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Achieving enhancing endosome escape of Tat47-57-derived stapled peptides through decafluorobiphenyl bridge 认领 引用
1
作者 Shu Li Yuanyuan Tang +4 位作者 Xiaojing Liu Shibo Song Baokang Zhu Min Chang Yali Peng 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第4期543-550,共8页
Cell-penetrating peptides(CPPs)hold great potential as a tool using non-invasive delivery of therapeutic or diagnostic molecules into mammalian cells,but their broad application has been limited by poor endosomal esca... Cell-penetrating peptides(CPPs)hold great potential as a tool using non-invasive delivery of therapeutic or diagnostic molecules into mammalian cells,but their broad application has been limited by poor endosomal escape.Thus,the rational design and selection of CPPs remains a challenge and calls for deeper mechanistic understandings.Here,we developed novel stapled cell-penetrating peptides based on the highly positively charged HIV Tat47-57 peptide using decafluorobiphenyl-cysteine SNAr chemistry which selectively disrupt endosomal membranes.A series of stapled peptides with a cross-linked structure were synthesized and investigated their cellular uptake,endosomal escape and intracellular delivery of cargoes.Among these peptides,analogues P3 and P6 demonstrated the highest cellular uptake and endosomal escape activities with efficiencies 3.5-9-fold higher than that of Tat47-57.Notably,the results demonstrated that the decafluorobiphenyl bridge of stapled peptides exhibited significant ability for cellular uptake and endosomal escape.Moreover,we found that fluorine atoms of decafluorobiphenyl bridge played a key role for disrupting endosomal membranes.Finally,the utility of this strategy has been demonstrated by the intracellular delivery of biomacromolecules(avidin and negatively charged phosphopeptides).Together,these results suggest that the decafluorobiphenyl-cysteine SNAr chemistry may be an efficient strategy for the development of novel stapled CPPs. 展开更多
关键词 Cell-penetrating peptides Endosomal escape Decafluorobiphenyl bridge Stapled peptides Intracellular delivery
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Bioengineered α-Hairpin peptide TKH with GKG linker:a LLPS-mediated biomimetic mineralization system for intrafibrillar remineralization and deep dentin tubule occlusion 认领 引用
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作者 Yeling Ou Jing Wang +6 位作者 Luoyao Wang Haisheng Wang Fengfan He Longjiang Ding Yanping Zhou Sili Han Linglin Zhang 《International Journal of Oral Science》 SCIE CAS CSCD 2026年第3期474-487,共14页
Dentin hypersensitivity(DH)originates from collagen exposure and dentinal tubules(DTs)patency caused by mechanical abrasion or demineralization.For an effective long-term therapeutic desensitizing agent,the ability to... Dentin hypersensitivity(DH)originates from collagen exposure and dentinal tubules(DTs)patency caused by mechanical abrasion or demineralization.For an effective long-term therapeutic desensitizing agent,the ability to achieve deep tubular occlusion,stable remineralization,and satisfactory biocompatibility simultaneously is essential.In this study,we designed a novel α-hairpin peptide,TKH,engineered by incorporating a flexible GKG linker into an α-helical template,and provide an analysis of its liquid-liquid phase separation(LLPS)and self-assembly properties.TKH effectively stabilized amorphous calcium phosphate and facilitated intrafibrillar mineralization within collagen fibrils.In vitro and in vivo remineralization studies combined with molecular dynamics(MD)simulations demonstrated that TKH promoted the peptide self-assembly through LLPS,hydroxyapatite(HA)adsorption,and amorphous calcium phosphate(ACP)stabilization,ultimately achieving intrafibrillar and extrafibrillar mineralization to seal DTs,alongside excellent biosafety.These findings highlight the potential of TKH as a promising peptide-based biomaterial for dentin remineralization and the treatment of dentin hypersensitivity. 展开更多
关键词 TKH incorporating flexible gkg linker dentin hypersensitivity dh originates dentinal tubules dts patency desensitizing agentthe bioengineered peptides deep tubular occlusionstable hairpin peptide
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A bibliometric visualization analysis of walnut protein peptide applications:Hotspot evolution and future trends 认领 引用
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作者 Jinxia Gao Xuyan Dong +6 位作者 Jiawen Yan Chao Gao Shengxiang Gong Jiqu Xu Yan Zhang Junxia Xiao Liang Liu 《Oil Crop Science》 CAS CSCD 2026年第2期129-137,共9页
This study maps the knowledge structure of walnut protein peptide research(2012-2025)through a bibliometric analysis of 229 publications retrieved from the Web of Science Core Collection,using tools such as Bibliometr... This study maps the knowledge structure of walnut protein peptide research(2012-2025)through a bibliometric analysis of 229 publications retrieved from the Web of Science Core Collection,using tools such as Bibliometrix,VOSviewer,and CiteSpace.The results show that there is a clear publication output increase trend.China is the major contributor,South China University of Technology ranks as the top research institution,Journal of Agricultural and Food Chemistry is the core journal,and Min WH and Wang SG are the most cited authors.Furthermore,based on the most cited articles,the study finds research hotspots in the extraction of antioxidant and neuroprotective peptides,bioavailability and absorption mechanisms,and structure-activity relationships,which can be used to promote the research of walnut protein peptide and the development of walnut meal industry. 展开更多
