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Intermittent hypoxic perconditioning improves cognitive function in a mouse model of vascular cognitive impairment and dementia with comorbidities by recovering cerebral blood flow 认领 引用
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作者 Feiyang Jin Zhengming Tian +9 位作者 Yuying Guan Yuning Li Yakun Gu Mengyuan Guo Qianqian Shao Yingxia Liu Xiuhai Guo Zhenzhen Quan Jia Liu Xunming Ji 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第6期2415-2424,共10页
Vascular cognitive impairment and dementia is a debilitating neurological disorder caused by chronic cerebral hypoperfusion,for which no effective causative treatments are currently available.Intermittent hypoxia has ... Vascular cognitive impairment and dementia is a debilitating neurological disorder caused by chronic cerebral hypoperfusion,for which no effective causative treatments are currently available.Intermittent hypoxia has been shown to enhance cerebral blood flow in mice,but its efficacy in a model of vascular cognitive impairment and dementia remains unclear.In this study,we established a mouse model of vascular cognitive impairment and dementia by bilateral carotid artery stenosis.Intermittent hypoxia was induced before and after this stenosis.We found that intermittent hypoxia increased cerebral blood flow,oxygen saturation,and microcirculation in the prefrontal cortex and hippocampus in the model mice,without causing neurovascular damage.Additionally,intermittent hypoxia significantly improved cognitive function in the mouse model of vascular cognitive impairment and dementia,with perconditioning showing greater efficacy than preconditioning.Improvements in cerebral microcirculation and blood flow were positively correlated with cognitive recovery.Even in a mouse model of vascular cognitive impairment and dementia with comorbidities induced by a high-fat,high-fructose diet,intermittent hypoxic perconditioning demonstrated protective effects on cognitive function.Proteomic analysis indicated that mitochondrial protection is a key mechanism,particularly through upregulating NDUFB8 expression and increasing the activity of mitochondrial complex I.These findings suggest that intermittent hypoxia is a potential non-invasive strategy for the prevention and treatment of vascular cognitive impairment and dementia. 展开更多
关键词 bilateral carotid artery stenosis cerebrovascular microcirculation chronic cerebral hypoperfusion cognitive function high fat-high fructose diet hippocampus intermittent hypoxia mitochondrial respiratory chain prefrontal cortex vascular cognitive impairment and dementia
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Differential impacts of job-related vs leisure-related physical activity on depressive and cognitive function among middle-aged and elderly adults 认领 引用
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作者 Qian-Ru Zhao Li Xie +5 位作者 Bing Li Xiang-Ya Zhao Sheng-Nan Yang Yi Yang Ling Dong Qian Wang 《World Journal of Psychiatry》 SCIE 2026年第2期56-70,共15页
BACKGROUND While several studies have explored the relationship among physical activity(PA),depressive symptoms,and cognitive health,the distinct effects of PA performed for occupational vs recreational purposes remai... BACKGROUND While several studies have explored the relationship among physical activity(PA),depressive symptoms,and cognitive health,the distinct effects of PA performed for occupational vs recreational purposes remain underexplored.AIM To investigate the differential impacts of job-related vs leisure-related physical activities on depressive symptoms and cognitive function among adults aged 45 years and older in China.METHODS Data were extracted from the China Health and Retirement Longitudinal Study,encompassing 16476 participants.Depressive symptoms were assessed using the 10-item Center for Epidemiologic Studies Depression Scale,and cognitive function was evaluated using the Mini-Mental State Examination.PA was categorized by purpose(job-related vs leisure-related)and intensity(vigorous,moderate,and low),with frequency and duration measured in metabolic equivalent hours per day.An external validation using an independent clinical sample(n=200)was conducted.RESULTS Vigorous-intensity PA for job demands(JVPA)was significantly associated with increased depressive symptoms[P=0.011,odds ratio(OR)=1.003],indicating that high-intensity job-related activities may exacerbate mental health issues.Moderate-intensity PA for entertainment or exercise(EMPA)was inversely associated with depressive symptoms(P=0.030,OR=0.999),suggesting that moderate-intensity leisure activities can reduce depressive symptoms.For cognitive function,the total PA for job demands was correlated with cognitive decline(P=0.004,OR=1.008),with the frequency of JVPA showing a positive association.However,EMPA was linked to reduced cognitive decline(P=0.018,OR=0.998).Clinical validation results were consistent with those obtained from the database,further supporting the reliability of the findings.CONCLUSION JVPA exacerbates depressive symptoms and cognitive impairment,whereas EMPA mitigates depression and supports cognitive health.Targeted interventions promoting leisure-related PA may enhance mental and cognitive well-being in older adults. 展开更多
关键词 Depressive symptoms Cognitive function Physical activity Job-related activity Leisure-related activity Aging China Health and Retirement Longitudinal Study
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Effects of physical activity interventions on fundamental movement skills and cognitive function in early childhood:A systematic review and network meta-analysis 认领 引用
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作者 Shan Jiang Nan Zeng +4 位作者 Johan Y.Y.Ng Kar Hau Chong Taoran Zeng Suzannie K.Y.Leung Amy S.Ha 《Journal of Sport and Health Science》 SCIE CAS CSCD 2026年第3期37-50,共14页
