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Experimental Validation of a Fully Coupled Frequency-Domain Method for Global Response Analysis of Floating Wind Turbines 认领 引用
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作者 CHEN Peng LI Chang-en +3 位作者 DENG Shi CHENG Zheng-shun Gareth ERFORT HU Zhi-qiang 《China Ocean Engineering》 SCIE EI CSCD 2026年第2期250-260,共11页
The design of floating wind turbines(FWTs)requires comprehensive consideration of complex marine environments and coupled responses among various components.The efficiency of current time domain simulation methods rem... The design of floating wind turbines(FWTs)requires comprehensive consideration of complex marine environments and coupled responses among various components.The efficiency of current time domain simulation methods remains insufficient for design and optimization in the early stages of FWT development.This study validates a proposed frequency domain(FD)modeling method through code-to-experiment comparison.The FD method incorporates fundamental assumptions about the FWT model,including representing the FWT tower as a nonlinear beam and modeling the rotor-nacelle assembly(RNA)and floating platform as rigid bodies positioned at each end of the tower.The method incorporates excitation loads using blade element momentum theory,linear potential flow theory,and quasistatic catenary theory for aerodynamic,hydrodynamic,and mooring dynamics,respectively.Validation involves a code-to-experiment comparison through a basin model test utilizing a 1/50 scaled semi-submersible platform equipped with a 5MW wind turbine.The results demonstrate strong correlation with experimental data regarding mean response and power spectral density of platform and nacelle motions.The overall discrepancy for these physical quantities remains below 10%.Specifically,the mean discrepancy of platform surge and pitch motions under combined wind and wave conditions measures 1.05%and 3.91%,respectively.This validation confirms the viability of the proposed FD method,offering substantial technical support for early-phase analysis and optimization of FWT.The validation results contribute significantly to advancing FWT design and optimization understanding. 展开更多
关键词 floating wind turbine frequency-domain wave basin experiment experiment validation
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Mechanism of Qigu capsule (芪骨胶囊) as a treatment for sarcopenia based on network pharmacology and experimental validation 认领 引用 被引量：2
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作者 SHI Jinyu PAN Fuwei +2 位作者 GE Haiya YANG Zongrui ZHAN Hongsheng 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2025年第2期399-407,共9页
OBJECTIVE:To explore the potential molecular mechanism of Qigu capsule(芪骨胶囊,QGC) in the treatment of sarcopenia through network pharmacology and to verify it experimentally.METHODS:The active compounds of QGC and ... OBJECTIVE:To explore the potential molecular mechanism of Qigu capsule(芪骨胶囊,QGC) in the treatment of sarcopenia through network pharmacology and to verify it experimentally.METHODS:The active compounds of QGC and common targets between QGC and sarcopenia were screened from databases.Then the herbs-compounds-targets network,and protein-protein interaction(PPI) network was constructed.Gene ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway enrichment analysis were performed by R software.Next,we used a dexamethasone-induced sarcopenia mouse model to evaluate the anti-sarcopenic mechanism of QGC.RESULTS:A total of 57 common targets of QGC and sarcopenia were obtained.Based on the enrichment analysis of GO and KEGG,we took the phosphatidylinositol 3-kinase(PI3K)/protein kinase B(Akt) signaling pathway as a key target to explore the mechanism of QGC on sarcopenia.Animal experiments showed that QGC could increase muscle strength and inhibit muscle fiber atrophy.In the model group,the expression of muscle ring finger-1 and Atrogin-1 were increased,while myosin heavy chain was decreased,QGC treatment reversed these changes.Moreover,compared with the model group,the expressions of pPI3K,p-Akt,p-mammalian target of rapamycin and pForkhead box O3 in the QGC group were all upregulated.CONCLUSION:QGC exerts an anti-sarcopenic effect by activating PI3K/Akt signaling pathway to regulate skeletal muscle protein metabolism. 展开更多
关键词 sarcopenia Network pharmacology experimental validation phosphatidylinositol 3-kinase proto-oncogene proteins c-akt signal transduction Qigu capsule
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Unveiling the therapeutic mechanism of Epimedium Herba on prostate cancer through network pharmacology and experimental validation 认领 引用 被引量：1
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作者 Zhiliang Xiao Sicong Jiang +3 位作者 Shengqiang Fu Xiaohai Zhang Xueliang Qi Changhao Li 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2025年第12期59-68,共10页
