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Clinical study of repetitive transcranial magnetic stimulation in the rehabilitation of post-stroke depression:A Quantitative Insomnia Sleep Inventory monitoring evaluation 认领 引用
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作者 Ai-Ming Gu Chao Liu +3 位作者 Jian-Hong Chen Ru-Ya Guo Chao Liang Xing-Shi Chen 《World Journal of Psychiatry》 SCIE 2026年第3期110-117,共8页
BACKGROUND Jiaxing Hospital of Traditional Chinese Medicine introduced transcranial magnetic stimulation(TMS)technology in 2019.In practical application,it was found that different types of equipment and technical par... BACKGROUND Jiaxing Hospital of Traditional Chinese Medicine introduced transcranial magnetic stimulation(TMS)technology in 2019.In practical application,it was found that different types of equipment and technical parameters could lead to differences in therapeutic effects.Therefore,our hospital selected a Danish-made TMS device,which ranked second in the Chinese market,and conducted tests on Gu AM et al.rTMS for PSD rehab http://gffzz4205af39ffde493esx0vpufqwv0ub6fkv.ffgz.tsg.suse.edu.cn/10.5498/wjp.v16.i3.1160942 March 19,2026 Volume 16 Issue 3 patients with post-stroke depression(PSD)from March 2019 to September 2023.Before the test,a plan was formulated based on the quality status before and after the inspection.Two evaluators independently controlled the quality of the plan.The repetitive TMS(rTMS)and Quantitative Insomnia Sleep Inventory(QUISI)data were separately stored and verified independently by the two evaluators.AIM To investigate the effect of rTMS and QUISI on the sleep and rehabilitation of patients with PSD.METHODS From March 2019 to December 2023,subjects who were admitted to the Department of Rehabilitation of the Jiaxing Hospital of Traditional Chinese Medicine,Shanghai Mental Health Center,and National Medical Centre for Psychiatric Disorders were enrolled.A total of 108 patients with PSD were enrolled:54 patients in the observation group and 54 in the control group.Sixty-eight normal volunteers were also included.Both the observation group and the control group received venlafaxine 150 mg/day sustained-release therapy.The observation group was given venlafaxine combined with rTMS.The control group was treated with venlafaxine combined with rTMS pseudo stimulation.The two groups underwent 42 treatment sessions over 14 weeks.The Hamilton Depression Rating Scale-17 scores were compared between the two groups before and after treatment,and the changes in QUISI were compared with healthy volunteers.RESULTS The Hamilton Depression Rating Scale-17 scores in the two groups were significantly reduced after treatment,and the improvement was more significant in the observation group(P<0.05).Before treatment,the sleep latency in the two groups of patients by QUISI was delayed compared to normal volunteers,and the sleep efficiency and maintenance rate were lower than those in normal volunteers,with statistical significance(P<0.05-0.01).After 14 weeks of treatment,the sleep latency period in the observation group QUISI shifted forward,indicating an increase in sleep efficiency and maintenance rate.The differences between the observation group and the control group were statistically significant(P<0.01).After a 3-month rehabilitation evaluation,the total effective rate of patients in the observation group was significantly higher than that in the control group(P<0.05).CONCLUSION rTMS treatment has a positive effect on PSD in clinical practice.QUISI monitoring can be used for rehabilitation assessment. 展开更多
关键词 Post-stroke depression Repetitive transcranial magnetic stimulation Quantitative Insomnia Sleep Inventory monitoring Evaluation of rehabilitation Clinical study
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Methodological challenges and recommendations for acupuncture clinical study:A scoping review 认领 引用 被引量：2
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作者 Xiang-yu HU Wen-cui XIU +7 位作者 Zi-yu TIAN Rui-min JIAO Huan CHEN Xiao-yi HU Lan-jun SHI Tian-yu MING Wei-juan GANG Xiang-hong JING 《World Journal of Acupuncture-Moxibustion》 CAS CSCD 2025年第1期1-9,共9页
