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Operational challenges and mitigation strategies in preparing malaria quality control panels 认领 引用
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作者 Naseem Ahmed Supriya Sharma +2 位作者 Piyush Choudhary Anupkumar Anvikar Praveen Kumar Bharti 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2026年第7期285-287,共3页
Over the past decades,rapid diagnostic tests(RDTs)have become the most widely deployed diagnostic tool,enabling timely treatment in resource-limited and remote settings[1].Their reliability,however,depends on rigorous... Over the past decades,rapid diagnostic tests(RDTs)have become the most widely deployed diagnostic tool,enabling timely treatment in resource-limited and remote settings[1].Their reliability,however,depends on rigorous quality assurance frameworks,with the World Health Organization(WHO)-endorsed quality control panels serving as the cornerstone for monitoring RDT performance and ensuring diagnostic fidelity across diverse epidemiological landscapes[2].Quality control panels are standardized,parasite-based reference materials used to evaluate antigen detection by RDTs under controlled conditions.They play an essential role in detecting lot-to-lot variations,guiding procurement decisions,and safeguarding programmatic confidence in RDTs[3].Despite this centrality,the practical and operational realities of quality control panel preparation in malaria-endemic regions remain underexplored. 展开更多
关键词 diagnostic tests rdts mitigation strategies malaria quality control panels quality assurance frameworkswith quality control panels control panels operational challenges timely treatment
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Advancing Plasmodium vivax malaria treatment in India:The vital role of glucose 6-phosphate dehydrogenase point-of-care tests 认领 引用
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作者 Nitika Nitika Praveen Kumar Bharti 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2026年第2期49-50,共2页
For India to achieve elimination by 2030,the challenges posed by Plasmodium(P.)vivax cannot be overlooked owing to its burden and unique biology.In 2023,in India,about 224000 malaria cases were reported,and a signific... For India to achieve elimination by 2030,the challenges posed by Plasmodium(P.)vivax cannot be overlooked owing to its burden and unique biology.In 2023,in India,about 224000 malaria cases were reported,and a significant proportion(40%)were P.vivax cases.In P.vivax infection,the persistence of dormant liver stage of parasite,i.e.,hypnozoites,leading to relapses weeks or months later poses challenge in its elimination. 展开更多
关键词 plasmodium vivax elimination hypnozoites relapses point care tests malaria treatment glucose phosphate dehydrogenase dormant liver stage
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Integrated Predictive Nursing Care for a Case of Imported Severe Malignant Malaria with Spontaneous Splenic Rupture 认领 引用
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作者 Na Bai Jing Wu +1 位作者 Lili Tian Wenting Li 《Journal of Clinical and Nursing Research》 2026年第1期181-192,共12页
A case of imported severe falciparum malaria with spontaneous splenic rupture was reported in this paper.The patient,an African migrant worker,developed hemolytic anemia,sepsis,thrombocytopenia,coagulation dysfunction... A case of imported severe falciparum malaria with spontaneous splenic rupture was reported in this paper.The patient,an African migrant worker,developed hemolytic anemia,sepsis,thrombocytopenia,coagulation dysfunction,liver failure,renal insufficiency,electrolyte disturbance and other clinical manifestations after returning to the local area.Plasmodium falciparum was found by peripheral blood smearscopy and was diagnosed as severe falciparum malaria.After standardized anti-malaria treatment,plasma exchange+cytokine adsorption therapy,the establishment of“forewarning-forewarning-prevention-emergency”predictive nursing management model,the establishment of an integrated nursing team,the division of medical care is clear,professional knowledge is complementary,after three months of regular follow-up,the patient has no malaria recurrence,no refire,the function of all organs returned to normal. 展开更多
关键词 Severe falciparum malaria Imported malaria Splenorrhagia Integration of health care Predictive care Plasma exchange Cytokine adsorption
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Microscopy and molecular approaches:A combined diagnostic framework for malaria surveillance in Malaysia 认领 引用
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作者 Kumuthamalar Sangaran Si Jie Goh +2 位作者 Ameera Aleeshya Mohd Fadrul Izwan Guan Min Wee Zulkarnain Md Idris 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2026年第5期193-195,共3页
