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High-fidelity gut metagenome:A new insight of identification of fuctional probiotics 认领 引用 被引量：1
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作者 Yuhui Wang Peiwen Gao +4 位作者 Chenying Li Yuxi Lu Yubo Zhang Yu Zhou Siyuan Kong 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2026年第4期1330-1342,共13页
Probiotics are considered to exert beneficial effects in humans and animals by modulating the structure and metabolic functions of the gut microbiota.Therefore,the identification of functional probiotics and in-depth ... Probiotics are considered to exert beneficial effects in humans and animals by modulating the structure and metabolic functions of the gut microbiota.Therefore,the identification of functional probiotics and in-depth exploration of the characteristics and applicability of probiotics are of paramount significance for the development of more effective probiotic products and the formulation of personalized probiotic treatment strategies in the fields of human health and livestock farming.However,due to current limitations in sequencing technologies and considering that microbial communities may encompass closely related lineages,rendering metagenome assembly complex,the generation of complete metagenomeassembled genomes(c MAGs)is hindered.This limitation constrains our comprehensive resolution at the probiotic strain level.In this review,we summarized the effects of probiotics on gut microbiota balance and host health from a functional perspective.The technical methods of functional probiotics identification were summarized from the technical point of view.Furthermore,we introduced methods for microbial metagenome assembly to elucidate the associated progress and advantages and disadvantages of these approaches.Finally,we highlight more advanced metagenomic assembly techniques that may help us assemble high-fidelity intestinal metagenomes,providing powerful tools for the identification of functional probiotics. 展开更多
关键词 host health gut microbiota probiotics gut metagenome metagenomic assembly
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The engineered probiotic strain Lactococcus lactis MG1363-pMG36e-GLP-1 regulates microglial polarization and gut dysbiosis in a transgenic mouse model of Parkinson’s disease 认领 引用 被引量：2
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作者 Mengyun Yue Tingtao Chen +6 位作者 Wenjie Chen Jing Wei Bin Liao Jie Zhang Fangjun Li Daojun Hong Xin Fang 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第3期1211-1221,共11页
Parkinson’s disease is characterized by synucleinopathy-associated neurodegeneration.Previous studies have shown that glucagon-like peptide-1(GLP-1)has beneficial effects in a mouse model of Parkinson’s disease indu... Parkinson’s disease is characterized by synucleinopathy-associated neurodegeneration.Previous studies have shown that glucagon-like peptide-1(GLP-1)has beneficial effects in a mouse model of Parkinson’s disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.However,the effect of GLP-1 on intrinsic synuclein malfunction remains unclear.In this study,we investigated the effect of Lactococcus lactis MG1363-pMG36e-GLP-1 on parkinsonism in SncaA53T transgenic mice and explored the underlying mechanisms.Our data showed that Lactococcus lactis MG1363-pMG36e-GLP-1 inhibited dopaminergic neuronal death,reduced pathological aggregation ofα-synuclein,and decreased movement disorders in SncaA53T transgenic mice.Furthermore,Lactococcus lactis MG1363-pMG36e-GLP-1 downregulated lipopolysaccharide-related inflammation,reduced cerebral activation of microglia and astrocytes,and promoted cell survival via the GLP-1 receptor/PI3K/Akt pathway in the substantia nigra.Additionally,Lactococcus lactis MG1363-pMG36e-GLP-1 decreased serum levels of pro-inflammatory molecules including lipopolysaccharide,lipopolysaccharide binding protein,interleukin-1β,and interleukin-6.Gut histopathology and western blotting further revealed that Lactococcus lactis MG1363-pMG36e-GLP-1 increased the expression of gut integrity-related proteins and reduced lipopolysaccharide-related inflammation by reversing gut dysbiosis in SncaA53T transgenic mice.Our findings showed that the beneficial effect of Lactococcus lactis MG1363-pMG36e-GLP-1 on parkinsonism traits in SncaA53T transgenic mice is mediated by microglial polarization and the reversal of dysbiosis.Collectively,our findings suggest that Lactococcus lactis MG1363-pMG36e-GLP-1 is a promising therapeutic agent for the treatment of Parkinson’s disease. 展开更多
关键词 A53T transgenic mice engineered probiotics glucagon-like peptide-1 gut dysbacteriosis gut-brain axis Lactococcus lactis MG1363-pMG36e-GLP-1 microglial polarization neurodegenerative disease neuroinflammation Parkinson’s disease
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Probiotics is riding high:effects of gut microbiota on skin health 认领 引用
