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Drifting Modulation Instability:Periodization of General Breathers,Asymmetric Sideband Modulation,and IST Spectral Portrait 认领 引用
1
作者 Ming-Hao Ma Xiaotian Xu +1 位作者 Chong Liu Wen-Li Yang 《Chinese Physics Letters》 SCIE EI CAS CSCD 2026年第4期7-13,共7页
We study drifting modulation instability (MI) that exhibits asymmetric discrete spectrum recurrences in the nonlinear stage within the framework of the focusing nonlinear Schr¨odinger equation. We demonstrate tha... We study drifting modulation instability (MI) that exhibits asymmetric discrete spectrum recurrences in the nonlinear stage within the framework of the focusing nonlinear Schr¨odinger equation. We demonstrate that such drifting MI can arise either from the local periodization of general breathers or from numerical simulations starting with an initial modulation containing asymmetric sidebands. 展开更多
关键词 initial modulation containing asymmetric sidebands local periodization numerical simulations general breathers drifting modulation instability asymmetric sideband modulation asymmetric discrete spectrum recurrences spectral portrait
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A universal CNN-Based approach for modulation period estimation 认领 引用
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作者 Xuguang Xu updates Hang Zhu +4 位作者 Ming Tan Xiaojun Zou Wei Song Lixun Han Xuguang Xu 《Defence Technology（防务技术）》 SCIE EI CAS CSCD 2026年第4期69-92,共24页
This paper presents a universal framework for estimating the modulation period of signals with periodic modulation characteristics,applicable to communications,radar,and other radio systems.A key innovation is the int... This paper presents a universal framework for estimating the modulation period of signals with periodic modulation characteristics,applicable to communications,radar,and other radio systems.A key innovation is the introduction of a computationally efficient modulation period spectrum,derived from the dynamic segmentation covariance matrix,which helps mitigate the effects of non-synchronous reception.To resolve estimation ambiguities caused by multiple spectral peaks,a convolutional neural network(CNN)is employed to classify the structural patterns of covariance matrices associated with these peaks,enabling precise period identification.Furthermore,to enhance overall efficiency,a separate CNN-based coarse estimation stage is designed using Hankel covariance cumulative matrices to narrow down the search range prior to refined estimation.Simulation results demonstrate that the proposed two-step approach—coarse search range estimation followed by precise period determination—achieves high accuracy without prior knowledge of the modulation scheme,offering significant advantages in non-cooperative signal processing scenarios. 展开更多
关键词 Modulation period Periodic modulation characteristics Non-synchronous reception Dynamic segmentation covariance matrix Hankel covariance cumulative matrix Convolutional neural network Non-cooperative signal processing
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N,W-Cooperative Modulation of Ni3S2for Efficient Electrocatalytic Oxidation of 5-Hydroxymethylfurfural to 2,5-Furandicarboxylic Acid 认领 引用
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作者 Cheng-Feng Yi Jing-Wen Li +3 位作者 Jia-Rui Li Bing-Chuan Xue Xing Lin Zhi-Gang Liu 《Rare Metals》 SCIE EI CAS CSCD 2026年第2期372-382,共11页
Ni3S2 has emerged as a promising catalyst for the electrochemical oxidation of biomass-derived 5-hydroxymethylfurfural (HMF)to 2,5-furandicarboxylic acid (FDCA),driven by its distinctive physicochemical properti... Ni3S2 has emerged as a promising catalyst for the electrochemical oxidation of biomass-derived 5-hydroxymethylfurfural (HMF)to 2,5-furandicarboxylic acid (FDCA),driven by its distinctive physicochemical properties.However,its practical catalytic efficiency is severely hindered by abundant electrochemically inactive surface sites and poor electronic conductivity.To overcome these challenges,an N,W-cooperative modulation of Ni3S2 catalyst (N,W-Ni3S2),featuring an engineered crystalline-amorphous heterostructure,is designed,utilizing 5,10,15,20-tetraphenylporphine (TPP) as the N source.This innovative architecture integrates W-doped crystalline Ni3S2 and N-doped amorphous carbon,which synergistically enhances charge transport and induces interfacial charge polarization,substantially boosting catalytic activity.The optimized N,W-Ni3S2 demonstrates unprecedented electrocatalytic performance for the oxidation of HMF to FDCA,achieving 100%HMF conversion,97%FDCA yield,and 97%Faradaic efficiency,with over 95%retention in both FDCA yield and Faradaic efficiency across 10 consecutive cycles.Theoretical calculations and experimental results unveil that N incorporation exerts a more profound influence than W in reshaping the electronic landscape of Ni3S2,triggering an asymmetric electron redistribution at the heterogeneous interface.This unique electronic perturbation depletes the electron density around Ni active sites,creating an electron-deficient state that dramatically promotes the in situ generation of NiOOH as the true active species.Furthermore,the tailored electronic environment significantly lowers the energy barrier for the rate-determining step in the oxidation pathway,thereby enabling near-quantitative FDCA production with high efficiency. 展开更多
