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Ecosystem management and agricultural green development in subtropical regions 认领 引用
1
作者 Jinshui Wu Tony G.O’Donnell +4 位作者 Andrew Macrae Hongsong Chen Weiguo Cheng Zhihong Xu Zhengmiao Deng 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2026年第2期399-401,共3页
The United Nations Sustainable Development Goal(SDG) 2 aims to achieve Zero Hunger by 2030.However,global hunger and food insecurity have continued to rise at an alarming rate(UN 2023).Subtropical regions are home to ... The United Nations Sustainable Development Goal(SDG) 2 aims to achieve Zero Hunger by 2030.However,global hunger and food insecurity have continued to rise at an alarming rate(UN 2023).Subtropical regions are home to more than 30% of the world's population,predominantly in developing countries where per capita farmland and food supply are only 40% of those in developed nations(FAO 2018).Meeting the Zero Hunger target amid ongoing population growth in these regions requires a substantial increase in agricultural production while minimizing soil degradation and adverse ecological impacts.This challenge is shared by many countries across South Asia,Africa,and Central and South America. 展开更多
关键词 ecosystem management developing countries subtropical regions sustainable development goal agricultural green development zero hunger sustainable development goal sdg population growth
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Using geospatial artificial intelligence to advance the Sustainable Development Goals 认领 引用
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作者 Chenzhe Fan Chunhui Wang +2 位作者 Jing Song Huilin Yu Gang Li 《Geography and Sustainability》 CSCD 2026年第3期255-259,共5页
1.Introduction Sustainable development is widely regarded as a crucial way for human civilization to survive.To operationalize sustainability across social,economic,and environmental dimensions,the United Nations adop... 1.Introduction Sustainable development is widely regarded as a crucial way for human civilization to survive.To operationalize sustainability across social,economic,and environmental dimensions,the United Nations adopted the 17 Sustainable Development Goals(SDGs)and 169 targets as part of the 2030 Agenda for Sustainable Development in 2015(United Nations,2015).Until 2025,with the joint efforts of the world,SDGs have made significant progress in social resource allocation,disease prevention and control,and energy transformation,but the current rate of change remains insufficient to achieve all SDGs in 2030(United Nations Department of Economic and Social Affairs,2025).How to accelerate the high-quality implementation of SDGs,with only four years left until 2030,is one of the core issues in current sustainable development research. 展开更多
关键词 sustainable development geospatial artificial intelligence disease prevention control sustainable development goals energy transformation social resource allocation sustainable development goals sdgs high quality implementation
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Health-related physical fitness in children and adolescents and the United Nations Sustainable Development Goals:Signals of convergence 认领 引用
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作者 Diego Augusto Santos Silva Mark S.Tremblay 《Journal of Sport and Health Science》 SCIE CAS CSCD 2026年第3期6-12,共7页
1.Background The United Nations(UN)2030 Agenda for Sustainable Development,adopted in 2015,established the Sustainable Development Goals(SDGs)as a comprehensive framework to address global challenges through interconn... 1.Background The United Nations(UN)2030 Agenda for Sustainable Development,adopted in 2015,established the Sustainable Development Goals(SDGs)as a comprehensive framework to address global challenges through interconnected social,economic,and environmental targets. 展开更多
关键词 sustainable development goals sdgs sustainable developmentadopted agenda children adolescents address global challenges united nations sustainable development goals
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Africa’s Economic Development Amidst Profound Changes:Characteristics,Challenges and Prospects 认领 引用
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作者 Tian Feng 《Contemporary World》 2026年第1期32-38,共7页
After the end of World War II,African countries successively gained independence and ushered in a golden age of economic development.Through the strategies of primary product exports,transitional economic policies and... After the end of World War II,African countries successively gained independence and ushered in a golden age of economic development.Through the strategies of primary product exports,transitional economic policies and import substitution development,their economic growth accelerated significantly.However,due to the limitations of these strategies,the structural problem of Africa being an exporter of cheap industrial raw materials and an importer of manufactured goods remained unresolved. 展开更多
