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Decoding cellular communication networks and signaling pathways in bone,skeletal muscle,and bone-muscle crosstalk through spatial transcriptomics in a young male mouse 认领 引用
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作者 Chuan Qiu Yisu Li +16 位作者 Yun Gong William Sherman Di Tian Weiqiang Lin Zehui Pan Boluwatife Afolabi Vivek Thumbigere Kuanjui Su Jeffrey Deng Yuwei Hou Shashank Mungasavalli Gnanesh Zhe Luo Qing Tian Fernando Sanchez Yiping Chen Hui Shen Hong-Wen Deng 《Bone Research》 SCIE CAS CSCD 2026年第3期920-934,共15页
Bone and skeletal muscle are essential components of musculoskeletal system,enabling movement,load-bearing,and systemic homeostasis.These tissues communicate through dynamic bone-muscle crosstalk mediated by cytokines... Bone and skeletal muscle are essential components of musculoskeletal system,enabling movement,load-bearing,and systemic homeostasis.These tissues communicate through dynamic bone-muscle crosstalk mediated by cytokines,growth factors,and extracellular-matrix(ECM)proteins.The spatial organization of these mediators is critical for maintaining tissue integrity,and its disruption contributes to diseases,such as osteoporosis,sarcopenia,and metabolic syndrome.Despite this importance,spatial transcriptomics(ST)studies of bone-muscle interactions remain limited.Here,we applied 10x Genomics Visium ST with computational tools,e.g.,SMART and CellChat,to deconvolute cell-type composition and characterize cell-cell communication networks and ligand-receptor(L-R)interactions in mouse femur and adjacent skeletal muscle.We identified eight major cell types(erythroid cells,endothelial cells,skeletal muscle cells,osteoblasts,myeloid cells,monocytes/macrophages,mesenchymal stem cells,and adipocytes)with distinct spatial transcriptional profiles and thirteen CellChat-inferred pathways,such as ECM-receptor related(e.g.,COLLAGEN,TENASCIN,THBS)and secreted-signaling involved(e.g.,VEGF)pathways.Representative L-R pairs include Col1a1/Col1a2-Sdc4,mediating osteoblast-to-muscle interactions,and Col4a1-Sdc4,facilitating muscle-to-osteoblast interactions in COLLAGEN,Tnxb-Sdc4 in TENASCIN,supporting muscle-to-osteoblast/muscle/myeloid/endothelial communication,Comp-Sdc4 in THBS,driving monocyte/macrophage-to-osteoblast/muscle signaling,and Vegfa-Vegfr1/Vegfr2 in VEGF,mediating muscle-toendothelial/myeloid signaling.Immunostaining validated colocalization of several representative L-R pairs with their corresponding cells.Additionally,independent mouse and human bone scRNA-seq datasets reproduced most of the pathways and L-R pairs identified in ST,underscoring the robustness and cross-species relevance of our findings.Together,we present an initial spatially resolved transcriptome-wide map of bone-muscle intercellular communication,providing novel insights into molecular crosstalk and establishing groundwork for future studies in musculoskeletal disorders. 展开更多
关键词 skeletal muscle cells bone muscle crosstalk spatial transcriptomics osteoblasts signaling pathways young male mouse musculoskeletal systemenabling bone skeletal muscle
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Load-induced human skeletal muscle hypertrophy:Mechanisms,myths,and misconceptions 认领 引用 被引量：1
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作者 Derrick W.Van Every Matthew J.Lees +2 位作者 Brandan Wilson Jeff Nippard Stuart M.Phillips 《Journal of Sport and Health Science》 SCIE CAS CSCD 2026年第4期271-286,共16页
Mechanical tension is widely recognized as the primary stimulus underlying the molecular mechanisms that influence muscle hypertrophy induced by resistance training.Despite this,several outdated or overstated concepts... Mechanical tension is widely recognized as the primary stimulus underlying the molecular mechanisms that influence muscle hypertrophy induced by resistance training.Despite this,several outdated or overstated concepts continue to persist,both in the scientific literature and in the practical application of resistance training coaching and program design.Claims that acute hormonal responses,metabolic stress,cell swelling or“the pump”meaningfully contribute to hypertrophy are not supported by scientific evidence.Additionally,the concept of sarcoplasmic hypertrophy as a distinct and functionally meaningful contributor to hypertrophy lacks strong evidence.In this review,we critically evaluate several persistent misconceptions and contrast them with evidence-based mechanistic insights into load-induced hypertrophy.Specifically,we discuss the role(or lack thereof)of systemic hormones,metabolites,and cell swelling in promoting muscle hypertrophy.We also critically review the concept of sarcoplasmic hypertrophy and propose that it is not a meaningful contributor to muscle hypertrophy.Lastly,to translate knowledge for trainees and coaches,we discuss the upper limit of muscle hypertrophy and provide readers with evidence-based,reasonable expectations for muscle hypertrophy.We aimed,through this review,to use scientific evidence to enhance our understanding of what drives muscle hypertrophy and provide an evidence-based framework for resistance exercise training. 展开更多
关键词 Mechanical tension Muscle mass Resistance training Skeletal muscle
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A novel contralateral ulnar nerve transfer model for selective muscle reinnervation in upper motor neuron syndrome 认领 引用
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作者 Olga Politikou Silvia Muceli +10 位作者 Leopold Harnoncourt Florian Jaklin Vlad Tereshenko Udo Maierhofer Matthias Luft Christopher Festin Gregor Laengle Johanna Klepetko Laurenz Pflaum Konstantin D.Bergmeister Oskar C.Aszmann 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第8期3748-3753,共6页