By 2024,Malaysia achieved a significant public health milestone by marking its seventh consecutive year without a single local transmission of indigenous human Plasmodium species.The country has sustained elimination ... By 2024,Malaysia achieved a significant public health milestone by marking its seventh consecutive year without a single local transmission of indigenous human Plasmodium species.The country has sustained elimination of non-zoonotic malaria,primarily caused by Plasmodium(P.)falciparum and P.vivax,while remaining vigilant against imported and introduced cases driven by cross-border movement and international travel.However,despite this achievement,Malaysia has emerged as the global epicentre of zoonotic for P.knowlesi. 展开更多
关键词 indigenous human plasmodium species p vivax Malaysia malaria surveillance molecular approaches elimination microscopy imported cases
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Machine learning models to predict the risk of malaria outbreaks using balanced climatic and non-climatic data 认领 引用
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作者 Nwawudu Sixtus Ezenwa Pedro Latorre-Carmona J.Salvador Sánchez 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2026年第3期129-137,共9页
Objective:To predict malaria outbreaks early and accurately using machine learning models when data presents challenges such as imbalance.Methods:To predict the risk of malaria outbreaks,we applied six machine learnin... Objective:To predict malaria outbreaks early and accurately using machine learning models when data presents challenges such as imbalance.Methods:To predict the risk of malaria outbreaks,we applied six machine learning models-including naive Bayes,logistic regression,random forest,K-nearest neighbors,decision tree,and extreme gradient boosting-to a dataset of 8000 samples with 17 climatic and non-climatic features.To address class imbalance,we used the Synthetic Minority Over-sampling Technique algorithm.The models were evaluated using 10-fold cross-validation repeated 10 times to ensure robust validation.Results:Extreme gradient boosting achieved the highest F1-score,improving from 0.926 on imbalanced data to 0.991 after balancing.While random forest,naive Bayes,and decision tree also improved their performance when balancing data with Synthetic Minority Over-sampling Technique(increasing F1-score from 0.893 to 0.931,from 0.765 to 0.962,and from 0.785 to 0.812,respectively),logistic regression and K-nearest neighbors did not show any improvement.Conclusions:These findings demonstrate that integrating balanced climatic and non-climatic data with advanced machine learning can improve malaria outbreak risk prediction and support public health strategies. 展开更多
关键词 Malaria outbreak prediction Machine learning Data imbalance Public health Synthetic Minority Over-sampling Technique
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Erratum:Insecticide resistance status of malaria vectors in endemic states of India(2017-2024):A scoping review 认领 引用
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作者 Kamaraju Raghavendra Poonam Sharma Velamuri +1 位作者 Vartika Singhal Roop Kumari 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2026年第4期191-192,共2页
The authors would like to correct an error in Table 1 where the rows corresponding to Reference[8]and Reference[30]were interchanged during alphabetical arrangement of district data,with discrepancies in data for Maha... The authors would like to correct an error in Table 1 where the rows corresponding to Reference[8]and Reference[30]were interchanged during alphabetical arrangement of district data,with discrepancies in data for Maharashtra,Odisha and Uttar Pradesh that have now been rectified.The correct insecticide susceptibility status is provided below.The error does not affect the conclusion of the study.The authors apologize for the error and the inconvenience it might have caused to readers. 展开更多
关键词 scoping review India malaria vectors erratum insecticide susceptibility status alphabetical arrangement insecticide resistance
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Severe malaria-bacterial sepsis co-infection among critically ill children admitted to pediatric emergency departments in Kinshasa 认领 引用
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作者 Mamy-Gloire Monkoti Manzi Celestin Nsibu +1 位作者 Joseph Bodi Philippe Jouvet 《World Journal of Clinical Pediatrics》 2026年第3期271-278,共8页
BACKGROUND Severe malaria remains a major cause of pediatric critical illness and early mortality in sub-Saharan Africa.In pediatric emergency settings,concomitant bacterial sepsis is often under-recognized because of... BACKGROUND Severe malaria remains a major cause of pediatric critical illness and early mortality in sub-Saharan Africa.In pediatric emergency settings,concomitant bacterial sepsis is often under-recognized because of overlapping clinical manifestations,which may delay appropriate antimicrobial therapy and worsen outcomes.Data on severe malaria-bacterial sepsis co-infection among critically ill children in Kinshasa remain limited.AIM To determine the frequency of severe malaria-bacterial sepsis co-infection and identify the associated clinical and biological factors