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Immunoregulatory peptides from Ganoderma sinense:characterization,isolation,molecular docking and molecular mechanism 认领 引用
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作者 Qian Yang Nanwen Zhang +6 位作者 Huihong Zhang Xiaolin Huang Xixi Cai Ying Wu Jie Zhou Xiaole Chen Shaoyun Wang 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第3期1384-1398,共15页
Ganoderma sinense is a traditional and protein-rich edible fungus with outstanding immunoregulatory activity.However,the mechanism through which G.sinense protein hydrolysates and peptides exert their immunomodulatory... Ganoderma sinense is a traditional and protein-rich edible fungus with outstanding immunoregulatory activity.However,the mechanism through which G.sinense protein hydrolysates and peptides exert their immunomodulatory effects is unclear.The objective of this study was to prepare and isolate immunologically active peptides from G.sinense protein hydrolysates(GSP) and to investigate their impact on the activation of macrophages.G.sinense peptides with low molecular weights(< 1 kDa,87.76%) markedly promoted RAW264.7 cell proliferation;increased their phagocytic capacity,nitric oxide(NO),tumor necrosis factor-α(TNF-α),interleukin-10(IL-10),and IL-6 secretion and reactive oxygen species(ROS) production;and upregulated Tlr2 mRNA expression.In addition,GSP promoted nuclear factor kappa-B(NF-κB) activation and translocation through the upregulation of p65 and p-p65 protein expression.Virtual molecular screening technology revealed that compared with other peptides,the SFAGNIPVNR,YGDAFIR and TVSYLPAPQR peptides derived from GSP showed stronger binding affinities.Interaction site map analysis indicated that the SFAGNIPVNR and YGDAFIR peptides formed stable hydrogen bonds with toll-like receptor 2(TLR2).Together,these results suggested that G.sinense peptides can serve as important ingredients in nutraceuticals or functional foods. 展开更多
关键词 Immunoregulatory peptide Ganoderma sinense Nuclear factor kappa-B Toll-like receptor 2
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Novel triterpenoids from Ganoderma resinaceum attenuate UV-induced photoaging via modulating Nrf2 and MAPK signaling pathways 认领 引用
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作者 Yi Luo Xiao-Cui Liu +2 位作者 Yu-Jie Li Ming-Hua Qiu Xing-Rong Peng 《Natural Products and Bioprospecting》 CSCD 2026年第1期93-108,共16页
As a dual-purpose medicinal and edible mushroom,Ganoderma species have garnered significant interest in both the food,cosmetics and pharmaceutical industries.To further substantiate its traditional and functional uses... As a dual-purpose medicinal and edible mushroom,Ganoderma species have garnered significant interest in both the food,cosmetics and pharmaceutical industries.To further substantiate its traditional and functional uses,we conducted a systematic phytochemical study of Ganoderma resinaceum fruiting bodies,isolating 43 lanostane-type triterpenoids.Among these,16 were identified as new compounds(1-11,15,31,35,37,and 42).Compound 1 represents the first reported C29 lanostane triterpenoid featuring a 21,24-cyclo five membered carbon ring fraction.The spectroscopic(1D/2D NMR,ESIMS)and X-ray crystallographic analyses confirmed their structures.Among these,compounds 2-4,13,17,35,36,and 42 exhibited potent antioxidant activity by suppressing UV-induced ROS in skin keratinocytes.The most active compound,42,reduced ROS and malondialdehyde(MDA)levels,enhanced antioxidant defenses(superoxide dismutase,SOD;hydroxyproline),and suppressed matrix metalloproteinases(MMPs)through activating Nrf2 pathway and suppressing MAPK signaling.These results position G.resinaceum triterpenoids,particularly compound 42,as multifunctional natural antioxidants with applications in functional foods for oxidative stress management or skin-protective formulations. 展开更多
关键词 Ganoderma resinaceum Lanostane-type triterpenoids Nrf2 MAPK signaling pathway Skin photoaging
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Network pharmacology and AI:illuminating the path to precision herbal medicine in Ganoderma spp. 认领 引用
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作者 Aman Sharma Sonali Khanal +6 位作者 Divyesh Suvedi Neelesh Yadav Rachna Verma Dinesh Kumar Ashwani Tapwal Lukas Peter Vinod Kumar 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2026年第5期559-573,共15页