关键词 Walnut-derived peptides Bibliometric analysis Visualization Bioactive peptides
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Study on antioxidant synergistic anti-inflammatory peptide from giant salamander(Andrias davidianus):functional mechanism and delivery by nano-starch 认领 引用
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作者 Junqi Zhan Qiaobo Zhang +5 位作者 Siyan Mei Junxin Wu Yanwei Yuan Gaoshang Li Jingjing Fu Yuewen Chen 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第7期3237-3244,共8页
In this study,we explored the anti-inflammatory and antioxidant characteristics of the giant salamander peptide P3.We found that P3 enhances the resistance of RAW264.7 cells to lipopolysaccharide by modulating the mit... In this study,we explored the anti-inflammatory and antioxidant characteristics of the giant salamander peptide P3.We found that P3 enhances the resistance of RAW264.7 cells to lipopolysaccharide by modulating the mitogen-activated protein kinaseuclear factor kappa-light-chain-enhancer of activated B cells(MAPK/NF-κB)signaling pathway.Specifically,P3 boosted the activation of MAPK,interleukin-6,and tumor necrosis factor alpha,while decreasing levels of inflammatory factors like interleukin-1βand nitric oxide.Given its potent antioxidant properties,we further examined impact of P3 in the Keap1-ARE-Nrf2 signaling pathway and its products.P3 increased the levels of antioxidant enzymes such as glutathione peroxidase and superoxide dismutase,while reducing the concentrations of oxidation products like malondialdehyde and catalase.During in vitro digestion,the functional efficacy of P3 diminished.However,when combined with nano-starch(NS),NS-P3 demonstrated preserved functionality.Our findings indicate that P3 not only exhibits anti-inflammatory effects but also mitigates chronic oxidative stress damage.NS-P3 effectively safeguards the antioxidant capabilities of P3 during simulated digestion. 展开更多
关键词 Antioxidant peptides Anti-infl ammatory peptides Nano-starch In vitro digestion
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A clinically guided photocurable hydrogel platform for antimicrobial peptide substitution in personalized wound infection therapy 认领 引用
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作者 Xiaolong Lin Tao Fu +3 位作者 Yuqing Lei Jiajia Xu Haihua Zhu Fudong Zhu 《Bio-Design and Manufacturing》 SCIE EI CAS CSCD 2026年第3期539-562,I0010,I0011,共24页
The healing of infected skin wounds remains a major clinical challenge due to persistent bacterial contamination and prolonged inflammation.In this study,we report the development of a multifunctional,light-curable so... The healing of infected skin wounds remains a major clinical challenge due to persistent bacterial contamination and prolonged inflammation.In this study,we report the development of a multifunctional,light-curable sodium alginate-based hydrogel by grafting antimicrobial peptides(AMPs)onto oxidized sodium alginate(OSA)via Schiff base reactions and incorporating silver nanoparticles(AgNPs).The dual-network hydrogel,formed by blending AMP@OSA with methacrylated alginate(AlgMA)and subsequent ultraviolet(UV)curing,exhibited a pH-responsive release behavior targeting the acidic microenvironment of infected wounds.In vitro studies demonstrated strong antibacterial activity against Staphylococcus aureus and Escherichia coli,significant inhibition of biofilm formation,and excellent biocompatibility,evidenced by minimal cytotoxicity and hemolysis.Treatment of a rat dorsal full-thickness infected wound model with the AMP-AgNPs@OSA hydrogel markedly accelerated wound closure,enhanced re-epithelialization,and promoted collagen deposition.Mechanistically,the hydrogel modulated the immune microenvironment by inducing macrophage polarization toward the anti-inflammatory M2 phenotype,thereby mitigating inflammatory responses and supporting tissue regeneration.These findings establish AMP-AgNPs@OSA hydrogel as a multifunctional dressing capable of simultaneously controlling infection and promoting wound repair,with strong potential for advanced clinical use in the management of infected skin defects.Moreover,the antimicrobial peptide component can be flexibly replaced with clinically appropriate antibiotics based on antimicrobial susceptibility testing,allowing personalized infection control and expanding the hydrogel’s translational relevance across diverse pathogens. 展开更多
关键词 Antimicrobial peptide Hydrogel Wound healing Anti-inflammatory
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Identification of broad-spectrum B-cell and T-cell epitopes of H9 subtype avian influenza virus HA protein using polypeptide scanning 认领 引用
