunities,challenges,and novel concepts 认领 引用 被引量：12
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作者 Karim A.Sarhane Chenhu Qiu +3 位作者 Thomas G.W.Harris Philip J.Hanwright Hai-Quan Mao Sami H.Tuffaha 《Neural Regeneration Research》 SCIE CAS CSCD 2023年第6期1229-1234,共6页
Peripheral nerve injuries remain a challenging problem in need of better treatment strategies.Despite best efforts at surgical reconstruction and postoperative rehabilitation,patients are often left with persistent,de... Peripheral nerve injuries remain a challenging problem in need of better treatment strategies.Despite best efforts at surgical reconstruction and postoperative rehabilitation,patients are often left with persistent,debilitating motor and sensory deficits.There are currently no therapeutic strategies proven to enhance the regenerative process in humans.A clinical need exists for the development of technologies to promote nerve regeneration and improve functional outcomes.Recent advances in the fields of tissue engineering and nanotechnology have enabled biomaterial scaffolds to modulate the host response to tissue repair through tailored mechanical,chemical,and conductive cues.New bioengineered approaches have enabled targeted,sustained delivery of protein therapeutics with the capacity to unlock the clinical potential of a myriad of neurotrophic growth factors that have demonstrated promise in enhancing regenerative outcomes.As such,further exploration of combinatory strategies leveraging these technological advances may offer a pathway towards clinically translatable solutions to advance the care of patients with peripheral nerve injuries.This review first presents the various emerging bioengineering strategies that can be applied for the management of nerve gap injuries.We cover the rationale and limitations for their use as an alternative to autografts,focusing on the approaches to increase the number of regenerating axons crossing the repair site,and facilitating their growth towards the distal stump.We also discuss the emerging growth factor-based therapeutic strategies designed to improve functional outcomes in a multimodal fashion,by accelerating axonal growth,improving the distal regenerative environment,and preventing end-organs atrophy. 展开更多
关键词 bioengineering biomaterials growth hormone insulin-like growth factor 1 nanotechnology neurobiology peripheral nerve regeneration Schwann cells translational research
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Bioengineering models of female reproduction 认领 引用 被引量：4
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作者 Maria EZubizarreta Shuo Xiao 《Bio-Design and Manufacturing》 SCIE EI CAS CSCD 2020年第3期237-251,共15页
The female reproductive system consists of the ovaries,the female gonads,and the reproductive tract organs of the fallopian tubes,uterus,cervix,and vagina.It functions to provide hormonal support and anatomical struct... The female reproductive system consists of the ovaries,the female gonads,and the reproductive tract organs of the fallopian tubes,uterus,cervix,and vagina.It functions to provide hormonal support and anatomical structure for the production of new offspring.A number of endogenous and exogenous factors can impact female reproductive health and fertility,including genetic vulnerability,medications,environmental exposures,age,nutrition,and diseases.To date,due to the ethical concerns of using human subjects in biomedical research,the majority of studies use in vivo animal models and 2D cellissue culture models to study female reproduction.However,the complexity and species difference of the female reproductive system in humans make it difficult to compare to those of animals.Moreover,the monolayered cells cultured on flat plastics or glass lose their 3D architecture as well as the physical and/or biochemical contacts with other cells in vivo.Further,all reproductive organs do not work alone but interconnect with each other and also with non-reproductive organs to support female reproductive,endocrine,and systemic health.These facts suggest that there is an urgent and unmet need to develop representative,effective,and efficient in vitro models for studying human female reproduction.The prodigious advancements of bioengineering(e.g.,biomaterials,3D printing,and organ-on-a-chip)allow us to study female reproduction in an entirely new way.Here,we review recent advances that use bioengineering methods to study female reproduction,including the bioengineering models of the ovary,fallopian tube,uterus,embryo implantation,placenta,and reproductive disease. 展开更多
关键词 Female reproduction Bioengineering Biomaterials 3D printing Microfluidics
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NucleoCraft:The Art of Stimuli-Responsive Precision in DNA and RNA Bioengineering 认领 引用
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作者 Lu Yu Liangxiao Chen +2 位作者 Deeksha Satyabola Abhay Prasad Hao Yan 《Biomedical Engineering Frontiers》 CAS 2024年第1期132-150,共19页
