Dear Editor,The long-term use of copper(Cu)fungicides to prevent downy mildew of vine led to the accumulation of Cu in vineyard topsoils(Komárek et al.,2010;Droz et al.,2021),which may alter the functioning and s...Dear Editor,The long-term use of copper(Cu)fungicides to prevent downy mildew of vine led to the accumulation of Cu in vineyard topsoils(Komárek et al.,2010;Droz et al.,2021),which may alter the functioning and sustainability of vineyard ecosystems(Cornu et al.,2022).展开更多
Straw return has demonstrated significant potential for enhancing carbon(C)sequestration and nitrogen(N)uptake while concurrently promoting plant productivity.However,the specific transport and distribution of C produ...Straw return has demonstrated significant potential for enhancing carbon(C)sequestration and nitrogen(N)uptake while concurrently promoting plant productivity.However,the specific transport and distribution of C produced by photosynthesis and exogenous N within the rice plant-soil system under straw return remains unclear.A long-term straw return pot trial experiment was conducted in a double cropping rice system,incorporating treatments of inorganic fertilizer application with straw removal(F),straw burning and ash return with reducing inorganic fertilizers(SBR),and straw return with reducing inorganic fertilizers(SR)to investigate C sequestration and exogenous N uptake using 13C pulse and 15N isotope tracer techniques.The SR treatment had significantly higher soil 13C abundance,by 24.4 and 25.4%,respectively,13C concentrations in aboveground plant parts,by 18.4 and 35.8%respectively,and 15N concentrations in rice panicles,by 12.8 and 34.3%than the SBR and F treatments.This enhancement contributed to a higher total organic C concentration and increased rice grain yield in the SR treatment.Furthermore,the SR treatment had significantly higher photosynthetic C,by 9.8%,which was directly transferred to soil C.The SR treatment had a higher distribution of photosynthetic C in the leaves and stems,but a lower distribution in the panicle compared to the SBR treatment.This finding is advantageous for sequestering photosynthetic C into the soil through straw return;conversely,opposite trends were observed in 15N distribution.In addition,rice plants in the SR treatment had increased N uptake from urea and soil N sources,enhancing N recovery by 9.2 and 12.5%,respectively,and reducing soil N residues.Correlation analysis showed that the SR treatment increased the concentrations of 13C in leaves and roots while decreasing the 15N abundance in all rice organs,thereby contributing to an increase in rice yield.The partial least square path model suggested that the increase in rice yield under the SR treatment was primarily linked to 13C accumulation within the rice plant-soil system.The results suggest that straw return increases the sequestration of photosynthetic C and exogenous N in the rice plant-soil system and increases N utilization efficiency,which subsequently improves both rice and soil productivity.展开更多
Rapid growth of Moso bamboo(Phyllostachys edulis)shoots(offspring ramet)is primarily fuelled by nitrogen(N)derived from parent ramet and absorbed by rhizome roots.However,the extent to which each N source supports the...Rapid growth of Moso bamboo(Phyllostachys edulis)shoots(offspring ramet)is primarily fuelled by nitrogen(N)derived from parent ramet and absorbed by rhizome roots.However,the extent to which each N source supports the growth of offspring ramet and the underlying molecular mechanisms of N transport remain unclear.Here,clonal fragments consisting of a parent ramet,an offspring ramet,and an interconnected rhizome were established in a Moso bamboo forest.Additionally,15N isotope tracing and transcriptome profiling were conducted concurrently to quantify the N contribution from the parent ramet and rhizome roots to the offspring ramet,and to reveal the molecular mechanisms underlying N transport during rapid growth(i.e.early,peak,branching,and leafing stages).The N acquisition strategy of offspring ramet shifted from being primarily provided by the parent ramet(72.53%)during early stage to being predominantly absorbed by rhizome roots(69.85%)during the leafing stage.Approximately equal N contributions(45.82%54.18%)from the parent ramet and rhizome roots were observed during peak and branching stages.PeAAP29123 was identified as a key gene for N transport,being most closely correlated with 15N content.Biomolecular assays demonstrated that PeHDZ23987 could activate the expression of PeAAP29123 via two types of HD-motifs.Overexpression of PeHDZ23987 and PeAAP29123 significantly enhanced N starvation tolerance in transgenic rice with significantly improved N uptake efficiency.Our findings clarify the pattern and mechanisms of N supply for the rapid growth of Moso bamboo offspring ramet and provide transcriptomic evidence for long-distance N transport between clonal ramets.展开更多
Automated labelling of radiology reports using natural language processing allows for the labelling of ground truth for large datasets of radiological studies that are required for training of computer vision models.T...Automated labelling of radiology reports using natural language processing allows for the labelling of ground truth for large datasets of radiological studies that are required for training of computer vision models.This paper explains the necessary data preprocessing steps,reviews the main methods for automated labelling and compares their performance.There are four main methods of automated labelling,namely:(1)rules-based text-matching algorithms,(2)conventional machine learning models,(3)neural network models and(4)Bidirectional Encoder Representations from Transformers(BERT)models.Rules-based labellers perform a brute force search against manually curated keywords and are able to achieve high F1 scores.However,they require proper handling of negative words.Machine learning models require preprocessing that involves tokenization and vectorization of text into numerical vectors.Multilabel classification approaches are required in labelling radiology reports and conventional models can achieve good performance if they have large enough training sets.Deep learning models make use of connected neural networks,often a long short-term memory network,and are similarly able to achieve good performance if trained on a large data set.BERT is a transformer-based model that utilizes attention.Pretrained BERT models only require fine-tuning with small data sets.In particular,domain-specific BERT models can achieve superior performance compared with the other methods for automated labelling.展开更多