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作者 Keji Quan Nan Zhang +10 位作者 Mengqi Lin Yuan Liu Yue Li Qun Hu Maoshun Nie Tao Qin Jingzhi Li Hongwei Ma Sujuan Chen Daxin Peng Xiufan Liu 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2026年第4期1636-1646,共11页
The H9N2 subtype avian influenza virus(AIV)hemagglutinin(HA)protein is a major immunogen in which HA1 is a genetic variant and HA2 is relatively conserved.Identifying broad-spectrum antigen epitopes targeting HA1 is c... The H9N2 subtype avian influenza virus(AIV)hemagglutinin(HA)protein is a major immunogen in which HA1 is a genetic variant and HA2 is relatively conserved.Identifying broad-spectrum antigen epitopes targeting HA1 is crucial for vaccine design and detection.Based on the phylogenetic and serological analyses,we identified 2 antigenic groups and 3 representative viruses:A/chicken/Jiangsu/JY040218C/2019,A/pigeon/Jiangsu/JY020616/2019,and A/chicken/Jiangsu/WX090312/2018.An overlapping peptide library was synthesized using HA1 amino acid sequences of the viruses as templates.Through peptide scanning of the sera against different strains of H9N2 subtype AIV,we identified peptides from 4 regions(H9-2/3,H9-20/21,H9-26,and H9-29/30/31)that demonstrated broad-spectrum reactivity.Immunological assay results demonstrated that H9-21(219RIFKPLIGPRPLVNGLMGRI239),H9-26(269SGESHGRILKTDLKMGSCTV289),and H9-30(309YAFGNCPKYI GVKSLKLAVG329)effectively induced antibody generation and conferred partial protective efficacy against the parent virus JY040218C.The results of lymphocyte proliferation and ELISpot assays indicated that peptides H9-15(159MRWLTQKNNAYPTQDAQYTN179),H9-22(229PLVNGLMGRINYYWSVLKP G249),and H9-23(239NYYWSVLKPGQTLRIKSDGN259)could effectively stimulate the expression of interferon-gamma in peripheral blood lymphocytes of chickens immunized against different strains of H9N2 AIV.Collectively,5 novel cell epitopes H9-15,H9-22,H9-23,H9-26,and H9-30,including the best B cell epitope H9-26 and the best T cells epitope H9-22,were identified that could be targeted for vaccine design or detection approaches against H9N2 AIVs. 展开更多
关键词 H9N2 subtype avian influenza virus HA protein epitope microarray peptide
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Synergistic potential of peptide-lanthanide architectures for biomedical applications 认领 引用
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作者 Jean Claude Munyemana Xiuxia Sun +1 位作者 Eskandar Qaed Jianxi Xiao 《Journal of Rare Earths》 SCIE EI CAS CSCD 2026年第7期1969-1993,I0001,共25页
Peptide-conjugated lanthanide-based materials are emerging as highly promising platforms in molecular biosensing and bioimaging,offering new opportunities for advancing diagnostic technologies in biomedical applicatio... Peptide-conjugated lanthanide-based materials are emerging as highly promising platforms in molecular biosensing and bioimaging,offering new opportunities for advancing diagnostic technologies in biomedical applications.The unique photophysical(e.g.,sharp emission bands,long luminescence lifetimes)and magnetic(e.g.,paramagnetism,high relaxivity)properties of lanthanide ions and nanomaterials,when combined with the molecular specificity and biocompatibility of peptides,create a synergistic system that significantly enhances detection sensitivity and imaging resolution.Peptides,owing to their structural diversity and the chemical functionalities of their amino acid residues,can be designed to exhibit high selectivity toward specific molecular targets.Their inherent modularity and ease of chemical modification make them ideal ligands for co njugation with lanthanides,facilitating the fabrication of highly tunable diagnostic probes.This synergy enables precise molecular recognition,selective targeting,and efficient signal transduction in both biosensing platforms and imaging modalities such as fluorescence,magnetic resonance imaging(MRI),and computed tomography(CT).This review provides an informative and comprehensive overview of recent advances in peptide-lanthanide hybrid systems,covering their design strategies,synthesis approaches,functionalization techniques,and biomedical applications.We examine their applicability across diverse platforms,including biosensing technologies,advanced imaging modalities,targeted drug delivery systems,and tissue scaffolding.Key developments in these areas are highlighted to emphasize their emerging significance in bio medical applications.Furthermo re,we critically assess the curre nt challenges and knowledge gaps in the field,proposing future directions for research at the intersection of bioorganic chemistry,materials science,and molecular diagnostics.By illuminating the synergistic interactions between peptides and lanthanide-based materials,this work underscores their transformative potential in next-generation biosensing and bioimaging applications. 展开更多
关键词 Lanthanide Peptide Biomedical applications Bioimaging Biosensing Rare earths
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Immunoregulatory peptides from Ganoderma sinense:characterization,isolation,molecular docking and molecular mechanism 认领 引用
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作者 Qian Yang Nanwen Zhang +6 位作者 Huihong Zhang Xiaolin Huang Xixi Cai Ying Wu Jie Zhou Xiaole Chen Shaoyun Wang 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第3期1384-1398,共15页
