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Decoding the glycocode:From structural diversity to engineering rules in microbial surface polysaccharides 认领 引用
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作者 Zhao-Xi Liu Min Chen 《Life Research》 2026年第3期1-3,共3页
Microbial surface glycans,capsular polysaccharides(CPS),O-antigens,lipooligosaccharides and glycoproteins,sit at the interface of host-microbe interactions.Recent technical and conceptual improvements have moved the f... Microbial surface glycans,capsular polysaccharides(CPS),O-antigens,lipooligosaccharides and glycoproteins,sit at the interface of host-microbe interactions.Recent technical and conceptual improvements have moved the field beyond descriptive identification toward a predictive glycobiology fueled by computation and simulation[1]:we can now visualize glycan architecture[2],synthesize defined glycoforms at scale[3],and engineer bacterial surfaces to test causality in host responses[4].These developments mark a conceptual shift in microbial glycobiology:microbial glycans are no longer viewed merely as taxonomic markers but are increasingly recognized as programmable biological information.In this context,Figure 1 outlines the comprehensive landscape of microbial glycan research,spanning from structural visualization and synthetic engineering to translational applications,thereby highlighting key future directions in the field. 展开更多
关键词 capsular polysaccharides structural diversity microbial surface polysaccharides O antigens test causality host responses engineering rules microbial surface glycanscapsular polysaccharides cps o antigenslipooligosaccharides visualize glycan architecture synthesize defined glycoforms
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Phellodendron amurense Rupr.Polysaccharides protects against diabetic nephropathy via alteration of PI3K/GSK-3β/Nrf2/TGF-β/Smad signaling pathway and gut microbiota 认领 引用 被引量：1
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作者 Mei Mei Huawei Sun +3 位作者 Kai Zhang Feng Zhang Shiqing Sun Yu Zhang 《Natural Products and Bioprospecting》 CSCD 2026年第1期212-229,共18页
In this study,a diabetic nephropathy(DN)rat model was established using 2%Streptozocin(STZ)solution,and an in vitro DN model was constructed by stimulating HK-2 cells with 30 mM glucose to investigate the mecha-nism o... In this study,a diabetic nephropathy(DN)rat model was established using 2%Streptozocin(STZ)solution,and an in vitro DN model was constructed by stimulating HK-2 cells with 30 mM glucose to investigate the mecha-nism of Phellodendron amurense Rupr.Polysaccharides(PAP)in ameliorating DN.Results demonstrated that PAP,a neu-tral homogeneous polysaccharide with molecular weight of 1.98 × 105 Da composed of Rha,GalA,Gal,and D-Xyl,exerted renal protective effects through multiple pathways.It enhanced renal antioxidant capacity and alleviated oxidative damage in DN by upregulating PI3K/AKT pathway-related protein expression.Simultaneously,PAP acti-vated theTGF-β/Smad pathway via Nrf2 to mitigate renal fibrosis symptoms in DN,while inhibiting cellular apoptosis.Furthermore,PAP suppressed renal inflammation through gut microbiota reduction,thereby protecting against renal injury in DN rats.This study reveals that PAP alleviates DN symptoms by modulating gut microbiota,enhancing anti-oxidant and anti-fibrotic capacities,and inhibiting apoptotic pathways,comprehensively elucidating its multifaceted therapeutic mechanisms against DN. 展开更多
关键词 Phellodendron amurense Rupr.Polysaccharides Diabetic nephropathy Gut microbiota
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Laetiporus sulphureus polysaccharides ameliorate chronic alcoholic liver disease by activating p62/Nrf2,AMPK pathways and reshaping gut microbiota 认领 引用
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作者 Huajie Zhao Liang Liu +6 位作者 Ningning Liu Baoguo Deng Min Li Duan Li Le Jia Ge Wang Fan Yang 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第3期1323-1342,共20页
One novel enzymatic-extractable polysaccharide(ES1)from fruiting bodies of Laetiporus sulphureus was obtained by isolation and purification using a DEAE Seplife FF chromatographic column and a Sephacryl S-400HR column... One novel enzymatic-extractable polysaccharide(ES1)from fruiting bodies of Laetiporus sulphureus was obtained by isolation and purification using a DEAE Seplife FF chromatographic column and a Sephacryl S-400HR column.The hepatoprotective ability of ES1 against chronic alcoholic liver disease(ALD)and its underlying mechanism were explored.The results indicated that ES1 could alleviate liver damage in ALD mice by activating sequestosome-1uclear factor E2-related factor 2(P62/Nrf2)pathway to increase antioxidant enzyme activities against oxidative stress,regulating adenosine monophosphate-activated protein kinase(AMPK)pathway to promote fatty acid oxidation and inhibit cholesterol synthesis against lipid metabolism disorders,and improving gut microbiota(increasing the relative abundances of Ligilactobacillus and Akkermansia,and reducing the relative abundances of Enterococcus,Romboutsia,Allobaculum,Coriobacteriaceae_UCG-002,Dubosiella and Faecalibaculum)against intestinal barrier dysfunction.Meantime,structural analysis showed that ES1 with molecular weight of 25.79 kDa was composed ofα-DManp-(1→,→2,6)-α-D-Galp-(1→,→6)-α-D-Galp-(1→,→3)-α-L-Fucp-(1→,andα-D-Glcp-(1→,and its structure was also inferred.Therefore,these data support the application of ES1 as a potential functional food or drug for treating ALD. 展开更多
关键词 Laetiporus sulphureus polysaccharides Alcoholic liver disease Lipid metabolism Oxidative stress Gut microbiota