Epimedium Herba(EH)demonstrates significant therapeutic potential against prostate cancer(PC),though its mechanisms of action remain incompletely understood.This study investigates the pharmacological mechanisms of EH... Epimedium Herba(EH)demonstrates significant therapeutic potential against prostate cancer(PC),though its mechanisms of action remain incompletely understood.This study investigates the pharmacological mechanisms of EH in treating PC through network pharmacology analysis and experimental validation.Active components and potential targets of EH were identified using network pharmacology from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP).The STRING database facilitated the construction of a protein-protein interaction(PPI)network for shared targets and the identification of core anti-PC targets.Messenger ribonucleic acid(mRNA)and protein expression of core target genes in normal prostate and PC tissues,along with their correlation to overall PC survival,were analyzed using The Cancer Genome Atlas(TCGA),Human Protein Atlas(HPA),and Gene Expression Profiling Interactive Analysis(GEPIA)databases.Gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analyses were performed on the potential targets.Molecular docking of quercetin with key targets(TP53,TNF,heat shock protein 90 alpha family class A member 1(HSP90 AA1),AKT1,CASP3,and ESR1)was conducted,with results visualized using PyMOL.In vitro experiments validated the network pharmacology predictions.Twenty-three active ingredients of EH were identified,and the intersection of potential targets with PC targets yielded 183 potential targets.PPI network analysis revealed six key genes:targets(TP53),TNF,HSP90 AA1,AKT1,CASP3,and ESR1.GO enrichment analysis identified 2369 biological processes(BP),77 cellular components(CC),and 215 molecular functions(MF).KEGG pathway enrichment analysis demonstrated that EH's anti-cancer effects were mediated through interleukin-17(IL-17),TNF,phosphatidylinositol 3-kinase(PI3K)-AKT,apoptosis,p53,HIF-1,mitogen-activated protein kinase(MAPK),nuclear factorκB(NF-κB),and EGFR tyrosine kinase inhibitor resistance pathways.Core target validation confirmed consistency with the study's findings.Molecular docking indicated stable binding between the six core targets and quercetin.In vitro experiments confirmed quercetin's inhibition of proliferation and induction of apoptosis in ACT-1 cells.This investigation identifies potential therapeutic targets for PC through network pharmacology and experimental validation.resistance,and enhancing patient prognosis. 展开更多
关键词 Network pharmacology Epimedium Herba Prostate cancer Molecular docking Experimental validation
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Correction:Investigation on the mechanism of Qi-Hong-Tang-Zu ointment in thetreatmentofdiabetic wound by network pharmacology and experimental validation 认领 引用
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《Traditional Medicine Research》 2025年第12期73-74,共2页
Traditional Medicine Research published an article entitled Investigation on the mechanism of Qi-Hong-Tang-Zu ointment in thetreatmentofdiabetic wound by network pharmacology and experimental validation on 24 January ... Traditional Medicine Research published an article entitled Investigation on the mechanism of Qi-Hong-Tang-Zu ointment in thetreatmentofdiabetic wound by network pharmacology and experimental validation on 24 January 2025.The author confirmed this article’s proof on 23 January 2025 without any questions.But on 06 July 2025,the editorial team found,there was an error in Figure 8.Specifically,Figure 8E,Figure 8F and Figure 8G were mistakenly duplicated.The authors acknowledge that the original version of Figure 8 was incorrect and have provided the revised,correct version in this corrigendum.The authors would like to assert that there is no change in the body text of the article. 展开更多
关键词 network pharmacology experimental validation Qi Hong Tang Zu ointment diabetic wound
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Mechanisms of Forsythia suspensa Extract Against IgA Nephropathy through Network Pharmacology and Experimental Validation 认领 引用
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作者 Yali Xi Yawen Bai 《Chinese Medicine and Natural Products》 CAS 2025年第3期180-192,共13页
Objective Forsythia suspensa has long been utilized in traditional Chinese medicine(TCM)for the treatment of IgA nephropathy(IgAN),the most prevalent form of primary glomerular disease.However,the precise mechanisms r... Objective Forsythia suspensa has long been utilized in traditional Chinese medicine(TCM)for the treatment of IgA nephropathy(IgAN),the most prevalent form of primary glomerular disease.However,the precise mechanisms remain inadequately understood.This study seeks to elucidate the underlying mechanisms of Forsythia suspensa extract(FSE)in the treatment of IgAN by employing an integrated approach that combines network pharmacology with in vivo experimental validation.Methods The chemical components of FSE were identified using high-performance liquid chromatography-mass spectrometry(HPLC–MS/MS).Additional chemical components and targets were determined through the Traditional Chinese Medicine Systems Pharmacology database.Potential therapeutic targets for IgAN were sourced from GeneCards and the Comparative Toxicogenomics Database.Subsequently,the enrichment analyses were conducted to evaluate the biological functions and pathways associated with the core targets.Finally,a mousemodel of IgAN was developed to validate the findings of the network pharmacology analysis.Results Through network analysis and HPLC–MS/MS,31 chemical components of FSE were identified.A total of 99 common targets were discovered between FSE and IgAN.The enrichment analyses suggested that FSE may mitigate IgAN primarily by inhibiting the TLR and NF-κB signaling pathways.In vivo experiments demonstrated that FSE reduced inflammation and preserved renal function in mice with IgAN through the Tolllike receptor 9(TLR9)/NF-κB pathway.Conclusion The integration of network pharmacology and animal experiments suggests that FSE alleviates renal inflammation and damage in IgAN through the TLR9/NF-κB signaling pathway. 展开更多
