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Efficacy and safety of integrative and complementary treatments versus conventional therapies in patients with vitiligo:A systematic review 认领 引用
1
作者 Juan Pablo Alzate-Granados Andrea Carolina Díaz-Manrique +4 位作者 Alexandra Maffiold-Novoa Leidy Vanessa Rodríguez-Moreano Yinneth Ruiz-Atencio Andrés Felipe Torres-Medina Vanessa Díaz-Granados 《Journal of Dermatologic Science and Cosmetic Technology》 2026年第2期1-8,共8页
Background:Vitiligo is a chronic depigmenting disorder with substantial psychosocial burden.Conventional therapies(topical corticosteroids,calcineurin inhibitors,phototherapy)have variable efficacy and tolerability,pr... Background:Vitiligo is a chronic depigmenting disorder with substantial psychosocial burden.Conventional therapies(topical corticosteroids,calcineurin inhibitors,phototherapy)have variable efficacy and tolerability,prompting growing interest in integrative and complementary treatments(ICTs).Objective:To synthesize evidence on the efficacy and safety of ICTs compared with conventional therapies in vitiligo and to outline their potential role,advantages,and limitations in clinical decision-making.Data Sources and Study Eligibility:We systematically searched MEDLINE(PubMed),Embase,CENTRAL,LILACS,and the ICTRP and ClinicalTrials.gov trial registries from inception to the review date for randomized and quasiexperimental comparative studies evaluating ICTs(e.g.,botanicals,fire needle therapy,microneedling-assisted drug delivery)versus conventional topical treatments or placebo in patients with vitiligo.Methods:Two reviewers independently screened records,selected studies,extracted data,and assessed risk of bias using the Cochrane RoB 2 tool.When at least two clinically and methodologically similar trials reported comparable dichotomous outcomes,we pooled effect estimates using random-effects meta-analysis and expressed results as risk ratios(RRs)with 95%confidence intervals(CIs).Results:Six randomized controlled trials(total n=255)met inclusion criteria;no eligible quasi-experimental or observational comparative studies were identified.Interventions included topical turmeric cream,oral Ginkgo biloba,fire needle therapy alone or combined with tacrolimus,microneedling-assisted delivery of calcipotriol plus betamethasone versus tacrolimus,and the traditional Chinese formulation Zengse Pill.Across individual trials,several ICTs achieved statistically significant improvements in repigmentation,lesion area reduction,or disease arrest compared with placebo or active comparators.Three studies were judged at overall low risk of bias and three had some concerns,mainly regarding allocation concealment and blinding.An exploratory metaanalysis of two trials(Zengse Pill and Ginkgo biloba)yielded a nonsignificant pooled RR of 2.05(95%CI 0.79–5.35;I2=52.6%),reflecting imprecision and moderate heterogeneity.Adverse events were generally mild and manageable(local irritation,transient erythema/itching,occasional mild nausea),and no serious treatmentrelated events were reported.Limitations:The evidence base is constrained by small sample sizes,short follow-up,heterogeneity of ICT protocols and outcome measures,incomplete reporting of key determinants such as Fitzpatrick phototype,and potential confounding by ambient ultraviolet exposure in predominantly tropical or subtropical study settings.Conclusions:Current data suggest that selected ICTs may serve as well-tolerated adjunctive options for patients with vitiligo,particularly when conventional therapies are insufficient or poorly tolerated.However,the certainty of benefit remains low due to methodological limitations and heterogeneity.Larger,multicenter randomized trials with longer follow-up and standardized outcome sets are needed before ICTs can be routinely integrated into vitiligo treatment algorithms. 展开更多
关键词 Vitiligo Complementary therapies Integrative medicine Microneedling Repigmentation Safety Randomized trials
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Effects of Complementary Acupuncture Points on the Expression of 5-HT and Its Receptors in the Acupoint Area and Hippocampal Tissue of Rats with Insomnia 认领 引用
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作者 Yue PANG Xingjie WANG +3 位作者 Xue LIU Taotao CUI Kunpeng XIA Zhixin YANG 《Medicinal Plant》 2026年第3期70-74,82,共5页
[Objectives]To investigate the effects of acupuncture at the complementary acupuncture points Neiguan and Waiguan on the expression levels of 5-HT,5-HIAA,5-HT 1A R,and 5-HT 4R within the acupoint area and hippocampal ... [Objectives]To investigate the effects of acupuncture at the complementary acupuncture points Neiguan and Waiguan on the expression levels of 5-HT,5-HIAA,5-HT 1A R,and 5-HT 4R within the acupoint area and hippocampal tissue of insomnic rats.[Methods]72 Wistar rats were randomly divided into the following groups,each comprising 12 animals:the complementary acupuncture point groups(through-acupuncture group,anti-acupuncture group),the single acupoint groups(Neiguan acupoint group,Waiguan acupoint group),the model group,and the blank group.The insomnia rat model was established through intraperitoneal injection of chlorobenzene alanine.Each acupuncture group underwent electroacupuncture treatment following the attainment of the deqi sensation,administered once daily for 20 min per session over a period of consecutive 6 d.Electroacupuncture was administered using dilatational waves,with a stimulation frequency alternating between 2 and 100 Hz,and a current intensity of 1 mA.The contents of 5-HT and 5-HIAA were detected by ELISA;5-HT 1A R levels were assessed using immunohistochemistry,and 5-HT 4R mRNA expression was evaluated through fluorescent in situ hybridization.