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Phellodendron amurense Rupr.Polysaccharides protects against diabetic nephropathy via alteration of PI3K/GSK-3β/Nrf2/TGF-β/Smad signaling pathway and gut microbiota 认领 引用 被引量：1
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作者 Mei Mei Huawei Sun +3 位作者 Kai Zhang Feng Zhang Shiqing Sun Yu Zhang 《Natural Products and Bioprospecting》 CSCD 2026年第1期212-229,共18页
In this study,a diabetic nephropathy(DN)rat model was established using 2%Streptozocin(STZ)solution,and an in vitro DN model was constructed by stimulating HK-2 cells with 30 mM glucose to investigate the mecha-nism o... In this study,a diabetic nephropathy(DN)rat model was established using 2%Streptozocin(STZ)solution,and an in vitro DN model was constructed by stimulating HK-2 cells with 30 mM glucose to investigate the mecha-nism of Phellodendron amurense Rupr.Polysaccharides(PAP)in ameliorating DN.Results demonstrated that PAP,a neu-tral homogeneous polysaccharide with molecular weight of 1.98 × 105 Da composed of Rha,GalA,Gal,and D-Xyl,exerted renal protective effects through multiple pathways.It enhanced renal antioxidant capacity and alleviated oxidative damage in DN by upregulating PI3K/AKT pathway-related protein expression.Simultaneously,PAP acti-vated theTGF-β/Smad pathway via Nrf2 to mitigate renal fibrosis symptoms in DN,while inhibiting cellular apoptosis.Furthermore,PAP suppressed renal inflammation through gut microbiota reduction,thereby protecting against renal injury in DN rats.This study reveals that PAP alleviates DN symptoms by modulating gut microbiota,enhancing anti-oxidant and anti-fibrotic capacities,and inhibiting apoptotic pathways,comprehensively elucidating its multifaceted therapeutic mechanisms against DN. 展开更多
关键词 Phellodendron amurense Rupr.Polysaccharides Diabetic nephropathy Gut microbiota
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Chemical composition and antioxidant capacity of the aqueous extract of Phellodendron amurense 认领 引用 被引量：4
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作者 Natarajan Velmurugan Duraisamy Kalpana +1 位作者 Jae Young Cho Yang Soo Lee 《Journal of Forestry Research》 SCIE CAS CSCD 2018年第4期1033-1040,共8页
The aqueous extract of Phellodendron amurense Rupr. （Amur Cork Tree） provides a rich source of antioxidants and chemical compounds, and can be used for food and wood preservative materials. In this study, we charact... The aqueous extract of Phellodendron amurense Rupr. （Amur Cork Tree） provides a rich source of antioxidants and chemical compounds, and can be used for food and wood preservative materials. In this study, we characterized the chemical composition of this extract by GC and GC/MS. The antioxidant capacity was evaluated using a variety of antioxidant assays （superoxide radical, hydroxyl radical, nitric oxide radical, and DPPH radical scavenging activity）. Additionally, total polyphenolic content was determined. Phenolic acids and acetone derivatives were major compounds of the extract capable of scavenging the DPPH free radical and reducing ferric ions. DPPH and ferric ion reduction results were strongly correlated with total phenolic content of the extract which also exhibited strong nitric oxide, hydroxyl radical scavenging and superoxide anion radical scavenging activities. 展开更多
关键词 Phellodendron amurense Aqueous extract Chemical characterization Antioxidant activity
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Developmental Morphology of Obturator and Micropyle and Pathway of PollenTube Growth in Ovary in Phellodendron amurense (Rutaceae) 认领 引用 被引量：3
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作者 ZHOU Qing-Yuan JIN Xiao-Bai FU De-Zhi 《Acta Botanica Sinica》 2004年第12期1434-1442,共9页
The developmental morphology of the obturator and micropyle and the pathway of the pollen tubes in the ovarian locule in Phellodendron amurense Rupr.have been investigated by scanning electronmicroscopy and light micr... The developmental morphology of the obturator and micropyle and the pathway of the pollen tubes in the ovarian locule in Phellodendron amurense Rupr.have been investigated by scanning electronmicroscopy and light microscopy.The obturator of the ovule is of funicular origin.As the ovule is fully developed,the obturator becomes considerably large and closely covers the micropyle.When the pistillate flower reaches the receptive phase,the morphology of the obturator is greatly modified,and its cells on the surface are radially expanded and appear to be columnar,semi-papillar or papillar.Following fertilization the obturator reduces in size and degenerates.The pollen tubes need not necessarily traverse the obturator.Whether the pollen tubes pass the obturator or not depends on the sites at which they enter the ovarian locule.This observation does not support the idea that the obturator mainly serves the function of mechanical guidance for the growth of pollen tubes.Our investigations indicate that the structure of themicropyle changes with the different stages of the reproductive process,and becomes asymmetrical during pollination.The development of the obturator and the micropyle correlates with that of the female gametophyte in P.amurense. 展开更多
关键词 developmental morphology micropyle obturator Phellodendron amurense pollen tube pathway
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A new sesterterpenoid from the fruits of Phellodendron chinense var.glabriusculum Schneid 认领 引用 被引量：4
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作者 Chen Yan Ye Wang Xiao Jiang Hao 《Chinese Chemical Letters》 SCIE CAS 2008年第8期937-939,共3页
A new sesterterpenoid phellogine was isolated from the fruits of Phellodendron chinense var. glabriusculum Schneid. Its structure was elucidated on the basis of spectral analysis.