Background:Health benefits have been reported for many physical activity(PA)interventions for improving fundamental movement skills(FMS)and cognitive function(CF),but the most effective type of PA interventions for em... Background:Health benefits have been reported for many physical activity(PA)interventions for improving fundamental movement skills(FMS)and cognitive function(CF),but the most effective type of PA interventions for emhancing FMS and CF in early childhood remain unknown.Thus,the study aimed to determine the effects of PA interventions in enhancing FMS and CF among young children and to establish the optimal types of PA interventions.Methods:Six electronic databases(PubMed,OVID,SPORTDiscus,Scopus,Web of Science,and Cochrane)were searched for studies from inception to March 17,2024.Randomized controlled trials(RCTs)were included in this study if they reported outcomes related to FMS,CF,or both associated with PA interventions.Effect sizes were calculated and performed as Hedges'g.The hierarchy of competing interventions was established using the surface under the cumulative ranking curve(SUCRA).Risk of bias was independently assessed using the Cochrane Riskof-Bias 2.Results:This analysis included 38 studies with 5237 young children,with sample sizes ranging from 32 to 897 participants.The types of PA interventions analyzed included active play/free play/unstructured PA(AP),general structured PA(GSPA),FMS-targeted PA programs(FMSprograms),cognitively-engaging PA programs(CPA),multilevel PA interventions(MPA),and exergaming.PA interventions had a large,pooled effect size for total FMS(g=0.96;95%CI:0.45-1.46;p<0.01;I2=94%).For CF,a small-to-moderate pooled effect size was found(g=0.39;95%CI:0.18-0.60;p<0.01;I2=88%).PA interventions longer than 3 months showed fewer benefits for FMS(p<0.01).The network meta-analysis showed that FMS-programs(standardized mean difference((SMD)=1.55,95%CI:0.98-2.11,SUCRA=98.3%)and GSPA(SMD=0.94,95%CI:0.05-1.85,SUCRA=69.8%)significantly improved total FMS compared to AP.For locomotor skills(LMS),exergaming ranked highest(SUCRA=79.3%),followed by FMS-programs(75.9%)and GSPA(61.6%).However,despite its top ranking,exergaming's effect estimate was not statistically significant(SMD=1.38,95%CI:-0.08 to 2.85).For object control skills(OCS),exergaming again ranked highest(SUCRA=91.9%)and showed the largest significant effect(SMD=2.38,95%CI:0.96-3.80),followed by FMS-programs(SUCRA=78.5%)and GSPA(SUCRA=53.7%).FMS-programs,GSPA,MPA,and UC also significantly improved OCS compared to AP.While no significant differences were observed across PA interventions for most CF domains,exergaming had a significant positive effect on working memory(SMD=1.41,95%CI:0.07-2.75).The certainty of evidence varied from low to moderate.Conclusion:These findings emphasize the importance of PA interventions in improving FMS and CF in early childhood.FMS-programs and GSPA appear to be the most effective approaches for enhancing total FMS,while exergaming showed the highest ranking for LMS and OCS,with a significant impact on OCS but uncertainty in LMS improvements.Additionally,exergaming had a positive effect on working memory,suggesting its potential cognitive benefits. 展开更多
关键词 Physical activity Fundamental movement skills Cognitive function Early childhood
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Effects of using multivitamins as dietary supplements on cognitive function in older adults:a systematic review and meta-analysis 认领 引用
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作者 Yijia Xu YueqiaoWang +1 位作者 Guoxun Chen Rui Li 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第1期1-12,共12页
Multivitamins were widely used health supplements that replenished essential nutrients in the human body.Despite their popularity,the impact of multivitamins on the cognitive function of older adults remained unclear ... Multivitamins were widely used health supplements that replenished essential nutrients in the human body.Despite their popularity,the impact of multivitamins on the cognitive function of older adults remained unclear and contentious.This study offered a comprehensive review and meta-analysis of research published until June 2024,analyzing the effects of multivitamins on various cognitive functions in individuals aged 65 and older.We included ten randomized controlled trials encompassing 13,600 participants from multiple databases.These studies evaluated the impact of multivitamins on reasoning,memory,learning,visual perception,idea production,cognitive speed,psychomotor abilities,and higher cognitive functions.Our meta-analysis revealed that multivitamins significantly enhanced delayed free recall (standardized mean difference(SMD)=0.09,95%confidence interval(CI)=[0.05,0.13],P<0.0001).However,they had no substantial effects on immediate free recall(SMD=0.85,95%CI=[-0.18,1.90],P=0.11),idea production(SMD=0.00,95%CI=[-0.04,0.03],P=0.86),or cognitive speed(SMD=0.34,95%CI=[-0.07,0.74],P=0.11).Thus,while multivitamins facilitated delayed free recall,they did not significantly improve other cognitive functions in older adults. 展开更多
关键词 Multivitamins Cognitive function Older adults Meta-analysis
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Effect of transcutaneous auricular vagus nerve stimulation on the improvement of cognitive function in older patients with schizophrenia:A randomised controlled study 认领 引用
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作者 Wei Xiang Junjie Yang +9 位作者 Yan Chen Shengke Pan Li Bai Shixing Qian Yuchao Shi Xinyi Cao Yuan Shen Xiaochen Tang Wei Li Chunbo Li 《General Psychiatry》 CAS CSCD 2026年第1期45-54,共10页