Recent advancements in DNA and RNA bioengineering have paved the way for developing stimuli-responsive nanostructures with remarkable potential across various applications.These nanostructures,crafted through sophisti... Recent advancements in DNA and RNA bioengineering have paved the way for developing stimuli-responsive nanostructures with remarkable potential across various applications.These nanostructures,crafted through sophisticated bioengineering techniques,can dynamically and precisely respond to both physiological and physical stimuli,including nucleic acids(DNA/RNA),adenosine triphosphate,proteins,ions,small molecules,pH,light,and temperature.They offer high sensitivity and specificity,making them ideal for applications such as biomarker detection,gene therapy,and controlled targeted drug delivery.In this review,we summarize the bioengineering methods used to assemble versatile stimuli-responsive DNA/RNA nanostructures and discuss their emerging applications in structural biology and biomedicine,including biosensing,targeted drug delivery,and therapeutics.Finally,we highlight the challenges and opportunities in the rational design of these intelligent bioengineered nanostructures. 展开更多
关键词 DNA nanostructures biosensing targeted drug delivery bioengineering techniquescan RNA nanostructures physiological physical stimuliincluding bioengineering nucleic acids dna rna adenosine triphosphateproteinsionssmall moleculesphlightand
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The present and the prospect of bioengineering cornea 认领 引用
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作者 Xin Liu Ming-Chang Zhang 《Annals of Eye Science》 2018年第1期52-57,共6页
Corneal blindness represents one of the world’s three major causes of blindness,and the fundamental problem of corneal transplantation is a severe shortage of donor tissues worldwide,resulting in approximately 1.5 mi... Corneal blindness represents one of the world’s three major causes of blindness,and the fundamental problem of corneal transplantation is a severe shortage of donor tissues worldwide,resulting in approximately 1.5 million new cases of blindness annually.To address the growing need for corneal transplants two main approaches are being pursued:allogenic and bioengineering cornea.Bioengineering corneas are constructed by naturally generating an extracellular matrix(ECM)component as the scaffold structure with or without corneal cells.It is well established that the scaffold structure directs the fate of cells,therefore,the fabrication of the correct scaffold structure components could produce an ideal corneal substitute,able to mimic the native corneal function.Another key factor in the construction of tissue engineering cornea is seed cells.However,unlike the epithelium and stroma cells,human cornea endothelium cells(HCECs)are notorious for having a limited proliferative capacity in vivo because of the mitotic block at the G1 phase of the cell cycle due to“contact-inhibition”.This review will focus on the main concepts of recent progress towards the scaffold and seed cells,especially endothelial cells for bioengineering cornea,along with future perspectives. 展开更多
关键词 Bioengineering cornea endothelial cells scaffold
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Bioengineering liver tissue by repopulation of decellularised scaffolds 认领 引用 被引量：1
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作者 Zeeshan Afzal Emmanuel Laurent Huguet 《World Journal of Hepatology》 2023年第2期151-179,共29页
Liver transplantation is the only curative therapy for end stage liver disease,but is limited by the organ shortage,and is associated with the adverse consequences of immunosuppression.Repopulation of decellularised w... Liver transplantation is the only curative therapy for end stage liver disease,but is limited by the organ shortage,and is associated with the adverse consequences of immunosuppression.Repopulation of decellularised whole organ scaffolds with appropriate cells of recipient origin offers a theoretically attractive solution,allowing reliable and timely organ sourcing without the need for immunosuppression.Decellularisation methodologies vary widely but seek to address the conflicting objectives of removing the cellular component of tissues whilst keeping the 3D structure of the extra-cellular matrix intact,as well as retaining the instructive cell fate determining biochemicals contained therein.Liver scaffold recellularisation has progressed from small rodent in vitro studies to large animal in vivo perfusion models,using a wide range of cell types including primary cells,cell lines,foetal stem cells,and induced pluripotent stem cells.Within these models,a limited but measurable degree of physiologically significant hepatocyte function has been reported with demonstrable ammonia metabolism in vivo.Biliary repopulation and function have been restricted by challenges relating to the culture and propagations of cholangiocytes,though advances in organoid culture may help address this.Hepatic vasculature repopulation has enabled sustainable blood perfusion in vivo,but with cell types that would limit clinical applications,and which have not been shown to have the specific functions of liver sinusoidal endothelial cells.Minority cell groups such as Kupffer cells and stellate cells have not been repopulated.Bioengineering by repopulation of decellularised scaffolds has significantly progressed,but there remain significant experimental challenges to be addressed before therapeutic applications may be envisaged. 展开更多
关键词 Regenerative Bioengineering Scaffolds Liver Decellularisation Recellularisation
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Fractional Order Proportional Integral Derivative Controller Design and Simulation for Bioengineering Systems 认领 引用