Ganoderma species are promising sources of bioactive natural products with substantial pharmacological potential and have long been valued in traditional Chinese medicine(TCM)for their diverse therapeutic properties.H... Ganoderma species are promising sources of bioactive natural products with substantial pharmacological potential and have long been valued in traditional Chinese medicine(TCM)for their diverse therapeutic properties.However,their complex multi-component,multi-target nature presents significant challenges in elucidating pharmacodynamic mechanisms and optimizing clinical applications.Recent advances in network pharmacology(NP)and artificial intelligence(AI)offer innovative strategies to address these challenges.NP integrates compound-target-pathway-disease networks,while AI enhances predictive modeling,target prioritization,and the analysis of large-scale pharmacological data.Together,these approaches facilitate mechanistic interpretation,rational formulation,and personalized use of Ganodermaderived medicines.This review highlights recent progress in applying NP and AI to identify key bioactive constituents and therapeutic pathways of Ganoderma spp.,while also addressing limitations related to data quality,standardization,and clinical translation.By emphasizing the synergy between traditional TCM theory and modern computational technologies,this integrative approach advances natural medicine research and holds promise for strengthening the scientific foundation and global acceptance of Ganoderma-based therapeutics. 展开更多
关键词 Traditional Chinese Medicine Ganoderma spp. Artificial intelligence Fungi Herbal medicine Bioactive compounds Therapeutic pathways
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Dual-action therapeutics of Ganoderma spores:integrating bioactivity and delivery for acute lung injury treatment 认领 引用
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作者 Zi-Wei Guo Yang Zhou +5 位作者 Wen-Na Sun Yi-Tao Zhao Mei Tian Yi-Hao Ye Shi-Wei Duan Yue-Liang Zheng 《Traditional Medicine Research》 2026年第9期55-66,共12页
Acute lung injury(ALI)is a critical condition characterized by the destruction of the alveolar-capillary barrier,infiltration of inflammatory cells,and an imbalance in oxidative stress,with a mortality rate reaching 3... Acute lung injury(ALI)is a critical condition characterized by the destruction of the alveolar-capillary barrier,infiltration of inflammatory cells,and an imbalance in oxidative stress,with a mortality rate reaching 30%-40%.Acute respiratory distress syndrome(ARDS)represents a severe form of ALI.The pathogenesis of ALI is complex,involving a cytokine storm,excessive production of reactive oxygen species(ROS),and endothelial cell damage.Current treatments,such as mechanical ventilation and glucocorticoids,offer limited efficacy and significant side effects,highlighting the urgent need for the development of novel,targeted treatment strategies.Recent studies have demonstrated that bioactive components of Ganoderma lucidum spores(GLS),particularly Ganoderma lucidum polysaccharides and triterpenes,possess significant pharmacological properties such as antioxidant,anti-inflammatory,and immunomodulatory activities.In recent years,natural drug delivery systems have gained considerable attention due to their biocompatibility and functional diversity.Among these,GLS have emerged as promising carriers for the treatment of ALI,owing to their unique physicochemical properties and biological activity.The Ganoderma lucidum spore delivery system provides a dual-treatment paradigm,functioning simultaneously as a natural carrier and an active ingredient,which enhances its efficacy and safety for ALI therapy.Compared to synthetic materials,it boasts superior biodegradability,lower immunogenicity,and reduced preparation costs,making it well-suited for industrial-scale production.Furthermore,its clinical translational potential has been demonstrated in tumor adjuvant therapy,where it has shown promise in enhancing immune function and improving the quality of life for chemotherapy patients.This article reviews the potential applications and mechanisms of GLS as drug delivery carriers in the treatment of ALI. 展开更多
关键词 Ganoderma lucidum spores drug delivery system acute lung injury inflammatory response therapeutic mechanism
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Lanostane triterpenoids and nor-abietane aromatic diterpenoid from Ganoderma applanatum and their neuroprotective activity 认领 引用
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作者 Han Wu Mengyue Dong +7 位作者 Yifan Guo Zhengbin Zong Mengke Zhang Xin Chen An'an Yang Mingming Cao Jinming Gao Xia Yin 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第6期2920-2934,共15页
The Ganoderma fungus has been revered for centuries in traditional Chinese medicine and foods with high nutritional value for its purported health benefits.The extracts of Ganoderma applanatum(Pers.)Pat.showed promisi... The Ganoderma fungus has been revered for centuries in traditional Chinese medicine and foods with high nutritional value for its purported health benefits.The extracts of Ganoderma applanatum(Pers.)Pat.showed promising protective activity against neurological damage caused by scopolamine in zebrafish.Eleven highly oxygenated lanostane triterpenoids with one or moreα,β-unsaturated conjugated moiety,including three previously undescribed compounds appterpenactones A-C(1-3),and a nor-abietane diterpenoid,ganorphenol(4),together with related congeners