BACKGROUND Although numerous studies indicate that adverse mental states negatively affect sleep,few have systematically analyzed the association between various adverse mental states and insomnia.Furthermore,potentia...BACKGROUND Although numerous studies indicate that adverse mental states negatively affect sleep,few have systematically analyzed the association between various adverse mental states and insomnia.Furthermore,potential gender differences within such associations remain underexplored.AIM To investigate gender differences in correlations between adverse mental states and insomnia,and identify genderspecific risk factors for severe insomnia.METHODS A multicenter cross-sectional survey method was employed.A total of 2009 adult participants(2019-2021)completed an insomnia clinical assessment form.The form covered sociodemographic information,14 subjectively reported adverse mental states,core insomnia symptoms,and the Pittsburgh Sleep Quality Index.RESULTS Depression,apathy,fatigue,impatience-irritability,grief,forgetfulness,and slow response were significantly associated with insomnia.Timidity,indecision,suspiciousness,catatonia,decreased willpower,taciturnity,and inattention showed no significant association with insomnia.Grief(r=0.062,P<0.05),fatigue(r=0.065,P<0.05),and slow response(r=0.080,P<0.01)were correlated with increased time to fall asleep in women;no mental factors influencing sleep latency were identified in men.Apathy(r=0.073,P<0.05)was associated only with increased nocturnal awakenings in men,but not in women.Impatience-irritability was a risk factor for severe insomnia exclusively in men(odds ratio=1.62,95%CI:1.13-2.32,P=0.009),while grief was a risk factor specifically for women(odds ratio=1.83,95%CI:1.20-2.80,P=0.005).CONCLUSION Not all adverse mental states are significantly associated with insomnia,and the correlation between adverse mental states and insomnia varies according to gender and specific sleep dimensions.展开更多
Background:Benign prostatic hyperplasia(BPH)is prevalent among aging men.Whether exposure to internet-derived health information is associated with disease awareness and symptom burden at initial diagnosis remains unc...Background:Benign prostatic hyperplasia(BPH)is prevalent among aging men.Whether exposure to internet-derived health information is associated with disease awareness and symptom burden at initial diagnosis remains unclear.Methods:We conducted a cross-sectional study of 400 newly diagnosed BPH outpatients.Participants were classified by prior exposure to internet-derived BPH content.BPH awareness and International Prostate Symptom Scores(IPSS)were compared using the Mann-Whitney U test and multivariate linear regression adjusted for age,education,and disposable income.Stratified analyses were performed according to educational attainment,disposable income,and content format.Results:Exposure to internet-derived BPH content was independently associated with higher awareness and lower IPSS.Compared with unexposed participants,exposed participants had higher awareness(median 1.5 vs.0)and lower IPSS(median 7.0 vs.10.5)(both p<0.001).In multivariable models,being unexposed was associated with a 1.39-point lower awareness score and a 2.20-point higher IPSS(both p<0.001).In stratified analyses,the associations remained significant across education and income strata.Among exposed participants,those accessing text-based or mixed-format content had higher awareness and lower IPSS than those exposed to videos only(both p<0.001).Conclusions:This study shows that exposure to internet-derived health content is significantly associated with higher BPH awareness and a lower symptom burden at initial presentation.Text-based or mixed-format content may be more effective than video-only formats.展开更多
Objective:To investigate the prevalence of fatigue and identify its associated influencing factors in patients with inflammatory bowel disease(IBD),thereby providing an evidence base for targeted clinical intervention...Objective:To investigate the prevalence of fatigue and identify its associated influencing factors in patients with inflammatory bowel disease(IBD),thereby providing an evidence base for targeted clinical interventions.Methods:A cross-sectional survey design was adopted.A total of 204 patients with confirmed IBD diagnoses were consecutively enrolled from the gastroenterology outpatient clinics and inpatient wards of a tertiary-level hospital in Shiyan,Hubei Province,China,between June 2023 and June 2024.Fatigue was assessed using the IBD-Fatigue(IBD-F)scale.Sociodemographic characteristics,disease-related parameters,inflammatory biomarkers,and psychological status were simultaneously collected.Univariable analyses and multivariable logistic regression were performed to identify independent determinants of fatigue.Results:Among the 204 enrolled IBD patients,142(69.61%)had fatigue(IBD-F≥13).Univariable analyses revealed that sex,disease activity status,anemia,C-reactive protein(CRP)level,serum albumin level,sleep quality,anxiety,and depression were significantly associated with fatigue occurrence(all p<0.05).Multivariable logistic regression identified active disease phase(OR=3.12,95%CI:1.54–6.31,p=0.002),comorbid anemia(OR=2.87,95%CI:1.42–5.80,p=0.004),elevated CRP(OR=2.43,95%CI:1.21–4.88,p=0.013),poor sleep quality(OR=2.19,95%CI:1.10–4.36,p=0.026),and comorbid depression(OR=3.56,95%CI:1.76–7.19,p=0.001)as independent risk factors for fatigue;serum albumin≥35 g/L was identified as a protective factor(OR=0.48,95%CI:0.24–0.96,p=0.037).Fatigue was significantly and negatively correlated with health-related quality of life(r=−0.61,p<0.001).Conclusion:The prevalence of fatigue in IBD patients is as high as 69.61%,and it is independently associated with disease activity,elevated inflammatory markers,anemia,sleep disturbance,and depression,significantly impairing patients’quality of life.Routine fatigue screening and comprehensive multidimensional management strategies should be integrated into standard IBD care.展开更多
OBJECTIVE:To investigate the association between Traditional Chinese Medicine(TCM)constitution and fear of cancer recurrence(FCR)in breast cancer survivors.METHODS:A cross-sectional study was conducted among breast ca...OBJECTIVE:To investigate the association between Traditional Chinese Medicine(TCM)constitution and fear of cancer recurrence(FCR)in breast cancer survivors.METHODS:A cross-sectional study was conducted among breast cancer patients at Guang'anmen Hospital of the Chinese Academy of Traditional Chinese Medicine,China,during the period from April 9,2023,to July 2,2024.Data were collected on participants'common sociodemographic characteristics,medical history,scores on the Fear of Cancer Recurrence Inventory(FCRI),and TCM constitution classification.Statistical analyses employed independent samples t-test,χ2test,Fisher's exact test,one-way analysis of variance,Spearman's correlation coefficient,multiple linear regression analysis,and multivariate logistic regression analysis.RESULTS:A total of 279 eligible breast cancer patients enrolled in this study.The most prevalent TCM constitutions were‘Qi-depression',‘Peaceful'and‘Yangdeficiency'.All nine TCM constitutions of breast cancer patients exhibited significant correlations with FCR scores.The strongest positive correlation was observed between‘Qi-stagnation'and FCR(r=0.5576,P<0.0001),followed by‘Qi-deficiency'(r=0.4465,P<0.0001).By contrast,the Peaceful correlation showed a significant negative correlation with FCR(r=-0.363,P<0.0001).Multiple linear regression analysis showed that TCM constitution,lymph node metastasis,and endocrine therapy were influencing factors for FCR in breast cancer patients(P<0.05).Additionally,multivariate logistic regression analysis was performed to identify factors associated with TCM constitution in breast cancer patients.After adjusting for potential confounding factors including age,disease stage,pathological type,immunohistochemical status,lymph node metastasis,disease duration,and treatment modality,FCR,disease stage,age,and surgical modality were found to be significantly associated with TCM constitution(all P<0.05).CONCLUSION:This study demonstrates a significant association between TCM constitution and FCR in breast cancer patients,suggesting that FCR can potentially be interpreted within the theoretical framework of TCM.These findings thus provide a theoretical foundation for TCMC-informed management strategies targeting FCR in breast cancer patients.展开更多
Dear Editor,Psoriasis,a chronic inflammatory cutaneous condition,is characterized by the development of red plaques with silvery scales,significantly affecting patients'quality of life and mental health[1].This co...Dear Editor,Psoriasis,a chronic inflammatory cutaneous condition,is characterized by the development of red plaques with silvery scales,significantly affecting patients'quality of life and mental health[1].This condition is thought to affect approximately 2%of the Western population,with diagnosis peaking in early adulthood[2].Vitamin D,a fat-soluble vitamin,is essential for phospho-calcium metabolism,calcium homeostasis,and bone health.展开更多
