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Relationship between preoperative modified frailty index,immune inflammation index,and outcomes of colorectal cancer surgery in older patients 认领 引用 被引量:1
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作者 Xing-Si Qi Nai-Ling Liu +1 位作者 Lin Yang Jing Xie 《World Journal of Gastrointestinal Oncology》 SCIE 2026年第2期151-162,共12页
BACKGROUND With the aging of the population,the proportion of older patients with colorectal cancer(CRC)is increasing annually.Preoperative frailty and chronic inflammatory responses may increase the risk of postopera... BACKGROUND With the aging of the population,the proportion of older patients with colorectal cancer(CRC)is increasing annually.Preoperative frailty and chronic inflammatory responses may increase the risk of postoperative complications and affect long-term survival.AIM To assess modified frailty index(mFI)and systemic immune-inflammation index(SII)for predicting postoperative prognosis in older patients with CRC.METHODS We retrospectively analyzed 247 older patients with CRC who underwent radical resection.The SII was calculated as platelet count×neutrophil count/lymphocyte count.Patients were grouped by complication occurrence.Univariate and multivariate analyses were performed for mFI,SII,and postoperative complications.Using receiver operating characteristic curve analysis,the critical SII value for predicting postoperative recurrence was identified,which was then used to divide patients into high/low mFI and high/low SII groups.Using Kaplan-Meier method between-group survival curves were drawn.RESULTS The 30-day complication rate was 12.55%.Multivariate logistic regression analysis identified smoking history[odds ratio(OR)=4.822],prolonged operation time(OR=1.037),and elevated preoperative mFI(OR=9.342)and SII(OR=1.002)as independent risk factors for postoperative complications(P<0.05).On survival analysis,the average recurrence-free survival(RFS)for patients with a low mFI was 47.04 months[95%confidence interval(CI):45.30-48.79],significantly better than the 33.83 months(95%CI:31.31-36.36)for patients with a high mFI(log-rank,P<0.001).The average RFS for patients with a low SII was 47.00 months(95%CI:45.07-48.94),significantly better than the 40.06 months(95%CI:31.37-43.74)for those with a high SII(log-rank,P<0.001).CONCLUSION In older patients with CRC,the preoperative mFI and SII were significantly correlated with postoperative complications and RFS,warranting closer attention to early recurrence detection and intervention. 展开更多
关键词 Colorectal cancer Laparoscopic radical resection Postoperative complications Recurrence-free survival Modified frailty index Systemic immune-inflammation index
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Comparative performance evaluation of asphalt binder modified with high-content pretreated crumb rubber and various additives 认领 引用
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作者 Abul Khair Liyang Wang +4 位作者 Hui Li Yuzhao Han Zhijie Lin Yang Sun Haopeng Zhang 《Journal of Road Engineering》 EI CAS 2026年第1期108-121,共14页
The addition of high-content crumb rubber(HCCR)in asphalt can effectively address waste tire pollution and provide sustainable environmental and economic advantages.However,the practical application of conventional ru... The addition of high-content crumb rubber(HCCR)in asphalt can effectively address waste tire pollution and provide sustainable environmental and economic advantages.However,the practical application of conventional rubberized binders is significantly limited by high viscosity and poor storage stability.To address these issues,researchers have pretreated crumb rubber(CR)with oil,but high-temperature performance remains insufficient.Therefore,this study aimed to optimize the viscosity,storage stability,and rheological properties of high-content crumb rubber-modified asphalt(HCCRMA)by varying the pretreatment levels of CR and incorporating various additives,including styrene-butadiene-styrene(SBS),deoiled asphalt(DA),or recycled low-density polyethylene(RLDPE).In addition,CR was pretreated with waste cooking oil(WCO)at various ratios,pre-swelling temperatures,and times.The results show that DA exhibits excellent storage stability and lower viscosity compared with other modifiers in HCCRMA,and the 4%RLDPE with pretreated HCCR has the greatest high-temperature rutting resistance.The inclusion of RLDPE increases the stiffness and elasticity of the modified asphalt,which results in greater high-temperature performance.Additionally,the fluorescence microscopy(FM)test confirms that SBS exhibits better dispersion than other modifiers and forms a more homogeneous phase separation in the HCCRMA.All in all,this research achieved an optimal balance of storage stability and rheological properties in asphalt modified with pretreated HCCR and 6%SBS,which provides a valuable reference for performance improvement of HCCR-modified binders. 展开更多
关键词 High-content crumb rubber modified asphalt Crumb rubber pretreatment Modified asphalt Storage stability Rheological properties
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Fe/Mn-modified biochar immobilizing Pseudomonas hunanensis SK-4 enhanced simultaneous nitrogen and copper removal:Mechanism and application 认领 引用
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作者 Yuhong Zhang Jiacheng Cai +2 位作者 Jiabao Wang Yueqing Jiang Fengyu Che 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第8期382-390,共9页