关键词 2,5-furandicarboxylic acid 5-hydroxymethylfurfural crystalline-amorphous heterostructure N modulation Ni3S2 W modulation
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Evaluation of Reinforcement Learning-Based Adaptive Modulation in Shallow Sea Acoustic Communication 认领 引用
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作者 Yifan Qiu Xiaoyu Yang +1 位作者 Feng Tong Dongsheng Chen 《哈尔滨工程大学学报（英文版）》 CSCD 2026年第1期292-299,共8页
While reinforcement learning-based underwater acoustic adaptive modulation shows promise for enabling environment-adaptive communication as supported by extensive simulation-based research,its practical performance re... While reinforcement learning-based underwater acoustic adaptive modulation shows promise for enabling environment-adaptive communication as supported by extensive simulation-based research,its practical performance remains underexplored in field investigations.To evaluate the practical applicability of this emerging technique in adverse shallow sea channels,a field experiment was conducted using three communication modes:orthogonal frequency division multiplexing(OFDM),M-ary frequency-shift keying(MFSK),and direct sequence spread spectrum(DSSS)for reinforcement learning-driven adaptive modulation.Specifically,a Q-learning method is used to select the optimal modulation mode according to the channel quality quantified by signal-to-noise ratio,multipath spread length,and Doppler frequency offset.Experimental results demonstrate that the reinforcement learning-based adaptive modulation scheme outperformed fixed threshold detection in terms of total throughput and average bit error rate,surpassing conventional adaptive modulation strategies. 展开更多
关键词 Adaptive modulation Shallow sea underwater acoustic modulation Reinforcement learning
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Exact analytical results for a two-level system driven by a pulse with Lorentzian frequency and sub-Lorentzian amplitude modulations 认领 引用
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作者 Qiong-Tao Xie 《Communications in Theoretical Physics》 SCIE CAS CSCD 2026年第3期65-72,共8页
We investigate the dynamics of a two-level quantum system driven by a laser pulse characterized by Lorentzian frequency and sub-Lorentzian amplitude modulations.Complete analytical solutions,expressed via confluent He... We investigate the dynamics of a two-level quantum system driven by a laser pulse characterized by Lorentzian frequency and sub-Lorentzian amplitude modulations.Complete analytical solutions,expressed via confluent Heun functions,are derived.Our analysis reveals that explicit exact analytical solutions exist under infinite sets of specific parameter conditions.The effects of modulation parameters and initial conditions on the final transition probabilities are examined analytically and numerically.Furthermore,the method is demonstrated to be directly applicable to two closely related models with Lorentzian pulses. 展开更多
关键词 exact analytical solutions Lorentzian frequency modulation sub-Lorentzian amplitude modulation two-level system
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Laser-optical-field-modulation fabricating large-aperture dual-band antireflection windows for MWIR and LWIR imaging 认领 引用 被引量：2
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作者 Yulong Ding Cong Wang +8 位作者 Xianshi Jia Linpeng Liu Zheng Gao Xiang Jiang Shiyu Wang Dejin Yan Nai Lin Zhou Li Ji’an Duan 《International Journal of Extreme Manufacturing》 SCIE EI CAS CSCD 2026年第2期560-574,共15页
Dual-band antireflection(DBAR)windows based on surface microstructures offer a promising solution for mid-wave infrared(MWIR)and long-wave infrared(LWIR)co-aperture composite imaging.However,micro-nano manufacturing t... Dual-band antireflection(DBAR)windows based on surface microstructures offer a promising solution for mid-wave infrared(MWIR)and long-wave infrared(LWIR)co-aperture composite imaging.However,micro-nano manufacturing technology faces significant challenges in efficiently producing highly uniform microstructures with characteristic dimensions of∼1μm across hundreds of millimeters.Here,we report a laser optical field modulation(LOFM)technology for the rapid manufacture of ultra-large-scale arrays of antireflection microholes(ARMHs)on large-aperture and non-perfectly planar windows.LOFM technology,which modulates laser pulses in both temporal and spatial domains,enhances ARMH aspect ratios from 0.1 to 0.8 without reducing manufacturing time,and maintains processing accuracy even with laser focus shifts,thereby addressing inconsistencies in large-area processing.As a proof of concept,approximately 7 billion ARMHs are fabricated on a 100-mm-diameter zinc sulfide(ZnS)window at a rate of 20000 holes per second using LOFM technology assisted by machine learning.The fabricated DBAR ZnS window exhibits ultra-broadband(3.5−14μm),high transmittance(91.1%),wide-angle transmission,wear-resistant,and self-cleaning,making it suitable for environments with multiple interference factors.Dual-band imaging applications demonstrate the significant advantages of DBAR windows in target recognition,multi-scenario robustness,and information acquisition. 展开更多
