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Humanization for neurological disease modeling:A roadmap to increase the potential of Drosophila model systems 认领 引用 被引量：1
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作者 Vladimir L.Katanaev 《Animal Models and Experimental Medicine》 CAS CSCD 2023年第3期230-236,共7页
Neuroscience and neurology research is dominated by experimentation with rodents.Around 75%of neurology disease-associated genes have orthologs in Drosophila mel-anogaster,the fruit fly amenable to complex neurologica... Neuroscience and neurology research is dominated by experimentation with rodents.Around 75%of neurology disease-associated genes have orthologs in Drosophila mel-anogaster,the fruit fly amenable to complex neurological and behavioral investiga-tions.However,non-vertebrate models including Drosophila have so far been unable to significantly replace mice and rats in this field of studies.One reason for this situ-ation is the predominance of gene overexpression(and gene loss-of-function)meth-odologies used when establishing a Drosophila model of a given neurological disease,a strategy that does not recapitulate accurately enough the genetic disease condi-tions.I argue here the need for a systematic humanization approach,whereby the Drosophila orthologs of human disease genes are replaced with the human sequences.This approach will identify the list of diseases and the underlying genes that can be adequately modeled in the fruit fly.I discuss the neurological disease genes to which this systematic humanization approach should be applied and provide an example of such an application,and consider its importance for subsequent disease modeling and drug discovery in Drosophila.I argue that this paradigm will not only advance our un-derstanding of the molecular etiology of a number of neurological disorders,but will also gradually enable researchers to reduce experimentation using rodent models of multiple neurological diseases and eventually replace these models. 展开更多
关键词 disease modeling Drosophila humanization neurological diseases
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Transformations of Working Time as a Factor of Labour Dehumanization 认领 引用 被引量：1
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作者 Renata Tomaszewska-Lipiec 《China-USA Business Review》 2015年第8期417-425,共9页
Shortening working time and making it more flexible, which have been observed in Europe since mid-20th century, are perceived as the main features and conditions for labour humanization as well as the sign of social p... Shortening working time and making it more flexible, which have been observed in Europe since mid-20th century, are perceived as the main features and conditions for labour humanization as well as the sign of social progress. The aim of the article has been showing negative consequences of this phenomenon, especially for maintaining balance between work and private life. It was based on hypothesis that the tendency to shorten the working time and to make it more flexible cannot be seen only as a factor of humanization, as the achievements of the social policy in Europe have been accompanied by many negative aspects, having a negative influence over both employees and employers. One of those observed occurrences were progressive disturbances in balancing work and private life. The considerations have been based on critical literature analysis method, the analysis of formal legal documents and statistics reports and sources. The transformations of working time and their influence over free time shortage and thus the imbalance between work and private life have been analysed. The theoretical-problem analyses allowed to reach the conclusion that the transformations of working time, related to negative changes in its organization, can be perceived as a factor of dehumanization of one＇s work. 展开更多
关键词 world of labour working time free time flexibility humanization work-life balance
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Challenges of the dialog between humanization of health and medicine for the assistance to woman health in the Brazilian scenario 认领 引用
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作者 Denise Ribeiro Barreto Mello Ligia Costa Leite 《Health》 2013年第9期1386-1393,共8页
The present article aims to present, by a bibliographic review, the current challenges of the dialog among fundamental issues referring to humanization as for current public policy in Brazilian scenario. The first one... The present article aims to present, by a bibliographic review, the current challenges of the dialog among fundamental issues referring to humanization as for current public policy in Brazilian scenario. The first one concerns with national health humanization policies and ultimately the humanization of the assistance to the woman’s health, especially at delivery and child birth. Using the hermeneutic dialectic as methodology, it’s understood that having these three facets, dialog consists not only of a great challenge but also of a condition on being put into practice, and expected issues become an effective reality. 展开更多