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作者 Zheyi Song Renyi Song +2 位作者 Lan Lan Kejun Cheng Xin Zhang 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第5期1965-1975,共11页
The human skin is one of the largest epithelial surfaces that can resist external damage and protect against the external environment.The intricate connection between the skin and the gut has been shown by recent rese... The human skin is one of the largest epithelial surfaces that can resist external damage and protect against the external environment.The intricate connection between the skin and the gut has been shown by recent research.The homeostasis of gut microbiota impacts skin conditions,while the dysbiosis of microbiota may destroy mucosal immune tolerance and exacerbate skin inflammation.Moreover,the term gut-brain-skin axis has gradually attracted much interest from researchers.Emotional states including stress,depression,and anxiety will change the gut microbiota,trigger the inflammatory response,and negatively impact skin health.Numerous skin issues have been found to be improved by probiotics,including oxidative stress reduction,immune response regulation,and enhanced skin barrier function This paper attempts to show the significance of gut microbiota on skin disorders and the connection signaling of the gut-brain-skin axis.Additionally,by summarizing the mechanism of probiotic usage in improving skin health,we also provide a mathematical foundation for the use of probiotics in skin health. 展开更多
关键词 Skin Skin diseases Gut microbiota Probiotics Gut-skin axis Gut-brain-skin axis
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Hybrid Probiotic Hydrogel With Curcumin-Loaded MnO2Nanoparticles Enhances Diabetic Wound Healing Through Multimodal Microenvironmental Regulation 认领 引用
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作者 Xianfeng Wang Yuwen Shangguan +4 位作者 Hao Nan Lingze Chen Chencheng Gu Litao Yan Huan Li 《Rare Metals》 SCIE EI CAS CSCD 2026年第3期407-421,共15页
Skin wound injuries are often accompanied by bacterial infections and severe inflammation.Especially,M1-type macrophages at the wound site can trigger a cascade of inflammatory responses,mediating a vicious cycle of i... Skin wound injuries are often accompanied by bacterial infections and severe inflammation.Especially,M1-type macrophages at the wound site can trigger a cascade of inflammatory responses,mediating a vicious cycle of inflammation.Meanwhile,hypoxia further exacerbates vascular damage and constriction in the wound microenvironment,thereby impeding the healing process of infected wounds.To address this,we propose a"trinity"strategy integrating skin microbiota homeostasis regulation,immune microenvironment remodeling,and oxygen generation to promote blood flow for wound repair.A thermos-sensitive hydrogel was utilized to deliver nano-hybridized probiotics(LGG@NP-Gel).The hybrid probiotics were constructed by modifying Lactobacillus rhamnosus GG(LGG)with curcumin-loaded manganese dioxide.LGG exerts antibacterial effects through acid secretion and bioantagonism while promoting M2 macrophage polarization.The HMnO2component releases curcumin,further enhancing M2 macrophage polarization.Additionally,HMnO2scavenges reactive oxygen species(ROS)and generates oxygen,improving local oxygenation and blood supply to accelerate wound healing.In a murine wound model,LGG@NP-Gel significantly enhanced the healing efficacy. 展开更多
关键词 macrophage polarization nano-hybridized probiotics reactive oxygen species skin microbiota wound healing
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Probiotic supplementation in men with asthenozoospermia: A randomized controlled trial 认领 引用
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作者 Ghazaleh Moshkdanian Mina Toghraiee +2 位作者 Hassan Hassani Bafrani Fatemeh Zahra Ahaz Hamed Haddad Kashani 《Asian pacific Journal of Reproduction》 CAS 2026年第2期67-74,共8页
Objective:To investigate the potential of oral probiotics to improve sperm motility and decrease DNA fragmentation in men diagnosed with asthenozoospermia.Methods:Men diagnosed with asthenozoospermia,aged between 18 a... Objective:To investigate the potential of oral probiotics to improve sperm motility and decrease DNA fragmentation in men diagnosed with asthenozoospermia.Methods:Men diagnosed with asthenozoospermia,aged between 18 and 40 years,were randomly assigned to receive probiotic or placebo for 10 weeks.Sperm parameters(count,motility,and morphology)and seminal fluid biochemical markers were assessed using light microscopy and Diff-Quik staining.Intracellular reactive oxygen species levels were measured using the malondialdehyde(MDA)technique,while DNA fragmentation index(DFI)was evaluated through acidic aniline blue staining.Data from both groups were compared to determine the effects of