[Results]Compared to the blank group,the expressions of 5-HT,5-HIAA,5-HT 1A R,and 5-HT 4R mRNA in both the acupoint area and hippocampal tissue of rats in the model group were significantly reduced(P<0.05).These indicators were significantly elevated in all acupuncture groups relative to the model group(P<0.05).Furthermore,the complementary acupuncture point groups(through-acupuncture and anti-acupuncture groups)demonstrated a more pronounced increase compared to the single acupoint groups(P<0.05).No statistically significant differences were observed between the through-acupuncture and anti-acupuncture groups,nor between the single Neiguan and Waiguan acupoint groups(P<0.05).[Conclusions]Acupuncture at the Neiguan and Waiguan acupoints effectively ameliorates insomnia in PCPA-treated rats.This therapeutic effect may be associated with increased expression levels of 5-HT,5-HIAA,5-HT 1A R,and 5-HT 4R mRNA in both the acupoint area and the central hippocampal tissue. 展开更多
关键词 Complementary acupuncture point Insomnia 5-HT 5-HIAA 5-HT 1A R 5-HT 4R
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Complementary inverter based on ZnO thin-film transistors 认领 引用 被引量：2
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作者 Dunan Hu Genyuan Yu +2 位作者 Ruqi Yang Honglie Lin Jianguo Lu 《Journal of Semiconductors》 EI CAS CSCD 2025年第6期106-110,共5页
Complementary inverter is the basic unit for logic circuits,but the inverters based on full oxide thin-film transistors(TFTs)are still very limited.The next challenge is to realize complementary inverters using homoge... Complementary inverter is the basic unit for logic circuits,but the inverters based on full oxide thin-film transistors(TFTs)are still very limited.The next challenge is to realize complementary inverters using homogeneous oxide semiconduc-tors.Herein,we propose the design of complementary inverter based on full ZnO TFTs.Li-N dual-doped ZnO(ZnO:(Li,N))acts as the p-type channel and Al-doped ZnO(ZnO:Al)serves as the n-type channel for fabrication of TFTs,and then the complemen-tary inverter is produced with p-and n-type ZnO TFTs.The homogeneous ZnO-based complementary inverter has typical volt-age transfer characteristics with the voltage gain of 13.34 at the supply voltage of 40 V.This work may open the door for the development of oxide complementary inverters for logic circuits. 展开更多
关键词 complementary inverter thin-film transistor ZnO n-type channel p-type channel
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Analysis of Renewable Energy Absorption and Economic Feasibility in Multi-Energy Complementary Systems under Spot Market Conditions 认领 引用 被引量：1
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作者 Xiuyun Wang Zipeng Zhang +1 位作者 Chuang Liu Guoliang Bian 《Energy Engineering》 EI 2025年第2期577-619,共43页
As the power system transitions to a new green and low-carbon paradigm,the penetration of renewable energy in China’s power system is gradually increasing.However,the variability and uncertainty of renewable energy o... As the power system transitions to a new green and low-carbon paradigm,the penetration of renewable energy in China’s power system is gradually increasing.However,the variability and uncertainty of renewable energy output limit its profitability in the electricity market and hinder its market-based integration.This paper first constructs a wind-solar-thermalmulti-energy complementary system,analyzes its external game relationships,and develops a bi-level market optimization model.Then,it considers the contribution levels of internal participants to establish a comprehensive internal distribution evaluation index system.Finally,simulation studies using the IEEE 30-bus system demonstrate that the multi-energy complementary system stabilizes nodal outputs,enhances the profitability of market participants,and promotes the market-based integration of renewable energy. 展开更多
关键词 Multi-energy complementary systems spot market two-layer optimization new energy consumption
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Radar pulse waveform design method based on complementary amplitude coding 认领 引用
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作者 XIE Ailun LIU Xiaobin +3 位作者 WU Qihua ZHAO Feng QIAO Zhenyu XIAO Shunping 《Journal of Systems Engineering and Electronics》 SCIE CSCD 2025年第3期671-680,共10页
Low sidelobe waveform can reduce mutual masking between targets and increase the detection probability of weak targets.A low sidelobe waveform design method based on complementary amplitude coding(CAC)is proposed in t... Low sidelobe waveform can reduce mutual masking between targets and increase the detection probability of weak targets.A low sidelobe waveform design method based on complementary amplitude coding(CAC)is proposed in this paper,which can be used to reduce the sidelobe level of multiple waveforms.First,the CAC model is constructed.Then,the waveform design problem is transformed into a nonlinear optimization problem by constructing an objective function using the two indicators of peak-to-sidelobe ratio(PSLR)and integrated sidelobe ratio(ISLR).Finally,genetic algorithm(GA)is used to solve the optimization problem to get the best CAC waveforms.Simulations and experiments are conducted to verify the effectiveness of the proposed method. 展开更多
关键词 waveform design low sidelobe complementary amplitude coding(CAC) genetic algorithm(GA)
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The Study of Long-Term Trading Revenue Distribution Models in Wind-Photovoltaic-Thermal Complementary Systems Based on the Improved Shapley Value Method 认领 引用