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作者 Wei-Cheng Fu Chun-Yang Wang +1 位作者 Yao-Wu Shi Ying-Bin Sun 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2013年第5期46-50,共5页
This paper deals with the study of fractional order system tuning method based on Factional Order Proportional Integral Derivative( FOPID) controller in allusion to the nonlinear characteristics and fractional order m... This paper deals with the study of fractional order system tuning method based on Factional Order Proportional Integral Derivative( FOPID) controller in allusion to the nonlinear characteristics and fractional order mathematical model of bioengineering systems. The main contents include the design of FOPID controller and the simulation for bioengineering systems. The simulation results show that the tuning method of fractional order system based on the FOPID controller outperforms the fractional order system based on Fractional Order Proportional Integral( FOPI) controller. As it can enhance control character and improve the robustness of the system. 展开更多
关键词 robustness bioengineering systems fractional order proportional integral derivative controller
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Environmental Cultural Landscape Characteristics of Agricultural Vocational Colleges: A Case Study of Bioengineering Branch of Yangling Vocation and Technical College and Doucun Farm 认领 引用
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作者 CHEN Qi WANG Zhousuo ZHU Zhanbin 《Journal of Landscape Research》 2015年第4期25-28,共4页
Based on the overall planning of environmental cultural construction of Yangling Vocational & Technical College and the college–enterprise co-construction of Doucun Farm, this paper combined environmental cultura... Based on the overall planning of environmental cultural construction of Yangling Vocational & Technical College and the college–enterprise co-construction of Doucun Farm, this paper combined environmental cultural reformation inside and outside the college and reform of off-campus teaching experiment farm in view of outstanding agricultural characteristics of the bioengineering branch, with environmental health preservation as the fundamental goal and "health-preserving agriculture" as the link. In addition, four major characteristic landscape frameworks of "point, line, surface, and body" were established, and the effective construction approaches of health-preserving environmental cultural landscapes in vocational colleges were explored. 展开更多
关键词 Bioengineering Branch Health-preserving agriculture Environmental cultural construction
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Bioengineering Downstream Technology Online Open Course Drives SPOC Hybrid Teaching Reform Based on Ideological and Political Education 认领 引用
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作者 Jiedan Liao 《Journal of Contemporary Educational Research》 2024年第9期17-24,共8页
In the context of emerging engineering disciplines,a hybrid teaching reform for the Bioengineering Downstream Technology course,based on ideological and political education and online open courses,is being carried out... In the context of emerging engineering disciplines,a hybrid teaching reform for the Bioengineering Downstream Technology course,based on ideological and political education and online open courses,is being carried out.This reform focuses on aspects such as“building a professional teacher team for ideological and political education,scientifically designing the ideological and political teaching system,innovating classroom teaching methods,and improving both formative and summative evaluation systems.”The“Craftsmanship in Education and Cultivating Soul and Roots”small private online course hybrid teaching reform for the Bioengineering Downstream Technology online open course provides a replicable model for the comprehensive implementation of ideological and political education in engineering courses and offers a reference for advancing ideological and political education and hybrid teaching reform in new engineering disciplines. 展开更多
关键词 Bioengineering Downstream Technology Ideological and political Online open course Hybrid teaching
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Relevance of Protein Content within the Renal Scaffold for Kidney Bioengineering and Regeneration 认领 引用
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作者 Fatima Guerrero Andres Carmona +4 位作者 Rosa Ortega Sagrario Canadillas Rodolfo Crespo Concha Herrera Pedro Aljama 《Journal of Biomedical Science and Engineering》 2017年第11期509-526,共18页
Chronic kidney disease is currently a major public health problem around the world. Although hemodialysis increases survival of patients with end-stage renal disease, kidney transplantation remains the only potentiall... Chronic kidney disease is currently a major public health problem around the world. Although hemodialysis increases survival of patients with end-stage renal disease, kidney transplantation remains the only potentially curative treatment. However, transplantation as a therapeutic option is limited by availability of suitable donor organs. This situation highlights the urgent need to find new and potentially inexhaustible sources of transplantable organs. Perfusion decellularizarion of whole organs is a novel approach to organ engineering and regeneration. In the present research, we used a continuous perfusion decellularization protocol to eliminate cellular componet of kidney and evaluated residual scaffold components after decellularizarion process by proteomics analysis. Our proteomic data show that this protocol results in incomplete removal of cellular proteins. However, unlike other authors, we assume that proteins retained within decellularized kidney scaffold could be the basis for specific homing and celular differentation in the recellularization process. 展开更多