关键词 laser optical field modulation large-aperture window non-perfectly planar antireflection microstructure dual-band infrared imaging
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Modulation of mitochondrial dysfunction:Mechanisms and strategies for the use of natural products to treat stroke 认领 引用 被引量：2
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作者 Na Qin Rujuan Liu +3 位作者 Rong Deng Liuliu Shi Lei Wang Ting Zhu 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第6期2215-2226,共12页
Modulations of mitochondrial dysfunction,which involve a series of dynamic processes such as mitochondrial biogenesis,mitochondrial fusion and fission,mitochondrial transport,mitochondrial autophagy,mitochondrial apop... Modulations of mitochondrial dysfunction,which involve a series of dynamic processes such as mitochondrial biogenesis,mitochondrial fusion and fission,mitochondrial transport,mitochondrial autophagy,mitochondrial apoptosis,and oxidative stress,play an important role in the onset and progression of stroke.With a better understanding of the critical role of mitochondrial dysfunction modulations in post-stroke neurological injury,these modulations have emerged as a potential target for stroke prevention and treatment.Additionally,since effective treatments for stroke are extremely limited and natural products currently offer some outstanding advantages,we focused on the findings and mechanisms of action related to the use of natural products for targeting mitochondrial dysfunction in the treatment of stroke.Natural products achieve neuroprotective through multi-target regulation of mitochondrial dysfunction encompassing the following processes:(1)Mitochondrial biogenesis:Cordyceps and hydroxysafflor yellow A activate the peroxisome proliferator-activated receptor gamma coactivator 1-alphauclear respiratory factor pathway,promote mitochondrial DNA replication and respiratory chain protein synthesis,and thereby restore energy supply in the ischemic penumbra.(2)Mitochondrial dynamics balance:Ginsenoside Rb3 promotes Opa1-mediated neural stem cell migration and diffusion for recovery of damaged brain tissue.(3)Mitochondrial autophagy:Gypenoside XVII selectively eliminates damaged mitochondria via the phosphatase and tensin homolog-induced kinase 1/Parkin pathway and blocks reactive oxygen species and the NOD-like receptor protein 3 inflammasome cascade,thereby alleviating blood-brain barrier damage.(4)Anti-apoptotic mechanisms:Ginkgolide K inhibits Bax mitochondrial translocation and downregulates caspase-3/9 activity,reducing neuronal programmed death induced by ischemia-reperfusion.(5)Oxidative stress regulation:Scutellarin exerts antioxidant properties and improves neurological function by modulating the extracellular signal-regulated kinase 5-Kruppel-like factor 2-endothelial nitric oxide synthase signaling pathway.(6)Intercellular mitochondrial transport:Neuroprotective effects of Chrysophanol are associated with accelerated mitochondrial transfer from astrocytes to neurons.Existing studies have confirmed that natural products exhibit neuroprotective effects through multidimensional interventions targeting mitochondrial dysfunction in both ischemic and hemorrhagic stroke models.However,their clinical translation still faces challenges,such as the difficulty in standardization due to component complexity,insufficient cross-regional clinical data,and the lack of long-term safety evaluations.Future research should aim to integrate new technologies,such as single-cell sequencing and organoid models,to deeply explore the mitochondria-targeting mechanisms of natural products and validate their efficacy through multicenter clinical trials,providing theoretical support and translational pathways for the development of novel anti-stroke drugs. 展开更多
关键词 apoptosis autophagy hemorrhagic stroke ischemic stroke mitochondrial biogenesis mitochondrial dynamics mitochondrial dysfunction modulations mitochondrial transport natural products oxidative stress
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Atomic-scale ultrafast laser processing of nanocrystal with plasmonic modulation for machine learning combined flexible sensor devices 认领 引用 被引量：1
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作者 Ma Luo Jiaqun Li +6 位作者 Jiawang Xie Haoze Han Jianfeng Yan Yuzhi Zhao Yaoyao Li Huhu Cheng Liangti Qu 《International Journal of Extreme Manufacturing》 SCIE EI CAS CSCD 2026年第2期620-638,共19页