关键词 Phellodendron chinense var. glabriusculum Schneid. Phellogine
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Multiscale analysis of the contents of palmatine in the Nature populations of Phellodendron amurense in Northeast China 认领 引用 被引量：2
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作者 Minglong Sun Lijiao Xu +3 位作者 Yingli Peng Tong Liu Yuhong Zhang Zhiqiang Zhou 《Journal of Forestry Research》 SCIE CAS CSCD 2016年第2期265-272,共8页
Palmatine is a valuable ingredient in Chinese medicine that is produced by Phellodendron amurense Rupr. The contents of palmatine content in root bark, trunk bark, perennial branch bark, annual branches, and leaves of... Palmatine is a valuable ingredient in Chinese medicine that is produced by Phellodendron amurense Rupr. The contents of palmatine content in root bark, trunk bark, perennial branch bark, annual branches, and leaves of the trees with different ages and geographies in Northeast China were measured by high-performance liquid chromatography. The contents of palmatine in the barks of root, trunk, and perennial branch were significantly higher than those in annual branches and leaves. The contents of palmatine in trunk bark and root bark from Lesser Khingan Mountains increased with age, which is significantly opposite to other three vegetation types. The contents of palmatine in perennial branch bark, annual bark and leaves had no significant reg- ularity. Moreover, the contents of palmatine in samples of root bark, trunk bark, perennial branch bark and annual bark varied significantly with latitude. The nature populations of P. amurense growing at low latitude contained significantly more palmatine than those growing at high latitude. These results provide a scientific basis for the reasonable cultivation and efficient utilization of P. amurense. 展开更多
关键词 Content variations Multiscale analysis Palmatine Phellodendron amurense
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Determination of berberine in Phellodendron amurense from different sites of Changbai Mountain 认领 引用 被引量：2
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作者 Lin Ma Jun-qing Li Yuan-dong Hu 《Journal of Forestry Research》 SCIE CAS CSCD 2015年第1期201-207,共7页
Phellodendron amurense has been used for many years as a medical plant in traditional Chinese medicine and has shown great prospect in recent clinical trials for future applications. Berberine is an essential active c... Phellodendron amurense has been used for many years as a medical plant in traditional Chinese medicine and has shown great prospect in recent clinical trials for future applications. Berberine is an essential active compound contained in P. amurense. Our objective in this study was to quantify the content of berberine in P.amurense from sites at different elevations on Changbai Mountain. We collected samples of P. amurense from five different elevations