The labelling and imaging of tumor cells were investigated via arginine-glycine-aspartic acidcysteine(RGDC) peptide-labelled quantum dots(QDs). The results show that RGDC modified QDs can label SMMC-7721 tumor cel...The labelling and imaging of tumor cells were investigated via arginine-glycine-aspartic acidcysteine(RGDC) peptide-labelled quantum dots(QDs). The results show that RGDC modified QDs can label SMMC-7721 tumor cells and adhere to cellular membrane. In constrast, the unmodified QDs are mainly dispersed around the cell. We also found that the RGDC-QDs can penetrate into the cell at 2 h of incubation. After 6 h of incubation, RGDC-QDs can accumulate in a unique intracellular region.展开更多
MULTIPLE sclerosis (MS) is a common inflammatory demyelinating disorder of central nervous system, and the disease burder could be well evaluated by conven-tional magnetic resonance imaging (MRI),1 including T2-we...MULTIPLE sclerosis (MS) is a common inflammatory demyelinating disorder of central nervous system, and the disease burder could be well evaluated by conven-tional magnetic resonance imaging (MRI),1 including T2-weighted, fluid-attenuatd inversion recovery, and postcontrast Tl-weighted sequences. 2 We investigated the perfusion state of MS plaques using brain perfusion imaging in a 12-year-old boy with MS.展开更多
The Internet revolution has resulted in abundant data from various sources,including social media,traditional media,etcetera.Although the availability of data is no longer an issue,data labelling for exploiting it in ...The Internet revolution has resulted in abundant data from various sources,including social media,traditional media,etcetera.Although the availability of data is no longer an issue,data labelling for exploiting it in supervised machine learning is still an expensive process and involves tedious human efforts.The overall purpose of this study is to propose a strategy to automatically label the unlabeled textual data with the support of active learning in combination with deep learning.More specifically,this study assesses the performance of different active learning strategies in automatic labelling of the textual dataset at sentence and document levels.To achieve this objective,different experiments have been performed on the publicly available dataset.In first set of experiments,we randomly choose a subset of instances from training dataset and train a deep neural network to assess performance on test set.In the second set of experiments,we replace the random selection with different active learning strategies to choose a subset of the training dataset to train the same model and reassess its performance on test set.The experimental results suggest that different active learning strategies yield performance improvement of 7% on document level datasets and 3%on sentence level datasets for auto labelling.展开更多
An L(0,1)-labelling of a graph G is an assignment of nonnegative integers to the vertices of G such that the difference between the labels assigned to any two adjacent vertices is at least zero and the difference betw...An L(0,1)-labelling of a graph G is an assignment of nonnegative integers to the vertices of G such that the difference between the labels assigned to any two adjacent vertices is at least zero and the difference between the labels assigned to any two vertices which are at distance two is at least one. The span of an L(0,1)-labelling is the maximum label number assigned to any vertex of G. The L(0,1)-labelling number of a graph G, denoted by λ0.1(G) is the least integer k such that G has an L(0,1)-labelling of span k. This labelling has an application to a computer code assignment problem. The task is to assign integer control codes to a network of computer stations with distance restrictions. A cactus graph is a connected graph in which every block is either an edge or a cycle. In this paper, we label the vertices of a cactus graph by L(0,1)-labelling and have shown that, △-1≤λ0.1(G)≤△ for a cactus graph, where △ is the degree of the graph G.展开更多
This paper shows that, for every unit interval graph, there is a labelling which is simultaneously optimal for the following seven graph labelling problems: bandwidth, cyclic bandwidth, profile, fill-in, cutwidth, mod...This paper shows that, for every unit interval graph, there is a labelling which is simultaneously optimal for the following seven graph labelling problems: bandwidth, cyclic bandwidth, profile, fill-in, cutwidth, modified cutwidth, and bandwidth sum(linear arrangement).展开更多
The need to inform consumers about the health impact of their food choices is ever more pressing in a world where obesity is a growing problem. Concerns over food safety, its origins and its environmental impacts are ...The need to inform consumers about the health impact of their food choices is ever more pressing in a world where obesity is a growing problem. Concerns over food safety, its origins and its environmental impacts are also growing, as frequently reported in the popular press in many parts of the world. Nutritional and health information on food labels is quite well developed, but the complex nature of the information presented may hinder widespread use of the existing labels. In comparison, there has been little widespread success of carbon labels on food, and their usefulness in reducing carbon emissions from consumption is uncertain. In an attempt to address the need for clearer information on health and environmental impacts of food purchases, we present a novel dual-purpose food labelling system which provides information on both health and environmental impacts of food items. This paper presents results from a pilot study introducing a novel approach to food labelling: a simplified, combined carbon and health label to inform consumers simultaneously about the environmental and health impacts of their choices. Environmental impacts of various food categories were calculated on the basis of their relative energy use along the supply chain by using a newly designed Food Energy Index. Health impacts were based on the NuVal system developed in the USA in 2010. As part of the Norfolk Island Carbon and Health Evaluation study (NICHE), labels were designed, tested and displayed on 25 food categories for a 3-month period in the main supermarket on Norfolk Island (Australia). The in-store labelling trial was followed by a consumer survey on their attitudes to the labels. The results from this pilot trial indicate that consumers were supportive of food labelling including both environmental and health impacts, but the information provided in the dual labels was not sufficient to induce changes in consumption between food categories. We conclude that simple label design is clearly essential, and our findings warrant further investigation, including a broader study using a larger population and a wider range of food categories.展开更多