Nanometallic materials have attracted wide research attention in the fabrication of functional devices,including flexible electronics circuits and high-sensitive sensors.Sintering of nanometallic materials is generall... Nanometallic materials have attracted wide research attention in the fabrication of functional devices,including flexible electronics circuits and high-sensitive sensors.Sintering of nanometallic materials is generally thought as an effective technology for the functional manufacturing,and the controllable sintering of nanometallic materials and its major mechanisms have long been a challenge.Here,an ultrafast laser processing strategy for Ag nanoparticles(NPs)is achieved by modulating plasmonic.The excitation mode of plasmon can be designed by laser parameters,including polarization with a specific crystal size.The atomic-scale ultrafast dynamics are revealed for understanding the sintering process and design of the sintered structures.The non-equilibrium energy transfer between electron and lattice and dynamic evolution of pressure are proved to be the foremost driving forces on the motion of atomic structures.Through research of plasmonic-induced electric field enhancement and non-uniform deposition of heat and in-situ observation of relative transmittance,mapping from atomic-scale structure to micro behavior is established.Based on plasmonic modulation and processing of Ag NPs,a machine learning combined flexible gesture sensor with high recognition accuracy is displayed.This work expands the knowledge of interactions between lasers and nanometallic materials and provides a method for designing functional devices for a wide range of applications. 展开更多
关键词 ultrafast laser fabrication plasmonic modulation atomic scale processing flexible devices
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Periodontitis-associated salivary microbiota exacerbates systemic osteoclastogenesis via gut modulation and tryptophan metabolism suppression in ovariectomized mice 认领 引用
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作者 Nannan Wang Jun Qian +7 位作者 Min Wang Lili Li Wenzheng Liao Rixin Chen Hua Nie Ruiyang Ge Fangfang Sun Fuhua Yan 《International Journal of Oral Science》 SCIE CAS CSCD 2026年第1期152-164,共13页
Epidemiological studies have highlighted an association between periodontitis and osteoporosis.However,the mechanism underlining this association remains unclear.Here,we revealed significant differences in the salivar... Epidemiological studies have highlighted an association between periodontitis and osteoporosis.However,the mechanism underlining this association remains unclear.Here,we revealed significant differences in the salivary microbiota between periodontally healthy individuals and periodontitis patients,with periodontitis patients exhibiting increased salivary microbiota diversity and an elevated abundance of pathogenic bacteria.Using an ovariectomized(OVX) mouse model,we demonstrated that the salivary microbiota from periodontitis patients exacerbated bone destruction by modulating the gut microbiota.Metabolomic analysis revealed that the periodontitis-associated salivary microbiota suppressed tryptophan metabolism.The tryptophan metabolite indole-3-lactic acid(ILA) directly inhibited osteoclast formation and differentiation.In OVX mice treated with periodontitis salivary microbiota,supplementation with ILA effectively suppressed osteoclastogenesis and alleviated the detrimental effects of periodontitis-associated salivary microbiota on systemic bones.In summary,our data demonstrate that periodontitis can affect systemic bone metabolism via the oral-gut axis and that ILA supplementation serves as a potential therapeutic option to mitigate these adverse effects. 展开更多
关键词 tryptophan metabolism salivary microbiota periodontitis osteoclastogenesis pathogenic bacteriausing epidemiological studies indole lactic acid gut modulation
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Sub-100 Femtosecond All-Optical Modulation Beyond Electron-Phonon Limits 认领 引用
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作者 Renxian Gao Jiayu Li +6 位作者 Xiaoxiang Dong Yonglin He Wenbin Chen Peiwen Ren Xiaoyu Zhao Ming‑De Li Zhilin Yang 《Nano-Micro Letters》 SCIE EI CAS CSCD 2026年第9期504-515,共12页
Ultrafast all-optical modulators are central to the advancement of next-generation photonic computing and signal-processing systems.However,the intrinsic electron–phonon relaxation bottleneck in plasmonic materials h... Ultrafast all-optical modulators are central to the advancement of next-generation photonic computing and signal-processing systems.However,the intrinsic electron–phonon relaxation bottleneck in plasmonic materials has long constrained modulation speeds to the picosecond regime,hindering the realization of sub-100 fs modulation.Here,we report a metastructured silver–single-crystal silicon nanodisk antenna that delivers experimentally resolved sub-100 fs alloptical modulation.Distinct from conventional planar metal–semiconductor junctions,the nanodisk architecture spatially co-localizes plasmonic energy deposition with the metal–semiconductor transfer boundary within a nanoscale-confined volume.This configuration markedly shortens hot-carrier transport pathways and preferentially activates interfacial carrier extraction during the earliest relaxation stage,thereby establishing an interface-dominated modulation pathway that precedes electron–phonon thermalization.By enabling modulation on timescales comparable to intrinsic electronic response limits,this work establishes a physical foundation for ultrafast photonic modulation,including femtosecond free-space photonic computing architectures,temporal optical gating,and other ultrafast systems constrained by carrier or cavity lifetimes. 展开更多