probiotic supplementation.Results:Sixteen men were included.The probiotic group(n=8)showed a significant increase in total sperm motility(P<0.001)and progressive motility(P=0.003)compared to the placebo group(n=8).Additionally,sperm count in the probiotic group was significantly higher than in the placebo group,although other sperm parameters did not show significant changes.Notably,levels of MDA(P=0.027)and DFI(P=0.004)were significantly reduced in the probiotic group,indicating a decrease in oxidative stress and DNA damage.Conclusions:Probiotic supplementation effectively enhances sperm quality by mitigating oxidative stress and reducing DNA damage,thereby improving sperm motility in men with asthenozoospermia.Study registration:The trial was registered with the Iranian Registry of Clinical Trials(IRCT20220119053769N1). 展开更多
关键词 Sperm quality Probiotics Reactive oxygen species Asthenozoospermia Antioxidant DNA damage Infertility
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Probiotics,gut microbiota and physical activity:A close relationship 认领 引用
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作者 Ioannis Alexandros Charitos Marica Colella +1 位作者 Domenico Maria Carretta Luigi Santacroce 《Sports Medicine and Health Science》 CAS CSCD 2026年第1期43-49,共7页
Background:The topic of this review is the study of the gut microbiota(GM),and the use of probiotics,especially in humans,as a new frontier in the field of prevention and health in general.The beneficial effects and f... Background:The topic of this review is the study of the gut microbiota(GM),and the use of probiotics,especially in humans,as a new frontier in the field of prevention and health in general.The beneficial effects and functions performed by probiotics in the GM are increasingly at the centre of both scientific,medical,and pharmaceutical interest.It is now known that diet and probiotics can modify the GM,although in these situations there is a need for greater and more in-depth research regarding the methods and timing of treatment.However,the relationship between physical activity,GM,and probiotics is still largely unclear,as regards certain mechanisms between physical exercise and probiotics in humans.Discussion:In this study,we tried to demonstrate whether and how physical exercise was able to alter the composition of the microbiota and how probiotics can facilitate it.Therefore,alteration of the microbiota was considered in terms of both diversity and composition.Conclusions:The ones examined propose vastly different physical exercises,both in terms of timing and type of intervention itself,and the use of probiotics. 展开更多
关键词 Physical exercise Probiotics Gut microbiota Obesity Gut/muscle axis Gut/brain axis
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Letter to the Editor:Probiotics counteract polyethylene glycol bowel preparation dysbiosis and infection risk 认领 引用
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作者 Yang Fu 《World Journal of Gastroenterology》 SCIE CAS 2026年第28期157-160,F0003,共4页
Polyethylene glycol(PEG)bowel preparation,though widely used,can significantly disrupt gut microbiota composition.Kou et al recently published study in the World Journal of Gastroenterology,which demonstrated that PEG... Polyethylene glycol(PEG)bowel preparation,though widely used,can significantly disrupt gut microbiota composition.Kou et al recently published study in the World Journal of Gastroenterology,which demonstrated that PEG-treated mice challenged with Citrobacter rodentium exhibit higher pathogen loads,elevated virulence gene expression,and worsened colitis,mediated by microbiota dysbiosis.Importantly,Lactobacillus acidophilus supplementation restored microbial balance and mitigated infection severity,suggesting PEG-induced loss of colonization resistance exposes a 14-day infection window.This paradigm aligns with a rare human case of septic shock after PEG bowel preparation,highlighting potential opportunistic infection risk.Probiotic Lactobacillus strengthen the epithelial barrier and modulate immunity,and clinical trials support their efficacy and safety in gastrointestinal contexts.We discuss the translational significance of these findings and advocate microbiota-protective strategies(probiotic supplementation,optimal timing of endoscopy,and dietary adjustments)during bowel preparation. 展开更多
关键词 Polyethylene glycol Bowel preparation Dysbiosis Citrobacter rodentium Probiotics Colonoscopy Infection risk
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Interrelations between probiotics,gut microbiota,intestinal barrier,and immune response focusing on diarrhea in dairy calves 认领 引用 被引量：1
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作者 Munwar Ali Chang Xu +2 位作者 Qazal Hina Aoyun Li Kun Li 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2026年第1期16-29,共14页