Aims To investigate the efficacy and safety of transcutaneous auricular vagus nerve stimulation(taVNS)in improving cognitive function in older inpatients with schizophrenia.Design Randomised controlled trial.Setting C... Aims To investigate the efficacy and safety of transcutaneous auricular vagus nerve stimulation(taVNS)in improving cognitive function in older inpatients with schizophrenia.Design Randomised controlled trial.Setting Cognitive improvement in hospitalised older patients with schizophrenia in Shanghai.Participants Fifty-one older inpatients with schizophrenia in Shanghai Mental Health Center.Intervention The taVNS electrodes were placed on the skin with vagus nerve distribution in the taVNS group,whereas the electrodes were placed on the skin without vagus nerve distribution in the sham taVNS group.taVNS parameters included 25 Hz,the maximum tolerated current intensity(apparatus maximum load current ≤6 mA) and one 30-min session per day for 2 weeks,for a total of 10 interventions.Measurements The primary outcome was a neurocognitive assessment.Safety was the secondary outcome measure.After each treatment session,adverse reactions were assessed using the self-administered Adverse Reaction Assessment Scale.Four subtests of the Cambridge Neuropsychological Test Automated Battery were further considered:reaction time(RTI),paired associate learning(PAL),multitasking test(MTT) and spatial working memory(SWM).Results The time and interaction effects of betweengroup search errors were statistically significant(F=9.51,p <0.001).Compared to the sham taVNS,taVNS improved SWM performance in older patients with schizophrenia.Furthermore,the SWM performance after a single session of taVNS showed fewer errors in the taVNS group,whereas no such improvement was observed in the sham taVNS group.Unlike in SWM,there were no significant between-group differences in RTI,PAL or MTT after either a single stimulation or a session of 10 stimulations.Conclusions taVNS may have the potential to improve SWM in older patients with schizophrenia. 展开更多
关键词 Older Patients Transcutaneous Auricular Vagus Nerve Stimulation Schizophrenia Cognitive Function Randomised Controlled Trial transcutaneous auricular vagus nerve stimulation tavns vagus nerve distribution cognitive improvement
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Serum adiponectin and cognitive function in Alzheimer’s disease with comorbid depression 认领 引用
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作者 Chong Song Wei Zhan +2 位作者 Jia-Yu Tang Zhu-Hui Liu Yong-Pan Huang 《World Journal of Psychiatry》 SCIE 2026年第7期347-355,共9页
BACKGROUND Depression is a highly prevalent comorbidity in Alzheimer’s disease(AD),exacerbating cognitive decline and worsening prognosis.Adiponectin(APN),an adipokine with anti-inflammatory and neuroprotective prope... BACKGROUND Depression is a highly prevalent comorbidity in Alzheimer’s disease(AD),exacerbating cognitive decline and worsening prognosis.Adiponectin(APN),an adipokine with anti-inflammatory and neuroprotective properties,has been implicated in both conditions,yet its role in the comorbid state remains unclear.We hypothesized that serum APN levels would be significantly reduced in these patients and would independently correlate with the severity of cognitive impairment.AIM To investigate the association between serum APN levels and cognitive function in AD patients with comorbid depression.METHODS This observational study enrolled 60 AD patients with depression and 60 healthy controls from a hospital neurology department.The observation group was subclassified into mild,moderate,and severe groups using the Clinical Dementia Rating Scale.Cognitive function was evaluated using the Montreal Cognitive Assessment(MoCA)and the Mini-Mental State Examination(MMSE).Serum APN levels were determined via ELISA,and metabolic/inflammatory markers were also assessed.Data were analyzed using t-tests,ANOVA,Pearson correlation,and multiple linear regression.RESULTS In the observation group serum APN levels(6.67±1.99μg/mL)and MoCA/MMSE scores were considerably lower than in control group(12.53±2.87μg/mL;all P<0.001).Within the observation group,APN levels and cognitive scores decreased progressively with worsening disease severity(all P<0.001).Serum APN was positively associated with MoCA(r=0.781,P<0.001)and MMSE scores(r=0.643,P<0.001).After adjusting for metabolic/inflammatory factors,APN remained an independent predictor of MoCA scores(t=8.009,P<0.001).CONCLUSION Serum APN levels are markedly reduced in AD patients with depression and closely correlate with impaired cognition.APN may represent a potential biomarker for assessing cognitive status in this population. 展开更多
关键词 Alzheimer’s disease Depression Adiponectin Cognitive function Correlation
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Potential role of FNDC5 in exercise-induced improvement of cognitive function 认领 引用
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作者 Ruobing ZHAO Xuchang ZHOU +2 位作者 Dongxue WANG Haifeng TANG Guoxin NI 《Journal of Zhejiang University-SCIENCE B》 SCIE CAS CSCD 2025年第6期557-572,共16页
Cognitive dysfunction often occurs in Alzheimer’s disease,Parkinson’s disease,cerebrovascular disease,or other neurodegenerative diseases,and can significantly impact the life quality of patients and create serious ... Cognitive dysfunction often occurs in Alzheimer’s disease,Parkinson’s disease,cerebrovascular disease,or other neurodegenerative diseases,and can significantly impact the life quality of patients and create serious social,psychological,and economic burdens for individuals and their families.Numerous studies have confirmed that exercise can slow the decline in cognitive function through multiple pathways,in which fibronectin type III domain-containing protein 5(FNDC5)plays an important role.However,the current research on the modulation of FNDC5 by exercise and its ability to improve hippocampal cognitive function lacks a systematic and comprehensive understanding.Therefore,this review focuses on the latest research progress regarding the role of exercise-induced FNDC5 in cognitive function,systematically reviews the positive effects of FNDC5 on cognitive function impairment caused by various factors,and clarifies the specific mechanisms by which exerciseinduced FNDC5 improves cognitive function by inhibiting neuroinflammation and improving hippocampal neurogenesis and hippocampal synaptic plasticity.Based on the existing literature,we also identify the areas that require further research in this field.Overall,this review provides a theoretical basis for exercise-based prevention and improvement of cognitive function impairment. 展开更多
关键词 Exercise Fibronectin typeⅢdomain-containing protein 5(FNDC5) Irisin Cognitive function Hippocampus
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Factors influencing cognitive function in Chinese elderly individuals:The role of traditional Chinese medicine in a large-scale cross-sectional study 认领 引用
