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GPP(composition of Ganoderma lucidum polysaccharides and Polyporus umbellatus polysaccharides) protects against DSS-induced murine colitis by enhancing immune function and regulating intestinal flora 认领 引用 被引量：6
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作者 Liyuan Li Yannan Guo +6 位作者 Qing Huang Xiaojin Shi Qingqing Liu Fang Wang Qingfei Liu Kang Yu Zhao Wang 《Food Science and Human Wellness》 SCIE CAS CSCD 2022年第4期795-805,共11页
Previous study have demonstrated that a compound composed of water-soluable Ganoderma lucidum polysaccharides(GLP)and Polyporus umbellatus polysaccharides(PUP)in a ratio of 3:1 named GPP enhances innate immune functio... Previous study have demonstrated that a compound composed of water-soluable Ganoderma lucidum polysaccharides(GLP)and Polyporus umbellatus polysaccharides(PUP)in a ratio of 3:1 named GPP enhances innate immune function in mice through enhancing the function of macrophage cells and activity of natural killer(NK)cells.Here in our research,we further investigated the effect of GPP on the diversity and composition of intestinal flora,and explored its effect on colitis model mice.The immunoregulatory verification experiments of GPP were conducted in both normal and DSS-induced mice model.Our research showed that GPP increased the diversity of intestinal microorganisms in mice with the extension of administration time.Daily GPP intake attenuated DSS-induced colon injury,protected the splenic lymphocyte proliferation ability,enhanced the serum hemolysin synthesis,and increased peripheral phagocytes and NK cell activity in model mice.Comparisons of the predominant gene pathways of the bacterial microbiota showed that DNA repair and recombination,base mismatch repair pathways was stronger in GPP-treatment group than in control group,indicating the possible molecular mechanisms of immune function regulation.Our study showed that GPP regulated immune function in both health and colitis model,and had a positive effect on maintaining intestinal flora homeostasis. 展开更多
关键词 Ganoderma lucidum polysaccharides Polyporus umbellatus polysaccharides Immune function Intestinal flora Colitis
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Related gene expressions in anti-keratinocyte aging induced by Ganoderma lucidum polysaccharides 认领 引用 被引量：9
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作者 Xie Shaoqiong Liao Wanqing +1 位作者 Yao Zhirong Wang Zhidong 《Journal of Medical Colleges of PLA(China)》 2008年第3期167-175,共9页
Objective:To examine the level of expression of anti skin aging gene of Ganoderma lucidum polysacchayides and clarify its mechanism with anti aging of this ancient Chinese medicine.Methods:HacaT cell of keratinocytes ... Objective:To examine the level of expression of anti skin aging gene of Ganoderma lucidum polysacchayides and clarify its mechanism with anti aging of this ancient Chinese medicine.Methods:HacaT cell of keratinocytes lines were cultured and treated with the polysaccharides.The total RNA was extracted with Trizol reagent and cDNA was synthesized by reverse thanscription.The obtained cDNAs were then fluorescently labeled with cy3 and cy5 respectively and hybridized with gene expressing pedigree cDNA chip.The images were scanned and analyzed with special software.The scan data were analyzed with software and checked by real time PCR.Results:Among total 18 346 human genes,the expression of 103 ones was up-regulated and 378 ones down-regulated.It was demonstrated evidently that Ganoderma lucidum polysaccharides affected the expression of genes of anti skin aging.Two ways are anastomotic.Conclusion:it is concluded by analysis of function of these up-regulation and down-regulation genes that Ganoderma lucidum polysaccharides may play an important role in boosting cell growth and against skin aging.It shows that the results of gene array reliable by real time PCR. 展开更多
关键词 Ganoderma lucidum polysaccharides Skin aging Gene chip Keratinocyte
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Effects of Ganoderma lucidum polysaccharides peptide on tumor metastasis in mice with sleep fragmentation 认领 引用