Background:Methodological issues and challenges hinder the high-quality development of acupuncture clinical studies.Objective:To systematically summarize the methodological issues,challenges,and recommendations in acu... Background:Methodological issues and challenges hinder the high-quality development of acupuncture clinical studies.Objective:To systematically summarize the methodological issues,challenges,and recommendations in acupuncture clinical research using the participant,intervention,comparison,outcome,and study design(PICOS)framework to generate a comprehensive list of methodological questions and recommendations.Methods:We searched seven databases for articles on the methodological aspects of clinical acupuncture research from their inception to March 24,2023.Two researchers independently screened the titles,ab-stracts,and full text of each article.Data extraction and analyses were performed for the eligible studies.Finally,the methodological challenges and recommendations for acupuncture clinical studies are listed,and the frequency of methodological challenges is displayed in a sunburst chart.Results:A total of 226 studies were included in the review,most of which originated in China(173,77%),followed by the United States(25,11%)and the United Kingdom(12,5%).Clinical research on acupuncture faces methodological challenges that span the five elements of the PICOS framework.The most frequently mentioned issues were related to comparison,followed by study design and interven-tions.If further categorized,the establishment of the control group is undoubtedly the most concerning issue for researchers.Conclusion:This review provides a comprehensive overview of the challenges and recommendations for each aspect of the PICOS framework in clinical acupuncture research. 展开更多
关键词 Acupuncture Clinical study Methodological challenge Scoping review
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Phase I clinical study of humanized BCMA-single-domain antibodies targeting CAR-T in patients with relapsed or refractory multiple myeloma 认领 引用
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作者 Gaofeng Zheng Ruyi Xu +6 位作者 Heng Mei Xiaoyan Han Donghua He Yanling Weng Cheng Wen Zhuoxiao Cao Zhen Cai 《Cancer Biology & Medicine》 SCIE CAS CSCD 2025年第11期1377-1380,共4页
Multiple myeloma(MM),one of the most common hemato logical neoplasms worldwide,originates from malignant plasma cells in the bone marrow.MM remains an incurable disease,although continued treatment advancements have m... Multiple myeloma(MM),one of the most common hemato logical neoplasms worldwide,originates from malignant plasma cells in the bone marrow.MM remains an incurable disease,although continued treatment advancements have markedly increased overall survival.Many patients with MM eventually experience relapse or become treatment-refractory1.Patients with relapsed or refractory multiple myeloma(RRMM)become progressively more challenging to manage and have poor prognosis2. 展开更多
关键词 CAR T relapsed refractory multiple myeloma bone marrowmm phase I clinical study hemato logical neoplasms multiple myeloma rrmm become malignant plasma cells multiple myeloma mm one
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Ganoderma lucidum:a comprehensive review of phytochemistry,efficacy,safety and clinical study 认领 引用 被引量：17
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作者 Sijia Wu Siyuan Zhang +5 位作者 Bo Peng Dechao Tan Mingyue Wu Jinchao Wei Yitao Wang Hua Luo 《Food Science and Human Wellness》 SCIE CAS CSCD 2024年第2期568-596,共29页
Ganoderma lucidum,one of the most well-known edible fungi,is believed to be very beneficial for longevity and vitality.A long usage history suggests that G.lucidum has various clinical therapeutic effects.And experime... Ganoderma lucidum,one of the most well-known edible fungi,is believed to be very beneficial for longevity and vitality.A long usage history suggests that G.lucidum has various clinical therapeutic effects.And experimental studies have confirmed that G.lucidum has multiple pharmacological effects,including antitumor,anti-microbial,anti-HIV protease,and antidiabetic activity and so on.With the deepening of research,more than 300 compounds have been isolated from G.lucidum.There is an increasing population of G.lucidum-based products,and its international development is expanding.Currently,G.lucidum has drawn much attention to its chemical composition,therapeutic effect,clinical value,and safety.This paper provides a comprehensive review of these aspects to enhance the global promotion of G.lucidum. 展开更多
关键词 Ganoderma lucidum Phytochemistry Efficacy Safety Clinical study
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Clinical study on the treatment of liver fibrosis due to hepatitis B by IFN-α1 and traditional medicine preparation 认领 引用 被引量：30
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作者 CHENG Ming-Liang WU Ya-Yun +4 位作者 HUANG Ke-Fu LUO Tian-Yong DING Yi-Shen LU Yin-Yin LIU RenCaiand Wu Jun 《World Journal of Gastroenterology》 SCIE CAS 1999年第3期267-269,共3页