关键词 import substitution developmenttheir import substitution development primary product exports manufactured goods economic development transitional economic policies African countries economic developmentthrough
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mTORC1 and mTORC2 synergy in human neural development, disease, and regeneration 认领 引用 被引量：2
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作者 Navroop K.Dhaliwal Julien Muffat Yun Li 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第4期1552-1553,共2页
The mechanistic target of rapamycin(m TOR) is a serinehreonine kinase that plays a pivotal role in cellular growth, proliferation, survival, and metabolism. In the central nervous system(CNS), the mTOR pathway regulat... The mechanistic target of rapamycin(m TOR) is a serinehreonine kinase that plays a pivotal role in cellular growth, proliferation, survival, and metabolism. In the central nervous system(CNS), the mTOR pathway regulates diverse aspects of neural development and function. Genetic mutations within the m TOR pathway lead to severe neurodevelopmental disorders, collectively known as “mTORopathies”(Crino, 2020). Dysfunctions of m TOR, including both its hyperactivation and hypoactivation, have also been implicated in a wide spectrum of other neurodevelopmental and neurodegenerative conditions, highlighting its importance in CNS health. 展开更多
关键词 m tor neural development mtorc central nervous system cns mtor neurodevelopmental disorders neurodegenerative conditions
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Distributions and influencing factors of selenium in soils and edible wild mushrooms and the development and utilization of high-quality wild mushrooms(Boletus,Ramaria botrytoides,Russula virescens) 认领 引用
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作者 Lei Xu Meng-sheng Zhao +5 位作者 Yan-xun Cheng Yao-tang Zhang Ji-yun Guan Fang-fang Lu Chang-wei Linghu Yong-sheng Yuan 《China Geology》 CAS CSCD 2026年第2期290-302,共13页
Selenium(Se)serves as a trace element essential for the human body owing to its significant physiological functions and extensive pharmacological effects.The Se required by the human body is primarily obtained from so... Selenium(Se)serves as a trace element essential for the human body owing to its significant physiological functions and extensive pharmacological effects.The Se required by the human body is primarily obtained from soil-derived foods.This study revealed Se-rich soils covering a certain area and Se-rich edible wild mushrooms with high Se accumulation rates in Chuxiong,central Yunnan Province,China through a geochemical survey of soil quality.Furthermore,this study investigated the Se migration and transformation mechanisms in the soil-wild mushroom system,aiming to provide a scientific basis for the development and planning of Se-rich green foods in the study area.Using the geochemical data of samples collected from topsoils,deep soils,and wild mushrooms and their root soils in Nanhua County,Chuxiong,this study analyzed the Se contents in soils and wild mushrooms and their root soils and explored the mechanisms and influencing factors of Se enrichment in wild mushrooms.The results indicate that the topsoils in the study area exhibit Se contents ranging from 0.07 mg/kg to 0.95 mg/kg,with an arithmetic average of 0.25 mg/kg.The Se-rich soils cover an area of 356 km2,which accounts for 13.07% of the total topsoil area.The wild mushrooms in the study area display Se contents varying from 0.004 mg/kg to 47.10 mg/kg,with a median of 0.977 mg/kg.The analyses of Moran’s index and semivariogram indicate that the Se content distributions in both topsoils and deep soils in the study area exhibit distinct spatial structures.Specifically,the semivariogram model for the Se content in the deep soils emerges as a Gaussian model,and the Se content exhibits a nugget-to-sill ratio of 21.72%,suggesting that the Se content in deep soils is primarily influenced by structural factors such as parent materials.Se in the soils originates primarily from soil-forming parent rocks,with the origin of the Se-rich soils closely related to Triassic black shales,thin coal seams,and metamorphic rocks in the Ailao Mountain area.The wild mushrooms in the study area enjoy significantly higher Se content than other reported naturally Se-rich agricultural products,with a Se accumulation rate