To address the challenges posed by the complex composition and high treatment difficulty of composite pollutants,especially copper and nitrogen compounds in water.This study investigated the application of Pseudomonas... To address the challenges posed by the complex composition and high treatment difficulty of composite pollutants,especially copper and nitrogen compounds in water.This study investigated the application of Pseudomonas hunanensis SK-4,which exhibited exceptional resistance to high concentrations of Cu(Ⅱ).Under 100 mg/L Cu(Ⅱ)stress,SK-4 maintained high removal efficiencies of 98.59% for NH4+-N and 83.07%for NO3--N.A novel biocharmicrobial composite(FMABC@SK-4)was prepared by immobilizing SK-4 onto self-synthesized iron-manganese modified biochar.In practical tests,FMABC@SK-4 exhibited excellent simultaneous removal of nitrogen and copper,achieving maximum efficiencies of 99.6% for NH4+-N and 99.43% for Cu(Ⅱ).The results indicated that FMABC@SK-4 removes Cu2+mainly through physical adsorption and surface complexation,whereas nitrogen removal is driven by heterotrophic nitrification-aerobic denitrification and ammonia assimilation processes.These findings underscored the potential of FMABC@SK-4 for treating complex wastewater containing both heavy metals and nitrogen,providing an efficient and mechanism-based strategy for enhanced pollutant removal. 展开更多
关键词 Water treatment Heavy metals Modified biochar Biodegradation Composite pollutants
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Global trends in the commercialization of genetically modified crops in 2024 认领 引用
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作者 Haohui Li Xingru Cheng +5 位作者 Liqiang Wang Pei Xie Haiwen Zhang Yadong Yang Tao Liu Youhua Wang 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2026年第4期1307-1315,共9页
The ongoing commercialization of genetically modified(GM)crops continues to enhance global grain yields,improve crop quality,and reduce pesticide usage.These technological advancements have effectively propelled agric... The ongoing commercialization of genetically modified(GM)crops continues to enhance global grain yields,improve crop quality,and reduce pesticide usage.These technological advancements have effectively propelled agricultural production systems toward sustainable transformation.Specifically,GM crops address core challenges such as pest infestations,weed proliferation,and arable land constraints,emerging as a pivotal new productive force in agriculture.This study systematically examines the global spatial distribution patterns of GM crops in 2024 and provides an indepth analysis of the driving forces and evolving regional trends,offering critical informational support and strategic guidance for innovation in agricultural science and technology.In 2024,the global GM crop cultivation area reached 209.8 million hectares,a 1.7%year-on-year increase.GM Glycine max(soybean)and Zea mays(maize)dominated the landscape,accounting for 50.0 and 32.5%of the total area,respectively.Among them,maize with stacked traits of insect resistance and herbicide tolerance accounts for 92.5%of GM maize.The share of cultivation in developing countries expanded substantially,with Brazil and Vietnam emerging as regional growth drivers.Policy support and the diffusion of advanced technologies were identified as core driving forces.Concurrently,applications of gene-editing technology accelerated,and several countries approved novel traits such as drought tolerance and disease resistance,marking substantial progress in the commercialization of next-generation GM crops.This research provides multidimensional insights and strategic guidance to support global agricultural biotechnology development,promoting the transition of biotechnology breeding into the‘4.0 era'. 展开更多
关键词 genetically modified crops commercialization global agriculture cultivation area biotechnology
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A dual-component strategy for ambiently-cured high-toughness red mud based geopolymer:Modified nano-TiO2 and sodium polyacrylate 认领 引用
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作者 CHEN Jing BAI Bing +2 位作者 NIE Qing-ke BAI Fan ZHANG Hai-qing 《Journal of Central South University》 SCIE EI CAS CSCD 2026年第4期1553-1567,共15页
In response to the growing demand for sustainable construction materials,this study overcomes the inherent brittleness and poor fracture resistance of red mud-based geopolymer(RBG)through the strategic combination of ... In response to the growing demand for sustainable construction materials,this study overcomes the inherent brittleness and poor fracture resistance of red mud-based geopolymer(RBG)through the strategic combination of surface-modified nano-TiO 2(NT)and sodium polyacrylate(SPA).The NT was functionalized with silane coupling agent to improve dispersibility and interfacial bonding,while SPA was added to enhance fracture toughness.Under the condition of ambient curing,the optimum mixture containing 3 wt%(glycidoxypropyltriethoxysilane)-modified NT(GNT)and 0.5 wt%SPA achieved a 28 d compressive strength of 43.40 MPa and a flexural strength of 8.16 MPa.The performance index meets the Portland cement(PC 42.5)standards.Microstructural analyses(XRD,FT-IR and SEM EDS)revealed that the formation of geopolymer gel was increased,the crystallinity was reduced,and the degree of polymerization was improved,which confirmed the effectiveness of this method in producing high-toughness and environmentally friendly geopolymer. 展开更多
关键词 red mud geopolymer modified nano-TiO2 sodium polyacrylate synergistic toughening
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Effects of minimally coupled modified gravity on the gravitational collapse of compact matter structures 认领 引用