关键词 Forsythia suspensa extract IgA nephropathy TLR9/NF-κB signaling pathway network pharmacology experimental validation
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Network pharmacology and experimental validation of Maxing Shigan decoction in the treatment of influenza virus-inducedferroptosis 认领 引用 被引量：6
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作者 HUANG Jiawang MA Xinyue +6 位作者 LIAO Zexuan LIU Zhuolin WANG Kangyu FENG Zhiying NING Yi LU Fangguo LI Ling 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2023年第10期775-788,共14页
Influenza is an acute viral respiratory infection that has caused high morbidity and mortality worldwide.Influenza A virus(IAV)has been found to activate multiple programmed cell death pathways,including ferroptosis.F... Influenza is an acute viral respiratory infection that has caused high morbidity and mortality worldwide.Influenza A virus(IAV)has been found to activate multiple programmed cell death pathways,including ferroptosis.Ferroptosis is a novel form of programmed cell death in which the accumulation of intracellular iron promotes lipid peroxidation,leading to cell death.However,little is known about how influenza viruses induce ferroptosis in the host cells.In this study,based on network pharmacology,we predicted the mechanism of action of Maxing Shigan decoction(MXSGD)in IAV-induced ferroptosis,and found that this process was related to biological processes,cellular components,molecular function and multiple signaling pathways,where the hypoxia inducible factor-1(HIF-1)signaling pathway plays a significant role.Subsequently,we constructed the mouse lung epithelial(MLE-12)cell model by IAV-infected in vitro cell experiments,and revealed that IAV infection induced cellular ferroptosis that was characterized by mitochondrial damage,increased reactive oxygen species(ROS)release,increased total iron and iron ion contents,decreased expression of ferroptosis marker gene recombinant glutathione peroxidase 4(GPX4),increased expression of acyl-CoA synthetase long chain family member 4(ACSL4),and enhanced activation of hypoxia inducible factor-1α(HIF-1α),induced nitric oxide synthase(iNOS)and vascular endothelial growth factor(VEGF)in the HIF-1 signaling pathway.Treatment with MXSGD effectively reduced intracellular viral load,while reducing ROS,total iron and ferrous ion contents,repairing mitochondrial results and inhibiting the expression of cellular ferroptosis and the HIF-1 signaling pathway.Finally,based on animal experiments,it was found that MXSGD effectively alleviated pulmonary congestion,edema and inflammation in IAV-infected mice,and inhibited the expression of ferroptosis-related protein and the HIF-1 signaling pathway in lung tissues. 展开更多
关键词 Network pharmacology Experimental validation Maxing Shigan decoction Influenza Ferroptosis HIF-1 signaling pathway
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A Train-Bridge Dynamic Interaction Analysis Method and Its Experimental Validation 认领 引用 被引量：19
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作者 Nan Zhang Yuan Tian He Xia 《Engineering》 SCIE EI CAS 2016年第4期528-536,共9页
The train-bridge dynamic interaction problem began with the development of railway technology, and requires an evaluation method for bridge design in order to ensure the safety and stability of the bridge and the runn... The train-bridge dynamic interaction problem began with the development of railway technology, and requires an evaluation method for bridge design in order to ensure the safety and stability of the bridge and the running train. This problem is studied using theoretical analysis, numerical simulation, and experimental study. In the train-bridge dynamic interaction system proposed in this paper, the train vehicle model is established by the rigid-body dynamics method, the bridge model is established by the finite element method, and the wheelail vertical and lateral interaction are simulated by the corresponding assumption and the Kalker linear creep theory, respectively. Track irregularity, structure deformation, wind load, collision load, structural damage, foundation scouring, and earthquake action are regarded as the excitation for the system. The train-bridge dynamic interaction system is solved by inter-history iteration. A case study of the dynamic response of a CRH380BL high-speed train running through a standard-design bridge in China is discussed. The dynamic responses of the vehicle and of the bridge subsystems are obtained for speeds ranging from 200 km-b-1 to 400 km.h-1, and the vibration mechanism are analyzed. 展开更多