were obtained from the fruiting bodies of G.applanatum.The structures and absolute configurations of the previously undescribed compounds were elucidated by analysis of nuclear magnetic resonance(NMR)spectra,quantum chemical calculations of NMR and electronic circular dichroism spectra,and X-ray crystallographic data.Compound 1 shares an unusual 6/6/5/6/5 ring system scaffold,while compound 4 represents a rearranged aromatic diterpenoid with rare ortho-dimethyl groups.All compounds were evaluated for their neuroprotective activity in glutamate-induced mouse hippocampal neuronal cell line(HT-22 cells).Ganorphenol(4)and applanoic acid C(6)demonstrated significant neuroprotective activity in inhibiting glutamate-induced HT22 cell death.Biochemical assays suggest that applanoic acid C may exert protective effects by activating the Nrf2/HO-1 pathway.Moreover,the further mechanistic study revealed that ganorphenol(4)can exert neuroprotective effects through the PI3K-AKT-mTOR pathway.Collectively,comprehensive experiments and molecular docking studies demonstrated that compounds 4 and 6 are potential neuroprotective agents.These findings provide valuable insights into the actions of trace bioactive components from edible materials and contribute to the broader understanding of neuroprotective compounds. 展开更多
关键词 Ganoderma applanatum Medicinal-edible mushroom Rearranged abeo-lanostane skeleton Aromatic diterpenoid Neuroprotective activity Glutamate-induced HT-22 cell
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Discovery and mechanism of anti-hypertensive effect of a novel tripeptide(SYP)from medicinal fungus Ganoderma lingzhi 认领 引用 被引量：2
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作者 Qiang Wu Feijun Luo +4 位作者 Jia Huang Ping Huang Yongnan Liu Xiaoling Wang Gaoqiang Liu 《Food Science and Human Wellness》 SCIE CAS CSCD 2025年第2期509-524,共16页
Ganoderma lingzhi is a new species of the prize medicinal mushroom Ganoderma(Agaricomycetes).Using angiotensin I-converting enzyme(ACE)as a target,a tripeptide Ser-Tyr-Pro(SYP)was discovered with preponderant ACE inhi... Ganoderma lingzhi is a new species of the prize medicinal mushroom Ganoderma(Agaricomycetes).Using angiotensin I-converting enzyme(ACE)as a target,a tripeptide Ser-Tyr-Pro(SYP)was discovered with preponderant ACE inhibitory activity with an 50%inhibiting concentration(IC50)value of 62.50μg/mL attribute to the formed salt bridge and hydrogen bonds between SYP and ACE.SYP even maintained superior bioactivity after intestinal digestion,and exerted no cytotoxicity,but presented incomplete bioavailability in blood of spontaneous hypertensive rats(SHRs).Furthermore,it performed antihypertensive effect in vivo by inhibiting the influx of Ca2+through activating endothelial NO synthase(e NOS)/NO/guanosine 3',5'-cyclic monophosphate(c GMP)pathway,accompanied by attenuating angiotensin II(Ang II)/NADPH oxidase(NOX)eactive oxygen species(ROS)pathway.This work not only discoverers a novel pharmacological ingredient from medicinal mushroom G.lingzhi for hypertension therapy,but also provides an insight into molecular mechanism of the ACE inhibitory peptide(ACEIP)on lowering blood pressure. 展开更多
关键词 Antihypertensive peptide Ganoderma lingzhi Gene microarray Molecular mechanism
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Structure-function insights of natural Ganoderma polysaccharides:advances in biosynthesis and functional food applications 认领 引用 被引量：2
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作者 Zhou-Wei Wu Xue-Fang Zhao +5 位作者 Chen-Xi Quan Xiao-Cui Liu Xin-Yu Tao Yu-jie Li Xing-Rong Peng Ming-Hua Qiu 《Natural Products and Bioprospecting》 CSCD 2025年第2期143-175,共33页
Ganoderma polysaccharides(GPs),derived from various species of the Ganoderma genus,exhibit diverse bioactivities,including immune modulation,anti-tumor effects,and gut microbiota regulation.These properties position G... Ganoderma polysaccharides(GPs),derived from various species of the Ganoderma genus,exhibit diverse bioactivities,including immune modulation,anti-tumor effects,and gut microbiota regulation.These properties position GPs as dual-purpose agents for medicinal and functional food development.This review comprehensively explores the structural complexity of six key GPs and their specific mechanisms of action,such as TLR signaling in immune modulation,apoptosis pathways in anti-tumor activity,and their prebiotic effects on gut microbiota.Additionally,the structure-activity relationships(SARs)of GPs are highlighted to elucidate their biological efficacy.Advances in green extraction techniques,including ultrasonic-assisted and enzymatic methods,are discussed for their roles in enhancing yield and aligning with sustainable production principles.Furthermore,the review addresses biotechnological innovations in polysaccharide biosynthesis,improving production efficiency and making large-scale production feasible.These insights,combined with ongoing research into their bioactivity,provide a solid foundation for developing health-promoting functional food products that incorporate GPs.Furthermore,future research directions are suggested to optimize biosynthesis pathways and fully harness the health benefits of these polysaccharides. 展开更多