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作者 M Yousaf A Rehman +2 位作者 M M M Nasir S Hanif H Asad 《Communications in Theoretical Physics》 SCIE CAS CSCD 2026年第2期134-162,共29页
Our analysis is particularly motivated by its relevance to understanding compact object instabilities,gravitational collapse thresholds,and the formation of dense structures under the influence of modified gravity the... Our analysis is particularly motivated by its relevance to understanding compact object instabilities,gravitational collapse thresholds,and the formation of dense structures under the influence of modified gravity theories.The interplay of anisotropic pressures,perturbative dynamics,and modified gravity contributions offers insight into both the stable configuration of dense fluids and the mechanisms leading to dynamical instability.Such considerations directly contribute to the aims of high energy density profiles,particularly in modeling physical systems where extreme pressure,curvature,and matter interactions co-exist.We consider an axially symmetric,dense structure with anisotropic matter content and employ a specific equation of state(EoS)to examine the interplay between static and dynamic quantities via the adiabatic index.To address the complex dynamics of the collapse process,a perturbative scheme is utilized under Newtonian and post-Newtonian approximations,enabling a detailed examination of the stability and structural evolution of the system under the influence of the considered minimally coupled gravity.Our results demonstrate that hydrostatic equilibrium is maintained when effective pressure,gravitational,and anti-gravitational forces are balanced,while deviations from this balance initiate dynamical instability.Graphical representations of stable and unstable regimes are presented,revealing how the choice of gravity functions significantly affects the outcome.This work provides insight into the behavior of dense,self-gravitating configurations under modified gravity,offering broader implications for the modeling of compact astrophysical objects and contributing to the understanding of gravitational collapse in energy density regimes. 展开更多
关键词 modified theory gravitational collapse dynamical behavior Newtonian post-Newtonian
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Therapeutic effect and anti-inflammatory mechanism of modified Shoutai pills(改良寿胎丸)against lipopolysaccharide-induced miscarriage in mice 认领 引用
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作者 LI Junwei LIU Xinyue +10 位作者 MOU Xuan XIE Hongliang GAO Yating ZHANG Aolin HE Tao YEUNG Tszching TANG Chao WU Xiaoke FAN Xiaohui WANG Chichiu LI Lu 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2026年第1期22-33,共12页
OBJECTIVE:To elucidate the anti-inflammatory mechanisms of modified Shoutai pills(改良寿胎丸,MSTP)in miscarriages,we performed transcriptome sequencing on the decidua and placental tissues of pregnancy mice.METHODS:Th... OBJECTIVE:To elucidate the anti-inflammatory mechanisms of modified Shoutai pills(改良寿胎丸,MSTP)in miscarriages,we performed transcriptome sequencing on the decidua and placental tissues of pregnancy mice.METHODS:The therapeutic effects and antiinflammatory mechanisms of MSTP were studied in mice with lipopolysaccharide(LPS)-induced miscarriage.First,the effects of MSTP on pregnancy outcomes and the maternal-fetal interface,in LPS-induced miscarriage mice were examined.RNA sequencing was used to further investigate gene expression changes in LPS-induced miscarriage mice and to assess the effects of MSTP intervention.Finally,the expression levels of inflammation-related genes in the decidua and placental tissues were determined using quantitative real-time polymerase chain reaction(q RT-PCR).RESULTS:A high dose of MSTP significantly decreased the resorption rate(P<0.05)and reduced apoptosis of the decidua and placental tissues in mice.Gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses showed that inflammatory and immune-related signals were enriched.q RT-PCR results confirmed that in decidual and placental tissues,MSTP reduced the gene expression levels of toll-like receptor 4(TLR4),nuclear factor kappa-B(NF-κB),c-Jun N-terminal kinase 1,p38,and tumor necrosis factor-α.CONCLUSIONS:In this study,we demonstrated that MSTP effectively prevented embryo loss with an antiinflammatory mechanism through downregulation of the TLR4-NF-κB/MAPK signaling pathway,in LPS-induced miscarriage mice model.To our knowledge,this is the first study to reveal the therapeutic mechanism of MSTP in LPS-induced miscarriage in mice. 展开更多
关键词 abortion,spontaneous NF-kappa B toll-like receptor 4 transcriptomics modified Shoutai pills
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Integrated Transcriptomic and Metabolomic Analysis Reveals the Adaptive Mechanism of Penicillium digitatum under Modified Atmosphere Packaging Based on Amino Acid Metabolism 认领 引用
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作者 HAO Shanshan WANG Zhengli +3 位作者 XU Huihui JI Nana GUO Yanyin Abbas AQLEEM 《食品科学》 EI CAS CSCD 北大核心 2026年第6期129-144,共16页