The interplay between gut microbiota and host health has attracted significant interest in the animal science community.Maintaining gut microbiota homeostasis by supplementing probiotics to treat clinical conditions l... The interplay between gut microbiota and host health has attracted significant interest in the animal science community.Maintaining gut microbiota homeostasis by supplementing probiotics to treat clinical conditions like calf diarrhea is an emerging area of research nowadays because of increased concerns regarding antimicrobial resistance(AMR)and drug residues in animal products.Probiotics reduce the incidence of calf diarrhea by increasing the gut microbiota diversity and richness with more commensal bacteria such as Lactobacillus and Bifidobacterium that produce antimicrobial compounds,as well as modulating the immune response by increasing cytokines,Interleukin-2(IL-2),IL-4,IL-6,IL-10,and reducing tumor necrosis factor-α(TNF-α),by increasing production of antibodies,especially immunoglobulin E(Ig E),also Ig G,differentiating naive Th lymphocytes(Tho)into Th1,hence stimulate innate immunity and prime the adaptive immune response.Specific probiotic strains of bacteria and yeast(Saccharomyces cerevisiae)derived probiotics maintain the integrity of the intestinal barrier.In this review,data are being organized to address the role of probiotics in treating calf diarrhea by modulating gut microbiota and stimulating an immune response against notorious pathogens,to present animal and veterinary scientists and nutritionists with a new concept to treat infectious diseases from the perspective of the gut microbiota,increasing animal health,performance,and welfare.In conclusion,health status and gut microbiome are strongly interlinked.Research data indicated a significant reduction in the incidence of diarrhea after probiotic administration.If interrelations between probiotics and existing gut microbiota are explored more quantitatively,novel antibiotic substitutes can emerge in the future. 展开更多
关键词 probiotics gut microbiota diarrhea calves intestinal barrier immune response
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Probiotics in colorectal cancer:mechanisms,biomarkers,and adjunct strategies 认领 引用
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作者 Zihe Xu Lan Mu +6 位作者 Hao Su Xiaoting Zhang Haiyun Shang Zhuotian Li Matthew Tak Vai Chan William Ka Kei Wu Huarong Chen 《Cancer Biology & Medicine》 SCIE CAS CSCD 2026年第5期596-614,共19页
Colorectal cancer(CRC)is among the most common malignant tumors and remains a leading cause of cancer-related mortality worldwide.The gut microbiota and metabolites,which are modulated by host genetics and environment... Colorectal cancer(CRC)is among the most common malignant tumors and remains a leading cause of cancer-related mortality worldwide.The gut microbiota and metabolites,which are modulated by host genetics and environmental exposures,have emerged as key contributors to the pathogenesis of CRC.A key feature of gut dysbiosis in CRC is the enrichment of pathogenic bacteria alongside the depletion of beneficial commensals.Probiotic supplementation has been shown to counteract this imbalance and suppress tumor progression.Mechanistically,probiotics suppress CRC development through multifaceted actions,including directly inhibiting tumor cell growth,reducing inflammation,reinforcing the intestinal barrier,and reprogramming host immunity.This review summarizes evidence on the inhibitory role of probiotics in CRC,evaluates the potential of probiotics as predictive biomarkers,and discusses microbiome-modulation strategies designed to enhance immunotherapy and chemotherapy,thereby offering a complementary paradigm for CRC prevention and treatment. 展开更多
关键词 Colorectal cancer probiotics mechanism biomarker therapy
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Characterization and genomic evaluation of probiotic potential,safety,and aquaculture applicability of Enterococcus faecalis SZ07 isolated from Trachinotus ovatus intestine in vitro 认领 引用
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作者 Xiao Zhang Jia Cai +6 位作者 Liqun Wang Yi Li Yu Huang Dapeng Yu Bei Wang Jichang Jian Huapu Chen 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2026年第4期164-181,共18页
To assess the probiotic potential,safety,and application value of Enterococcus faecalis SZ07(isolated from the intestine of Trachinotus ovatus)in aquaculture,this study combined phenotypic assays and genomic analysis.... To assess the probiotic potential,safety,and application value of Enterococcus faecalis SZ07(isolated from the intestine of Trachinotus ovatus)in aquaculture,this study combined phenotypic assays and genomic analysis.The strain exhibited typical probiotic-related phenotypes including environmental stress tolerance,intestinal adhesion ability,and antimicrobial activity against aquatic pathogens.Genomic analysis confirmed that SZ07 does not carry key virulence genes,but contains gene clusters involved in the synthesis of probiotic secondary metabolites;it also shared functional similarity with the probiotic strain E.faecalis Symbioflor 1,while displaying marked differences from the pathogenic strain E.faecalis V583.Although E.faecalis SZ07 carried some resistance genes,it remained sensitive to vancomycin,and this carriage did not impair its probiotic functions in vitro.The unique adaptability of this marine-derived strain lays a foundation for its application in aquaculture. 展开更多