on Changbai Mountain. Berberine in samples was extracted by ultrahigh pressure extraction（UPE）. And the quantity was measured by high performance liquid chromatography（HPLC）. First, the optimal HPLC conditions for berberine were identified with satisfactory precision（relative standard deviation, R SD／5.6 %）, good accuracy（relative error, R E／ 3.6 %） and good linear relation（R2= 0.9998） in the range of 6.576–328.8 mg L-1. Second, the combination of UPE and HPLC methods in quantitative analysis of berberine showed high repeatability（R SD= 3.28 %）, reproducibility（R SD= 4.72 %）,stability（R SD／ 1.27 %） and good recovery（99.54 %） for real plant materials. Samples from Heilongjiang Province at the lowest elevation contained the highest amount of berberine.Similarly, the lowest amount of berberine was recorded in samples from Changbai Forest Bureau of Jilin Province collected at the highest elevation in this paper. The proposed UPE–HPLC method is simple, reliable and low-cost for quantitative analysis of berberine. Content of berberine in P.amurense varied significantly by site on Changbai Mountain. 展开更多
关键词 Phellodendron amurense Berberine Changbai Mountain Altitudes Ultrahigh pressure extraction High performance liquid chromatography
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黄檗(Phellodendron amuranse)叶片总RNA提取方法研究 认领 引用 被引量：8
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作者 祖元刚 王延兵 +1 位作者 王慧梅 孙莲慧 《植物研究》 CAS 北大核心 2007年第5期593-595,共3页
以黄檗(Phellodendron amuranseRupr.)叶片为材料,分别利用改进的盐酸胍法、Trizol法、CTAB法提取黄檗叶片总RNA,通过RNA产率、纯度、电泳图谱等分析,确立了1种从黄檗叶片中快速分离总RNA的方法。研究结果表明,改进盐酸胍法所提取的总RN... 以黄檗(Phellodendron amuranseRupr.)叶片为材料,分别利用改进的盐酸胍法、Trizol法、CTAB法提取黄檗叶片总RNA,通过RNA产率、纯度、电泳图谱等分析,确立了1种从黄檗叶片中快速分离总RNA的方法。研究结果表明,改进盐酸胍法所提取的总RNA的A260/A280为1.928,28S和18S条带清晰谱图完整性好,而且具有产率高、时间短、成本低的特点,所提取的总RNA适用于mRNA分离、cDNA文库的建立、Northern杂交等分析。 展开更多
关键词 黄檗 叶片 RNA 提取
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川黄檗(Phellodendron chinense)适宜区及随气候变化的分布格局模拟 认领 引用 被引量：7
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作者 谢川 余俊里 孙志鹏 《东北林业大学学报》 CAS CSCD 北大核心 2023年第10期54-61,共8页
川黄檗(Phellodendron chinense)具有极高的药用价值,但由于人类干扰和气候变化,导致其野生资源急剧减少,目前已被列为国家Ⅱ级保护野生植物。基于川黄檗的55个有效分布记录点和19个气候因子,利用MaxEnt模型和ArcGIS软件,预测当前(1970... 川黄檗(Phellodendron chinense)具有极高的药用价值,但由于人类干扰和气候变化,导致其野生资源急剧减少,目前已被列为国家Ⅱ级保护野生植物。基于川黄檗的55个有效分布记录点和19个气候因子,利用MaxEnt模型和ArcGIS软件,预测当前(1970—2000年)与未来(2041—2060年和2081—2100年)的潜在分布区格局,并评估制约其地理分布的主要气候因子。研究结果表明:MaxEnt模型预测精度极高,受试者工作曲线面积AUC值大于0.97;川黄檗当前的高适宜以上生境主要覆盖巫山山脉、四川盆地西南边缘山区、贵州中部北部山地以及大巴山南部山区;影响其分布的主要气候因子为年均降水量、年均温、温度季节变化方差和等温性;在未来气候变化情境下,川黄檗的适宜分布区总面积均有不同程度的增加,高适宜以上区域面积呈现出较为明显的波动趋势。降水和温度在塑造川黄檗分布格局上起着重要的作用;相比于当前,川黄檗在未来气候变化条件下的适宜区有向北迁移的趋势,这可为川黄檗野生种质资源保护、利用以及后续研究提供参考。 展开更多
关键词 川黄檗 MaxEnt模拟 地理分布 气候变化
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滤光膜对黄檗(Phellodendron amuranse)幼苗三种生物碱含量的影响 认领 引用 被引量：12
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作者 李霞 阎秀峰 《生态学报》 CAS 北大核心 2009年第3期1292-1299,共8页