This study employed integrated multi-omics approaches to elucidate,from the perspective of amino acid metabolism,the adaptive mechanism of Penicillium digitatum under modified atmosphere packaging(MAP)conditions.Compa... This study employed integrated multi-omics approaches to elucidate,from the perspective of amino acid metabolism,the adaptive mechanism of Penicillium digitatum under modified atmosphere packaging(MAP)conditions.Comparative analysis of natural air(Air),controlled atmosphere(CA),and MAP treatments revealed that MAP upregulated the expression of the hercynylcysteine S-oxide synthase(HCSOS),aldehyde dehydrogenase(ALDH),and monoamine oxidase(MAO)genes,thereby enhancing histidine-derived ergothioneine and methionine levels,and subsequently boosting glutathione-mediated redox homeostasis.Meanwhile,MAP induced the expression of the dihydroxyacid dehydratase(DHAD),saccharopine dehydrogenase(SDH),and arginosuccinate lyase(ASL)genes,redirecting valine,lysine,and arginine into the tricarboxylic acid(TCA)cycle to fuel ATP production.MAP also enhanced ASL-mediated arginine degradation and urea cycle activity,reducing arginine accumulation when compared to CA treatment.In contrast,while MAP induced upregulated expression of the pyrroline-5-carboxylate dehydrogenase(P5CDH)and D-amino acid oxidase(DAAO)genes,CA treatment promoted proline accumulation,reflecting stress-specific metabolic flexibility.Collectively,these findings demonstrate that MAP triggers transcriptional reprogramming of amino acid metabolism to coordinate oxidative defense,energy generation,and osmotic balance.By modulating these metabolic pathways and regulatory genes under MAP conditions,fungal adaptability can be disrupted.Hence,this study provides a promising strategy for suppressing green mold development,extending the postharvest shelf life,and improving the quality of fruits and vegetables. 展开更多
关键词 amino acid metabolism multi-omics Penicillium digitatum modified atmosphere packaging postharvest pathology
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Modified wheat bran insoluble dietary fiber ameliorates lipid metabolism in high fat diet rats 认领 引用
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作者 Aimei Liao Jie Zhang +8 位作者 Zhirui Ding Long Pan Yinchen Hou Jianzheng Li Quanping Liu Jihong Huang Ting Xiao Ming Hui Peng Li 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第7期3296-3304,共9页
Wheat bran was synergistically fermented using a mixture of probiotic strains that is Lactobacillus plantarum and Lactobacillus acidophilus in a 1:1 ration under the same condition.Insoluble dietary fiber(IDF)was isol... Wheat bran was synergistically fermented using a mixture of probiotic strains that is Lactobacillus plantarum and Lactobacillus acidophilus in a 1:1 ration under the same condition.Insoluble dietary fiber(IDF)was isolated from wheat bran with or without fermentation modification.The changes of physicochemical and functional properties of IDF were measured.The effects of modified wheat bran IDF(C-IDF)on obesity and lipid metabolism in high-fat diet(HFD)rats were also investigated.Results indicated that loose density(LD),tapped bulk density(TBD)of the C-IDF were significantly decreased by 10.81%and 4.03%,respectively,compared to those of U-IDF.While the binding abilities of water and oil,the adsorption capacities of nitrite ion,as well as the cation exchange competence of C-IDF were significantly enhanced(P<0.05)by 13.43%,10.19%,and 14.39%,respectively.Compared to the rats in HFD group,the body weight,total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),malondialdehyde(MDA),activities of alanine aminotransferase(ALT)and aspartate aminotransferase(AST)of rats treated with C-IDF were significantly decreased(P<0.05),while fecal fat content and glutathione(GSH)level of rats in C-IDF group were significantly increased(P<0.05).The high-density lipoprotein cholesterol(HDL-C),and activity of superoxide dismutase(SOD)of rats administrated with C-IDF revealed an upward trend.The mRNA expression levels of hepatic lipid metabolism-related genes(Fasn and Ppara)were significantly up-regulated(P<0.05).The mRNA expression levels of inflammation related genes(MyD88 and NF-κB)were significantly down-regulated(P<0.05).The protective effects of C-IDF on the liver and colon were confirmed by simultaneous histological observation.The potential mechanism of C-IDF to prevent from HFD induced obesity and lipid metabolism disorder was carried out through interfering with Fasn/Ppara and TLR4/MyD88/NF-κB signaling pathway.Overall,synergistic probiotic fermentation altered the physicochemical and functional properties of wheat bran IDF.The modified IDF suggested potential hyperlipidemic benefits and promising application in healthy food production. 展开更多
关键词 Insoluble dietary fiber Modifi cation Physicochemical properties Obesity Lipid metabolism
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Crosslinking Behavior and Curing Properties of Environmentally Friendly Polyurethane Modified Asphalt Prepared by In-situ Polymerization 认领 引用
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作者 GONG XING SUN Mingzhi +2 位作者 WAN PEI LIU Quantao WU Shaopeng 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS CSCD 2026年第4期1134-1144,共11页
This study investigated the crosslinking behavior and curing properties of environmentally friendly polyurethane(PU)modified asphalt(PUMA)prepared by in-situ polymerization.The research aimed to clarify the chemical r... This study investigated the crosslinking behavior and curing properties of environmentally friendly polyurethane(PU)modified asphalt(PUMA)prepared by in-situ polymerization.The research aimed to clarify the chemical reaction sites and sequence between the PU prepolymer(PUP)and asphalt components,and to evaluate the microstructural and performance evolution of PUMA during curing.Density functional theory(DFT)calculations were employed to predict reactive sites based on electrostatic potential and frontier molecular orbitals,and to compute Gibbs free energy and transition state energy barriers.The experimental results indicate that phenolic hydroxyl and pyridinic nitrogen in