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作者 Dongfeng Yang Ruirui Zhang +1 位作者 Chuang Liu Guoiang Bian 《Energy Engineering》 EI 2025年第7期2673-2694,共22页
Under the current long-term electricity market mechanism,new energy and thermal power face issues such as deviation assessment and compression of generation space.The profitability of market players is limited.Simulta... Under the current long-term electricity market mechanism,new energy and thermal power face issues such as deviation assessment and compression of generation space.The profitability of market players is limited.Simultaneously,the cooperation model among various energy sources will have a direct impact on the alliance’s revenue and the equity of income distribution within the alliance.Therefore,integrating new energy with thermal power units into an integrated multi-energy complementary system to participate in the long-term electricity market holds significant potential.To simulate and evaluate the benefits and internal distribution methods of a multi-energy complementary system participating in long-term market transactions,this paper first constructs a multi-energy complementary system integrated with new energy and thermal power generation units at the same connection point,and participates in the annual bilateral game as a unified market entity to obtain the revenue value under the annual bilateral market.Secondly,based on the entropy weight method,improvements are made to the traditional Shapley value distribution model,and an internal distribution model for multi-energy complementary systems with multiple participants is constructed.Finally,a Markov Decision Process(MDP)evaluation system is constructed for practical case verification.The research results show that the improved Shapley value distribution model achieves higher satisfaction,providing a reasonable allocation scheme for multi-energy complementary cooperation models. 展开更多
关键词 Multi-energy complementary system cooperative game enhancements to the Shapley value MDP indicators
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Complementary enhancement between noble metal-like Fe3C and Cu0/Cu+sites to fulfil highly selective wide-potential nitrate electroreduction to ammonia 认领 引用 被引量：1
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作者 Yuxuan Zhou Runlin Xia +4 位作者 Ran Hao Shengjing Li Xinyu Chen Yuping Liu Wei Li 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2025年第9期713-723,I0019,共11页
Mild electrocatalytic nitrate reduction reaction(NO3RR),driven by renewable electricity,is regarded as a desirable strategy for green ammonia synthesis and simultaneous removal of nitrogen-containing environmental ... Mild electrocatalytic nitrate reduction reaction(NO3RR),driven by renewable electricity,is regarded as a desirable strategy for green ammonia synthesis and simultaneous removal of nitrogen-containing environmental pollutants.In view of different supply voltages from renewable energy sources,developing costeffective and efficient electrocatalysts with a wide operating potential window is very meaningful for practical application.However,currently reported catalysts usually need to introduce noble metals to synergistically achieve wide-potential selective ammonia synthesis from nitrate.In this work,we present for the first time a dual-transition-metal electrocatalyst(Fe3C-CuOx@NC,x=0,1)with wide-potential-adaptability for highly selective nitrate reduction to ammonia.Such Fe3C-CuOx@NC with spatially separated CuOxand noblemetal-like Fe3C nanoparticles encapsulated with nitrogen-doped graphitized carbon,exhibits outstanding performance in NO3RR with desirable NH3Faraday efficiency of more than 90%over a wide potential ranging from-0.2 V vs.RHE to-0.6 V vs.RHE,comparable to the reported noble metal catalysts.Different from common tandem catalysis,the wide-potential high ammonia selectivity of Fe3C-CuOx@NC is domina ntly ascribed to the complementary enhancement between CuOxand Fe3C,fully supported by results of experiments and density function theory calculations.CuOxexhibit highly intrinsic nitrate reduction to nitrite to compensate for the slow potential determination step(*NO3→*NO3H)of Fe3C,while Fe3C,besides behaving like noble metals to supply adequate active hydrogens,has both good adsorption and reduction abilities for nitrite species to ammonia.Moreover,Fe3C partially stabilizes active Cu0/Cu+sites,and the unique carbon-layer enca psulation structure effectively prevents the agglomeration and corrosion of metal nanoparticles during the electrocatalysis,thus maintaining good cyclic stability.The Zn-NO3-battery assembled with Fe3C-CuOx@NC can reach a high power density of 5.2 mW cm-2at a potential of 1.0 V vs.Zn,with an NH3Faraday efficiency of 92.4%at a current of 8.0 mA,proving its potential practical application.This advance provides unique insights into complementary catalysis mechanisms on multiple metal sites in NO3RR,and offers a reference for the design of other transition metal electrocatalysts matching with renewable electricity. 展开更多
关键词 Nitrate reduction reaction Ammonia synthesis Wide potential window Complementary enhancement
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Prevalence and patterns of complementary and alternative medicine usage among adults with chronic kidney disease:A systematic review and meta-analysis 认领 引用
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作者 Jia Wen Chin Rafidah Abdullah +2 位作者 Benjamin Wei Wang Tan Koh Wei Wong Ban-Hock Khor 《Journal of Integrative Medicine》 SCIE CAS CSCD 2025年第4期370-381,共12页