以滤光膜遮光处理1年生黄檗(Phellodendron amuranse)幼苗,测定了幼苗生物量及根、茎外皮中的小檗碱、药根碱和掌叶防己碱含量。红色、黄色、蓝色和绿色滤光膜对黄檗幼苗的根和茎生物量都有不同程度的抑制作用,其中黄膜的抑制作用最小,... 以滤光膜遮光处理1年生黄檗(Phellodendron amuranse)幼苗,测定了幼苗生物量及根、茎外皮中的小檗碱、药根碱和掌叶防己碱含量。红色、黄色、蓝色和绿色滤光膜对黄檗幼苗的根和茎生物量都有不同程度的抑制作用,其中黄膜的抑制作用最小,而蓝膜和绿膜的抑制作用最强。滤光膜处理也不同程度地抑制了小檗碱、药根碱和掌叶防己碱的合成和积累,红膜的抑制作用最小,蓝膜和绿膜的抑制作用最强。滤光膜处理后,3种生物碱的单株产量都低于对照,红膜处理小檗碱的产量显著高于黄膜处理,但红膜和黄膜处理下的药根碱和掌叶防己碱的产量差异不显著,蓝膜和绿膜处理的3种生物碱的产量都始终最低。滤光膜处理不利于黄檗幼苗的生长和上述3种生物碱的积累。 展开更多
关键词 滤光膜 黄檗 小檗碱 药根碱 掌叶防己碱
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黄柏(Phellodendron amurense Rupr.)枝条组培快繁技术研究 认领 引用 被引量：6
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作者 苏艳 马双喜 +2 位作者 瞿素萍 彭绿春 王丽花 《西南农业学报》 2008年第6期1679-1681,共3页
以黄柏枝条为外植体,通过研究MS培养基不同激素对黄柏枝条初始萌发的表现,筛选黄柏最佳培养基新配方,结果表明:最适宜黄柏茎段萌动的培养基为MS+6-BA 1.0 mg/L+NAA 0.1 mg/L,最适宜的增殖培养基为MS+6-BA 0.5 mg/L+NAA 0.1mg/L,最适宜... 以黄柏枝条为外植体,通过研究MS培养基不同激素对黄柏枝条初始萌发的表现,筛选黄柏最佳培养基新配方,结果表明:最适宜黄柏茎段萌动的培养基为MS+6-BA 1.0 mg/L+NAA 0.1 mg/L,最适宜的增殖培养基为MS+6-BA 0.5 mg/L+NAA 0.1mg/L,最适宜的生根培养基为MS+NAA 0.3 mg/L+IAA 0.2 mg/L。 展开更多
关键词 黄柏 枝条 组织培养
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Chemical composition and pharmacological activities of the Phellodendron chinense Schneid 认领 引用
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作者 Yi′an Shi Yunpeng Yang +3 位作者 Wenhan Wang Yibo Wan Yao Zhao Yu Chen 《Asian Journal of Traditional Medicines》 2024年第5期285-298,共14页
Phellodendron chinense Schneid(P.chinense),as a traditional Chinese medicine,is commonly used in clinical practice.It has the effects of drying dampness,clearing heat,detoxifying,purging fire,and reducing swelling.Its... Phellodendron chinense Schneid(P.chinense),as a traditional Chinese medicine,is commonly used in clinical practice.It has the effects of drying dampness,clearing heat,detoxifying,purging fire,and reducing swelling.Its main chemical components are flavonoids and alkaloids,which have various pharmacological effects such as lowering blood sugar,lowering blood pressure and immunosuppression.With the continuous development of modern science and technology,the research on P.chinense Schneid has increased.This study reviews the chemical components and pharmacological effects of P.chinense Schneid,and provides reference for its further research and development. 展开更多
关键词 Phellodendron chinense Schneid chemical composition pharmacological activity
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Study on Anti-gout Effect of Phellodendron amurense and Its Processed Products 认领 引用
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作者 Lian LIAN 《Agricultural Biotechnology》 2018年第4期203-205,共3页