关键词 Medical Education Humanization of Assistance Medical Cares Women Health
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Industrial Dehumanization——Viewed from the husband and wife relationship in "Odour of Chrysanthemums" 认领 引用
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作者 何苗 《科教文汇》 2007年第1期164-165,共2页
Lawrence is regarded as one of most accomplished short story writers in twentieth century,with "Odour of Chrysanthemums" one of his early works.Through the death of a miner,the text shows how humanity was ru... Lawrence is regarded as one of most accomplished short story writers in twentieth century,with "Odour of Chrysanthemums" one of his early works.Through the death of a miner,the text shows how humanity was ruined by industrial civilization.This essay is intended to unveil the destructive force by analyzing the relationship between the husband and wife. 展开更多
关键词 human relationship industrialization isolation dehumanization
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Successful Digital Transformation and HRM Humanization 认领 引用
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作者 Yakhontova Yelena 《Economics World》 2019年第2期67-74,共8页
This paper investigates a core role of Human Resource Management(HRM)humanization for successful digital transformation in digital economy.The term“humanization”is applied to an iterative method of human relation de... This paper investigates a core role of Human Resource Management(HRM)humanization for successful digital transformation in digital economy.The term“humanization”is applied to an iterative method of human relation development for human resources satisfaction and high results of organizational performance.The author summarized the peculiarities of digitalization in Russian companies in the context of the Russian labor market trends.The paper focuses on factors that determine human potential utilization and development in modern condition.The author grounded linkage between HRM humanization and digital transformation projects effect by three examples of Russian companies.The results let us conclude importance of HRM humanization and define core problems and directions in Russian context. 展开更多
关键词 humanization Human Resource Management(HRM) digital economy knowledge economy digital transformation soft management labor market
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Humanization in Educational Environments;Aspects Necessary for Living in School Today 认领 引用
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作者 JoséManuel Salum Tomé 《Sociology Study》 2022年第6期239-242,共4页
While it is true,quality has always been measured through statistics and percentages,often forgetting the training of the whole person.Now,when we talk about issues such as humanism and education supported by technolo... While it is true,quality has always been measured through statistics and percentages,often forgetting the training of the whole person.Now,when we talk about issues such as humanism and education supported by technology,we can fall into extremes:it is common to label technology as the provider of all the evils of today’s civilization;or the opposite assumption;to argue that incorporating technologies into education would be the panacea for all the problems it faces and finally,to assume that the subject of the humanities is more typical of actions and attitudes of the past than as a current need,giving vitality to any educational process.However,and fortunately for the educational community,today there are global efforts to make the educational task a human action that minimizes inequities and the abysmal differences that exist in countries like ours.Fernando Reimers says:“Equal educational opportunities must be the priority objective of educational policies,the aim of education must be to contribute to creating just societies”.This requires improving the learning environments of the poor,but not only along the paths that have been started over the last decade.This aspect pointed out by Reimers is precisely the central aspect that all educational action must contemplate;the educational policies that are implemented in our country must guarantee,above all,the construction of a just and egalitarian society,strengthening the cultural wealth that we have,with respect to the diversity of people,their past,their present and especially their future. 展开更多
关键词 person integrity humanization education technologies
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Discussion of the theories of the humanization in the education and management of the college students 认领 引用
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作者 Xue Lei 《International English Education Research》 2015年第1期14-16,共3页
