Lymphoma is one of the most common hematological malignancies(1).In China,an estimated 5,840 new cases and 2,232 deaths were attributable to Hodgkin lymphoma,whereas 108,327 new cases and 39,905 deaths were attributab...Lymphoma is one of the most common hematological malignancies(1).In China,an estimated 5,840 new cases and 2,232 deaths were attributable to Hodgkin lymphoma,whereas 108,327 new cases and 39,905 deaths were attributable to non-Hodgkin lymphoma in 2023(2,3).The Chinese Society of Clinical Oncology(CSCO)first issued its guidelines for the diagnosis and treatment of lymphoma in 2018 and has updated them annually thereafter,incorporating evidence from high-quality clinical studies as well as evolving treatment availability(4).This article summarizes the key updates introduced in the 2026 edition relative to the 2025 edition.展开更多
Colorectal cancer ranks third in incidence worldwide but second in mortality(1).In China,colorectal cancer is the second most common cancer and the most prevalent gastrointestinal malignancy,with both incidence and mo...Colorectal cancer ranks third in incidence worldwide but second in mortality(1).In China,colorectal cancer is the second most common cancer and the most prevalent gastrointestinal malignancy,with both incidence and mortality continuing to rise(2).In 2017,the Chinese Society of Clinical Oncology(CSCO)issued its guidelines for colorectal cancer.These guidelines are updated annually to incorporate the latest clinical research findings,therapeutic agents,and expert opinions(3-8).This article describes the updates made in the 2026 version compared with the 2025 version.展开更多
Colorectal cancer(CRC)is the most frequently diagnosed malignancy of the digestive system and the second leading cause of cancer-related deaths worldwide(1).In China,CRC ranks as the second most common cancer with inc...Colorectal cancer(CRC)is the most frequently diagnosed malignancy of the digestive system and the second leading cause of cancer-related deaths worldwide(1).In China,CRC ranks as the second most common cancer with incidence and mortality rates continuing to rise(2).The Chinese Society of Clinical Oncology(CSCO)first introduced its guidelines in 2017,and since then,they have been updated annually to incorporate the latest clinical research findings,drug availability,and expert consensus(3-8).This article presents the key updates in the 2025 edition compared to the 2024 version.展开更多
The Chinese Society of Clinical Oncology Non-small Cell Lung Cancer(CSCO NSCLC)guidelines were first published in 2016,ranking among the earliest-released guidelines within the CSCO series.In 2020 the CSCO published s...The Chinese Society of Clinical Oncology Non-small Cell Lung Cancer(CSCO NSCLC)guidelines were first published in 2016,ranking among the earliest-released guidelines within the CSCO series.In 2020 the CSCO published separate guidelines for NSCLC and small cell lung cancer(SCLC)for the first time to improve clinical usability.展开更多
In the past year,several advancements have been achieved in the treatment of advanced non-small cell lung cancer(NSCLC),particularly in the areas of immunotherapy and targeted therapy.These achievements have provided ...In the past year,several advancements have been achieved in the treatment of advanced non-small cell lung cancer(NSCLC),particularly in the areas of immunotherapy and targeted therapy.These achievements have provided additional options for improving patient outcomes.The 2024 Chinese Society of Clinical Oncology Guidelines for NSCLC(CSCO NSCLC),a key reference for clinical oncologists in China,have incorporated current global research and adapted recommendations for applicability in real-world scenarios in China.This update covers not only patient selection,efficacy,and safety,but also considers economics,and accessibility,with an aim to provide more precise and comprehensive treatment guidance for Chinese oncologists.展开更多