Stroke and traumatic brain injury lead to upper motor neuron syndrome,which is characterized by muscle spasticity or paresis of varying severity depending on the lesion’s location and extent.Current treatments are mo... Stroke and traumatic brain injury lead to upper motor neuron syndrome,which is characterized by muscle spasticity or paresis of varying severity depending on the lesion’s location and extent.Current treatments are mostly symptomatic with limited efficacy and significant side effects.Nerve transfer techniques,such as the contralateral L4 ventral root transfer in animal models and C7 root transfer in both animal and clinical studies,have been shown to reduce spasticity and improve function in upper motor neuron syndrome;however,they lack selectivity.Our hypothesis is that using a selective peripheral donor nerve from the contralateral side,rather than the entire nerve root,may represent an effective nerve transfer and provide a robust basis for future research on selective muscle reinnervation in upper motor neuron syndrome.Ten rats underwent a contralateral ulnar-to-ulnar nerve transfer procedure.Electrophysiological measurements were conducted twelve weeks post-surgery to assess successful reinnervation of the contralateral flexor carpi ulnaris muscle.Additionally,muscle biopsies of the reinnervated flexor carpi ulnaris were harvested to examine the muscle fiber type composition,cross-sectional area,and collagen content as well as compare them to naive counterparts.Axon quantification of the reinnervated nerves was also performed.All rats recovered uneventfully,maintaining the use of both paws post-surgery.Electrophysiological tests confirmed the successful reinnervation of the flexor carpi ulnaris muscle.Muscle fiber type composition,cross-sectional area,and collagen content did not show statistically significant changes.Axon counts indicated successful nerve regeneration without architectural disruption.In conclusion,we were able to demonstrate this novel contralateral nerve transfer model’s feasibility,reproducibility,and safety as well as achieve effective muscle reinnervation.This model provides a valuable tool for further research on selective muscle reinnervation and treatment of upper motor neuron syndrome,with potential implications for improving clinical outcomes in stroke and traumatic brain injury patients. 展开更多
关键词 electrophysiology hemiplegia muscle fiber type muscle reinnervation nerve regeneration nerve transfer spasticity stroke ulnar nerve upper motor neuron lesion
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Three-dimensional psoas muscle volume and longitudinal changes as predictors of outcomes in older patients with advanced pancreatic cancer 认领 引用
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作者 Yu Akazawa Masahiro Ohtani +5 位作者 Yosuke Murata Tomoko Tanaka Takuto Nosaka Kazuto Takahashi Tatsushi Naito Yasunari Nakamoto 《World Journal of Gastroenterology》 SCIE CAS 2026年第24期82-96,共15页
BACKGROUND Pancreatic cancer(PC)has one of the poorest prognoses among malignant diseases worldwide.In chemotherapy for advanced PC,the anti-tumor effect and tolerability often vary among patients,and reliable biomark... BACKGROUND Pancreatic cancer(PC)has one of the poorest prognoses among malignant diseases worldwide.In chemotherapy for advanced PC,the anti-tumor effect and tolerability often vary among patients,and reliable biomarkers to predict these outcomes remain unclear.Sarcopenia is recognized as an important prognostic factor in various cancers,and three-dimensional(3D)skeletal muscle volumetric analysis has recently emerged as an objective method for evaluating muscle status.However,the clinical and prognostic implications of volumetric skeletal muscle assessment in older patients with advanced PC undergoing gemcitabine plus nab-paclitaxel therapy have not been fully clarified.AIM To clarify the usefulness of 3D muscle volumetric analysis in predicting tolerability and prognosis in older patients with advanced PC.METHODS We retrospectively enrolled 150 older patients(aged≥65 years)with unresectable PC,including those with locally advanced and/or metastatic disease,who received first-line gemcitabine plus nab-paclitaxel therapy and evaluated the impact of sarcopenia on time to treatment failure(TTF),overall survival(OS),and progression-free survival(PFS).Psoas muscle volume was semi-automatically measured using a 3D image analysis system,and sarcopenia was defined by sex-specific psoas volume index cutoffs.Additionally,longitudinal muscle changes at baseline and two months after treatment initiation were evaluated to determine their prognostic relevance.RESULTS Forty-six(30.7%)patients were diagnosed with sarcopenia;the median TTF was significantly shorter in sarcopenic patients(59 days vs 211 days;Pgrade 3)occurred more frequently in patients with sarcopenia than in those without(47.8%vs 26.9%;P=0.015).Among 135 patients with sequential imaging,the non-sarcopenia-maintenance group(n=72)showed significantly longer OS(median 615 days)than the sarcopenia-progression(n=25;205 days)and sarcopenia-maintenance groups(n=35;185 days;P<0.001).CONCLUSION Sarcopenia defined by 3D psoas volume index and early muscle deterioration were strongly associated with poor tolerability and survival,indicating that volumetric assessment may predict outcomes in older patients with advanced PC. 展开更多
关键词 Pancreatic cancer Chemotherapy Sarcopenia Skeletal muscle volumetric analysis Muscle volume dynamics Tolerability Prognosis
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Effect of percussive massage treatment and static stretching on muscle tone,stiffness,and strength recovery after exercise-induced muscle fatigue:A randomized controlled study 认领 引用
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作者 Gangrui Chen Zhongke Gu +2 位作者 Dongling Xin Yuxuan Qi Jiansong Dai 《Sports Medicine and Health Science》 CAS CSCD 2026年第5期524-530,共7页