关键词 Ganoderma polysaccharides extraction techniques structural characteristics Bioactivity biosynthetic pathways Functional food applications
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The versatile plant probiotic bacterium Bacillus velezensis SF305 reduces red root rot disease severity in the rubber tree by degrading the mycelia of Ganoderma pseudoferreum 认领 引用
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作者 Min Tu Zhongfeng Zhu +8 位作者 Xinyang Zhao Haibin Cai Yikun Zhang Yichao Yan Ke Yin Zhimin Sha Yi Zhou Gongyou Chen Lifang Zou 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2025年第8期3112-3126,共15页
Natural rubber is an indispensable material of strategic importance that has critical applications in industry and the military.However,the development of the natural rubber industry is impeded by the red root rot dis... Natural rubber is an indispensable material of strategic importance that has critical applications in industry and the military.However,the development of the natural rubber industry is impeded by the red root rot disease of rubber trees caused by Ganoderma pseudoferreum,which is one of the most devastating diseases in the rubber tree growing regions in China.To combat this disease,we screened the antifungal activity of 223 candidate bacterial strains against G.pseudoferreum,and found that Bacillus velezensis strain SF305 exhibited significant antifungal activity against G.pseudoferreum.Bacillus velezensis SF305 had a nearly 70%efficacy against the red root rot disease of rubber trees with the therapeutic treatment(Tre),while it exhibited over 90%protection effectiveness with the preventive treatment(Pre).The underlying biocontrol mechanism revealed that B.velezensis SF305 could reduce the disease severity of red root rot by degrading the mycelia of G.pseudoferreum.An antiSMASH analysis revealed that B.velezensis SF305 contains 15 gene clusters related to secondary metabolite synthesis,13 of which are conserved in species of B.velezensis,but surprisingly,B.velezensis SF305 possesses 2 unique secondary metabolite gene clusters.One is predicted to synthesize locillomycin,and the other is a novel nonribosomal peptides synthetase(NRPS)gene cluster.Genomic analysis showed that B.velezensis SF305 harbors genes involved in motility,chemotaxis,biofilm formation,stress resistance,volatile organic compounds(VOCs)and synthesis of the auxin indole-3-acetic acid(IAA),suggesting its plant growth-promoting rhizobacteria(PGPR)properties.Bacillus velezensis SF305 can promote plant growth and efficiently antagonize some important phytopathogenic fungi and bacteria.This study indicates that B.velezensis SF305 is a versatile plant probiotic bacterium.To the best of our knowledge,this is the first time a B.velezensis strain has been reported as a promising biocontrol agent against the red root rot disease of rubber trees. 展开更多
关键词 Bacillus velezensis Ganoderma pseudoferreum red root rot disease rubber tree biocontrol comparative genomics
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Neuroprotective and antidiabetic lanostane-type triterpenoids from the fruiting bodies of Ganoderma theaecolum 认领 引用
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作者 Jiaocen Guo Li Yang +6 位作者 Luting Dai Qingyun Ma Jiaoyang Yan Qingyi Xie Yougen Wu Haofu Dai Youxing Zhao 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2025年第2期245-256,共12页
Eight previously undescribed lanostane triterpenoids,including five nortriterpenoids with 26carbons,ganothenoids A-E(1-5),and three lanostanoids,ganothenoids F-H(6-8),along with 24 known ones(9-32),were isolated from ... Eight previously undescribed lanostane triterpenoids,including five nortriterpenoids with 26carbons,ganothenoids A-E(1-5),and three lanostanoids,ganothenoids F-H(6-8),along with 24 known ones(9-32),were isolated from the fruiting bodies of Ganodrma theaecolum.The structures of the novel compounds were elucidated using comprehensive spectroscopic methods,including electronic circular dichroism(ECD)and nuclear magnetic resonance(NMR)calculations.Compounds 1-32 were assessed for their neuroprotective effects against H2O2-induced damage in human neuroblastoma SH-SY5Y cells,as well as their inhibitory activities against protein tyrosine phosphatase 1B(PTP1B)andα-glucosidase.Compound 4demonstrated the most potent neuroprotective activity against H2O2-induced oxidative stress by suppressing G_0/G_1 phase cell cycle arrest,reducing reactive oxygen species(ROS)levels,and inhibiting cell apoptosis through modulation of B-cell lymphoma 2 protein(Bcl-2)and Bcl-2 associated X-protein(Bax)protein expression.Compounds 26,12,and 28 exhibited PTP1B inhibitory activities with IC50values ranging from 13.92 to 56.94μmol·L~(-1),while compound12 alone displayed significant inhibitory effects onα-glucosidase with an IC50value of 43.56μmol·L~(-1).Additionally,enzyme kinetic analyses and molecular docking simulations were conducted for compounds 26 and 12 with PTP1B andα-glucosidase,respectively. 展开更多