Ganoderma sinense is a traditional and protein-rich edible fungus with outstanding immunoregulatory activity.However,the mechanism through which G.sinense protein hydrolysates and peptides exert their immunomodulatory... Ganoderma sinense is a traditional and protein-rich edible fungus with outstanding immunoregulatory activity.However,the mechanism through which G.sinense protein hydrolysates and peptides exert their immunomodulatory effects is unclear.The objective of this study was to prepare and isolate immunologically active peptides from G.sinense protein hydrolysates(GSP) and to investigate their impact on the activation of macrophages.G.sinense peptides with low molecular weights(< 1 kDa,87.76%) markedly promoted RAW264.7 cell proliferation;increased their phagocytic capacity,nitric oxide(NO),tumor necrosis factor-α(TNF-α),interleukin-10(IL-10),and IL-6 secretion and reactive oxygen species(ROS) production;and upregulated Tlr2 mRNA expression.In addition,GSP promoted nuclear factor kappa-B(NF-κB) activation and translocation through the upregulation of p65 and p-p65 protein expression.Virtual molecular screening technology revealed that compared with other peptides,the SFAGNIPVNR,YGDAFIR and TVSYLPAPQR peptides derived from GSP showed stronger binding affinities.Interaction site map analysis indicated that the SFAGNIPVNR and YGDAFIR peptides formed stable hydrogen bonds with toll-like receptor 2(TLR2).Together,these results suggested that G.sinense peptides can serve as important ingredients in nutraceuticals or functional foods. 展开更多
关键词 Immunoregulatory peptide Ganoderma sinense Nuclear factor kappa-B Toll-like receptor 2
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Internalization and transport mechanisms of the walnut-derived peptide in bEnd.3 cells 认领 引用
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作者 Qiao Dang Peng Wang +4 位作者 Zehui Li Chunlei Liu Fanrui Zhao Xingquan Liu Weihong Min 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第2期750-762,共13页
The blood-brain barrier(BBB)is a major challenge in drug delivery for the treatment of central nervous system diseases.Walnut derived peptide TWLPLPR(TW-7)has been proved to promote neuronal mitochondrial autophagy an... The blood-brain barrier(BBB)is a major challenge in drug delivery for the treatment of central nervous system diseases.Walnut derived peptide TWLPLPR(TW-7)has been proved to promote neuronal mitochondrial autophagy and enhance hippocampal neuronal synaptic plasticity,thereby improving learning and memory abilities in mice.We investigated the internalization mechanism and intracellular transport pathway for the walnut-derived peptide,TW-7,using b End.3 cells in an in vitro BBB model system.TW-7 was taken up by the b End.3 cells in a concentration-,temperature-,and energy-dependent manner;this involved increases in caveolin-1 and caveolin-2 protein expression and phosphorylation and inhibition of P-glycoprotein-mediated efflux.Subcellular localization of TW-7 in b End.3 cells was observed,indicating that the plasma membrane,endoplasmic reticulum,Golgi apparatus,lysosomes,and mitochondria participated in intracellular trafficking and that the peptide escaped from lysosomes over time.Caveolae may be critical for TW-7 uptake by brain microvascular endothelial cells,assisting TW-7 to cross the BBB.The results of this study provide a theoretical basis for the mechanism of active peptide penetrating the BBB,and provide a reference for developing neuroprotective active peptide products. 展开更多
关键词 Walnut-derived peptides Endothelial cells Blood-brain barrier Caveolin Transport mechanism
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Transition metal-catalyzed C-H activation/annulation for the construction of unnatural amino acids and peptides 认领 引用
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作者 Xiao Tang Erik V.Van der Eycken Liangliang Song 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第2期191-205,共15页
Peptides play important roles in chemistry,medicinal chemistry and life science,due to their high efficiency and specificity,unusual biological and therapeutic properties.As naturally occurring peptides often face wit... Peptides play important roles in chemistry,medicinal chemistry and life science,due to their high efficiency and specificity,unusual biological and therapeutic properties.As naturally occurring peptides often face with their intrinsic limitations including metabolic instability and low membrane permeability,the strategies for synthesizing unnatural amino acids and peptides are explored.Among the methods for modifying amino acids and peptides,chemo-and site-selective approaches are preferred because of the ability to fine-tuning structural features.Recently,transition metal-catalyzed C–H activation has been employed for the functionalization of amino acids and peptides.Through domino C–H activation/annulation,a series of structurally complex and diverse amino acids and peptides is constructed.This review highlights recent advances in the synthesis of unnatural amino acids and peptides via transition metal-catalyzed C–H activation/annulation. 展开更多