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作者 LI Di-tian ZHU Yin-an +4 位作者 LI Jia-yi ZHANG Yi-meng TAN Zhe-lun LI Si-yan PAN Yan 《中国药理学与毒理学杂志》 CAS 北大核心 2019年第9期688-688,共1页
In recent years,studies have shown that there is a correlation between sleep disorders and cancer,but at the present stage,the research on sleep disorders and tumor related animal models is relatively insufficient.Our... In recent years,studies have shown that there is a correlation between sleep disorders and cancer,but at the present stage,the research on sleep disorders and tumor related animal models is relatively insufficient.Our research will focus on mice bearing B16F10-luc-G5 melanoma tumor with sleep fragmentation,detecting promoting effect of sleep fragmentation(SF)on the metastasis of melanoma.At the same time,we used Ganoderma lucidum poly⁃saccharides peptide(GL-pp,80 mg·kg-1),a component of traditional Chinese medicine Ganoderma lucidum,which has long enjoyed a good reputation at home and abroad,to observe its anti-tumor metastasis effects on B16F10-luc-G5 mice with SF.Then we used whole proteomics to analyze the difference proteins expressed in lung tissue and compared between groups,includes mice bearing B16F10-luc-G5,mice bearing B16F10-luc-G5 with SF and GL-pp administered mice bearing B16F10-luc-G5 with SF.With the analysis using bioinformatics,we found several key proteins,their genes name are Adcy9,ptk2,Yap1 and Lpin2,Per1 and Tim.And several important clusters,they are,immune system,platelet aggres⁃sion,energy metabolism,cell cytoskeleton,cell adhesion and circadian rhythms.Moreover,we detected the TLR4 signal pathway and macrophage differentiation to reconfirm the results of proteomics and trying to elucidate the mechanism of SF on tumor growth and metastasis and the effects of GL-pp. 展开更多
关键词 Ganoderma lucidum polysaccharide peptide fragmented sleep melanoma proteomics tumor immunity
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Ganoderma lucidum polysaccharides:A comprehensive overview of pharmacological effects and future perspectives 认领 引用 被引量：1
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作者 Hui Fang Shangpeng Yang Teng Yang 《Food Bioscience》 SCIE 2025年第2期110-124,共15页
Ganoderma lucidum polysaccharides(GLPs),derived from the medicinal mushroom Ganoderma lucidum,are recognized for their diverse pharmacological properties.This systematic review offers a detailed analysis of how the st... Ganoderma lucidum polysaccharides(GLPs),derived from the medicinal mushroom Ganoderma lucidum,are recognized for their diverse pharmacological properties.This systematic review offers a detailed analysis of how the structure of GLPs influences their biological functions.It focuses on how factors such as the types of sugars they are made of,their size,branching patterns,and any chemical modifications affect their activities.We synthesized data from cellular,animal,and available clinical studies to highlight the impact of these structural features on GLPs’immunomodulatory,antioxidative,anti-inflammatory,and antitumor activities.The review also addresses the current challenges in GLPs research,including the variability in extraction methods,the lack of standardized quality control,and the need for further studies to clarify structure-activity relationships.Although GLPs show significant therapeutic potential,there is a need for more rigorous clinical trials,deeper mechanistic insights,and the development of standardized production methods to optimize their therapeutic applications.Future research should also explore novel drug formulations,alternative delivery systems,and the sustainable production of GLPs using agro-industrial waste,as these advancements could significantly enhance their clinical use.Despite substantial progress,challenges remain in fully realizing the therapeutic potential of GLPs,and overcoming these hurdles will be crucial for their future clinical application and integration into health-promoting products. 展开更多
关键词 Ganoderma lucidum Ganoderma lucidum polysaccharides Structure-function relationship Pharmacological effects Systematic review