In the education and management, people are the objects of the management, and also are the subjects. So in the education of the college students, how can we effectively carry on the management？ In view of this probl... In the education and management, people are the objects of the management, and also are the subjects. So in the education of the college students, how can we effectively carry on the management？ In view of this problem, this paper explains the profound theories with the description of the simple language from three aspects of the basic connotation of the humanization in the educational and management of the college students, the lack of the humanization in the education and management of the college students and its significance, and the thinking of the methods of the humanization in the education and management of the college students, to solve the concept of the humanization in the management, in order to provide the theoretical reference of the humanized management for the educators. 展开更多
关键词 College education education and management humanization thinking
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Research on the Humanization of the Animal Protagonist in The Call of the Wild 认领 引用
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作者 PAN Juan 《International English Education Research》 2016年第12期106-109,共4页
Jack London was one of the outstanding American writers in the late nineteenth and early twentieth century. The Call of the Wild which was based on the Klondike Gold Rush, was the most famous and popular one in China.... Jack London was one of the outstanding American writers in the late nineteenth and early twentieth century. The Call of the Wild which was based on the Klondike Gold Rush, was the most famous and popular one in China. These years, lots of scholars have discussed it from various aspects, such as the contents, the themes, the writing styles and its characters. In this short novel, the protagonist Buck is humanized by the author. He is endowed with lots of human qualities, such as loyalty, brave, self-esteem, intelligence and so on. What are the reasons of humanization of the dog protagonist.？ Finding out the reasons could help us understand this novel better and it may offer some references for the research on Jack London＇ s animal novels. 展开更多
关键词 Jack London The Call of the Wild： animal humanization
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Application of Humanization Concept in Residential Architectural Design 认领 引用
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作者 XIAOWenhan 《外文科技期刊数据库（文摘版）工程技术》 2022年第7期048-051,共4页
With the development of the times, all aspects of life are changing, and concepts are also changing. People have higher and higher requirements for living environment, space and layout, especially in todays low-carbon... With the development of the times, all aspects of life are changing, and concepts are also changing. People have higher and higher requirements for living environment, space and layout, especially in todays low-carbon society. People prefer a healthy, happy and comfortable living environment. With the continuous improvement of peoples living needs, the design concept of "people-oriented" in architectural design also appears. It adopts humanized design to create a warm and pleasant atmosphere. Therefore, in the current residential building design, it is necessary to meet the needs of residents. While living needs, we should also consider the impact of the living environment on all aspects of human beings, so as to create a livable living environment for human beings. 展开更多
关键词 residential building design humanized concept application strategy
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Human cerebral organoids:Complex,versatile,and human-relevant models of neural development and brain diseases 认领 引用 被引量：3
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作者 Raquel Coronel Rosa González-Sastre +8 位作者 Patricia Mateos-Martínez Laura Maeso Elena Llorente-Beneyto Sabela Martín-Benito Viviana S.Costa Gagosian Leonardo Foti Ma Carmen González-Caballero Victoria López-Alonso Isabel Liste 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第3期837-854,共18页
The brain is the most complex human organ,and commonly used models,such as two-dimensional-cell cultures and animal brains,often lack the sophistication needed to accurately use in research.In this context,human cereb... The brain is the most complex human organ,and commonly used models,such as two-dimensional-cell cultures and animal brains,often lack the sophistication needed to accurately use in research.In this context,human cerebral organoids have emerged as valuable tools offering a more complex,versatile,and human-relevant system than traditional animal models,which are often unable to replicate the intricate architecture and functionality of the human brain.Since human cerebral organoids are a state-of-the-art model for the study of neurodevelopment and different pathologies affecting the brain,this field is currently under constant development,and work in this area is abundant.In this review,we give a complete overview of human cerebral organoids technology,starting from the different types of protocols that exist to generate different human cerebral organoids.We continue with the use of brain organoids for the study of brain pathologies,highlighting neurodevelopmental,psychiatric,neurodegenerative,brain tumor,and infectious diseases.Because of the potential value of human cerebral organoids,we describe their use in transplantation,drug screening,and toxicology assays.We also discuss the technologies available to study cell diversity and physiological characteristics of organoids.Finally,we summarize the limitations that currently exist in the field,such as the development of vasculature and microglia,and highlight some of the novel approaches being pursued through bioengineering. 展开更多