The aim of this study was to compare the effects of percussive massage treatment and static stretching on muscle tone,stiffness,and strength recovery following exercise fatigue.Sixty subjects were randomly divided int... The aim of this study was to compare the effects of percussive massage treatment and static stretching on muscle tone,stiffness,and strength recovery following exercise fatigue.Sixty subjects were randomly divided into three groups:a control group(CG,n=20),a static stretching group(SSG,n=20),and a percussive massage treatment group(PMTG,n=20).Following exercise-induced muscle fatigue,interventions were applied,including supine rest,static stretching,and percussive massage treatment.Muscle tone,stiffness,and muscle strength indicators were assessed at five time points:before the exercise(Pre-exercise),immediately after exercise(Post-exercise),immediately after therapy intervention(Post-0),24 hours(h)after therapy intervention(Post-24 h),and 48 h after therapy intervention(Post-48 h).Results:At Post-0,muscle tone and stiffness in both the control group and static stretching group were significantly higher than Pre-exercise,while in the percussive massage treatment group,there were no statistically significant differences compared to Pre-exercise.At Post-48 h,peak torque in the control group was significantly lower than Pre-exercise.In contrast,the percussive massage treatment group and static stretching group showed no significant differences at Post-48 h compared to Pre-exercise.These findings indicated that percussive massage therapy is immediately effective in mitigating muscle tone and stiffness after exercise fatigue,whereas static stretching and percussive massage therapy facilitate the recovery of muscle strength within 48 h. 展开更多
关键词 Percussive massage therapy Static stretching Muscle tone and stiffness Muscle strength
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Molecular signaling effects of electrical stimulation of the soleus muscle during 6 days of dry immersion 认领 引用
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作者 Kristina A.Sharlo Irina D.Lvova +7 位作者 Natalya A.Vilchinskaya Sergey A.Tyganov Olga V.Turtikova Ksenia V.Sergeeva Roman O.Bokov Boris S.Shenkman Elena S.Tomilovskaya Oleg I.Orlov 《Sports Medicine and Health Science》 CAS CSCD 2026年第3期335-349,共15页
Background:Unloading of skeletal muscles triggers rapid changes in molecular signaling,leading to muscle atrophy and functional alterations.Electrical stimulation of muscles is commonly used to counteract these change... Background:Unloading of skeletal muscles triggers rapid changes in molecular signaling,leading to muscle atrophy and functional alterations.Electrical stimulation of muscles is commonly used to counteract these changes,but the precise molecular mechanisms behind its effects remain unclear.Methods:To investigate the early changes in postural soleus muscle under unloading conditions(dry immersion,DI)and the impact of electrical stimulation during unloading,two groups of volunteers(10 men in each)underwent a 6-day DI or a 6-day DI with electrical stimulation(DI+ES).Soleus muscle samples were collected 14 days before and 6 days after DI and DI+ES.Results:Six-day DI did not did not cause atrophy of the soleus myofibers or alter protein synthesis parameters,However,it did lead to an increase in atrogin-1 expression,a downregulation of markers for mitochondrial biogenesis and dynamics,and a decline in the mRNA expression of fast oxidative myosin isoform IIa.It also resulted in the downregulation of microRNAs mir-206 and mir-208b,which support slow fiber types.There was an upregulation of CpG methylation in the peroxisome proliferator-activated receptor gamma coactivator 1-alpha(PGC1a)promoter region and an accumulation of Ca2+/calmodulin-dependent protein kinase(p-CaMK II),indicating an increase in myoplasmic calcium levels.Electrical stimulation during the 6-day disuse period prevented the disuse-induced decreases in mitochondria-related markers and the content of mir-206 and mir-208b.It also induced a shift in myosin m RNA expression from types IId/x to IIa,counteracted the accumulation of p-CaMK II and CpG methylation in the PGC1a promoter region.Conclusions:Electrical stimulation upregulated markers of both protein synthesis and proteolysis,as well as resulted in lower cross-sectional area of fast-type fibers compared to pre-DI+ES. 展开更多
关键词 Dry immersion Muscle disuse Electrical stimulation Muscle signaling
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Does ice affect healing after muscle injury?Ask me again next century 认领 引用
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作者 Chris Bleakley 《Journal of Sport and Health Science》 SCIE CAS CSCD 2026年第4期325-328,共4页
Debate over the benefits and harms of icing acute muscle injuries remains unresolved.Some contend that ice is ineffective or even harmful,while others promote cryotherapy as a universal remedy.Centrists,often academic... Debate over the benefits and harms of icing acute muscle injuries remains unresolved.Some contend that ice is ineffective or even harmful,while others promote cryotherapy as a universal remedy.Centrists,often academics,call for more high-quality randomized controlled trials(RCTs)to resolve the issue.This viewpoint reframes the debate around 3 key points:first,although ice produces analgesia,evidence for sustained pain relief,beyond the immediate post-treatment period. 展开更多
关键词 cryotherapy icing acute muscle injuries analgesia muscle injury randomized controlled trials ice healing randomized controlled
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Exercise training-induced extracellular miR-136-3p modulates glucose uptake and myogenesis through targeting of NRDC in human skeletal muscle 认领 引用 被引量：2
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作者 Mutsumi Katayama Elena Caria +8 位作者 Dimitri Van Simaeys Anna Yagüe Sanz Romain Barrès Kenneth Caidahl Oscar P.B.Wiklander Samir El Andaloussi Per-Olof Berggren Juleen R.Zierath Anna Krook 《Journal of Sport and Health Science》 SCIE CAS CSCD 2026年第1期40-55,共16页