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作者 Houqin Li Ran Chen +4 位作者 Jing Xia Feiyu He Yan Zhang Shulan Tang Cheng Ni 《Journal of Traditional Chinese Medical Sciences》 CAS CSCD 2025年第2期221-230,共10页
Objective:To identify key factors influencing cognitive function in the elderly,including traditional Chinese medicine(TCM)constitutional classification,and to rank their relative importance.Methods:We used cross-sect... Objective:To identify key factors influencing cognitive function in the elderly,including traditional Chinese medicine(TCM)constitutional classification,and to rank their relative importance.Methods:We used cross-sectional data from seven geographical regions across Chinese mainland.The Changsha version of the Montreal Cognitive Assessment was used to assess cognitive function.A“least absolute shrinkage and selection operator”(LASSO)model,multivariate linear regression analysis,and random forest(RF)model were used.Subgroup analyses were performed to examine the correlation between key TCM constitution types and cognitive function in different population subgroups.Results:A total of 24803 individuals aged 60 and above were included in the study.We selected 18 influential factors using the LASSO model.Higher education,being married,and having insurance were positively correlated with cognitive function in the elderly(all P<0.05).In contrast,poor sleep,vision impairment,hearing impairment,basic activities of daily living disability,instrumental activities of daily living disability,depression,hypertension,coronary heart disease,diabetes,stroke,yang-deficiency constitution(YADC),yin-deficiency constitution(YIDC),qi deficiency constitution(QDC),and blood stasis constitution(BSC)were negatively correlated with cognitive function(all P<0.05).YIDC and BSC affected all dimensions of cognitive function(all P<0.05).YADC mainly affected attention,language,abstraction(verbal analogies),memory,and orientation to time and place dimensions(P<0.001).QDC mainly affected language and abstraction(verbal analogies)dimensions(P<0.05).The negative correlations between BSC,YADC,YIDC,and QDC scores and cognitive function revealed statistically significant dif-ferences across most subgroups.The RF model identified education,BSC,and poor sleep quality as the three most influential factors in our study.Conclusion:BSC,YADC,YIDC,and QDC were associated with cognitive decline in the elderly.Our findings provide new perspectives and significant references for interventions for early-stage cognitive disorders. 展开更多
关键词 Cognitive function Influencing factors Traditional Chinese medicine constitution Elderly individuals
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ZnO-SnO2/WO3-x heterojunction artificial synapse for realization and integration of multiple biological cognitive functions 认领 引用 被引量：1
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作者 Pengfei Sun Ruidong Li +3 位作者 Haotian Meng Tao Sun Song Gao Yang Li 《International Journal of Extreme Manufacturing》 SCIE EI CAS CSCD 2025年第5期433-445,共13页
In current memristor-based neuromorphic computing research,several studies face the challenge of realizing only a single function at a time or having isolated functions.This limitation is particularly evident when sim... In current memristor-based neuromorphic computing research,several studies face the challenge of realizing only a single function at a time or having isolated functions.This limitation is particularly evident when simulating biological cognition,as the overall synergy between multiple cognitive functions is difficult to represent.In this work,a high-performance heterojunction memristor is presented at first.The memristor-based neural network and functional circuit are further implemented to realize and integrate multiple cognitive functions.Specifically,the proposed photoelectric memristor has the structure of Ag/ZnO-SnO2/WO3-x/ITO,it exhibits various synaptic behaviors under external modulations,which are characterized by good stability and repeatability.Based on this device,a neural network is built to realize the basic recognition function in biological cognition.The recognition results are translated into different labelled voltage signals and subsequently fed into a memristor-based functional circuit.By leveraging memory characteristics and tunable conductance of the memristor,and controlling the specific circuit functionalities,the input signals are processed to produce different outputs representing various cognitive functions.This methodology allows the realization and integration of recognition,memory,learning,association,relearning,and forgetting into one single system,thereby enabling a more comprehensive and authentic simulation of biological cognition.This work presents a novel memristor and a method for achieving and integrating multiple neuromorphic computing functions within a single system,providing a successful example for achieving complete biological function. 展开更多
关键词 optoelectronicdevice oxide heterojunction memristor neuromorphic computing multiple biological cognitive functions low-power consumption system
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Mutual Relationship between Grip Strength and Cognitive Function in Chinese Middle-Aged and Elderly People over 10 Years:A Cross-Lagged Panel Analysis 认领 引用 被引量：1
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作者 Jiaqi Wang Ye Ruan +5 位作者 Yanfei Guo Shuangyuan Sun Anli Jiang Yujun Dong Yan Shi Fan Wu 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2025年第10期1308-1313,共6页
In 2019,China had over 13.14 million dementia cases,with incidence rates of(56.47–207.08)/100,000[1].Early cognitive impairment—a key dementia symptom—reduces quality of life,increases care dependence,and lowers su... In 2019,China had over 13.14 million dementia cases,with incidence rates of(56.47–207.08)/100,000[1].Early cognitive impairment—a key dementia symptom—reduces quality of life,increases care dependence,and lowers survival in older adults[2].A decline in physical function can also be observed in older adults with increasing age.Grip strength has been shown to be a marker of overall physiological function in older adults. 展开更多