关键词 assembloids bioengineering challenges disease modeling drug screening and toxicology human brain organoids human pluripotent stem cells neurodegenerative diseases neurodevelopment vascularization
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Exercise training-induced extracellular miR-136-3p modulates glucose uptake and myogenesis through targeting of NRDC in human skeletal muscle 认领 引用 被引量：2
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作者 Mutsumi Katayama Elena Caria +8 位作者 Dimitri Van Simaeys Anna Yagüe Sanz Romain Barrès Kenneth Caidahl Oscar P.B.Wiklander Samir El Andaloussi Per-Olof Berggren Juleen R.Zierath Anna Krook 《Journal of Sport and Health Science》 SCIE CAS CSCD 2026年第1期40-55,共16页
Background Regular physical training induces adaptive effects across multiple organ systems,highlighting the existence of inter-organ communication networks.However,the molecular mechanisms underlying both exercise-in... Background Regular physical training induces adaptive effects across multiple organ systems,highlighting the existence of inter-organ communication networks.However,the molecular mechanisms underlying both exercise-induced adaptations and organ-to-organ signaling are not fully characterized.Circulating extracellular vesicles(EVs),including exosomes,carry molecules like microRNAs(miRNAs)that may mediate tissue crosstalk.This study aimed to identify specific exercise training-responsive miRNAs that affect skeletal muscle function.Methods miRNA expression profiles of serum-derived EVs were analyzed in healthy young individuals before and after 3 weeks endurance exercise training.Exercise training-responsive miRNAs were then validated for a functional role in cellular metabolic processes in human myotubes.Results We identified several exercise training-responsive miRNAs within exosome-rich EVs in serum,including miR-136-3p.In human myotubes,miR-136-3p enhanced glucose uptake and targeted the nardilysin convertase(NRDC)gene.Transfection of miR-136-3p or silencing of NRDC induced a shift towards glycolytic metabolism in mitochondria and modulated gene expressions related to myogenesis.Pancreatic islets were identified as a potential source of miR-136-3p based on in silico analysis of gene expression and a molecular analysis of conditioned media from isolated pancreatic islets.Conclusion MiR-136-3p is an endurance training-responsive molecular transducer that modulates glucose metabolism and cellular proliferation in myocytes.Associated with EVs,extracellular miR-136-3p may serve as a molecular messenger to communicate islet–skeletal muscle crosstalk after exercise.Extracellular miR-136-3p may serve as a molecular messenger to communicate islet–skeletal muscle crosstalk.Our results highlight a miRNA-mediated mechanism that participates in inter-organ communication to fine tune the metabolic adaptations to exercise. 展开更多
关键词 Extracellular miRNA Endurance training Human skeletal muscle miR-136-3p Nardilycin convertase(NRDC)
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Methods of preparation,structural characteristics of resistant starch and its relation to human health:a review 认领 引用 被引量：1
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作者 Weiyi Zhang Yang Yang +6 位作者 Chunmin Ma Bing Wang Xiaofei Liu Yan Wang Xin Bian Guang Zhang Na Zhang 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第4期1503-1519,共17页
Resistant starch(RS)comprises starch fractions that resist digestion in the small intestine and reach the colon,where they are fermented by the microbiota.Resistant starch harbors functional properties and healthpromo... Resistant starch(RS)comprises starch fractions that resist digestion in the small intestine and reach the colon,where they are fermented by the microbiota.Resistant starch harbors functional properties and healthpromoting ingredients that can regulate blood glucose and lipid levels,prevent cancer,and enhance the quality of life.Consequently,new technologies for the preparation of RS are continually being developed to support its industrial production.This review describes the structural and nutritional properties of RS and examines recent advancements in RS preparation methods.Emphasis is placed on how RS structure influences its properties and the physiological mechanisms in vivo.This review aims to stimulate further research into the preparation methods,functional characteristics,and utilization of RS,thereby supporting ongoing developments in the food industry. 展开更多