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A review of food-derived polysaccharides in intervening in disorders of glucose and lipid metabolism:an inter-organ crosstalk between gut,liver,adipose tissue,and nervous system 认领 引用
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作者 Weijun Cui Xiangyang Zhu +5 位作者 Chunli Hu Xueping Li Xinling Song Shiwei Yu Dapeng Li Chen Zhang 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第2期508-519,共12页
The diseases caused by disorders in glucose and lipid metabolism have become one of the prevalent health issues,posing a serious threat to human health.Previous studies have shown that food-derived polysaccharides hav... The diseases caused by disorders in glucose and lipid metabolism have become one of the prevalent health issues,posing a serious threat to human health.Previous studies have shown that food-derived polysaccharides have a certain intervention effect on disorders in glucose and lipid metabolism.This article reviewed the structure-function relationship of food-derived polysaccharides and elucidated their role in regulating glucose and lipid metabolism.Some new evidence suggests that secondary metabolites such as short-chain fatty acids,secondary bile acids,and lipopolysaccharide act as signaling molecules,activating pathways related to glucose and lipid metabolism,alleviating oxidative stress,inhibiting inflammation in the body,and regulating the homeostasis of glucose and lipid metabolism.These results indicated that food-derived polysaccharides have a positive impact on the regulation of glucose and lipid metabolism by improving the gut microbiota environment.On the other hand,gut microbiota disturbance can affect the host’s health through the gut-liver,gut-brain and gut-adipose tissue axes.Therefore,it is speculated that food-derived polysaccharides may intervene in glucose and lipid metabolism through the inter-organ crosstalk between gut,liver,adipose tissue,and nervous system.This essay provides a theoretical basis for the development and utilization of food-derived polysaccharides as prebiotics in intervening disorders in glucose and lipid metabolism. 展开更多
关键词 Food-derived polysaccharides Glucose and lipid metabolism Anti-inflammatory Intestinal flora
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Agrocybe cylindracea polysaccharides repair the intestinal mucosal barrier in DSS-induced colitis by modulating the gut microbiota-macrophage axis 认领 引用
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作者 Zaoxuan Wu Shujian Wu +6 位作者 Xiuying Liu Shuze Chen Senbao Xu Yunying Gong Qiujuan Ye Xuefeng Gao Ye Chen 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第4期1702-1717,共16页
The Agrocybe cylindracea polysaccharides(ACP)have been shown to possess various health benefits.However,the anti-inflammatory effects of ACP and the mechanisms underlying these effects remain poorly understood.In this... The Agrocybe cylindracea polysaccharides(ACP)have been shown to possess various health benefits.However,the anti-inflammatory effects of ACP and the mechanisms underlying these effects remain poorly understood.In this study,we delved into the potential of ACP in mitigating colitis induced by dextrose sodium sulfate(DSS)in C57BL/6J mice and explored the associated mechanisms.ACP demonstrated notable antiinflammatory effects in the intestines,as evidenced by the restoration of various indicators such as increased body weight and colon length,decreased disease activity index(DAI)score,and alleviation of pathological damage in the colon.Additionally,ACP upregulated the expression of ZO-1,Occludin,and Muc2,suggesting a restoration of the mechanical and mucus barriers of the intestinal mucosa.Furthermore,ACP facilitated the polarization of M2 macrophages and preserved intestinal immune balance.The impact of ACP on the biological barrier was further scrutinized.ACP ameliorated disruptions in the gut microbiota,particularly by enhancing the relative abundance of bacteria that produce short-chain fatty acids(Anaerostipes,Romboutsia,and Butyricicoccus).Remarkably,the ameliorative effects of ACP on colitis were compromised upon the removal of the microbial community,but were restored post fecal microbiota transplantation(FMT),indicating that the efficacy of ACP in alleviating colitis is dependent on the gut microbiota.Intriguingly,the regulatory influence of ACP on macrophages also hinged on the gut microbiota.In essence,ACP exhibits the potential to modulate the composition of the gut microbiota,fostering the growth of beneficial bacteria,which in turn promotes the polarization of colonic M2 macrophages and facilitates the repair of the intestinal mucosal barrier in DSS-induced colitis.These findings underscore the capacity of ACP to enhance the intestinal mucosal barrier and ameliorate colitis by modulating the gut microbiota-macrophage axis,suggesting that ACP could serve as a functional food supplement for preserving intestinal homeostasis and preventing colitis. 展开更多
关键词 Agrocybe cylindracea polysaccharides Ulcerative colitis Gut microbiota M2 macrophage polarization Intestinal mucosal barrier
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Polygonatum sibiricum Red.and its polysaccharides in cognitive improvement:Pharmacological mechanisms and therapeutic potential 认领 引用
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作者 Cong Lu Xiangfei Zhang +3 位作者 Lifang Chen Jing Sun Bei Fan Fengzhong Wang 《Journal of Traditional Chinese Medical Sciences》 CAS CSCD 2026年第2期139-149,共11页