of up to 92.31%and an overall over-limit ratio of Pb and Cd of merely 11.54%,suggesting that the study area has substantial potential for the development of naturally Se-rich green foods.The wild mushrooms in the study area exhibit bioconcentration factors(BCFs)of Se ranging from 0.02 to 157.00(median:4.26),with Se bioavailability decreasing in the order of Boletus edulis,Boletus aereus,Leccinum nigrescens,Ramaria botrytoides,and Russula virescens.For the Se absorption and enrichment in the wild mushrooms,the primary controlling factor is identified as the wild mushroom species.Furthermore,they are significantly influenced by the Se content in soils but are minimally affected by the physicochemical indicators of soils. 展开更多
关键词 Selenium Wild mushroom Boletus Ramaria botrytoides Russula virescens Soil Bioconcentration factor Influencing factor Nanhua County Geochemical geological survey engineering Sustainable Development Goals No.1(No Poverty) Sustainable Development Goals No.2(Zero Hunger)
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Fuel to fire:developmental niche-empowered ApoEVs unlock adult hierarchical tissue regenerative potential via mitochondrial complexⅠ-driven developmental metabolic profile 认领 引用
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作者 Yanshu Zhang Jieyun Xu +10 位作者 Yuhan Shi Yihua Cai Mixiao Gui Junlong Xue Xuan Zhou Ziqiong Qin Hongcheng Chen Guanqi Liu Songtao Shi Xueli Mao Zetao Chen 《International Journal of Oral Science》 SCIE CAS CSCD 2026年第3期442-458,共17页
Organ defects involving hierarchical tissue structures remain a major challenge due to limited regenerative capacity in adulthood.To break this bottleneck,regenerative medicine is undergoing a paradigm shift from simu... Organ defects involving hierarchical tissue structures remain a major challenge due to limited regenerative capacity in adulthood.To break this bottleneck,regenerative medicine is undergoing a paradigm shift from simulating the healing process of mature organs to reactivating re-development potential,namely developmental engineering strategy.In this study,we propose a novel paradigm based on developmental niche-empowered stem cell-derived apoptotic extracellular vesicles(DevNiche-ApoEVs),which integrates cues from both parental stem cells and their environmental niches.Using the periodontium as a classical hierarchical model,we identified developmental M2-phenotype macrophages(DevM2φ)as a key niche component that induces a developmental metabolic profile in stem cells,characterized by enhanced energy metabolism,mitochondrial homeostasis,and dominance of oxidative phosphorylation.We subsequently empowered ApoEVs with DevM2φ-mediated developmental niche to generate DevNiche-ApoEVs capable of delivering mitochondrial complex I and recapitulating the developmental metabolic profile.In vitro studies confirmed DevNiche-ApoEVs reactivated the developmental potential of adult periodontal ligament cells(PDLCs),while complex I inhibition abrogated this effect.Consistently,DevNiche-ApoEVs promoted re-development-based hierarchical periodontal regeneration by recapitulating critical developmental events in vivo.This study highlights the pivotal role of the developmental niche in hierarchical tissue regeneration and provides a promising DevNiche-ApoEVs-focused developmental engineering strategy,which offers both a solid theoretical foundation and an effective translational solution to overcome the longstanding bottleneck in adult tissue regeneration. 展开更多
关键词 apoptotic extracellular vesicles developmental niche developmental engineering strategyin organ defects mitochondrial complex I hierarchical tissue structures mature organs simulating healing process
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Effect of amoxicillin on cartilage and bone development in zebrafish and their molecular mechanisms 认领 引用 被引量：1
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作者 Fei Long Yangfan Shangguan +2 位作者 Jiaqi Wang Hui Wang Liaobin Chen 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第4期562-572,共11页