Background:The use of complementary and alternative medicine(CAM)is common among individuals with underlying chronic illnesses.Objective:This systematic review and meta-analysis investigated the global prevalence and ... Background:The use of complementary and alternative medicine(CAM)is common among individuals with underlying chronic illnesses.Objective:This systematic review and meta-analysis investigated the global prevalence and patterns of CAM use among individuals with chronic kidney disease(CKD).Search strategy:PubMed,Embase,and Cumulative Index to Nursing and Allied Health Literature Plus were searched from inception until 26th February 2024.Inclusion criteria:Original articles reporting the use of at least one type of CAM among individuals aged above 18 years old and at all stages of CKD or undergoing any form of kidney replacement therapy.Data extraction and analysis:Two independent reviewers performed the literature screening.The data were extracted from the included studies by one reviewer and cross-checked by another.Discrepancies were resolved by discussion and consensus among two reviewers.Primary information included prevalence of CAM use,types of CAM used,reasons for CAM use,factors associated with CAM use,and disclosure to healthcare providers.Meta-analyses were performed to determine the pooled prevalence of CAM use and non-disclosure of CAM using a random effect model.Results:Forty-one studies were included in this systematic review and meta-analysis.The pooled prevalence of CAM use was 43%(95%confidence interval:34%,51%),I2=99.46%.The reasons for CAM use included treatment of underlying comorbidities,complications or symptoms,maintenance of general health,and treatment of CKD.Nutritional approaches were the most common CAM modality,with 412different herbal and dietary supplements reported;psychological and physical approaches included massage therapy,relaxation techniques,and mind–body practices;and other complementary health approaches such as homeopathy,traditional Chinese medicine,and Ayurvedic medicine were also frequently reported.Factors associated with CAM use included sociodemographic characteristics such as older age,female gender,or higher income;disease or therapy factors such as not having diabetes,relying on hemodialysis,or poor adherence to medication;and patient or internal factors such as positive attitude towards CAM and perceived safety of CAM.About 66%(61%,72%)of CAM users did not disclose the use of CAM to their healthcare providers.Conclusion:CAM use is prevalent among individuals with CKD,and healthcare providers should communicate openly and effectively to emphasize the rational use of CAM to avoid potential harm. 展开更多
关键词 Complementary and alternative medicine Traditional medicine Chronic kidney disease Systematic review Meta-analysis
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Complementary medicines and ginseng for inflammatory bowel disease-rooted in science,but will it bear fruit? 认领 引用
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作者 Tamar Schildkraut Ashish R Srinivasan +2 位作者 Andrew Nguyen Mark Lai Abhinav Vasudevan 《World Journal of Gastroenterology》 SCIE CAS 2025年第27期1-14,共14页
This editorial is based on the network pharmacology and in vivo study by Qin et al,which investigated the potential therapeutic mechanisms of Panax ginseng(P.ginseng)in ulcerative colitis.The key findings from the stu... This editorial is based on the network pharmacology and in vivo study by Qin et al,which investigated the potential therapeutic mechanisms of Panax ginseng(P.ginseng)in ulcerative colitis.The key findings from the study included the identification of the targets of P.ginseng and ulcerative colitis,elucidation of mechanistic pathways,and in vivo validation of the pharmacological activity and therapeutic effect of panaxadiol,a key active component of P.ginseng.This editorial provides additional context regarding the evidence supporting the use of ginseng and other commonly used complementary therapies that clinicians may encounter.We also aim to highlight potential similarities between the mechanisms of popular complementary and conventional medical therapies. 展开更多
关键词 Inflammatory bowel disease Crohn’s disease Ulcerative colitis Ginseng Complementary and alternative therapies
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Utilizing complementary therapy to enhance quality of life and reduce stress and fatigue in pediatric cancer patients 认领 引用
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作者 Luis Carlos Lopes-Júnior Regina Aparecida Garcia de Lima 《World Journal of Clinical Cases》 2025年第11期12-18,共7页
The international scientific literature presents still incipient results regarding the management of cancer symptom clusters by oncology nursing,especially in pediatric oncology.This is a promising field of investigat... The international scientific literature presents still incipient results regarding the management of cancer symptom clusters by oncology nursing,especially in pediatric oncology.This is a promising field of investigation for clinical nurses and researchers,and when it is subsidized by medium-range theories,they co-rroborate the diagnoses and interventions of nursing in oncology,enhancing the science of nursing care.This minireview article aims to discuss the utilizing the hospital clowns as a complementary therapy,to enhance quality of life and reduce stress and fatigue in pediatric cancer patients.Overall,the evidence presented so far pointed out that complementary therapy might help improve the quality of life of pediatric cancer patients,and that complementary therapy usage should be part of a health comprehensive care model,delivering therapeutic approaches that might enhance the mind-body during a pediatric cancer patients’life span.The results of scientific investigations by nurses,particularly those linked to the basic sciences,play a critical role in advancing personalized care in pediatric integrative oncology. 展开更多
