Human-elephant conflict(HEC)poses a major socio-ecological challenge across elephant range states.Since 2015,the National Forest Ecosystem Research Station of China based in Xishuangbanna has developed the Elephant Ea...Human-elephant conflict(HEC)poses a major socio-ecological challenge across elephant range states.Since 2015,the National Forest Ecosystem Research Station of China based in Xishuangbanna has developed the Elephant Early-warning System(EEWS),a novel approach that has demonstrably reduced the risk of HEC incidents-particularly those involving direct encounters between people and elephants.By dynamically maintaining safety buffers,this system safeguards endangered elephants while mitigating human safety risks during livelihood activities and ensuring uninterrupted elephant movement.Building upon the C4ISR framework(Command,Control,Communications,Computers,Intelligence,Surveillance,and Reconnaissance),EEWS integrates key technological and institutional innovations-including the widespread adoption of mobile internet,deployment of camera traps,use of drones,and cross-sectoral governance reforms.The EEWS’s conceptual framework and technical architecture have been already recognized by local government and are now being scaled up from Xishuangbanna to the entire Asian elephant range in China,establishing a replicable“China model”for achieving harmonious human-elephant coexistence.This study reviews the conceptual foundations,development,and field implementation of EEWS,and offers recommendations to guide future refinement and broader application.展开更多
Stem cell fate decisions are increasingly understood through the dynamic interplay of two fundamental stress-adaptive programs:the integrated stress response(ISR)and the senescence-associated secretory phenotype(SASP)...Stem cell fate decisions are increasingly understood through the dynamic interplay of two fundamental stress-adaptive programs:the integrated stress response(ISR)and the senescence-associated secretory phenotype(SASP).These pathways act as a Yin-Yang system,balancing beneficial and detrimental outcomes across development,tissue homeostasis,and disease.On the yin(protective)side,transient ISR activation and acute SASP signaling foster adaptation,embryonic patterning,wound healing,and regeneration.On the yang(maladaptive)side,chronic ISR signaling and unresolved SASP output drive stem cell exhaustion,fibrosis,inflammation,and tumorigenesis.This duality highlights their roles as both guardians and disruptors of stem cell integrity.Mechanistically,ISR regulates translational control via eukaryotic initiation factor 2 alpha(eIF2α)phosphorylation and activating transcription factor 4(ATF4)-dependent transcription,while SASP reprograms the extracellular milieu through cytokines,growth factors,and proteases.Their crosstalk creates feedback loops that shape tissue niches and long-termstemcell potential.Framing ISR-SASP interactions through a Yin-Yang lens underscores the balance between resilience and decline,to offer new insights into regenerative medicine,anti-aging interventions,and cancer therapeutics.展开更多
针对网络中心化C4ISR系统结构的定量设计与分析问题,以网络中心战结构模型和观察、调整、决策以及行动(observe,orient,decide,act,OODA)过程模型为理论依据,建立了系统结构"五环"概念,采用网络化效能因子(coefficient of net...针对网络中心化C4ISR系统结构的定量设计与分析问题,以网络中心战结构模型和观察、调整、决策以及行动(observe,orient,decide,act,OODA)过程模型为理论依据,建立了系统结构"五环"概念,采用网络化效能因子(coefficient of networked effectiveness,CNE)衡量系统结构的网络化效能,形成系统结构"五环"效能表征模型,并给出了指导网络中心化C4ISR系统结构设计的若干推论,仿真实验验证了表征模型的有效性。展开更多
An approach was proposed to specify the C4ISR capability of domain-specific modeling language.To confine the domain modeling within a standard architecture framework,formally a C4ISR capability meta-ontology was defin...An approach was proposed to specify the C4ISR capability of domain-specific modeling language.To confine the domain modeling within a standard architecture framework,formally a C4ISR capability meta-ontology was defined according to the meta-model of DoD Architecture Framework.The meta-ontology is used for extending UML Profile so that the domain experts can model the C4ISR domains using the C4ISR capability meta-concepts to define a domain-specific modeling language.The domain models can be then checked to guarantee the consistency and completeness through converting the UML models into the Description Logic ontology and making use of inference engine Pellet to verify the ontology.展开更多
基金funded by the Field Station Foundation of CAS,Lancang River Conservation Fund Project of SHANSHUI Conservation Center,the SEE Noah’s Ark Project of Beijing Entrepreneurs’Environmental Protection Foundation,the 14th Five-Year Plan of Xishuangbanna Tropical Botanical Garden(E3ZKFF9B01)the High-End Foreign Expert Recruitment Plan,Ministry of Science and Technology of the People’s Republic of China(E3YN105B01)the Yunnan Provincial Foreign Expert Project(202505AO120035).