[Objectives] This study was conducted to study the anti-gout effect of Phellodendron amurense and its different processed products.[Methods] Extracts of P. amurense and its different processed products were fed to rat... [Objectives] This study was conducted to study the anti-gout effect of Phellodendron amurense and its different processed products.[Methods] Extracts of P. amurense and its different processed products were fed to rats respectively, to observe uric acid and creatinine in the serum and swelling index.[Results] Compared with the data of positive control, P. amurense and the processed products could significantly reduce the high uric acid and creatinine in the serum, and also could resist the swelling in rats.[Conclusions] P. amurense and its processed products showed different degrees of anti-gout effect, and the processing methods were found to have no remarkable impact on this effect. 展开更多
关键词 Phellodendron amurense Anti-gout effect Processed products Hyperuricemia
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Study on Chemical Constituents from Phellodendron chinense 认领 引用
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作者 Lian LIAN Xiaoyan XIAN +2 位作者 Donghai CHU Weili JIA Huiyuan GAO 《Medicinal Plant》 2023年第2期5-7,共3页
[Objectives]To isolate and identify chemical constituents from Phellodendron chinense.[Methods]Compounds were isolated by silica gel,Sephadex LH-20,and ODS column chromatography,and their structures were determined by... [Objectives]To isolate and identify chemical constituents from Phellodendron chinense.[Methods]Compounds were isolated by silica gel,Sephadex LH-20,and ODS column chromatography,and their structures were determined by means of the spectral analysis and physicochemical properties.[Results]Eleven compounds were isolated and identified as berberine(1),obaculactone(2),shihulimonin A(3),N-p-coumaroyltyramine(4),1-(4-hydroxy-3-methoxyphenyl)-2-[4-(3-hydroxy-propyl)-2-methoxyphenoxy]-propane-1,3-diol(5),phellodendrine(6),magnoflorine(7),palmatine(8),jatrorrhizine(9),columbamine(10),and obacunone(11).[Conclusions]Compounds 3 and 5 were isolated from Phellodendron for the first time,and compound 4 was isolated from this plant for the first time. 展开更多
关键词 Phellodendron chinense Chemical constituents Structural identification Isolated for the first time
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Metabolome and transcriptome association study reveals biosynthesis of specialized benzylisoquinoline alkaloids in Phellodendron amurense 认领 引用 被引量：2
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作者 Tingxia Liu Wanran Zhang +7 位作者 Sijia Wang Ya Tian Yifan Wang Ranran Gao Shilin Chen Wei Sun Wei Ma Zhichao Xu 《Chinese Herbal Medicines》 CAS CSCD 2025年第1期178-188,共11页