Amoxicillin,a beta-lactam antibiotic,is the preferred treatment for numerous common infections during pregnancy.However,it has been identified as an emerging environmental pollutant.Clinical and animal studies indicat... Amoxicillin,a beta-lactam antibiotic,is the preferred treatment for numerous common infections during pregnancy.However,it has been identified as an emerging environmental pollutant.Clinical and animal studies indicate that prenatal exposure to amoxicillin may pose fetal developmental toxicity risks.In view of the environmental exposure and clinical application status of amoxicillin,this study investigated the effects of amoxicillin exposure at different concentrations and embryonic stages on the overall development of zebrafish embryos,as well as the development of cartilage and bone,and their underlying mechanisms.Our findings revealed that embryonic exposure to amoxicillin inhibited the overall,cartilage,and bone development of zebrafish in a concentration(80–400μmol/L)and stage(0–1.5 and 1.5–3.0 dpf)dependent manner.This inhibition was manifested as reduced head and body length,decreased head and eye area,shortened palatal and ceratohyal cartilage length,and diminished operculum bone area,with these effects persisting from the larval to the juvenile stage.Notably,early exposure to amoxicillin had a more pronounced impact on zebrafish embryonic cartilage development,attributed to the inhibition of the foxo3a signaling pathway.In contrast,late exposure to amoxicillin more significantly affected zebrafish embryonic bone development,associated with the inhibition of the jak2a/stat3 signaling pathway.This study has verified the toxicity of amoxicillin to cartilage and bone development and elucidated its potential mechanisms,providing a theoretical and experimental basis for evaluating the environmental exposure risk of amoxicillin and revealing its action patterns. 展开更多
关键词 Amoxicillin exposure Cartilage development Bone development Zebrafish embryo Foxo3a pathway Jak2a/stat3 pathway
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Guiding the younger generation to explore new scenarios for participating in standards development and application 认领 引用
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作者 Li Zhiping 《China Standardization》 2026年第1期43-44,共2页
Standards are the common language that consolidates global consensus and builds the most solid foundation for international partnerships.They are the cornerstone for global sustainable and high-quality development.You... Standards are the common language that consolidates global consensus and builds the most solid foundation for international partnerships.They are the cornerstone for global sustainable and high-quality development.Young students,with their active and vibrant minds,represent the future and hope of standardization. 展开更多
关键词 standards development sustainable development application standards international partnerships high quality development consolidates global consensus younger generation common language
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Intersection of mitochondrial dysfunction and myelination:An overlooked aspect in neurodevelopmental disorders 认领 引用 被引量：1
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作者 Ariel Nir Sade Gal Wiener Boaz Barak 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第2期659-660,共2页
Neurodevelopmental processes represent a finely tuned interplay between genetic and environmental factors,shaping the dynamic landscape of the developing brain.A major component of the developing brain that enables th... Neurodevelopmental processes represent a finely tuned interplay between genetic and environmental factors,shaping the dynamic landscape of the developing brain.A major component of the developing brain that enables this dynamic is the white matter(WM),known to be affected in neurodevelopmental disorders(NDDs)(Rokach et al.,2024).WM formation is mediated by myelination,a multifactorial process driven by neuro-glia interactions dependent on proper neuronal functionality(Simons and Trajkovic,2006).Another key aspect of neurodevelopmental abnormalities involves neuronal dynamics and function,with recent advances significantly enhancing our understanding of both neuronal and glial mitochondrial function(Devine and Kittler,2018;Rojas-Charry et al.,2021).Energy homeostasis in neurons,attributed largely to mitochondrial function,is critical for proper functionality and interactions with oligodendrocytes(OLs),the cells forming myelin in the brain’s WM.We herein discuss the interplay between these processes and speculate on potential dysfunction in NDDs. 展开更多
关键词 neurodevelopmental disorders ndds rokach white matter developing brain myelination neurodevelopmental processes mitochondrial dysfunction white matter wm known developing braina
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Powering Local Growth China's counties are on track to witness high-quality development rooted in local conditions 认领 引用
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作者 Tu Shengwei 《China Report ASEAN》 2026年第1期50-51,共2页