关键词 decline physical function physiological function cognitive function cognitive impairment Chinese middle aged elderly grip strength cross lagged panel analysis dementia
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Effects of eccentric resistance training after stroke on body function,activities of daily living and cognitive function:A review 认领 引用 被引量：1
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作者 Maria Ramoneda-Rabat Josep Medina-Casanovas +1 位作者 Maria Betina Nishishinya Aquino Myriam Guerra-Balic 《Sports Medicine and Health Science》 CSCD 2025年第2期85-101,共17页
Impairments on body function,activities of daily living(ADL)and cognition are common after stroke.Eccentric resistance training(ERT)may be implemented to improve them.The primary objectives were to evaluate whether ER... Impairments on body function,activities of daily living(ADL)and cognition are common after stroke.Eccentric resistance training(ERT)may be implemented to improve them.The primary objectives were to evaluate whether ERT improves body function,ADL and cognition after stroke.The secondary objectives were to evaluate whether ERT improves strength,gait,quality of life,and self-perceived health.Seven electronic databases were searched:Cochrane Central Register of Controlled Trials,Cochrane Stroke Group Trials Register,PubMed,Epistemonikos,Embase,SPORTDiscus,and WHO International Clinical Trials Registry Platform.Last search was run in December 2023,including studies since 2012.Selection criteria were studies with stroke participants of both sexes,aged 18 or more,with an intervention based on ERT.Accepted languages were English,Spanish or French.First search was done in pairs.Authors removed duplicate studies and those which did not meet inclusion criteria through title and abstracts.Finally,all authors,independently,screened the final search results and extracted data.Of 68 records identified,15 were eligible and 6 were finally included(with moderate risk of bias),analyzing 159 participants.Body function(4 interventions,n=84),gait(4 interventions,n=115)and strength(3 interventions,n?78)showed significantly better results when ERT was performed.Meta-analysis could not be done because of the few studies and their heterogeneity.This review provided low-moderate quality evidence suggesting that ERT might be effective at improving body function,strength,and gait after stroke.Besides,no harm was documented,and it was well-accepted. 展开更多
关键词 Stroke Eccentric resistance training Body function Activities of daily living Cognitive function
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Cognitive function disparities among atrial fibrillation patients with varying comorbidities 认领 引用
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作者 Mei-Qi ZHAO Ting SHEN +6 位作者 Man-Lin ZHAO Jia-Xin LIU Mei-Lin XU Xin LI Liu HE Yu KONG Chang-Sheng MA 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2025年第10期859-870,共12页
BACKGROUND Mild cognitive impairment(MCI)is common in atrial fibrillation(AF)patients and may develop earlier in those with multiple cardiovascular comorbidities,potentially impairing self-management and treatment adh... BACKGROUND Mild cognitive impairment(MCI)is common in atrial fibrillation(AF)patients and may develop earlier in those with multiple cardiovascular comorbidities,potentially impairing self-management and treatment adherence.This study aimed to characterize the prevalence and profile of MCI in AF patients,examine its associations with cardiovascular comorbidities,and assess how these comorbidities influence specific cognitive domains.METHODS This cross-sectional study analyzed data from AF patients who underwent cognitive assessment between 2017 and 2021.Cognitive status was categorized as MCI or non-MCI based on the Montreal Cognitive Assessment.Associations between comorbidities and MCI were assessed by logistic regression,and cognitive domains were compared using the Mann-Whitney U test.RESULTS Of 4136 AF patients(mean age:64.7±9.4 years,64.7%male),33.5%of patients had MCI.Among the AF patients,31.2%of patients had coronary artery disease,20.1%of patients had heart failure,and 18.1%of patients had hypertension.88.7%of patients had left atrial enlargement,and 11.0%of patients had reduced left ventricular ejection fraction.Independent factors associated with higher MCI prevalence included older age(OR=1.04,95%CI:1.03-1.05,P<0.001),lower education level(OR=1.51,95%CI:1.31-1.73,P<0.001),hypertension(OR=1.28,95%CI:1.07-1.52,P=0.001),heart failure(OR=1.24,95%CI:1.04-1.48,P=0.020),and lower left ventricular ejection fraction(OR=1.43,95%CI:1.04-1.98,P=0.028).A higher CHA2DS2-VASc score(OR=1.27,95%CI:1.22-1.33,P<0.001;≥2 points vs.<2 points),and greater atherosclerotic cardiovascular disease burden(OR=1.45,95%CI:1.02-2.08,P=0.040;2 types vs.0 type)were linked to increased MCI risk.These above factors influenced various cognitive domains.CONCLUSIONS MCI is common in AF and closely associated with cardiovascular multimorbidity.Patients with multiple comorbidities are at higher risk,highlighting the importance of routine cognitive assessment to support self-management and integrated care. 展开更多
关键词 Cognitive function Comorbidities Cardiovascular disease Atrial fibrillation mild cognitive impairment mci cardiovascular comorbiditiespotentially Mild cognitive impairment Self management
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Multimodal analgesia in cardiac surgery:Impact on postoperative medication consumption and cognitive function 认领 引用
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作者 Qin Wang Xiao-Qiong Yan +4 位作者 Xiao-Mei Ma Rui Yan Zhi-Hua Wang Yu-Jie Ma Hai-Bin Wang 《World Journal of Cardiology》 2025年第5期69-76,共8页