BACKGROUND Cognitive impairment is a well-recognized complication of liver diseases,primarily associated with cirrhotic portal hypertension.However,its spectrum and prevalence in patients with non-cirrhotic portal hyp...BACKGROUND Cognitive impairment is a well-recognized complication of liver diseases,primarily associated with cirrhotic portal hypertension.However,its spectrum and prevalence in patients with non-cirrhotic portal hypertension due to hepatosplenic schistosomiasis(HSS)remain poorly characterized,particularly regarding domains beyond minimal hepatic encephalopathy(MHE).AIM To characterize cognitive performance and determine the prevalence of deficits across multiple domains in a large cohort of patients with HSS.METHODS This cross-sectional study enrolled 200 adult patients with confirmed HSS at a Brazilian reference center.Participants underwent a comprehensive psychometric battery,including Mini-Mental State Examination for global cognition,the animal verbal fluency test for MHE and semantic fluency,the clock drawing test for visuospatial and executive functions,the digit span test(DST)for attention and working memory,and the Goo-Go test for inhibitory control.Impairment was defined using established,education-adjusted cut-offs.RESULTS The cohort had a mean age of 56.4 years and limited formal education(mean 4.9 years).Global cognitive impairment,defined as a Mini-Mental Examination Score<25,was identified in 36.5%of patients.Domain-specific assessment revealed a high prevalence of deficits in visuospatial and planning abilities,affecting 67%of patients according to the clock drawing test.Working memory impairments were detected in 53.5%(forward DST)and 83%(backward DST)of participants.Abnormal performance on the Go/No-Go test,indicating deficits in inhibitory control,was observed in 66.5%of the sample.The animal verbal fluency test identified MHE in 24.5%of participants,a finding significantly associated with lower educational attainment(P<0.01).Notably,while MHE was strongly linked to the presence of portosystemic shunts(P=0.0018),deficits in other cognitive domains were highly prevalent regardless of portosystemic shunts status.CONCLUSION Cognitive impairment in HSS is highly prevalent and encompasses a broad range of deficits,extending well beyond MHE.These findings support the implementation of routine,multidimensional cognitive screening in standard management of HSS patients.展开更多
Objectives:Kidney stone disease is increasingly prevalent and may be linked to metabolic factors such as insulin resistance,but there is currently no direct evidence connecting estimated glucose disposal rate(eGDR)to ...Objectives:Kidney stone disease is increasingly prevalent and may be linked to metabolic factors such as insulin resistance,but there is currently no direct evidence connecting estimated glucose disposal rate(eGDR)to kidney stones.This study aimed to investigate the relationship between eGDR and kidney stone prevalence.Methods:We conducted a cross-sectional analysis utilizing data from the National Health and Nutrition Examination Survey(NHANES)from 2007–2018,including 29,753 participants aged 20 years and older.Weighted multivariable logistic regression and nonlinear models were employed to assess the relationship between eGDR and self-reported kidney stone history.Results:Among participants,9.90%reported having kidney stones.Multivariable analysis revealed that higher eGDR values were associated with decreased odds of kidney stones(odds ratio[OR]=0.92,95%CI:0.89–0.94).Participants in the highest eGDR tertile demonstrated approximately half the odds of kidney stones compared to those in the lowest tertile(adjusted OR=0.52,95%CI:0.43–0.64).Nonlinear analysis identified a threshold effect at eGDR=7.95,with significant inverse associations only observed above this threshold(OR=0.81,95%CI:0.71–0.92).Conclusions:This study identifies a nonlinear relationship between eGDR and kidney stones,with a threshold effect at eGDR=7.95.The inverse association was significant only when eGDR exceeded this threshold,suggesting the potential utility of eGDR as a clinical indicator for kidney stone risk assessment.Prospective studies are needed to establish causal relationships.展开更多
Objective:Postpartum nutrition plays a critical role in maternal recovery and long-term health.However,the nutritional status of working mothers in the postpartum period remains understudied.This study aimed to assess...Objective:Postpartum nutrition plays a critical role in maternal recovery and long-term health.However,the nutritional status of working mothers in the postpartum period remains understudied.This study aimed to assess the dietary quality of postpartum women in urban Beijing,identify occupational-related factors influencing their diet,and explore potential interventions to improve maternal nutrition during the postpartum period.Methods:In this cross-sectional analysis,554 women one year after delivery were recruited from ten community health centers.Sociodemographic,occupational and postpartum care variables were collected via questionnaire.Dietary intake over the preceding year was assessed using a food frequency questionnaire.The modified dietary balance index for postpartum women were used for dietary quality assessment.Results:The study revealed severe dietary imbalances among postpartum women,characterized by excessive consumption of cereals,eggs,and meats,while their intake of vegetables,fruits,and dairy products was inadequate.According to dietary balance index for postpartum women,66.25%of mothers showed varying degrees of excessive intake.45.31%of mothers experienced varying levels of insufficient intake,with only 19.86%of participants having a relatively balanced diet.Occupational differences were observed,with women in the commercial employment group showing higher levels of excessive food intake.The analysis of influencing factors showed that family monthly income,maternity leave,and postpartum care significantly affected the dietary quality.Conclusions:Postpartum women in Beijing experience widespread dietary imbalances,with both excesses and deficiencies.Occupational context and related factors significantly shape diet quality.These findings highlight the need for targeted nutritional interventions tailored to the specific challenges of different occupational groups.展开更多
Objective:To study the relationship between qi stagnation constitution and suboptimal health status(SHS)or lifestyle.Methods:From 2012 to 2013,we conducted a cross-sectional survey of 24159 Chinese individuals aged 12...Objective:To study the relationship between qi stagnation constitution and suboptimal health status(SHS)or lifestyle.Methods:From 2012 to 2013,we conducted a cross-sectional survey of 24159 Chinese individuals aged 12-80 years.The qi stagnation constitution was assessed using the Constitution in Chinese Medicine Questionnaire.Health status was evaluated through medical records and the Subhealth Measurement Scale V1.0(SHMS V1.0).Health-promoting lifestyles were measured using the Health-Promoting Lifestyle Profile Ⅱ(HPLP-Ⅱ).Results:Of the 24159 participants,16.1%and 15.2%were classified as“always”and“sometimes”having the qi stagnation constitution,respectively.Those classified as“rarely”having the qi stagnation constitution scored higher on both the HPLP-Ⅱ and SHMS V1.0.The participants classified as“always”having the qi stagnation constitution showed a significant association with SHS or disease compared to other imbalanced constitutions.Those in the“always”category were approximately 21 times more likely to be classified as having SHS(odds ratio[OR]:21.17,95%confidence interval[CI]:15.74-28.45),whereas those in the“sometimes”category were approximately six times more likely(OR:5.89,95%CI:5.04-6.90).Accordingly,the qi stagnation constitution score was significantly associated with the diagnosis of SHS,with an area under the curve of 0.77(P<.001).A score of 18.75 yielded the highest Youden Index(0.407),with a sensitivity of 60.5%and a specificity of 80.3%.Significant associations were observed between health-promoting lifestyles and qi stagnation constitution severity in an ordinal regression analysis(P<.001).Protective factors included stress management(OR:1.59),self-actualization(OR:1.57),and exercise(OR:1.36).In contrast,poorer interpersonal relationships(OR:0.79),greater health responsibilities(OR:0.86),and poorer nutrition(OR:0.91)were associated with increased severity.Conclusion:Modulating the qi stagnation constitution through lifestyle interventions may help prevent the progression of SHS to disease,which aligns with core preventive principles in traditional Chinese medicine.展开更多
AIM:To assess the relationship between dietary inflammatory index(DII)and prevalence of glaucoma among individuals aged 40y and above in the United States.METHODS:Participants were drawn from 2 cycles of the National ...AIM:To assess the relationship between dietary inflammatory index(DII)and prevalence of glaucoma among individuals aged 40y and above in the United States.METHODS:Participants were drawn from 2 cycles of the National Health and Nutrition Examination Survey(NHANES,2005-2008)for a cross-sectional study.DII was calculated from 24-hour dietary recall questionnaire conducted by experienced researchers and data analyzed in R according to the NHANES user guide,“Stratified Multi-stage Probability Sampling”.The relationship between DII and glaucoma was evaluated by multi-factor logistic regression analysis and the existence of a non-linear association examined by restricted cubic spline(RCS)analysis.RESULTS:A total of 5359 subjects were included and the cross-sectional analysis weighted to represent the US population of 109 million.DII was elevated in glaucoma patients(P<0.001)and smoking and alcohol use contributed to significant differences(P<0.001).DII correlated negatively with Healthy Eating Index(HEI)-2015(Spearman rank correlation coefficient,r=-0.49).RCS analysis showed a linear relationship between DII and glaucoma risk(P of non-linear relationship=0.575).CONCLUSION:An increased DII is strongly associated with high risk of glaucoma and diet-induced inflammation should be controlled to delay glaucoma progression.展开更多