County economies form a distinctive,integrated regional economic structure.Their growth is shaped by specific social and historical conditions and,in turn,influences many aspects of wider economic and social developme... County economies form a distinctive,integrated regional economic structure.Their growth is shaped by specific social and historical conditions and,in turn,influences many aspects of wider economic and social development.In China's modernization process,they have always played a vital role.The 2024 Central Economic Work Conference placed strong emphasis on vigorously developing county economies. 展开更多
关键词 county economies economic social developmentin regional economic structure high quality development economic development local growth social historical conditions vigorously developing county economies
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Morphological changes and gibberellin-related gene expression patterns during fruit growth and development of Amomum villosum 认领 引用 被引量：1
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作者 LÜ Bingding ZHANG Yuyi +5 位作者 TANG Liyun HU Jiajia SU Jing XU Jie HE Zhuohang HE Guozhen 《中山大学学报（自然科学版）（中英文）》 CAS CSCD 北大核心 2026年第3期19-32,共14页
The fruit of Amomum villosum is highly valued for its medicinal and edible properties.However,the fruit abscission rate is exceptionally high,resulting in low unit yield.To better understand the fruit growth and devel... The fruit of Amomum villosum is highly valued for its medicinal and edible properties.However,the fruit abscission rate is exceptionally high,resulting in low unit yield.To better understand the fruit growth and development,this study investigated the characteristic changes of fruits and the expression patterns of GA-related genes in both fruits and fruit stalks.Results revealed that it takes approximately 90 days for the ovary of A.villosum to reach maturity.Fruit growth pattern exhibited a slow-fast-slow trend,with the peak of fruit weight accumulation occurring between the 14 and 25 days after artificial pollination(DAP).Before the 27 DAP,significant changes were observed in the ovary,fruit color,pericarp thickness,and fruit thorn length.Additionally,ten candidate GA-related genes,including 1 GA13ox,1 GA20ox,1 GA3ox,2 GA2oxs,4 GID1cs,and 1 DELLA,were analyzed using bioinformatics tools.The GA-related genes in fruit and fruit stalk exhibited significant correlations with fruit growth/development and fruit dropping.Overall,the fruit growth and development law,and the expression patterns of GA-related genes provided a theoretical foundation for further functional study and the screening of candidate genes for potential applications in A.villosum. 展开更多
关键词 Amomum villosum gibberellin fruit development gene expression pattern bioinformatic
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Identification of GLDN^(+)odontogenic stem cells as crucial for human tooth development and regeneration 认领 引用 被引量：1
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作者 Chengcheng Liao Jinglun Liu +9 位作者 Maojiao Li Bingqian Yang Yejia Yu Jian Yang Xiaoxia Su Shixing Ma Hanchao Li Jingyi Zhang Weidong Tian Li Liao 《International Journal of Oral Science》 SCIE CAS CSCD 2026年第3期386-400,共15页
The dental papilla(DP)is essential for the development of dentin and pulp.The extensive cellular heterogeneity within the DP is a critical factor underlying the complex and precise formation of dental structures durin... The dental papilla(DP)is essential for the development of dentin and pulp.The extensive cellular heterogeneity within the DP is a critical factor underlying the complex and precise formation of dental structures during odontogenesis.However,the critical cell types within human DP that play essential role in tooth development and regeneration remain largely uncharacterized.In this study,we analyzed the heterogeneity of human DP cells using single-cell sequencing and identified Gliomedin(GLDN)+DP stem cells(DPSCs)were a group of progenitors at an early stage of tooth development and play a key role in the development of pulp and dentin.GLDN+DPSCs strategically accumulate in human DP tissue near the interface of the newly formed dentin or pulp.Functional assays demonstrated that GLDN+DPSCs exhibited enhanced self-renewal,migratory capacity,and odontogenic differentiation potential in vitro compared to GLDN-DPSCs.Moreover,GLDN+DPSCs effectively induce the migration and tube formation of endothelial cells,which are essential for tooth development.The ectopic dental pulp regeneration model confirmed that GLDN+DPSCs can regenerate a vascularized dental pulp structure with an odontoblast layer in vivo.Given their functional capabilities,this population of cells has been designated as GLDN+odontogenic stem cells(OSCs).Mechanistically,GLDN is essential for maintaining the phenotype and function of GLDN+OSCs through BMP5 signaling via autocrine and paracrine mechanisms.In conclusion,this study identifies a previously uncharacterized essential subpopulation of OSCs essential for dental pulp development and regeneration. 展开更多