关键词 Clinical study on the treatment of liver fibrosis due to hepatitis B by IFN West and traditional medicine preparation
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Effect of Jianpi Shengxue Tablet on Iron Metabolism and Nutritional Status in Patients with Renal Anemia:A Prospective,Randomized,Open,Parallel Controlled and Multicenter Clinical Study 认领 引用 被引量：3
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作者 Juan YANG Meng-yuan LIANG +15 位作者 Yu LI Hao ZHANG Wei LI Jing LV Li-ping DONG Jing-song JIN Cheng YANG Qing-hong ZHANG Li LONG Rong ZOU Yi GAO Dan SONG Chun-qin PAN Ying YAO Xiao-lin ZHAN Xiao-hui WANG 《Current Medical Science》 SCIE CAS 2024年第3期603-610,共8页
Objective This study aimed to analyze the clinical efficacy of the Jianpi Shengxue tablet for treating renal anemia.Methods A total of 200 patients with renal anemia from December 2020 to December 2022 were enrolled a... Objective This study aimed to analyze the clinical efficacy of the Jianpi Shengxue tablet for treating renal anemia.Methods A total of 200 patients with renal anemia from December 2020 to December 2022 were enrolled and randomly divided into two groups.Patients in the control group were treated with polysaccharide-iron complex,and those in the experimental group were administered Jianpi Shengxue tablet.After 8 weeks of continuous treatment,the therapeutic outcomes regarding anemia were compared between the two groups.Results After treatment,the red blood cell(RBC)count,hematocrit(HCT),reticulocyte percentage(RET),ferritin(SF),serum iron(SI),transferrin saturation(TSAT),and serum albumin(ALB)all increased(P<0.01),and the clinical symptom score and total iron binding capacity decreased(P<0.01)in the experimental group.Moreover,the improvements in RBC,HCT,RET,SF,SI,TAST,ALB,and clinical symptoms(fatigue,anorexia,dull skin complexion,numbness of hands and feet)in the experimental group were significantly greater than those in the control group(P<0.05).The total effective rate for treating renal anemia was significantly higher in the experimental group than in the control group(P<0.01).Conclusion The Jianpi Shengxue tablet demonstrates efficacy in treating renal anemia,leading to significant improvements in the laboratory examination results and clinical symptoms of patients with renal anemia. 展开更多
关键词 Jianpi Shengxue tablet renal anemia randomized open parallel control multicenter clinical study
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A clinical study of Weining Granules in the treatment of gastric precancerous lesions 认领 引用 被引量：15
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作者 邓鑫 刘振威 +2 位作者 吴发胜 李龙华 梁健 《Journal of Traditional Chinese Medicine》 SCIE CSCD 2012年第2期164-172,共9页
OBJECTIVE:To investigate the clinical effects of Weining Granules on gastric precancerous lesions(GPLs).METHODS:120 patients with GPLs were randomly assigned in a 1:1 ratio to receive Weining Granules(trial group) or ... OBJECTIVE:To investigate the clinical effects of Weining Granules on gastric precancerous lesions(GPLs).METHODS:120 patients with GPLs were randomly assigned in a 1:1 ratio to receive Weining Granules(trial group) or the comparator Weifuchun tablets(control group) for 6 months.Outcomes were compared between the two groups including:overall response;gastroscopically-determined response;pathologically-confirmed response;eradication of Helicobacter pylori(HP);microvessel density(MVD) in the gastric mucosa;expression of vascular endothelial growth factor(VEGF);interleukin 2(IL-2);interleukin 6(IL-6);T lymphocyte subsets;immunoglobulins;symptom scores;quality of life(QOL);and adverse reactions.RESULTS:Patients in the trial group had a significantly higher(P<0.05) overall response rate(81.7%) as compared with those in the control group(63.3%).Relative to treatment with Weifuchun tablets treatment with Weining Granules resulted in a significant improvement(P<0.05) in the scores for gastric pain,distension and stuffiness in the hypochondrium,and anorexia.As compared with the tablets the Granules were associated with a significantly higher overall gastroscopically-determined response rate(78.3%;P<0.05).Pathological examination of tissue samples indicated that 61.7% of patients receiving the granules were cured with an overall response rate of 75.5%;these rates were significantly higher than in the control group(P<0.05).In comparison with patients receiving the tablets,those given the granules were significantly more likely to have their HP eradicated(75.0% vs.51.4%;P<0.05).Improvements in MVD,VEGF,CD4+,CD4+/CD8+,IL-2,IL-6 and IgG were significantly greater with the Weining Granules than