关键词 Ganoderma theaecolum Lanostane nortriterpenoids Neuroprotective effects PTP1B α-Glucosidase
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Antitumor effects of different Ganoderma lucidum spore powder in cell-and zebrafish-based bioassays 认领 引用 被引量：27
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作者 Yue-jiao Shi Hua-xian Zheng +4 位作者 Zhu-ping Hong Han-bo Wang Ying Wang Ming-yan Li Zhen-hao Li 《Journal of Integrative Medicine》 SCIE CAS CSCD 2021年第2期177-184,共8页
Objective:Ganoderma lucidum spore(GLS)is gaining recognition as a medicinal part of G.lucidum and has been reported to possess various pharmacological properties,such as antitumor activity.In this work,wall-broken GLS... Objective:Ganoderma lucidum spore(GLS)is gaining recognition as a medicinal part of G.lucidum and has been reported to possess various pharmacological properties,such as antitumor activity.In this work,wall-broken GLS powder(BGLSP)and wall-removed GLS powder(RGLSP),two kinds of GLS powder with different manufacturing techniques,were compared in terms of contents of active constituents and in vivo and in vitro antitumor effects.Methods:The ultraviolet and visible spectrophotometry method was used to determine the contents of polysaccharides and total triterpenoids in BGLSP and RGLSP.Seventeen individual triterpenoids were further quantified using ultra-high-performance liquid chromatography and quantitative analysis of multicomponents by single marker.The antitumor effects of BGLSP and RGLSP were evaluated using in vitro cell viability assay against human gastric carcinoma SGC-7901,lung carcinoma A549 and lymphoma Ramos and further validated by in vivo zebrafish xenograft models with transplanted SGC-7901,A549 and Ramos,Results:The results showed that the contents of polysaccharides,total triterpenoids and individual triterpenoids of RGLSP were significantly higher than those of BGLSP.Although both BGLSP and RGLSP inhibited the three tumor cell lines in vitro in a dose-dependent manner,the inhibitory effects of RGLSP were much better than those of BGLSP.In the in vivo zebra fish assay,RGLSP exhibited more potent inhibitory activities against tumors transpla nted into the zebra fish compared with BGLSP,and the inhibition rates of RGLSP reached approximately 78%,31%and 83%on SGC-7901,A549 and Ramos,respectively.Conclusion:The results indicated that the antitumor effects of GLS were positively correlated with the contents of the polysaccha rides and triterpenoids and demonstrated that the wall-removing manufacturing technique could significantly improve the levels of active constituents,and thereby enhance the antitumor activity. 展开更多
关键词 Ganoderma lucidum Tumor Cancer cell Zebrafish Wall-broken Ganoderma lucidum spore powder Wall-removed Ganoderma lucidum spore powder
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Light repair effect of polysaccharides component from white Ganoderma lucidum and Laminaria japonica fermentation broth attenuates epidermal barrier dysfunction via TRPV4-Keap-1/Nrf2 pathway 认领 引用
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作者 Xinrui Jiang Qianru Sun +6 位作者 Yunxia Chen Ning Su Jiaxuan Fang Zixin Song Meng Li Changtao Wang Dongdong Wang 《Bioresources and Bioprocessing》 SCIE EI CSCD 2025年第1期1820-1833,共14页
Epidermal photoinflammation has emerged as an atypical pathological response that poses a growing global threat to human health and well-being.In this study,a polysaccharide component(named LJGp)was isolated from Lami... Epidermal photoinflammation has emerged as an atypical pathological response that poses a growing global threat to human health and well-being.In this study,a polysaccharide component(named LJGp)was isolated from Laminaria japonica and white Ganoderma lucidum fermentation broth,and its reparative effects on UVB-induced epidermal damage were investigated.LJGp was found to restore the migration ability of HaCaT cells,increase antioxidant enzyme activities,and clear excessive intracellular ROS.At 1500μg/mL,ROS levels were reduced to about 50%of those in the UVB group,while IL-6 expression decreased to a level comparable with the control group.At the same time,LJGp increased barrier functional proteins,inhibited desmosome degradation,and maintained the stability of the epidermal barrier.Mechanistic results further showed that LJGp regulated the TRPV4-Keap-1/Nrf2 pathway,where UVB-induced TRPV4 activation suppressed Nrf2 activity and promoted AP-1-mediated inflammation.By reducing TRPV4 overexpression and restoring Nrf2 function,LJGp alleviated barrier dysfunction and improved epidermal repair.These results provide supporting data and a scientific basis for the development and utilization of LJGp as an epidermal photoinflammatory relief agent. 展开更多