OBJECTIVE:To investigate the difference in gut microbiota between population with damp-heat constitution(DHC)and balanced constitution(BC).METHODS:A multi-centered cross-sectional casecontrol study was conducted,which...OBJECTIVE:To investigate the difference in gut microbiota between population with damp-heat constitution(DHC)and balanced constitution(BC).METHODS:A multi-centered cross-sectional casecontrol study was conducted,which included 249 participants with damp-heat constitution or balanced constitution.Baseline information of participants was collected,and stool samples were collected for gut microbiota analysis.Principal coordinate analysis,linear discriminant analysis effect size analysis,receiver operating characteristic,random forest model,and phylogenetic investigation of communities by reconstruction of unobserved states methods were used to reveal the relationship between gut microbiota and the damp-heat constitution.RESULTS:Compared to those in the BC group,the richness and diversity of the microbiota,specifically those of several short-chain fatty acid producing genera such as Barnesiella,Coprobacter,and Butyricimonas,were significantly decreased in the DHC group.Regarding biological functions,flavonoid biosynthesis,propanoate metabolism,and nucleotide sugar metabolism were suppressed,while arachidonic acid metabolism and glutathione metabolism were enriched in the DHC group.Finally,a classifier based on the microbiota was constructed to discriminate between the DHC and BC populations.CONCLUSION:The gut microbiota of the DHC population exhibits significantly reduced diversity and is closely related to inflammation,metabolic disorders,and liver steatosis,which is consistent with clinical observations,thus serving as a potential diagnostic tool for traditional Chinese medicine constitution discrimination.展开更多
Objectives:This study aimed to classify young breast cancer patients into distinct ambivalence over emotional expression and to explore the factors influencingthe level of ambivalence over emotional expression.Methods...Objectives:This study aimed to classify young breast cancer patients into distinct ambivalence over emotional expression and to explore the factors influencingthe level of ambivalence over emotional expression.Methods:A total of 217 young breast cancer patients were enrolled from a tertiary Grade A oncology hospital in Tianjin,China,using the convenience sampling method.All participants completed the general questionnaire,Ambivalence over Emotion Expression Questionnaire(AEQ),and Family Adapt-Ability and Cohesion Evaluation Scales-Chinese Version(FACES-CV).We employed exploratory latent profileanalysis for ambivalence over emotional expression profilingand logistic regression analysis to identify the influentialfactors Results:The results of the latent profileanalysis supported the models of four latent profiles,which were definedas“low conflict-lowexpression reflection”(19.2%),“high conflict-high inhibition expression”(43.9%),“moderate conflict-highregret expression”(18.1%),and“moderate conflict-desire understand”(18.8%).Logistic regression revealed that family cohesion,marital status,residence,per capita monthly income,and cancer stage were the influencingfactors of ambivalence over emotional expression in young breast cancer patients(P<0.05)Conclusions:Levels of ambivalence over emotional expression ameast cancer patients with breast cancer were highly heterogeneous.Medical staff should provide psychological counseling and health education tailored to the unique characteristics of emotional expression ambivalence in different patient groups to promote healthy emotional expression among patients.展开更多
Background Self-care behaviors are essential for managing type 2 diabetes mellitus(T2DM),even among patients receiving specialized clinical care.However,limited evidence exists on how these behaviors affect glycemic o...Background Self-care behaviors are essential for managing type 2 diabetes mellitus(T2DM),even among patients receiving specialized clinical care.However,limited evidence exists on how these behaviors affect glycemic outcomes in Nigerian patients already engaged with endocrinology services.This study assessed self-care practices and their association with glycemic control among T2DM patients attending two specialized clinics in Gusau,Nigeria.Methods A cross-sectional study was conducted among 262 adult T2DM patients from two endocrinology clinics in Gusau,Nigeria.Participants were recruited using a convenience sampling approach during routine clinic visits.Each completed questionnaires on demographics,the Summary of Diabetes Self-Care Activities(SDSCA),and the Morisky Medication Adherence Scale(MMAS-4).Fasting blood glucose levels were used to assess glycemic control.Logistic regression analyzed the association between self-care behaviors and glycemic outcomes;linear regression identified influencing factors.Results Among 262 participants,45.8%had uncontrolled fasting blood glucose(≥7 mmol/L).Higher overall self-care scores were significantly associated with better glycemic control(OR 0.83;95%CI 0.78-0.88;P<0.001).Dietary adherence(OR 0.72;95%CI 0.61-0.85),physical activity(OR 0.74;95%CI 0.65-0.84),and blood glucose monitoring(OR 0.22;95%CI 0.09-0.54)were significantly associated with improved glycemic outcomes.Foot care(OR 0.98;P=0.797)and medication adherence(OR 3.21;P=0.095)showed no significant association.Males,older adults(≥60 years),and Yoruba/Igbo participants had lower dietary scores,while exercise scores were higher among males,singles,and Igbo patients.Longer diabetes duration(≥20 years)was linked to better medication adherence and exercise.Conclusions Self-care behaviors were significantly associated with glycemic control among T2DM patients attending two specialized endocrinology clinics in Gusau,Nigeria.Interventions tailored to demographic and cultural contexts are essential to strengthen adherence in key areas such as diet,physical activity,and glucose monitoring.These findings underscore the importance of supporting self-management,even in patients with established access to clinical care.展开更多
Background:The bibliometrics of acupuncture are growing rapidly.However,the absence of reporting guidelines may lead to significant duplication and waste,thereby undermining the research’s value.To address this,a kno...Background:The bibliometrics of acupuncture are growing rapidly.However,the absence of reporting guidelines may lead to significant duplication and waste,thereby undermining the research’s value.To address this,a knowledge mapping was generated based on published studies to investigate the characteristics of bibliometric studies on acupuncture and the extent of duplicate publications,with the overarching goal of providing a comprehensive overview of the knowledge structure in this field.Methods:This cross-sectional study used three databases(PubMed,Web of Science,and Scopus)to identify relevant studies up to May 1,2024.In addition,the reference lists were retrieved as a supplement.To track research trends,we employed Microsoft Excel and R software to extract,code,and analyze information.Study selection,data extraction,and validation were performed independently by at least two reviewers.The reporting quality of included studies was assessed using the Preliminary guideline for reporting bibliometric reviews of the biomedical literature(BIBLIO).Results:Among the 6,221 bibliometric reviews examined,113 relevant publications were identified,80 focusing on various diseases/conditions.The annual number of publications has gradually increased,with the output in the past four years being 3.52 times higher than that before 2020.China(106)and Chengdu University of Traditional Chinese Medicine(16)have the highest number of publications.The most prolific author is Fan-Rong Liang,with six articles.The first bibliometric study,by Hai-Yan Li,was published in 2010.Journal of Pain Research,with 36 articles,holds the most publications.The top three diseases:diseases of the nervous system;symptoms,signs,or clinical findings not elsewhere classified;and mental,behavioral,or neurodevelopmental disorders.There may be potential duplication in research on 13 diseases/conditions,notably stroke,migraine,pain/analgesia,cancer pain,shoulder pain,facial paralysis/bell’s palsy,chronic pain,and cognitive impairment.In BIBLIO,the most frequently missing items are issuesopics(item 2),quality assessment(item 11),and descriptive findings(item 13).Conclusion:This study demonstrates that acupuncture bibliometrics is actively utilized to identify dominant diseases/conditions,aiding scholars in understand the knowledge structure and main topics.Although the number of related studies is increasing,with an average of 25 studies annually,overlap in some areas highlights the need for adherence to reporting guidelines and careful topic selection to ensure truly valuable insights and knowledge contributions.The adherence to BIBLIO’s 20 proposed items across analyzed articles,highlighting important in reporting practices.展开更多
association with academic and clinical performance.This study aimed to determine the EI level of hospital-based nursing students and examine differences between full-time and part-time students.Methods:We conducted a ...association with academic and clinical performance.This study aimed to determine the EI level of hospital-based nursing students and examine differences between full-time and part-time students.Methods:We conducted a cross-sectional study in a hospital-based nursing school.EI level was measured using the Schutte Self-report Emotional Intelligence Scale(SSEIS).Results:We recruited 287 participants(mean age:21.9 years).Their mean SSEIS score was 119.6(95%CI=118.57-120.65).The mean SSEIS scores of 172 full-time and 115 part-time nurses were 120.7(95%CI=119.3-122.0)and 118.1(95%CI=116.5-119.6),respectively.There was no significant difference between the groups.Conclusion:The EI difference between full-time and part-time nursing students was statistically insignificant.The need for further EI development among both full-time and part-time students must be addressed.展开更多