Background Regular physical training induces adaptive effects across multiple organ systems,highlighting the existence of inter-organ communication networks.However,the molecular mechanisms underlying both exercise-in... Background Regular physical training induces adaptive effects across multiple organ systems,highlighting the existence of inter-organ communication networks.However,the molecular mechanisms underlying both exercise-induced adaptations and organ-to-organ signaling are not fully characterized.Circulating extracellular vesicles(EVs),including exosomes,carry molecules like microRNAs(miRNAs)that may mediate tissue crosstalk.This study aimed to identify specific exercise training-responsive miRNAs that affect skeletal muscle function.Methods miRNA expression profiles of serum-derived EVs were analyzed in healthy young individuals before and after 3 weeks endurance exercise training.Exercise training-responsive miRNAs were then validated for a functional role in cellular metabolic processes in human myotubes.Results We identified several exercise training-responsive miRNAs within exosome-rich EVs in serum,including miR-136-3p.In human myotubes,miR-136-3p enhanced glucose uptake and targeted the nardilysin convertase(NRDC)gene.Transfection of miR-136-3p or silencing of NRDC induced a shift towards glycolytic metabolism in mitochondria and modulated gene expressions related to myogenesis.Pancreatic islets were identified as a potential source of miR-136-3p based on in silico analysis of gene expression and a molecular analysis of conditioned media from isolated pancreatic islets.Conclusion MiR-136-3p is an endurance training-responsive molecular transducer that modulates glucose metabolism and cellular proliferation in myocytes.Associated with EVs,extracellular miR-136-3p may serve as a molecular messenger to communicate islet–skeletal muscle crosstalk after exercise.Extracellular miR-136-3p may serve as a molecular messenger to communicate islet–skeletal muscle crosstalk.Our results highlight a miRNA-mediated mechanism that participates in inter-organ communication to fine tune the metabolic adaptations to exercise. 展开更多
关键词 Extracellular miRNA Endurance training Human skeletal muscle miR-136-3p Nardilycin convertase(NRDC)
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Electrohydrodynamic bioprinting-induced orientation of cell-laden fibrin-alginate hydrogel for highly-aligned skeletal muscle constructs 认领 引用 被引量：1
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作者 Ayiguli Kasimu Zijie Meng +11 位作者 Zhennan Qiu Yabo Zhang Lang Bai Xiao Tan Ziyu Wang Ruosen Zhao Qianxi Gao Hui Zhu Zhanguo Tong Wurikaixi Aiyiti Dichen Li Jiankang He 《International Journal of Extreme Manufacturing》 SCIE EI CAS CSCD 2026年第3期695-714,共20页
Bioprinting provides an unparalleled tool for engineering living tissue constructs that mimic the structural organization of native skeletal muscles.However,it remains a challenge for existing bioprinting strategies t... Bioprinting provides an unparalleled tool for engineering living tissue constructs that mimic the structural organization of native skeletal muscles.However,it remains a challenge for existing bioprinting strategies to recapitulate the highly aligned cellular architectures inside skeletal muscles,primarily due to low printing resolution and limited capability for in situ microenvironmental regulation.Here,we propose to employ the electrical force during the electrohydrodynamic(EHD)bioprinting process to induce the in situ orientation of cell-laden fibrin-alginate hydrogel,which provides nanostructural guidance to the encapsulated cells for the formation of highly aligned skeletal muscle constructs.It was observed that the randomly distributed fibrin protofibril aggregates gradually elongated into uniformly aligned nanofibers at the Taylor cone stage as the applied voltage increased to 3 kV.The oriented fibrin nanofibers further direct in situ cellular alignment along the EHD bioprinting trajectory,facilitating the freeform fabrication of parallelly or circumferentially aligned muscle tissue constructs in vitro.The addition of conductive polymers into the fibrin-alginate hydrogel endows the EHD-bioprinted living constructs with muscle-specific conductivity and cellular organization,which promote myotube differentiation and maturation.The resultant aligned and conductive muscle constructs promoted in situ muscle regeneration and restored lost muscle functions at the defect regions in vivo.The presented EHD bioprinting strategy for fibrin-alginate hydrogel provides a versatile and simple platform to freely fabricate conductive,living tissue constructs with designer cellular alignments. 展开更多
关键词 electrohydrodynamic bioprinting in situ fibrin orientation cell alignment conductive hydrogel muscle tissue engineering
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Exercise preconditioning prevents immobilization-induced skeletal muscle atrophy by activating Prmt1-p38/ATF2-Sesn1 signaling axis in C57BL/6J mice 认领 引用 被引量：1
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作者 Xuege Yang Yuchen Zou +2 位作者 Haoyu Wang Yanmei Niu Li Fu 《Sports Medicine and Health Science》 CAS CSCD 2026年第2期197-209,共13页
Purpose: This study aimed to explore the effects of a 10-week combined exercise regimen on immobilizationinduced muscle atrophy and elucidate the possible function of Protein arginine methyltransferase 1(Prmt1) in thi... Purpose: This study aimed to explore the effects of a 10-week combined exercise regimen on immobilizationinduced muscle atrophy and elucidate the possible function of Protein arginine methyltransferase 1(Prmt1) in this process.Methods: 8-week-old male C57BL/6J mice were carried out combined exercise for 10 weeks. One week before the end of the intervention, mice underwent cast immobilization. Additionally, to investigate the potential mechanism in exercise-induced protection of skeletal muscle, mice in the exercise preconditioning group were administered TC-E-5003(an inhibitor of Prmt1 enzymatic activity). Exercise performance, muscle mass, and the cross-sectional area(CSA) of muscle fibers were analyzed. Besides, Prmt1 and Sestrin1(Sesn1) were either overexpressed or inhibited in C2C12 myotubes to elucidate the underlying mechanism.Results: Exercise preconditioning not only significantly improved muscle mass and motor ability in immobilized mice but also inhibited excessive activation of degradation pathways and enhanced protein synthesis. Importantly, Prmt1 mediated the protective effects of exercise preconditioning on muscle atrophy. Mechanistically,Prmt1 regulated the p38 mitogen-activated protein kinase(p38)/activating transcription factor 2(ATF2)pathway, which modulates Sesn1 expression. Sesn1 acts as a downstream of Prmt1 and ATF2, contributing to the myoblast differentiation and skeletal muscle regeneration through AMP-Activated protein kinase α2(AMPKα2)ranscriptional co-activator PPAR-γ co-activator-1 α(PGC-1α) signaling pathway.Conclusions: Taken together, our results highlighted the effectiveness of exercise preconditioning in preventing muscle atrophy via the Prmt1-Sesn1 pathway. 展开更多