among critically ill children.METHODS This prospective multicenter observational study was conducted from September 2014 to September 2015 in four pediatric emergency departments in Kinshasa,Democratic Republic of Congo.Children aged 6 months to 15 years admitted with life-threatening conditions and confirmed severe malaria were included.Bacterial sepsis was defined by a positive blood culture for a pathogenic organism.Clinical and laboratory variables were compared using Fisher’s exact test and the Mann-Whitney U test.Multivariable logistic regression was performed to identify factors independently associated with co-infection.RESULTS Among 138 children admitted with life-threatening conditions,96(69.6%)had confirmed severe malaria.Severe malaria-bacterial sepsis co-infection was identified in 11 children,representing 11.5%of severe malaria cases.In univariate analysis,respiratory distress,splenomegaly,and hypoglycemia were more frequent among co-infected children.In multivariable analysis,respiratory distress remained independently associated with bacterial coinfection.Early mortality in the emergency department was higher among co-infected children than among those without co-infection.Gram-negative bacteria,predominantly Enterobacteriaceae,accounted for most bloodstream isolates.CONCLUSION Severe malaria-bacterial sepsis co-infection is relatively frequent among critically ill children in Kinshasa and is associated with poorer early outcomes.Early and systematic assessment for sepsis at admission may help improve the initial management of children in pediatric emergency settings. 展开更多
关键词 Severe malaria Bacterial sepsis Co-infection Critically ill children Pediatric emergency care Early mortality Sub-Saharan Africa
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Research on the Mechanisms of Immune Damage Effects and Targeted Regulation Strategies for Malaria Anemia 认领 引用
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作者 ZONG Hongying ZHONG Qinping CHEN Hui 《外文科技期刊数据库（文摘版）医药卫生》 2026年第7期042-046,共5页
Objective To elucidate the key signaling pathways underlying immune damage mechanisms in patients with malaria anemia and evaluate the clinical efficacy of targeted regulatory interventions. Methods Using a retrospect... Objective To elucidate the key signaling pathways underlying immune damage mechanisms in patients with malaria anemia and evaluate the clinical efficacy of targeted regulatory interventions. Methods Using a retrospective analysis design, 68 cases of malaria anemia admitted to our hospital from February 2024 to February 2025 were enrolled as study subjects, divided into a conventional group and a targeted regulation group (each comprising 34 cases) based on intervention approaches. The conventional group received standardized antimalarial therapy and symptomatic support for anemia, while the targeted regulation group additionally underwent immune-targeted modulation therapy in addition to basic treatment. Differences between the two groups were compared in terms of immune cell subpopulation composition, evolution of inflammatory cytokine profiles, erythrocyte immune damage markers, and clinical responses to targeted regulation. Results After intervention, the targeted regulation group exhibited higher proportions of CD4+ T cells, higher hemoglobin concentrations, and better immune-hematopoietic coupling indices compared to the conventional group, whereas the proportion of regulatory T cells and circulating immune complex levels were lower (P <0.05). The targeted regulation group demonstrated superior clinical response rates than the conventional group. Conclusion The targeted regulation approach targeting immune damage mechanisms effectively corrects immune dysfunction in malaria anemia patients, accelerates anemia correction, and provides evidence-based support for precision clinical treatment. 展开更多
关键词 malaria anemia immune damage targeted regulation erythrocyte immunity inflammatory factors
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Biological forms and public health implications of Anopheles stephensi:Addressing the urban malaria challenge 认领 引用
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作者 Gaurav Kumar Himmat Singh Shweta Pasi 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2025年第10期429-430,共2页
Anopheles(An.)stephensi is one of the dominant malaria vectors in India,Bangladesh,Pakistan,Iran,Iraq and some other Asian countries[1].It plays a crucial role in transmitting Plasmodium falciparum and Plasmodium viva... Anopheles(An.)stephensi is one of the dominant malaria vectors in India,Bangladesh,Pakistan,Iran,Iraq and some other Asian countries[1].It plays a crucial role in transmitting Plasmodium falciparum and Plasmodium vivax in India along with its rural counterpart,An.culicifacies.This mosquito species has adapted well to urban and peri-urban environments,making it a significant public health concern in the country.The presence of An.stephensi in urban areas contrasts with other malaria vectors that predominantly inhabit rural regions,thus complicating traditional malaria control strategies.It is well-adapted to human-made environments,breeding in various containers including tanks,cisterns,and barrels used for water storage. 展开更多