with the Weifuchun tablets(P<0.05 or P<0.01).After follow-up of 1 year,17.5% of patients in the trial group relapsed as compared with 39.5% in the control group(P<0.05).Relative to the control group,the trial group showed significantly greater improvements in physical,psychological and social relationships,and in environmental domains(P<0.05 or P<0.01).No significant adverse reactions were observed during treatment.CONCLUSION:The Weining Granules appear to be effective in improving the gastric precancerous state and the main symptoms,in inhibiting angiogenesis,enhancing immune function and QOL,and in reducing 1-year relapses.In addition,this preparation seems to be associated with a low risk of adverse events,making it a safe and efficacious option for the treatment of GPLs. 展开更多
关键词 Gastric precancerous lesions Weining Granules Weifuchun Tablets Clinical study
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Chemotherapy of cerebral gliomas directed by the chemosensitivity test in vitro: a clinical study 认领 引用 被引量：2
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作者 Chaochun Yu Fanmin Zhou +4 位作者 Yuqian Wang Ping Zhong Guanfu Jiang Aichi Miao Hao Lu 《The Chinese-German Journal of Clinical Oncology》 2007年第3期269-273,共5页
Objective： To evaluate correlation between chemosensitivity of tumor cells in vitro and their clinical responsiveness in vivo by comparing the difference of curative effect between chemotherapy of cerebral gliomas di... Objective： To evaluate correlation between chemosensitivity of tumor cells in vitro and their clinical responsiveness in vivo by comparing the difference of curative effect between chemotherapy of cerebral gliomas directed by chemosensitivity test in vitro and its routine chemotherapy. Methods： Sixty-two patients with cerebral gliomas were recruited as the experiment group, who had received total resection or subtotal resection of the tumor. The resected tumor cells were cultured in vitro, followed by chemosensitivity test using colorimetric MTT assay. Finally, chemotherapeutic protocol was made based on the results of the chemosensitivity test. Fifty patients with cerebral gliomas subjected to the routine chemotherapeutic protocol were simultaneously recruited as the control group, whose age, gender, survival functional status and operational fashion were matched with the experiment group. The two groups were equally followed up for the survival functional status, recurrence and death. All data were analyzed using SPSS 10.0 software. Results： At the time of evaluation, KPS values of 64.52 ± 35.84 were seen in the experiment group, and 33.60 ± 36.24 in the control group, showing statistical difference between the two groups （t = 4.5163, P = 0.000）. During 2-4 years of follow up, a recurrence rate of 32.26% was seen in the experimental group, and 60.00% in the control group, showing a statistical difference between the two groups （X^2 = 8.620, P = 0.003）. The fatality was 22.58% in the experiment group, and 48.00% in the control group, showing a statistical difference between the two groups （X^2 = 7.978, P = 0.005）. The survival rate of the experimental group was higher than that of the control group, showing a statistical differences between the two groups （X^2= 7.29, P = 0.0069）. Conclusion： Chemotherapy of glio- mas under the guidance of chemosensitivity test in vitro contributes to obvious improvement on the current survival functional status, a clear decline of the recurrence rates and fatality rate, and raised survival rates of the patients. A close correlation between the chemosensitivity in vitro and clinical responsiveness in vivo is observed. 展开更多
关键词 gliomas chemotherapy chemosensitivity clinical study
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Clinical Study of Dahuang Zhechong Pill (大黄■虫丸) in Treating Posthepatitis B Hepatic Fibrosis 认领 引用 被引量：2
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作者 陈孝银 李恩庆 +4 位作者 杨钦河 章群 孙立 徐云生 沈强 《Chinese Journal of Integrated Traditional and Western Medicine》 2004年第1期63-65,共3页
Hepatic fibrosis is the only way for all kinds of chronic hepatic diseases to develop into liver cirrhosis. How to block and reverse hepatic fibrosis is the key issue for treatment of all kinds of chronic hepatic dise... Hepatic fibrosis is the only way for all kinds of chronic hepatic diseases to develop into liver cirrhosis. How to block and reverse hepatic fibrosis is the key issue for treatment of all kinds of chronic hepatic disease. After many years’ arduous effort in treating hepatic fibrosis, no satisfactory results in western medical treatment have been obtained. Though hepatic fibrosis could be definitely re- 展开更多