结直肠癌是目前全球范围内发病率和死亡率较高的恶性肿瘤之一,其诊疗策略随着分子生物学和精准医疗的发展不断更新。本文基于2024年欧洲肿瘤内科学会(European Society for Medical Oncology,ESMO)、美国国立综合癌症网络(National Comp...结直肠癌是目前全球范围内发病率和死亡率较高的恶性肿瘤之一,其诊疗策略随着分子生物学和精准医疗的发展不断更新。本文基于2024年欧洲肿瘤内科学会(European Society for Medical Oncology,ESMO)、美国国立综合癌症网络(National Comprehensive Cancer Network, NCCN)和中国临床肿瘤学会(Chinese Society of Clinical Oncology,CSCO)三大国际权威指南的重要更新,系统对比与解读结直肠癌在分子检测、靶向治疗、免疫治疗、化疗及局部治疗等方面的最新进展。通过对ESMO、NCCN和CSCO结直肠癌诊疗指南进行深入地比较与分析,以期为临床医师提供最新的诊疗参考,推动中国结直肠癌治疗的规范化与精准化发展。展开更多
胃癌是全球范围内高发恶性肿瘤,具有高度侵袭性,总体预后不佳等特点。东西方胃癌人群在流行病学、临床病理学特征、治疗模式及药物选择等方面存在差异。近年来,随着靶向治疗和免疫治疗的快速推进,精准治疗理念的成熟和多学科治疗的推广...胃癌是全球范围内高发恶性肿瘤,具有高度侵袭性,总体预后不佳等特点。东西方胃癌人群在流行病学、临床病理学特征、治疗模式及药物选择等方面存在差异。近年来,随着靶向治疗和免疫治疗的快速推进,精准治疗理念的成熟和多学科治疗的推广等,临床研究成果不断更新,胃癌指南每年持续更新,以适应不断变化的诊疗需求。本文就全球范围内三大权威胃癌指南最新版[包括美国国家综合癌症网络(National Comprehensive Cancer Network,NCCN)胃癌临床实践指南2024年V5版(2024年12月发布)、欧洲肿瘤内科学会(European Society for Medical Oncology,ESMO)胃癌在线指南2024版(2024年9月发布)和中国临床肿瘤协会(Chinese Society of Clinical Oncology,CSCO)胃癌诊疗指南(2024年4月发布)]更新内容的异同点进行对比与梳理,聚焦不可手术切除的局部晚期或转移性食管胃结合部和胃腺癌的临床治疗策略,关注基于靶点如人表皮生长因子受体2(human epidermal growth factor receptor 2,HER2)、程序性死亡受体配体1(programmed death-ligand 1,PDL1)表达、错配修复蛋白(mismatch repair,MMR)状态和新靶点如Claudin18.2(CLDN18.2)等为导向的抗肿瘤药物的精准实施和全程管理。其中,HER2阳性晚期胃癌进入全线抗HER2治疗时代,抗HER2的抗体药物偶联物(antibody-drug conjugate,ADC)成为一线曲妥珠单抗治疗耐药之后的新选择。除此之外,免疫治疗联合化疗成为晚期胃癌一线治疗新标准,基于MMR状态和PD-L1表达指导的诊疗模式将免疫治疗推向精准化,然而目前PD-L1表达检测在临床推广和执行的过程中仍存在一定困难。2024年发表的三大指南融合了最新的临床研究结果、药物适应证的获批情况和医疗保健系统的实情等内容,尤其是CSCO胃癌指南基于中国自主研发药物的快速发展和针对中国人群研究适应证的成功获批进行了更新。三大指南在靶向治疗、免疫疗法等新疗法的推荐和采用等方面存在差异,本文基于不同指南内容展现出不同的视角与侧重,以丰富临床决策的维度,增强循证医学指南的临床适应性,进而指导临床实践。展开更多
目的评估中国临床肿瘤学会(Chinese Society of Clinical Oncology,CSCO)人工智能(artificial intelligence,AI)系统在结直肠癌患者临床决策中的适用性和指南符合率,并探讨其在实际临床应用中的可行性。方法纳入2010年1月至2021年12月...目的评估中国临床肿瘤学会(Chinese Society of Clinical Oncology,CSCO)人工智能(artificial intelligence,AI)系统在结直肠癌患者临床决策中的适用性和指南符合率,并探讨其在实际临床应用中的可行性。方法纳入2010年1月至2021年12月在浙江大学医学院附属第二医院确诊并接受治疗的972例结直肠癌患者。通过CSCO AI系统分析患者数据并生成治疗决策,由盲态独立评审委员会(blinded independent central review,BICR)进行决策符合度评分。统计不同治疗阶段的CSCO AI系统适用率和指南符合率,并采用logistic回归模型分析系统在决策中与实际治疗不符的影响因素。结果CSCO AI系统总适用率为96.2%,总指南符合率为94.9%。在辅助治疗和姑息治疗阶段,系统适用率分别为95.8%和96.7%,指南符合率分别为95.0%和94.9%。多因素logistic回归分析显示,年龄≥65岁和高危Ⅱ期治疗阶段是影响CSCO AI系统在辅助治疗阶段指南符合率的重要因素(均P<0.05)。结论CSCO AI系统在结直肠癌辅助治疗和姑息治疗阶段展示了较高的适用率和指南符合率。该系统的临床决策潜力显著,未来可进一步优化其对特定临床情境的判断,推广其在不同医疗机构中的应用。展开更多
Colorectal cancer(CRC) is one of the major cancers threatening life and health of Chinese residents. According to the latest data released by the National Cancer Center in2015(1), there were 387,000 new cases and 187,...Colorectal cancer(CRC) is one of the major cancers threatening life and health of Chinese residents. According to the latest data released by the National Cancer Center in2015(1), there were 387,000 new cases and 187,100 deaths of CRC in China, accounting for 9.87% and 8.01% of all malignancies. The first version of the Chinese Society of Clinical Oncology(CSCO) guidelines was released in April2017, and has been updated annually based on the latest clinical research data and the availability of new drugs(2-4). Here, we present the main updates of the 2021 version compared to 2020 version.展开更多