Building up graph models to simulate scale-free networks is an important method since graphs have been used in researching scale-free networks. One use labelled graphs for distinguishing objects of communication and i...Building up graph models to simulate scale-free networks is an important method since graphs have been used in researching scale-free networks. One use labelled graphs for distinguishing objects of communication and information networks. In this paper some methods are given for constructing larger felicitous graphs from smaller graphs having special felicitous labellings, and some network models are shown to be felicitous.展开更多
Developing precise extracellular vesicles(EVs)labelling techniques with minimal disturbance is of great importance to the follow-up EVs detection and analysis.However,currently available methods such as using probes t...Developing precise extracellular vesicles(EVs)labelling techniques with minimal disturbance is of great importance to the follow-up EVs detection and analysis.However,currently available methods such as using probes to conjugate phospholipids or membrane proteins have certain limitations due to EV steric hindrance,dye aggregation,etc.Here,we present a microfluidic platform to enhance EVs’labelling efficiency and improve their detection.This platform provides excellent sample throughput and high-efficiency EV labelling at lower label concentrations with an optimized flowing rate.Flow cytometry analysis(FCM)and cellular uptake results show that EV labelling by utilizing this platform possesses the merits of a higher labelling efficiency with 64.1%relative improvement than conventional co-incubation method and a lower background noise.Moreover,this technique maintains EVs’size,morphology and biological activities.After the recipient cells uptake the EVs treated by the microfluidic platform,the spatial and temporal distribution of EVs in the cells are clearly observed.These results demonstrate that our method holds great potential in efficient labelling of EVs,which is essential to subsequent EV quantification and analysis.展开更多
Condense matter methods and mathematical models used in solving problems in solid state physics are transformed to high energy quantum cosmology in order to estimate the magnitude of the missing dark energy of the uni...Condense matter methods and mathematical models used in solving problems in solid state physics are transformed to high energy quantum cosmology in order to estimate the magnitude of the missing dark energy of the universe. Looking at the problem from this novel viewpoint was rewarded by a rather unexpected result, namely that the gap labelling method of integrated density of states for three dimensional icosahedral quasicrystals is identical to the previously measured and theoretically concluded ordinary energy density of the universe, namely a mere 4.5 percent of Einstein’s energy density, i.e. E(O) = mc2/22 where E is the energy, m is the mass and c is the speed of light. Consequently we conclude that the missing dark energy density must be E(D) = 1 - E(O) = mc2(21/22) in agreement with all known cosmological measurements and observations. This result could also be interpreted as a strong evidence for the self similarity of the geometry of spacetime, which is an expression of its basic fractal nature.展开更多
This paper described the ~3H NMR determination of the positions and content of 24 tritium labeled aromatic and heterocyclic compounds prepared by catalytic tritiation derivatives, pyrrole, 1,2,4-triazole, thiazole, be...This paper described the ~3H NMR determination of the positions and content of 24 tritium labeled aromatic and heterocyclic compounds prepared by catalytic tritiation derivatives, pyrrole, 1,2,4-triazole, thiazole, benzothiazole, purine and derivatives, indole, indanol, piperidine and derivative, diphenylamine, N- phenylanthranilic acid, 8- OH- quinoline, naphthol, diphenylether have been tritiated by catalytic exchange method using tritiated water and platinum catalyst (from the dioxide and sodium borohydride), and the pattern of labelling has been assigned by ~3H NMR spectroscopy. The results show that this exchange process can give general labelling compounds at various time and temperatures. For 4-Br-diphenylether, Raney nickel was used instead of Pt as a catalyst.展开更多
Correct drug labelling is central for ensuring proper drug dispensing and thus for patient safety. Labelling errors may result in adverse health outcomes. The objective of this study was, therefore, to assess the effe...Correct drug labelling is central for ensuring proper drug dispensing and thus for patient safety. Labelling errors may result in adverse health outcomes. The objective of this study was, therefore, to assess the effect of labelling on the quality of drug dispensing and patient knowledge about dispensed drugs in Jimma University model and specialized hospital outpatient Pharmacies. Individual packages with prescribed drugs were examined using pretested questionnaire and observational check lists during the dispensing process. Patients’ knowledge about drugs dispensed to them was assessed at the exit interview using a pretested questionnaire. Out of 743 prescribed drugs, 682 (91.8%) were dispensed to 426 patients. The average labelling score (range from 0 to 6) of dispensed drugs in Model and Outpatient pharmacy was 2.00 (95% CI 1.97 to 2.04) and 1.73 (95% CI 1.6 to 1.8) respectively, with overall average labelling score of 1.90 (95% CI 1.84 to 1.91). The average patient knowledge score (range from 0 t0 5) was 3.45 (95% CI 3.31 to 3.59) and 3.5 (95% CI 3.35 to 3.64) for model and outpatient pharmacy, respectively, while the overall average knowledge score was 3.46 (95% CI 3.37 to 3.57). Major labelling problems were absence of patient’s name and dose followed by frequency of administration, duration of treatment, and the reason for prescription. Literacy status of patients had a significant effect on their knowledge (p 0.05). We recommend that corrective measures targeting both, labelling and patients’ knowledge should be implemented to improve the patients’ safety and drug therapy adherence.展开更多