关键词 TCM in Treating Posthepatitis B Hepatic Fibrosis Clinical Study of Dahuang Zhechong Pill
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Clinical Study on Effect of Xiaoyao Nose Drops (逍遥滴鼻液) in Stopping Episode of Migraine 认领 引用 被引量：1
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作者 胡怀强 周永红 王新陆 《Chinese Journal of Integrated Traditional and Western Medicine》 2006年第2期112-117,共6页
Objective： To observe the effect of Xiaoyao Nose Drops （逍遥滴鼻液 , XYND） in stopping episode of migraine. Methods： Adopted was the randomized double-blinded placebo-controled method, with the 126 patients equall... Objective： To observe the effect of Xiaoyao Nose Drops （逍遥滴鼻液 , XYND） in stopping episode of migraine. Methods： Adopted was the randomized double-blinded placebo-controled method, with the 126 patients equally assigned to two groups, the treated group treated with XYND and the control group with placebo, and the therapeutic course was 30 days for all. The clinical total effective rate and effect in al- leviating headache were observed. And hemorrheological parameters as well as the blood flow of the anterior cerebral artery （ACA）, median cerebral artery （MCA） and posterior cerebral artery （PCA） were measured before and after treatment. Results： The clinical total effective rate and headache alleviating rate in the treated group were 93.33% and 96.67% respectively, while those in the control group were 18.33% and 20.00 % respectively, and comparison between the two groups showed significant difference （all P〈0.01）. The blood viscosity （high, middle and low shear）, plasma viscosity and fibrinogen got lowered significantly in the treated group after treatment, showing significant difference in comparison either with those before treatment or with those in the control group after treatment （P〈0.05 or P〈0.01）. The velocity of blood flow in all cerebral arteries lowered significantly, also showing significant difference in comparison either with those before treatment or with those in the control group after treatment （ P 〈 0.05 or P 〈 0.01 ）. Conclusion： XYND is effective in stopping the headache of patients with migraine, and worth applying in clinical practice. 展开更多
关键词 Xiaoyao Nose Drops migraine transnasal medication clinical study
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Clinical Study on Effect of Shenmai Injection in Treating Congestive Heart Failure 认领 引用 被引量：1
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作者 龙明智 王迪斌 +1 位作者 杨季明 周丽英 《Chinese Journal of Integrated Traditional and Western Medicine》 2004年第1期62-62,共1页
Objective: To observe the therapeutic effect of Shenmai Injection (SI) in treating congestive heart failure (CHF). Methods: The changes in cAMP, cGMP, serum cardiac troponin T (cTnT, a specific marker reflecting myoca... Objective: To observe the therapeutic effect of Shenmai Injection (SI) in treating congestive heart failure (CHF). Methods: The changes in cAMP, cGMP, serum cardiac troponin T (cTnT, a specific marker reflecting myocardial injury), creatine kinase (CK) and creatine kinase isoenzyme (CK- 展开更多
关键词 CHF Clinical Study on Effect of Shenmai Injection in Treating Congestive Heart Failure
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Objective electrophysiological contrast sensitivity with monofocal and multifocal intraocular lenses:a prospective clinical study 认领 引用
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作者 Salvatore Cillino Giovanni Cillino +4 位作者 Simona Di Naro Aissa Iggui Viviana Firpo Girolamo Maniscalco Alessandra Casuccio 《Annals of Eye Science》 2018年第1期136-146,共11页
Background:To compare objective electrophysiological contrast sensitivity function(CSF)in patients implanted with either multifocal intraocular lenses(MIOLs)or monofocal intraocular lenses(IOLs)by pattern reversal vis... Background:To compare objective electrophysiological contrast sensitivity function(CSF)in patients implanted with either multifocal intraocular lenses(MIOLs)or monofocal intraocular lenses(IOLs)by pattern reversal visual evoked potentials(prVEP)measurements.Methods:Fourty-five cataract patients were randomly allocated to receive bilaterally:apodized diffractive-refractive Alcon Acrysof MIOL(A),full diffractive AMO Tecnis MIOL(B)or monofocal Alcon Acrysof IOL(C).Primary outcomes:1-year differences in objective binocular CSF measured by prVEP with sinusoid grating stimuli of 6 decreasing contrast levels at 6 spatial frequencies.Secondary outcomes:psychophysical CSF measured with VCTS-6500,photopic uncorrected distance(UDVA),and mesopic and photopic uncorrected near and