关键词 Prmt1 Skeletal muscle atrophy Immobilization Sesn1 ATF2 PGC-1α
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Resistance exercise alleviates skeletal muscle atrophy through reduction of oxidative stress via Sestrin1 in C57BL/6J mice 认领 引用 被引量：1
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作者 Xuege Yang Jinglin Peng +3 位作者 Yating Huang Sujuan Liu Yanmei Niu Li Fu 《Sports Medicine and Health Science》 CAS CSCD 2026年第1期50-60,共11页
Resistance exercise has been confirmed to be important for maintaining muscle mass and function.However,despite considerable experimental studies,the underlying mechanisms still requires further investigation to be el... Resistance exercise has been confirmed to be important for maintaining muscle mass and function.However,despite considerable experimental studies,the underlying mechanisms still requires further investigation to be elucidated.Sestrin1 is a stress-inducible protein strongly associated with the occurrence and development of skeletal muscle dysfunction.Besides,oxidative stress is believed to be a major pathogenic mechanism in the development of skeletal muscle atrophy,whereas regular exercise training induces the endogenous antioxidative system and protects the body against adverse effects of oxidative stress.Nevertheless,whether Sestrin1 is involved in the amelioration of resistance exercise on muscle atrophy and the role of its antioxidant function in this process remains unknown.Here we show that six-week resistance exercise training significantly improved muscle function,muscle mass,and oxidative damage and maintained the level of Sestrin1 in dexamethasone-treated C57BL/6J mice.Mechanistically,Sestrin1 overexpression rescued protein degradation and oxidative stress in atrophied myotubes.Furthermore,an emerging regulator of cellular defense against toxic and oxidative insults,nuclear factor erythroid2–related factor 2(Nrf2)controls the basal and induced expression of an array of antioxidant response element–dependent genes to regulate the pathophysiological outcomes of oxidant exposure.In this study,we found that Nrf2 is a target of Sestrin1,and Nrf2 nuclear translocation is facilitated by Sestrin1.ML385(an Nrf2 inhibitor)treatment mitigated the regulatory effects of overexpression-Sestrin1.Therefore,Sestrin1 was involved in the process of resistance exercise against skeletal muscle atrophy,which may be closely related to its antioxidant capacity,revealing a potential therapeutic strategy for reducing the loss of skeletal muscle. 展开更多
关键词 Resistance exercise Muscle atrophy Sestrin1 Oxidative stress Nrf2
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Impact of heart failure on skeletal muscle:an overview 认领 引用
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作者 Lucian Batista de Oliveira Marina Baltar de Albuquerque +2 位作者 Amalia Pinheiro Jácome Bezerra Cavalcanti Fábio Moura Francisco Bandeira 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2026年第2期113-120,共8页
Heart failure(HF)is a complex clinical syndrome that promotes high morbidity and multi-systemic damage.Skeletal muscle can be directly affected by HF through a loss of physical capacity and various inflammatory,hormon... Heart failure(HF)is a complex clinical syndrome that promotes high morbidity and multi-systemic damage.Skeletal muscle can be directly affected by HF through a loss of physical capacity and various inflammatory,hormonal,and metabolic mechanisms observed in this cardiac condition,which collectively contribute to a high prevalence of sarcopenia in HF patients.Therefore,the aim of this review was to compile the main recent clinical and epidemiological data on muscle health in HF patients.Nine studies were selected from systematic reviews and clinical trials,which demonstrated a high prevalence of sarcopenia in patients with HF,particularly in males,hospitalized patients,the elderly,and those with HF with reduced ejection fraction.Oxidative stress markers and higher levels of natriuretic peptides were also observed in HF patients who exhibited damaged muscle parameters.Furthermore,the overall deterioration of prognosis in HF was associated with criteria defining sarcopenia,such as low muscle strength and lean mass loss.These findings reinforce the importance of evaluating skeletal muscle in HF patients,which can provide improvements in morbidity and functionality. 展开更多
关键词 natriuretic peptides heart failure muscle health clinical epidemiological data sarcopenia skeletal muscle oxidative stress heart failure hf
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New insights into the skeletal muscle circadian clock in ruminants 认领 引用
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作者 Qiangjun Wang Yuxin Chen +4 位作者 Yale Chen Yinghui Ling Shuai Gao Zijun Zhang Dalong Ren 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2026年第4期1864-1877,共14页