asphaltene molecules and phenolic hydroxyl in resin molecules are the primary sites for reaction with PUP.PUP reacts spontaneously with chain extender(BDO),water,asphaltene,and resin at room temperature,with the reaction following the order:BDO>H2O>asphaltene-1>asphaltene-2>resin.Microstructural analysis by atomic force microscopy reveals that PU acts as a bridge connecting asphaltene and resin,forming an integrated network that became more perfect with prolonged curing time.Fourier transform infrared spectroscopy of SARA fractions confirms the formation of amide bonds between PUP and asphalt components.The high-temperature performance of PUMA improves with curing time,while the low-temperature performance slightly decreases but still meets specification requirements after 180 days of curing.The findings can provide a fundamental basis for the design and preparation of high-performance PUMA. 展开更多
关键词 PU modified asphalt density function theory crosslinking behavior curing property insitu polymerization
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Evaluation of safety and immunogenicity of a genetically modified rabies virus for use as an oral vaccine in several non-target species 认领 引用
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作者 Xijun Wang Hong Huo +8 位作者 Lei Shuai Jinying Ge Liyan Peng Jinming Wang Shuang Xiao Weiye Chen Zhiyuan Wen Jinliang Wang Zhigao Bu 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2026年第2期814-819,共6页
Oral immunization is an alternative or supplementary approach that can significantly improve dog vaccination coverage,especially for free-roaming dogs.Safe and effective oral rabies vaccines for dogs are still being s... Oral immunization is an alternative or supplementary approach that can significantly improve dog vaccination coverage,especially for free-roaming dogs.Safe and effective oral rabies vaccines for dogs are still being sought.In our previous studies,we generated a genetically modified rabies virus(RABV) ERA strain,rERAG333E,containing a mutation from arginine(Arg,R) to glutamic acid(Glu,E) at residue 333 of the G protein(G333E).Our previous results demonstrated that rERAG333E was safe for adult mice and dogs,and oral vaccination with rERAG333E induced a strong and long-lasting protective immune response in dogs.Here,we further investigated the safety and immunogenicity of rERAG333E in nontarget species,including suckling mice,rhesus monkeys,foxes,raccoon dogs,piglets,goats,and sheep.Suckling mice studies demonstrated that the G333E mutation significantly reduced the virulence of the ERA strain.All of the suckling mice aged 10 days and above survived and showed no apparent signs of disease after intracerebral inoculation with rERAG333E.Animal studies demonstrated that rERAG333E was safe in rhesus monkeys,foxes,raccoon dogs,piglets,goats,and sheep.None of those animals inoculated orally with 10 times the intended field dose of rERAG333E showed abnormal clinical signs before and after the booster immunization with Rabvac 3,an inactivated rabies vaccine.Meanwhile,oral inoculation with rERAG333E induced strong neutralizing antibody(NA) responses to RABV in rhesus monkeys,foxes,raccoon dogs,and piglets.These results demonstrated that rERAG333E has the potential to serve as a safe oral rabies vaccine for dogs. 展开更多
关键词 rabies genetically modified rabies virus oral vaccine
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Modeling of bolted beam utilizing modified joint element and identification of contact parameters at the joint 认领 引用
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作者 Xiang Li Zhousuo Zhang +1 位作者 Zhuofan Zhou Dian Chen 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2026年第2期374-382,共9页
Research on the modeling of bolted connection structures primarily centers on the characterization of the connection interface.Accurate equivalent modeling of the connection interface is crucial for the effective mode... Research on the modeling of bolted connection structures primarily centers on the characterization of the connection interface.Accurate equivalent modeling of the connection interface is crucial for the effective modeling of bolted connection structures.This article considers the misalignment between the bolt plane and the beam plane,and establishes a modified joint element representing the bolted connection by using the seriesstiffness method.The contact stiffness in this modified joint element are identified using a genetic algorithm with an “emperor selection” strategy.The bolted connection beam model is achieved by refining the Euler-Bernoulli beam model through the incorporation of a modified joint element.The maximum error between the model calculation results and experimental results for each order of natural frequency is 2.39%.This demonstrates the feasibility of accurately characterizing the bolted connection beam through the utilization of the modified joint element for equivalent modeling.This research proposes a modeling method for bolted connection beams that accounts for the misalignment between the bolt plane and the beam plane,significantly enhancing modeling accuracy. 展开更多
关键词 Bolted joints Modified joint element Genetic algorithm Parameter identification
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Removal of Ca and Fe from modified steelmaking slag leachate by wet chemical precipitation 认领 引用
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作者 You-Dong Fang Fu-Jun Fang +3 位作者 Mu-Yi Cheng Ning-Ning Lv Chang Su Hai-Chuan Wang 《Journal of Iron and Steel Research International》 SCIE EI CSCD 2026年第3期170-182,共13页