关键词 Laminaria japonica Fermented polysaccharides Epidermal photoinflammation Skin barrier TRPV4-Keap-1/Nrf2 signaling pathway Ganoderma lucidum
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Indigenous Trichoderma isolates from Bukit Kijang,North Sumatra,Indonesia,are biocontrol agents against Ganoderma boninense in infected oil palm seedlings 认领 引用
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作者 Lisnawita I.Safni +5 位作者 H.Hanum M.Effendy S.F.Sitepu A.R.Tantawi W.S.Saragih H.Ali Elenshasy 《Ecological Frontiers》 CSCD 2025年第1期175-184,共10页
Basal stem rot,caused by Ganoderma boninense is a serious disease in oil palm plantations in North Sumatra,Indonesia.However,the use of fungicides to control this pathogen can cause instability in terrestrial ecosyste... Basal stem rot,caused by Ganoderma boninense is a serious disease in oil palm plantations in North Sumatra,Indonesia.However,the use of fungicides to control this pathogen can cause instability in terrestrial ecosystems and decrease the number of beneficial microorganisms.Therefore,identifying other effective and environmentally friendly control methods,such as Trichoderma,is essential.Trichoderma was previously isolated from the leaf,rachis,stem,and root tissues of oil palms but not from the rhizosphere soil.Therefore,this study aimed to assess the potency of indigenous Trichoderma isolates from the rhizosphere soil of oil palm seedling plantations in Bukit Kijang,North Sumatra,Indonesia,as biocontrol agents to reduce G.boninense infection.Four Trichoderma isolates were isolated from healthy oil palm rhizospheres in Bukit Kijang and screened in vitro.Based on molecular identification,the Trichoderma isolates were identified as T.asperellum1,T.virens1,T.asperellum2,and T.virens2.All Trichoderma species inhibited the development of Ganoderma and stimulated the vegetative growth of oil palm seedlings.Therefore,T.asperellum and T.virens can be used as biocontrol agents to control G.boninense and stimulate the vegetative growth of oil palm seedlings.To our knowledge,this is the first report of indigenous Trichoderma isolates from Bukit Kijang that can be used as biocontrol agents to control G.boninense. 展开更多
关键词 Trichoderma Basal stem rot Biocontrol Elaeis guineensis Ganoderma boninense
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Molecular identification and quality evaluation of commercial Ganoderma 认领 引用
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作者 Leijiao Liu Lihui Wei +7 位作者 Jing Xu Hui Xiong Shasha Zhou Shuangcheng Ma Wei Sun Lixia Tian Zhenhao Li Zhichao Xu 《Medicinal Plant Biology》 2025年第1期402-413,共12页
Ganoderma has long been renowned in oriental countries as a prominent medicinal and edible supplement,with the products holding a substantial market demand.However,there remains a lack of systematic and comprehensive ... Ganoderma has long been renowned in oriental countries as a prominent medicinal and edible supplement,with the products holding a substantial market demand.However,there remains a lack of systematic and comprehensive studies on the quality evaluation of commercial Ganoderma.In this study,we analyzed 84 batches of Ganoderma,including the fruiting bodies and spores,sourced from various markets.DNA barcoding using the ITS2 marker was employed and demonstrated excellent discriminatory capacity,allowing for the precise identification of 16 adulterants among the 84 Ganoderma.According to the standard detection methods for total polysaccharides and triterpenes outlined in the Chinese Pharmacopoeia,remarkable variations in the tested Ganoderma samples were observed;the total polysaccharide contents ranged from 0.22%to 3.31%,while the total triterpenes levels varied from 0.21%to 10.56%.Furthermore,LC-MS/MS quantification based on targeted ganoderic acids for Ganoderma revealed triterpene contents ranging from 0.01%to 0.98%,highlighting the necessity for regulating the quality of Ganoderma in the market.A comprehensive evaluation system for commercial Ganoderma is proposed,integrating molecular identification and mass spectrometry quantification. 展开更多
关键词 quality evaluation its marker adulterants molecular identification DNA barcoding commercial Ganoderma fruiting bodies
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Study on the Synergistic Antioxidant and Anti-Wrinkle Tightening Effect of Vitamin C and Black Ganoderma Extract 认领 引用
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作者 Xu Wenfeng Niu Qiang +2 位作者 Xu Shanlang Li Shiwei Li Yaxin 《China Detergent & Cosmetics》 CAS 2025年第1期41-46,共6页