关键词 Cancer symptom clusters Pediatrics Pediatric cancer patients Pediatric integrative oncology Complementary therapies Oncology nursing Hospital clowns Cancer-related fatigue Psychological stress Biomarkers
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Skeleton-Silhouette Complementary Perception: Toward Robust Gait Recognition 认领 引用
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作者 Xiaokai Liu Luyuan Hao 《Journal of Clinical and Nursing Research》 2025年第11期372-377,共6页
Gait,the unique pattern of how a person walks,has emerged as one of the most promising biometric features in modern intelligent sensing.Unlike fingerprints or facial characteristics,gait can be captured unobtrusively ... Gait,the unique pattern of how a person walks,has emerged as one of the most promising biometric features in modern intelligent sensing.Unlike fingerprints or facial characteristics,gait can be captured unobtrusively and at a distance,without requiring the subject’s awareness or cooperation.This makes it highly suitable for long-range surveillance,forensic investigation,and smart environments where contactless recognition is crucial.Traditional gait-recognition systems rely either on silhouettes,which capture the outer appearance of a person,or on skeletons,which describe the internal structure of human motion.Each modality provides only a partial understanding of gait.Silhouettes emphasize shape and contour but are easily distorted by clothing or carried objects;skeletons describe motion dynamics and limb coordination but lose discriminative details about body shape.This article presents the concept of Complementary Semantic Embedding(CSE),a unified framework that merges silhouette and skeleton information into a comprehensive semantic representation of human walking.By modeling the complementary nature of appearance and structure,the approach achieves more robust and accurate gait recognition even under challenging conditions. 展开更多
关键词 Complementary perception Gait recognition Feature fusion
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The Existence of the Solution for Linear Complementary Problem 认领 引用
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作者 寇述舜 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 1995年第7期683-685,共3页
This paper deals with the existince of the solulionlor linear complementaryproblern. The uniqueness theorem of lhe solution for linear compiementary. problem isproved. Two evaniples are given. They show that “M is po... This paper deals with the existince of the solulionlor linear complementaryproblern. The uniqueness theorem of lhe solution for linear compiementary. problem isproved. Two evaniples are given. They show that “M is positive .sermidefinite”neither sufficient nor necessary codition .for te, existence to the solution of linearcomplementary. problem. 展开更多
关键词 linear complementary problem complementary basic feasiblesolution existence. Lemke's complementary pivoting algorithm
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Complementary and alternative medicine use in Iranian patients with diabetes mellitus 认领 引用 被引量：10
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作者 Mohammad Hashem Hashempur Mojtaba Heydari +2 位作者 Seyed Hamdollah Mosavat Seyyed Taghi Heydari Mesbah Shams 《Journal of Integrative Medicine》 CAS CSCD 2015年第5期319-325,共7页
OBJECTIVE： There is increasing interest in complementary and alternative medicine generally, and especially by those affected by chronic diseases, such as diabetes mellitus. We aimed to determine the prevalence and p... OBJECTIVE： There is increasing interest in complementary and alternative medicine generally, and especially by those affected by chronic diseases, such as diabetes mellitus. We aimed to determine the prevalence and pattern of complementary and altemative medicine use among patients suffering from diabetes mellitus in Shiraz, southern Iran. Another objective was to explore associated factors for use of complementary and alternative medicine among patients with diabetes mellitus. METHODS： A 19-item semi-structured questionnaire （open- and close-ended） was administered to 239 patients with diabetes mellitus in this cross-sectional study. It was carried out in two outpatient diabetes clinics affiliated with the Shiraz University of Medical Sciences, Shiraz, Iran. RESULTS： One hundred and eighty patients （75.3%） used at least one type of complementary and alternative medicine in the last year prior to the interview. Patients with diabetes mellitus who were living in a large family （〉 5 members）, not taking insulin, and believed that complementary and alternative medicine have synergistic effects with conventional medicine, were independently and significantly （P values： 0.02, 0.04, and 0.01, respectively） more likely to use complementary and alternative medicine. Most of the users （97.7%） reported use of herbal preparations, and 89.4% of users did not change their medication, neither in medication schedule nor its dosage. CONCLUSION： The use of complementary and alternative medicine, especially herbal remedies, is popular among diabetes patients in Shiraz, Iran. This use is associated with patients＇ family size, type of conventional medications and their view about concomitant use of complementary and conventional medicine. 展开更多
关键词 diabetes mellitus complementary therapies prevalence medicine, herbal Iran.