intermediate visual acuities(UNVA and UIVA respectively).Results:Electrophysiological CSF curve had an inverted U-shaped morphology in all groups,with a biphasic pattern in Group B.Group A showed a lower CSF than group B at 4 and 8 cpd,and a lower value than group C at 8 cpd.Psychophysical CSF in group A exhibited a lower value at 12 cpd than group B.Mean photopic and mesopic UNVA and UIVA were worse in monofocal group compared to the multifocal groups.Mesopic UNVA and UIVA were better in group B.Conclusions:Electrophysiological CSF behaves differently depending on the types of multifocal or monofocal IOLs.This may be related to the visual acuity under certain conditions or to IOL characteristics.This objective method might be a potential new tool to investigate on MIOL differences and on subjective device-related quality of vision. 展开更多
关键词 Electrophysiological contrast sensitivity visual evoked potentials(VEPs) multifocal intraocular lens(MIOLs) prospective clinical study
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Clinical study of ultrasound and microbubbles for enhancing chemotherapeutic sensitivity of malignant tumors in digestive system 认领 引用 被引量：10
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作者 Yanjie Wang Yan Li +4 位作者 Kun Yan Lin Shen Wei Yang Jifang Gong Ke Ding 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2018年第5期553-563,共11页
Objective： To explore the safety of ultrasound and microbubbles for enhancing the chemotherapeutic sensitivity of malignant tumors in the digestive system in a clinical trial, as well as its efficacy.Methods： From O... Objective： To explore the safety of ultrasound and microbubbles for enhancing the chemotherapeutic sensitivity of malignant tumors in the digestive system in a clinical trial, as well as its efficacy.Methods： From October 2014 to June 2016, twelve patients volunteered to participate in this study. Eleven patients had hepatic metastases from tumors of the digestive system, and one patient had pancreatic carcinoma. According to the mechanical index （MI） in the ultrasound field, patients were classified into four groups with MIs of 0.4, 0.6, 0.8 and 1.0. Within half an hour after chemotherapy, patients underwent ultrasound scanning with ultrasound microbubbles （SonoVue） to enhance the efficacy of chemotherapy. All adverse reactions were recorded and were classified in 4 grades according to the Common Terminology Criteria for Adverse Events version 4.03 （CTCAE V4.03）. Tumor responses were evaluated by the Response Evaluation Criteria in Solid Tumors version 1.1 criteria. All the patients were followed up until progression.Results： All the adverse reactions recorded were level 1 or level 2. No local pain occurred in any of the patients. Among all the adverse reactions, fever might be related to the treatment with ultrasound combined with microbubbles. Six patients had stable disease （SD）, and one patient had a partial response （PR） after the first cycle of treatment. At the end of follow-up, tumor progression was restricted to the original sites, and no new lesions had appeared.Conclusions： Our preliminary data showed the potential role of a combined treatment with ultrasound and microbubbles in enhancing the chemotherapeutic sensitivity of malignant tumors of the digestive system. This technique is safe when the MI is no greater than 1.0. 展开更多
关键词 Clinical study sonoporation microbubbles chemotherapy digestive system
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Clinical Study on Effect of Yuantong Capsule in Treating Vascular Dementia 认领 引用
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作者 黄俊山 林求诚 +2 位作者 黄荣璋 郑关毅 林智颖 《Chinese Journal of Integrated Traditional and Western Medicine》 2004年第1期77-77,共1页
Objective: To observe the clinical effect of Yuantong Capsule (YTC) in treating vascular dementia (VD). Methods: Eighty-three patients of VD were randomized on ratio of 2 : 1 into two groups, the 54 patients in the tr... Objective: To observe the clinical effect of Yuantong Capsule (YTC) in treating vascular dementia (VD). Methods: Eighty-three patients of VD were randomized on ratio of 2 : 1 into two groups, the 54 patients in the treated group were treated with YTC orally administered, 3 times a 展开更多
关键词 Clinical Study on Effect of Yuantong Capsule in Treating Vascular Dementia
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CLINICAL STUDY ON SERUM COPPER AND ZINC LEVELS AND COPPER/ZINC RATIO IN MALIGNANT LYMPHOMA 认领 引用
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作者 吴海鹰 俞鲁谊 《Chinese Journal of Cancer Research》 CAS 1989年第3期53-56,共4页