关键词 Train-bridge dynamic interaction Wheelail relationship Inter-history iteration Field measurement Experimental validation
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Prediction of ground-borne vibration induced by impact pile driving:numerical approach and experimental validation 认领 引用 被引量：4
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作者 A.Colaço P.Alves Costa +2 位作者 C.Ferreira C.Parente J.Fernandez-Ruiz 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2023年第4期921-935,共15页
Deep foundations are currently used in engineering practice to solve problems caused by weak geotechnical characteristics of the ground.Impact pile driving is an interesting and viable solution from economic and techn... Deep foundations are currently used in engineering practice to solve problems caused by weak geotechnical characteristics of the ground.Impact pile driving is an interesting and viable solution from economic and technical points of view.However,it is necessary to ensure that the environmental drawbacks,namely ground-borne vibration,are adequately met.For this purpose,the authors propose an axisymmetric finite element method-perfectly matched layer(FEM-PML)approach,where the nonlinear behavior of the soil is addressed through an equivalent linear methodology.Given the complexity of the problem,an experimental test site was developed and fully characterized.The experimental work comprised in-situ and laboratory soil characterization,as well as the measurement of vibrations induced during pile driving.The comparison between experimental and numerical results demonstrated a very good agreement,from which it can be concluded that the proposed numerical approach is suitable for the prediction of vibrations induced by impact pile driving.The experimental database is available as supplemental data and may be used by other researchers in the validation of their prediction models. 展开更多
关键词 pile driving ground-borne vibrations numerical modeling experimental validation
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Configuration design,energy management and experimental validation of a novel series-parallel hybrid electric transit bus 认领 引用 被引量：4
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作者 Wei-wei XIONG Yong ZHANG Cheng-liang YIN 《Journal of Zhejiang University-SCIENCE A》 SCIE EI CAS 2009年第9期1269-1276,共8页
This paper aims to present the configuration design approach and the energy management strategy （EMS） of a series-parallel hybrid electric transit bus （SPHEB） jointly developed by Shanghai Automotive Industry Co. ... This paper aims to present the configuration design approach and the energy management strategy （EMS） of a series-parallel hybrid electric transit bus （SPHEB） jointly developed by Shanghai Automotive Industry Co. Ltd. （SAIC） and Shanghai Jiao Tong University （SJTU）, China. A major feature of this SPHEB is that a novel manual transmission is designed to switch the powertrain configuration between series and parallel types. To reduce the fuel consumption as well as sustain the battery state of charge, an EMS including seven energy flow modes is designed and applied to this SPHEB. Governed by this EMS, the engine is maintained to operate in high efficiency regions. The experimental test carded on the transit bus city driving cycle is described and analyzed. The experimental results demonstrate the technical feasibility and fuel economy of this approach. 展开更多
关键词 Series-parallel hybrid bus Powertrain configuration Energy management Experimental validation
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Exploring Xiaojianzhong decoction's potential in gastric cancer treatment:Integrative insights and experimental validation 认领 引用 被引量：1
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作者 Chun-Han Cheng Wen-Rui Hao Tzu-Hurng Cheng 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第12期4553-4558,共6页
Gastric cancer(GC)remains a formidable global health concern with significant morbidity and mortality rates,despite the fact that numerous advances have been made to improve conventional therapies.Xiaojianzhong decoct... Gastric cancer(GC)remains a formidable global health concern with significant morbidity and mortality rates,despite the fact that numerous advances have been made to improve conventional therapies.Xiaojianzhong decoction(XJZ),a traditional Chinese medicine,has garnered academic attention as a multicomponent,multitarget approach to managing GC.The present editorial explores the potential of XJZ in the treatment of GC through a comprehensive analysis of network pharmacology and experimental validation.Network pharmacology was used to identify key molecular targets of XJZ,including interleukin 6,prostaglandin-endoperoxide synthase 2,and matrix metalloproteinase 9,and in vitro experiments were used to confirm the efficacy of XJZ in inhibiting cell proliferation,inducing apoptosis,and modulating gene expression associated with GC progression.This editorial highlights XJZ as a promising therapeutic strategy for GC and indicates a need for further clinical exploration and validation of its efficacy. 展开更多