关键词 Enterococcus faecalis SZ07 probiotic potential genomic analysis aquaculture safety
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Research advances in the immunomodulatory mechanisms of probiotics on non-specific and specific immunity 认领 引用
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作者 Haijie Zhao Hongxuan Li +8 位作者 Yiqing Zhao Tong Wu Yiling Deng Yanmei Hou Wei Zhang Chaoxin Man Yu Zhang Qianyu Zhao Yujun Jiang 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第2期473-488,共16页
Probiotics can regulate the body’s immune system through both non-specific and specific immunity,thereby regulating host health.In terms of non-specific immune regulation,probiotics can activate the intrinsic immune ... Probiotics can regulate the body’s immune system through both non-specific and specific immunity,thereby regulating host health.In terms of non-specific immune regulation,probiotics can activate the intrinsic immune system,regulate the mucosal barrier function,and play an immune role by influencing the activity of intrinsic immune cells such as macrophages,dendritic cells and natural killer cells,as well as their differentiation and maturation;in terms of specific immune regulation,probiotics play a role in regulating the immunoglobulin level and the maturation of B cells.Probiotics can also regulate T-cell differentiation according to the condition of the body,thus regulating specific immunity.Many studies have focused on the role of probiotics in metabolism and nutrition,and the mechanisms involved in the immunomodulatory role of probiotics have only been partially described.This review summarises the role of common probiotics such as Lactobacillus plantarum and Lactobacillus rhamnosus in immunomodulation as well as their mechanisms,describing the currently known mechanisms of immunomodulation by probiotics in improving the host immune system.A deeper understanding of probiotics and their specific mechanisms of action will facilitate the use of probiotics for immunomodulation in clinical medicine,functional foods,and other areas.This will also contribute to the development and research of engineered probiotics,next-generation probiotics,and other new functional probiotics with immunomodulatory effects. 展开更多
关键词 Probiotics Non-specific immunity Specific immunity Mechanism
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Antibiotics and probiotics differentially shape immunotherapy outcomes in non-small cell lung cancer 认领 引用
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作者 Shuling Ma Zijun Zhai +9 位作者 Rui Ding Shijie Shang Xinyi Liang Shan Yin Haofeng Lin Guomeng Sha Ran Zhang Jinming Yu Qian Song Dawei Chen 《Cancer Biology & Medicine》 SCIE CAS CSCD 2026年第5期703-716,共14页
The introduction of immune checkpoint inhibitors(ICIs)has substantially improved therapeutic outcomes in patients with non-small cell lung cancer(NSCLC)but marked inter-individual variability in treatment response per... The introduction of immune checkpoint inhibitors(ICIs)has substantially improved therapeutic outcomes in patients with non-small cell lung cancer(NSCLC)but marked inter-individual variability in treatment response persists. 展开更多
关键词 non small cell lung cancer probiotics immune checkpoint inhibitors icis immunotherapy antibiotics immune checkpoint inhibitors
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Novel human milk-derived probiotics delays senescence and improves antioxidant capacity in Caenorhabditis elegans by affecting the insulin signaling pathway 认领 引用
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作者 Yu Zhang Bin Liu +9 位作者 Yuying Yuan Xueping Yuan Shujuan Di Junying Zhao Weicang Qiao Xianping Li Lu Liu Zonghan Zhou Juncai Hou Lijun Chen 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第6期2809-2820,共12页