关键词 Sub 100 fs all Optical modulation Silver Silicon metastructure Interfacial hot Carrier dynamics
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Design and optimization of area-selective carrier modulation in β-Ga2O3through high temperature oxygen annealing 认领 引用
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作者 Qiuyan Li Qiming He +3 位作者 Jinyang Liu Xuanze Zhou Guangwei Xu Shibing Long 《Chinese Physics B》 SCIE EI CAS CSCD 2026年第5期227-234,共8页
Carrier modulation in beta-gallium oxide(β-Ga2O3)films through an oxygen annealing method is systematically investigated,including annealing time and annealing cap layer(ACL)design.Capacitance-voltage measureme... Carrier modulation in beta-gallium oxide(β-Ga2O3)films through an oxygen annealing method is systematically investigated,including annealing time and annealing cap layer(ACL)design.Capacitance-voltage measurement conducted on vertical SBD structures was used to evaluate the carrier concentration after annealing.The formation of a“surface layer”may suppress the diffusion of oxygen species as the annealing time increases.An 8-hour annealing time resulted in a carrier modulation with an approximately 3-µm-deep low-carrier-concentration layer.The annealing cap layer,consisting of polySi and SiO2,was deposited and patterned to achieve area-selective carrier modulation inβ-Ga2O3.The effective thickness of poly-Si for blocking oxygen diffusion was confirmed by scanning electron microscopy(SEM)for the first time.A definite thickness of SiO2served as both etching stop layer and lift-off layer for poly-Si.According to simulation results,the non-ideal surface caused extra high peak electric field in theβ-Ga2O3device.A combination of an optimized dry etching method and low-compressive-stress deposition technology was employed to eliminate the bird's beak-like shape structure that appeared at the edges of the patterns and bulges on theβ-Ga2O3surface after annealing.The feasibility of the carrier modulation technology enables the diversity ofβ-Ga2O3devices fabrication. 展开更多
关键词 Ga2O3 oxygen annealing carrier modulation power device
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Electronic modulation of Pd nanoparticles by thioether-functionalized covalent organic framework for efficient ethanol oxidation 认领 引用
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作者 Haichang Fu Zihan Zhou +9 位作者 Yiting Zhang Yukun Gu Yuheng Yang Kexin Li Xinyu Li Hua Yan Yanxian Jin Dan Chen Kai Huang Zhangxin Chen 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2026年第7期426-436,I0011,共11页
Developing electrocatalysts that combine high catalytic activity with efficient C-C bond cleavage remains a major challenge in the ethanol oxidation reaction(EOR).Tuning the electronic metal-support interaction(EMSI)h... Developing electrocatalysts that combine high catalytic activity with efficient C-C bond cleavage remains a major challenge in the ethanol oxidation reaction(EOR).Tuning the electronic metal-support interaction(EMSI)has attracted considerable attention as a promising strategy for designing high-performance catalysts.Herein,we report the rational design of a thioether-functionalized covalent organic framework(COF-S)via thiol-ene click chemistry.The strong interaction between the thioether groups and Pd nanoparticles(NPs)enables effective immobilization of Pd NPs within the COF-S framework.The resulting Pd/COF-S catalyst exhibits exceptional activity and stability for the EOR,delivering a mass activity of 2.99 A mgPd-1—substantially higher than those of Pd/COF-V(1.60 A mgPd-1)and commercial Pd/C(0.58 A mgPd-1).In situ FTIR spectroscopy combined with theoretical calculations reveals that the thioether-containing Pd/COF-S catalyst promotes C-C bond cleavage during the EOR.The introduction of thioether groups optimizes the electronic structure of Pd by up-shifting its d-band center,which facilitates C-C bond cleavage and enhances the catalytic activity performance.This work offers an effective strategy for boosting the activity and selectivity of Pd-based catalysts through rational support design and electronic structure modulation. 展开更多
关键词 Electronic modulation Thiol-ene click chemistry Covalent organic framework Pd catalysts Ethanol electrooxidation
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Facet modulation promotes synergy between TiO2 nanomaterials and dissolved organic matter in photocatalytic generation of reactive oxygen species 认领 引用
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作者 Qianwu Wang Fangru He +4 位作者 Yaqi Liu Jingxiang Low Chuanjia Jiang Tong Zhang Wei Chen 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第7期253-260,共8页