BACKGROUND Patients who undergo cardiac surgery often face postoperative pain and potential cognitive issues.Multimodal analgesia may address these problems.We hypothesized that multimodal analgesia can reduce opioid ... BACKGROUND Patients who undergo cardiac surgery often face postoperative pain and potential cognitive issues.Multimodal analgesia may address these problems.We hypothesized that multimodal analgesia can reduce opioid use and improve cognitive recovery.AIM To investigate the effects of multimodal analgesia on postoperative opioid consumption and cognitive recovery in patients who underwent cardiac surgery.METHODS A prospective,randomized controlled trial at General Hospital from January 2020 to April 2023 recruited a total of 150 adult patients who underwent elective cardiac surgery.The patients were randomly divided into two groups.Group A had patient-controlled intravenous analgesia with sufentanil and flurbiprofen axil.Group B had flurbiprofen axil and paravertebral nerve block.Data were analyzed with appropriate statistical methods.RESULTS Group B had lower postoperative patient-controlled intravenous analgesia drug consumption(2.21 mL/hour vs 4.26 mL/hour,P<0.001),shorter extubation time(2.32 hours vs 3.81 hours,P<0.001),and intensive care unit stay(15.32 h vs 28.63 h,P<0.001).Visual Analogue Scale pain scores were lower in group B(P<0.001).Group B had fewer postoperative complications(no respiratory depression vs 37.9%in group A,P<0.05),a lower postoperative cognitive dysfunction incidence(16.0%vs 28.0%,P<0.05),and higher Barthel Index scores(P<0.05).CONCLUSION Multimodal analgesia with paravertebral nerve block and flurbiprofen axil reduces opioid use and improves cognitive outcomes in patients who underwent cardiac surgery. 展开更多
关键词 Multimodal analgesia Cardiac surgery Postoperative medication consumption Cognitive function Pain management
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Effects of Cognitive Stimulation Intervention on Cognitive Function and Depression in Older Adults with Mild Dementia: A Quasi-Experimental Study 认领 引用
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作者 Ya-Wen Chang Hsiu-Chuan Chen +3 位作者 Shih-Chi Chung Wai-Lam Lao Ching-Pyng Kuo Shu-Hsin Lee 《International Journal of Mental Health Promotion》 2025年第7期979-994,共16页
Background:Cognitive stimulation therapy(CST)is a non-pharmacological intervention designed to improve cognitive function and emotional well-being in individuals with dementia.However,limited studies have evaluated it... Background:Cognitive stimulation therapy(CST)is a non-pharmacological intervention designed to improve cognitive function and emotional well-being in individuals with dementia.However,limited studies have evaluated its efficacy in Chinese-speaking populations.This study aimed to assess the effects of a 12-week cognitive stimulation interventiononcognitive functionanddepression inolder adultswithmilddementia.Methods:This quasiexperimental study employed a repeated measures design with a non-randomized experimental and control group.Participants(N=40)65 years and older with mild dementia(clinical dementia rating(CDR)=0.5–1)were recruited from a regional hospital and dementia care center in Taiwan.The experimental group(n=20)received a structured CST intervention for 12 weeks(two sessions per week,120 min per session),while the control group(n=20)received routine care.Cognitive function was assessed using the Saint Louis University Mental Status(SLUMS)exam,and depression was measured using the Chinese version of the Cornell Scale for Depression in Dementia(CSDD-C).Data were collected at baseline,4,8,and 12 weeks and analyzed using repeatedmeasures ANOVA and generalized estimating equation(GEE)modeling.Results:The experimental group showed significant improvements in cognitive function compared to the control group(SLUMS score:baseline 16.1±4.8 to 12th week 19.3±5.0,p<0.001).Depression levels decreased significantly in the experimental group but not in the control group(p<0.05).The GEE analysis showed that the improvement in cognitive function was positively associated with education level and duration,but declined with increasing age.Similarly,depression was lower in participants with higher educational levels and inmen.Conclusions:The findings support the efficacy of CST in improving cognitive function and reducing depression in older adults with mild dementia.The results highlight the importance of the duration of the intervention and individual cognitive reserve in modulating treatment outcomes. 展开更多
关键词 Cognitive stimulation therapy(CST) mild dementia cognitive function depression quasiexperimental study
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Mood symptoms,cognitive function,and changes of brain hemodynamics in patients with COVID-19:A functional near-infrared spectroscopy study 认领 引用
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作者 Wen-Jin Ma Ruo-Chao Yuan +9 位作者 Zi-Yu Peng Qian Wu Manal Al-Matary Hui-Shu Yang Peng Cheng Guang-Ju Zhao Chao-Chao Lu Yue-Xin Zhang Jia-Kun Hong Wei-Hui Li 《World Journal of Psychiatry》 SCIE 2025年第3期193-215,共23页
BACKGROUND Many patients with coronavirus disease 2019(COVID-19)may experience emotional issues and cognitive impairment.However,it remains unclear whether the brain mediates the impact of COVID-19 on the emergence of... BACKGROUND Many patients with coronavirus disease 2019(COVID-19)may experience emotional issues and cognitive impairment.However,it remains unclear whether the brain mediates the impact of COVID-19 on the emergence of psychopathological symptoms.It remains unclear whether anxiety and depression are caused by stressors or viral infection.AIM To use functional near-infrared spectroscopy(fNIRS)to detect cortical hemodynamic changes in patients with COVID-19 and their relationship with mental symptoms(mainly depression and anxiety),to investigate whether COVID-19 causes these changes by affecting brain function.METHODS A total of 58 subjects,comprising 29 patients with first acute COVID-19 infection and 29 healthy controls without COVID-19 infection and without anxiety or depression were recruited.Then cortical activation during the performance of the verbal fluency test(VFT)and brain connectivity during the resting state(rs)were evaluated by 53-channel fNIRS.For the COVID-19-infected group,Patient Health Questionnaire-9(PHQ-9)and General Anxiety Disorder-7(GAD-7)were used to assess the emotional state before fNIRS measures.RESULTS For the rs,compared to the uninfected group,the infected group exhibited lower rs functional connectivity(FC)in the dorsolateral prefrontal cortex(DLPFC),which was correlated with both the PHQ score and GAD score.During the VFT,the infected group exhibited significantly