BACKGROUND The triglyceride glucose-body mass index(TyG-BMI)is a novel indicator of insulin resistance(IR).Obstructive sleep apnea(OSA)is a prevalent disorder characterized by recurrent complete or partial collapse of...BACKGROUND The triglyceride glucose-body mass index(TyG-BMI)is a novel indicator of insulin resistance(IR).Obstructive sleep apnea(OSA)is a prevalent disorder characterized by recurrent complete or partial collapse of the pharyngeal airway during sleep;however,the relationship between these two conditions remains unexplored.We hypothesized that a higher TyG-BMI is associated with the occurrence of OSA.AIM To assess the association between TyG-BMI and OSA in adults in the United States.METHODS A cross-sectional study was conducted utilizing data from the National Health and Nutrition Examination Surveys spanning from 2005-2008 to 2015-2018.TyGBMI was calculated as Ln[triglyceride(mg/dL)×fasting blood glucose(mg/dL)/2]×BMI.Restricted cubic splines were used to analyze the risk of TyG-BMI and OSA occurrence.To identify potential nonlinear relationships,we combined Cox proportional hazard regression with smooth curve fitting.We also conducted sensitivity and subgroup analyses to verify the robustness of our findings.RESULTS We included 16794 participants in the final analysis.Multivariate regression analysis showed that participants with a higher TyG-BMI had a higher OSA incidence.After adjusting for all covariates,TyG-BMI was positively correlated with the prevalence of OSA(odds ratio:1.28;95%confidence interval:1.17,1.40;P<0.001);no significant nonlinear relationship was observed.Subgroup analysis showed no strong correlation between TyG-BMI and OSA in patients with diabetes.The correlation between TyG-BMI and OSA was influenced by age,sex,smoking status,marital status,hypertensive stratification,and obesity;these subgroups played a moderating role between TyGBMI and OSA.Even after adjusting for all covariates,there was a positive association between TYG-BMI and OSA prevalence.CONCLUSION A higher TyG-BMI index is linked to higher chances of developing OSA.As TyG-BMI is an indicator of IR,managing IR may help reduce the risk of OSA.展开更多
Objective:This study aimed to examine the association between parent-child relationships and physically aggressive behavior among adolescents.Methods:This is a cross-sectional study that uses secondary data from the 2...Objective:This study aimed to examine the association between parent-child relationships and physically aggressive behavior among adolescents.Methods:This is a cross-sectional study that uses secondary data from the 2015 Indonesia Global School-Based Health Survey(IGSHS).Health surveys were conducted in 75 schools representing three regions(Sumatra,Java-Bali;Outer Sumatra;and Java-Bali)in 26 provinces and 68 districts/cities in Indonesia(N=10,139 students).Students who participated were aged 12-19 years,were enrolled in public schools in the junior and high school levels.Results:It has been seen that for most middle-aged adolescents(58.7%),their parents(25%-29%)pay less attention to academic assignments(homework),problems,and use of free time.The most significant factors that influence adolescents to commit violence are smoking and consuming alcohol.Adolescents who smoke are twice as likely to commit physical violence compared with adolescents who do not smoke(OR=2.005;95%CI=1.7062-2.396).Meanwhile,adolescents who consume alcohol are 1.8 times more likely to commit physical violence compared with adolescents who do not consume alcohol(OR=1.807;95%CI=1.421-2.298).Conclusions:Through educational activities and consultations,this study’s findings are valuable for establishing parenting programs among those concerned about their children’s aggressive behavior.Meanwhile,counseling programs can be started in schools by conducting self-detection of negative adolescent behavior,such as screening for smoking,alcohol consumption,sleep issues,and attempted suicide.展开更多
Arterial stiffness is considered an important indicator reflecting age-related changes in the vascular wall[1]and the risk of developing comorbidities,[2]primarily cardiovascular diseases.[3]Cardiovascular diseases re...Arterial stiffness is considered an important indicator reflecting age-related changes in the vascular wall[1]and the risk of developing comorbidities,[2]primarily cardiovascular diseases.[3]Cardiovascular diseases remain the leading cause of death worldwide.Many factors influence the rate of arterial aging.Research results have confirmed that arterial wall stiffness increases with an increasing number of risk factors,[4]as each of them acts independently through various mechanisms,adversely affecting the structure and function of the cardiovascular system.展开更多
Background:Since the trauma knowledge of trauma providers correlates with the outcomes of injured patients,this study aims to assess the socio-demographic characteristics and levels of trauma knowledge of trainees in ...Background:Since the trauma knowledge of trauma providers correlates with the outcomes of injured patients,this study aims to assess the socio-demographic characteristics and levels of trauma knowledge of trainees in the China trauma care training(CTCT)program in addition to their post-course test results to provide support for the development of trauma care training programs and trauma systems in China.Methods:A cross-sectional study was conducted by collecting demographic information,hospital-related information and trauma knowledge of the trainees from 19 regions in China.All participants were assessed by questionnaires collecting the socio-demographic data,the trauma care knowledge levels and the information of the hospitals.Results:There were 955 males(78.9%)and 256 females(21.1%)enrolled.Among them,854 were physicians(70.5%),357 were registered nurses(29.5%).In addition,64 of them also played an administrative role in the hospitals(5.3%).The score of the trainees who were members of the emergency department staff(72.59±14.13)was the highest among the scores of all the personnel surveyed,followed by those of the trainees from the intensive care unit(ICU)(71.17±12.72),trauma surgery department(67.26±13.81),orthopedics department(70.36±14.48),general surgery department(69.91±14.79)and other departments(69.93±16.91),P=0.031.The score of the professors(73.09±15.05)was higher than those of the associate professors(72.40±14.71),lecturers(70.07±14.25)and teaching assistants(67.58±15.16),P<0.0001.The score of the individuals who attended experts’trauma lectures(72.22±14.45)was higher than that of individuals who did not attend the lectures(69.33±15.17),P=0.001.The mean scores before and after the training were 71.02±14.82 and 84.24±13.77,respectively,P<0.001.The mean score of trauma knowledge after the training of trainees from different provinces and with different educational backgrounds was higher than that before the training,with a statistically significant difference(P<0.05).Conclusions:The level of trauma knowledge of trauma care providers was associated with their department,professional position and previous participation in related academic conferences.Trauma care experience and participation in academic lectures and training program including CTCT may effectively improve individuals’level of trauma knowledge.展开更多
Summary:Nurses'work-related fatigue has been recognized as a threat to nurse health and patient safety.The aim of this study was to assess the prevalence of fatigue among first-line nurses combating with COVID-19 ...Summary:Nurses'work-related fatigue has been recognized as a threat to nurse health and patient safety.The aim of this study was to assess the prevalence of fatigue among first-line nurses combating with COVID-19 in Wuhan,China,and to analyze its influencing factors on fatigue.A multi-center,descriptive,cross-sectional design with a convenience sample was used.The statistical population consisted of the first-line nurses in 7 tertiary general hospitals from March 3,2020 to March 10,2020 in Wuhan of China.A total of 2667 samples from 2768 contacted participants completed the investgation,with a response rate of 96.35%.Social-demographic questionnaire,work-related questionnaire,Fatigue Scale-14,Generalized Anxiety Disorder-7,Patient Health Questionnaire-9,and Chinese Perceived Stress Scale were used to conduct online survey.The descriptive statistic of nurses'social-demographic characteristics was conducted,and the related variables of work,anxiety,depression,perceived stress and fatigue were analyzed by Z-tests,nonparametric test and Pearson's correlation analysis.The significant factors which resulted in nurses'fatigue were further analyzed by multiple linear regression analysis.The median score for the first-line nurses'fatigue in Wuhan was 4(2,8).The median score of physical and mental fatigue of them was 3(1,6)and 1(0,3)respectively.According to the scoring criteria,35.06%nurses(w=935)of all participants were in the fatigue status,their median score of fatigue was 10(8,11),and the median score of physical and mental fatigue of them was 7(5,8)and 3(2,4)respectively.Multiple linear regression analysis revealed the participants in the risk groups of anxiety,depression and perceived stress had higher scores on physical and mental fatigue and the statistically significant positive correlation was observed between the variables and nurses'fatigue,the frequency of exercise and nurses'fatigue had a statistically significant negative correlation,and average daily working hours had a significantly positive correlation with nurses'fatigue,and the frequency of weekly night shift had a low positive correlation with nurses'fatigue(P<0.01).There was a moderate level of fatigue among the first-line nurses fighting against COVID-19 pandemic in Wuhan,China.Government and health authorities need to formulate and take effective intervention strategies according to the relevant risk factors,and undertake preventive measures aimed at reducing health hazards due to increased work-related fatigue among first-line nurses,and to enhance their health status and provide a safe occupational environment worldwide.Promoting both medical and nursing safety while combating with the pandemic currently is warranted.展开更多
基金Supported by Ministry of Science and Technology of the People’s Republic of China,No.2018YFC1705602.