Objective:Benzylisoquinoline alkaloids(BIAs)have pharmacological functions and clinical use.BIAs are mainly distributed in plant species across the order Ranunculales and the genus Phellodendron from Sapindales.The BI... Objective:Benzylisoquinoline alkaloids(BIAs)have pharmacological functions and clinical use.BIAs are mainly distributed in plant species across the order Ranunculales and the genus Phellodendron from Sapindales.The BIA biosynthesis has been intensively investigated in Ranunculales species.However,the accumulation mechanism of BIAs in Phellodendron is largely unknown.The aim of this study is to unravel the biosynthetic pathways of BIAs in Phellodendron amurens.Methods:The transcriptome and metabolome data from 18 different tissues of P.amurense were meticulously sequenced and subsequently subjected to a thorough analysis.Weighted gene co-expression network analysis(WGCNA),a powerful systems biology approach that facilitates the construction and subsequent analysis of co-expression networks,was utilized to identify candidate genes involved in BIAs biosynthesis.Following this,recombinant plasmids containing candidate genes were expressed in Escherichia coli,a widely used prokaryotic expression system.The purpose of this genetic engineering endeavor was to express the candidate genes within the bacteria,thereby enabling the assessment of the resultant enzyme activity.Results:The synonymous substitutions per synonymous site for paralogs indicated that at least one whole genome duplication event has occurred.The potential BIA biosynthetic pathway of P.amurense was proposed,and two PR10/Bet v1 members,14 CYP450s,and 33 methyltransferases were selected as related to BIA biosynthesis.One PR10/Bet v1 was identified as norcoclaurine synthase,which could catalyze dopamine and 4-hydroxyphenylacetaldehyde into(S)-norcoclaurine.Conclusion:Our studies provide important insights into the biosynthesis and evolution of BIAs in nonRanunculales species. 展开更多
关键词 benzylisoquinoline alkaloids biosynthesis evolution norcoclaurine synthase Phellodendron amurense Rupr
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Inhibitory Effect of the Extract of Phellodendron amurense Ruprecht Root on Collagen-Induced Arthritis in Mice 认领 引用 被引量：12
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作者 Hyo Won Jung Kyung-Ho Kim Yong-Ki Park 《Chinese Journal of Integrative Medicine》 SCIE CAS CSCD 2017年第10期755-762,共8页
Objective： To investigate whether the dried root of Phellodendron amurense Ruprecht（Phellodendri cortex; PC） extract improves arthritic symptoms through anti-inflammatory and immune-modulatory effects in collagen-i... Objective： To investigate whether the dried root of Phellodendron amurense Ruprecht（Phellodendri cortex; PC） extract improves arthritic symptoms through anti-inflammatory and immune-modulatory effects in collagen-induced arthritis in mice. Methods： Rheumatoid arthritis（RA） was induced in male DBA/1 mice by immunization with type Ⅱ collagen（ColⅡ）. CIA mice were divided into 5 groups（n=10 per a group） with normal, CIA control, PC extract（50 mg/kg and 100 mg/kg）-treated, and meloxicam（50 mg/kg）-treated as the reference drug. The PC extract or meloxicam were administered orally in CIA mice once a day for 14 days after arthritis induction. Arthritic