Cognitive impairment is a growing public health concern associated with aging,neurodegenerative diseases,and chronic stress.Polygonatum sibiricum Red.(P.sibiricum,Huang Jing),a traditional Chinese medicinal herb,is us... Cognitive impairment is a growing public health concern associated with aging,neurodegenerative diseases,and chronic stress.Polygonatum sibiricum Red.(P.sibiricum,Huang Jing),a traditional Chinese medicinal herb,is used to reinforce qi,strengthen the spleen,and nourish yin.Recent studies have suggested that P.sibiricum polysaccharides(PSP),its major bioactive constituents,exert neuroprotective effects through antioxidant and anti-inflammatory actions,modulation of the gut-brain axis,and improvement of synaptic plasticity.This review summarizes recent advances in the pharmacological activities of P.sibiricum and PSP related to cognitive improvement,highlights findings from behavioral,cellular,and molecular studies,and examines the clinical evidence supporting their therapeutic potential.Understanding the mechanism of action of P.sibiricum offers new insights into its potential development as a functional food or complementary therapeutic agent for cognitive decline. 展开更多
关键词 Polygonati rhizoma Polysaccharides Medicine and food homology Cognitive impairment Neuroprotection
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Rauvolfia verticillata-derived pectic polysaccharides alleviate ulcerative colitis via regulating macrophage polarization and inhibiting the JAK2/STAT3-NOS2 pathway 认领 引用
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作者 Fan Jiang Ning Liu +2 位作者 Hai-Dong Wu Xin-Pu Miao Lin Miao 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2026年第4期160-172,共13页
Objective:To investigate the effect of pectic polysaccharides isolated from Rauvolfia verticillata on ulcerative colitis and its underlying mechanisms.Methods:Pectic polysaccharides were characterized using high-perfo... Objective:To investigate the effect of pectic polysaccharides isolated from Rauvolfia verticillata on ulcerative colitis and its underlying mechanisms.Methods:Pectic polysaccharides were characterized using high-performance liquid chromatography with 1-phenyl-3-methyl-5-pyrazolone pre-column derivatization,phenol-sulfuric acid assay,and gel permeation chromatography.HT-29 cells were stimulated with lipopolysaccharide and then treated with pectic polysaccharides;conditioned medium was applied to THP-1-derived macrophages to assess cell viability and polarization,while tight junction protein expression was analyzed in HT-29 cells.Furthermore,a mouse model of dextran sulfate sodium-induced colitis was treated with oral pectic polysaccharides or NOS2 overexpression.Body weight,disease activity index,colon length,histopathology,and the protein expression related to the JAK2/STAT3-NOS2 signaling were evaluated.Results:The pectic polysaccharide was characterized as an acidic pectic polysaccharide,primarily composed of galacturonic acid and various neutral sugars,with a narrow molecular weight distribution and high purity.Pectic polysaccharides significantly enhanced THP-1 macrophage viability,promoted M1 to M2 polarization,and upregulated the expression of epithelial tight junction proteins.In addition,pectic polysaccharide treatment attenuated body weight loss,lowered disease activity index scores and improved colon histology in mice with dextran sulfate sodium-induced colitis.It also reduced JAK2/STAT3 phosphorylation and NOS2 expression,and increased the expression of tight junction proteins(ZO-1,occludin,and claudin-1).Conclusions:Pectic polysaccharides attenuate ulcerative colitis by increasing M2-related macrophage markers,inhibiting the JAK2/STAT3-NOS2 signaling,and enhancing epithelial barrier-related protein expression.These findings support pectic polysaccharides as a natural candidate for the treatment of ulcerative colitis. 展开更多
关键词 Rauvolfia-derived polysaccharides Ulcerative colitis Macrophage polarization JAK2/STAT3-NOS2 signaling Epithelial barrier
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Dissolved acidic polysaccharides and chromophoric dissolved organic matter derived from macrophytes:links and implications for carbon cycling 认领 引用
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作者 Qi HUANG Chunxia HUANG +1 位作者 Lizhen LIU Dongyu LI 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2026年第3期1099-1115,共17页
Dissolved acidic polysaccharides(dAPS)and chromophoric dissolved organic matter(CDOM)are both present in aquatic environments and contribute significantly to the dissolved organic carbon pool,whereas the dAPS released... Dissolved acidic polysaccharides(dAPS)and chromophoric dissolved organic matter(CDOM)are both present in aquatic environments and contribute significantly to the dissolved organic carbon pool,whereas the dAPS released from different typical macrophytes and their possible link with CDOM remain uncertain.We conducted an experiment to investigate the changes in dAPS and CDOM derived from five aquatic macrophytes(including two floating and three submerged macrophytes)in the Poyang Lake Nanji wetlands.Macrophytes released dAPS rapidly during the first 4 or 7 d,showing that the production of dAPS from macrophytes was rapid.The floating macrophytes released much more dAPS,CDOM(a(254)),CDOM fluorescence components and dissolved organic carbon(DOC)than submerged macrophytes;however,submerged macrophyte-derived dAPS contributed more to DOC.Generally,macrophyte-derived dAPS accounted for about 10.9% of the released DOC.Spearman's correlations and linear(mixed)model analysis demonstrated that macrophyte-derived d APS were significantly associated with the quantity of released CDOM,and the relationship was dependent on the species.These results will help to better understand the characteristics of DOM in natural waters and associated environmental implications. 展开更多