The antioxidant and anti-wrinkle firming effects of a combination of vitamin C(Vc)and black Ganoderma lucidum extract was evaluted.Through the DPPH radical scavenging model and elastase inhibition model,this research ... The antioxidant and anti-wrinkle firming effects of a combination of vitamin C(Vc)and black Ganoderma lucidum extract was evaluted.Through the DPPH radical scavenging model and elastase inhibition model,this research investigates the impact of these substances individually and in combination on antioxidant capabilities and anti-wrinkle firming effects.The results demonstrate that the combination of Vc and black Ganoderma lucidum extract exhibits significant antioxidant abilities at various concentrations,and is more effective than when each is used separately,indicating a synergistic interaction between them.Additionally,the combination also shows significant inhibition of elastase,suggesting potential applications in delaying the aging process of the skin.Furthermore,highperformance liquid chromatography(HPLC)was used to determine if reactions occur among the components of the mixture.The findings reveal that the concentration of Vc in the mixture is very close to the theoretical concentration and relatively stable,suggesting that the components function independently.A quantitative analysis using the Bliss independence model further confirms the synergistic effects of Vc and black Ganoderma lucidum extract at specific ratios,providing a scientific basis for the development of efficacious cosmetic products. 展开更多
关键词 Vitamin c black ganoderma lucidum extract antioxidant anti-wrinkle firming synergistic effects
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Meroterpenoids from Ganoderma Species:A Review of Last Five Years 认领 引用 被引量：9
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作者 Xingrong Peng Minghua Qiu 《Natural Products and Bioprospecting》 2018年第3期137-149,共13页
Meroterpenoids are hybrid natural products that partially originate from the terpenoid pathway.Ganoderma meroterpenoids(GMs)are a type of meroterpenoids containing a 1,2,4-trisubstituted phenyl and a polyunsaturated t... Meroterpenoids are hybrid natural products that partially originate from the terpenoid pathway.Ganoderma meroterpenoids(GMs)are a type of meroterpenoids containing a 1,2,4-trisubstituted phenyl and a polyunsaturated terpenoid part.Over last 5 years,great efforts have been made to conduct phytochemistry research on the genus Ganoderma,which have led to the isolation and identification of a number of GMs.These newly reported GMs showed diverse structures and a wide range of biological activities.This review gives an overview of new GMs from genus Ganoderma and their biological activities and biosynthetic pathway,focusing on the period from 2013 until 2018. 展开更多
关键词 Ganoderma Ganoderma meroterpenoids New structures Biological activities
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New alkaloids from the fruiting bodies of Ganoderma sinense 认领 引用 被引量：4
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作者 Jie-Qing LIU Cui-Fang WANG +1 位作者 Xing-Rong PENG Ming-Hua QIU 《Natural Products and Bioprospecting》 2011年第2期93-96,共4页
Four new alkaloids,sinensines B-E(1-4),together with one known alkaloid,sinensine(5),were isolated from the fruiting bodies of Ganoderma sinense.Their structures were elucidated on the basis of 1D and 2D NMR spectra a... Four new alkaloids,sinensines B-E(1-4),together with one known alkaloid,sinensine(5),were isolated from the fruiting bodies of Ganoderma sinense.Their structures were elucidated on the basis of 1D and 2D NMR spectra analysis.The structure of sinensine E was confirmed by X-ray crystallographic analysis of its acetyl product(4a). 展开更多
关键词 Ganoderma sinense Ganodermataceae alkaloids sinensines
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山东灵芝Ganoderma shandongense中的肽类化合物及其α-葡萄糖苷酶抑制活性 认领 引用 被引量：1
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作者 顾文迪 马世元 +2 位作者 王雨曦 魏玉莲 袁海生 《菌物学报》 CAS CSCD 北大核心 2025年第9期127-137,共11页
本研究开展了山东灵芝Ganoderma shandongense大米固体发酵物中的肽类化合物及其α-葡萄糖苷酶抑制活性科学试验研究。采用硅胶柱色谱、反相ODS柱色谱、HP20柱色谱和高效液相色谱(HPLC)等方法分离纯化,利用质谱(MS)、核磁共振(NMR)等方... 本研究开展了山东灵芝Ganoderma shandongense大米固体发酵物中的肽类化合物及其α-葡萄糖苷酶抑制活性科学试验研究。采用硅胶柱色谱、反相ODS柱色谱、HP20柱色谱和高效液相色谱(HPLC)等方法分离纯化,利用质谱(MS)、核磁共振(NMR)等方法对化合物进行结构鉴定,得到10个肽类化合物,分别为:(3S,6R)-3-(cyclopropylmethyl)-6-(1H-indol-3-ylmethyl)-2,5-piperazinedione(1)、cyclo-(Leu-Val)(2)、cyclo-(L-Pro-L-Ile)(3)、cyclo-(L-Phe-L-Pro)(4)、cyclo-(Asn-phe)(5)、cyclo-(L-Phe-L-Leu)(6)、cyclo-(Tyr-Leu)(7)、cyclo-(D-Phe-L-Ile)(8)、fenestins A(9)、cyclo-(LeuPro-Ile-Pro)(10)。通过p NPG法对化合物1-10的α-葡萄糖苷酶抑制活性进行测定,其中化合物8抑制α-葡萄糖苷酶的IC50值为(1.13±0.10)μmol/L,接近于阳性药阿卡波糖[IC50值为(0.98±0.03)μmol/L]的功效,该研究结果为山东灵芝的药用功能提供了理论数据支撑。 展开更多
关键词 山东灵芝 化学成分 肽类 结构鉴定 α-葡萄糖苷酶抑制活性
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Studies on Active Polysaccharides from Ganoderma lucidum vith Immune Activity 认领 引用 被引量：5
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作者 何云庆 李荣芷 +3 位作者 陈琪 林志彬 夏冬 马莉 《Journal of Chinese Pharmaceutical Sciences》 CAS 1992年第1期79-81,共3页