Acid is commonly used to separate phosphorus-containing solid solutions from steelmaking slag.However,the acid leaching solution obtained from this process cannot be directly utilized and thus requires purification.Th... Acid is commonly used to separate phosphorus-containing solid solutions from steelmaking slag.However,the acid leaching solution obtained from this process cannot be directly utilized and thus requires purification.The effect of different conditions on the calcium and iron removal characteristics of modified steelmaking slag leaching solution was investigated.Additionally,the removal mechanism was analyzed by thermodynamic calculations.The results indicated that the addition of soybean straw ash in steelmaking slag modification enabled K2O to enter the phosphorus-containing solid solution,promoting phosphorus enrichment.Valuable elements such as phosphorus and potassium were more easily dissolved in the mixed acid.The oxalic acid concentration had a significant effect on the calcium removal rate,whereas the effects of temperature,stirring rate,and time on the calcium removal rate were minor.The main component of the calcium removal precipitate was CaC2O4·H2O,with a removal rate up to 94.48%.During the iron removal process,when the pH value of the solution was low,Fe3+mainly reacted to form the iron hydroxide precipitate for removal.Increasing the pH value of the solution would cause Fe3+to combine with H2PO4-,forming FePO4·2H2O precipitate,leading to a reduction in the phosphorus content of the leaching solution. 展开更多
关键词 Modified steelmaking slag Phosphorus recovery Leaching solution Calcium removal Iron removal Oxidative precipitation
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Study on the effect of modified magnetic nanoparticles Co3O4@HPAM monomer ratio on viscosity reduction of thick oil emulsification 认领 引用
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作者 Nana Sun Hongmei Dong +1 位作者 Jian Liu Jianbo Hu 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2026年第4期183-195,共13页
To improve the dispersibility and emulsification performance of magnetic nanoparticles,this study first synthesized three modified magnetic nanoparticles(Co3O4@HPAM)with different monomer ratios and characterize... To improve the dispersibility and emulsification performance of magnetic nanoparticles,this study first synthesized three modified magnetic nanoparticles(Co3O4@HPAM)with different monomer ratios and characterized their physical properties.On this basis,the effects of the modified magnetic nanoparticles with different monomer ratios on the emulsification and viscosity reduction of thick oil were investigated by stability and rheology;finally,the emulsification and viscosity reduction mechanism was revealed by combining the zeta potential,surface tension,contact angle,and oil droplet distribution.The results showed that Co3O4@HPAM with three different monomer ratios was successfully synthesized and exhibited good dispersibility.With the increase of monomer ratio,the emulsion water fraction decreased first and then increased,and the viscosity reduction decreased first and then increased.At a mass fraction of 0.04%,the sample with a 15%monomer ratio exhibited the lowest water separation rate(6.45%at 4 h)and the highest viscosity reduction rate(97.93%).This phenomenon occurs because,at a15%monomer ratio,the modified magnetic nanoparticles have a higher negative charge,a larger contact angle,lower oil-water interfacial tension,and smaller,more uniformly distributed oil droplets.This study offers a theoretical foundation for using magnetic nanoparticles in heavy oil emulsification to reduce viscosity. 展开更多
关键词 Modified magnetic nanoparticles Physical characterization Stability Rheology Zeta potential Contact angle Interfacial tension Oil droplet distribution
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Modified Hu-Lian-Bi-Guan decoction for wound healing in complex anal fistula:A randomized controlled trial 认领 引用
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作者 Han-Wen Yang Ting-Ting Li +8 位作者 Xin-Bo Song Li-Xia Lai Qiang Yu Huang-Fu Ma Yue Wang Xue-Cheng Zhang Xiao-Yu Chen Shu-Xin Zhang Jia-Nan Li 《World Journal of Gastroenterology》 SCIE CAS 2026年第11期44-54,共11页
BACKGROUND Complex anal fistulas(AFs)frequently require extensive surgical excision,leading to large,slow-healing wounds that significantly affect the quality of life.Therefore,the optimization of the postoperative wo... BACKGROUND Complex anal fistulas(AFs)frequently require extensive surgical excision,leading to large,slow-healing wounds that significantly affect the quality of life.Therefore,the optimization of the postoperative wound microenvironment to accelerate healing is an urgent clinical priority.AIM To evaluate the clinical efficacy and mechanism of modified Hu-Lian-Bi-Guan decoction(mHLBGD)in promoting postoperative wound healing for complex AF.METHODS In this randomized controlled trial,56 adults with complex AF were randomly assigned(1:1)to receive standard surgical care(control group,n=28)or standard care with oral mHLBGD(treatment group,n=28)for 14 days.Clinical outcomes included wound healing rate,Visual Analog Scale,wound exudate,wound edema,and Wexner incontinence scores,and complete healing time.Mechanistically,paired tissue samples were analyzed to assess the expression of inflammatory cytokines,TGF-β/Smad pathway components,and epithelial-mesenchymal transition(EMT)markers.RESULTS Baseline characteristics were comparable between the two groups.The mHLBGD group demonstrated a significantly shorter median time to complete wound healing than the control group(32 days vs 50 