关键词 dental papilla dp dental papilla cell types development dentin pulpthe cellular heterogeneity gliomedin self renewal single cell sequencing
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Evaluating the coordination between conservation and development on the Qinghai-Tibet Plateau through a dual-dimensional framework 认领 引用
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作者 WEN Ningning YANG Hua +2 位作者 SUN Yong CHEN Shaofeng ZHANG Conglin 《Journal of Geographical Sciences》 SCIE CSCD 2026年第4期919-942,共24页
Coordinating socioeconomic development and environmental conservation is essential for ensuring sustainable development.Previous studies have primarily focused on evaluating key dimensions of coordination,i.e.,perform... Coordinating socioeconomic development and environmental conservation is essential for ensuring sustainable development.Previous studies have primarily focused on evaluating key dimensions of coordination,i.e.,performance alignment and progress synchronization,in isolation,thus limiting a comprehensive understanding.Assessment methods also face limitations because of the lack of reliable and comparable performance evaluation criteria,insufficient differentiation in coordination measurement,and symmetry issues that conceal distinct coordination patterns.To address these gaps,a dual-dimensional coordination analytical framework is developed in which Sustainable Development Goals(SDG)-based criteria and refined coordination measurement methods are incorporated.Application of this framework to the Qinghai-Tibet Plateau reveals that environmental and socioeconomic goal achievement increased by 15%from 2000 to 2020,reaching 59%and 41%,respectively.The degree of performance alignment remained moderate,and progress synchronization was generally high,with both improving over time despite persistent regional disparities.Under the assumption of SDG achievement by 2030,projections indicate that only counties on the eastern plateau and in parts of Lhasa are likely to sustain coordinated progress,while 51%of counties face dual-dimensional coordination challenges,which poses barriers to SDG attainment.These findings highlight the need for phased and region-specific policy strategies.This framework provides a systematic approach for analysing coordination challenges and guiding policy formulation,with broader applicability across regions. 展开更多
关键词 Sustainable Development Goals coordinated development performance alignment progress synchronization Qinghai-Tibet Plateau
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The ultra-conserved lncRNA Crnde regulates neural differentiation by targeting Gbx2 during embryonic development of the thalamus 认领 引用
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作者 Wen-Zhu Hu Ya-Yun Gu +8 位作者 Yuan-Lin He Yuan Hong Yue-Wen He Zi-Cheng Zhang Yuan-Hao Wang Jia-Ning Sun Xiao Han Yan Liu Zhi-Bin Hu 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2026年第7期1248-1265,共18页
The thalamus regulates sensory processing,cognition,and sleep,yet the molecular mechanisms underlying its development remain incompletely understood.Long noncoding RNAs(lncRNAs),particularly evolutionarily conserved o... The thalamus regulates sensory processing,cognition,and sleep,yet the molecular mechanisms underlying its development remain incompletely understood.Long noncoding RNAs(lncRNAs),particularly evolutionarily conserved ones,are highly enriched in the brain.Using public mRNA databases,we screen for lncRNAs with embryonic brain expression and harboring ultraconserved noncoding elements(UCNEs)in humans and mice,identifying colorectal neoplasia differentially expressed(Crnde).It exhibits stage-specific upregulation in the embryonic thalamus.The Database of Genomic Variation and Phenotype in Humans using Ensembl Resources(DECIPHER)suggests a potential association between Crnde and intellectual disability.Crnde-deficient mice display anxiety-like behaviors and spatial memory deficits.Furthermore,Crnde ablation increases progenitor cell numbers and impairs neuronal differentiation during embryonic thalamic development.Mechanistically,Crnde modulates the mRNA expression of gastrulation brain homeobox 2(Gbx2),a gene critical for thalamic development.Collectively,our results implicate lncRNA Crnde in the proper progression of embryonic thalamic development in mice. 展开更多
关键词 Neurodevelopmental disorders Intellectual disability Long noncoding RNA Crnde Thalamus development Neuronal differentiation