关键词 Bioengineering Kidney Decellularization Scaffold Proteomic
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Genetic Bioengineering in the Achievement of Algae Biofuels and High-Value Bio-products 认领 引用
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作者 Sukran Cakir Arica 《Management Studies》 2019年第1期60-62,共3页
The dependence to fossil fuels has increased the amount of greenhouse gases in the atmosphere.That is why,the production of renewable and sustainable biofuels has gained a long-term importance for both scientific and ... The dependence to fossil fuels has increased the amount of greenhouse gases in the atmosphere.That is why,the production of renewable and sustainable biofuels has gained a long-term importance for both scientific and political necessities.In this context,algae are promising in terms of alternative biofuels resources.For this reason,intensive scientific researches have been carried out in recent years on providing optimum efficiency in this regard.Bioengineering is a discipline that applies engineering principles of design and analysis to biological systems and biomedical technologies.Examples of bioengineering research include bacteria or microalgae engineered to produce valuable bioactive chemicals.Microalgae by target gene modification may serve as a promising source for the production of biofuels and bio-based chemicals.A lot of research has been carried out by applying microalgae genomic editing technique with the aim to produce numerous biotechnological products.Some successful previously reported research and production activities are still underway in this area.However,in order to produce the desired products efficiently with manipulated microalgae biorefinery,there is a need to overcome the problem of low biomass production despite high production costs.The aim of this work is to give special attention to the rich potential content of microalgae and to provide information on algal genetic manipulations to increase products by bioengineering methods. 展开更多
关键词 algal biofuels algal high-value bio-products bioengineering genetic manipulation microalgae
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Advances in plant natural products:Biosynthesis,bioengineering,and applications 认领 引用
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作者 Alisdair R.Fernie Guoyin Kai Jie Luo 《Journal of Integrative Plant Biology》 SCIE CAS CSCD 2026年第4期845-848,共4页
Plant natural products,the subset of metabolic intermediates made by plants which humans utilize in medicine and industry,are of increasing importance,with some 40%of medicines being plant-derived.While their applicat... Plant natural products,the subset of metabolic intermediates made by plants which humans utilize in medicine and industry,are of increasing importance,with some 40%of medicines being plant-derived.While their applications have been appreciated since antiquity,they are often taxonomically restricted,a fact that has,until recently,posed a major hurdle to understanding their biosynthesis and to their bioengineering. 展开更多
关键词 plant natural products plant natural productsthe biosynthesis metabolic intermediates medicine industry bioengineering applications
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New approaches to increase intestinal length: Methods used for intestinal regeneration and bioengineering 认领 引用
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作者 Ali Shirafkan Mauro Montalbano +2 位作者 Joshua Mc Guire Cristiana Rastellini Luca Cicalese 《World Journal of Transplantation》 2016年第1期1-9,共9页
Inadequate absorptive surface area poses a great challenge to the patients suffering a variety of in-testinal diseases causing short bowel syndrome. To date, these patients are managed with total parenteral nutrition ... Inadequate absorptive surface area poses a great challenge to the patients suffering a variety of in-testinal diseases causing short bowel syndrome. To date, these patients are managed with total parenteral nutrition or intestinal transplantation. However, these carry significant morbidity and mortality. Currently, by emergence of tissue engineering, anticipations to utilize an alternative method to increase the intestinal absorptive surface area are increasing. In this paper, we will review the improvements made over time in attempting elongating the intestine with surgical techniques as well as using intestinal bioengineering. Performing sequential intestinal lengthening was the preliminary method applied in humans. However, these methods did not reach widespread use and has limited outcome. Subsequent experimental methods were developed utilizing scaffolds to regenerate intestinal tissue and organoids unit from the intestinal epithelium. Stem cells also have been studied and applied in all types of tissue engineering. Biomaterials were utilized as a structural support for naive cells to produce bio-engineered tissue that can achieve a near-normal anatomical structure. A promising novel approach is the elongation of the intestine with an acellular biologic scaffold to generate a neoformed intestinal tissue that showed, for the first time, evidence of absorption in vivo. In the large intestine, studies are more focused on regeneration and engineering of sphincters and will be briefly reviewed. From the review of the existing literature, it can be concluded that significant progress has been achieved in these experimental methods but that these now need to be fully translated into a pre-clinical and clinical experimentation to become a future viable therapeutic option. 展开更多