关键词 dissolved acidic polysaccharides(dAPS) chromophoric dissolved organic matter(CDOM) aquatic plant decomposition dissolved organic carbon(DOC)
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An overview of the advantageous effects and underlying mechanisms of natural polysaccharides in inflammatory bowel disease 认领 引用
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作者 Yating Shao Bo Li +6 位作者 Yongfang Wang Chuanjie Zhou Yunlong Qiao Xinglishang He Shengqiang Tong Guiyuan Lv Suhong Chen 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2026年第1期45-58,共14页
Inflammatory bowel disease(IBD),which includes Crohn’s disease(CD)and ulcerative colitis(UC),is a chronic inflammatory condition affecting the gastrointestinal tract.The global incidence and prevalence of IBD continu... Inflammatory bowel disease(IBD),which includes Crohn’s disease(CD)and ulcerative colitis(UC),is a chronic inflammatory condition affecting the gastrointestinal tract.The global incidence and prevalence of IBD continue to increase.While multiple clinical treatments exist,conventional therapies frequently present limitations and adverse effects.Natural polysaccharides(PSs)have emerged as a significant focus of research interest due to their therapeutic potential and applications in functional foods and health products.This review synthesizes current understanding of IBD pathophysiology and the mechanisms by which natural PSs counter IBD,including their capacity to restore immune homeostasis and intestinal barrier function,modulate gut microbiota and metabolites,reduce oxidative stress,and address irregularities in autophagy and endoplasmic reticulum stress(ERS).The review examines the structure-activity relationships of PSs demonstrating anti-IBD effects and identifies promising therapeutic products.The discussion encompasses pharmacokinetics,safety evaluations,and clinical applications of these compounds.This comprehensive review establishes a theoretical foundation for developing natural PS-based therapeutic approaches for IBD management. 展开更多
关键词 Natural polysaccharides Inflammatory bowel disease Pathogenesis Therapeutic effect Research progress
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Evaluation of the therapeutic significance of Glehniae Radix polysaccharides on the ulcerative colitis through DSS-induced rat model 认领 引用
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作者 Jie Liu Xufang Geng +10 位作者 Yuxin Yang Jiao Xu Haoran Feng Tianshuo Zhang Guangzhao Zhou Man Wang Changshun Wang Dongsheng Jia Yuting Chen Bin Cong Ding Zhao 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第1期292-305,共14页
Glehniae Radix has a wide range of pharmaceutical applications,and research on its main components has mainly focused on coumarins,alkaloids,lignans,and flavonoids,while neglecting the research on polysaccharides.Lite... Glehniae Radix has a wide range of pharmaceutical applications,and research on its main components has mainly focused on coumarins,alkaloids,lignans,and flavonoids,while neglecting the research on polysaccharides.Literature reports and our previous studies have shown that polysaccharides have certain therapeutic significance in immune regulation,antioxidant,anti-inflammatory and other aspects.Herein,the rat model of ulcerative colitis(UC)was established to evaluate the anti-inflammatory efficacy of the prepared Glehniae Radix polysaccharide(GLP)from the perspectives of inflammatory factors,intestinal tissue morphology,and microflora changes.The polysaccharides are mainly composed of galacturonic acid,rhamnose,glucose,galactose,and arabinose in molar ratios of 1.4:9.2:33.3:2.5:2.9,and GLP could downregulate the expression pro-inflammatory factors(interleukin 6,tumor necrosis factorα,and interferonγ)and significantly upregulate the expression of antiinflammatory factor(interleukin 10).In addition,Glehniae Radix aqueous extract(GLA),GLP with low dosage and GLP with high dosage(GLPH)could increase the number of goblet cells,enhance the integrity of crypt structure,and reverse the status of inflammatory infiltrating cells.Moreover,GLA and GLPH could upregulate Lactobacillus and Lachnoclostridium in UC rats,and appropriately downregulate Lachnospiraceae_NK4A136_group,thereby optimizing the proportion of bacterial flora and improving the intestinal microbial environment.Our findings not only be valuable as theoretical materials for the further clinical applications of GLP,but the identified biomarkers and metabolic pathways also provide new clues for the diagnosis of UC. 展开更多
关键词 Glehniae Radix Polysaccharides Ulcerative colitis Gut microbiota Untargeted metabolomics
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Structural evolution, chemical and antioxidant properties of pectic polysaccharides from sesame hull roasted at various temperatures 认领 引用
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作者 Jinyuan Hu Xu Fang +6 位作者 Huixian Guo Rui Wang Wenting Yin Xiaoshuang Cai Huamin Liu Xinliang Zhu Xuede Wang 《Grain & Oil Science and Technology》 EI CAS 2026年第1期21-29,共9页
Roasting constitutes a critical stage in sesame oil production,where the thermal degradation of pectic polysaccharide initiates fundamental chemical transformations including caramelization,Maillard processes,lipid ox... Roasting constitutes a critical stage in sesame oil production,where the thermal degradation of pectic polysaccharide initiates fundamental chemical transformations including caramelization,Maillard processes,lipid oxidation and Strecker degradation.This study systematically examines the structural,chemical and oil antioxidant capacity of sesame hull-derived pectic polysaccharides(URA and URB)under 160–220℃,and their impacts on sesame oil oxidative stability.The results demonstrate temperature-dependent molecular restructuring of URA and URB with molecular weights increasing proportionally and reduced total yields by 42.73%until 220℃.Furfural and organic acids were identified as primary pyrolysis products,accompanied by volatile aromatic compounds including furans,benzenes,and phenols.Sesame oil with the mixture of URA and URB(HSO-URA/B)exhibited optimal thermal antioxidant performance,demonstrating improved sesame oil oxidative stability as evidenced by peroxide value(0.07–0.81 g/100 g)and oxidative stability index(22.6 h).This work provides a scientific foundation for optimizing sesame oil quality while transforming hull byproducts into valueadded food ingredients. 展开更多