Probiotics have received considerable attention owing to their potential benefits in maintaining intestinal health,modulating immune function,and antioxidant activity.The antioxidant capacity of recently isolated and ... Probiotics have received considerable attention owing to their potential benefits in maintaining intestinal health,modulating immune function,and antioxidant activity.The antioxidant capacity of recently isolated and screened probiotics have not been characterized.Therefore,the present study used Caenorhabditis elegans as a model to investigate the effects of three novel probiotics(Limosiactobacillus reuteri B1-10,Lactobacillus paragasseri B1-26,and Lacticaseibacillus rhamnosus B2-1)and their probiotic complexes,isolated from breast milk,on the ability to delay aging and antioxidant capacity.Probiotics significantly prolonged the lifespan of nematodes by reducing lipofuscin accumulation,and their average lifespan was prolonged by19.40%(B1-10),7.72%(B1-26),19.72%(B2-1)and 20.30%(complex probiotic),respectively.The probiotics reduce nematode fecundity and retard their growth and development,possibly due to dietary restriction.Additionally,the probiotics reduced the accumulation of reactive oxygen species and malondialdehyde content,the reductions were 9.7%-44.5%and 18.69%-46.99%,respectively,and increased the activity of antioxidant enzymes,such as superoxide dismutase,catalase,and glutathione,the increases were 26.22%to 41.72%,30.33%to 83.20%and 77.13%to 171.85%,respectively.The complex probiotic was the most effective in improving the C.elegans resistance to hydrogen peroxide stressors.Furthermore,the probiotics acts on the insulin/insulin-like pathway to regulate the expression of daf-16,which in turn upregulates the expression of sod-3,ctl-1,sod-1,down-regulated the expression of age-1,and promoted the nuclear localization of DAF-16::GFP nematodes to prolong the lifespan and antioxidant capacity of C.elegans.These results provide a new basis and research direction for further analyses of the role of probiotics in maintaining the health,improving stress resistance,and prolonging the lifespan of the host.They also provide potential insights into the development of functional food to facilitate anti-aging management in humans. 展开更多
关键词 Human milk-derived probiotics Caenorhabditis elegans Delayed ageing Antioxidant activity
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Exploring the bidirectional skin-brain axis:Mental health,dermatologyrelated quality of life,and the role of probiotics 认领 引用
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作者 Polyanna de Mello Débora Fernandes Pinheiro +3 位作者 Emilaine Ferreira dos Santos Daniele Gonçalves Vieira Karolyne Kruger Carvalho Eing Vania Schmitt 《Journal of Dermatologic Science and Cosmetic Technology》 2026年第1期92-98,共7页
The skin-brain axis plays a key role in connecting dermatological health,mental health,and the gut microbiota.This study investigated the associations between anxiety,depression,stress,dermatology-related quality of l... The skin-brain axis plays a key role in connecting dermatological health,mental health,and the gut microbiota.This study investigated the associations between anxiety,depression,stress,dermatology-related quality of life(DLQI),and probiotic intake in 305 Brazilian adults.Women presented higher scores for anxiety(13.0±10.5 vs.7.7±8.1,p0.05),likely due to low intake levels.Multiple linear regression showed that stress and depression were independent predictors of anxiety,with a final model of R2=0.66 and p<0.01.The findings highlight the bidirectional nature of the skin-brain axis and the greater burden of psychological and dermatological symptoms in women.Further studies that incorporate culturally relevant dietary patterns and longitudinal designs are needed to clarify these interactions. 展开更多
关键词 Gut Microbiota Microbiome Skin health Brain-gut interaction Stress Mood disorders Skin-brain axis Probiotics
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Constipation targeted monostrain and multispecies probiotics:effects on symptoms and gut microbiota 认领 引用
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作者 Yanqing Zeng Penglin He +8 位作者 Chenang Lyu Yuwei Wu Xinyu Zhao Qihui Gu Shi Wu Youxiong Zhang Xianhu Wei Ran An Qingping Wu 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第7期3256-3268,共13页
Probiotics,classified into monostrain,multistrain and multispecies formulations,have been suggested as effective interventions for alleviating constipation related symptoms by modulating gut motility and microbiota co... Probiotics,classified into monostrain,multistrain and multispecies formulations,have been suggested as effective interventions for alleviating constipation related symptoms by modulating gut motility and microbiota composition.However,the comparative efficacy of these probiotics has not been systematically evaluated.This study presents a systematic review and meta-analysis of randomized controlled trials(RCTs)to assess the effects of monostrain and multispecies probiotics on constipation symptoms and gut microbiota.A total of 15 eligible RCTs were included in the analysis.Probiotic supplementation significantly improved spontaneous bowel movements(standardized mean difference(SMD)=0.60,95%confidence interval(CI)(0.27,0.94),P=0.0005)and stool consistency(SMD=0.25,95%CI(0.03,0.48),P=0.03),but