关键词 urban malaria plasmodium vivax Plasmodium vivax plasmodium falciparum biological forms malaria vectors Anopheles stephensi public health implications
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Investigating the Role of Antimalarial Treatment and Mosquito Nets in Malaria Transmission and Control through Mathematical Modeling 认领 引用
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作者 Azhar Iqbal Kashif Butt Tariq Ismaeel +4 位作者 Sara Khan Muhammad Imran Waheed Ahmad Ismail Abdulrashid Muhammad Sajid Riaz 《Computer Modeling in Engineering & Sciences》 SCIE EI 2025年第9期3463-3492,共30页
Malaria is a significant global health challenge.This devastating disease continues to affect millions,especially in tropical regions.It is caused by Plasmodium parasites transmitted by female Anopheles mosquitoes.Thi... Malaria is a significant global health challenge.This devastating disease continues to affect millions,especially in tropical regions.It is caused by Plasmodium parasites transmitted by female Anopheles mosquitoes.This study introduces a nonlinear mathematical model for examining the transmission dynamics of malaria,incorporating both human and mosquito populations.We aim to identify the key factors driving the endemic spread of malaria,determine feasible solutions,and provide insights that lead to the development of effective prevention and management strategies.We derive the basic reproductive number employing the next-generation matrix approach and identify the disease-free and endemic equilibrium points.Stability analyses indicate that the disease-free equilibrium is locally and globally stable when the reproductive number is below one,whereas an endemic equilibrium persists when this threshold is exceeded.Sensitivity analysis identifies the most influential mosquito-related parameters,particularly the bite rate and mosquito mortality,in controlling the spread of malaria.Furthermore,we extend our model to include a treatment compartment and three disease-preventive control variables such as antimalaria drug treatments,use of larvicides,and the use of insecticide-treated mosquito nets for optimal control analysis.The results show that optimal use of mosquito nets,use of larvicides for mosquito population control,and treatment can lower the basic reproduction number and control malaria transmission with minimal intervention costs.The analysis of disease control strategies and findings offers valuable information for policymakers in designing cost-effective strategies to combat malaria. 展开更多
关键词 Malaria mathematical modeling optimal control mosquito nets anti-malaria drugs stability and sensitivity analysis
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Epidemiological and clinical features of severe imported Plasmodium falciparum malaria among travelers upon hospital admission 认领 引用
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作者 Emerole Karl Tokmalaev Anatoly +1 位作者 Chentsov Vladimir Mvuania Vellynance 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2025年第10期475-476,共2页
Malaria is considered one of the major causes of travel-related morbidity and mortality,especially among non-immune travelers from non-endemic countries to the endemic regions.According to a multicenter study from the... Malaria is considered one of the major causes of travel-related morbidity and mortality,especially among non-immune travelers from non-endemic countries to the endemic regions.According to a multicenter study from the GeoSentinel surveillance network,malaria was the most frequent cause of fever in 21%of returning travelers,followed by dengue,typhoid fever,chikungunya and rickettsiosis[1].Individuals traveling from regions without malaria transmission to areas where it is endemic face a heightened risk of contracting the disease due to their lack of immunity.Despite the official malaria-free status of the Russian Federation since 2010,annual cases of severe Plasmodium(P.)falciparum malaria continue to be reported[2].This underscores the necessity for heightened clinical vigilance and improved preventive strategies especially in non-endemic settings. 展开更多
关键词 epidemiological features geosentinel surveillance networkmalaria denguetyphoid feverchikungunya multicenter study severe imported plasmodium falciparum malaria clinical features non immune travelers endemic regions
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Proactive detection of imported malaria in malaria-eliminated Sri Lanka 认领 引用
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作者 M K Sampath Indika Kumara Shilanthi Seneviratne 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2025年第6期286-288,共3页