关键词 Xiaojianzhong decoction Gastric cancer Network pharmacology Traditional Chinese medicine Experimental validation
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Experimental validation method of elastic thin rod model for simulating the motional cable harness 认领 引用
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作者 王春生 刘检华 +1 位作者 宁汝新 陈涛 《Journal of Beijing Institute of Technology》 EI CAS 2012年第2期192-197,共6页
To analyze the spring disturbance torque caused by motionai cable harness in a stabilized platform, the Kirchhoff theory based cable harness model has been previously developed to dynamically simulate the motional cab... To analyze the spring disturbance torque caused by motionai cable harness in a stabilized platform, the Kirchhoff theory based cable harness model has been previously developed to dynamically simulate the motional cable harness. In this paper, this model was validated by comparing the simulation results with the experiment results （ both the spring force and the deformed profile of the motional cable harness）. In the experiment, a special optical measuring instrument based on binocular vision was developed and the motion and deformation of cable harness were measured. A simpli- fied stabilized platform system was constructed, and the absolute value of spring disturbance force during the motion of this simplified frame was obtained by using a force gauge （0. 02 N precision）. The physical parameters of experimental specimen were also measured. The experimental and simulated results showed good agreement. These results should be useful for better motional cable harness layout design and reliable evaluation of the spring disturbance torque. 展开更多
关键词 experimental validation method binocular vision motional cable simulation Kirchhoffrod
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Adaptive Robust Servo Control for Vertical Electric Stabilization System of Tank and Experimental Validation 认领 引用 被引量：6
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作者 Darui Lin Xiuye Wang +1 位作者 Yimin Wang Guolai Yang 《Defence Technology（防务技术）》 SCIE EI CAS CSCD 2024年第1期326-342,共17页
A tracking stability control problem for the vertical electric stabilization system of moving tank based on adaptive robust servo control is addressed.This paper mainly focuses on two types of possibly fast timevaryin... A tracking stability control problem for the vertical electric stabilization system of moving tank based on adaptive robust servo control is addressed.This paper mainly focuses on two types of possibly fast timevarying but bounded uncertainty within the vertical electric stabilization system:model parameter uncertainty and uncertain nonlinearity.First,the vertical electric stabilization system is constructed as an uncertain nonlinear dynamic system that can reflect the practical mechanics transfer process of the system.Second,the dynamical equation in the form of state space is established by designing the angular tracking error.Third,the comprehensive parameter of system uncertainty is designed to estimate the most conservative effects of uncertainty.Finally,an adaptive robust servo control which can effectively handle the combined effects of complex nonlinearity and uncertainty is proposed.The feasibility of the proposed control strategy under the practical physical condition is validated through the tests on the experimental platform.This paper pioneers the introduction of the internal nonlinearity and uncertainty of the vertical electric stabilization system into the settlement of the tracking stability control problem,and validates the advanced servo control strategy through experiment for the first time. 展开更多
关键词 Adaptive robust servo control Experimental validation Nonlinearity compensation System uncertainty Vertical electric stabilization system
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An internal ballistic model of electromagnetic railgun based on PFN coupled with multi-physical field and experimental validation 认领 引用 被引量：5
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作者 Benfeng Gu Haiyuan Li Baoming Li 《Defence Technology（防务技术）》 SCIE EI CAS CSCD 2024年第2期254-261,共8页
To accelerate the practicality of electromagnetic railguns,it is necessary to use a combination of threedimensional numerical simulation and experiments to study the mechanism of bore damage.In this paper,a three-dime... To accelerate the practicality of electromagnetic railguns,it is necessary to use a combination of threedimensional numerical simulation and experiments to study the mechanism of bore damage.In this paper,a three-dimensional numerical model of the augmented railgun with four parallel unconventional rails is introduced to simulate the internal ballistic process and realize the multi-physics field coupling calculation of the rail gun,and a test experiment of a medium-caliber electromagnetic launcher powered by pulse formation network(PFN)is carried out.Various test methods such as spectrometer,fiber grating and high-speed camera are used to test several parameters such as muzzle initial velocity,transient magnetic field strength and stress-strain of rail.Combining the simulation results and experimental data,the damage condition of the contact surface is analyzed. 展开更多