摘要BACKGROUND Although numerous studies indicate that adverse mental states negatively affect sleep,few have systematically analyzed the association between various adverse mental states and insomnia.Furthermore,potential gender differences within such associations remain underexplored.AIM To investigate gender differences in correlations between adverse mental states and insomnia,and identify genderspecific risk factors for severe insomnia.METHODS A multicenter cross-sectional survey method was employed.A total of 2009 adult participants(2019-2021)completed an insomnia clinical assessment form.The form covered sociodemographic information,14 subjectively reported adverse mental states,core insomnia symptoms,and the Pittsburgh Sleep Quality Index.RESULTS Depression,apathy,fatigue,impatience-irritability,grief,forgetfulness,and slow response were significantly associated with insomnia.Timidity,indecision,suspiciousness,catatonia,decreased willpower,taciturnity,and inattention showed no significant association with insomnia.Grief(r=0.062,P<0.05),fatigue(r=0.065,P<0.05),and slow response(r=0.080,P<0.01)were correlated with increased time to fall asleep in women;no mental factors influencing sleep latency were identified in men.Apathy(r=0.073,P<0.05)was associated only with increased nocturnal awakenings in men,but not in women.Impatience-irritability was a risk factor for severe insomnia exclusively in men(odds ratio=1.62,95%CI:1.13-2.32,P=0.009),while grief was a risk factor specifically for women(odds ratio=1.83,95%CI:1.20-2.80,P=0.005).CONCLUSION Not all adverse mental states are significantly associated with insomnia,and the correlation between adverse mental states and insomnia varies according to gender and specific sleep dimensions.
基金provided by grant KM202410025014 from Beijing Municipal Education Commissiongrant L251006 from Beijing Natural Science Foundationby grant No.YYZZ202318 from Beijing Friendship Hospital,Capital Medical University.
摘要Background:Benign prostatic hyperplasia(BPH)is prevalent among aging men.Whether exposure to internet-derived health information is associated with disease awareness and symptom burden at initial diagnosis remains unclear.Methods:We conducted a cross-sectional study of 400 newly diagnosed BPH outpatients.Participants were classified by prior exposure to internet-derived BPH content.BPH awareness and International Prostate Symptom Scores(IPSS)were compared using the Mann-Whitney U test and multivariate linear regression adjusted for age,education,and disposable income.Stratified analyses were performed according to educational attainment,disposable income,and content format.Results:Exposure to internet-derived BPH content was independently associated with higher awareness and lower IPSS.Compared with unexposed participants,exposed participants had higher awareness(median 1.5 vs.0)and lower IPSS(median 7.0 vs.10.5)(both p<0.001).In multivariable models,being unexposed was associated with a 1.39-point lower awareness score and a 2.20-point higher IPSS(both p<0.001).In stratified analyses,the associations remained significant across education and income strata.Among exposed participants,those accessing text-based or mixed-format content had higher awareness and lower IPSS than those exposed to videos only(both p<0.001).Conclusions:This study shows that exposure to internet-derived health content is significantly associated with higher BPH awareness and a lower symptom burden at initial presentation.Text-based or mixed-format content may be more effective than video-only formats.
基金Hubei Provincial Department of Education(Project No.:24Q186,24Q192)。
摘要Objective:To investigate the prevalence of fatigue and identify its associated influencing factors in patients with inflammatory bowel disease(IBD),thereby providing an evidence base for targeted clinical interventions.Methods:A cross-sectional survey design was adopted.A total of 204 patients with confirmed IBD diagnoses were consecutively enrolled from the gastroenterology outpatient clinics and inpatient wards of a tertiary-level hospital in Shiyan,Hubei Province,China,between June 2023 and June 2024.Fatigue was assessed using the IBD-Fatigue(IBD-F)scale.Sociodemographic characteristics,disease-related parameters,inflammatory biomarkers,and psychological status were simultaneously collected.Univariable analyses and multivariable logistic regression were performed to identify independent determinants of fatigue.Results:Among the 204 enrolled IBD patients,142(69.61%)had fatigue(IBD-F≥13).Univariable analyses revealed that sex,disease activity status,anemia,C-reactive protein(CRP)level,serum albumin level,sleep quality,anxiety,and depression were significantly associated with fatigue occurrence(all p<0.05).Multivariable logistic regression identified active disease phase(OR=3.12,95%CI:1.54–6.31,p=0.002),comorbid anemia(OR=2.87,95%CI:1.42–5.80,p=0.004),elevated CRP(OR=2.43,95%CI:1.21–4.88,p=0.013),poor sleep quality(OR=2.19,95%CI:1.10–4.36,p=0.026),and comorbid depression(OR=3.56,95%CI:1.76–7.19,p=0.001)as independent risk factors for fatigue;serum albumin≥35 g/L was identified as a protective factor(OR=0.48,95%CI:0.24–0.96,p=0.037).Fatigue was significantly and negatively correlated with health-related quality of life(r=−0.61,p<0.001).Conclusion:The prevalence of fatigue in IBD patients is as high as 69.61%,and it is independently associated with disease activity,elevated inflammatory markers,anemia,sleep disturbance,and depression,significantly impairing patients’quality of life.Routine fatigue screening and comprehensive multidimensional management strategies should be integrated into standard IBD care.
基金Scientific and Technological Innovation Project of the China Academy of Chinese Medical Sciences:Series Research on Traditional Chinese Medicine Oncology Nutrition(No.CI2022C002-03)。
摘要OBJECTIVE:To investigate the association between Traditional Chinese Medicine(TCM)constitution and fear of cancer recurrence(FCR)in breast cancer survivors.METHODS:A cross-sectional study was conducted among breast cancer patients at Guang'anmen Hospital of the Chinese Academy of Traditional Chinese Medicine,China,during the period from April 9,2023,to July 2,2024.Data were collected on participants'common sociodemographic characteristics,medical history,scores on the Fear of Cancer Recurrence Inventory(FCRI),and TCM constitution classification.Statistical analyses employed independent samples t-test,χ2test,Fisher's exact test,one-way analysis of variance,Spearman's correlation coefficient,multiple linear regression analysis,and multivariate logistic regression analysis.RESULTS:A total of 279 eligible breast cancer patients enrolled in this study.The most prevalent TCM constitutions were‘Qi-depression',‘Peaceful'and‘Yangdeficiency'.All nine TCM constitutions of breast cancer patients exhibited significant correlations with FCR scores.The strongest positive correlation was observed between‘Qi-stagnation'and FCR(r=0.5576,P<0.0001),followed by‘Qi-deficiency'(r=0.4465,P<0.0001).By contrast,the Peaceful correlation showed a significant negative correlation with FCR(r=-0.363,P<0.0001).Multiple linear regression analysis showed that TCM constitution,lymph node metastasis,and endocrine therapy were influencing factors for FCR in breast cancer patients(P<0.05).Additionally,multivariate logistic regression analysis was performed to identify factors associated with TCM constitution in breast cancer patients.After adjusting for potential confounding factors including age,disease stage,pathological type,immunohistochemical status,lymph node metastasis,disease duration,and treatment modality,FCR,disease stage,age,and surgical modality were found to be significantly associated with TCM constitution(all P<0.05).CONCLUSION:This study demonstrates a significant association between TCM constitution and FCR in breast cancer patients,suggesting that FCR can potentially be interpreted within the theoretical framework of TCM.These findings thus provide a theoretical foundation for TCMC-informed management strategies targeting FCR in breast cancer patients.
基金supported by the National Natural Science Foundation of China(Grant Nos.82573974 and 82373475)to Z.Y.
摘要Dear Editor,Psoriasis,a chronic inflammatory cutaneous condition,is characterized by the development of red plaques with silvery scales,significantly affecting patients'quality of life and mental health[1].This condition is thought to affect approximately 2%of the Western population,with diagnosis peaking in early adulthood[2].Vitamin D,a fat-soluble vitamin,is essential for phospho-calcium metabolism,calcium homeostasis,and bone health.