关键词 Sesame hull Pectic polysaccharides Antioxidant capacity Roasting Degradation
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Polysaccharides from large leaf yellow tea activates the LXRα-ABCA1/ABCG1 pathway to ameliorate type 2 diabetes by regulating gut microbiota 认领 引用
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作者 Hao Chen Xinxin Pei +7 位作者 Zhuang Wang Jielin Chen Kaili Xuan Lei Gong Xinyu Zhou Yijun Wang Yuzhe Huang Yan Chen 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第4期1674-1687,共14页
Type 2 diabetes mellitus(T2DM)is a multifaceted metabolic condition characterized by chronic hyperglycemia(elevated blood sugar levels)and insulin resistance(IR).We have isolated a new homogeneous polysaccharide,LYTP-... Type 2 diabetes mellitus(T2DM)is a multifaceted metabolic condition characterized by chronic hyperglycemia(elevated blood sugar levels)and insulin resistance(IR).We have isolated a new homogeneous polysaccharide,LYTP-3(7.22×10~5 Da),with anti-diabetic activity,from large leaf yellow tea(LYT)by biological activityguided sequential separation and activity evaluation.Using a T2DM mouse model,we demonstrate that oral administration of LYTP-3 could reduce blood lipid levels,alleviate hyperglycemia and glucose tolerance,and inhibit IR.LYTP-3 ameliorated T2DM treatment by activating the liver X receptor alpha(LXRα)-ATPbinding cassette(ABC)transporter(LXRα-ABCA1/ABCG1)signaling pathway,which is regulated by the gut microbiota.The strain Lachnospiraceae bacterium A4 is potentially the key to this improvement.Additionally,we have solved the molecular structure of LYTP-3 using nuclear magnetic resonance(NMR),and methylation analyses.The main backbone of LYTP-3 consists of 1,2,4-α-L-Rhap,1,4-α-D-Galp,1,6-α-D-Glcp,with branches of 1,4-β-D-Galp,1,6-β-D-Galp A,1,3,6-β-D-Manp,1,2-α-L-Rhap,T-β-Manp,and T-β-Galp.The findings of this study suggest that LYTP-3 may serve as a potential gut microbiota modulator in the treatment of T2DM. 展开更多
关键词 Lachnospiraceae bacterium LXRα-ABCA1/ABCG1 signaling pathway Type 2 diabetes mellitus Large leaf yellow tea polysaccharide
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Lycium Barbarum Polysaccharides Upregulate Trx2 in Schwann Cells through ESR1 to Repair Sciatic Nerve Injury in Rats 认领 引用
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作者 Guoxu Ma Yonglu Huang +7 位作者 Fan Gong Jianke Wu Yi Ding Ziyang Zhang Xiaoliang Li Jian Gao Tingting Dang Bowen Zhang 《BIOCELL》 SCIE 2026年第6期124-142,共19页
Objectives:Sciatic nerve injury(SNI)impairs quality of life,and Lycium barbarum polysaccharides(LBP)may exert therapeutic effects via regulating Schwann cell(SC)mitochondrial stability,though the mechanism remains unc... Objectives:Sciatic nerve injury(SNI)impairs quality of life,and Lycium barbarum polysaccharides(LBP)may exert therapeutic effects via regulating Schwann cell(SC)mitochondrial stability,though the mechanism remains unclear.The study aimed to elucidate the therapeutic mechanisms of LBP in mitigating sciatic nerve injury by protecting Schwann cells via the estrogen receptor 1(ESR1)hioredoxin 2(Trx2)pathway.Methods:An in vitro SNI model was established by inducing RSC96 cells with H2O2.Cell counting kit-8(CCK8)assay,enzyme-linked immunosorbent assay(ELISA),Western blot,reactive oxygen species(ROS)and adenosine triphosphate(ATP)quantification,and mitochondrial membrane potential(MMP)detection were used to evaluate cellular functions and molecular changes.Network pharmacology and molecular docking were employed to predict potential targets of LBP.Chromatin immunoprecipitation(ChIP)assays verified the interaction between ESR1 and Trx2,and ESR1 was knocked down in SCs to confirm the regulatory pathway.Additionally,in vivo validation was performed using a rat SNI model.Results:LBP intervention significantly reduced H2O2-induced mitochondrial dysfunction,inflammation,and oxidative stress in RSC96 cells(p<0.05).It also regulated the expression of apoptosis-related proteins,Trx2,and mitochondrial apoptosis-inducing factor(AIF;p<0.001).Network pharmacology and molecular docking identified ESR1 as a key target of LBP,and ChIP assays confirmed that ESR1 promoted Trx2 transcription.Moreover,LBP enhanced SC proliferation(OD450 at day 5=1.25-fold;colony formation=1.85-fold),increased MMP and ATP levels(MMP=2.25-fold;ATP=1.75-fold),inhibited inflammation,and reduced apoptosis(p<0.001),while ESR1 knockdown abrogated these effects(p<0.05).In rat SNI models,LBP effectively alleviated nerve injury(p<0.001).Conclusion:LBP may modulate Trx2 via ESR1 for the purpose of restoring the dysfunction of SCs induced by H2O2.This potentially offers a new strategy for the therapy of SNI. 展开更多
关键词 Lycium barbarum polysaccharide(LBP) sciatic nerve injury(SNI) Schwann cells(SCs) estrogen receptor 1(ESR1) thioredoxin 2(Trx2) mitochondrial membrane potential(MMP)
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Panax quinquefolius polysaccharides enhance the therapeutic efficacy of rare ginsenosides in mice infected with Listeria monocytogenes by inhibiting NF-κB and regulating macrophage polarization 认领 引用