关键词 Internal ballistic modeling Electromagnetic rail gun Multi-physics field coupling Experimental validation PFN
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ProstaNet:A Novel Geometric Vector Perceptrons-Graph Neural Network Algorithm for Protein Stability Prediction in Single-and Multiple-Point Mutations with Experimental Validation 认领 引用
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作者 Tianjian Liang Ze-Yu Sun +4 位作者 Rieko Ishima Xiang-Qun Xie Ying Xue Wei Li Zhiwei Feng 《Research》 SCIE EI CSCD 2026年第1期303-314,共12页
Proteins play a critical role in biology and biopharma due to their specificity and minimal side effects.Predicting the effects of mutations on protein stability is vital but experimentally challenging.Deep learning o... Proteins play a critical role in biology and biopharma due to their specificity and minimal side effects.Predicting the effects of mutations on protein stability is vital but experimentally challenging.Deep learning offers an efficient solution to this problem.In the present work,we introduced ProstaNet,a deep learning framework that predicts stability changes resulting from single-and multiple-point mutations using geometric vector perceptrons-graph neural network for 3-dimensional feature processing.For training ProstaNet,we meticulously crafted ProstaDB,a comprehensive and pristine thermodynamics repository,including 3,784 single-point mutations and 1,642 multiple-point mutations.We also created thermodynamic looping for enlarging the limited data size of multiple-point mutation and applied an innovative clustering method to generate a standard testing set of multiple-point mutation.Besides,we identified residue scoring as the most important encoding method in protein properties prediction.With these innovations,ProstaNet accurately predicts thermostability changes for both single-point and multiple-point mutations without showing any bias.ProstaNet achieves an accuracy of 0.75,outperforming existing methods for single-point mutation prediction,including ThermoMPNN(0.63),PoPMuSiCsym(0.66),MUPRO(0.52),and FoldX(0.71).ProstaNet also achieves a 1.3-fold increase in accuracy compared to FoldX for multiple-point mutation predictions.Validated by experiment,4 out of 5 single-point mutation predictions(80%)and all multiple-point mutation predictions(100%)for HuJ3 mutants were accurate,demonstrating the potential benefits of ProstaNet for protein engineering and drug development. 展开更多
关键词 multiple point mutations geometric vector perceptrons single point mutations predicts stability changes experimental validation protein stability prediction graph neural network effects mutations protein stability
Unified light-thermal-diffusion coupling multi-mechanism kinetic model for gas-solid photocatalytic CO2 reduction with experimental and simulation validation 认领 引用
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作者 Shicheng Liu Du Wen +5 位作者 Jing Xiang Ng Junbo Yu Xiangyu Chen Lehang Chen Qulan Zhou Na Li 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2026年第6期854-867,I0020,共14页
Photocatalytic CO2 reduction in gas–solid systems is a complex process that requires the integrated consideration of illumination,photocatalytic performance,and gas diffusion on the catalyst surface.Oversimplifica... Photocatalytic CO2 reduction in gas–solid systems is a complex process that requires the integrated consideration of illumination,photocatalytic performance,and gas diffusion on the catalyst surface.Oversimplification of these factors in existing computational fluid dynamics models severely compromises their predictive capability under realistic reaction conditions.To address this limitation,this study develops a multi-mechanism kinetic model that integrates photoexcitation,Arrhenius thermal activation,Langmuir adsorption saturation,and Thiele diffusion resistance within a unified kinetic expression.Model parameters were constrained and validated using a combination of first-principles calculations and multiscale optical,spectroscopic,adsorption,and transport measurements in a tree-shaped uniform-flow reactor.Photocatalytic experiments of four distinct catalysts are then used to validate the multi-mechanism kinetic model,with R2 above 0.98.Under model-derived conditions,the operation of the tree-shaped reactor achieve an optimal conversion rate of 116.7μmol g-1h-1.The model reliably predicts the experimental rates across a wide range of operating conditions.It also accurately captures the optimal space velocity range and the promotional effect of increasing temperature.This work offers a generalizable framework for the theoretical understanding,modelling,and scale-up of photocatalytic CO2 conversion systems. 展开更多
关键词 Photocatalytic CO2conversion Multi-mechanism kinetic model Density functional theory Experiment validation
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Experimental validation of analytical solutions for estimating the minimum required strength of side-exposed backfill in underground mines 认领 引用
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作者 Islem Titey Li Li 《MetaResource》 2026年第1期62-71,共10页