days;P<0.001),and achieved higher wound healing rates at all postoperative follow-ups.Postoperative pain,wound exudate,and edema scores were significantly lower in the mHLBGD group(P<0.001)with no adverse effects on continence.Per histological analysis,mHLBGD treatment significantly diminished inflammatory infiltration,edema,and hemorrhage while enhancing granulation tissue maturation and promoting reparative epithelial proliferation.At the molecular level,mHLBGD treatment significantly downregulated the expression of IL-1β,IL-6,TGF-β,Smad2,N-cadherin,and vimentin,and upregulated E-cadherin by day 14 compared to controls.CONCLUSION Oral mHLBGD effectively accelerates postoperative wound healing in complex AF by reducing local inflammation and TGF-β/Smad signaling pathway regulation to inhibit pathological EMT,suggesting its potential for improving recovery post-surgery. 展开更多
关键词 Modified Hu-Lian-Bi-Guan decoction Complex anal fistula TGF-β/Smad signaling pathway Epithelial-mesenchymal transition Inflammatory factors
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Modified splenic arteriovenous fistula creation at tail of transplanted pancreas prevents thrombosis in simultaneous pancreas-kidney transplantation 认领 引用
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作者 Mei-Si Li Jian-Hui Dong +8 位作者 Jun-Jie Sun De-Cheng Lu Ji-Qiu Wen Ning Wen Liu-Gen Lan Ji-Hua Wu Hai-Bin Li Zhi-Ying Lei Xu-Yong Sun 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS CSCD 2026年第2期229-233,共5页
To the Editor:Simultaneous pancreas-kidney transplantation(SPKT)is currently the most effective treatment for diabetes complicated by end-stage renal disease.SPKT improves quality of life,significantly slows the progr... To the Editor:Simultaneous pancreas-kidney transplantation(SPKT)is currently the most effective treatment for diabetes complicated by end-stage renal disease.SPKT improves quality of life,significantly slows the progression of diabetic retinopathy,prevents or even reverses diabetic neuropathy,and has particularly notable long-term benefits for cardiovascular diseases[1].To date,over 40000 pancreatic transplants have been reported worldwide[2]. 展开更多
关键词 simultaneous pancreas kidney transplantation modified splenic arteriovenous fistula tail pancreas thrombosis transplanted pancreas pancreatic transplantation diabetic retinopathyprevents diabetic neuropathyand
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Freeze-thaw damage continuous constitutive of modified asphalt mixture based on the MMF model 认领 引用
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作者 Shuai Mao ShaoLong Jie +4 位作者 ZuRun Yue TianFei Hu CaoLin Qing ZhongAng Zhai ChenPeng Miao 《Research in Cold and Arid Regions》 CAS CSCD 2026年第3期197-207,共11页
A modified asphalt mixture was prepared using polystyrene-butadiene-styrene block copolymer(SBS)and waste tire rubber powder(WTRP),with the asphalt mixture ratio optimized based on the particle accumulation theory and... A modified asphalt mixture was prepared using polystyrene-butadiene-styrene block copolymer(SBS)and waste tire rubber powder(WTRP),with the asphalt mixture ratio optimized based on the particle accumulation theory and the particle interference effect.Considering the impact of freeze-thaw cycles(FTC),the evolution of the stress-strain relationship about the material was analyzed from various perspectives,including strength dete-rioration and freeze-thaw damage,using the splitting strength tests.A unified calculation model for strength deterioration was developed using a single logarithmic coordinate transformation,effectively capturing the strength degradation behavior of asphalt mixtures under FTC while minimizing test errors in coarse-grained mixtures.The results showed that:(1)After 30 freeze-thaw cycles,the matrix asphalt mixture exhibited the highest strength loss rate of 45.08%.(2)The SBS/WTRP-modified asphalt mixture with AC-16C grading showed the lowest freeze-thaw strength degradation rate,reduced to 47.59%of the pre-modification rate.(3)A continuous damage constitutive relationship for asphalt mixtures considering FTC was established based on the Morgan-Mers-Flodin(MMF)model and the strain equivalence principle.Using data from the first 20 freeze-thaw strength deterioration tests,the model could predict strength deterioration curves for 25 and 30 FTC.This study aims to investigate the SBS/WTRP-modified asphalt mixtures and establish a continuous damage constitutive model based on the MMF model to predict long-term performance under FTC. 展开更多
关键词 Freeze-thaw damage Continuous constitutive Morgan–Mers–Flodin Modified asphalt mixture Waste tire rubber powder
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Influencing factors of reserve time and the rheological properties of thermosetting polyurethane-modified asphalt 认领 引用
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作者 LI Hui REN Jiaxing +2 位作者 WANG Hanbing ZUO Xin DENG Hanyu 《Journal of Southeast University(English Edition)》 EI CAS 2026年第2期147-155,共9页