The efficiency of reactive oxygen species(ROS)generation is the most critical factor controlling the performance of photocatalytic water treatment.Dissolved organic matter(DOM),a ubiquitous and photoedox-active consti... The efficiency of reactive oxygen species(ROS)generation is the most critical factor controlling the performance of photocatalytic water treatment.Dissolved organic matter(DOM),a ubiquitous and photoedox-active constituent in natural and waste waters,may significantly interfere with the rate and pathways of ROS generation.Here,we show that modulating exposed facets of nano-catalysts to regulate the interactions between DOM and nanomaterials can boost ROS production.Specifically,electron paramagnetic resonance spectroscopy and probe test demonstrate that the production rate of superoxide radical anion(O2•-)in a system containing{001}-faceted TiO2nanocrystals and humic/fulvic acid far exceeds those in the systems containing TiO2or DOM alone.In comparison,the synergy between{101}-faceted nano-TiO2and humic/fulvic acid is much less prominent.Enhanced production of singlet oxygen(1O2)is also observed for{001}-faceted nano-TiO2in the presence of DOM,whereas 1O2production by{101}-faceted TiO2is subdued by DOM.Moreover,the{001}-faceted material is much more robust against the inhibition effect of DOM on hydroxyl radical(•OH)production.Thermogravimetric analysis reveals distinct DOM adsorption capacities between the materials.By spectroscopic and electrochemical analyses,we further elucidate the structure-activity relationship between exposed facets and rate-limiting factors in ROS generation.Exposed facets regulate the specific mode of interaction between TiO2 and DOM,which subsequently determines the charge carrier separation,adsorption of O2,as well as quenching of photogenerated holes and ROS.The findings provide deeper insights for improving the efficacy of photocatalytic water treatment through facet engineering of semiconductors. 展开更多
关键词 Facet modulation Reactive oxygen species Photocatalytic water treatment Nanomaterials Dissolved organic matter
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Beyond conventional therapies:Gut microbiota modulation and macromolecular drugs in the battle against cardiometabolic diseases 认领 引用
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作者 Jingyue Wang Jing Qu +7 位作者 Mengliang Ye Ru Feng Xiang Hui Xinyu Yang Jingyu Jin Qian Tong Xianfeng Zhang Yan Wang 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2026年第1期100-119,共20页
Cardiometabolic diseases(CMDs)represent an ongoing major global health challenge,driven by complex interactions among genetic,environmental,microbiome-related,and other factors.While smallmolecule drugs and lifestyle ... Cardiometabolic diseases(CMDs)represent an ongoing major global health challenge,driven by complex interactions among genetic,environmental,microbiome-related,and other factors.While smallmolecule drugs and lifestyle interventions can provide clinical benefits,they are possible to be constrained by the limited druggability of key target proteins,the potential risks of off-target effects,and difficulties in maintaining long-term adherence.In recent years,gut microbiota modulation and macromolecular drugs have emerged as promising therapeutic strategies.Gut microbiota modulation(e.g.,probiotics,synbiotics,or natural products)exerts systemic metabolic and immune effects,supporting a therapeutic approach targeting multiple diseases.Meanwhile,macromolecular drugs(e.g.,peptides,antibodies,and small nucleic acids)offer precise,pathway-targeted interventions.Despite advancements,limitations remain in addressing ethical considerations in microbiota modulation and optimizing targeted delivery systems,all of which may hinder clinical translation.Here,we provide a comprehensive overview of therapeutic approaches for CMDs,with a focus on obesity,type 2 diabetes mellitus(T2DM),and atherosclerosis(AS).The review is structured around three key aspects:i)conventional therapies,including small-molecule drugs and lifestyle interventions;ii)emerging therapies encompassing gut microbiota modulation,macromolecular drugs,and their interactions;and iii)challenges and opportunities for comorbidity management,microbiota ethics,and artificial intelligence(AI)-driven therapeutic optimization.We hope this review enhances the understanding of smallmolecule drugs,lifestyle interventions,gut microbiota modulation,and macromolecular drugs in the management of CMDs,thereby fostering medical innovation and contributing to the development of system-based comprehensive therapeutic paradigms. 展开更多
关键词 Cardiometabolic diseases Conventional therapies Gut microbiota modulation Macromolecular drugs Opportunities
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Dual-region synergistic modulation and (101) facet engineering for highly reversible zinc anodes 认领 引用
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作者 Shuai Zhang Kittima Lolupiman +5 位作者 Dongdong Zhang Zixuan Gao Rungroj Chanajaree Xinyu Zhang Jin Cao Jiaqian Qin 《Advanced Powder Materials》 EI CAS CSCD 2026年第1期99-111,共13页