Colorectal cancer(CRC)is the second most common cancer and the most common type of gastrointestinal cancer with rapidly increasing incidence and mortality in China(1,2).Since the first edition of the Chinese Society o...Colorectal cancer(CRC)is the second most common cancer and the most common type of gastrointestinal cancer with rapidly increasing incidence and mortality in China(1,2).Since the first edition of the Chinese Society of Clinical Oncology(CSCO)guideline was published in2017,the guideline has been updated annually according to the latest results of clinical research at home and abroad,the accessibility of drugs and the opinions of CSCO experts(3-7).展开更多
2021年4月,中国临床肿瘤学会(Chinese Society of Clinical Oncology,CSCO)乳腺癌专家委员会发布了2021年的CSCO《乳腺癌诊疗指南》。新版指南在2020年指南的基础上,秉承循证医学证据、兼顾诊治方案可及性的原则,对乳腺癌的诊断检查、...2021年4月,中国临床肿瘤学会(Chinese Society of Clinical Oncology,CSCO)乳腺癌专家委员会发布了2021年的CSCO《乳腺癌诊疗指南》。新版指南在2020年指南的基础上,秉承循证医学证据、兼顾诊治方案可及性的原则,对乳腺癌的诊断检查、治疗评估等内容做了推荐调整,同时新增了“靶向药物不良反应管理”、“常态化疫情防控下乳腺癌患者管理”等章节,以期更好地实现患者的全程管理。该文总结新版指南更新要点,并结合最新循证医学进展和药物可及性变化进行了解读。展开更多
According to the latest data released by the National Cancer Center,colorectal cancer(CRC)had the third highest incidence and the fifth highest mortality of all malignancies,with 388,000 new cases and 187,000 cancer d...According to the latest data released by the National Cancer Center,colorectal cancer(CRC)had the third highest incidence and the fifth highest mortality of all malignancies,with 388,000 new cases and 187,000 cancer deaths in China(1).The Chinese Society of Clinical Oncology(CSCO)originally published the English version of 2018 guideline concerning CRC and updated them in2019(2,3).According to the latest progress,clinical guidelines have been updated.Here,we present the main updates of the 2020 version compared to 2019 version.展开更多
According to the latest global cancer statistics,colorectal cancer(CRC)is the most common malignancy of the digestive system and the second most lethal among all cancer types(1).In China,CRC is the second most prevale...According to the latest global cancer statistics,colorectal cancer(CRC)is the most common malignancy of the digestive system and the second most lethal among all cancer types(1).In China,CRC is the second most prevalent cancer,following only after lung cancer(2).The first version of the Chinese Society of Clinical Oncology(CSCO)guideline was launched in 2017 and has been updated annually based on the latest findings of clinical research,drug accessibility and expert consensus(3-8).Here,we present the main updates of the 2024 version compared to the 2023 version.展开更多
In April 2017,the first edition Chinese Society of Clinical Oncology Breast Cancer(CSCO BC)guidelines were released.These guidelines were based on medical evidence,as well as the accessibility and cost effectiveness o...In April 2017,the first edition Chinese Society of Clinical Oncology Breast Cancer(CSCO BC)guidelines were released.These guidelines were based on medical evidence,as well as the accessibility and cost effectiveness of various anticancer drugs in China.The CSCO BC guidelines include regimens with a high level of evidence,good product accessibility and high consistent consensus among Chinese experts as level I recommendations.Regimens with a high level of evidence but poor product accessibility or expert consensus are included as level II recommendations.展开更多