摘要BACKGROUND Cognitive impairment is a well-recognized complication of liver diseases,primarily associated with cirrhotic portal hypertension.However,its spectrum and prevalence in patients with non-cirrhotic portal hypertension due to hepatosplenic schistosomiasis(HSS)remain poorly characterized,particularly regarding domains beyond minimal hepatic encephalopathy(MHE).AIM To characterize cognitive performance and determine the prevalence of deficits across multiple domains in a large cohort of patients with HSS.METHODS This cross-sectional study enrolled 200 adult patients with confirmed HSS at a Brazilian reference center.Participants underwent a comprehensive psychometric battery,including Mini-Mental State Examination for global cognition,the animal verbal fluency test for MHE and semantic fluency,the clock drawing test for visuospatial and executive functions,the digit span test(DST)for attention and working memory,and the Goo-Go test for inhibitory control.Impairment was defined using established,education-adjusted cut-offs.RESULTS The cohort had a mean age of 56.4 years and limited formal education(mean 4.9 years).Global cognitive impairment,defined as a Mini-Mental Examination Score<25,was identified in 36.5%of patients.Domain-specific assessment revealed a high prevalence of deficits in visuospatial and planning abilities,affecting 67%of patients according to the clock drawing test.Working memory impairments were detected in 53.5%(forward DST)and 83%(backward DST)of participants.Abnormal performance on the Go/No-Go test,indicating deficits in inhibitory control,was observed in 66.5%of the sample.The animal verbal fluency test identified MHE in 24.5%of participants,a finding significantly associated with lower educational attainment(P<0.01).Notably,while MHE was strongly linked to the presence of portosystemic shunts(P=0.0018),deficits in other cognitive domains were highly prevalent regardless of portosystemic shunts status.CONCLUSION Cognitive impairment in HSS is highly prevalent and encompasses a broad range of deficits,extending well beyond MHE.These findings support the implementation of routine,multidimensional cognitive screening in standard management of HSS patients.
基金supported by the Doctoral Fund Project of North Sichuan Medical College(grant number:CBY22-QDA26)the Opening Project of the Medical Imaging Key Laboratory of Sichuan Province(grant number:MIKL202408).
摘要Objectives:Kidney stone disease is increasingly prevalent and may be linked to metabolic factors such as insulin resistance,but there is currently no direct evidence connecting estimated glucose disposal rate(eGDR)to kidney stones.This study aimed to investigate the relationship between eGDR and kidney stone prevalence.Methods:We conducted a cross-sectional analysis utilizing data from the National Health and Nutrition Examination Survey(NHANES)from 2007–2018,including 29,753 participants aged 20 years and older.Weighted multivariable logistic regression and nonlinear models were employed to assess the relationship between eGDR and self-reported kidney stone history.Results:Among participants,9.90%reported having kidney stones.Multivariable analysis revealed that higher eGDR values were associated with decreased odds of kidney stones(odds ratio[OR]=0.92,95%CI:0.89–0.94).Participants in the highest eGDR tertile demonstrated approximately half the odds of kidney stones compared to those in the lowest tertile(adjusted OR=0.52,95%CI:0.43–0.64).Nonlinear analysis identified a threshold effect at eGDR=7.95,with significant inverse associations only observed above this threshold(OR=0.81,95%CI:0.71–0.92).Conclusions:This study identifies a nonlinear relationship between eGDR and kidney stones,with a threshold effect at eGDR=7.95.The inverse association was significant only when eGDR exceeded this threshold,suggesting the potential utility of eGDR as a clinical indicator for kidney stone risk assessment.Prospective studies are needed to establish causal relationships.
基金supported by an Innovation Fund for Medical Sciences of the Chinese Academy of Medical Sciences (Grant No.2019-I2M-2-007).
摘要Objective:Postpartum nutrition plays a critical role in maternal recovery and long-term health.However,the nutritional status of working mothers in the postpartum period remains understudied.This study aimed to assess the dietary quality of postpartum women in urban Beijing,identify occupational-related factors influencing their diet,and explore potential interventions to improve maternal nutrition during the postpartum period.Methods:In this cross-sectional analysis,554 women one year after delivery were recruited from ten community health centers.Sociodemographic,occupational and postpartum care variables were collected via questionnaire.Dietary intake over the preceding year was assessed using a food frequency questionnaire.The modified dietary balance index for postpartum women were used for dietary quality assessment.Results:The study revealed severe dietary imbalances among postpartum women,characterized by excessive consumption of cereals,eggs,and meats,while their intake of vegetables,fruits,and dairy products was inadequate.According to dietary balance index for postpartum women,66.25%of mothers showed varying degrees of excessive intake.45.31%of mothers experienced varying levels of insufficient intake,with only 19.86%of participants having a relatively balanced diet.Occupational differences were observed,with women in the commercial employment group showing higher levels of excessive food intake.The analysis of influencing factors showed that family monthly income,maternity leave,and postpartum care significantly affected the dietary quality.Conclusions:Postpartum women in Beijing experience widespread dietary imbalances,with both excesses and deficiencies.Occupational context and related factors significantly shape diet quality.These findings highlight the need for targeted nutritional interventions tailored to the specific challenges of different occupational groups.
基金supported by the National Natural Science Foundation of China(T2341019)NSFC-Guangdong Joint Fund(U1132001)+9 种基金General Program of the National Natural Science Foundation of China(82174243 and 82204948)Natural Science Foundation of Guangdong Province,China(2023A1515110757)Guangzhou Science and Technology Plan Project(2024B03J1343)Major Scientific and Technological Project of Guangzhou Municipal Health Commission(20252D003)Research Project of Traditional Chinese Medicine Bureau of Guangdong Province(20241208)General project of Beijing Natural Science Foundation(7242227)Fundamental Research Funds for the Central Universities(BZY-JMZY-2022-001 and 2023-JYB-JBZD-009)High-level Key Discipline of the National Administration of Traditional Chinese Medicine-Traditional Chinese Constitutional Medicine(zyyzdxk-2023251)Major Science and Technology Special Projects in Hubei Province(2023BCA005)the Chief Scientist Research Project of Hubei Shizhen Laboratory(HSL2024SX0002).
摘要Objective:To study the relationship between qi stagnation constitution and suboptimal health status(SHS)or lifestyle.Methods:From 2012 to 2013,we conducted a cross-sectional survey of 24159 Chinese individuals aged 12-80 years.The qi stagnation constitution was assessed using the Constitution in Chinese Medicine Questionnaire.Health status was evaluated through medical records and the Subhealth Measurement Scale V1.0(SHMS V1.0).Health-promoting lifestyles were measured using the Health-Promoting Lifestyle Profile Ⅱ(HPLP-Ⅱ).Results:Of the 24159 participants,16.1%and 15.2%were classified as“always”and“sometimes”having the qi stagnation constitution,respectively.Those classified as“rarely”having the qi stagnation constitution scored higher on both the HPLP-Ⅱ and SHMS V1.0.The participants classified as“always”having the qi stagnation constitution showed a significant association with SHS or disease compared to other imbalanced constitutions.Those in the“always”category were approximately 21 times more likely to be classified as having SHS(odds ratio[OR]:21.17,95%confidence interval[CI]:15.74-28.45),whereas those in the“sometimes”category were approximately six times more likely(OR:5.89,95%CI:5.04-6.90).Accordingly,the qi stagnation constitution score was significantly associated with the diagnosis of SHS,with an area under the curve of 0.77(P<.001).A score of 18.75 yielded the highest Youden Index(0.407),with a sensitivity of 60.5%and a specificity of 80.3%.Significant associations were observed between health-promoting lifestyles and qi stagnation constitution severity in an ordinal regression analysis(P<.001).Protective factors included stress management(OR:1.59),self-actualization(OR:1.57),and exercise(OR:1.36).In contrast,poorer interpersonal relationships(OR:0.79),greater health responsibilities(OR:0.86),and poorer nutrition(OR:0.91)were associated with increased severity.Conclusion:Modulating the qi stagnation constitution through lifestyle interventions may help prevent the progression of SHS to disease,which aligns with core preventive principles in traditional Chinese medicine.
基金Supported by the National Natural Science Foundation of China(No.82074500)CACMS Innovation Fund(No.CI2021A02605)+1 种基金Administration of Traditional Chinese Medicine of Zhejiang Province(No.2024ZR029)Science and Technology Program of Wenzhou City(No.Y2023210).
摘要AIM:To assess the relationship between dietary inflammatory index(DII)and prevalence of glaucoma among individuals aged 40y and above in the United States.METHODS:Participants were drawn from 2 cycles of the National Health and Nutrition Examination Survey(NHANES,2005-2008)for a cross-sectional study.DII was calculated from 24-hour dietary recall questionnaire conducted by experienced researchers and data analyzed in R according to the NHANES user guide,“Stratified Multi-stage Probability Sampling”.The relationship between DII and glaucoma was evaluated by multi-factor logistic regression analysis and the existence of a non-linear association examined by restricted cubic spline(RCS)analysis.RESULTS:A total of 5359 subjects were included and the cross-sectional analysis weighted to represent the US population of 109 million.DII was elevated in glaucoma patients(P<0.001)and smoking and alcohol use contributed to significant differences(P<0.001).DII correlated negatively with Healthy Eating Index(HEI)-2015(Spearman rank correlation coefficient,r=-0.49).RCS analysis showed a linear relationship between DII and glaucoma risk(P of non-linear relationship=0.575).CONCLUSION:An increased DII is strongly associated with high risk of glaucoma and diet-induced inflammation should be controlled to delay glaucoma progression.