173 simultaneous determinations of serum copper levels (SCL), serum zinc levels (SZL) and copper/zinc ratio (CZR) were made by atomic absorption spectrophotometry in 51 previously untreated lymphoma patients. SCL and ... 173 simultaneous determinations of serum copper levels (SCL), serum zinc levels (SZL) and copper/zinc ratio (CZR) were made by atomic absorption spectrophotometry in 51 previously untreated lymphoma patients. SCL and CZR were significantly higher in patients before treatment (mean value 22.97 μmol/L, 1.55, respectively) and in those who did not reach complete remission (mean 21.21 μmol/L, 1.36) as compared with the patients in complete remission (mean 16.36 μmol/L, 1.06) or normal controls (mean 15.67 μmol/L, 0.98). The mean value of SCL and CZR of patients in complete remission did not differ significantly from those of normal controls. Patients in stages HI and IV had higher SCL and CZR (mean 25.15 μmol/L, 1.79) than those in stage Ⅰ and Ⅱ (mean 19.30 μmol/L, 1.16). No significant difference in SZL was observed between the patient groups and normal controls. Thus, SCL and CZR may be used as prognostic indicators for monitoring disease activity and response to therapy in malignant lymphoma. 展开更多
关键词 SCL CLINICAL STUDY ON SERUM COPPER AND ZINC LEVELS AND COPPER/ZINC RATIO IN MALIGNANT LYMPHOMA NHL
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Clinical Study of Vitamin K_3 Acupoint Injection In Treating Pelvic Pain 认领 引用
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作者 赵文洁 王莉 +1 位作者 翁健儿 俞瑾 《Chinese Journal of Integrated Traditional and Western Medicine》 2003年第2期136-138,共3页
Pelvic pain is one of the most common symptoms in gynecologic outpatients. Primary dysmenorrhea, acute or chronic pelvic inflammatory disease, endometriosis, post-operational pelvic adhesion, blood stagnation of pelvi... Pelvic pain is one of the most common symptoms in gynecologic outpatients. Primary dysmenorrhea, acute or chronic pelvic inflammatory disease, endometriosis, post-operational pelvic adhesion, blood stagnation of pelvic vein, etc. , are mentioned as the often encountered causes of pelvic pain. It has been reported in the recent ten or more years that intramuscular injection of vitamin K3 (Vit K3) could relieve pain induced by smooth muscle spasm. In order to evaluate the effect of Vit K3 administered by acupoint injection in relieving pelvic pain, 180 patients were treated and observed from April 1997 to April 1999 in our hospital, and good therapeutic effect was obtained. It was reported as follows. 展开更多
关键词 of Vit on is as In into Clinical Study of Vitamin K3 Acupoint Injection In Treating Pelvic Pain
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A clinical study on surgical treatment for perirolandic epilepsy and the predictor for good outcomes 认领 引用
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作者 倪端宇 《外科研究与新技术（中英文）》 2011年第3期217-217,共1页
Objective The purpose of the study was to investigate effective surgical procedure for perirolandic epilepsy and the predictor for good outcomes. Methods We collected 21 subjects who underwent epilepsy surgeries conse... Objective The purpose of the study was to investigate effective surgical procedure for perirolandic epilepsy and the predictor for good outcomes. Methods We collected 21 subjects who underwent epilepsy surgeries consecutively in Beijing Institute of Functional 展开更多
关键词 FCD A clinical study on surgical treatment for perirolandic epilepsy and the predictor for good outcomes
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The clinical study of modified total aortic arch replacement and stent elephant trunk technique treatment for patients with DeBakey Ⅰ thoracic aortic dissection 认领 引用
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作者 吴智勇 《外科研究与新技术（中英文）》 2011年第3期176-176,共1页
Objective To summarize the clinical study of modified total aortic arch replacement and stent elephant trunk technique treatment to patients with DeBakey Ⅰ thoracic aortic dissection. Methods From January 2006 to Oct... Objective To summarize the clinical study of modified total aortic arch replacement and stent elephant trunk technique treatment to patients with DeBakey Ⅰ thoracic aortic dissection. Methods From January 2006 to October 2010,101 cases of DeBakeyⅠaortic dissection were treated by modified total arch replacement and stent elephant trunk technique,in which emergencey surgery were performed on 73 cases. There were 76 male and 25 展开更多
关键词 The clinical study of modified total aortic arch replacement and stent elephant trunk technique treatment for patients with DeBakey thoracic aortic dissection