Recent advances in Ganoderma lucidum polysaccharides:Structures/bioactivities,biosynthesis and regulation 认领 引用 被引量：12
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作者 Zi-Ying Zhang Feng-Jie Cui +2 位作者 Lei Sun Xin-Yi Zan Wen-Jing Sun 《Food Bioscience》 SCIE 2023年第6期187-195,共9页
Ganoderma lucidum is a well-known functional food-grade and medicinal mushroom with 2000-year history for promoting health and longevity in Asian countries.G.lucidum polysaccharides are the most investigated biologica... Ganoderma lucidum is a well-known functional food-grade and medicinal mushroom with 2000-year history for promoting health and longevity in Asian countries.G.lucidum polysaccharides are the most investigated biological components due to their attracting nutritional and medicinal values.The increasing efforts have also attempted to understand the biosynthesis pathways of G.lucidum polysaccharides and the roles of involved key genes based on the recent rapid advances and increasing availability in G.lucidum genome.On this basis,the present study presented the updated progresses on structural characteristics,bioactivities/potential mechanisms,and complex biosynthesis process/associated key genes of G.lucidum polysaccharides(GLPs)in the past 5 years.The recent process optimization and genetic engineering to maximally produce GLPs were also summarized.The future trends and challenges to answer the structure-activity relationship,biosynthesis and molecular regulation of GLPs are also proposed. 展开更多
关键词 Ganoderma lucidum polysaccharides(GLPs) Structures Bioactivities Biosynthesis Regulation strategies
Extraction of Astragalus Polysaccharides and Ganoderma lucidum Mycelia Polysaccharides and Their in Vitro Antioxidative Effects 认领 引用 被引量：2
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作者 Hongping LIN Yonglin HUANG 《Asian Agricultural Research》 2023年第1期36-40,46,共5页
[Objectives]To explore the extraction and in vitro antioxidant effects of astragalus polysaccharides(APS)and Ganoderma lucidum mycelia polysaccharides(GLMPS).[Methods]By studying the polysaccharides of the herbal medi... [Objectives]To explore the extraction and in vitro antioxidant effects of astragalus polysaccharides(APS)and Ganoderma lucidum mycelia polysaccharides(GLMPS).[Methods]By studying the polysaccharides of the herbal medicinal material Astragalus membranaceus and the fungal medicinal material Ganoderma lucidum mycelia,two polysaccharides were mixed according to different proportions and concentrations by using the principle of traditional Chinese medicine compound combination.The effect of polysaccharides on the scavenging ability of hydroxyl radical system was determined by salicylic acid method.[Results]When the compound ratios of GLMPS and APS were 1∶1,1∶4,1∶5,4∶1,and 5∶1,the scavenging effect of compound polysaccharides was better than that of single-component polysaccharides,and with the increase of concentration,the scavenging effect increased.When the ratio of GLMPS and APS was 5∶1,the hydroxyl radical scavenging rate of the compound polysaccharide reached 59.77%,which was 18.72%higher than that of single GLMPS and 28.58%higher than that of single APS.The scavenging effect of compound polysaccharide is closely related to the compound ratio and concentration.[Conclusions]APS and GLMPS can obtain better hydroxyl radical scavenging ability than single-component polysaccharides through compounding in appropriate proportions.In addition,within a suitable concentration range,as the concentration increases,the scavenging ability also increases. 展开更多
关键词 Astragalus polysaccharides(APS) Ganoderma lucidum mycelia polysaccharides(GLMPS) Compound polysaccharide Hydroxyl radical scavenging rate
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Renal protective effect of Ganoderma lucidum 认领 引用 被引量：1
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作者 Dan-dan ZHONG Zheng-wei XIE +6 位作者 Bo-yue HUANG Shuai ZHU Guo-qian WANG Hong ZHOU Shu-qian LIN Zhi-bin LIN Bao-xue YANG 《中国药理学与毒理学杂志》 CAS CSCD 北大核心 2018年第4期254-255,共2页