基金National Nonprofit Institute Research Grant for the Institute of Basic Theory for Chinese Medicine,China Academy of Chinese Medical Sciences:Mechanism of Regulating Phlegm-Dampness Constitution to Prevent Metabolic Diseases based on Gut Microbiota-host DNA Methylation(No.YZ-202151)。
摘要OBJECTIVE:To investigate the difference in gut microbiota between population with damp-heat constitution(DHC)and balanced constitution(BC).METHODS:A multi-centered cross-sectional casecontrol study was conducted,which included 249 participants with damp-heat constitution or balanced constitution.Baseline information of participants was collected,and stool samples were collected for gut microbiota analysis.Principal coordinate analysis,linear discriminant analysis effect size analysis,receiver operating characteristic,random forest model,and phylogenetic investigation of communities by reconstruction of unobserved states methods were used to reveal the relationship between gut microbiota and the damp-heat constitution.RESULTS:Compared to those in the BC group,the richness and diversity of the microbiota,specifically those of several short-chain fatty acid producing genera such as Barnesiella,Coprobacter,and Butyricimonas,were significantly decreased in the DHC group.Regarding biological functions,flavonoid biosynthesis,propanoate metabolism,and nucleotide sugar metabolism were suppressed,while arachidonic acid metabolism and glutathione metabolism were enriched in the DHC group.Finally,a classifier based on the microbiota was constructed to discriminate between the DHC and BC populations.CONCLUSION:The gut microbiota of the DHC population exhibits significantly reduced diversity and is closely related to inflammation,metabolic disorders,and liver steatosis,which is consistent with clinical observations,thus serving as a potential diagnostic tool for traditional Chinese medicine constitution discrimination.
基金funded by Tianjin Key Medical Discipline(Specialty)Construction Project,China(Grant No.TJYXZDXK-011A)Tianjin Medical University Cancer Institute&Hospital Nursing Special Fund Project(H2304)。
摘要Objectives:This study aimed to classify young breast cancer patients into distinct ambivalence over emotional expression and to explore the factors influencingthe level of ambivalence over emotional expression.Methods:A total of 217 young breast cancer patients were enrolled from a tertiary Grade A oncology hospital in Tianjin,China,using the convenience sampling method.All participants completed the general questionnaire,Ambivalence over Emotion Expression Questionnaire(AEQ),and Family Adapt-Ability and Cohesion Evaluation Scales-Chinese Version(FACES-CV).We employed exploratory latent profileanalysis for ambivalence over emotional expression profilingand logistic regression analysis to identify the influentialfactors Results:The results of the latent profileanalysis supported the models of four latent profiles,which were definedas“low conflict-lowexpression reflection”(19.2%),“high conflict-high inhibition expression”(43.9%),“moderate conflict-highregret expression”(18.1%),and“moderate conflict-desire understand”(18.8%).Logistic regression revealed that family cohesion,marital status,residence,per capita monthly income,and cancer stage were the influencingfactors of ambivalence over emotional expression in young breast cancer patients(P<0.05)Conclusions:Levels of ambivalence over emotional expression ameast cancer patients with breast cancer were highly heterogeneous.Medical staff should provide psychological counseling and health education tailored to the unique characteristics of emotional expression ambivalence in different patient groups to promote healthy emotional expression among patients.
基金funded by the Bill and Melinda Gates Foundation(No.INV-018912).
摘要Background Self-care behaviors are essential for managing type 2 diabetes mellitus(T2DM),even among patients receiving specialized clinical care.However,limited evidence exists on how these behaviors affect glycemic outcomes in Nigerian patients already engaged with endocrinology services.This study assessed self-care practices and their association with glycemic control among T2DM patients attending two specialized clinics in Gusau,Nigeria.Methods A cross-sectional study was conducted among 262 adult T2DM patients from two endocrinology clinics in Gusau,Nigeria.Participants were recruited using a convenience sampling approach during routine clinic visits.Each completed questionnaires on demographics,the Summary of Diabetes Self-Care Activities(SDSCA),and the Morisky Medication Adherence Scale(MMAS-4).Fasting blood glucose levels were used to assess glycemic control.Logistic regression analyzed the association between self-care behaviors and glycemic outcomes;linear regression identified influencing factors.Results Among 262 participants,45.8%had uncontrolled fasting blood glucose(≥7 mmol/L).Higher overall self-care scores were significantly associated with better glycemic control(OR 0.83;95%CI 0.78-0.88;P<0.001).Dietary adherence(OR 0.72;95%CI 0.61-0.85),physical activity(OR 0.74;95%CI 0.65-0.84),and blood glucose monitoring(OR 0.22;95%CI 0.09-0.54)were significantly associated with improved glycemic outcomes.Foot care(OR 0.98;P=0.797)and medication adherence(OR 3.21;P=0.095)showed no significant association.Males,older adults(≥60 years),and Yoruba/Igbo participants had lower dietary scores,while exercise scores were higher among males,singles,and Igbo patients.Longer diabetes duration(≥20 years)was linked to better medication adherence and exercise.Conclusions Self-care behaviors were significantly associated with glycemic control among T2DM patients attending two specialized endocrinology clinics in Gusau,Nigeria.Interventions tailored to demographic and cultural contexts are essential to strengthen adherence in key areas such as diet,physical activity,and glucose monitoring.These findings underscore the importance of supporting self-management,even in patients with established access to clinical care.
基金supported by the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTD-C-202006)the High-level traditional Chinese medicine key subject construction project of National Administration of Traditional Chinese Medicine-Evidence-based Traditional Chinese Medicine(ZYYZDXK-2023249).
摘要Background:The bibliometrics of acupuncture are growing rapidly.However,the absence of reporting guidelines may lead to significant duplication and waste,thereby undermining the research’s value.To address this,a knowledge mapping was generated based on published studies to investigate the characteristics of bibliometric studies on acupuncture and the extent of duplicate publications,with the overarching goal of providing a comprehensive overview of the knowledge structure in this field.Methods:This cross-sectional study used three databases(PubMed,Web of Science,and Scopus)to identify relevant studies up to May 1,2024.In addition,the reference lists were retrieved as a supplement.To track research trends,we employed Microsoft Excel and R software to extract,code,and analyze information.Study selection,data extraction,and validation were performed independently by at least two reviewers.The reporting quality of included studies was assessed using the Preliminary guideline for reporting bibliometric reviews of the biomedical literature(BIBLIO).Results:Among the 6,221 bibliometric reviews examined,113 relevant publications were identified,80 focusing on various diseases/conditions.The annual number of publications has gradually increased,with the output in the past four years being 3.52 times higher than that before 2020.China(106)and Chengdu University of Traditional Chinese Medicine(16)have the highest number of publications.The most prolific author is Fan-Rong Liang,with six articles.The first bibliometric study,by Hai-Yan Li,was published in 2010.Journal of Pain Research,with 36 articles,holds the most publications.The top three diseases:diseases of the nervous system;symptoms,signs,or clinical findings not elsewhere classified;and mental,behavioral,or neurodevelopmental disorders.There may be potential duplication in research on 13 diseases/conditions,notably stroke,migraine,pain/analgesia,cancer pain,shoulder pain,facial paralysis/bell’s palsy,chronic pain,and cognitive impairment.In BIBLIO,the most frequently missing items are issuesopics(item 2),quality assessment(item 11),and descriptive findings(item 13).Conclusion:This study demonstrates that acupuncture bibliometrics is actively utilized to identify dominant diseases/conditions,aiding scholars in understand the knowledge structure and main topics.Although the number of related studies is increasing,with an average of 25 studies annually,overlap in some areas highlights the need for adherence to reporting guidelines and careful topic selection to ensure truly valuable insights and knowledge contributions.The adherence to BIBLIO’s 20 proposed items across analyzed articles,highlighting important in reporting practices.