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Complementary and alternative medicine on cognitive defects and neuroinflammation after sepsis 认领 引用 被引量：5
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作者 LI Zhenxuan WANG Xuerui +4 位作者 Luis Ulloa Ayman Youssef BAI Yunjing XU Xiaolong LIU Qingquan 《Journal of Traditional Chinese Medicine》 SCIE CSCD 2024年第2期408-416,共9页
Sepsis-associated encephalopathy(SAE)is a common manifestation of sepsis,ranging from mild confusion and delirium to severe cognitive impairment and deep coma.SAE is associated with higher mortality and long-term outc... Sepsis-associated encephalopathy(SAE)is a common manifestation of sepsis,ranging from mild confusion and delirium to severe cognitive impairment and deep coma.SAE is associated with higher mortality and long-term outcomes,particularly substantial declines in cognitive function.The mechanisms of SAE probably include neuroinflammation that is mediated by systemic inflammation and ischemic lesions in the brain,a disrupted blood–brain barrier,oxidative stress,neurotransmitter dysfunction,and severe microglial activation.Increasing evidence suggests that complementary and alternative medicine,especially Traditional Chinese Medicine(TCM),is favorable in alleviating cognitive decline after sepsis.Here,we summarized the studies of traditional herbal remedies,TCM formulas and acupuncture therapy in animal models of neurological dysfunctions after sepsis in recent decades and reviewed their potential mechanisms. 展开更多
关键词 sepsis-associated encephalopathy cognitive dysfunction complementary therapies neuroinflammatory diseases medicine Chinese traditional review
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Effects of Nutrient Fortified Complementary Food Supplements on Anemia of Infants and Young Children in Poor Rural of Gansu 认领 引用 被引量：6
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作者 YU-YING WANG CHUN-MING CHEN +2 位作者 FU-ZHEN WANG MEI JIA KE-AN WANG 《Biomedical and Environmental Sciences》 SCIE CAS 2009年第3期194-200,共7页
Objective To assess the effectiveness of complementary food supplements with protein and multi-micronutrients on hemoglobin and anemia in infants and young children. Methods In 5 poor counties of Gansu, 984 children a... Objective To assess the effectiveness of complementary food supplements with protein and multi-micronutrients on hemoglobin and anemia in infants and young children. Methods In 5 poor counties of Gansu, 984 children aged 6-12 months were enrolled and divided into two groups. In addition to the usual home-made complementary food, all the children were fed one sachet of either Formula Ⅰ or Formula Ⅱ supplements each day. Protein and micronutrients were provided in Formula Ⅰ, while the same energy intake was secured in Formula Ⅱ as in Formula Ⅰ. A massive dose of vitamin A was supplemented to all the children every 6 months. Hemoglobin test was done at the same time. Results Prevalence of anemia was about 35% in both Formula Ⅰ and Formula Ⅱ group at baseline, and there were no differences in hemoglobin concentration between the two groups, During the 6-month and 12-month supplementation, hemoglobin of children in Formula Ⅰ group was higher than that in Formula Ⅱ group （P〈0.05）, and hemoglobin increase in Formula Ⅰ group was significantly higher than that in Formula Ⅱ group （P〈0.001）. After 6- and 12-mouth supplementation, the prevalence of anemia in Formula Ⅰ group dropped to 19.1% and 8.2% respectively, and it was 28.0% and 12.4% in Formula 2 group. The prevalence of anemia in Formula Ⅰ group was significantly lower than that in Formula Ⅱ group （P〈0.05）. After adjusting age and hemoglobin level at baseline, the hemoglobin increase at age of 24 months in formula 1 group was higher （10.7 g/L vs 7.9 g/L, P〈0.0001）. Conclusion Micronutrient fortified complementary food supplements, with large-dose vitamin A, is effective for children aged 6-12 months in terms of iron deficiency prevention. 展开更多
关键词 Food fortification Complementary food supplements Infants and young children Hemoglobin Iron deficiency anemia
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Doctor communication quality and Friends' attitudes influence complementary medicine use in inflammatory bowel disease 认领 引用 被引量：6
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作者 Réme Mountifield Jane M Andrews +1 位作者 Antonina Mikocka-Walus Peter Bampton 《World Journal of Gastroenterology》 SCIE CAS 2015年第12期3663-3670,共8页
AIM: To examine the frequency of regular complementary and alternative therapy(CAM) use in three Australian cohorts of contrasting care setting and geography, and identify independent attitudinal and psychological pre... AIM: To examine the frequency of regular complementary and alternative therapy(CAM) use in three Australian cohorts of contrasting care setting and geography, and identify independent attitudinal and psychological predictors of CAM use across all cohorts. METHODS: A cross sectional questionnaire was administered to inflammatory bowel disease(IBD) patients in 3 separate cohorts which differed by geographical region and care setting. Demographics and frequency of regular CAM use were assessed, along with attitudes towards IBD medication and psychological parameters such as anxiety, depression, personality traits and quality of life(QOL), and compared across cohorts. Independent attitudinal and psychological predictors of CAM use were determined using binary logistic regression analysis. RESULTS: In 473 respondents(mean age 50.3 years, 60.2% female) regular CAM use was reported by45.4%, and did not vary between cohorts. Only 54.1%of users disclosed CAM use to their doctor. Independent predictors of CAM use which confirm those reported previously were: covert conventional medication dose reduction(P < 0.001), seeking psychological treatment(P < 0.001), adverse effects of conventional medication(P = 0.043), and higher QOL(P < 0.001).Newly identified predictors were CAM use by family or friends(P < 0.001), dissatisfaction with patient-doctor communication(P < 0.001), and lower depression scores(P < 0.001). CONCLUSION: In addition to previously identified predictors of CAM use, these data show that physician attention to communication and the patient-doctor relationship is important as these factors influence CAM use. Patient reluctance to discuss CAM with physicians may promote greater reliance on social contacts to influence CAM decisions. 展开更多