关键词 Resistant starch Preparation methods Characterization Function Human health
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Development of nontarget method based on GC-QTOF-HRMS for analyzing organic pollutants in human serum 认领 引用 被引量：1
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作者 Congcong Yue Chang He +5 位作者 Hailing Li Zhiquan Yuan Guiying Li Shengtao Ma Xin Zhang Taicheng An 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第7期379-386,共8页
Traditional targeted analyses often overlook unknown or emerging contaminants,highlighting the significance of nontarget and suspect screening approaches.A novel and high-sensitivity methodology for nontarget analysis... Traditional targeted analyses often overlook unknown or emerging contaminants,highlighting the significance of nontarget and suspect screening approaches.A novel and high-sensitivity methodology for nontarget analysis of organic pollutants in human serum was newly-developed based on gas chromatography coupled with quadrupole time-of-flight high-resolution mass spectrometry.The extraction protocol employing an acetonitrile-ethyl acetate(9:1,V:V)mixture significantly improved the extraction efficiency while minimizing matrix effect.A hybridized analytical strategy integrating nontarget and suspect screening was developed to achieve comprehensive identification and classification of pollutants,employing the National Institute of Standards and Technology(NIST)20 library and Agilent Technologies Personal Compound Database and Library(PCDL).This approach successfully characterized 273 organic contaminants spanning 12 categories,including polycyclic aromatic hydrocarbons(PAHs)and their derivatives,esters,and phenolic compounds in human serum,with a significant increase in detection specificity compared to conventional workflows.The methodology used serum samples of the workers from coking industry,revealing widespread contamination dominated by PAHs and PAH derivatives.Among the target analytes,three were identified solely by NIST and six solely by PCDL,indicating the complementary benefits of combining these different databases.Notably,this work reported the first confirmed detection of 2-naphthalenamine in human serum.This optimized approach demonstrates enhanced sensitivity and reliability in serum analysis,advancing biomonitoring capabilities and providing a deep understanding of human exposure to environmental pollutants. 展开更多
关键词 Nontarget analysis Biomonitoring method Human serum sample Organic pollutants GC-QTOF-HRMS
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Patterns,synergies,and interactions between human activities and living environment on the Qinghai-Xizang Plateau 认领 引用 被引量：1
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作者 GUO Changqing ZHANG Haiyan +2 位作者 DOU Yinyin KUANG Wenhui BAO Wenxuan 《Journal of Geographical Sciences》 SCIE CSCD 2026年第2期341-362,共22页
Understanding the impacts of human activities on the plateau’s living environment is essential for advancing modernization pathways that promote harmony between humanity and nature.However,studies on the dynamic inte... Understanding the impacts of human activities on the plateau’s living environment is essential for advancing modernization pathways that promote harmony between humanity and nature.However,studies on the dynamic interactions between human activities and the living environment on the Qinghai-Xizang Plateau(QXP)remain limited,with a paucity of quantitative relationship analyses.This study established an assessment framework to evaluate human influences on the living environment in QXP,using data on typical human activities,ecological conditions,and human settlements.Within this framework,the spatial analysis methods and the coupling coordination model were used to examine the spatio-temporal characteristics and relationship of human activities and living environment on the QXP from 2000 to 2020.The geographical detector model was then applied to identify the key factors influencing the plateau’s human living environment.Subsequently,the four-quadrant analysis model was adopted to assess human influences on the living environment.The results indicate that the human activity intensity(HAI)on the QXP remained relatively low yet increased by 15.41%from 2000 to 2020.Spatially,the human living environment quality(LEQ)improved from northwest to southeast,with 61.14%of the areas remaining stable and 18.47%experiencing slight improvement.The analysis of coupling coordination revealed a continuous improvement between the HAI and LEQ,with the areas of high and relatively high coordinated types increasing by more than 9%.Precipitation and urban-rural construction were identified as the primary factors influencing changes in the LEQ.The interaction between the HAI and LEQ was strengthening,with 40.44%classified as coordinated development type and 38.35%as development-environment conflict type.These findings provide valuable insights for enhancing the resilience of human settlements and promoting green development across the plateau. 展开更多