关键词 Amino acid Peptide Transition metal C-H activation Annulation
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Investigating the interactive adhesion ability between Limosilactobacillus reuteri DSM17938 and HT-29 cells regulated by soybean proteins and soybean peptides 认领 引用
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作者 Yinxiao Zhang Chi Zhang +3 位作者 Jingyi Wang He Li Xinqi Liu Xianyong Liu 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第5期2198-2206,共9页
In this study,digested soybean protein(dspr)and peptides(dspe)were found to have different effects on the adhesion ability of Limosilactobacillus reuteri DSM17938 and HT-29 cells.Results found that dspr and dspe could... In this study,digested soybean protein(dspr)and peptides(dspe)were found to have different effects on the adhesion ability of Limosilactobacillus reuteri DSM17938 and HT-29 cells.Results found that dspr and dspe could increase L.reuteri adhesion ability by affecting their auto-aggregation and hydrophobicity during their stationary phase.The moonlighting protein may play a dominant role affected by dspe in the adhesion process of L.reuteri from stationary phase.Moreover,dspr and dspe also enhanced the adhesion ability of HT-29cells to L.reuteri DSM17938,and they might play different role at different stages of adhesion.dspr mainly promoted the expression of adhesion-related genes before L.reuteri adhesion.dspe increased them after the adhesion of L.reuteri from log phase and dspr mainly enhanced their expression after stationary phase L.reuteri adhesion.Soybean protein and peptides may therefore be considered as a potential effective modulator of L.reuteri adhesion to intestinal tract. 展开更多
关键词 Soybean protein Soybean peptides Limosilactobacillus reuteri DSM17938 Adhesion Surface protein
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Why Static SAR Fails for Antimicrobial Peptides From an Ensemble and Free-Energy Landscape Perspective? 认领 引用
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作者 Cesar Augusto Roque-Borda Anamika Sharma +2 位作者 Fernando Rogério Pavan Beatriz G.de la Torre Fernando Albericio 《Aggregate》 EI CAS CSCD 2026年第4期65-74,共10页
Classical structure–activity relationships(SAR)have limited predictive power for antimicrobial peptides(AMPs)because they assume fixed structures,single mechanisms,and independent physicochemical descriptors.In pract... Classical structure–activity relationships(SAR)have limited predictive power for antimicrobial peptides(AMPs)because they assume fixed structures,single mechanisms,and independent physicochemical descriptors.In practice,AMP activity arises from dynamic,multistate ensembles that reorganize with environment,concentration,and membrane context.Here,we propose that the AMP function is best described using an ensemble-based chemical framework grounded in free-energy landscapes and interfacial thermodynamics.Peptide sequences encode distributions of chemically accessible states rather than unique bioactive conformations,while environmental variables selectively redistribute these populations across interfacial,inserted,and oligomeric regimes.Biological outcomes such as membrane disruption,intracellular access,and selectivity emerge as conditional consequences of state population shifts rather than intrinsic sequence-encoded mechanisms.This perspective provides a chemically grounded alternative to static SAR and suggests that effective AMP design should focus on controlling ensemble redistribution under realistic interfacial environments. 展开更多
关键词 antimicrobial peptides ensemble behavior free-energy landscapes interfacial thermodynamics structure–activity relationships
Advances in cell-penetrating peptides for cytoplasmic delivery of fluorescent probes 认领 引用
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作者 Simei Zhong Peng Xu +3 位作者 Yunfei Wei Xinxin Duan Shanshan Zhao Yu-Hui Zhang 《Journal of Innovative Optical Health Sciences》 SCIE EI CSCD 2026年第1期1-29,共29页
Fluorescent probes,with their superior optical properties and labeling versatility,have greatly advanced the visualization of intracellular molecules and subcellular structures.However,poor cytoplasmic delivery,caused... Fluorescent probes,with their superior optical properties and labeling versatility,have greatly advanced the visualization of intracellular molecules and subcellular structures.However,poor cytoplasmic delivery,caused by charge,size,or targeting groups,limits the effective use of many fluorescent probes in live cells.Recently,cell-penetrating peptides(CPPs)have emerged as efficient carriers,offering great potential for the cytoplasmic delivery of fluorescent probes in live cells.This review provides a comprehensive overview of CPPs as vehicles for probe delivery,outlining advances in their development,conjugation chemistries,and intracellular delivery mechanisms.Recent applications in live-cell imaging are highlighted and organized according to major CPP modification strategies,including sequence engineering,cyclization,hybrid design and enhancement by chemical reagents.Finally,the challenges that remain and the future outlook of this rapidly evolvingfield are discussed. 展开更多