The World Health Organization declared Sri Lanka a malaria eliminated country in 2016[1-3].At present,the country is in the phase of preventing the re-establishment of malaria[4].However,travelers who contract the dis... The World Health Organization declared Sri Lanka a malaria eliminated country in 2016[1-3].At present,the country is in the phase of preventing the re-establishment of malaria[4].However,travelers who contract the disease overseas in malaria endemic countries continue to present a constant risk of re-establishing malaria in Sri Lanka,where malaria-transmitting mosquitos is prevalent.In this context,robust measures are being implemented in the country to prevent re-establishment of malaria and to stop travelers infected with malaria progressing into severe disease and death. 展开更多
关键词 WHO declaration death imported malaria severe disease malaria eliminated Sri Lanka travelers proactive detection
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Evaluating the effects of the free healthcare policy on clinical visits and malaria among children in Burkina Faso:a modeling study of past trends and future forecasts 认领 引用
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作者 AndréLin Ouédraogo Marie-Jeanne Offosse +2 位作者 Julie Zhang Sylvain Toé Pierre Yaméogo 《Global Health Research and Policy》 CSCD 2025年第1期43-54,共12页
Background Access to primary healthcare remains a major challenge in sub-Saharan Africa.In 2016,Burkina Faso introduced the free healthcare policy,eliminating financial barriers by offering free healthcare services fo... Background Access to primary healthcare remains a major challenge in sub-Saharan Africa.In 2016,Burkina Faso introduced the free healthcare policy,eliminating financial barriers by offering free healthcare services for children under five and pregnant women.While previous studies have reported increased healthcare utilization under the policy,its effects on health outcomes remains unassessed.Here,we evaluate the free healthcare policy's effects on three key indicators:frequency of clinical visits,malaria prevalence,and severe malaria.Methods Routine health and demographic data for children under five were collected from health facilities using the government's Electronic Medical Record(EMR)platform.Generalized Linear Mixed Effects Models(GLMM)with a Differences-in-Differences design assessed changes in the three indicators between baseline(2015)and 2018 while Bayesian hierarchical models were used to forecast trends through 2020.Results Analysis of 344,935 clinical visits from 199,664 children across 192 villages showed an increase in healthcare utilization,with clinical visits rising from 1.1 to 2 per child between 2015 and 2018(p<0.001)resulting in a percentage increase of 82%.However,disparities persisted,as children living within 5 km of a health facility accessed more care than those in remote areas(2.2 vs.1.7 visits,p<0.001).Malaria prevalence decreased from 98 to 80%(p<0.001),and severe malaria declined from 6%to 2.2%(p<0.001)during the same period.Bayesian forecasts indicated continued increases in clinical visits(from 2.36 in 2019 to 2.75 in 2020)and further declines in malaria prevalence(to 64%)and severe malaria(to 1.02%)by 2020.Conclusions Our study highlights the transformative effects of the free healthcare policy in improving healthcare access and outcomes for children under five in Burkina Faso.However,inequities in access remain a challenge.Strengthening community health worker programs and expanding community health activities are critical to addressing these gaps.The findings offer valuable insights for policymakers in Burkina Faso and contribute to global efforts to leverage health reforms to improve malaria control and progress toward universal health coverage. 展开更多
关键词 Burkina Faso Free healthcare policy Primary healthcare Children under five Malaria Equity Difference-indifferences Bayesian modeling Gratuité Distance
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Insecticide resistance status of malaria vectors in endemic states of India(2017-2024):A scoping review 认领 引用
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作者 Kamaraju Raghavendra Poonam Sharma Velamuri +1 位作者 Vartika Singhal Roop Kumari 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2025年第8期337-352,I0003-I0013,共16页
Objective:To collate and summarize phenotypic insecticide susceptibility data of Indian malaria vectors from 2017 to 2024,focusing on insecticides used in adult vector control,dichloro diphenyl trichloroethane,malathi... Objective:To collate and summarize phenotypic insecticide susceptibility data of Indian malaria vectors from 2017 to 2024,focusing on insecticides used in adult vector control,dichloro diphenyl trichloroethane,malathion,deltamethrin,alpha-cypermethrin,and permethrin to identify resistance patterns to different classes of insecticides.Methods:The data included information on vector species,location of the study(state/district),insecticide tested,mortality percentage,and susceptibility classification based on the World Health Organization interpretation criteria.Retrospective data were collected from peer-reviewed publications(2017-2024)and