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作者 Yi He Hao Lu +7 位作者 Tai-Feng Cao Hai-Zhen Liu Ruo-Yu Zhang Ning Tang Cheng-Cheng Han Jin-Jin Jing Wen-Jing Jia Peng Xue 《Traditional Medicine Research》 2026年第7期12-24,共13页
Background:This study aims to investigate the therapeutic potential of rare ginsenosides(HTS)derived from Panax quinquefolius stem-leaf saponins(AGS)on LM infected mice,and to explore its synergistic anti LM mechanism... Background:This study aims to investigate the therapeutic potential of rare ginsenosides(HTS)derived from Panax quinquefolius stem-leaf saponins(AGS)on LM infected mice,and to explore its synergistic anti LM mechanism with its Panax quinquefolius polysaccharides(AGP).The mechanism by which AGP enhances the efficacy of rare ginsenosides is also explored through macrophage polarization.Methods:HTS was separated from total ginseng saponins;AGP was characterized using UV-Vis,IR spectroscopy,and monosaccharide composition analysis.An in vivo mouse model of LM infection was established,with penicillin and negative control groups.Efficacy was assessed by survival rate,organ bacterial load,ALT levels,inflammatory cytokines,and histopathology.An in vitro model used LTA-induced RAW264.7 macrophages,with NF-κB,CD68,and CD163 mRNA levels detected via qRT-PCR and immunofluorescence.Results:High-dose HTS(20 mg/kg)alone resulted in only 16.7%survival and significant liver injury.In contrast,HTS(5 mg/kg)and AGP(5 mg/kg)co-administration significantly increased survival to 66.7%,reduced hepatic bacterial load and ALT,downregulated IFN-γand IL-1β,and alleviated liver pathology.In vitro,HTS+AGP reduced LTA-induced cytotoxicity,suppressed NF-κB activation,and decreased secretion of NO,TNF-α,and IL-6.It also reversed the LTA-induced M1 macrophage bias by downregulating CD68 and upregulating CD163,increasing the CD163+/CD68+ ratio.Conclusion:AGP can enhance the therapeutic effect of HTS on LM infection by alleviating excessive inflammatory response in infected mice,regulating macrophage polarization balance,and providing experimental basis and theoretical support for the development of new anti-resistant bacterial strategies based on natural active ingredients and the rational application of rare saponins. 展开更多
关键词 Listeria monocytogenes rare ginsenosides Panax quinquefolius polysaccharide macrophage polarization
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Structural,morphological,and antibacterial characterization of Eu3+doped Angelica sinensis polysaccharides 认领 引用
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作者 Jixia Hou Tengyu Zhang +2 位作者 Jieying Zhao Ruofei Feng Chunxia Tan 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2026年第2期131-143,共13页
In the present study,a luminescent hybrid material(ASP/Eu)was synthesized by incorporating Eu3+into Angelica sinensis polysaccharides.Comprehensive characterization was conducted to evaluate its thermal stability,aggr... In the present study,a luminescent hybrid material(ASP/Eu)was synthesized by incorporating Eu3+into Angelica sinensis polysaccharides.Comprehensive characterization was conducted to evaluate its thermal stability,aggregate morphology,conformational features,photophysical behavior,and antibacterial activity.Incorporation of Eu enhanced the thermal stability of the polysaccharide matrix while inducing conformational alterations.Congo Red assays indicated that ASP/Eu lacked a triple-helix architecture and instead assembled into more compact sugar-chain aggregates exhibiting fluorescence.Weak luminescence from the Eu-doped polysaccharide was detectable both in the solid state and in aqueous solution,an observation further corroborated by SEM and TEM analyses.The minimum inhibitory concentration(MIC)of ASP/Eu was 800μg/mL,reducing the survival rate of E.coli to 5.38%±0.53% and S.aureus to 4.92%±1.49%.These antibacterial assays demonstrated that Eu incorporation significantly improved the bioactivity of the hybrid.Collectively,these findings provided a valuable foundation for advancing the biological exploration and potential applications of ASP/Eu hybrids. 展开更多
关键词 Luminescent polysaccharide Morphology Structure Antibacterial activity
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Platycodon grandiflorus polysaccharides combined with hesperidin exerted the synergistic effect of relieving ulcerative colitis in mice by modulating PI3K/AKT and JAK2/STAT3 signaling pathways 认领 引用 被引量：3
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作者 Yang Liu Quanwei Sun +5 位作者 Xuefei Xu Mengmeng Li Wenheng Gao Yunlong Li Ye Yang Dengke Yin 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2025年第7期848-862,共15页
Ulcerative colitis(UC)is a chronic inflammatory disorder with a complex etiology,characterized by intestinal inflammation and barrier dysfunction.Platycodon grandiflorus polysaccharides(PGP),the primary component of P... Ulcerative colitis(UC)is a chronic inflammatory disorder with a complex etiology,characterized by intestinal inflammation and barrier dysfunction.Platycodon grandiflorus polysaccharides(PGP),the primary component of Platycodon grandiflorus,and hesperidin(Hesp),a prominent active component in Citrus aurantium L.