基金supported by the Beijing Research Ward Excellence Program(No.BRWEP2024W032150208)the National Key Research and Development Program of China(No.2023YFF0613403)+1 种基金the Beijing Municipal Administration of Hospitals Incubating Program(No.PX2024038)the Beijing Xisike Clinical Oncology Research Foundation(No.Y-XYN202502-0006)。
摘要Lymphoma is one of the most common hematological malignancies(1).In China,an estimated 5,840 new cases and 2,232 deaths were attributable to Hodgkin lymphoma,whereas 108,327 new cases and 39,905 deaths were attributable to non-Hodgkin lymphoma in 2023(2,3).The Chinese Society of Clinical Oncology(CSCO)first issued its guidelines for the diagnosis and treatment of lymphoma in 2018 and has updated them annually thereafter,incorporating evidence from high-quality clinical studies as well as evolving treatment availability(4).This article summarizes the key updates introduced in the 2026 edition relative to the 2025 edition.
基金supported by the National Natural Science Foundation of China(No.82373415)Zhejiang Provincial Clinical Research Center for Cancer(No.2022E50008,2024ZY01056)Noncommunicable Chronic Diseases-National Science and Technology Major Project(No.2026ZD0552900)。
摘要Colorectal cancer ranks third in incidence worldwide but second in mortality(1).In China,colorectal cancer is the second most common cancer and the most prevalent gastrointestinal malignancy,with both incidence and mortality continuing to rise(2).In 2017,the Chinese Society of Clinical Oncology(CSCO)issued its guidelines for colorectal cancer.These guidelines are updated annually to incorporate the latest clinical research findings,therapeutic agents,and expert opinions(3-8).This article describes the updates made in the 2026 version compared with the 2025 version.
基金supported by the National Natural Science Foundation of China(No.82373415)Beijing Xisike Clinical Oncology Research Foundation(No.Ytongshu2021/ms-0003)。
摘要Colorectal cancer(CRC)is the most frequently diagnosed malignancy of the digestive system and the second leading cause of cancer-related deaths worldwide(1).In China,CRC ranks as the second most common cancer with incidence and mortality rates continuing to rise(2).The Chinese Society of Clinical Oncology(CSCO)first introduced its guidelines in 2017,and since then,they have been updated annually to incorporate the latest clinical research findings,drug availability,and expert consensus(3-8).This article presents the key updates in the 2025 edition compared to the 2024 version.
摘要The Chinese Society of Clinical Oncology Non-small Cell Lung Cancer(CSCO NSCLC)guidelines were first published in 2016,ranking among the earliest-released guidelines within the CSCO series.In 2020 the CSCO published separate guidelines for NSCLC and small cell lung cancer(SCLC)for the first time to improve clinical usability.
基金supported by the Shanghai Excellent Academic Leader(Grant No.21XD1423200)。
摘要In the past year,several advancements have been achieved in the treatment of advanced non-small cell lung cancer(NSCLC),particularly in the areas of immunotherapy and targeted therapy.These achievements have provided additional options for improving patient outcomes.The 2024 Chinese Society of Clinical Oncology Guidelines for NSCLC(CSCO NSCLC),a key reference for clinical oncologists in China,have incorporated current global research and adapted recommendations for applicability in real-world scenarios in China.This update covers not only patient selection,efficacy,and safety,but also considers economics,and accessibility,with an aim to provide more precise and comprehensive treatment guidance for Chinese oncologists.