lower cortical activation than the uninfected group in both Broca-left and Broca-right.Besides,the integral value in the DLPFC-L showed a significant negative correlation with the PHQ-9 score during the VFT in the infected group.CONCLUSION There were significant differences in the bilateral Broca area and DLPFC between the COVID-19-infected and uninfected groups,which may be the reason why COVID-19 infection impairs cognitive function and language function and leads to psychiatric symptoms.In addition,the rsFC in patients with COVID-19 was positively correlated with the severity of depression and anxiety,which may be related to the fact that the mental symptoms of patients with COVID-19 are characterized by depression and anxiety,rather than depression or anxiety alone.Our study provides evidence that the psychological and emotional issues caused by COVID-19 are not only due to external social factors but also involve more direct brain neural mechanisms and abnormal neural circuits,which also provide insights into the future treatment and prognosis of individuals with COVID-19. 展开更多
关键词 COVID-19 Depression Anxiety Cognitive function Functional near-infrared spectroscopy Verbal fluency test
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Correction:Impact of twice-a-day transcranial direct current stimulation interuention on cognitive function and motor cortex plasticity in patients with Alzheimer's disease 认领 引用
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《General Psychiatry》 CAS CSCD 2025年第5期415-415,共1页
An unauthorised version of the Chinese MMSE was used in this article by the authors without permission from the copyright owner,PAR.Necessary permission has now been retrospectively obtained from PAR.The MMSE is a cop... An unauthorised version of the Chinese MMSE was used in this article by the authors without permission from the copyright owner,PAR.Necessary permission has now been retrospectively obtained from PAR.The MMSE is a copyrighted instrument and may not be used or reproduced in whole or in part,in any form or language,or by any means without the written permission of PAR(www.parinc.com). 展开更多
关键词 transcranial direct current stimulation motor cortex plasticity copyright cognitive function retrospective permission unauthorized version alzheimer's disease
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Meta-analysis of the effect of cognitive stimulation therapy on cognitive function in patients with Alzheimer's disease 认领 引用
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作者 Yi-Ting Lu Xin Zhang Jun Cheng 《World Journal of Psychiatry》 SCIE 2025年第4期310-320,共11页
BACKGROUND There is no effective treatment for Alzheimer's disease(AD),and pharmacological treatment of AD in clinical settings is expensive and prolonged,resulting in a huge psychological and economic burden on t... BACKGROUND There is no effective treatment for Alzheimer's disease(AD),and pharmacological treatment of AD in clinical settings is expensive and prolonged,resulting in a huge psychological and economic burden on the patient's family and caregivers and society as a whole,AD is characterized by progressive,worsening cognitive impairment,and there are currently no drugs that can effectively reverse cognitive impairment.However,it is important to intervene early or delay cognitive impairment so that the condition can be delayed and,ultimately,the burden on patients and families can be reduced through maintenance treatment.It may be that non-pharmacological interventions such as cognitive stimulation therapy(CST)can help with cognitive dysfunction.AIM To provide a better treatment plan for AD patients and delay the deterioration of cognitive function,the effect of CST on cognitive function in AD was studied by Meta-analysis.METHODS Comprehensive search the Chinese and English databases were comprehensively searched by computer.Chinese databases:China Biomedical Literature Database(CBM),Wanfang Database,VIP Database,and China Periodicals Full-text Database(CNKI).The collection time limit is from July 21,2010 to July 21,2022 randomized controlled trials literature on the effects of CST on cognitive function in patients with AD.According to the inclusion and exclusion criteria,literature screening,data extraction,and quality evaluation were performed.Standardized mean difference(SMD)and 95%CI were used as evaluation criteria to evaluate the cognitive function of CST in AD patients.Sensitivity analysis and publication bias detection were performed on the results.Publication bias was assessed using funnel plots,and funnel plot symmetry was assessed with Eggr's test.RESULTS CST can not improve Mental State Examination Scale(MMSE)scores in AD patients.Meta-analysis of CST on MMSE scores showed that the heterogeneity was P=0.14,I2=35%.I2=35%0.1,choose the random effect model to integrate statistics,get SMD=0.02,95%CI:-0.37,0.42,P>0.05.Meta-analysis of CST on AD Cognitive Functioning Assessment Scale scores showed that the heterogeneity was P=0.13,I2=36%.I2=36%0.05,the difference is not statistically significant.Meta-analysis of CST on the cognitive function indicators of patients showed that the heterogeneity was P=0.17,I2=31%.I2=31%0.05,the difference was not statistically significant.CONCLUSION CST may not improve the cognitive function of AD patients,not improve the cognitive function of AD patients,not improve the ability of daily living,and not reduce mental behavior can improve the cognitive function of AD patients. 展开更多
关键词 Cognitive stimulation therapy Alzheimer's disease Meta-analysis Cognitive function
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The Effect of Continuous Positive Airway Pressure Therapy on Daytime Sleepiness and Cognitive Function in Patients with Moderate to Severe OSAHS 认领 引用
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作者 Juan Du Yinping Wang +2 位作者 Long Zhang Rui Lu Ming Cui 《Science International Innovative Medicine》 2025年第3期17-22,共6页