关键词 Fluorescent probes cell-penetrating peptides live-cell cytoplasmic delivery
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Naturally derived oncolytic peptides:from discovery to clinical translation 认领 引用
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作者 Jiyuan Zhang Yi Chen +6 位作者 Shengxin Lu Xiaokun Zhang Guanrunze Yang Zhidan Zhang Ye Wu Xuemei Zhang Weidong Zhang 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2026年第6期696-709,共14页
Oncolytic peptides have emerged as a distinct class of antitumor agents with the potential to overcome therapeutic resistance and enhance anticancer immunity.Most oncolytic peptides are naturally derived or structural... Oncolytic peptides have emerged as a distinct class of antitumor agents with the potential to overcome therapeutic resistance and enhance anticancer immunity.Most oncolytic peptides are naturally derived or structurally inspired by natural peptides,and typically display cationic and amphipathic features.Mechanistically,these physicochemical properties enable preferential binding to the negatively charged membranes of cancer cells and subsequent membrane disruption.Beyond direct membrane lysis,many naturally derived oncolytic peptides(NDOPs)perturb intracellular organelle membranes,trigger immunogenic cell death,and modulate immune cells and immune checkpoints,thereby amplifying the cancer-immunity cycle.Through these multifaceted mechanisms,NDOPs show a low tendency to induce drug resistance and can enhance response rates when combined with conventional therapies.Notably,four NDOP-based agents have advanced into clinical trials,underscoring their translational promise.In this review,we summarize the sources,structural features,and mechanisms of NDOPs,highlight innovative therapeutic applications and rational combination strategies,and further discuss the current clinical progress.We also outline key challenges and future directions for the development of NDOPs as next-generation anticancer therapeutics. 展开更多
关键词 Naturally derived oncolytic peptides Sources and structures Pharmacological mechanisms Combination therapy Clinical progress
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Marine-derived products as pharmaceutical treasure troves:a focus on recent research techniques and potential bioactive activities of marine peptides 认领 引用
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作者 Xiangyu Cheng Ziqi Tang +5 位作者 Zhongqi Li Shuaijie Hu Kehan Qin Yindi Zhao Baoming Hao Qinghua Hu 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2026年第5期543-558,共16页
With the intensified exploration of marine resources,marine bioactive peptides have become one of the research focuses in biomedicine,food science,and materials science because of their structural diversity,unique bio... With the intensified exploration of marine resources,marine bioactive peptides have become one of the research focuses in biomedicine,food science,and materials science because of their structural diversity,unique biological activities,and broad application potential.At present,the extraction of marine peptides has expanded beyond conventional chemical extraction and enzymatic hydrolysis,with microbial fermentation and gastrointestinal simulation technologies further broadening peptide diversity.In addition,the integration of multiple chromatographic techniques with advanced detectors has significantly improved the efficiency of marine peptide identification.Owing to their diverse biological activities,including immunoregulatory,antioxidant,antibacterial,antitumor,hypotensive,and hypoglycemic effects,marine peptides not only enrich the pool of candidates for marine drug development but also provide new perspectives for addressing numerous health challenges.Importantly,substantial progress has been made in the screening,identification,and mechanistic elucidation of marine bioactive peptides,driven by advances in high-throughput technologies and the bioinformatics.However,marine peptide research still faces several challenges,including complex sourcing,difficulties in large-scale acquisition,and insufficient exploration of biological activities.Therefore,this article concisely reviews recent progress in the extraction,purification,and identification of marine bioactive peptides,summarizes current research on their biological activities,and highlights the application of bioinformatics in marine peptide studies. 展开更多
关键词 Marine peptides Extraction technology Separation and purification Biological activities Bioinformatics
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Comparative analysis of Andrias davidianus bone-derived peptides from distinct habitats and their antihyperuricemic activity 认领 引用
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作者 Wei Li Hongliang Chen +2 位作者 Haihong Chen Bing Xu Xinhui Xing 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第5期2067-2083,共17页