In underground mining with backfill,it is essential to evaluate the minimum required strength of side-exposed backfill.An analytical solution proposed by Mitchell and coworkers in 1982 is largely used.Since 2012,Li an... In underground mining with backfill,it is essential to evaluate the minimum required strength of side-exposed backfill.An analytical solution proposed by Mitchell and coworkers in 1982 is largely used.Since 2012,Li and coworkers have published several improved solutions,accounting for several limitations in the Mitchell 1982 model.However,the improved solutions have not fully been validated by experimental results.Experimental work is necessary.As such,box instability tests were performed using an uncemented paste backfill under undrained conditions with a high aspect ratio stope.The unconfined compressive strength of the backfill was measured.Comparisons between experimental results and analytical results were made.A part of the experimental results was used to obtain the missing parameters through calibration.The other part of experimental results was then used to test the predictive capability of the calibrated analytical solutions.The results show that the improved analytical solutions provide a better agreement with the experimental results than the original Mitchell solution,at least for short-term stability of side-exposed backfill submitted to quasi-unconsolidated and undrained conditions.More experimental works are necessary to test the validity of the improved solutions under wider conditions. 展开更多
关键词 box instability tests experimental validation paste backfill side-exposed backfill Mitchell's solution
A Novel Dynamic Modeling and Analysis Method for Heat Transfer Systems Based on Frequency-Domain Transformation and Experimental Validation 认领 引用
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作者 GUO Chao HAO Junhong +3 位作者 SHAO Wei HONG Feng DU Xiaoze CHEN Qun 《Journal of Thermal Science》 SCIE EI CAS CSCD 2026年第4期1516-1538,共23页
Accurately analyzing and predicting the dynamic characteristics of heat transfer systems is significant for improving the operating efficiency and stability of industrial and energy systems.This paper develops a novel... Accurately analyzing and predicting the dynamic characteristics of heat transfer systems is significant for improving the operating efficiency and stability of industrial and energy systems.This paper develops a novel dynamic model for heat exchangers(HXs)by defining the new concept of virtual dynamic Number of Transfer Unit(NTU)using the Fourier frequency-domain transformation.On this basis,we derive an analytical linear relationship between the inlet and outlet temperatures of the HX to directly characterize its dynamic heat transfer behavior.Moreover,the dynamic heat current models and inlet-outlet temperature relationships of series,parallel,and multi-loop HX networks are derived and provided to describe the dynamic performance.We conduct dual validation of the dynamic model's accuracy through both simulations and experiments,achieving the maximum dynamic response errors for individual HX of less than 0.6%and 0.2%,respectively.By developing a parameter identification algorithm for the heat transfer system and integrating it with a complex heat exchange network experimental system,we further verify that the maximum error in dynamic performance analysis of the heat transfer system using this dynamic model does not exceed 0.4%,thereby demonstrating its accuracy and feasibility for analyzing the dynamic characteristics of heat transfer systems.The proposed model and method can serve as a powerful tool for the accurate analysis and prediction of the dynamic characteristics of heat transfer systems. 展开更多
关键词 frequency-domain heat current model heat exchanger Fourier transform dynamic performance experiment validation
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Dynamic Performances of a Double-Layer Vibration Isolation System:Nonlinear Modeling and Experimental Validation 认领 引用 被引量：1
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作者 Chao Zheng Jin Gao +1 位作者 Jianchao Liu Xin Xue 《International Journal of Mechanical System Dynamics》 EI CSCD 2025年第1期113-128,共16页
This work aims to identify ways to achieve dynamic performances of a novel double-layer vibration isolation system(DL-VIS)capable of achieving multi-directional isolation and extreme environmental adaptability.A forwa... This work aims to identify ways to achieve dynamic performances of a novel double-layer vibration isolation system(DL-VIS)capable of achieving multi-directional isolation and extreme environmental adaptability.A forward modeling approach applicable to complex systems has been developed and analyses of nonlinear dynamic characteristics under different working conditions are performed.First,by integrating with constitutive models in terms of individual elastic elements and the connective relationships within the structure,multidirectional constitutive models for isolation devices are established.Further,the decomposition of linear and nonlinear stiffness components in different directions is performed using the Taylor expansion