(CAL),have both demonstrated anti-inflammatory properties.This study aims to elucidate the underlying mechanism of the synergistic effect of PGP combined with Hesp on UC,focusing on the coordinated interaction between the phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)and Janus kinase 2(JAK2)/signal transducer and activator of transcription 3(STAT3)signaling pathways.A mouse model of UC induced by dextran sulfate sodium(DSS)and a cell model using lipopolysaccharide(LPS)-induced RAW264.7/IEC6 cells were employed to investigate the in vitro and in vivo anti-inflammatory effects of PGP combined with Hesp on UC and its potential mechanism of action.The results indicated that compared to the effects of either drug alone,the combination of PGP and Hesp significantly modulated inflammatory factor levels,inhibited oxidative stress,regulated colonic mucosal immunity,suppressed apoptosis,and restored intestinal barrier function in vitro and in vivo.Further in vitro studies revealed that PGP significantly inhibited the PI3K/AKT signaling pathway,while Hesp significantly inhibited the JAK2/STAT3 signaling pathway.The use of inhibitors and activators targeting both pathways validated the synergistic effects of PGP combined with Hesp on the PI3K/AKT and JAK2/STAT3 signaling pathways.These findings suggest that PGP combined with Hesp exhibits a synergistic effect on DSS-induced colitis,potentially mediated through the phosphatase and tensin homolog(PTEN)/PI3K/AKT and interleukin-6(IL-6)/JAK2/STAT3 signaling pathways. 展开更多
关键词 Ulcerative colitis Platycodon grandiflorus polysaccharides Hesperidin Synergistic effects PI3K/AKT JAK2/STAT3
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Structure-function insights of natural Ganoderma polysaccharides:advances in biosynthesis and functional food applications 认领 引用 被引量：2
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作者 Zhou-Wei Wu Xue-Fang Zhao +5 位作者 Chen-Xi Quan Xiao-Cui Liu Xin-Yu Tao Yu-jie Li Xing-Rong Peng Ming-Hua Qiu 《Natural Products and Bioprospecting》 CSCD 2025年第2期143-175,共33页
Ganoderma polysaccharides(GPs),derived from various species of the Ganoderma genus,exhibit diverse bioactivities,including immune modulation,anti-tumor effects,and gut microbiota regulation.These properties position G... Ganoderma polysaccharides(GPs),derived from various species of the Ganoderma genus,exhibit diverse bioactivities,including immune modulation,anti-tumor effects,and gut microbiota regulation.These properties position GPs as dual-purpose agents for medicinal and functional food development.This review comprehensively explores the structural complexity of six key GPs and their specific mechanisms of action,such as TLR signaling in immune modulation,apoptosis pathways in anti-tumor activity,and their prebiotic effects on gut microbiota.Additionally,the structure-activity relationships(SARs)of GPs are highlighted to elucidate their biological efficacy.Advances in green extraction techniques,including ultrasonic-assisted and enzymatic methods,are discussed for their roles in enhancing yield and aligning with sustainable production principles.Furthermore,the review addresses biotechnological innovations in polysaccharide biosynthesis,improving production efficiency and making large-scale production feasible.These insights,combined with ongoing research into their bioactivity,provide a solid foundation for developing health-promoting functional food products that incorporate GPs.Furthermore,future research directions are suggested to optimize biosynthesis pathways and fully harness the health benefits of these polysaccharides. 展开更多
关键词 Ganoderma polysaccharides extraction techniques structural characteristics Bioactivity biosynthetic pathways Functional food applications
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Yeast cell wall polysaccharides accelerate yet in-feed antibiotic delays intestinal development and maturation via modulating gut microbiome in chickens 认领 引用 被引量：1
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作者 Fangshen Guo Jianing Qiao +6 位作者 Zeqiong Hu Jia Huang Ruichen Bi Waseem Abbas Wenrui Zhen Yuming Guo Zhong Wang 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2025年第3期1353-1367,共15页
Background It is important to promote intestinal development and maturation of chicks for feed digestion and utilization,intestinal health,and disease resistance.This study aimed to investigate the effects of dietary ... Background It is important to promote intestinal development and maturation of chicks for feed digestion and utilization,intestinal health,and disease resistance.This study aimed to investigate the effects of dietary yeast cell wall polysaccharides(YCWP)addition on intestinal development and maturation of chickens and its potential action mechanism.Methods 180 one-day-old male Arbor Acres broilers were randomly assigned to three groups containing control(basal diets without any antibiotics or anticoccidial drug),bacitracin methylene disalicylate(BMD)-treated group(50 mg/kg)and YCWP-supplemented group(100 mg/kg).Results Compared with control group,in-feed antibiotic BMD continuous administration significantly decreased crypt depth(d 21)and villus height(d 42)along with mucosal maltase activity(d 42)in the ileum(P<0.05).Also,BMD markedly downregulated gene expression levels ofβ-catenin,lysozyme,occludin and FABP-2(d 21)and innate immune related genes CD83 and MHC-I mRNA levels(d 42,P<0.05),and decreased goblet cell counts in the ileum of chickens(d 21 and d 42,P<0.05).While,TLR-2,TLR-6 and iNOS mRNA abundances were notably upregulated by BMD treatment(d 42,P<0.05).Nevertheless,dietary YCWP addition significantly increased the ratio of villus height to crypt depth(d 21),villus surface area(d 21 and d 42),ileal alkaline phosphatase and maltase activities as well as goblet cell(d 21 and d 42)and IgA-producing plasma cell numbers as compared to BMD treatment(d 21,P<0.05).YCWP addition also upregulated gene expression levels of Lgr5,Wnt/β-catenin signaling pathway related gene(Wnt3,β-catenin,d 21;β-catenin,d 42),intestinal cells proliferation marker Ki-67 and barrier function related genes(occludin,d 21 and d 42,P<0.05).Moreover,YCWP significantly increased antigen presenting cell marker related genes(MHC-II,d 21;CD83 and MHC-I,d 42),TLR-1,TLR-2 and TLR-6 mRNA levels(d 21,P<0.05).Cecal microbiome analysis showed that YCWP addition obviously improved cecal microbial composition,as indicated by increasing relative abundance of Fournierella,Psychrobacter and Ruminiclostridium on d 21,and Alistipes and Lactobacillus on d 42,which were positively related with gut development and maturation related indexes(P<0.05).Conclusion Collectively, YCWP promoted yet antibiotic BMD delayed intestinal morphological and immunologicaldevelopment linked with modulating gut microbiome in chickens. 展开更多