up to June 2025.The data were collated for five major malaria vector species,namely Anopheles(An.)culicifacies,An.fluviatilis,An.stephensi,An.baimaii,and An.minimus.Results:Insecticide susceptibility data were available from 86 districts across 16 Indian states for 40615 mosquitoes.The majority of the data was on An.culicifacies(n=28308),followed by An.stephensi(n=5611),An.fluviatilis(n=5967),An.baimaii(n=365),and An.minimus(n=364).Intensity bioassays revealed low to moderate resistance levels in An.culicifacies populations from selected districts in 3 states,Odisha,Madhya Pradesh,and Chhattisgarh against deltamethrin and alpha-cypermethrin.Conclusions:This review highlights spatial and species-level variations in insecticide susceptibility among Indian malaria vectors.The low to moderate intensity suggested that it may not yet be severe enough to cause operational failure with current vector control interventions.Continued monitoring of insecticide resistance,as well as the use of new-generation insecticides and interventions,is suggested to sustain vector control efficacy and manage insecticide resistance in malaria vectors to support India’s malaria elimination. 展开更多
关键词 Malaria vectors Insecticide resistance India
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Association of ABO blood group and Plasmodium falciparum malaria in Dore Bafeno Area,Southern Ethiopia 认领 引用 被引量：10
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作者 Tewodros Zerihun Abraham Degarege Berhanu Erko 《Asian Pacific Journal of Tropical Biomedicine》 CAS 2011年第4期289-294,共6页
Objective:To assess the distribution of ABO blood group and their relationship with Plasmodium falciparum(P.falciparum) malaria among febrile outpatients who sought medical attention at Dore Bafeno Health Center,South... Objective:To assess the distribution of ABO blood group and their relationship with Plasmodium falciparum(P.falciparum) malaria among febrile outpatients who sought medical attention at Dore Bafeno Health Center,Southern Ethiopia.Methods:A total of 269 febrile outpatients who visited Dore Bafeno Health Center,Southern Ethiopia,were examined for malaria and also tested for ABO blood groups in January 2010.The blood specimens were collected by finger pricking,stained with Geimsa,and examined microscopically.Positive cases of the parasitemia were counted.CareStartTM Malaria PflPv Combo was also used to test the blood specimens for malaria.ABO blood groups were determined by agglutination test using ERYCLONE antisera.Data on socio-demographic characteristics and treatment status of the participants were also collected.Chi-square and ANOVA tests were used to assess the difference between frequencies and means,respectively.Results:Out of a total of 269 participants,178(66.2%) febrile patients were found to be infected with Plasmodium parasites,among which 146(54.3%),28(10.4%),and 4(1.5%) belonged to P.falciparum,P.vivax,and mixed infections,respectively.All febrile patients were also tested for ABO blood groups and 51.3%,23.5%,21.9%and 3.3%were found to be blood types of 0,A,B and AB,respectively.Both total malaria infection and P.falciparum infection showed significant association with blood types(P<0.05).The proportion of A or B but not 0 phenotypes was higher(P<0.05) in individuals with P.falciparum as compared with non-infected individuals.The chance of having P.falciparum infection in patients with blood groups A,B and AB was 2.5,2.5 and 3.3times more than individuals showing blood 0 phenotypes,respectively.The mean P.falciparum malaria parasitemia for blood groups A,B,AB,and 0 were 3 744/μ L,1 805/ μ L,5 331/μ L,and1 515/μ L,respectively(P<0.01).Conclusions:The present findings indicate that individuals of blood groups A,B and AB are more susceptible to P.falciparum infection as compared with individuals of blood group O.Nevertheless,further in depth studies are required to clearly establish the role that ABO blood group plays in P.falciparum malaria. 展开更多
关键词 Plasmodium falciparum malaria ABO blood groups Ethiopia Febrile outpatient Parasitemia Association Blood specimen Geimsa CareStartTM Malaria Pf/Pv Combo ERYCLONE antisera Plasmodium parasite Malaria infection Distribution Agglutination test Plasmodium vivax
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Dynamics of resting metabolic rate and innate immune response in malaria-infected Eurasian siskins 认领 引用
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作者 Maria Erokhina Andrey Bushuev +3 位作者 Elena Platonova Vadim Khaitov Alexander Davydov Andrey Mukhin 《Current Zoology》 SCIE CAS CSCD 2025年第6期773-787,共15页