Aqueous zinc-ion batteries(AZIBs)offer promising safety and affordability,but suffer from dendritic Zn growth and parasitic side reactions at the electrode-electrolyte interface.Herein,we construct a dual-region inter... Aqueous zinc-ion batteries(AZIBs)offer promising safety and affordability,but suffer from dendritic Zn growth and parasitic side reactions at the electrode-electrolyte interface.Herein,we construct a dual-region interfacial modulation framework by molecularly reconfiguring the Helmholtz double layer via trace methyl methacrylate(MMA).Exploiting its amphiphilic and functionally asymmetric architecture,MMA enables a coordinated interfacial reconstruction that disrupts Zn2+solvation in the outer Helmholtz plane,builds a chemisorbed coordination layer in the inner plane,and modulates local interfacial chemistry with spatial precision.This dualregion regulation collectively suppresses water reactivity,facilitates Zn2+desolvation,and drives crystallo-graphically preferred deposition along the(101)plane,promoting lateral growth and mitigating dendrite for-mation.As a result,symmetric Zn||Zn cells exhibit over 4200 h of stable cycling at 1 mA cm-2 and maintain 1100 h of operation at 2 mA cm-2,even at 0℃.Zn||Ti half-cells achieve a Coulombic efficiency of 99.83%,while Zn||NH4V4O10 full cells deliver 93.92%capacity retention after 400 cycles at 2 A g-1,and preserve 85.3%after 300 cycles at 0℃.This work demonstrates a scalable,mechanism-driven electrolyte design paradigm for dendrite-free and high-performance aqueous Zn metal batteries. 展开更多
关键词 Aqueous zinc-ion batteries Helmholtz plane engineering Dendrite suppression Solvation modulation Facet-selective Zn deposition
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Magnetic-Field Modulation of Na3V2(PO4)3Crystal Orientation for Enhanced Sodium-Ion Battery Performance 认领 引用
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作者 Pengcheng Wang Xuqi Lin +6 位作者 Houlin Cheng Ciqi Yuan Yongping Zheng Yingbin Lin Zhigao Huang Hao Chen Jiaxin Li 《Carbon Energy》 SCIE EI CAS CSCD 2026年第2期221-235,共15页
Na3V2(PO4)3(NVP)is a promising electrode material that exhibits magnetic anisotropy;however,the potential of this magnetic anisotropy to optimize battery performance has been largely unexplored.This study ... Na3V2(PO4)3(NVP)is a promising electrode material that exhibits magnetic anisotropy;however,the potential of this magnetic anisotropy to optimize battery performance has been largely unexplored.This study proposes a cost-effective and efficient method to induce the alignment of NVP along the(113)crystal plane by applying a vertical magnetic field during the slurry coating process,thereby enhancing its battery performance.Comprehensive structural characterizations and theoretical analysis elucidate the structure-activity relationship between the preferred crystal orientation and ion transport kinetics,facilitating the formation of more ordered Na+deintercalation pathways in NVP electrodes.This alignment reduces electrode tortuosity,enhances interfacial compatibility,and substantially improves battery performance,particularly in terms of high-rate cycling capability.As a result,the magnetic-field-modulated NVP(NVP-M⊥)electrode exhibits a high capacity retention of85.1%after 500 cycles at 5 C,significantly surpassing that of the pristine electrode.The NVP-M⊥electrode also demonstrates considerable reversible capacity at 40 C and maintains excellent stability under high temperature and prolonged cycling conditions.Furthermore,superior battery performance is observed in the assembled NVP-M⊥‖hard-carbon pouch cell and commercial NVP electrode following magnetic-field modulation,thereby validating the efficacy of this method.Consequently,this magnetic-field-induced crystal-orientation optimization strategy provides an innovative approach for low-cost and highthroughput preparation of high-performance sodium-ion batteries. 展开更多
关键词 battery performance magnetic‐field modulation Na3V2(PO4)3cathode sodium‐ion batteries thermalsafety
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Peak current reduction in presence of RF phase modulationin the dual RF system 认领 引用
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作者 Jiang Bocheng Zhang Yao Tsai Cheng-Ying 《强激光与粒子束》 CAS CSCD 北大核心 2026年第1期160-165,共6页
[Background]High harmonic cavities are widely used in electron storage rings to lengthen thebunch,lower the bunch peak current,thereby reducing the IBS effect,enhancing the Touschek lifetime,as well asproviding Landau... [Background]High harmonic cavities are widely used in electron storage rings to lengthen thebunch,lower the bunch peak current,thereby reducing the IBS effect,enhancing the Touschek lifetime,as well asproviding Landau damping,which is particularly important for storage rings operating with ultra-low emittance or atlow beam energy.[Purpose]To further increase the bunch length without additional hardware costs,the phasemodulation in a dual-RF system is considered.[Methods]In this paper,turn-by-turn simulations incorporating randomsynchrotron radiation excitation are conducted,and a brief analysis is presented to explain the bunch lengtheningmechanism.[Results]Simulation results reveal that the peak current can be further reduced,thereby mitigating IBSeffects and enhancing the Touschek lifetime.Although the energy spread increases,which tends to reduce thebrightness of higher-harmonic radiation from the undulator,the brightness of the fundamental harmonic can,in fact,beimproved. 展开更多