OBJECTIVE Non-alcoholic fatty liver disease(NAFLD) encompasses a series of patho.logic changes ranging from steatosis to steatohepatitis,which may progress to cirrhosis and hepatocel.lular carcinoma.The purpose of thi... OBJECTIVE Non-alcoholic fatty liver disease(NAFLD) encompasses a series of patho.logic changes ranging from steatosis to steatohepatitis,which may progress to cirrhosis and hepatocel.lular carcinoma.The purpose of this study was to determine whether Ganoderma lucidum polysaccha.ride peptide(GLPP) has therapeutic effect on NAFLD.METHODS ob/ob mouse model and ApoC3 transgenic mouse model were used for exploring the effect of GLPP on NAFLD.Key metabolic path.ways and enzymes were identified by metabolomics combining with KEGG and PIUmet analyses and key enzymes were detected by Western blotting.Hepatosteatosis models of HepG2 cells and primary hepatocytes were used to further confirm the therapeutic effect of GLPP on NAFLD.RESULTS GLPP administrated for a month alleviated hepatosteatosis,dyslipidemia,liver dysfunction and liver insulin resistance.Pathways of glycerophospholipid metabolism,fatty acid metabolism and primary bile acid biosynthesis were involved in the therapeutic effect of GLPP on NAFLD.Detection of key enzymes revealed that GLPP reversed low expression of CYP7 A1,CYP8 B1,FXR,SHP and high expression of FGFR4 in ob/ob mice and ApoC3 mice.Besides,GLPP inhibited fatty acid synthesis by reducing the expression of SREBP1 c,FAS and ACC via a FXR-SHP dependent mechanism.Additionally,GLPP reduced the accumulation of lipid droplets and the content of TG in HepG2 cells and primary hepato.cytes induced by oleic acid and palmitic acid.CONCLUSION GLPP significantly improves NAFLD via regulating bile acid synthesis dependent on FXR-SHP/FGF pathway,which finally inhibits fatty acid synthesis,indicating that GLPP might be developed as a therapeutic drug for NAFLD. 展开更多
关键词 Ganoderma lucidum polysaccharide peptide NAFLD insulin resistance hepatosteatosis nuclear receptors
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Ganoderma lucidum polysaccharide peptide alleviates hepatoteatosis via modulating bile acid metabolism dependent on FXR-SHP/FGF 认领 引用 被引量：1
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作者 ZHONG Dan-dan YANG Bao-xue 《中国药理学与毒理学杂志》 CAS 北大核心 2019年第9期703-704,共2页
OBJECTIVE Ganoderma lucidum polysaccharide peptide(GLPP)is a group of extract from Ganoderma lucidum with a molecular mass of approximately 5×10^5,which ratio of polysaccharide to peptide is approximately 95%/5%.... OBJECTIVE Ganoderma lucidum polysaccharide peptide(GLPP)is a group of extract from Ganoderma lucidum with a molecular mass of approximately 5×10^5,which ratio of polysaccharide to peptide is approximately 95%/5%.The purpose of this study was to determine whether GLPP has therapeutic effect on Non-alcoholic fatty liver disease(NAFLD).METHODS Ob/ob mouse model and ApoC3 transgenic mouse model were used for exploring the effect of GLPP on NAFLD.Key metabolic pathways and enzymes were identified by metabolomics combining with KEGG and PIUmet analyses and key enzymes were detected by Western blotting.Hepatosteatosis models of HepG2 cells and primary hepatocytes were used to further confirm the therapeutic effect of GLPP on NAFLD.RESULTS GLPP administrated for a month alleviated hepatosteatosis,dyslipidemia,liver dysfunction and liver insulin resistance.Pathways of glycerophos⁃pholipid metabolism,fatty acid metabolism and primary bile acid biosynthesis were involved in the therapeutic effect of GLPP on NAFLD.Detection of key enzymes revealed that GLPP reversed low expression of CYP7A1,CYP8B1,FXR,SHP and high expression of FGFR4 in ob/ob mice and ApoC3 mice.Besides,GLPP inhibited fatty acid synthesis by reducing the expression of SREBP1c,FAS and ACC via a FXR-SHP dependent mechanism.Additionally,GLPP reduced the accumulation of lipid droplets and the content of TG in HepG2 cells and primary hepatocytes induced by oleic acid and palmitic acid.CONCLUSION GLPP significantly improves NAFLD via regulating bile acid synthesis dependent on FXR-SHP/FGF pathway,which finally inhibits fatty acid synthesis,indicating that GLPP might be developed as a ther⁃apeutic drug for NAFLD. 展开更多