关键词 human activities living environment spatio-temporal characteristics coupling coordination influencing factor Qinghai-Xizang Plateau
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Deep Learning-Enhanced Human Sensing with Channel State Information: A Survey 认领 引用 被引量：1
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作者 Binglei Yue Aili Jiang +3 位作者 Chun Yang Junwei Lei Heng Liu Yin Zhang 《Computers, Materials & Continua》 SCIE EI 2026年第1期1-28,共28页
With the growing advancement of wireless communication technologies,WiFi-based human sensing has gained increasing attention as a non-intrusive and device-free solution.Among the available signal types,Channel State I... With the growing advancement of wireless communication technologies,WiFi-based human sensing has gained increasing attention as a non-intrusive and device-free solution.Among the available signal types,Channel State Information(CSI)offers fine-grained temporal,frequency,and spatial insights into multipath propagation,making it a crucial data source for human-centric sensing.Recently,the integration of deep learning has significantly improved the robustness and automation of feature extraction from CSI in complex environments.This paper provides a comprehensive review of deep learning-enhanced human sensing based on CSI.We first outline mainstream CSI acquisition tools and their hardware specifications,then provide a detailed discussion of preprocessing methods such as denoising,time–frequency transformation,data segmentation,and augmentation.Subsequently,we categorize deep learning approaches according to sensing tasks—namely detection,localization,and recognition—and highlight representative models across application scenarios.Finally,we examine key challenges including domain generalization,multi-user interference,and limited data availability,and we propose future research directions involving lightweight model deployment,multimodal data fusion,and semantic-level sensing. 展开更多
关键词 Channel State Information(CSI) human sensing human activity recognition deep learning
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ALDH2 in autophagy and cell death:molecular mechanisms and implications for diseases 认领 引用 被引量：1
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作者 Yu Duan Ze-Chen Shan +1 位作者 Jiao-Jiao Pang Yu-Guo Chen 《Military Medical Research》 SCIE CAS CSCD 2026年第2期239-266,共28页
Aldehyde dehydrogenase 2(ALDH2),a mitochondrial enzyme,is the main acetaldehyde dehydrogenase involved in the scavenging of alcohol-derived acetaldehyde and endogenous aldehydes.The ALDH2rs671mutation affects 560 m... Aldehyde dehydrogenase 2(ALDH2),a mitochondrial enzyme,is the main acetaldehyde dehydrogenase involved in the scavenging of alcohol-derived acetaldehyde and endogenous aldehydes.The ALDH2rs671mutation affects 560 million East Asians and is closely related to an increased risk of various human diseases.In addition to its well-known function in detoxifying alcohol-derived acetaldehyde and endogenous aldehydes,ALDH2 is implicated in human health through its regulation of autophagic machinery and multiple cell death pathways(e.g.,apoptosis,necroptosis,pyroptosis,ferroptosis,and NETosis).This review summarizes the current knowledge of ALDH2 and the regulatory mechanism through which ALDH2 regulates autophagy and cell death.In addition,we outline the potential role of ALDH2 in the regulation of autophagy and cell death during the occurrence and progression of human diseases,aiming to provide a novel theoretical framework for human disease treatment. 展开更多
关键词 Aldehyde dehydrogenase 2(ALDH2) Autophagy Cell death Human diseases
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Disservices in terrestrial and freshwater ecosystems.The negative side of the ecosystems 认领 引用 被引量：1
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作者 Paulo Pereira Emoke Dalma Kovacs +2 位作者 Melinda Haydee Kovacs Miguel Inácio Wenwu Zhao 《Geography and Sustainability》 CSCD 2026年第2期1-6,共6页
1.Background Ecosystems supply a wide range of goods and services.This has been an important research topic for decades,and numerous works have argued that ecosystems are key to human wellbeing(Pinto et al.,2022).The ... 1.Background Ecosystems supply a wide range of goods and services.This has been an important research topic for decades,and numerous works have argued that ecosystems are key to human wellbeing(Pinto et al.,2022).The ecosystem services(ES)concept emerged from the idea that humans depend on the environment and is defined as the bene fits people obtain from ecosystems(MEA,2005).Although there are different classifications,ES are normally divided into Regulating,Pro visioning,and Cultural. 展开更多
关键词 human wellbeing goods services terrestrial ecosystems bene fits people obtain ecosystem services concept freshwater ecosystems ecosystem services negative impacts
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Charting bioethical frontiers:China’s human organoid guidelines in a global context 认领 引用 被引量：1