The aim of the research was to examine ewe and goat cheese labelling on the market of the Republic of Croatia. During the four years (2012-2016) of the research, 133 cheeses from retail supermarket chains were selecte...The aim of the research was to examine ewe and goat cheese labelling on the market of the Republic of Croatia. During the four years (2012-2016) of the research, 133 cheeses from retail supermarket chains were selected by the random-choice method by the responsible inspection of the Republic of Croatia and analysed at the Reference Laboratory for Milk and Dairy Products of the Department of Dairy Science at the Faculty of Agriculture University of Zagreb. To check the correct labelling of cheeses, the chemical composition of cheese was examined: the fat content, the dry matter content, the fat in dry matter content, and the water content in the fat-free cheese compound were calculated according to the Ordinance on Cheeses and Cheese Products, which refers to cheeses manufactured in the Republic of Croatia, and Regulation EU (2011) of the European Parliament and the Council on providing information to consumers about food products, which covers foreign cheeses. The presence of cow milk in cheeses labelled as products manufactured exclusively from ewe or goat milk was tested by the reference method using iso-electric focusing to determine any adulteration according to Commission Regulation (2008). The results of analysis in this research show the condition of the quality and correct labelling of ewe and goat cheeses on the market of the Republic of Croatia. Of the 133 cheeses analysed, 67 cheeses (50%) did not correspond to the values stated on the declaration or to legal regulations, while the presence of cow milk was found in 30% of the cheeses analysed. The research results indicate the need to carry out continuous systematic control in the interest of protecting consumers and those manufacturers who are following good manufacturing practices.展开更多
A recently discovered approach including de Brujin graphs and Eulerian circuits are used to DNA sequencing and fragment assembly, and to simplify DNA graphs through a series of transformations on graphs and digraphs i...A recently discovered approach including de Brujin graphs and Eulerian circuits are used to DNA sequencing and fragment assembly, and to simplify DNA graphs through a series of transformations on graphs and digraphs in the field of bioinformatics. Since numbered graphs provide underlying mathematical models in studying the wide variety of seemingly unrelated practical applications, so graph colorings often are used to divide large systems into subsystems. A new graph labeling has been introduced and investigated.展开更多
Objective To study the relationship between apoptosis and hypertrophy of the left ventricie (LV) before and after its regression with antihypertensive treatment. Methods Forty 12- week old spontaneously. hypertensive ...Objective To study the relationship between apoptosis and hypertrophy of the left ventricie (LV) before and after its regression with antihypertensive treatment. Methods Forty 12- week old spontaneously. hypertensive rats(SHR were randomly divided into 2 groups, one given enalapril (SHR - d grouP) and the other without treatment (SHR group). Twenty normotensive Wistar Kyoto rats of the same age served as controls (WKY group). The changes of body weight and blood pressure were observed for 3 months. The rats were killed at the 24th week of age. The weight of LV, the body weight (B W), and the ratio of LV/BW were compared between the groups. Then by in situ specific labelling of nuclear DNA fragmentation, the apoptosis in the wall of the left ventricle was compared between them. RcsuIts The index of apoptosis was SHR - d>SHR> WKY The dofference was significant. ConcIusion The hypertrophy of the LV and its regression is very’likely related with the imbalance between the proloferation and death of cells of the muscle in the LV.展开更多
In this study,the nitrogen removal performance of partial denitrificaiton/anammox(PDA)process was investigated by using an UASB reactor.High total nitrogen(TN)removal efficiency(91.97%)was achieved at an influent nitr...In this study,the nitrogen removal performance of partial denitrificaiton/anammox(PDA)process was investigated by using an UASB reactor.High total nitrogen(TN)removal efficiency(91.97%)was achieved at an influent nitrogen loading rate of 0.64 kg/(m3·d).Anammox bacteria did execute the function of converting nitrate to nitrite in PDA system according to 15N isotope labeling experiments and the contribution was approximately 36.3%.Candidatus_Brocadia,Candidatus_Kuenenia and Thauera were functional strains for anammox and denitrification process,respectively.Thauera and Candidatus_Brocadia were more important for TN removal at high loading rates(0.64 kg/(m3·d)).This result can provide a theoretical and technical foundation for the application of the PDA process.展开更多
基金financially supported by the Bordeaux Wine Interprofessional Council(French acronym CIVB)in the framework of the EXTRACUIVRE projectby the French National Research Institute for Agriculture,Food and Environment(INRAE)in the framework of the COPOFTEA projectpartially supported by the TSU Program Priority 2030,Russia。
摘要Dear Editor,The long-term use of copper(Cu)fungicides to prevent downy mildew of vine led to the accumulation of Cu in vineyard topsoils(Komárek et al.,2010;Droz et al.,2021),which may alter the functioning and sustainability of vineyard ecosystems(Cornu et al.,2022).