关键词 Ganoderma lucidum polysaccharide peptide NAFLD insulin resistance hepatosteatosis metabolo⁃mics bile acid synthesis nuclear receptors fatty acid synthesis
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Effect of Ganoderma lucidum Polysaccharide on Antioxidative Ability of Rats with Myocardial Injury Induced by Doxorubicin 认领 引用 被引量：1
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作者 Fan Xu Xiao Li +3 位作者 Qingshan Li Xiao Xu Wenxin Li Xiaolei Yu 《Journal of Biosciences and Medicines》 2022年第4期14-19,共6页
Objective: The objective is to investigate the effect of Ganoderma lucidum polysaccharide (GLPS) on the oxidative stress induced by doxorubicin (DOX) in cardiomyocytes. Methods: SD rats were divided into control group... Objective: The objective is to investigate the effect of Ganoderma lucidum polysaccharide (GLPS) on the oxidative stress induced by doxorubicin (DOX) in cardiomyocytes. Methods: SD rats were divided into control group, DOX group, GLPS low dose and high dose + DOX group. SOD and MDA levels in myocardial tissue were detected in each group. The expression of related proteins in each group was detected by Western blot. Results: GLPS can increase the SOD level and decrease MDA caused by DOX (p Conclusion: Ganoderma polysaccharide can improve the oxidative stress injury of myocardial tissue induced by doxorubicin and play a protective role in myocardial tissue. 展开更多
关键词 Doxorubicin Ganoderma lucidum Polysaccharide Myocardial Tissue Antioxidant Capacity
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The Impact on Extraction Effect of Polysaccharide from Ganoderma lucidum by Different Pretreatment 认领 引用 被引量：2
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作者 Jinyi LIANG Jinghao ZHOU +2 位作者 Jianping ZHOU Yifeng TAN Keyong XU 《Medicinal Plant》 2018年第3期14-16,20,共3页
[Objectives] The research aimed to study the impact on extraction effect of polysaccharide from Ganoderma lucidum( lingzhi) by different pretreatment methods. [Methods] The impacts on extraction of G. lucidum polysacc... [Objectives] The research aimed to study the impact on extraction effect of polysaccharide from Ganoderma lucidum( lingzhi) by different pretreatment methods. [Methods] The impacts on extraction of G. lucidum polysaccharide by soaking,microwave and air flow fine pulverization were contrasted,and the extraction effect of G. lucidum polysaccharide by combining the optimal pretreatment manner with hot water extraction,alcohol extraction,alkali extraction,ultrasonic binding enzyme extraction,and microwave extraction was compared. Finally,the property of G. lucidum polysaccharide obtained after air flow fine pulverization pretreatment was detected and analyzed by high performance liquid chromatography. [Results] The optimal pretreatment method was air flow fine pulverization. Compared with traditional method-direct extraction( coarse grinding combining hot water extraction),crude yield changed little,while polysaccharide content and yield were improved by 114% and 104%. The best combination manner was air flow fine pulverization pretreatment combining with alkali extraction. Compared with traditional method,crude yield,polysaccharide content and yield were improved by 76%,78% and 215% respectively. The property of G. lucidum polysaccharide obtained after air flow fine pulverization pretreatment was detected and analyzed by high performance liquid chromatography. It was found that the treatment method had little impact on the property of G. lucidum polysaccharide. [Conclusions]Air flow fine pulverization pretreatment could greatly improve extraction effect of G. lucidum polysaccharide,which mainly improved the content and yield of G. lucidum polysaccharide,and extraction was more complete,with less impact on the property of the extracted polysaccharide. It was speculated that air flow fine pulverization pretreatment mainly destroyed mechanical support wall membrane structure of G. lucidum fine powder,making that intracellular functional substances completely dissolved out of the cell,and the content would be studied in follow-up experiment. 展开更多
关键词 Pretreatment Air flow fine pulverization Ganoderma lucidum polysaccharide Extraction effect Polysaccharide property