score, levels of anti-ColⅡ IgG2a antibody, prostaglandin E2（PGE2）, tumor necrosis factor（TNF）-α, and interleukin（IL）-17 in the sera of CIA mice were measured. Histopathological changes in the ankle joints of CIA mice were also analyzed by staining with hematoxylin and eosin（H and E）, safranin-O and immunohistochemistry using anti-TNF-α and anti-IL-17 antibodies. Results： The arthritic score was increased in CIA mice in a time-dependent manner, as were the serum levels of anti-ColⅡ IgG2a antibody, PGE2, TNF-α, and IL-17. However, the oral administration of PC extract at 50 and 100 mg/kg in CIA mice significantly decreased the arthritic scores, and the serum levels of anti-ColⅡ IgG2a, PGE2, TNF-α, and IL-17 compared with those in the CIA group（P〈0.05 or P〈0.01）. Furthermore, histopathological improvement of the joint architecture in CIA mice was observed after administration of PC extract. PC extract also significantly inhibited the expression of TNF-α and IL-17 in the joints of CIA mice by suppressing the expression of their m RNA and proteins. Conclusion： PC extract may improve the pathological progression of RA through the inhibition of joint destruction by synovial inflammation and immune-stimulation, therefore, it would be a potential anti-arthritic agent in RA. 展开更多
关键词 Phellodendron amurense Phellodendri cortex collagen-induced arthritis anti-arthritic effect
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不同剂型黄柏提取物对球虫和产气荚膜梭菌联合感染肉仔鸡的治疗效果评价 认领 引用
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作者 郑琳 张建建 魏炳栋 《动物营养学报》 CAS CSCD 北大核心 2026年第3期1935-1950,共16页
本试验旨在探究不同剂型黄柏提取物对球虫和产气荚膜梭菌联合感染肉仔鸡生长性能、抗氧化指标、细胞因子、回肠形态结构及盲肠菌群的影响,以明确不同剂型黄柏提取物对肉鸡坏死性肠炎的作用功效。选取健康且体重相近的1日龄艾拔益加肉仔... 本试验旨在探究不同剂型黄柏提取物对球虫和产气荚膜梭菌联合感染肉仔鸡生长性能、抗氧化指标、细胞因子、回肠形态结构及盲肠菌群的影响,以明确不同剂型黄柏提取物对肉鸡坏死性肠炎的作用功效。选取健康且体重相近的1日龄艾拔益加肉仔鸡120只,随机分为5组,分别为对照组(C组)、攻毒组(CI组)、黄柏提取物治疗组(CIP组)、肠溶缓释黄柏提取物治疗组(CIESP组)和抗生素治疗组(CIA组),每组6个重复,每个重复4只鸡。试验期20 d,其中预试期3 d,正试期17 d[分为攻毒期(4~9日龄)与治疗期(10~20日龄)]。攻毒期,除C组外其余各组肉仔鸡在4~6日龄时每天灌服1 mL鸡球虫卵囊悬液(33000个孢子囊/mL),7~9日龄时每天灌服1 mL产气荚膜梭菌CP4菌液(1×109 CFU/mL),C组肉仔鸡每天灌服1 mL生理盐水。1~9日龄时各组均饲喂基础饲粮,10~20日龄时,C组和CI组饲喂基础饲粮,CIP组饲喂基础饲粮+0.1 g/kg黄柏提取物,CIESP组饲喂基础饲粮+40 g/kg肠溶缓释黄柏提取物,CIA组饲喂基础饲粮+4 g/kg恩拉霉素预混剂。结果表明:1)CIP组4~21日龄料重比(F/G)显著高于C组和CIESP组(P0.05),CIA组盲肠放线菌门(Actinobacteria)相对丰度极显著高于其余4组(P<0.01),CIESP组盲肠瘤胃球菌科_瘤胃球菌属(Ruminococcaceae_Ruminococcus)相对丰度显著高于C组、CI组和CIP组(P<0.05),CIP组和CIESP组盲肠丁酸球菌属(Butyricicoccus)相对丰度显著高于C组(P<0.05)。综上所述,肠溶缓释黄柏提取物能够有效降低球虫和产气荚膜梭菌联合感染导致的肉仔鸡促炎因子含量升高,修复回肠组织形态损伤,提升其抗氧化能力,并能改变盲肠菌群结构。 展开更多
关键词 黄柏提取物 产气荚膜梭菌 球虫 肉仔鸡 生长性能 抗氧化 肠道健康
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糖尿病皮肤创面模型小鼠正交实验优选“红黄白”凝胶的处方配比 认领 引用
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作者 高艳果 郭旭 +8 位作者 李晓晗 陈仕琦 朱海涛 黄良永 叶方 卢伟 王启斌 郑涛 陈黎 《中国组织工程研究》 CAS 北大核心 2026年第8期1921-1928,共8页
