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Is salvage surgery necessary for non-R0 endoscopic resection of small rectal neuroendocrine tumors? 认领 引用
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作者 Shi-Yong Lin Ze-Hua Li +2 位作者 Guo-Liang Xu Jun Weng Kun-Hao Bai 《World Journal of Gastrointestinal Oncology》 SCIE 2026年第6期216-222,共7页
BACKGROUND The rate of R0 endoscopic resection for small rectal neuroendocrine tumors(r-NETs)is nearly 90%.However,there is still controversy about subsequent treatment options for patients with non-R0 endoscopically ... BACKGROUND The rate of R0 endoscopic resection for small rectal neuroendocrine tumors(r-NETs)is nearly 90%.However,there is still controversy about subsequent treatment options for patients with non-R0 endoscopically resected r-NETs.AIM To investigate the necessity of salvage surgery for non-R0 endoscopic resection of small r-NETs.METHODS A single-center retrospective study.Thirty-eight patients with r-NETs who underwent non-R0 endoscopic resection at Sun Yat-sen University Cancer Centre between 2007 and 2023 were retrospectively analyzed.RESULTS Thirty patients underwent salvage surgery while 8 received follow-up only.Among those 30 patients with salvage surgery,12 cases underwent salvage endoscopic submucosal dissection,while 16 underwent salvage transanal endoscopic microsurgery,2 underwent salvage radical resection(low anterior resection).Postoperative pathology following salvage surgery indicated an absence of tumor cells in all 30 patients.Among the 8 patients who received follow-up only,3 received endoscopic biopsy of the scar during follow-up.Pathological evaluation of the biopsy specimens also showed no residual tumor cells.All 38 patients underwent regular endoscopic and imaging follow-up with an average follow-up duration of 46.4±14.8 months.No evidence of local tumor recurrence or distant metastasis was observed.CONCLUSION These findings suggest that salvage surgery may not be essential for patients with non-R0 endoscopically resected r-NETs,with regular follow-up being a safe alternative. 展开更多
关键词 Rectal neuroendocrine tumors Endoscopic resection Non-R0 resection Salvage surgery Follow-up
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Letter to the Editor:Deep margin positivity in small rectal neuroendocrine tumors-pathological insights for post-endoscopic submucosal dissection management 认领 引用
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作者 Ling-Feng Zou Yan Luo Cheng-Long Wang 《World Journal of Clinical Oncology》 2026年第5期225-228,共4页
The management of small rectal neuroendocrine tumors(NETs)with positive vertical margins after endoscopic resection remains controversial.In light of the recent study by Qiao et al published in World Journal of Clinic... The management of small rectal neuroendocrine tumors(NETs)with positive vertical margins after endoscopic resection remains controversial.In light of the recent study by Qiao et al published in World Journal of Clinical Oncology,which reported excellent oncologic outcomes following both endoscopic submucosal dissection(ESD)and hybrid ESD for stage 1 rectal NETs,we provide a pathology-centered reinterpretation of margin positivity.Despite multiple non-R0 resections,predominantly due to positive vertical margins,no patients developed local recurrence or metastasis.From a histopathological perspective,apparent margin involvement is frequently attributable to technical artifacts such as thermal injury,tissue distortion,tangential sectioning,or specimen fragmentation rather than true residual viable tumor.Moreover,the intrinsic biological indolence of small,well-differentiated(G1)rectal NETs further explains the low risk of recurrence.Together,these observations support a risk-stratified,surveillance-oriented management strategy and underscore the importance of nuanced pathological interpretation to avoid unnecessary salvage surgery while maintaining oncologic safety. 展开更多
关键词 Rectal neuroendocrine tumor Endoscopic submucosal dissection Positive vertical margin Non-R0 resection Pathologic margin assessment
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术后辅助放疗在R0切除的Ⅰ~Ⅱ期非小细胞肺癌中的地位——基于美国国家癌症数据库分析 认领 引用 被引量：1
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作者 熊乐 刘安文 刘克军 《循证医学》 2020年第6期329-332,共4页
1文献来源Pezzi TA,Mohamed ASR,Fuller CD,et al.Radiation therapy is independently associated with worse survival after R0-resection for stageⅠ~Ⅱnon-small cell lung cancer:An analysis of the National Cancer Data Base[... 1文献来源Pezzi TA,Mohamed ASR,Fuller CD,et al.Radiation therapy is independently associated with worse survival after R0-resection for stageⅠ~Ⅱnon-small cell lung cancer:An analysis of the National Cancer Data Base[J].Ann Surg Oncol,2017,24(5):1419-1427.2证据水平2a。3背景1998年发表的一篇针对肺癌术后放射治疗的荟萃分析显示,Ⅰ~Ⅱ期手术切除的非小细胞肺癌(non-small cell lung cancer,NSCLC)患者接受术后放射治疗(postoperative radiotherapy,PORT)与更差的生存预后相关,但考虑与当时落后的放疗仪器及技术也有一定关系。已有利用美国国家癌症数据库(National Cancer Data Base,NCDB)的真实世界研究发现pN2的NSCLC患者行PORT能够获得生存获益,因此,本文旨在运用该数据库分析早期(Ⅰ~Ⅱ期)NSCLC行PORT获益情况。随着放疗仪器及技术改进后,R0切除的Ⅰ~Ⅱ期NSCLC行PORT与预后关系尚未可知。 展开更多
关键词 非小细胞肺癌 R0切除 术后放疗
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关于R_0代数结构的研究 认领 引用 被引量：1
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作者 袁庆生 《西安工业学院学报》 2005年第5期492-494,共3页
对R0代数作进一步研究,证明了有限的非全序R0代数至少存在两个不同的分子和原子,引入并讨论了R0代数中界元的性质,得到了非全序R0代数的一些蕴涵性质,给出了元素个数最少的含中界元的非全序R0代数的例子,从而确定了含中界元的非全序R0... 对R0代数作进一步研究,证明了有限的非全序R0代数至少存在两个不同的分子和原子,引入并讨论了R0代数中界元的性质,得到了非全序R0代数的一些蕴涵性质,给出了元素个数最少的含中界元的非全序R0代数的例子,从而确定了含中界元的非全序R0代数的存在性. 展开更多
关键词 R0代数 非全序 中界元 模糊逻辑
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