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Profiling and functional characterization of long noncoding RNAs during human tooth development 认领 引用 被引量：2
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作者 Xiuge Gu Wei Wei +11 位作者 Chuan Wu Jing Sun Xiaoshan Wu Zongshan Shen Hanzhang Zhou Chunmei Zhang Jinsong Wang Lei Hu Suwen Chen Yuanyuan Zhang Songlin Wang Ran Zhang 《International Journal of Oral Science》 SCIE CAS CSCD 2025年第4期505-516,共12页
The regulatory processes in developmental biology research are significantly influenced by long non-coding RNAs(lncRNAs).However,the dynamics of lncRNA expression during human tooth development remain poorly understoo... The regulatory processes in developmental biology research are significantly influenced by long non-coding RNAs(lncRNAs).However,the dynamics of lncRNA expression during human tooth development remain poorly understood.In this research,we examined the lncRNAs present in the dental epithelium(DE)and dental mesenchyme(DM)at the late bud,cap,and early bell stages of human fetal tooth development through bulk RNA sequencing.Developmental regulators co-expressed with neighboring lncRNAs were significantly enriched in odontogenesis.Specific lncRNAs expressed in the DE and DM,such as PANCR,MIR205HG,DLX6-AS1,and DNM3OS,were identified through a combination of bulk RNA sequencing and single-cell analysis.Further subcluster analysis revealed lncRNAs specifically expressed in important regions of the tooth germ,such as the inner enamel epithelium and coronal dental papilla(CDP).Functionally,we demonstrated that CDP-specific DLX6-AS1 enhanced odontoblastic differentiation in human tooth germ mesenchymal cells and dental pulp stem cells.These findings suggest that lncRNAs could serve as valuable cell markers for tooth development and potential therapeutic targets for tooth regeneration. 展开更多
关键词 long noncoding RNAs dental mesenchyme developmental biology dental mesenchyme dm dental epithelium de bulk rna sequencingdevelopmental regulators human tooth development tooth development
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Potential role of astrocyte on gamma-aminobutyric acid tone regulation during developmental period 认领 引用
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作者 Erva Ozkan Wuhyun Koh 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第3期1118-1119,共2页
The early developmental period is a critical window during which brain cells mature and contribute to both brain development and later life functions.Gamma-aminobutyric acid(GABA),recognized as a major neurotransmitte... The early developmental period is a critical window during which brain cells mature and contribute to both brain development and later life functions.Gamma-aminobutyric acid(GABA),recognized as a major neurotransmitter,plays a crucial role in coordinating synapse formation,neuronal proliferation,and migration during this time. 展开更多
关键词 early developmental period developmental period brain cells neuronal proliferation synapse formation gamma aminobutyric acid astrocyte GABA
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Mapping global floodplain development disparities highlights drivers behind intensifying flood losses 认领 引用
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作者 Zhiyang Lan Wenbin Liu +14 位作者 Rafael Jan Pablo Schmitt Chaoyang Wu Yingjie Li Deliang Chen Peirong Lin Kailiang Yu Xinli Bai Kaihao Zheng Tingting Wang Hong Wang Youcun Qi Wei Liang Yao Feng Ning Wang Fubao Sun 《Science Bulletin》 SCIE EI CAS CSCD 2026年第12期3097-3106,共10页
Floodplains attract disproportionate concentrations of population and economic activity globally,yet the systemic flood risks emerging from this uneven development remain insufficiently characterized.Through a global ... Floodplains attract disproportionate concentrations of population and economic activity globally,yet the systemic flood risks emerging from this uneven development remain insufficiently characterized.Through a global analysis spanning 2000-2020,we quantify floodplain development patterns and associated flood losses across nations with varying socio-economic statuses and flood protection levels.Our results reveal that floodplains have experienced faster growth than non-floodplains in both population density and GDP density.These trends show significant variation depending on income and flood protection levels,revealing a divergent risk pattern:wealthier,well-protected nations accumulate greater economic assets at risk,whereas poorer,under-protected nations concentrate larger populations at risk.Furthermore,the sensitivity of flood-induced economic damages to floodplain GDP growth is more pronounced in wealthier nations,whereas the sensitivity of flood-induced fatalities to floodplain population growth is higher in poorer nations.This underscores the distinct economic vulnerability of developed nations and the human vulnerability of developing nations in the face of flooding.Based on these findings,we argue for prioritizing economic resilience and the decoupling of economic development from flood-prone asset accumulation in higher-income nations,while simultaneously emphasizing humanitarian protection and equitable infrastructure investment in lower-income nations. 展开更多