Thermosetting polyurethane‑modified asphalt(PUMA)undergoes an irreversible curing reaction,which means any improper handling during construction cannot be corrected.This study investigates the effects of hard segment ... Thermosetting polyurethane‑modified asphalt(PUMA)undergoes an irreversible curing reaction,which means any improper handling during construction cannot be corrected.This study investigates the effects of hard segment content,isocyanate index,polyurethane(PU)content,and temperature on the viscosity of PUMA and proposes a method for regulating its reserve time.Based on viscosity‑temperature profiles,a viscosity growth model was established to predict the evolution of PUMA viscosity with temperature and time.The results indicate that temperature exerts the most pronounced effect on the reserve time of thermosetting PUMA.Moreover,the developed viscosity growth model under different temperatures enables the prediction of PUMA reserve time.As PU content increases,the microstructure of PUMA evolves from a dispersed to a continuous phase.When the PU content exceeds 30%,a continuous crosslinked network forms,imparting excellent thermal resistance and elastic recovery at high temperatures.Furthermore,high PU content enhances the low‑temperature flexibility of PUMA.These findings provide valuable insights for optimizing the application of PUMA materials in pavement engineering. 展开更多
关键词 road engineering polyurethan‑modified asphalt
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Revolutionizing buckling mechanics of agglomerated nanocomposite-honeycomb sandwich annular plates through a refined zigzag theory-based thermoelastic model on modified Winkler-Pasternak foundation 认领 引用
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作者 Z.KHODDAMI MARAGHI E.ARSHID P.RAHIMKHANI 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2026年第5期1105-1130,共26页
Lightweight sandwich annular plates with honeycomb cores(HCCs) and carbon-nanotube-reinforced face sheets have been widely used in aerospace and energy structures where the high stiffness-to-weight ratio and the buckl... Lightweight sandwich annular plates with honeycomb cores(HCCs) and carbon-nanotube-reinforced face sheets have been widely used in aerospace and energy structures where the high stiffness-to-weight ratio and the buckling reliability are required. In this paper, an integrated thermo-mechanical buckling model is presented for such plates resting on a radially graded modified Winkler-Pasternak(MWP) elastic foundation. The interlaminar shear deformation and the layerwise displacement continuity are accurately represented with the refined zigzag theory(RZT), while the carbon nanotube(CNT) agglomeration effects are considered with the Mori-Tanaka homogenization scheme. The governing equations are solved with the generalized differential quadrature method(GDQM). The results indicate that the CNT dispersion quality is more decisive than the CNT volume fraction, and the severe agglomeration reduces the critical buckling load by approximate 50%. A proper honeycomb design, particularly with a cell angle of approximate 30°, a wall thickness ratio within the range of 0.1 to 0.15, and a compact cell configuration, markedly enhances the structural stability. The radially graded foundation stiffness interaction increases the buckling capacity by 6%–15%, whereas temperatures of 300 K–400 K slightly reduce the capacity. 展开更多
关键词 honeycomb core(HCC) carbon nanotube(CNT)-reinforced nanocomposite refined zigzag theory(RZT) modified Winkler-Pasternak(MWP)foundation buckling analysis
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Surface oxygen vacancy trigger peroxymonosulfate activation with cobalt modified montmorillonite for ofloxacin degradation:The synergistic effect of 1O2and Co(Ⅳ)=O 认领 引用
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作者 Xiao-qiang Cao Xingyao Liu +8 位作者 Yaqi Wang Haining Wang Bo Wei Yanan Shang Yizhen Zhang Yujiao Kan Yang Zhang Xing Xu Longlong Zhang 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第6期816-824,共9页
Oxygen vacancy engineering in heterogeneous catalysts has attracted considerable interest for peroxymonosulfate(PMS)activation.In this study,nano-Co3O4-encapsulated montmorillonite catalysts with tunable oxygen ... Oxygen vacancy engineering in heterogeneous catalysts has attracted considerable interest for peroxymonosulfate(PMS)activation.In this study,nano-Co3O4-encapsulated montmorillonite catalysts with tunable oxygen vacancy(OV)concentrations(denoted as Co3O4−Mt-xOV,x=2,4,6)were synthesized for enhanced PMS activation.These OV defects not only modulate the electronic structure of Co3O4but also strengthen PMS and contaminant adsorption.The optimized Co3O4−Mt-xOV/PMS system exhibited exceptional ofloxacin(OFL)degradation efficiency,achieving 2.74–3.43-fold enhancement over OV-free Co3O4−Mt.Density functional theory calculations and experimental studies revealed that the performance improvement stemmed from OV formation,which synergistically enhanced redox pair cycling,strengthened PMS adsorption,and promoted active species generation during electron transfer.Further studies demonstrated that OV sites selectively drive PMS decomposition to generate high-valent cobalt-oxo species(Co(Ⅳ)=O)and singlet oxygen(1O2)as the dominant reactive species for OFL oxidation.The in-depth investigation into the catalytic mechanism revealed that the Co(Ⅳ)=O species facilitated O2generation in surpassing the reaction energy barrier,which subsequently converted to1O2.This non-radical pathway endowed the system with robust anti-interference capability against complex water matrices.The critical role of OV in PMS activation was mechanistically confirmed through experimental and theoretical analyses.Furthermore,Co3O4−Mt-4OV demonstrated outstanding chemical stability and recyclability,highlighting its practical potential.This work provides fundamental insights into vacancy defect engineering for advanced PMS activation and offers strategic guidance for designing high-performance catalysts. 展开更多
关键词 Peroxymonosulfate(PMS) Co3O4 Modified montmorillonite Oxygen vacancy Ofloxacin Singlet oxygen(1O2) High-valent cobalt-oxo species(Co(Ⅳ)=0)
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