基金supported by the National Natural Science Foundation of China(32160503)the Earmarked Fund for Jiangxi Agriculture Research System,China(JXARS-01)the National Key R&D Program of China(2023YFD2301303).
摘要Straw return has demonstrated significant potential for enhancing carbon(C)sequestration and nitrogen(N)uptake while concurrently promoting plant productivity.However,the specific transport and distribution of C produced by photosynthesis and exogenous N within the rice plant-soil system under straw return remains unclear.A long-term straw return pot trial experiment was conducted in a double cropping rice system,incorporating treatments of inorganic fertilizer application with straw removal(F),straw burning and ash return with reducing inorganic fertilizers(SBR),and straw return with reducing inorganic fertilizers(SR)to investigate C sequestration and exogenous N uptake using 13C pulse and 15N isotope tracer techniques.The SR treatment had significantly higher soil 13C abundance,by 24.4 and 25.4%,respectively,13C concentrations in aboveground plant parts,by 18.4 and 35.8%respectively,and 15N concentrations in rice panicles,by 12.8 and 34.3%than the SBR and F treatments.This enhancement contributed to a higher total organic C concentration and increased rice grain yield in the SR treatment.Furthermore,the SR treatment had significantly higher photosynthetic C,by 9.8%,which was directly transferred to soil C.The SR treatment had a higher distribution of photosynthetic C in the leaves and stems,but a lower distribution in the panicle compared to the SBR treatment.This finding is advantageous for sequestering photosynthetic C into the soil through straw return;conversely,opposite trends were observed in 15N distribution.In addition,rice plants in the SR treatment had increased N uptake from urea and soil N sources,enhancing N recovery by 9.2 and 12.5%,respectively,and reducing soil N residues.Correlation analysis showed that the SR treatment increased the concentrations of 13C in leaves and roots while decreasing the 15N abundance in all rice organs,thereby contributing to an increase in rice yield.The partial least square path model suggested that the increase in rice yield under the SR treatment was primarily linked to 13C accumulation within the rice plant-soil system.The results suggest that straw return increases the sequestration of photosynthetic C and exogenous N in the rice plant-soil system and increases N utilization efficiency,which subsequently improves both rice and soil productivity.
基金the National Natural Science Foundation of China(31930075,32125027,32101493)Scientific Research Foundation of Zhejiang A&F University(2022LFR006).
摘要Rapid growth of Moso bamboo(Phyllostachys edulis)shoots(offspring ramet)is primarily fuelled by nitrogen(N)derived from parent ramet and absorbed by rhizome roots.However,the extent to which each N source supports the growth of offspring ramet and the underlying molecular mechanisms of N transport remain unclear.Here,clonal fragments consisting of a parent ramet,an offspring ramet,and an interconnected rhizome were established in a Moso bamboo forest.Additionally,15N isotope tracing and transcriptome profiling were conducted concurrently to quantify the N contribution from the parent ramet and rhizome roots to the offspring ramet,and to reveal the molecular mechanisms underlying N transport during rapid growth(i.e.early,peak,branching,and leafing stages).The N acquisition strategy of offspring ramet shifted from being primarily provided by the parent ramet(72.53%)during early stage to being predominantly absorbed by rhizome roots(69.85%)during the leafing stage.Approximately equal N contributions(45.82%54.18%)from the parent ramet and rhizome roots were observed during peak and branching stages.PeAAP29123 was identified as a key gene for N transport,being most closely correlated with 15N content.Biomolecular assays demonstrated that PeHDZ23987 could activate the expression of PeAAP29123 via two types of HD-motifs.Overexpression of PeHDZ23987 and PeAAP29123 significantly enhanced N starvation tolerance in transgenic rice with significantly improved N uptake efficiency.Our findings clarify the pattern and mechanisms of N supply for the rapid growth of Moso bamboo offspring ramet and provide transcriptomic evidence for long-distance N transport between clonal ramets.