method.Subsequently,the dynamic response under sinusoidal sweep frequency loading is obtained using the related stiffnesses in the dynamic model and adopting the extended harmonic balance method.The effects of stiffness,damping,and a nonlinear stiffness gradient on the DL-VIS response are thoroughly evaluated.Finally,the vibration isolation performance and nonlinear dynamics under different working conditions are examined,and the proposed dynamic model is experimentally validated.The results indicate that the response of DL-VIS varies significantly under different working conditions,particularly under overload conditions.The nonlinear characteristics lead to wide-band instability near the natural frequency and excellent vibration attenuation performance in multiple directions.The theoretical model agrees well with the experimental results in the nonresonant region and near the first resonant peak,which proves the prediction accuracy in the low-frequency range.These findings provide robust theoretical and technical support for the design and performance optimization of isolation systems. 展开更多
关键词 double-layer vibration isolation system dynamic model experimental validation harmonic balance method nonlinear
The Cancer Genome Atlas and experimental validation-based analysis of the SPRR2A gene's expression and clinical relevance in endometrial cancer 认领 引用
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作者 Yunhui Li Jie Zhang +3 位作者 Qingjian Ye Zhixian Liang Ranran Zhang Wenming Wu 《Gynecology and Obstetrics Clinical Medicine》 2025年第3期179-189,共11页
Objective This study aimed to identify SPRR2A as a hub gene in endometrial cancer(EC)and explore its potential as a diagnostic and prognostic biomarker.Methods Bioinformatics analysis was performed on highthroughput s... Objective This study aimed to identify SPRR2A as a hub gene in endometrial cancer(EC)and explore its potential as a diagnostic and prognostic biomarker.Methods Bioinformatics analysis was performed on highthroughput sequencing datasets of EC cases from The Cancer Genome Atlas.Reverse-transcription-quantitative PCR validated the differential expression of SPRR2A in EC cell lines and tissues.Results Compared with normal cells and adjacent tissues,EC cells and tissues showed significantly upregulated SPRR2A expression(p<0.05).High SPRR2A expression was associated with poor prognosis in EC patients(HR=1.52,95%CI 1.00 to 2.30,p=0.048).Furthermore,the expression levels of SPRR2A varied across histological grades,being significantly lower in G1 tumours than in G2 and G3 tumours.However,no significant differences in SPRR2A expression regarding age,clinical stage,tumour invasion or histological type were found.Conclusion SPRR2A is overexpressed in EC and serves as an independent predictor of poor prognosis.It may be a potential biomarker for EC diagnosis and prognosis.Further research is needed to explore its molecular mechanisms and clinical applications. 展开更多
关键词 cancer genome atlas endometrial cancer ec sprr prognostic biomarker experimental validation diagnostic biomarker endometrial cancer bioinformatics analysis
Accelerating the design of highly separable Fe-containing intermetallics in Al-Si alloys via DFT calculations and experimental validation 认领 引用
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作者 Xiaozu Zhang Dongtao Wang +10 位作者 Hiromi Nagaumi Rui Wang Zibin Wu Minghe Zhang Dongsheng Gao Hao Chen Pengfei Wang Pengfei Zhou Yunxuan Zhou Zhixiu Wang Tailin Li 《Materials Genome Engineering Advances》 CAS CSCD 2025年第2期45-62,共18页
The detrimental Fe element in Al-Si cast alloy can be effectively removed by Fecontaining intermetallics separation.However,the formation temperature of Fecontaining intermetallics can be further improved to increase ... The detrimental Fe element in Al-Si cast alloy can be effectively removed by Fecontaining intermetallics separation.However,the formation temperature of Fecontaining intermetallics can be further improved to increase the removal efficiency of Fe element.The effects of the Cr/Mn atomic ratio on the stability,theoretical melting point,elastic modulus,and thermal properties were calculated with the aim of improving the stability of theα-Al(FeMnCr)Si phase.An increased Cr/Mn atomic ratio effectively increased the stability,theoretical melting point,elastic modulus,isobaric heat capacity,and reduced the volumetric thermal expansion coefficient ofα-Al(FeMnCr)Si phase,which can be explained by the strengthened Al-Cr and Si-Cr chemical bonds.The experimental study results revealed that the formation temperature and Young's modulus of theα-Al(FeMnCr)Si phase increase from 673.0°C and 228.5 GPa to 732.0°C and 272.1 GPa with the Cr/Mn atomic ratio increasing from 0.11 to 0.8,which better validates the thermodynamic stability,theoretical melting point and elastic modulus calculation results.These results provide a new strategy for designing Fecontaining intermetallics with the desired properties,which contributes to guiding the development of high-performance recycled Al-Si alloys. 展开更多
关键词 DFT calculations experimental validation Fe-containing intermetallics stability thermal properties
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