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作者 Liang-Bin Zhou Yi-Ting Lei Xin-Xin Han 《Military Medical Research》 SCIE CAS CSCD 2026年第2期340-344,共5页
The rapid progress of human organoid toolkits presents unprecedented opportunities in disease modeling,drug discovery,and personalized therapy,alongside profound bioethical challenges and concerns.On April 29th,2025,C... The rapid progress of human organoid toolkits presents unprecedented opportunities in disease modeling,drug discovery,and personalized therapy,alongside profound bioethical challenges and concerns.On April 29th,2025,China’s National Science and Technology Ethics Committee(Life Science Ethics Subcommittee)issued the Human Organoid Research Ethical Guidelines[1],establishing the world’s first comprehensive governance framework,especially focusing on brain organoids,embryo models,and chimeric research.This Guidelines represent a pioneering governance model in emerging biotechnology.This commentary offers an in-depth analysis to examine the policy’s innovative three-tiered structure,contrast it with current global regulatory standards,evaluate its domestic impacts as well as potential implications for international biotechnology governance,and provide recommendations for future directions. 展开更多
关键词 Human organoids Regulatory policy Ethical guidelines Brain organoids Embryo models Organoid chimeras
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Human spinal cord organoids:A powerful tool to redefine gray matter and lower motor neuron pathophysiology in spinal cord injury 认领 引用 被引量：1
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作者 Maria Jose Quezada Colin K.Franz 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第5期2001-2002,共2页
Human spinal cord organoids(hSCOs)offer a promising platform to study neurotrauma by addressing many limitations of traditional research models.These organoids provide access to human-specific physiological and geneti... Human spinal cord organoids(hSCOs)offer a promising platform to study neurotrauma by addressing many limitations of traditional research models.These organoids provide access to human-specific physiological and genetic mechanisms and can be derived from an individual's somatic cells(e.g.,blood or skin).This enables patient-specific paradigms for precision neurotrauma research,pa rticula rly relevant to the over 300,000 people in the United States living with chronic effects of spinal cord injury(SCI). 展开更多
关键词 human spinal cord organoids study neurotrauma spinal cord injury human spinal cord organoids hscos offer somatic cells egblood spinal cord traditional research modelsthese neurotrauma
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Human exposure to neonicotinoid insecticides:Safe or not? 认领 引用
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作者 Yishuang Duan Zhen Sun +4 位作者 Xiaoran Zhang Pu Wang Yong Liang Qunfang Zhou Guibin Jiang 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第5期348-375,共28页
Neonicotinoid insecticides(NEOs)are a group of widely used insecticides in agriculture,livestock,and pest control for pets.However,increasing reports on their adverse effects on non-target organisms have aroused growi... Neonicotinoid insecticides(NEOs)are a group of widely used insecticides in agriculture,livestock,and pest control for pets.However,increasing reports on their adverse effects on non-target organisms have aroused growing public concerns.Therefore,it is necessary to evaluate NEO exposure and the related human health.This review summarized the human biomonitoring studies on NEOs,and the epidemiological,in vitro,and in vivo toxicological investigations on the health effects of NEOs.Human biomonitoring studies revealed significant changes in NEO detection frequencies,concentrations,and profiles across different human populations,suggesting potential variances in exposure patterns or metabolic processes.Certain metabolites may be more sensitive biomarkers than their parent molecules,as evidenced by higher levels of some NEO metabolites than those of their parent compounds.Although human epidemiological data has revealed associations between NEO exposure and diverse detrimental health outcomes including reproductive and developmental abnormalities,oxidative damage,etc.,the cross-sectional design of most studies cannot elucidate causality,necessitating further prospective research.In vitro and in vivo studies have shown various toxic effects of NEOs,including neurotoxicity,hepatotoxicity,reproductive toxicity,genotoxicity,etc.Further research on the molecular mechanisms beyond oxidative stress is worthwhile.Given metabolic activation,additional metabolites of both conventional and new generation NEOs as well as NEO-like compounds need to be determined,and their toxicities should be evaluated.This review can be contributed to the comprehensive understanding of the threat from extensive exposure to NEOs and proposed future research directions can aid to improve studies on health effects of NEOs. 展开更多
关键词 Neonicotinoid insecticides Human exposure Toxicity Human health
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