背景:中药外治法在促创面愈合方面有着悠久的历史,开发有效的中药外用制剂治疗糖尿病足溃疡具有重要意义。“红黄白(红景天、黄柏、白及)”组方药材具有去腐生肌、活血通络和解毒疗疮等功效,可有效促进糖尿病足溃疡愈合,但实际应用中存... 背景:中药外治法在促创面愈合方面有着悠久的历史,开发有效的中药外用制剂治疗糖尿病足溃疡具有重要意义。“红黄白(红景天、黄柏、白及)”组方药材具有去腐生肌、活血通络和解毒疗疮等功效,可有效促进糖尿病足溃疡愈合,但实际应用中存在久置易分层、换药时不易清理等缺陷。目的:优选“红黄白”凝胶的处方配比,开发稳定性良好、具有促糖尿病足溃疡愈合作用的凝胶型制剂。方法:通过腹腔注射链脲佐菌素的方法建立C57BL/6J小鼠糖尿病模型,造模成功4周后在小鼠背部制作直径8 mm的全层皮肤缺损创面,以“红黄白”凝胶组方药材(白及6-15 g、红景天3-6 g和黄柏3-12 g)的用量为考察因素,以创面愈合率及其曲线下面积为评价指标进行L9(34)正交实验,优选“红黄白”凝胶处方的配比。将30只C57BL/6J小鼠随机分为正常对照组、模型对照组和最佳处方配比药物治疗组(平行3组),每组6只,正常对照组制作全层皮肤缺损,模型对照组制作糖尿病全层皮肤缺损,最佳处方配比药物治疗组制作糖尿病全层皮肤缺损,创面造模3 d后,正常对照组、模型对照组创面涂抹灭菌水,最佳处方配比药物治疗组创面涂抹最佳处方配比“红黄白”凝胶处方,1次/d,连续治疗12 d,以创面愈合率及其曲线下面积为评价指标验证正交实验结果。结果与结论:正交实验结果显示,“红黄白”凝胶的最佳处方配比为白及6 g、红景天4.5 g、黄柏12 g;验证实验结果显示,最佳处方配比药物治疗组小鼠第4,6天的创面愈合率及其曲线下面积均高于模型对照组。结果表明“红黄白”凝胶的最佳处方配比为白及6 g、红景天4.5 g、黄柏12 g,此处方可有效促进糖尿病小鼠皮肤创面愈合。 展开更多
关键词 红黄白凝胶 红景天 黄柏 白及 正交实验 处方配比 糖尿病足溃疡 愈合率 工程化皮肤材料
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复方黄柏液涂剂治疗阴道炎和会阴伤口感染临床应用专家共识(2025年版) 认领 引用
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作者 李军 门傲雪 薛晓鸥 《中国新药杂志》 CAS CSCD 北大核心 2026年第5期538-545,共8页
复方黄柏液涂剂于1995年上市,兼具抗炎、促修复、调节免疫作用,在临床上可用于妇科多种阴道炎症及会阴伤口感染的治疗,具有较好的临床疗效。为进一步规范复方黄柏液涂剂治疗阴道炎和会阴伤口感染的临床应用,本学会组织相关领域专家撰写... 复方黄柏液涂剂于1995年上市,兼具抗炎、促修复、调节免疫作用,在临床上可用于妇科多种阴道炎症及会阴伤口感染的治疗,具有较好的临床疗效。为进一步规范复方黄柏液涂剂治疗阴道炎和会阴伤口感染的临床应用,本学会组织相关领域专家撰写本共识。在结合循证证据和专家临床经验的基础上,拟解决复方黄柏液涂剂治疗阴道炎、会阴伤口感染的临床疗效及用法用量等临床问题。 展开更多
关键词 复方黄柏液涂剂 阴道炎 会阴伤口感染 专家共识
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复方黄柏液涂剂联合荆防颗粒在宫颈人乳头瘤病毒感染患者中的应用效果 认领 引用
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作者 宋淑慧 喻小燕 吴懿 《中国当代医药》 CAS 2026年第3期54-57,62,共4页
目的分析复方黄柏液涂剂联合荆防颗粒在宫颈人乳头瘤病毒(HPV)感染患者中的应用效果。方法选取2024年1月至2025年1月上饶市人民医院妇产科收治的120例宫颈HPV感染患者作为研究对象,按照随机数字表法将其分为对照组和试验组,每组各60例,... 目的分析复方黄柏液涂剂联合荆防颗粒在宫颈人乳头瘤病毒(HPV)感染患者中的应用效果。方法选取2024年1月至2025年1月上饶市人民医院妇产科收治的120例宫颈HPV感染患者作为研究对象,按照随机数字表法将其分为对照组和试验组,每组各60例,对照组采用荆防颗粒治疗,试验组采用复方黄柏液涂剂联合荆防颗粒治疗。比较两组治疗总有效率、临床症状缓解情况以及治疗前后病毒负荷量、症状缓解时间、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)、免疫球蛋白A(IgA)、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)水平的变化。结果试验组患者阴道分泌物增多、腰酸、尿痛、瘙痒缓解时间早于对照组,差异有统计学意义(P<0.05)。试验组治疗后IgG、IgM、IgA水平高于对照组,差异有统计学意义(P<0.05)。试验组治疗后的TNF-α、IL-6、IL-10水平与病毒负荷量低于对照组,差异有统计学意义(P<0.05)。试验组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。结论采用复方黄柏液涂剂联合荆防颗粒治疗宫颈HPV感染,可有效缓解患者阴道分泌物增多、瘙痒等临床症状,增强机体免疫功能,降低体内炎症因子水平和病毒负荷量。 展开更多
关键词 宫颈人乳头瘤病毒感染 复方黄柏液涂剂 荆防颗粒 炎症因子 病毒负荷量
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黄檗优树选择与评价 认领 引用
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作者 张丽艳 马晓雨 +4 位作者 高源 尚福强 于洪亮 程彦博 苏蕾 《辽宁林业科技》 2026年第2期20-24,共5页
黄檗是辽宁省珍贵阔叶树种,兼具材用、药用与生态价值。目前其天然资源稀缺、群体性状分化显著,种质创新与综合开发利用均受到制约。为明确黄檗优树核心经济性状特征,建立科学的优树评选体系,推动种质资源保护、遗传改良与高效开发利用... 黄檗是辽宁省珍贵阔叶树种,兼具材用、药用与生态价值。目前其天然资源稀缺、群体性状分化显著,种质创新与综合开发利用均受到制约。为明确黄檗优树核心经济性状特征,建立科学的优树评选体系,推动种质资源保护、遗传改良与高效开发利用,对辽宁省4个分布地点的27株黄檗优树的主要经济性状进行了测定与分析。筛选出9株材用型优树,优树胸径均值高出初选群体的16.60%,材积均值高出初选群体的36.42%;5株药用型优树,优树小檗碱含量最高为19.86 mg·g-1,其中包含材药兼用型优树3株,优树号分别为2310,2320和2322。该研究结果可为辽宁省黄檗的综合开发与种质创新提供参考依据。 展开更多
关键词 黄檗 材用型 药用型 优树选择
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