Avian malaria,caused by parasites of the genus Plasmodium,is prevalent among wild bird populations worldwide and can have significant impact on avian health and populations.With the rise in global temperatures due to ... Avian malaria,caused by parasites of the genus Plasmodium,is prevalent among wild bird populations worldwide and can have significant impact on avian health and populations.With the rise in global temperatures due to climate change,concerns have arisen about the spread of southern malaria species,that potentially can affect previously unexposed bird populations.We studied juvenile siskins infected with two distinct malaria parasites:Plasmodium relictum(SGS1 lineage)and P.ashfordi(GRW2 lineage).While the former is common in the Northern Palearctic,the latter is primarily found in Central and Southern Africa.We assessed the impact of these infections on siskins'physiological well-being using resting metabolic rate(RMR)and interleukin-6(IL-6)levels.Changes in RMR reflect the energetic cost of disease,while IL-6 serves as a one of the inflammatory cytokines in the innate immune system's response to infection.Our experimental findings reveal distinct outcomes during the acute phase of SGS1 and GRW2 infections.Infection with SGS1 was marked by reduced RMR and IL-6 levels in siskins.A similar IL-6 pattern was observed in the GRW2 group initially,though it was not sustained.Additionally,GRW2-infected siskins showed distinct RMR dynamics compared to SGS1-infected birds.Our study did not conclusively demonstrate that tropical malaria has more severe effects on siskins.However,similarities with previous studies with SGS1 infected birds and variations in disease progression between the two experimental groups underscore the complexity of host-parasite interactions in avian malaria infections. 展开更多
关键词 Avian malaria experimental infection innate immunity metabolic rate Plasmodium relictum Plasmodium ashfordi
Co-morbidity of malaria and hypertension among adults in Nigeria:patterns,mechanisms,and health barriers 认领 引用
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作者 Ufuomanefe Cleopatra Omoemu Modupe Oluwatemitope Oyedele +2 位作者 Boluwatife Samuel Awe Kamara Alfred Osman Fidelis Ogenetega Ejeheri 《Global Health Journal》 CAS 2025年第3期200-209,共10页
Objective:This review examined the co-morbidity of malaria and hypertension in Nigerian adults,with a focus on epidemiological trends,genetic and environmental risk factors,pathophysiological mechanisms,and systemic h... Objective:This review examined the co-morbidity of malaria and hypertension in Nigerian adults,with a focus on epidemiological trends,genetic and environmental risk factors,pathophysiological mechanisms,and systemic healthcare barriers.Methods:A qualitative synthesis of peer-reviewed literature,national health surveys,and institutional reports published between 2000 and 2025 was conducted using thematic analysis.While centered on Nigeria,the review incorporated comparative insights from global studies on renin angiotensin aldosterone system polymorphisms,co-infection dynamics,and health service inequalities.Results:The findings indicate overlapping risk factors including renin angiotensin aldosterone system gene polymorphisms,urbanization,and poverty.Angiotensin Ⅱ demonstrates dual functions,contributing both to malaria suppression and to hypertension pathogenesis.Clinical challenges include diagnostic overlap,adverse drug interactions,and disparities in service delivery between rural and urban populations.These challenges particularly affect older adults and highlight systemic gaps in access,workforce distribution,and policy alignment.Conclusion:The dual burden of malaria and hypertension in Nigeria requires integrated disease management strategies that address both communicable and non-communicable disease risks.Urgent priorities include multisectoral policy reforms,expanded rural health investments,and the adoption of precision medicine approaches guided by genetic profiling.The implications extend to clinical practice through co-screening and tailored treatment protocols and to public health policy,where integrated frameworks are essential to reducing inequities and improving long-term outcomes. 展开更多
关键词 Co-morbidity Malaria Hypertension Nigeria RAAS polymorphisms Health system barriers
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Integration of sentinel surveillance and climate factors to accelerate malaria elimination in a changing climate of Senegal 认领 引用
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作者 Ibrahima Mamby Keita Mariama Diouf +7 位作者 Medoune Ndiop Boly Diop Khaly Gueye Marianne Kouawo Ousmane Ndiaye Doudou Sene Elhadji Mamadou Ndiaye Marie Khemesse Ngom Ndiaye 《Science in One Health》 2025年第1期233-246,共14页