基金National Natural Science Foundation of China(No.10671074 and No.60673048)Natural Science Foundation of Education Ministry of Anhui Province(No.KJ2007B124 and No.2006KJ256B)
摘要Automated labelling of radiology reports using natural language processing allows for the labelling of ground truth for large datasets of radiological studies that are required for training of computer vision models.This paper explains the necessary data preprocessing steps,reviews the main methods for automated labelling and compares their performance.There are four main methods of automated labelling,namely:(1)rules-based text-matching algorithms,(2)conventional machine learning models,(3)neural network models and(4)Bidirectional Encoder Representations from Transformers(BERT)models.Rules-based labellers perform a brute force search against manually curated keywords and are able to achieve high F1 scores.However,they require proper handling of negative words.Machine learning models require preprocessing that involves tokenization and vectorization of text into numerical vectors.Multilabel classification approaches are required in labelling radiology reports and conventional models can achieve good performance if they have large enough training sets.Deep learning models make use of connected neural networks,often a long short-term memory network,and are similarly able to achieve good performance if trained on a large data set.BERT is a transformer-based model that utilizes attention.Pretrained BERT models only require fine-tuning with small data sets.In particular,domain-specific BERT models can achieve superior performance compared with the other methods for automated labelling.
基金Supported by the National Natural Science Foundation of China(Nos.30970719, 21043002)the Social Development Project of Science and Technology Department of Jilin Province, China(Nos.20106031, 20090133)+1 种基金the Project of Science and Technology Department of Changchun City, China(No.09SF02)the Fundamental Research Funds of Jilin University, China (No.200903098)
摘要The labelling and imaging of tumor cells were investigated via arginine-glycine-aspartic acidcysteine(RGDC) peptide-labelled quantum dots(QDs). The results show that RGDC modified QDs can label SMMC-7721 tumor cells and adhere to cellular membrane. In constrast, the unmodified QDs are mainly dispersed around the cell. We also found that the RGDC-QDs can penetrate into the cell at 2 h of incubation. After 6 h of incubation, RGDC-QDs can accumulate in a unique intracellular region.
摘要MULTIPLE sclerosis (MS) is a common inflammatory demyelinating disorder of central nervous system, and the disease burder could be well evaluated by conven-tional magnetic resonance imaging (MRI),1 including T2-weighted, fluid-attenuatd inversion recovery, and postcontrast Tl-weighted sequences. 2 We investigated the perfusion state of MS plaques using brain perfusion imaging in a 12-year-old boy with MS.
基金the Deanship of Scientific Research at Shaqra University for supporting this work.
摘要The Internet revolution has resulted in abundant data from various sources,including social media,traditional media,etcetera.Although the availability of data is no longer an issue,data labelling for exploiting it in supervised machine learning is still an expensive process and involves tedious human efforts.The overall purpose of this study is to propose a strategy to automatically label the unlabeled textual data with the support of active learning in combination with deep learning.More specifically,this study assesses the performance of different active learning strategies in automatic labelling of the textual dataset at sentence and document levels.To achieve this objective,different experiments have been performed on the publicly available dataset.In first set of experiments,we randomly choose a subset of instances from training dataset and train a deep neural network to assess performance on test set.In the second set of experiments,we replace the random selection with different active learning strategies to choose a subset of the training dataset to train the same model and reassess its performance on test set.The experimental results suggest that different active learning strategies yield performance improvement of 7% on document level datasets and 3%on sentence level datasets for auto labelling.
摘要An L(0,1)-labelling of a graph G is an assignment of nonnegative integers to the vertices of G such that the difference between the labels assigned to any two adjacent vertices is at least zero and the difference between the labels assigned to any two vertices which are at distance two is at least one. The span of an L(0,1)-labelling is the maximum label number assigned to any vertex of G. The L(0,1)-labelling number of a graph G, denoted by λ0.1(G) is the least integer k such that G has an L(0,1)-labelling of span k. This labelling has an application to a computer code assignment problem. The task is to assign integer control codes to a network of computer stations with distance restrictions. A cactus graph is a connected graph in which every block is either an edge or a cycle. In this paper, we label the vertices of a cactus graph by L(0,1)-labelling and have shown that, △-1≤λ0.1(G)≤△ for a cactus graph, where △ is the degree of the graph G.
摘要This paper shows that, for every unit interval graph, there is a labelling which is simultaneously optimal for the following seven graph labelling problems: bandwidth, cyclic bandwidth, profile, fill-in, cutwidth, modified cutwidth, and bandwidth sum(linear arrangement).