Andrias davidianus bone peptides(ADBP),known for their potent xanthine oxidase(XOD)inhibitory activity,show promise as adjunctive agents for the treatment of hyperuricemia(HUA).However,their quality control and antihy... Andrias davidianus bone peptides(ADBP),known for their potent xanthine oxidase(XOD)inhibitory activity,show promise as adjunctive agents for the treatment of hyperuricemia(HUA).However,their quality control and antihyperuricemic efficacy across different farming regions have not been thoroughly investigated.This study undertook a comparative analysis of ADBP from nine representative farming locations,developed a high-performance liquid chromatography(HPLC)fingerprint,and evaluated the antihyperuricemic activity of the most promising sample both in vitro and in vivo.The nine ADBP samples predominantly consisted of low-molecular-weight peptides with high protein content.However,their mineral and amino acid profiles exhibited significant variability,which served as key distinguishing markers.A reliable HPLC fingerprint was established to characterize ADBP from the different farming regions.Based on compositional analysis and XOD inhibitory activity,the ADBP obtained from the Hunan Zhangjiajie(HNZJJ)region was selected for further investigation.In vitro experiments utilizing an optimized adenosine-induced HUA model in LO2 cells confirmed the uric acid-lowering effect of the selected ADBP.In vivo experiments using a mouse model demonstrated that ADBP significantly suppressed hepatic uric acid synthesis by inhibiting adenylate deaminase(ADA),XOD activity,and reducing serum uric acid levels.Additionally,ADBP alleviated HUAinduced liver damage by enhancing hepatic antioxidant defenses.Metabolomic analysis revealed that ADBPinduced alterations in liver metabolites may contribute to the alleviation of HUA.These metabolites were notably enriched in pathways related to linoleic acid metabolism,arginine and proline metabolism,caffeine metabolism,cysteine and methionine metabolism,and purine metabolism.These findings underscore the potential of ADBP as a functional ingredient for food and biomedical applications aimed at the prevention and adjunctive treatment of HUA. 展开更多
关键词 Andrias davidianus bone Peptides Composition analysis High performance liquid chromatography fingerprint Antihyperuricemic activity
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Peptides derived from exocrine secretions of venomous animals used as traditional Chinese“worm”medicines 认领 引用
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作者 Shian Lai Jinwei Chai +2 位作者 Yongtao Luo Lei Luo Xueqing Xu 《Zoological Research》 SCIE CSCD 2026年第1期233-249,共17页
The term“worm medicines”(Chong Yao)in Traditional Chinese Medicine encompasses a diverse category of small animal-derived therapeutics,including arthropods,amphibians,and reptiles,rather than strictly vermiform orga... The term“worm medicines”(Chong Yao)in Traditional Chinese Medicine encompasses a diverse category of small animal-derived therapeutics,including arthropods,amphibians,and reptiles,rather than strictly vermiform organisms.Many of these animals,such as scorpions,centipedes,toads,and horseflies,are toxic,and have been employed in clinical practice for centuries,despite limited understanding of their active compounds and underlying modes of action.Among the bioactive constituents extracted from these taxa,peptides represent a particularly promising class,with over 2000 identified to date.These peptides are primarily secreted from specialized exocrine glands,including venom,salivary,and cutaneous glands,and are characterized by high structural diversity and target specificity.Their potent modulatory effects on the nervous,cardiovascular,and immune systems make them excellent candidates for drug discovery and development.This review examines peptide-based compounds derived from the exocrine secretions of venomous and poisonous taxa historically employed in traditional Chinese“worm”medicines.Emphasis is placed on their biological origins,structural features,and pharmacological activities,highlighting their significant potential as a rich and largely untapped resource for modern therapeutic discovery. 展开更多
关键词 Poisonous worms Pharmacological constituents Mechanisms Traditional Chinese"worm"medicines Peptides Physiological elements Drug discovery
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Autocrine Motility Factor-Derived Tetradecapeptides as Dual-Action Chemosensitizers:Bridging Cell Competition Mechanisms with Clinical MDR Reversal in Hematological Malignancies 认领 引用
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作者 Changyul Kim Yu Ju Jung +3 位作者 Da Hee Son Na Young Kim Se Gie Kim Hee Sung Park 《Oncology Research》 SCIE 2026年第7期416-433,共18页