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Clinical study of chemotherapy-related cognitive impairment in patients with non-Hodgkin lymphoma 认领 引用 被引量：2
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作者 Qiang-Li Wang Hai-Yan Xu +3 位作者 Yi Wang Yin-Ling Wang Pei-Nan Lin Zhong-Lei Chen 《World Journal of Psychiatry》 SCIE 2024年第7期1062-1067,共6页
BACKGROUND Chemotherapy for malignant tumors can cause brain changes and cognitive impairment,leading to chemotherapy-induced cognitive impairment(CICI).Current research on CICI has focused on breast cancer and Hodgki... BACKGROUND Chemotherapy for malignant tumors can cause brain changes and cognitive impairment,leading to chemotherapy-induced cognitive impairment(CICI).Current research on CICI has focused on breast cancer and Hodgkin’s lymphoma.Whether patients with non-Hodgkin’s lymphoma(NHL)undergoing chemo-therapy have cognitive impairment has not been fully investigated.therapy have cognitive impairment has not been fully investigated.AIM To investigate whether NHL patients undergoing chemotherapy had cognitive impairments.METHODS The study included 100 NHL patients who were required to complete a compre-hensive psychological scale including the Brief Psychiatric Examination Scale(MMSE)at two time points:before chemotherapy and within 2 wk of two chemo-therapy courses.A language proficiency test(VFT),Symbol Number Pattern Test(SDMT),Clock Drawing Test(CDT),Abbreviated Daily Cognition Scale(ECog-12),Prospective and Retrospective Memory Questionnaire,and Karnofsky Perfor-mance Status were used to assess cognitive changes before and after chemo-therapy.RESULTS The VFT scores for before treatment(BT)and after treatment(AT)groups were 45.20±15.62,and 42.30±17.53,respectively(t-2.16,P<0.05).The CDT scores were 8(3.5-9.25)for BT and 7(2.5-9)for AT groups(Z-2.1,P<0.05).Retrospective memory scores were 13.5(9-17)for BT and 15(13-18)for AT(Z-3.7,P<0.01).The prospective memory scores were 12.63±3.61 for BT and 14.43±4.32 for AT groups(t-4.97,P<0.01).The ECog-12 scores were 1.71(1.25-2.08)for BT and 1.79(1.42-2.08)for AT groups(Z-2.84,P<0.01).The SDMT and MMSE values did not show a significant difference between BT and AT groups.CONCLUSION Compared to the AT group,the BT group showed impaired language,memory,and subjective cognition,but objec-tive cognition and execution were not significantly affected. 展开更多
关键词 Non-Hodgkin’s lymphoma Hodgkin lymphoma Lymphoma cognitive impairment Chemotherapy-related cogni-tive impairment Clinical study
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A review of the epidemic and clinical study on scrub typhus in China(2010-2020) 认领 引用 被引量：1
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作者 XIE Xiao-fei WANG Gao-yu +6 位作者 HUANG Yi TANG Chuan-ning PENG Ruo-yan HU Xiao-yuan DU Jiang QIN Ai-ping YIN Fei-fei 《Journal of Hainan Medical University》 CAS 2023年第19期57-61,共5页
Scrub typhus is an acute febrile vector-borne zoonotic disease caused by the obligate intracellular growth bacterium Orientia tsutsugamushi(Ot).Mites are the primary vectors and rodents play a pivotal role in the tran... Scrub typhus is an acute febrile vector-borne zoonotic disease caused by the obligate intracellular growth bacterium Orientia tsutsugamushi(Ot).Mites are the primary vectors and rodents play a pivotal role in the transmission of scrub typhus.Due to the climate warming,increased human activity and other factors,cases of scrub typhus have been increased sharply during the past decade in China,especially in the northern China.To understand the incidence trend,epidemic pattern,clinical sign,diagnosis and therapy of this diseases as well as genotype evolution of Orientia tsutsugamushi,we summarized and analyzed the current knowledge of scrub typhus in China from 2010 to 2020.The data indicated that the dominate genotypes of scrub typhus in China were Karp,Kato and Gilliam.Although the disease was distributed national wide,Yunnan,Guangzhou and Fujian showed the highest incidence rate.The main vector of scrub typhus in southwest,middle east and southeast of China appeared a geographic preference respectively.Seasonal timing,age and occupation were the key factors that relate to the peak incidence of scrub typhus.Notably,farmer was the occupation with the highest risk of Ot infection.Further study on the epidemic characteristics,risk factors,diagnosis and treatments of scrub typhus will be of benefit to a comprehensive guideline for prevention and control of this ancient disease. 展开更多
关键词 Scrub typhus Orientia tsutsugamushi Epidemic region Trend Clinical study
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