摘要结直肠癌是目前全球范围内发病率和死亡率较高的恶性肿瘤之一,其诊疗策略随着分子生物学和精准医疗的发展不断更新。本文基于2024年欧洲肿瘤内科学会(European Society for Medical Oncology,ESMO)、美国国立综合癌症网络(National Comprehensive Cancer Network, NCCN)和中国临床肿瘤学会(Chinese Society of Clinical Oncology,CSCO)三大国际权威指南的重要更新,系统对比与解读结直肠癌在分子检测、靶向治疗、免疫治疗、化疗及局部治疗等方面的最新进展。通过对ESMO、NCCN和CSCO结直肠癌诊疗指南进行深入地比较与分析,以期为临床医师提供最新的诊疗参考,推动中国结直肠癌治疗的规范化与精准化发展。
摘要胃癌是全球范围内高发恶性肿瘤,具有高度侵袭性,总体预后不佳等特点。东西方胃癌人群在流行病学、临床病理学特征、治疗模式及药物选择等方面存在差异。近年来,随着靶向治疗和免疫治疗的快速推进,精准治疗理念的成熟和多学科治疗的推广等,临床研究成果不断更新,胃癌指南每年持续更新,以适应不断变化的诊疗需求。本文就全球范围内三大权威胃癌指南最新版[包括美国国家综合癌症网络(National Comprehensive Cancer Network,NCCN)胃癌临床实践指南2024年V5版(2024年12月发布)、欧洲肿瘤内科学会(European Society for Medical Oncology,ESMO)胃癌在线指南2024版(2024年9月发布)和中国临床肿瘤协会(Chinese Society of Clinical Oncology,CSCO)胃癌诊疗指南(2024年4月发布)]更新内容的异同点进行对比与梳理,聚焦不可手术切除的局部晚期或转移性食管胃结合部和胃腺癌的临床治疗策略,关注基于靶点如人表皮生长因子受体2(human epidermal growth factor receptor 2,HER2)、程序性死亡受体配体1(programmed death-ligand 1,PDL1)表达、错配修复蛋白(mismatch repair,MMR)状态和新靶点如Claudin18.2(CLDN18.2)等为导向的抗肿瘤药物的精准实施和全程管理。其中,HER2阳性晚期胃癌进入全线抗HER2治疗时代,抗HER2的抗体药物偶联物(antibody-drug conjugate,ADC)成为一线曲妥珠单抗治疗耐药之后的新选择。除此之外,免疫治疗联合化疗成为晚期胃癌一线治疗新标准,基于MMR状态和PD-L1表达指导的诊疗模式将免疫治疗推向精准化,然而目前PD-L1表达检测在临床推广和执行的过程中仍存在一定困难。2024年发表的三大指南融合了最新的临床研究结果、药物适应证的获批情况和医疗保健系统的实情等内容,尤其是CSCO胃癌指南基于中国自主研发药物的快速发展和针对中国人群研究适应证的成功获批进行了更新。三大指南在靶向治疗、免疫疗法等新疗法的推荐和采用等方面存在差异,本文基于不同指南内容展现出不同的视角与侧重,以丰富临床决策的维度,增强循证医学指南的临床适应性,进而指导临床实践。
摘要目的评估中国临床肿瘤学会(Chinese Society of Clinical Oncology,CSCO)人工智能(artificial intelligence,AI)系统在结直肠癌患者临床决策中的适用性和指南符合率,并探讨其在实际临床应用中的可行性。方法纳入2010年1月至2021年12月在浙江大学医学院附属第二医院确诊并接受治疗的972例结直肠癌患者。通过CSCO AI系统分析患者数据并生成治疗决策,由盲态独立评审委员会(blinded independent central review,BICR)进行决策符合度评分。统计不同治疗阶段的CSCO AI系统适用率和指南符合率,并采用logistic回归模型分析系统在决策中与实际治疗不符的影响因素。结果CSCO AI系统总适用率为96.2%,总指南符合率为94.9%。在辅助治疗和姑息治疗阶段,系统适用率分别为95.8%和96.7%,指南符合率分别为95.0%和94.9%。多因素logistic回归分析显示,年龄≥65岁和高危Ⅱ期治疗阶段是影响CSCO AI系统在辅助治疗阶段指南符合率的重要因素(均P<0.05)。结论CSCO AI系统在结直肠癌辅助治疗和姑息治疗阶段展示了较高的适用率和指南符合率。该系统的临床决策潜力显著,未来可进一步优化其对特定临床情境的判断,推广其在不同医疗机构中的应用。
基金supported by the National Key R&D Program of China (No. 2018YFC1312100)the National Natural Science Foundation of China (No. 81872481)Traditional Chinese Medicine (Integrated Chinese and Western Medicine) Key Discipline Construction Project of Zhejiang Province (No. 2017-XK-A40)。
摘要Colorectal cancer(CRC) is one of the major cancers threatening life and health of Chinese residents. According to the latest data released by the National Cancer Center in2015(1), there were 387,000 new cases and 187,100 deaths of CRC in China, accounting for 9.87% and 8.01% of all malignancies. The first version of the Chinese Society of Clinical Oncology(CSCO) guidelines was released in April2017, and has been updated annually based on the latest clinical research data and the availability of new drugs(2-4). Here, we present the main updates of the 2021 version compared to 2020 version.