Circadian rhythms are endogenous oscillations with a period of approximately 24 h.They enable organisms to anticipate and adapt to daily environmental changes,such as light and temperature.As the largest metabolic and... Circadian rhythms are endogenous oscillations with a period of approximately 24 h.They enable organisms to anticipate and adapt to daily environmental changes,such as light and temperature.As the largest metabolic and motor organ in the body,skeletal muscle plays a decisive role in determining meat production efficiency in ruminants.Skeletal muscle development is largely governed by the proliferation and myogenic differentiation capacity of skeletal muscle satellite cells(SMSCs).More than 2,300 genes in skeletal muscle exhibit circadian oscillatory expression and are extensively involved in myogenesis,transcriptional regulation,and metabolic processes.The rhythmic expression of these genes is modulated by external factors including the photoperiod,feeding behavior,gut microbiota,and physical activity.Disruption of the endogenous circadian timing system can inhibit SMSC proliferation and myogenic differentiation,thereby impairing normal muscle development.Therefore,this review focuses on key management aspects of ruminant production—such as environmental control,nutritional regulation,and exercise management—and systematically elaborates on how these husbandry strategies may influence SMSC fate by modulating the circadian clock,along with the underlying molecular mechanisms. 展开更多
关键词 Circadian clock Myogenic differentiation Ruminants Satellite cells Skeletal muscle
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Advanced biofabrication techniques of muscle cell-powered biohybrid robots 认领 引用
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作者 Niyou Wang Yipei Yang +10 位作者 Zahra Rezaei María JoséVeana Hernández Kannan Govindaraj Carolina Vazquez Garzon Marina Colin Alan de Jesus Alarcon Rodríguez Alvaro Dario Martinez Blanco Jose Joaquin Velasco Jihyun Lee Jeong-Woo Choi Su Ryon Shin 《International Journal of Extreme Manufacturing》 SCIE EI CAS CSCD 2026年第1期220-268,共49页
Muscle cell-powered biohybrid robots represent a transformative fusion of biological tissue engineering and robotics,offering unprecedented potential for biomedical applications targeted at drug delivery,regenerative ... Muscle cell-powered biohybrid robots represent a transformative fusion of biological tissue engineering and robotics,offering unprecedented potential for biomedical applications targeted at drug delivery,regenerative medicine,bioengineered heart patches,lab-on-a-chip devices,biosensors,and soft surgical tools.This review categorizes the currently available examples and further explores advanced biofabrication techniques that drive the development of biohybrid systems,with a focus on 3D bioprinting,electrospinning,microano patterning,self-assembly,and microfluidic devices.These fabrication strategies facilitate precise cell alignment,enhance electrical and mechanical properties,and enable the seamless integration of biological components with engineered structures.By incorporating both cardiomyocytes and skeletal muscle cells,biohybrid robots achieve controlled actuation,autonomous movement,and adaptability to environmental stimuli.Furthermore,we discuss the latest optimization strategies in biofabrication,addressing key challenges such as scalability,biocompatibility,and functional integration.Biohybrid robots,including swimmers,actuators,and pumps,enable targeted drug delivery,assistive devices,and fluid transport in engineered tissues.Their integration with biological systems advances regenerative medicine,disease modeling,drug screening,and soft robotics.This review provides a comprehensive perspective on the state-of-the-art advancements and potential optimization in the fabrication techniques,paving the way for the next generation of biohybrid robotic systems. 展开更多
关键词 biohybrid robots biofabrication skeletal muscle cell cardiomyocyte bioactuators tissue engineering
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An InDel in the promoter of ribosomal protein S27-like gene regulates skeletal muscle growth in pigs 认领 引用
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作者 Xiaoqin Liu Xinhao Fan +7 位作者 Junyu Yan Longchao Zhang Lixian Wang Honor Calnan Yalan Yang Graham Gardner Rong Zhou Zhonglin Tang 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2026年第3期1114-1124,共11页
Genetic improvement of meat production traits has always been the primary goal of pig breeding.Geographical isolation,natural and artificial selection led to significant differences in the phenotypes of meat productio... Genetic improvement of meat production traits has always been the primary goal of pig breeding.Geographical isolation,natural and artificial selection led to significant differences in the phenotypes of meat production traits between Chinese local pigs and Western commercial pigs.Comparative genomics and transcriptomics analysis provided powerful tools to identify genetic variants and genes associated with skeletal muscle growth.However,the number of available genetic variants and genes are still limited.In this study,a comprehensive comparison of transcriptomes showed that ribosomal protein S27-like(RPS27L)gene was highly expressed in skeletal muscle and up-regulated in Chinese local pigs when compared with Western commercial pigs.Functional analysis revealed that overexpression of RPS27L promoted myoblast proliferation and repressed differentiation in pig skeletal muscle cells.Conversely,the knockdown of RPS27L led to the inhibition of myoblast proliferation and the promotion of differentiation.Notably,a 13-bp insertion-deletion(InDel)mutation was identified within the RPS27L promoter,inserted in Chinese local breeds and predominantly deleted in Western commercial breeds.Luciferase reporter assay suggested this InDel modulated RPS27L expression by influencing transcription factor 3(TCF3)and myogenic differentiation antigen(MYOD)binding to the promoter.Furthermore,a positive correlation was observed between RPS27L expression and backfat thickness.Association studies demonstrated this InDel was significantly associated with the body weight of pigs at the age of 240 d.Together,our results suggested that RPS27L was a regulator of skeletal muscle development and growth,and was a candidate marker for improving meat production traits in pigs.This study not only provided a biomarker for animal breeding,but also was helpful for understanding skeletal muscle development and muscular disease in humans. 展开更多