关键词 Floodplain Socio-economic development Exposure Flood losses
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Recent advances in antiviral drugs for Chikungunya virus(CHIKV):Targets,mechanisms,and development strategies 认领 引用
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作者 Xiaowen Jiang Yudan Zhao +2 位作者 Hongyuan Lu Keqiang Li Huiyuan Gao 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2026年第6期3257-3291,共35页
Chikungunya virus(CHIKV),an alphavirus transmitted by Aedes mosquitoes,has frequently caused outbreaks in tropical and subtropical regions worldwide,posing a significant public health threat.CHIKV infection leads to c... Chikungunya virus(CHIKV),an alphavirus transmitted by Aedes mosquitoes,has frequently caused outbreaks in tropical and subtropical regions worldwide,posing a significant public health threat.CHIKV infection leads to chikungunya fever,characterized by fever,rash,and persistent joint pain,with approximately 30%-40%of patients developing chronic arthritis that severely impacts quality of life.Currently,no specific antiviral drugs or vaccines against CHIKV have been approved for clinical use,highlighting the urgency of drug development.This review systematically summarizes recent progress in antiviral research on CHIKV,focusing on key target proteins in the viral life cycle,such as nonstructural proteins nsP1,nsP2,nsP3,nsP4,and structural protein E1-E2 complexes,as well as the mechanisms of action of their inhibitors.We analyze the current research status of various anti-CHIKV compounds,including suramin,baicalin,halofuginone,betulinic acid,andrographolide,and itraconazole.Additionally,we summarize host-directed antiviral strategies targeting pathways such as host cell oxidative folding,Na+/K+-ATPase,and MAPK signaling.This review aims to establish a theoretical foundation and outline potential research directions for the development of CHIKV-related therapeutics,thereby facilitating the discovery of effective treatment strategies against this pathogen. 展开更多
关键词 Chikungunya virus Antiviral drugs Viral targets Host targets Drug development Mechanisms of action
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Regulation of maize kernel development via divergent activation ofα-zein genes by transcription factors O11,O2,and PBF1 认领 引用
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作者 Runmiao Tian Zeyuan Yang +7 位作者 Ruihua Yang Sihao Wang Qingwen Shen Guifeng Wang Hongqiu Wang Qingqian Zhou Jihua Tang Zhiyuan Fu 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2026年第1期154-162,共9页
α.-Zeins,the major maize endosperm storage proteins,are transcriptionally regulated by Opaque2(O2)and prolamin-box-binding factor 1(PBF1),with Opaque11(O11)functioning upstream of them.However,whether O11 directly bi... α.-Zeins,the major maize endosperm storage proteins,are transcriptionally regulated by Opaque2(O2)and prolamin-box-binding factor 1(PBF1),with Opaque11(O11)functioning upstream of them.However,whether O11 directly binds toα-zein genes and its regulatory interactions with O2 and PBF1 remain unclear.Using the small-kernel mutant sw1,which exhibits decreased 19-kDa and increased 22-kDaα-zein,we positionally clone O11 and find it directly binds to G-box/E-box motifs.O11 activates 19-kDaα-zein transcription,stronger than PBF1 but weaker than O2.Notably,PBF1 competitively binds to an overlapping E-box/P-box motif,and represses O11-mediated transactivation.Although O11 does not physically interact with O2,it participates in the O2-centered hierarchical network to enhanceα-zein expression.sw1 o2 and sw1 pbf1 double mutants exhibit smaller,more opaque kernels with further reduced 19-kDa and 22-kDaα-zeins compared to the single mutants,suggesting distinct regulatory effects of these transcription factors on 19-kDa and 22-kDaα-zein genes.Promoter motif analysis suggests that O11,PBF1,and O2 directly regulate 19-kDaα-zein genes,while O11 indirectly controls 22-kDaα-zein genes via O2 and PBF1 modulation.These findings identify the unique and coordinated roles of O11,O2,and PBF1 in regulatingα.-zein genes and kernel development. 展开更多
关键词 Maize α-Zein Kernel development Endosperm 011 O2 PBF1
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