关键词 dual high-frequency system phase modulation beam bunch stretching intra-beam scattering
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Digital neuroplasticity modulation of the brain-immune axis:Translational strategies for neurodegenerative,psychiatric,and aging-related conditions 认领 引用
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作者 Merav Catalogna Amir Amedi 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第10期4914-4915,共2页
The brain-immune axis:The dynamic interplay between neural and immune systems is emerging as a fundamental regulator of cognitive processes,affective balance,and resilience to pathological challenges(Castellani et al.... The brain-immune axis:The dynamic interplay between neural and immune systems is emerging as a fundamental regulator of cognitive processes,affective balance,and resilience to pathological challenges(Castellani et al.,2023).Although these systems detect and respond to distinct types of stimuli,their domains of perception and response substantially overlap. 展开更多
关键词 psychiatric conditions translational strategies brain immune axis digital neuroplasticity modulation neural immune systems affective balance cognitive processes neurodegenerative conditions
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Complexity-Reduced Equalization for 200 Gbit/s PON Downstream Systems Based on SSB Modulation and Direct Detection 认领 引用
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作者 Yang Tao Huang Xingang +3 位作者 Ma Zhuang Zhong Yiming Huang Xiatao Liu Bo 《ZTE Communications》 2026年第1期56-64,共9页
The 200 Gbit/s passive optical network(PON)is most likely to be the next-generation scheme following 50G PON.The costeffective direct detection(DD)system is the economical choice.However,larger-capacity DD systems wil... The 200 Gbit/s passive optical network(PON)is most likely to be the next-generation scheme following 50G PON.The costeffective direct detection(DD)system is the economical choice.However,larger-capacity DD systems will face much more serious power fading caused by chromatic dispersion(CD)combined with square-law DD and thereby significantly increases the complexity of equalization algorithms.In this paper,a 200 Gbit/s Nyquist 4-level pulse amplitude modulation(PAM4)single side-band(SSB)modulation-DD downlink scheme is designed,and a low complexity quadratic-nonlinear equalizer is proposed for this system.The computational complexity of the quadratic nonlinear equalizer is about 28%of that of the conventional Volterra nonlinear equalizer,while still exhibiting excellent nonlinear equalization ability.Simulation results for the 200 Gbit/s system with 20 km fiber transmission show that it can achieve a power budget of 29 dB,while a 30.4 dB power budget is obtained in the 50 Gbit/s experimental transmission. 展开更多
关键词 200 Gbit/s passive optical network single side band modulation direct detection equalization
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Investigation on optical sinc-shaped Nyquist pulse generation based on external modulation 认领 引用
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作者 Jin YUAN Xiuxiu XU 《Optoelectronics Letters》 EI 2026年第2期82-86,共5页
In this paper, a scheme for generating sinc-shaped optical Nyquist pulses based on external modulation is proposed. First, five flat optical frequency comb(OFC) lines are generated by a dual-parallel Mach–Zehnder mod... In this paper, a scheme for generating sinc-shaped optical Nyquist pulses based on external modulation is proposed. First, five flat optical frequency comb(OFC) lines are generated by a dual-parallel Mach–Zehnder modulator(DP-MZM) for optical carrier phase cancellation interference. Then, the phase-locked OFC is split into two paths, one of which is transmitted to a single-drive Mach–Zehnder modulator(SD-MZM) for the modulation of the even-order side-band suppression, and the other is used to remodulate the signal in order to obtain equally spaced comb lines. Eventually, equal frequency spaced phase-locked 15-line OFCs are generated and extremely narrow over-zero width Nyquist pulses are realized at 2.5 GHz, 5 GHz, 10 GHz and 20 GHz. The root-mean-square error(RMSE) is calculated for the generated Nyquist pulses which enables the verification of the signal quality. 展开更多
关键词 remodulate s dual parallel Mach Zehnder modulator phase locked optical frequency comb external modulation optical carrier phase cancellation interference flat optical frequency single drive Mach Zehnder modulator optical sinc shaped Nyquist pulses
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