摘要The need to inform consumers about the health impact of their food choices is ever more pressing in a world where obesity is a growing problem. Concerns over food safety, its origins and its environmental impacts are also growing, as frequently reported in the popular press in many parts of the world. Nutritional and health information on food labels is quite well developed, but the complex nature of the information presented may hinder widespread use of the existing labels. In comparison, there has been little widespread success of carbon labels on food, and their usefulness in reducing carbon emissions from consumption is uncertain. In an attempt to address the need for clearer information on health and environmental impacts of food purchases, we present a novel dual-purpose food labelling system which provides information on both health and environmental impacts of food items. This paper presents results from a pilot study introducing a novel approach to food labelling: a simplified, combined carbon and health label to inform consumers simultaneously about the environmental and health impacts of their choices. Environmental impacts of various food categories were calculated on the basis of their relative energy use along the supply chain by using a newly designed Food Energy Index. Health impacts were based on the NuVal system developed in the USA in 2010. As part of the Norfolk Island Carbon and Health Evaluation study (NICHE), labels were designed, tested and displayed on 25 food categories for a 3-month period in the main supermarket on Norfolk Island (Australia). The in-store labelling trial was followed by a consumer survey on their attitudes to the labels. The results from this pilot trial indicate that consumers were supportive of food labelling including both environmental and health impacts, but the information provided in the dual labels was not sufficient to induce changes in consumption between food categories. We conclude that simple label design is clearly essential, and our findings warrant further investigation, including a broader study using a larger population and a wider range of food categories.
摘要Building up graph models to simulate scale-free networks is an important method since graphs have been used in researching scale-free networks. One use labelled graphs for distinguishing objects of communication and information networks. In this paper some methods are given for constructing larger felicitous graphs from smaller graphs having special felicitous labellings, and some network models are shown to be felicitous.
基金supported by the National Natural Science Foundation of China(Nos.62074155,62204253 and 62205366)Guangdong Program(No.2016ZT06D631)+1 种基金Guangdong Basic and Applied Basic Research Foundation(Nos.2020A1515110938 and 2020A1515110142)Shenzhen Science and Technology Innovation Committee(Nos.KCXFZ202002011008124 and JCYJ20210324101405016)。
摘要Developing precise extracellular vesicles(EVs)labelling techniques with minimal disturbance is of great importance to the follow-up EVs detection and analysis.However,currently available methods such as using probes to conjugate phospholipids or membrane proteins have certain limitations due to EV steric hindrance,dye aggregation,etc.Here,we present a microfluidic platform to enhance EVs’labelling efficiency and improve their detection.This platform provides excellent sample throughput and high-efficiency EV labelling at lower label concentrations with an optimized flowing rate.Flow cytometry analysis(FCM)and cellular uptake results show that EV labelling by utilizing this platform possesses the merits of a higher labelling efficiency with 64.1%relative improvement than conventional co-incubation method and a lower background noise.Moreover,this technique maintains EVs’size,morphology and biological activities.After the recipient cells uptake the EVs treated by the microfluidic platform,the spatial and temporal distribution of EVs in the cells are clearly observed.These results demonstrate that our method holds great potential in efficient labelling of EVs,which is essential to subsequent EV quantification and analysis.
摘要Condense matter methods and mathematical models used in solving problems in solid state physics are transformed to high energy quantum cosmology in order to estimate the magnitude of the missing dark energy of the universe. Looking at the problem from this novel viewpoint was rewarded by a rather unexpected result, namely that the gap labelling method of integrated density of states for three dimensional icosahedral quasicrystals is identical to the previously measured and theoretically concluded ordinary energy density of the universe, namely a mere 4.5 percent of Einstein’s energy density, i.e. E(O) = mc2/22 where E is the energy, m is the mass and c is the speed of light. Consequently we conclude that the missing dark energy density must be E(D) = 1 - E(O) = mc2(21/22) in agreement with all known cosmological measurements and observations. This result could also be interpreted as a strong evidence for the self similarity of the geometry of spacetime, which is an expression of its basic fractal nature.
摘要This paper described the ~3H NMR determination of the positions and content of 24 tritium labeled aromatic and heterocyclic compounds prepared by catalytic tritiation derivatives, pyrrole, 1,2,4-triazole, thiazole, benzothiazole, purine and derivatives, indole, indanol, piperidine and derivative, diphenylamine, N- phenylanthranilic acid, 8- OH- quinoline, naphthol, diphenylether have been tritiated by catalytic exchange method using tritiated water and platinum catalyst (from the dioxide and sodium borohydride), and the pattern of labelling has been assigned by ~3H NMR spectroscopy. The results show that this exchange process can give general labelling compounds at various time and temperatures. For 4-Br-diphenylether, Raney nickel was used instead of Pt as a catalyst.