摘要Human-elephant conflict(HEC)poses a major socio-ecological challenge across elephant range states.Since 2015,the National Forest Ecosystem Research Station of China based in Xishuangbanna has developed the Elephant Early-warning System(EEWS),a novel approach that has demonstrably reduced the risk of HEC incidents-particularly those involving direct encounters between people and elephants.By dynamically maintaining safety buffers,this system safeguards endangered elephants while mitigating human safety risks during livelihood activities and ensuring uninterrupted elephant movement.Building upon the C4ISR framework(Command,Control,Communications,Computers,Intelligence,Surveillance,and Reconnaissance),EEWS integrates key technological and institutional innovations-including the widespread adoption of mobile internet,deployment of camera traps,use of drones,and cross-sectoral governance reforms.The EEWS’s conceptual framework and technical architecture have been already recognized by local government and are now being scaled up from Xishuangbanna to the entire Asian elephant range in China,establishing a replicable“China model”for achieving harmonious human-elephant coexistence.This study reviews the conceptual foundations,development,and field implementation of EEWS,and offers recommendations to guide future refinement and broader application.
基金funded by the National Institutes of Health,grant numbers UG3OD023285,P42ES030991,and P30ES036084.
摘要Stem cell fate decisions are increasingly understood through the dynamic interplay of two fundamental stress-adaptive programs:the integrated stress response(ISR)and the senescence-associated secretory phenotype(SASP).These pathways act as a Yin-Yang system,balancing beneficial and detrimental outcomes across development,tissue homeostasis,and disease.On the yin(protective)side,transient ISR activation and acute SASP signaling foster adaptation,embryonic patterning,wound healing,and regeneration.On the yang(maladaptive)side,chronic ISR signaling and unresolved SASP output drive stem cell exhaustion,fibrosis,inflammation,and tumorigenesis.This duality highlights their roles as both guardians and disruptors of stem cell integrity.Mechanistically,ISR regulates translational control via eukaryotic initiation factor 2 alpha(eIF2α)phosphorylation and activating transcription factor 4(ATF4)-dependent transcription,while SASP reprograms the extracellular milieu through cytokines,growth factors,and proteases.Their crosstalk creates feedback loops that shape tissue niches and long-termstemcell potential.Framing ISR-SASP interactions through a Yin-Yang lens underscores the balance between resilience and decline,to offer new insights into regenerative medicine,anti-aging interventions,and cancer therapeutics.
摘要针对网络中心化C4ISR系统结构的定量设计与分析问题,以网络中心战结构模型和观察、调整、决策以及行动(observe,orient,decide,act,OODA)过程模型为理论依据,建立了系统结构"五环"概念,采用网络化效能因子(coefficient of networked effectiveness,CNE)衡量系统结构的网络化效能,形成系统结构"五环"效能表征模型,并给出了指导网络中心化C4ISR系统结构设计的若干推论,仿真实验验证了表征模型的有效性。
基金Project(2007AA01Z126) supported by the National High Technology Research and Development Program of ChinaProject(51306010202) supported by the National Defense Advance Research Program of China
摘要An approach was proposed to specify the C4ISR capability of domain-specific modeling language.To confine the domain modeling within a standard architecture framework,formally a C4ISR capability meta-ontology was defined according to the meta-model of DoD Architecture Framework.The meta-ontology is used for extending UML Profile so that the domain experts can model the C4ISR domains using the C4ISR capability meta-concepts to define a domain-specific modeling language.The domain models can be then checked to guarantee the consistency and completeness through converting the UML models into the Description Logic ontology and making use of inference engine Pellet to verify the ontology.