基金supported by the Provincial Key R&D Program of Zhejiang Province(No.2021C03125)Beijing Xisike Clinical Oncology Research Foundation(No.Y-tongshu2021/ms-0003)。
摘要Colorectal cancer(CRC)is the second most common cancer and the most common type of gastrointestinal cancer with rapidly increasing incidence and mortality in China(1,2).Since the first edition of the Chinese Society of Clinical Oncology(CSCO)guideline was published in2017,the guideline has been updated annually according to the latest results of clinical research at home and abroad,the accessibility of drugs and the opinions of CSCO experts(3-7).
摘要2021年4月,中国临床肿瘤学会(Chinese Society of Clinical Oncology,CSCO)乳腺癌专家委员会发布了2021年的CSCO《乳腺癌诊疗指南》。新版指南在2020年指南的基础上,秉承循证医学证据、兼顾诊治方案可及性的原则,对乳腺癌的诊断检查、治疗评估等内容做了推荐调整,同时新增了“靶向药物不良反应管理”、“常态化疫情防控下乳腺癌患者管理”等章节,以期更好地实现患者的全程管理。该文总结新版指南更新要点,并结合最新循证医学进展和药物可及性变化进行了解读。
摘要According to the latest data released by the National Cancer Center,colorectal cancer(CRC)had the third highest incidence and the fifth highest mortality of all malignancies,with 388,000 new cases and 187,000 cancer deaths in China(1).The Chinese Society of Clinical Oncology(CSCO)originally published the English version of 2018 guideline concerning CRC and updated them in2019(2,3).According to the latest progress,clinical guidelines have been updated.Here,we present the main updates of the 2020 version compared to 2019 version.
基金supported by the Provincial Key R&D Program of Zhejiang Province(No.2021C03125)National Natural Science Foundation of China(No.82373415 and No.82302489)Beijing Xisike Clinical Oncology Research Foundation(No.Y-tongshu2021/ms-0003).
摘要According to the latest global cancer statistics,colorectal cancer(CRC)is the most common malignancy of the digestive system and the second most lethal among all cancer types(1).In China,CRC is the second most prevalent cancer,following only after lung cancer(2).The first version of the Chinese Society of Clinical Oncology(CSCO)guideline was launched in 2017 and has been updated annually based on the latest findings of clinical research,drug accessibility and expert consensus(3-8).Here,we present the main updates of the 2024 version compared to the 2023 version.
基金This work was supported by the Capital Clinical Characteristic Application Research(Grant No.Z181100001718215)the innovative projects of PLA General Hospital(Grant No.CX19011).
摘要In April 2017,the first edition Chinese Society of Clinical Oncology Breast Cancer(CSCO BC)guidelines were released.These guidelines were based on medical evidence,as well as the accessibility and cost effectiveness of various anticancer drugs in China.The CSCO BC guidelines include regimens with a high level of evidence,good product accessibility and high consistent consensus among Chinese experts as level I recommendations.Regimens with a high level of evidence but poor product accessibility or expert consensus are included as level II recommendations.