期刊文献+
任意字段
题名或关键词
题名
关键词
摘要
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息
共找到3篇文章
< 1 >
每页显示 20 50 100
已选0条
引用分析
参考文献
引证文献
 统计分析
检索结果
已选文献
显示方式：
Integrated microoptical system for continuous fluorescence monitoring of microtissues 认领 引用
1
作者 Xu Tian Hanie Kavand +8 位作者 Martin Kohler Jessika Jessika Reison Gjaci Montse Visa Per-Olof Berggren Goran Stemme Wouter van der Wijngaart Anna Herland Niclas Roxhed 《Microsystems & Nanoengineering》 SCIE EI CSCD 2025年第6期379-392,共14页
Microphysiological systems(MPS)are advanced in vitro platforms engineered to replicate in vivo conditions forstudying human biology,disease mechanisms,and drug responses with greater physiological relevance.Fluorescen... Microphysiological systems(MPS)are advanced in vitro platforms engineered to replicate in vivo conditions forstudying human biology,disease mechanisms,and drug responses with greater physiological relevance.Fluorescencesensing is widely used as a functional readout in MPS due to its high sensitivity,selectivity,and stability.However,conventional fluorescence sensing systems often rely on bulky instrumentation with limited integration,whichrestricts continuous in situ monitoring,scalable high-throughput analysis,and spatially resolved investigation in multiorgan-on-a-chip models.To address these limitations,we present a highly miniaturized,fully integrated optical systemwith a 1 mm2 footprint,enabling continuous in situ fluorescence monitoring of three-dimensional microtissues inclose proximity.The system integrates microscale illumination and sensing units for fluorescence excitation andselective detection,an optical element for guided light propagation,and a microcage for mechanical confinement ofmicrotissues.To demonstrate its capabilities,we integrated the miniaturized optical system with an MPS-relevantplatform to monitor fluorescence signals in transgenic mouse pancreatic islets expressing genetically encoded calciumindicators.The integrated platform enables real-time,continuous monitoring of islet responses to potassium chloridestimulation and tracking of calcium oscillations for over two hours,providing valuable information about thefunctional status of the pancreatic islets.Our work enhances the analytical capabilities of MPS through the integrationof miniaturized on-chip quantitative assessment tools,enabling precise,in situ,and continuous monitoring ofbiological activities in close proximity. 展开更多
关键词 replicate vivo conditions situ monitoringscalable microtissues microphysiological systems vitro platforms fluorescence monitoring microphysiological systems mps integrated microoptical system
Recent advances in construction of small molecule-based fluorophoredrug conjugates 认领 引用 被引量：2
2
作者 Wenjie Lang Chaonan Yuan +4 位作者 Liquan Zhu Shubo Du Linghui Qian Jingyan Ge Shao Q Yao 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2020年第5期434-443,共10页
As a powerful tool to advance drug discovery,molecular imaging may provide new insights into the process of drug effect and therapy at cellular and molecular levels.When compared with other detection methods,fluoresce... As a powerful tool to advance drug discovery,molecular imaging may provide new insights into the process of drug effect and therapy at cellular and molecular levels.When compared with other detection methods,fluorescence-based strategies are highly attractive and can be used to illuminate pathways of drugs’transport,with multi-color capacity,high specificity and good sensitivity.The conjugates of fluorescent molecules and therapeutic agents create exciting avenues for real-time monitoring of drug delivery and distribution,both in vitro and in vivo.In this short review,we discuss recent developments of small molecule-based fluorophore-drug conjugates,including non-cleavable and cleavable ones,that are capable of visualizing drug delivery. 展开更多
关键词 Drug delivery Fluorescent monitoring Prodrug Cleavable linker
暂未订购 下载PDF
Fluorescent Detection of Trace Water in Methanol Based on an AI(III) Chemical Sensor 认领 引用
3
作者 Liang Hao Qi-ming Qiu +2 位作者 Wen-jie Wang Leilei Gu Hui Li 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2016年第11期1109-1113,共5页
A colorimetric and fluorescent sensor for trace water in methanol has been designed and characterized, which is a kind of aluminium-Schiff base coordination complex derived from diaminomaleonitrile. The fluorescence p... A colorimetric and fluorescent sensor for trace water in methanol has been designed and characterized, which is a kind of aluminium-Schiff base coordination complex derived from diaminomaleonitrile. The fluorescence properties of this complex have been studied based on excited state intramolecular proton transfer （ESIPT） and intramolecular charge transfer （ICT） mechanism. The fluorescent emission of AI-L complex can be quenched by 0.1% water and distinguished by naked eyes. The detection limitation is 0.01% recognized by fluorescence spectra. 展开更多
关键词 detection water content in methanol fluorescent monitoring ESIPT ICT
已选0条
引用分析
参考文献
引证文献
 统计分析
检索结果
已选文献
上一页 1 下一页 到第 页
在线咨询 使用帮助 返回顶部 意见反馈