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Ganoderma lucidum polysaccharide inhibits LPS-induced inflammatory injury to mammary epithelial cells 认领 引用 被引量：4
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作者 Yi Fan Wei Wang +5 位作者 Xuefang Wang Liqin Yu Yue Wei Lei Wei Xiaoyang Xie Xiao Li 《Journal of Future Foods》 2023年第1期49-54,共6页
This study sought to investigate whether Ganoderma lucidum polysaccharide(GLP)has a protective effect on lipopolysaccharide(LPS)-induced inflammatory injury to mammary epithelial HC-11 cells and to characterize the me... This study sought to investigate whether Ganoderma lucidum polysaccharide(GLP)has a protective effect on lipopolysaccharide(LPS)-induced inflammatory injury to mammary epithelial HC-11 cells and to characterize the mechanism involved.Cell viability was assessed using the cell counting kit 8(CCK-8)method,tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and IL-1βlevels were measured by enzyme linked immunosorbent assay(ELISA),and IκBa,p65 NF-κB and STAT3 mRNA were determined using quantitative reverse transcription PCR(qRT-PCR),p65 and STAT3 protein expression were determined using Western blotting,respectively.GLP was shown to inhibit LPS-induced TNF-α,IL-6,and IL-1βproduction(P<0.01 or P<0.05),GLP was also shown to increase IκBαmRNA expression(P<0.01),decrease p65 and STAT3 mRNA expression(P<0.01 or P<0.05),and decrease p-p65,p65,p-STAT3,and STAT3 protein expression in breast epithelial cells(P<0.01 or P<0.05).The findings suggest that GLP inhibits nuclear factor kappa-B(NF-κB)and signal transducers and activators of transcription(STAT)signaling by preventing IκBαdegradation and p65 and STAT3 phosphorylation.This results in lower LPS-induced TNF-α,IL-6,and IL-1βproduction and prevents inflammatory cell injury. 展开更多
关键词 Ganoderma lucidum polysaccharide Lipopolysaccharide Mouse mammary epithelial cells Inflammatory injury
Effects of GLP on Intestinal Mucosal Injury and the Change of TNF-α Content in Hemorrhagic Shock Rabbits 认领 引用
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作者 杨红梅 CHEN Jie +1 位作者 LI Yi-pei WANG Li 《河南医学高等专科学校学报》 2015年第6期691-694,共4页
Objective To observe the intestinal mucosal injury and the change of TNF-αcontent in rabbits with hemorrhagic shockeperfusion(HS-R)and the effects of ganoderma Lcidum polysaccharide(GLP)on them.Methods 30rabbits were... Objective To observe the intestinal mucosal injury and the change of TNF-αcontent in rabbits with hemorrhagic shockeperfusion(HS-R)and the effects of ganoderma Lcidum polysaccharide(GLP)on them.Methods 30rabbits were made into hemorrhagic shock,then reperfused with different liquids.These rabbits were divided by random number table into three groups:sham operation group(Sham group),reperfusion with normal saline group(NS group),reperfusion with 1%GLP group(LS group).Bacterial translocation of blood and TNF-αcontent in serum were respectively observed at the time before shock,40 min after shock,40 min and 90 min after.TNF-αcontent in intestinal mucosa and the degree of intestinal mucosal injury were examined at 90 min post-resuscitation.Results 1 With the extension of reperfusion time,the positive rate of blood bacteria increased gradually in NS group,which was significantly higher than that of Sham group and LS group(P<0.05),meanwhile the degree of intestinal mucosal injury in NS group was more severe than that of Sham group and LS group too(P<0.05).2TNF-αcontent in serum of NS group and LS group were increased obviously compared with that before shock and in Sham group(P<0.05).TNF-αcontent in serum was further increased after reperfusion with NS,which was distinctly higher than that in LS group.TNF-αcontent in intestinal mucosa of NS group was significantly higher than that in LS group and Sham group too(P<0.05).Conclusion GLP can protect intestinal mucosa against HS-R injury,and its effects may relate with the change of TNF-αin hemorrhagic shock rabbits. 展开更多
关键词 hemorrhagic shock reperfusion injury ganoderma Lucidum polysaccharide intestinal mucosa TNF-α
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