关键词 pig InDel RPS27L skeletal muscle growth and development
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A high-fat diet rescues muscle atrophy by restoring adiponectin and attenuating systemic inflammation in cachectic mice 认领 引用
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作者 Yida Wang Yannan Guo +5 位作者 Huan Peng Nan Long Qingfei Liu Ying Qiu Xue Li Zhao Wang 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第7期3116-3127,共12页
Cancer cachexia is a multifactorial syndrome characterized by progressive muscle and fat loss,driven by systemic inflammation and metabolic dysfunction.The role of adipose tissue in modulating muscle wasting through e... Cancer cachexia is a multifactorial syndrome characterized by progressive muscle and fat loss,driven by systemic inflammation and metabolic dysfunction.The role of adipose tissue in modulating muscle wasting through endocrine signaling remains underexplored.This study investigates the therapeutic potential of a high-fat diet(HFD)in mitigating muscle atrophy in cancer cachexia through adiponectin signaling.Lewis lung carcinoma(LLC)cells(1.5×106cells per mouse)were subcutaneously implanted in C57BL/6J mice to induce cachexia.Mice were randomized to receive either a standard diet(CD)or an HFD(65%energy from fat)for 21 days post-tumor implantation.Serum and tissue samples were analyzed for inflammatory markers,muscle mass,adiponectin expression,and muscle function using enzyme-linked immunosorbent assay(ELISA),quantitative real-time PCR(qRT-PCR),hematoxylin-eosin(H&E)staining,and functional assays.The HFD did not affect tumor size or energy intake but reduced hepatosplenomegaly(liver:P=0.0282,spleen:P<0.0001)and circulating inflammatory factor levels(tumor necrosis factor alpha(TNFα):22.9%,interleukin 6(IL6):30.4%,interleukin 1 beta(IL1β):33.6%,compared to LLC+CD)in cachectic mice.The HFD attenuated the loss of muscle mass(P=0.0115),functional decline,reduction in myofiber cross-sectional area,and the expression of atrophy-related genes.It also mitigated weight loss(inguinal white adipose tissue(iWAT)mass loss:54%in CD vs.12%in HFD;epididymal white adipose tissue(eWAT)mass loss:49%in CD vs.19%in HFD)and adipocyte atrophy in both iWAT and eWAT,concurrently reducing adipose browning and inflammatory factor expression.Mechanistically,transcriptome analysis of muscle and iWAT implicated adiponectin-related pathways.The HFD enhanced adiponectin expression in iWAT,partially restored circulating adiponectin levels(9.6%,P=0.0220,compared to LLC+CD),and upregulated AdipoR1 expression in muscle.This increased adiponectin expression in adipose tissue appeared to be mediated by peroxisome proliferator-activated receptor gamma(PPARγ)and CCAAT/enhancer-binding protein alpha(C/EBPα).Consequently,gene expression associated with mitochondrial biogenesis,muscle cell regeneration,and fatty acid utilization was activated in muscle tissue.An HFD mitigates fat loss and muscle atrophy in cancer cachexia.It restores adiponectin secretion in adipose tissue and attenuates systemic inflammation.These findings underscore the therapeutic potential of dietary modulation in cachexia and highlight the fat-to-muscle axis as a promising target for future interventions. 展开更多
关键词 Cachexia High-fat diet Adipose wasting Muscle atrophy Adiponectin
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3D genomic alterations during development of skeletal muscle in chicken 认领 引用
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作者 Zhongxian Xu Tao Wang +16 位作者 Wei Zhu Maosen Yang Dong Leng Ziyu Li Jiaman Zhang PengliangLiu Zhoulin Wu Mengnan He Yan Li Hua Kui Xue Bai Bo Zeng Yao Zhang Qing Zhu XiaolingZhao Mingzhou Li Diyan Li 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2026年第1期207-226,共20页
The development of skeletal muscle are complicated processes involving genes responsible for proper muscle morphology,contractility,cell proliferation,differentiation,interactions,migration,and death.The three-dimensi... The development of skeletal muscle are complicated processes involving genes responsible for proper muscle morphology,contractility,cell proliferation,differentiation,interactions,migration,and death.The three-dimensional chromatin architecture of skeletal muscle development has not been studied intensively although dynamic transcriptional regulation during differentiation of muscle cells is one of the most deeply studied processes.The RNA-seq was used to analyze the transcriptome pattern during chicken muscle development across 12 stages.Hi-C was used to build chromatin architectures during four representative stages.Ch IP-seq was conducted to identify enhancers and promoters in these four stages,which are occupied by histone H3K27ac and H3K4me3 peaks.Results show that large-scale genome architecture changes are mostly unidirectional,and coupled by complex on/off dynamic patterns of gene expression.Specifically,we observed 258.30 Mb of the genome undergoing A/B compartment switching.Notable alterations(316.57 Mb)of interaction frequencies within TADs were observed.Substantial aging-associated genes exhibited ascending connectivity with the compartment transition from repressive to active status during muscle development.Some muscle-related gene promoters that interacted with active enhancers during development,and some myopathy/aging-associated genes that were activated in aging muscle were founded.These results provide key insights into skeletal muscle development in vivo,and offer a valuable resource that allows in-depth functional characterization of candidate genes. 展开更多
关键词 skeletal muscle development gene expression chromatin architecture
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Potential molecular mechanisms of ovalbumin in promoting muscle injury repair in mice:insights from transcriptomics and metabolomics 认领 引用