摘要association with academic and clinical performance.This study aimed to determine the EI level of hospital-based nursing students and examine differences between full-time and part-time students.Methods:We conducted a cross-sectional study in a hospital-based nursing school.EI level was measured using the Schutte Self-report Emotional Intelligence Scale(SSEIS).Results:We recruited 287 participants(mean age:21.9 years).Their mean SSEIS score was 119.6(95%CI=118.57-120.65).The mean SSEIS scores of 172 full-time and 115 part-time nurses were 120.7(95%CI=119.3-122.0)and 118.1(95%CI=116.5-119.6),respectively.There was no significant difference between the groups.Conclusion:The EI difference between full-time and part-time nursing students was statistically insignificant.The need for further EI development among both full-time and part-time students must be addressed.
基金Supported by Sanming Project of Medicine in Shenzhen,No.SZZYSM202202010。
摘要BACKGROUND The triglyceride glucose-body mass index(TyG-BMI)is a novel indicator of insulin resistance(IR).Obstructive sleep apnea(OSA)is a prevalent disorder characterized by recurrent complete or partial collapse of the pharyngeal airway during sleep;however,the relationship between these two conditions remains unexplored.We hypothesized that a higher TyG-BMI is associated with the occurrence of OSA.AIM To assess the association between TyG-BMI and OSA in adults in the United States.METHODS A cross-sectional study was conducted utilizing data from the National Health and Nutrition Examination Surveys spanning from 2005-2008 to 2015-2018.TyGBMI was calculated as Ln[triglyceride(mg/dL)×fasting blood glucose(mg/dL)/2]×BMI.Restricted cubic splines were used to analyze the risk of TyG-BMI and OSA occurrence.To identify potential nonlinear relationships,we combined Cox proportional hazard regression with smooth curve fitting.We also conducted sensitivity and subgroup analyses to verify the robustness of our findings.RESULTS We included 16794 participants in the final analysis.Multivariate regression analysis showed that participants with a higher TyG-BMI had a higher OSA incidence.After adjusting for all covariates,TyG-BMI was positively correlated with the prevalence of OSA(odds ratio:1.28;95%confidence interval:1.17,1.40;P<0.001);no significant nonlinear relationship was observed.Subgroup analysis showed no strong correlation between TyG-BMI and OSA in patients with diabetes.The correlation between TyG-BMI and OSA was influenced by age,sex,smoking status,marital status,hypertensive stratification,and obesity;these subgroups played a moderating role between TyGBMI and OSA.Even after adjusting for all covariates,there was a positive association between TYG-BMI and OSA prevalence.CONCLUSION A higher TyG-BMI index is linked to higher chances of developing OSA.As TyG-BMI is an indicator of IR,managing IR may help reduce the risk of OSA.
摘要Objective:This study aimed to examine the association between parent-child relationships and physically aggressive behavior among adolescents.Methods:This is a cross-sectional study that uses secondary data from the 2015 Indonesia Global School-Based Health Survey(IGSHS).Health surveys were conducted in 75 schools representing three regions(Sumatra,Java-Bali;Outer Sumatra;and Java-Bali)in 26 provinces and 68 districts/cities in Indonesia(N=10,139 students).Students who participated were aged 12-19 years,were enrolled in public schools in the junior and high school levels.Results:It has been seen that for most middle-aged adolescents(58.7%),their parents(25%-29%)pay less attention to academic assignments(homework),problems,and use of free time.The most significant factors that influence adolescents to commit violence are smoking and consuming alcohol.Adolescents who smoke are twice as likely to commit physical violence compared with adolescents who do not smoke(OR=2.005;95%CI=1.7062-2.396).Meanwhile,adolescents who consume alcohol are 1.8 times more likely to commit physical violence compared with adolescents who do not consume alcohol(OR=1.807;95%CI=1.421-2.298).Conclusions:Through educational activities and consultations,this study’s findings are valuable for establishing parenting programs among those concerned about their children’s aggressive behavior.Meanwhile,counseling programs can be started in schools by conducting self-detection of negative adolescent behavior,such as screening for smoking,alcohol consumption,sleep issues,and attempted suicide.
摘要Arterial stiffness is considered an important indicator reflecting age-related changes in the vascular wall[1]and the risk of developing comorbidities,[2]primarily cardiovascular diseases.[3]Cardiovascular diseases remain the leading cause of death worldwide.Many factors influence the rate of arterial aging.Research results have confirmed that arterial wall stiffness increases with an increasing number of risk factors,[4]as each of them acts independently through various mechanisms,adversely affecting the structure and function of the cardiovascular system.
基金support by grants from the“Chongqing Science and Technology Benefiting project”(cstc2016kjhmpt1001)research project from the State Key Laboratory of Trauma,Burns and Combined Injury(SKLZZ201603)。
摘要Background:Since the trauma knowledge of trauma providers correlates with the outcomes of injured patients,this study aims to assess the socio-demographic characteristics and levels of trauma knowledge of trainees in the China trauma care training(CTCT)program in addition to their post-course test results to provide support for the development of trauma care training programs and trauma systems in China.Methods:A cross-sectional study was conducted by collecting demographic information,hospital-related information and trauma knowledge of the trainees from 19 regions in China.All participants were assessed by questionnaires collecting the socio-demographic data,the trauma care knowledge levels and the information of the hospitals.Results:There were 955 males(78.9%)and 256 females(21.1%)enrolled.Among them,854 were physicians(70.5%),357 were registered nurses(29.5%).In addition,64 of them also played an administrative role in the hospitals(5.3%).The score of the trainees who were members of the emergency department staff(72.59±14.13)was the highest among the scores of all the personnel surveyed,followed by those of the trainees from the intensive care unit(ICU)(71.17±12.72),trauma surgery department(67.26±13.81),orthopedics department(70.36±14.48),general surgery department(69.91±14.79)and other departments(69.93±16.91),P=0.031.The score of the professors(73.09±15.05)was higher than those of the associate professors(72.40±14.71),lecturers(70.07±14.25)and teaching assistants(67.58±15.16),P<0.0001.The score of the individuals who attended experts’trauma lectures(72.22±14.45)was higher than that of individuals who did not attend the lectures(69.33±15.17),P=0.001.The mean scores before and after the training were 71.02±14.82 and 84.24±13.77,respectively,P<0.001.The mean score of trauma knowledge after the training of trainees from different provinces and with different educational backgrounds was higher than that before the training,with a statistically significant difference(P<0.05).Conclusions:The level of trauma knowledge of trauma care providers was associated with their department,professional position and previous participation in related academic conferences.Trauma care experience and participation in academic lectures and training program including CTCT may effectively improve individuals’level of trauma knowledge.
摘要Summary:Nurses'work-related fatigue has been recognized as a threat to nurse health and patient safety.The aim of this study was to assess the prevalence of fatigue among first-line nurses combating with COVID-19 in Wuhan,China,and to analyze its influencing factors on fatigue.A multi-center,descriptive,cross-sectional design with a convenience sample was used.The statistical population consisted of the first-line nurses in 7 tertiary general hospitals from March 3,2020 to March 10,2020 in Wuhan of China.A total of 2667 samples from 2768 contacted participants completed the investgation,with a response rate of 96.35%.Social-demographic questionnaire,work-related questionnaire,Fatigue Scale-14,Generalized Anxiety Disorder-7,Patient Health Questionnaire-9,and Chinese Perceived Stress Scale were used to conduct online survey.The descriptive statistic of nurses'social-demographic characteristics was conducted,and the related variables of work,anxiety,depression,perceived stress and fatigue were analyzed by Z-tests,nonparametric test and Pearson's correlation analysis.The significant factors which resulted in nurses'fatigue were further analyzed by multiple linear regression analysis.The median score for the first-line nurses'fatigue in Wuhan was 4(2,8).The median score of physical and mental fatigue of them was 3(1,6)and 1(0,3)respectively.According to the scoring criteria,35.06%nurses(w=935)of all participants were in the fatigue status,their median score of fatigue was 10(8,11),and the median score of physical and mental fatigue of them was 7(5,8)and 3(2,4)respectively.Multiple linear regression analysis revealed the participants in the risk groups of anxiety,depression and perceived stress had higher scores on physical and mental fatigue and the statistically significant positive correlation was observed between the variables and nurses'fatigue,the frequency of exercise and nurses'fatigue had a statistically significant negative correlation,and average daily working hours had a significantly positive correlation with nurses'fatigue,and the frequency of weekly night shift had a low positive correlation with nurses'fatigue(P<0.01).There was a moderate level of fatigue among the first-line nurses fighting against COVID-19 pandemic in Wuhan,China.Government and health authorities need to formulate and take effective intervention strategies according to the relevant risk factors,and undertake preventive measures aimed at reducing health hazards due to increased work-related fatigue among first-line nurses,and to enhance their health status and provide a safe occupational environment worldwide.Promoting both medical and nursing safety while combating with the pandemic currently is warranted.