从云头状灵芝[Ganoderma Lucidum(Leyss.ex Fr.)Karst.]中分离得到三种灵芝多糖BN3A，BN3B及BN3C，它们均表现明显免疫调节作用。从灵芝多糖BN3B及BN3C中各分离得到四个多糖均一体，对其中主要成分BN3C1，BN3C3，BN3B1及BN3B3进行了物... 从云头状灵芝[Ganoderma Lucidum(Leyss.ex Fr.)Karst.]中分离得到三种灵芝多糖BN3A，BN3B及BN3C，它们均表现明显免疫调节作用。从灵芝多糖BN3B及BN3C中各分离得到四个多糖均一体，对其中主要成分BN3C1，BN3C3，BN3B1及BN3B3进行了物理及化学研究，它们的平均分子量依次为1.6×10^4，2.5×10^4，3.5×10^4及4.0×10^4。经完全酸水解、红外光谱测定、过碘酸氧化、甲酸生成、Smith降解等证明，BN3B1及BN3C1均为β－（1→6)(1→3）甙键相连的葡聚糖。BN3B3为阿拉伯半乳聚糖。BN3C3为由葡萄糖和阿拉伯糖组成的肽多糖。它们均为β－（1→6）（1→3）甙键相连。 展开更多
关键词 Ganoderma lucidum Ganoderma polysaccharides Immune activity
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Fermentation Production of Ganoderma lucidum by Bacillus subtilis Ameliorated Ceftriaxone-induced Intestinal Dysbiosis and Improved Intestinal Mucosal Barrier Function in Mice 认领 引用 被引量：5
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作者 LIU He FAN Qing-Jie +2 位作者 LIU Yin-Hui LI Ming YUAN Jie-Li 《Digital Chinese Medicine》 CAS 2020年第3期199-212,共14页
Objective This study aimed to develop a type of Ganoderma lucidum(G.lucidum)-probiotic fermentation broth that can effectively improve the intestinal mucosal barrier function of mice with ceftriaxone-induced intestina... Objective This study aimed to develop a type of Ganoderma lucidum(G.lucidum)-probiotic fermentation broth that can effectively improve the intestinal mucosal barrier function of mice with ceftriaxone-induced intestinal dysbiosis.Methods By means of absorbance of optical density(OD)value and phenol-concentrated sulfuric acid measurement of polysaccharide content,the probiotic species can grow on the medium of G.lucidum were screened out,and the concentration of the medium of G.lucidum was determined,and the fermentation broth was prepared for subsequent experiments.Thirty-two SPF grade male BALB/c mice were randomly divided into four groups(eight mice in each group),namely control group(CON),intestinal mucosal barrier damage model group(CS),fermentation broth intervention group(FT)and G.lucidum medium intervention group(GL),respectively.The intestinal dysregulation model was induced by intra-gastric administration of 0.2 mL ceftriaxone sodium(twice a day for seven consecutive days).From day 8,the FT group and GL group were gavage with 0.2 mL fermentation broth and G.lucidum medium,respectively.On day 15,all mice were sacrificed.To draw the weight curve and measure the cecal index;pathological examination of colon tissues with HE staining;serum levels of LPS,IL-10,TNF and IL-6 were detected by ELISA.Flow cytometry was used to analyze the changes of CD3+T cells,CD4+T cells,CD8+T cells and macrophages in spleen.16S rRNA sequencing was performed to detect the intestinal microbiota structure of mice.Results Bacillus subtilis can decompose and utilize G.lucidum fruiting body medium,and the suitable concentration of G.lucidum fruiting body medium is 33.2 mg/mL.The effect of Bacillus subtilis-G.lucidum fermentation broth on the damage of intestinal mucosal barrier caused by ceftriaxone sodium was reduced,the body weight of mice recovered and colon swelling improved,colon histopathological injury was alleviated,inflammatory cell infiltration was alleviated,serum IL-10 increased significantly,LPS、TNF-αand IL-6 decreased significantly compared with model group,and the proportion of T cells and intestinal dysbiosis was improved.Conclusions The experimental results suggest that Bacillus subtilis-G.lucidum fermentation broth can effectively improve the intestinal barrier function damage,immune dysfunction and intestinal dysbiosis caused by antibiotic overdose,and has a certain regulatory effect on intestinal mucosal barrier function. 展开更多
关键词 Ganoderma lucidum Bacillus subtilis Traditional Chinese medicine fermentation Ganoderma lucidum acid Intestinal mucosal barrier function Intestinal dysbiosis Regulate Tcell responses
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Studies on the Triterpenoid Constituents of the Spores from Ganoderma lucidum Karst 认领 引用 被引量：4
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作者 陈若芸 于德泉 《Journal of Chinese Pharmaceutical Sciences》 CAS 1993年第2期91-96,共6页
Five compounds were isolated from the ether-soluble fraction of the spores of Gano- derma lucidum.On the basis of their chemical properties and spectral data(MS,UV,IR,~1H and 13CNMR),they were identified as 3,7,11,... Five compounds were isolated from the ether-soluble fraction of the spores of Gano- derma lucidum.On the basis of their chemical properties and spectral data(MS,UV,IR,~1H and 13CNMR),they were identified as 3,7,11,12,15,23-hexaoxo-5α-lanosta-8-en-26-oic acid(Ⅰ),gano- deric acid B(Ⅱ),C(Ⅲ),D(Ⅳ)and ganodermanontriol(Ⅴ).Compound Ⅰ is a new natural product, named ganosporeric acid A.Compounds Ⅱ,Ⅲ,Ⅳ and Ⅴ are known compounds and were obtained for the first time from the spores of Ganoderma lucidum.Pharmacological experiments showed that ganosporeric acid A has an activity for lowering the levels GPT in mice with liver injury by CCl_4 and GaNI and exhibits heptoprotective effects. 展开更多
关键词 Spores of Ganoderma lucidum Ganosporeric acid A Ganoderic acid B,C,E Ganodermanontriol
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