Background:Senegal is located in a malaria-endemic zone.Malaria is a highly climate-sensitive vector-borne disease,yet its sentinel surveillance shows a weak integration of malaria morbidity data with climatic factors... Background:Senegal is located in a malaria-endemic zone.Malaria is a highly climate-sensitive vector-borne disease,yet its sentinel surveillance shows a weak integration of malaria morbidity data with climatic factors.Therefore,it is useful to analyse the correlation between these factors in Senegal from 2012 to 2019.Methods:An analytical cross-sectional study of malaria incidence rate(MIR)with its climatic factors from 2012 to 2019 was carried out.This was followed by predictive modelling of MIR and its climatic factors from 2020 to 2023.A reconstituted database,incorporating data from National Malaria Control Program(initiated by Ministry of Health)and National Agency for Civil Aviation and Meteorology,enabled a multi-variate analysis through a vector auto regression approach using Microsoft Excel 2010 and R 3.6.1 software.Results:MIR evolved in three phases:initially almost zero from January to May,then gradually increases with an accentuation in August-September,and finally gradually decreases from November to December.However,unlike Podor(0.11‰),MIR heterogeneity was seen in Kedougou(12.55‰)and Bakel(7.34‰).Apart from wind strength and mean temperature which moved in the opposite directions,all other climatic factors evolved in the same dynamics as MIR.MIR followed changes in rainfall and hygrometry with an average lag of(2.5±1.0)months and(1.0±0.5)months,respectively.The causal links between MIR and rainfall showed a decreasing trend in Dakar(P=4.18×10-6),Ziguinchor(P=7.95×10-4),Diourbel(P=1.91×10-3),Kedougou(P=4.03×10-3),and Bakel(P=3.32×10-2).In Bakel,additional associations were observed between MIR and both minimum temperature(P=5.87×10-3)and maximum temperature(P=1.22×10-2)temperatures.Predictive modelling shows an overall downward trend for MIR from 2020 to 2023,with its climatic factors preceding MIR by an average of two months.Conclusion:This study highlights the importance of synchronous,multi-sectoral,and integrated surveillance of malaria alongside climatic factors to more effectively meet pre-elimination requirements in Senegal. 展开更多
关键词 Malaria Incidence Sentinel surveillance Epidemiological surveillance Climatic factor Weather forecast Senegal
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An epidemiological study of malaria parasites among long-tailed macaques(Macaca fascicularis),pig-tailed macaques(Macaca nemestrina)and silver-leaf monkeys(Trachypithecus cristatus)in Sumatra Region,Indonesia 认领 引用
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作者 Sarwo Handayani Rita Marleta Dewi +1 位作者 Lucia Dwi Antika Novaria Sari Dewi Panjaitan 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2025年第1期10-17,共8页
Objective:To ascertain the prevalence and distribution of malaria parasites among the three monkeys species from three provinces in Sumatra Island,Indonesia.Methods:Infections with Plasmodium spp.were determined morph... Objective:To ascertain the prevalence and distribution of malaria parasites among the three monkeys species from three provinces in Sumatra Island,Indonesia.Methods:Infections with Plasmodium spp.were determined morphologically from the blood smears which were stained with Giemsa solution and molecularly through nested polymerase chain reaction(PCR)in DNA samples from 68 primates,which were captured at three locations:Jambi(Bungo district),Bengkulu(Muko-Muko district),and Riau Islands(Lingga district).Results:Out of 68 samples analyzed,46 were positive for various Plasmodium species,including Plasmodium knowlesi,Plasmodium cynamolgi,Plasmodium inui,and Plasmodium coatneyi.Over one-third of the population exhibited multiple infections,with Plasmodium inui being the most predominant strain.Conclusions:The high prevalence of multiple malaria infections in monkeys,coupled with the rising reports of primate malaria cases in human raises questions about the potential for human transmission.These findings emphasize the necessity for ongoing monitoring and endeavors to comprehend and alleviate the risk of zoonotic malaria transmission,particularly in areas experiencing environmental changes. 展开更多
关键词 Malaria parasites Non-human primates Sumatra
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Vaccines Join Flagging Fight Against Malaria 认领 引用 被引量：1
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作者 Esther Wei-Yun Landhuis 《Engineering》 SCIE EI CSCD 2025年第8期5-7,共3页
Most vaccines get injected into muscle,swallowed by mouth,or squirted into the nose.But in a clinical study reported in January 2025 in Nature Medicine[1],researchers in the Netherlands used a less conventional method... Most vaccines get injected into muscle,swallowed by mouth,or squirted into the nose.But in a clinical study reported in January 2025 in Nature Medicine[1],researchers in the Netherlands used a less conventional method to deliver an investigational vaccine:mosquito bites.The mosquitoes carried malaria-causing Plasmod-ium falciparum parasites that had been genetically engineered to trigger a productive immune response without making people sick.Nine of ten study participants who each,in a single session,with-stood 50 bites from this laboratory strain of mosquitoes,success-fully fended off infection when challenged with infective malaria parasites six weeks later. 展开更多
关键词 clinical study investigational vaccine mosquito bitesthe study participants mosquito bites genetic engineering genetically engineered malaria vaccines
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