关键词 Bioengineered intestine Tissue engineered Scaffolds Organoids Stem cells Intestinal elongation techniques
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Multifactorial bioengineering in the tendon context to maintain tenocyte phenotype and to direct dermal fibroblasts towards tenogenic lineage 认领 引用
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作者 Adrian Djalali-Cuevas Mandy Rettel +8 位作者 Frank Stein Mikhail Savitski Ioannis Gkiatas Anastasios Korompilias Ioannis Skoufos Athina Tzora Nikitas Prassinos Nikolaos Diakakis Dimitrios I.Zeugolis 《Bioactive Materials》 SCIE CSCD 2026年第2期743-755,共13页
Considering that cells in vivo are simultaneously exposed to multiple signals,multifactorial bioengineering slowly but surely becomes the state of play in controlling cell function in vitro.In this context,herein we a... Considering that cells in vivo are simultaneously exposed to multiple signals,multifactorial bioengineering slowly but surely becomes the state of play in controlling cell function in vitro.In this context,herein we assessed the simultaneous effect of three bioinspired factors(i.e.anisotropic architecture,macromolecular crowding and growth factor supplementation)to maintain human tenocyte phenotype and to direct human dermal fibroblasts towards tenogenic lineage.Anisotropic architecture induced bidirectional cell and deposited extracellular matrix deposition in both cell types.Immunofluorescence analysis revealed that when growth factor and macromolecular crowding were combined significantly increased collagen types I,III,IV and V deposition in both cell types.Proteomics analysis made apparent that the combination of anisotropic architecture,macromolecular crowding and growth factor supplementation brought about the highest degree of tenogenic phenotype maintenance(in the case of human tenocytes)and tenogenic induction(in the case of human dermal fibroblasts).This work lays the foundations for utilising multifactorial bioengineering in the development of tendon-like assemblies. 展开更多
关键词 Multifactorial bioengineering Dermal fibroblasts Tenocytes Cell microenvironment Tendon engineering
Bioengineering extracellular vesicles for enhanced therapeutic functionality and clinical potential in the cardiovascular system 认领 引用
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作者 Yongtao Wang Meiyu Hu +5 位作者 Michail Spanos Shihui Xu Jiaxin Song Guoping Li Dragos Cretoiu Junjie Xiao 《Science Bulletin》 SCIE EI CAS CSCD 2026年第6期1524-1545,共22页
Cardiovascular diseases(CVDs)are a leading cause of morbidity,disability,and mortality worldwide,posing a significant threat to global health.These diseases include myocardial infarction(MI),heart failure(HF),hyperten... Cardiovascular diseases(CVDs)are a leading cause of morbidity,disability,and mortality worldwide,posing a significant threat to global health.These diseases include myocardial infarction(MI),heart failure(HF),hypertension,atherosclerosis(AS),and other pathological cardiac disorders.Despite notable advances in CVD management,such as cardiac-targeted pharmacotherapies,interventional procedures,and heart transplantation,major challenges persist,including adverse drug effects,postoperative complications,and the persistent shortage of heart donors.Extracellular vesicles(EVs)have recently emerged as a promising therapeutic modality owing to their high delivery efficiency,precise targeting potential,and capacity to promote cardiac repair and regeneration.EVs carry a diverse repertoire of bioactive cargos,including proteins,nucleic acids,lipids,and metabolites,facilitating intercellular regulation of immune response,tissue repair,and regenerative processes.Advances in bioengineered EVs also develop the therapeutic potential by enabling the design of vesicles with enhanced targeting specificity and controlled cargo delivery.This review summarizes the complex interactions between EVs and the cardiovascular system,with particular emphasis on their roles in cellular communication,microenvironment modulation,and immune regulation.We further highlight the regenerative capacity of EVs in cardiovascular repair,and discuss emerging clinical applications of native and bioengineered EVs in cardiovascular homeostasis,remodeling,metabolism,and regeneration.These insights pave the way for further exploration of bioengineered EVs as a novel therapeutic platform in cardiovascular medicine. 展开更多
关键词 Extracellular vesicles(EVs) Cardiovascular diseases(CVDs) Targeted drug delivery Myocardial infarction(MI) Heart failure(HF) Bioengineered EVs
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