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作者 Yuqing Lei LiPan +6 位作者 Shijun Li Ying Gao Jiaying Huo Lulu Ma Shijian Dong Jijun Wu Shugang Li 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第1期335-350,共16页
Skeletal muscle injuries are prone to induce fatigue,decrease resistance and imbalances in the body.Although ovalbumin(OVA)has such biological effect as promoting tissue development and immunomodulation,its impact on ... Skeletal muscle injuries are prone to induce fatigue,decrease resistance and imbalances in the body.Although ovalbumin(OVA)has such biological effect as promoting tissue development and immunomodulation,its impact on repairing skeletal muscle injuries has been rarely reported.In this study,a mouse model of muscle injury was constructed and found that OVA significantly increased muscle weight,muscle thickness,and exercise capacity in muscle-injured mice.Meanwhile,OVA improved the morphology of muscle tissues by reducing serum levels of urea nitrogen,creatine kinase,and lactate dehydrogenase,as well as decreasing the levels of inflammatory factors interleukin(IL)-1β,tumor necrosis factor α,and IL-6,respectively.In addition,transcriptomic and metabolomic analyses revealed that OVA could enhance muscle tissue morphology by upregulating the phosphatidylinositol 3-kinase-protein kinase B signaling pathway and improving amino acid metabolism through the upregulation of Col11a2,Ccn2,Thbs1,Tnc,Klf2,Bcl2l1,Adh3a1,and Rsad1.The study provided a theoretical foundation for understanding the molecular mechanisms in OVA-aided muscle injury repair. 展开更多
关键词 Transcriptomics Metabolomics Ovalbumin Muscle recovery
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Kaempferol protects against dexamethasone-induced muscle atrophy in mice by increasing PI3K/AKT/mTOR and NRF2/HO-1/KEAP1 signaling pathways:network pharmacology,molecular docking,and experimental validation studies 认领 引用
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作者 Ming Zhang Guofei Chang +6 位作者 Shouzheng Gao Jiuying Wei Minmin Chen Ling Song Juan Lu Jun Sheng Xiao Ma 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第2期851-868,共18页
Muscle atrophy can be induced by high doses or prolonged use of glucocorticoids.Kaempferol(Kae)is a naturally occurring flavonoid with a variety of biological activities and the effect of Kae on dexamethasone(Dex)indu... Muscle atrophy can be induced by high doses or prolonged use of glucocorticoids.Kaempferol(Kae)is a naturally occurring flavonoid with a variety of biological activities and the effect of Kae on dexamethasone(Dex)induced muscle atrophy in animals has not been elucidated.To explore this issue,the present experiments used a computationally assisted drug design scheme combining network pharmacology,molecular docking and in vivo experiments to investigate the mechanism of Kae against muscle atrophy.Network pharmacological analyses revealed 275 potential targets for Kae and 12294 potential targets for muscle atrophy,with a total of 228 crosstargets for Kae and muscle atrophy.GO and KEGG analyses were performed based on the protein-protein interaction(PPI)network of muscle atrophy and Kae component targets.The GO results showed that the biological processes were mainly related to the metabolic process of reactive oxygen species,and the response to oxidative stress;the cellular components were mainly focused on membrane microdomains,and membrane regions;the molecular functions mainly worked on phosphatase binding;and the KEGG pathway enrichment analyses identified the pathways of interaction between Kae and muscle atrophy.Finally,as verified by in vivo experiments,Kae may reduce the onset of muscle atrophy by activating the PI3K/AKT/m TOR/signalling pathway,inhibiting Foxo1/Foxo3 activity,and inhibiting downstream production of the ubiquitination 3 ligases Atrogin1 and Mu RF1;Kae also promotes the expression of NRF2/HO-1/KEAP1 signalling pathway,enhances muscle antioxidant capacity,inhibits the release of COX-2 and TNF-αinflammatory factors,and reduces the damage caused by oxidative stress and inflammatory factors to muscles.Therefore,there may be a synergistic effect of PI3K/AKT/m TOR and NRF2/HO-1/KEAP1 in Kae working together to prevent muscle atrophy.The binding energy and stability of Kae to potential targets were examined by molecular docking and molecular dynamics simulations,implying that Kae could be used for the prevention and treatment of muscle atrophy in patients. 展开更多
关键词 Kaempferol Dexamethasone Muscle atrophy PI3K/AKT/mTOR signaling pathway NRF2/HO-1/KEAP1 signaling pathway
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Reevaluating the role of skeletal muscle in amyotrophic lateral sclerosis pathogenesis:Insights from muscle-derived factors 认领 引用
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作者 Pablo Martinez Brigitte van Zundert Fernando J.Bustos 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第7期2944-2945,共2页
Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease marked by motor neuron(MN)degeneration,neuromuscular junction disruption,and muscle atrophy,ultimately leading to paralysis and death.Despit... Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease marked by motor neuron(MN)degeneration,neuromuscular junction disruption,and muscle atrophy,ultimately leading to paralysis and death.Despite extensive research,no effective treatment exists,highlighting the need to elucidate mechanisms driving ALS pathogenesis.About 90%of ALS cases are sporadic ALS and lack a clear genetic cause;the remaining 10%are familial ALS,associated with mutations in over 25 genes.The most common mutations are in superoxide dismutase 1(SOD1)and C9ORF72,with rarer variants in FUS,TARDBP,TBK1,and VCP. 展开更多
关键词 amyotrophic lateral sclerosis als neurodegenerative disease elucidate mechanisms neuromuscular junction amyotrophic lateral sclerosis motor neuron muscle atrophyultimately junction disruptionand
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