关键词 Complementary medicine Alternative therapy Therapy
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The knowledge, attitude, practice and predictors of complementary and alternative medicine use among type 2 diabetes mellitus patients in Indonesia 认领 引用 被引量：5
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作者 Yunita Sari Akhyarul Anam +1 位作者 Annas Sumeru Eman Sutrisna 《Journal of Integrative Medicine》 SCIE CAS CSCD 2021年第4期347-353,共7页
Objective: The prevalence of complementary and alternative medicine(CAM) usage among patients with type 2 diabetes mellitus(T2DM) in Indonesia is high. However, to date, little is known about why Indonesian T2DM patie... Objective: The prevalence of complementary and alternative medicine(CAM) usage among patients with type 2 diabetes mellitus(T2DM) in Indonesia is high. However, to date, little is known about why Indonesian T2DM patients choose CAM therapies, how their knowledge, attitude and practice(KAP) of CAM affects their choices, or how demographics correlate with patient choices. Therefore, this study aimed to investigate the KAP and predictors of CAM usage in T2DM patients in Indonesia.Methods: This was an observational, cross-sectional study. Patients were interviewed using a questionnaire. Chi-square tests or Fisher’s exact tests were used to compare demographic and clinical data, as well as KAP assessments, between T2DM patients who use and do not use CAM. Multivariate logistic regression analyses were used to investigate predictors of CAM usage.Results: A total of 628 T2DM patients were enrolled in the study. CAM therapies were used by 341 patients(54.3%). The most common therapies were herbs and spiritual healing, used by 100.0% and 68.3% of CAM-using patients, respectively. CAM therapies were frequently recommended by family members(91.5%), and CAM users had significantly more knowledge and more positive attitudes toward CAM therapies than nonusers. Among users, 66% said they would not follow their healthcare providers’ instructions to not use CAM therapies, and 69.5% said they would not disclose their plan to use CAM therapies with their healthcare provider. Neither demographic nor clinical characteristics were associated with CAM use. The factors that best predicted the use of CAM therapies were their availability and low cost(odds ratio [OR] = 4.59;95% confidence interval [CI]: 3.01–7.01), the belief that CAM therapies were safe(OR = 2.04;95% CI: 1.40–2.95), the belief that CAM therapies could help with diabetes control(OR = 1.75;95% CI: 1.15–2.66), and the belief that CAM therapies could help maintain physical health(OR = 1.68;95% CI: 1.13–2.49).Conclusion: CAM therapy users were more knowledgeable and had more positive attitudes toward CAM,but most of them chose not to disclose their CAM use to their healthcare providers. CAM use in Indonesia was associated with its accessibility, affordability, safety and effectivity, but not with any demographic or clinical characteristics. This study provided new evidence and insights for nurses and physicians in Indonesia that will help to design educational programs about the safety and efficacy of CAM therapies. 展开更多
关键词 Attitude Complementary and alternative medicine Diabetes mellitus Knowledge Practice Predictors
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Label-free visualization of lignin deposition in loquats using complementary stimulated and spontaneous Raman microscopy 认领 引用 被引量：7
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作者 Nan Zhu Yifan Yang +2 位作者 Minbiao Ji Di Wu Kunsong Chen 《Horticulture Research》 SCIE 2019年第1期875-887,共13页
The lignification triggered by biotic or abiotic stresses hardens fruits and vegetables and eventually influences their consumer appeal.Extensive prior efforts have been made to unveil the underlying mechanism of fles... The lignification triggered by biotic or abiotic stresses hardens fruits and vegetables and eventually influences their consumer appeal.Extensive prior efforts have been made to unveil the underlying mechanism of flesh lignification,primarily focused on its physicochemical and molecular biological properties.Nevertheless,most of these studies used destroyed and homogenized bulk tissues as analytes;as a result,potentially valuable spatial information was lost.In this study,the deposition of lignin in loquat flesh during lignification was visualized from the tissue level to the singlecell level by combining the advantages of stimulated Raman scattering(SRS)and spontaneous Raman microscopy using label-free in situ molecular imaging.SRS has the advantages of being fast and providing large-area chemical imaging to reveal the spatial heterogeneity of lignin and cell wall polysaccharide distribution in loquat flesh.After 2 days of storage at 0℃,increased lignins were observed by large-area SRS imaging.In addition,microscopic SRS images of the flesh cells indicated that the increased lignins were trapped in the cell corner(CC)and middle lamella(ML).Furthermore,the compositional and structural features of lignified cells(LCs),CC and ML of loquat flesh were investigated by spontaneous Raman microscopy,and the results showed that the LCs were a combination of lignin,cellulose,and hemicellulose,whereas CC and ML showed only deposited lignin and pectin without cross-linked cellulose and hemicellulose.This result further suggests that the lignins in the CC and ML regions of loquats were later synthesized alone during postharvest storage.This innovative combination of SRS and spontaneous Raman microscopy allows the label-free macroscale and fine chemical imaging of plant cell walls and will enhance our fundamental understanding of the structures and functions of the plant cell wall. 展开更多