关键词 Antibiotic Broiler chickens Gut development Microflora Yeast cell wall polysaccharides
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Prospects of sea buckthorn(Hippophae rhamnoides L.)polysaccharides:preparation,structural characterization,and bioactivities diversity 认领 引用 被引量：1
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作者 Shuyuan Shi Ruiyun Wu +4 位作者 Zixin Han Yu Sun Pinglan Li Fazheng Ren Nan Shang 《Food Science and Human Wellness》 SCIE CAS CSCD 2025年第1期11-28,共18页
Sea buckthorn(Hippophae rhamnoides L.)is a natural homologous substance of medicine and food.Polysaccharide,as one of its primary active components,has very superior biological activity and can be used as a dietary su... Sea buckthorn(Hippophae rhamnoides L.)is a natural homologous substance of medicine and food.Polysaccharide,as one of its primary active components,has very superior biological activity and can be used as a dietary supplement for functional foods,with good commercial prospects.Although initial progress has been made in the study of sea buckthorn polysaccharides,related studies have been fragmented and lacked systematic and generalization.This manuscript presents a critical analysis and systematic summary of the extraction and purification methods,structural characterization and physicochemical properties,biological activity and potential mechanisms,and structure-activity relationships of sea buckthorn polysaccharides.Accumulating evidence has indicated that sea buckthorn polysaccharides,which were widely prepared by water extraction and column chromatography purifications,exhibited exhibit superior biological activities in vitro and in vivo,including antioxidant,immunomodulatory,anti-inflammatory,hepatorenal protective,antibacterial,antiviral,and prebiotic activities.After analysis,it was concluded that there is a correlation between the relevant activities of sea buckthorn polysaccharides and that the structure of sea buckthorn polysaccharides has a great influence on their biological activity.We reviewed the challenges and limitations of sea buckthorn polysaccharides,summarized the critical aspects,and provided suggestions for potential breakthroughs in the research and application of sea buckthorn polysaccharide. 展开更多
关键词 Sea buckthorn Polysaccharides Preparation Structural characterization Bioactivities
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Structural characterization of blueberry fruit polysaccharides and assessment of its hypolipidemic and immunological activity 认领 引用 被引量：1
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作者 Chuyan Wang Yuqi Qin +4 位作者 Xiaoao Cui Dongsheng Wang Yexian Hu Liuqing Yang Wei Lan 《Food Science and Human Wellness》 SCIE CAS CSCD 2025年第4期1360-1368,共9页
In this study,polysaccharides were extracted from blueberry fruit(BFP)and isolated to 3 components(BFP-1,BFP-2 and BFP-3).The molecular weight,monosaccharide composition,characteristic groups,microscopic morphology,an... In this study,polysaccharides were extracted from blueberry fruit(BFP)and isolated to 3 components(BFP-1,BFP-2 and BFP-3).The molecular weight,monosaccharide composition,characteristic groups,microscopic morphology,and triple helical conformation of the polysaccharides were characterized using high performance permeation chromatography,high performance liquid chromatography,gas chromatographymass spectrometry,Fourier transform infrared spectrometer,scanning electron microscope and Congo red staining.Moreover,the hypolipidemic and immunological activities of the polysaccharides were also assessed.Results showed that the molecular weights of polysaccharides BFP-1,BFP-2,and BFP-3 were 5.547×104,5.671×104,and 3.951×104Da,respectively,the main monosaccharides were glucose(Glc),galactose(Gal)and arabinose(Ara),but BFP-3 was mainly composed of galacturonic acid(Gal A),Glc,Gal,and Ara.The backbone of BFP-1 was→4)-Glcp-(1→,which branches to Ara and xylose(Xyl)residues,while the backbone of BFP-2 was→5)-Araf-(1→,which branches to Xyl,Glc,rhamnose(Rha)and Gal residues,in particularly,BFP-3 has a more complex branching with a→3,6)-Galp-(1→)backbone,the side chain is dominated by Araf-(1→).Blueberry polysaccharides are pyran-type polysaccharides withα-glycosidic bonds,and BFP-1 has a typical triple-helical structure.The activity assay revealed that the binding of BFP-3 to sodium glycylcholate hydrate and sodium taurocholate was 79.95%and 78.50%,respectively,indicating that it had better hypolipidemic activity than the others.Immunoactivity assay showed that BFP promoted NO secretion through activating the NF-κB signalling pathway in RAW264.7 cells,which played a role in enhancing the immune function of the organism.These findings may provide a reference for the development and application of blueberry polysaccharides in functional food and medicine. 展开更多
关键词 Blueberry fruit polysaccharides Structural characterization Hypolipidemic Immunological activity
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