摘要Correct drug labelling is central for ensuring proper drug dispensing and thus for patient safety. Labelling errors may result in adverse health outcomes. The objective of this study was, therefore, to assess the effect of labelling on the quality of drug dispensing and patient knowledge about dispensed drugs in Jimma University model and specialized hospital outpatient Pharmacies. Individual packages with prescribed drugs were examined using pretested questionnaire and observational check lists during the dispensing process. Patients’ knowledge about drugs dispensed to them was assessed at the exit interview using a pretested questionnaire. Out of 743 prescribed drugs, 682 (91.8%) were dispensed to 426 patients. The average labelling score (range from 0 to 6) of dispensed drugs in Model and Outpatient pharmacy was 2.00 (95% CI 1.97 to 2.04) and 1.73 (95% CI 1.6 to 1.8) respectively, with overall average labelling score of 1.90 (95% CI 1.84 to 1.91). The average patient knowledge score (range from 0 t0 5) was 3.45 (95% CI 3.31 to 3.59) and 3.5 (95% CI 3.35 to 3.64) for model and outpatient pharmacy, respectively, while the overall average knowledge score was 3.46 (95% CI 3.37 to 3.57). Major labelling problems were absence of patient’s name and dose followed by frequency of administration, duration of treatment, and the reason for prescription. Literacy status of patients had a significant effect on their knowledge (p 0.05). We recommend that corrective measures targeting both, labelling and patients’ knowledge should be implemented to improve the patients’ safety and drug therapy adherence.
基金part of the research project entitled“Quality control of cheeses on the market aimed at increasing competitiveness”financed by the Ministry of Agriculture,Agricultural Research Council(Project No.2012-11-27)acknowledge for supplying cheese samples and for financially support to the Ministry of Agriculture of Republic of Croatia.
摘要The aim of the research was to examine ewe and goat cheese labelling on the market of the Republic of Croatia. During the four years (2012-2016) of the research, 133 cheeses from retail supermarket chains were selected by the random-choice method by the responsible inspection of the Republic of Croatia and analysed at the Reference Laboratory for Milk and Dairy Products of the Department of Dairy Science at the Faculty of Agriculture University of Zagreb. To check the correct labelling of cheeses, the chemical composition of cheese was examined: the fat content, the dry matter content, the fat in dry matter content, and the water content in the fat-free cheese compound were calculated according to the Ordinance on Cheeses and Cheese Products, which refers to cheeses manufactured in the Republic of Croatia, and Regulation EU (2011) of the European Parliament and the Council on providing information to consumers about food products, which covers foreign cheeses. The presence of cow milk in cheeses labelled as products manufactured exclusively from ewe or goat milk was tested by the reference method using iso-electric focusing to determine any adulteration according to Commission Regulation (2008). The results of analysis in this research show the condition of the quality and correct labelling of ewe and goat cheeses on the market of the Republic of Croatia. Of the 133 cheeses analysed, 67 cheeses (50%) did not correspond to the values stated on the declaration or to legal regulations, while the presence of cow milk was found in 30% of the cheeses analysed. The research results indicate the need to carry out continuous systematic control in the interest of protecting consumers and those manufacturers who are following good manufacturing practices.
摘要A recently discovered approach including de Brujin graphs and Eulerian circuits are used to DNA sequencing and fragment assembly, and to simplify DNA graphs through a series of transformations on graphs and digraphs in the field of bioinformatics. Since numbered graphs provide underlying mathematical models in studying the wide variety of seemingly unrelated practical applications, so graph colorings often are used to divide large systems into subsystems. A new graph labeling has been introduced and investigated.
摘要Objective To study the relationship between apoptosis and hypertrophy of the left ventricie (LV) before and after its regression with antihypertensive treatment. Methods Forty 12- week old spontaneously. hypertensive rats(SHR were randomly divided into 2 groups, one given enalapril (SHR - d grouP) and the other without treatment (SHR group). Twenty normotensive Wistar Kyoto rats of the same age served as controls (WKY group). The changes of body weight and blood pressure were observed for 3 months. The rats were killed at the 24th week of age. The weight of LV, the body weight (B W), and the ratio of LV/BW were compared between the groups. Then by in situ specific labelling of nuclear DNA fragmentation, the apoptosis in the wall of the left ventricle was compared between them. RcsuIts The index of apoptosis was SHR - d>SHR> WKY The dofference was significant. ConcIusion The hypertrophy of the LV and its regression is very’likely related with the imbalance between the proloferation and death of cells of the muscle in the LV.
基金supported by the Natural Science Foundation of Shandong Province (ZR2019MEE038)the Fundamental Research Funds for the Central Universities (19CX02038A)the Key R&D Program of Shandong Province (Major Scientific and Technological Innovation Project 2019JZZY020502)
摘要In this study,the nitrogen removal performance of partial denitrificaiton/anammox(PDA)process was investigated by using an UASB reactor.High total nitrogen(TN)removal efficiency(91.97%)was achieved at an influent nitrogen loading rate of 0.64 kg/(m3·d).Anammox bacteria did execute the function of converting nitrate to nitrite in PDA system according to 15N isotope labeling experiments and the contribution was approximately 36.3%.Candidatus_Brocadia,Candidatus_Kuenenia and Thauera were functional strains for anammox and denitrification process,respectively.Thauera and Candidatus_Brocadia were more important for TN removal at high loading rates(0.64 kg/(m3·d)).This result can provide a theoretical and technical foundation for the application of the PDA process.