关键词 properties complementary eventually
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Consensus views on competencies and teaching methods for an interprofessional curriculum on complementary and integrative medicine:A Delphi study 认领 引用 被引量：4
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作者 Angelika Homberg Katja Krug +3 位作者 Nadja Klafke Katharina Glassen Cornelia Mahler Svetla Loukanova 《Journal of Integrative Medicine》 SCIE CAS CSCD 2021年第3期282-290,共9页
Objective:A collaborative team is necessary to help patients achieve their healthcare goals using complementary medicine.At present,healthcare professionals do not feel sufficiently qualified to provide this service.T... Objective:A collaborative team is necessary to help patients achieve their healthcare goals using complementary medicine.At present,healthcare professionals do not feel sufficiently qualified to provide this service.This study sought to identify competencies and teaching methods for interprofessional training on complementary and integrative medicine at medical schools.Methods:Sixty-five German-speaking experts with various professional backgrounds were invited to take part in a three-round Delphi study.In the first round,predefined competencies were assessed on a seven-point Likert scale,and participants were invited to propose additional competencies that would be evaluated in the subsequent rounds.The competencies were ranked based on the participant assessments and were assigned to four relevance groups.In the second and third rounds,suitable teaching methods were identified using free-text fields and multiple-choice questions.In a final workshop,participants synthesized the outcomes of the previous sessions and derived key competencies that would be a benefit to undergraduate interprofessional training in complementary and integrative medicine at medical schools.Results:The three rounds plus final worksop were attended by 50,40,36 and 11 experts.The competencies that these experts determined to be highly relevant to teaching complementary and integrative medicine emphasized,in particular,the respectful treatment of patients and the importance of taking a medical history.From these highly relevant competencies,three key targets were agreed upon in the final workshop:students are able to 1)classify and assess complementary medical terms and methods;2)work collaboratively and integrate patients into the interprofessional team;3)involve patients and their relatives respectfully and empathetically in all healthcare processes.To achieve these competency goals,the following teaching methods were highlighted:students discuss therapy options based on authentic patient cases with each other and practice empathic patient communication incorporating complementary medicine.Further,the theoretical background of complementary medicines could be provided as online-training,to use the class sessions for hands-on exercises and interprofessional exchange and discussion.Conclusion:Despite the heterogeneous panel of experts,a consensus was reached on the competency orientation and teaching approaches.The results can promote the implementation of interprofessional training for complementary medicine in undergraduate education. 展开更多
关键词 Undergraduate education Interprofessional education Complementary medicine Delphi study Curriculum Competency
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The necessity for integrating traditional, complementary, and alternative medicine into medical education curricula in Iran 认领 引用 被引量：3
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作者 Mohammad Hossein Ayati Ata Pourabbasi +4 位作者 Nazli Namazi Arman Zargaran Zahra Kheiry Amir Hooman Kazemi Bagher Larijani 《Journal of Integrative Medicine》 SCIE CAS CSCD 2019年第4期296-301,共6页
Background: The use of traditional and complementary medicine (T&CM) is increasing in both developed and developing countries. The school of Persian medicine (PM) in Iran is a comprehensive medical school that is ... Background: The use of traditional and complementary medicine (T&CM) is increasing in both developed and developing countries. The school of Persian medicine (PM) in Iran is a comprehensive medical school that is rich in history and has its own special principles, elements, philosophy, and diagnostic and treatment options. Many complementary therapy modalities are also popular and in demand among patients and physicians. The aim of this paper is to provide logic for the policymakers in Iranian medical education to make changes in medical education curricula, particularly on integrating T&CM. Methods: We reviewed the global experience in teaching T&CM to medical students, and highlighting the strengths of PM, described why it is necessary to integrate T&CM into general medicine curricula in Iran. Results: PM is a traditional system of medicine that dates back about 7000 years. Although there are few studies about the safety and effectiveness of PM, research into it has recently been accelerated. There is a suitable opportunity for integrating T&CM with conventional medicine. Physicians should be familiar with T&CM to avoid any contraindications, interactions, and unwanted effects. Conclusion: Traditional medicine is part of Iran's heritage and. thus, needs special attention. Familiarization of physicians with T&CM can help them choose the best treatment options for their patients. To integrate T&CM into the medical education curricula of Iran, a two-credit course has been proposed for implementation across the country. 展开更多
关键词 Integrative medicine Traditional medicine Complementary medicine Medical education curriculum
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