Backgrounds:Autocrine motility factor(AMF)represents a paradoxical protein with dual roles in cancer progression and therapy.This study investigated AMF-derived tetradecapeptides as novel chemosensitizing agents to ov... Backgrounds:Autocrine motility factor(AMF)represents a paradoxical protein with dual roles in cancer progression and therapy.This study investigated AMF-derived tetradecapeptides as novel chemosensitizing agents to overcome multidrug resistance(MDR)in hematological malignancies(HMs).Methods:Seven AMF variants were screened for anticancer activity across 14 human cancer cell lines using MTT and Cell Counting Kit-8(CCK-8)assays.Four tetradecapeptides(AMF-derived peptides AAP,HGP,HTP,and SKP)corresponding to the AMF206-219 region were designed and evaluated in three HM cell lines(HL-60,CCRF-CEM,IM-9)for growth inhibition,cellular internalization,reactive oxygen species(ROS)production,mitochondrial membrane potential,and gene/protein expression.Synergism with doxorubicin(DOX)and other chemotherapeutic agents was quantified by combination index(CI)analysis using the Chou-Talalay method and spheroid culture assays.Results:AMF variants demonstrated broad-spectrum anticancer activity,with HL-60 acute promyelocytic leukemia cells showing exceptional sensitivity.AMF variants functioned as cell competition-mediated killing signals,converting cancer cells into metabolically compromised“loser”cells through glucose metabolism disruption and oxidative stress induction.Among the four tetradecapeptides,AAP exhibited the most consistent growth inhibition across HM cell lines(HL-60,CCRF-CEM,IM-9)while maintaining gp78/AMFR-mediated cellular internalization.AAP treatment induced dose-dependent ROS production,mitochondrial membrane potential alterations,and p53 upregulation,though glucose-6-phosphate dehydrogenase(G6PD)suppression showed cell-type specificity.Remarkably,AAP demonstrated potent synergistic effects with DOX,reducing IC50 values by 28–53%across tested HM cells through multiple complementary mechanisms:enhanced intracellular DOX retention,elevated oxidative stress,and downregulation of multidrug resistance protein 1(MDR1;P-glycoprotein)and multidrug resistance-associated protein 1(MRP1)in specific cell types.AAP similarly synergized with daunorubicin but not with etoposide or cytarabine,suggesting selectivity for ROS-inducing anthracyclines.Conclusions:These findings establish AMF-derived peptides as promising human-origin chemosensitizers capable of overcoming multidrug resistance in HMs through multi-targeted mechanisms.The ability to reduce anthracycline dosing while maintaining efficacy offers potential for minimizing cardiotoxicity and other dose-limiting adverse effects,warranting further preclinical development toward clinical translation. 展开更多
关键词 Autocrine motility factor peptide drug retention hematological malignancy multidrug resistance protein 1(MDR1) multidrug resistance-associated protein 1(MRP1)
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Targeting gangliosides to treat Alzheimer’s and Parkinson’s diseases:A disruptive approach with the first-in-class peptide AmyP53 认领 引用
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作者 Jacques Fantini Nouara Yahi 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第6期2339-2340,共2页
Neurodegenerative diseases are a growing burden on healthcare systems.Patients with Alzheimer’s or Parkinson’s diseases(AD or PD)are desperately waiting for innovative solutions that are slow to come,despite several... Neurodegenerative diseases are a growing burden on healthcare systems.Patients with Alzheimer’s or Parkinson’s diseases(AD or PD)are desperately waiting for innovative solutions that are slow to come,despite several decades of research worldwide.In 2021 and again in 2023,two monoclonal antibodies,aducanumab and lecanemab,have been approved by the U.S.Food and Drug Administration,and a third,donanemab,is currently under review.However,these treatments have very limited efficacy on cognitive functions and are accompanied by major side effects:amyloid-related imaging abnormalities,microhemorrhages,and accelerated brain volume loss(Høilund-Carlsen et al.,2024). 展开更多
关键词 neurodegenerative diseases cognitive functions Alzheimers monoclonal antibodiesaducanumab peptide Parkinsons diseases gangliosides
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Emerging trends in permeation-enhancing technologies for oral peptide delivery 认领 引用 被引量：1
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作者 Juan Tao Jinlong Yang +3 位作者 Mengyu Zhao Quangang Zhu Zhongjian Chen Jianping Qi 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第3期218-229,共12页
Peptides are increasingly favored as therapeutic agents due to their high efficacy,selectivity,and minimal side effects.However,they often face challenges related to poor stability and limited permeability through the... Peptides are increasingly favored as therapeutic agents due to their high efficacy,selectivity,and minimal side effects.However,they often face challenges related to poor stability and limited permeability through the gastrointestinal tract(GIT)and epithelia,necessitating parenteral administration.Despite this,there is a considerable demand for oral administration in clinical practice.To address the urgent clinical need for oral delivery,researchers have developed various technologies to surmount these challenges,including device-related systems,permeation enhancers(PEs),nanocarrier-based systems,and more.This review systematically explores the physiological barriers impacting peptide permeability and discusses the permeation-enhancing technologies designed to overcome them.It also reviews the oral peptide delivery systems currently available or under clinical investigation,offering insights into future developments in this field. 展开更多
关键词 Oral peptides Permeation-enhancing technologies Targeted delivery Physiological barriers Nanocarriers
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