Objective:To explore the effect of continuous positive airway pressure(CPAP)therapy on daytime sleepiness and cognitive function in patients with moderate to severe obstructive sleep apnea-hypopnea syndrome(OSAHS).Met... Objective:To explore the effect of continuous positive airway pressure(CPAP)therapy on daytime sleepiness and cognitive function in patients with moderate to severe obstructive sleep apnea-hypopnea syndrome(OSAHS).Methods:From January to December 2024,60 patients with moderate to severe OSAHS were enrolled and randomly divided into an observation group and a control group,with 30 patients in each group.The observation group received CPAP combined with routine intervention,while the control group only received routine intervention,with a course of 3 months for both groups.Results:After 3 months of intervention,the observation group showed significantly better improvements in the frequency and duration of daytime sleepiness as well as all dimensions of cognitive function compared with the control group,and the differences were statistically significant(P<0.05).Conclusion:CPAP therapy can effectively relieve daytime sleepiness in patients with moderate to severe OSAHS,and significantly improve memory,attention and logical thinking ability.The comprehensive intervention effect is superior to simple routine management. 展开更多
关键词 Continuous Positive Airway Pressure Obstructive Sleep Apnea-Hypopnea Syndrome Daytime Sleepiness Cognitive Function Sleep Quality
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Comparative efficacy of various exercise interventions on cognitive function in patients with mild cognitive impairment or dementia:A systematic review and network meta-analysis 认领 引用 被引量：76
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作者 Xiuxiu Huang Xiaoyan Zhao +4 位作者 Bei Li Ying Cai Shifang Zhang Qiaoqin Wan Fang Yu 《Journal of Sport and Health Science》 SCIE CAS CSCD 2022年第2期212-223,共12页
Background:Exercise is a promising nonpharmacological therapy for cognitive dysfunction,but it is unclear which type of exercise is most effective.The objective of this study was to compare and rank the effectiveness ... Background:Exercise is a promising nonpharmacological therapy for cognitive dysfunction,but it is unclear which type of exercise is most effective.The objective of this study was to compare and rank the effectiveness of various exercise interventions on cognitive function in patients with mild cognitive impairment(MCI)or dementia and to examine the effects of exercise on the symptoms relevant to cognitive impairment.Methods:We searched PubMed,Web of Science,Embase,Cochrane Central Register of Controlled Trials,SPORTDiscus,and PsycInfo through September 2019 and included randomized controlled trials that examined the effectiveness of exercise interventions in patients with MCI or dementia.Primary outcomes included global cognition,executive cognition,and memory cognition.Secondary outcomes included activities of daily living,neuropsychiatric symptoms,and quality of life.Pairwise analyses and network meta-analyses were performed using a random effects model.Results:A total of 73 articles from 71 trials with 5606 participants were included.All types of exercise were effective in increasing or maintaining global cognition,and resistance exercise had the highest probability of being the most effective intervention in slowing the decrease in global cognition(standard mean difference(SMD)=1.05,95%confidence interval(95%CI):0.56-1.54),executive function(SMD=0.85,95%CI:0.21-1.49),and memory function(SMD=0.32,95%CI:0.01-0.63)in patients with cognitive dysfunction.Subgroup analyses for patients with MCI revealed different effects,and multicomponent exercise was most likely to be the optimal exercise therapy for preventing the decline of global cognition(SMD=0.99,95%CI:0.44-1.54)and executive function(SMD=0.72,95%CI:0.06-1.38).However,only resistance exercise showed significant effects on memory function for patients with MCI(SMD=0.35,95%CI:0.01-0.69).Exercise interventions also showed various effects on the secondary outcomes.Conclusion:Resistance exercise has the highest probability of being the optimal exercise type for slowing cognitive declin e in patients withcognitive dysfunction,especially in patients with dementia.Multicomponent exercise tends to be most effective in protecting global cognition and executive function in patients with MCI. 展开更多
关键词 Cognitive function Cognitive impairment Exercise Network meta-analysis
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Comprehensive Management of Daily Living Activities,behavioral and Psychological Symptoms,and Cognitive Function in Patients with Alzheimer's Disease:A Chinese Consensus on Alzheimer's Disease 认领 引用 被引量：19
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作者 Jianjun Jia Jun Xu +9 位作者 Jun Liu Yongjun Wang Yanjiang Wang Yunpeng Cao Qihao Guo Qiuming Qu Cuibai Wei Wenshi Wei Junjian Zhang Enyan Yu 《Neuroscience Bulletin》 SCIE CAS CSCD 2021年第7期1025-1038,共14页
Alzheimer's disease(AD)is the most common cognitive disorder in the elderly.Its main clinical manifestations are cognitive decline(C),behavioral and psychological symptoms(B),and a decline in the activities of dai... Alzheimer's disease(AD)is the most common cognitive disorder in the elderly.Its main clinical manifestations are cognitive decline(C),behavioral and psychological symptoms(B),and a decline in the activities of daily living(A),also known as ABC symptoms.Early identification and evaluation of ABC symptoms are helpful for establishing the accurate diagnosis,comprehensive treatment,and prognosis of AD.To guide Chinese clinical practice for optimization of the comprehensive management of AD,in 2018,The Academy of Cognitive Disorder of China gathered 22 neurologists and gerontologists in China to build a consensus on the comprehensive management of AD.Based on a review of the evidence,the consensus summarizes the pathogenesis,pathological changes,clinical manifestations,evaluation,diagnosis,drug and non-drug treatment,and patient care for AD.Focus group discussion was used to establish a flowchart of comprehensive ABC management for AD patients.The new consensus provides a feasible AD management process for clinicians. 展开更多
关键词 Alzheimer’s disease Comprehensive management Activities of daily living Behavioral and psychological symptoms Cognitive function
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