had no significant effect on gut transit time(SMD=-0.04,95%CI(-0.34,0.27),P=0.82)or quality of life(QoL)scores(P=0.42).Importantly,no superior efficacy of multispecies probiotics over monostrain formulations was observed,except for a modest improvement in QoL(P<0.00001).Additionally,probiotics had a measurable impact on gut microbiota composition,although changes in microbial diversity were not consistently correlated with clinical outcomes.Collectively,these findings suggest that probiotics can be effective in alleviating specific constipation-related symptoms,but the choice between monostrain and multispecies formulations should be based on strain-specific characteristics rather than the number of strains or species included.Additionally,this study underscored the need for future research into optimizing strain combinations and understanding probiotic-host interactions to enhance therapeutic outcomes. 展开更多
关键词 Probiotics Systematic Constipation Intestinal microbiota Meta-analysis
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Effect of probiotics on Alzheimer’s disease:a system review and meta-analysis of randomized controlled trials 认领 引用
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作者 LÜMeng-ze WANG Ru-yu +9 位作者 ZHOU Zi-jing HAO Zong-yun CHEN Si-qi LIN Hong-ji GUO Yang-yang ZHAO Zi-hao BA Ya-nan YANG Yi-meng YANG Heng-yao MA Jun 《解剖学报》 CAS CSCD 2026年第4期410-417,共8页
Objective To explore possible healing advantages of probiotics in controlling Alzheimer’s diseese(AD).Methods Conducting an extensive evaluation of probiotics’healing effects,encompassing various facets and perspect... Objective To explore possible healing advantages of probiotics in controlling Alzheimer’s diseese(AD).Methods Conducting an extensive evaluation of probiotics’healing effects,encompassing various facets and perspectives.We conducted an extensive search across 9 databases with no language restrictions,spanning from the inception of research to March 7,2025,to identify randomized controlled studies examining the impact of probiotic therapy on.A meta-analysis was then performed using random-effects models to determine the standardized mean difference(SMD),I2 statistic,and 95%confidence interval(CI).Results The study eventually incorporated eight randomized controlled trials(RCT),with 261 individuals in probiotic cohort and 256 in the placebo group.Probiotics significantly improved cognitive function,promoted total anti-oxidant capacity and mitigated the pro-oxidant process and inflammation.Conclusion The significance of probiotic supplements lies in their ability to enhance cognitive abilities in individuals with cognitive deficits,offering both theoretical underpinnings and actionable advice for using probiotics clinically in AD treatment. 展开更多
关键词 Alzheimer’s disease Cognition Meta-analysis Oxidative stress Probiotic
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Letter to the Editor:Deciphering macrophage heterogeneity and optimizing probiotics via spatial multi-omics 认领 引用
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作者 Di Meng Bin-Bin Zhang Jia-Nan Zhao 《World Journal of Gastrointestinal Pharmacology and Therapeutics》 2026年第2期175-178,共4页
We read the paper published in World Journal of Gastroenterology by Yang et al on how Bifidobacterium species alleviate colitis by modulating deoxycholic acid(DCA)levels and macrophage polarization,which provides impo... We read the paper published in World Journal of Gastroenterology by Yang et al on how Bifidobacterium species alleviate colitis by modulating deoxycholic acid(DCA)levels and macrophage polarization,which provides important insights into the microbiome-immune axis.However,the classic M1/M2 polarization model oversimplifies the plasticity of macrophages and fails to account for the spatial heterogeneity of the intestinal microenvironment.Therefore,we propose integrating spatial transcriptomics and spatial metabolomics to resolve the intricate correlations between DCA distribution and specific macrophage subsets.Building upon this,we further discuss the transition from broad-spectrum probiotic supplementation to mechanism-driven precision probiotic strategies,emphasizing the future need to develop engineered strains capable of spatial awareness and metabolic pathway remodeling.This spatial multiomics-guided precision intervention framework holds promise for advancing colitis treatment toward approaches with greater mechanistic depth. 展开更多
关键词 Macrophage plasticity Spatial transcriptomics Spatial metabolomics Deoxycholic acid Precision probiotics Colitis
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Beneficial effects of probiotics on Litopenaeus vannamei growth and immune function via the recruitment of gut Rhodobacteraceae symbionts 认领 引用 被引量：2
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作者 Hao-Nan Sha Yang-Ming Lu +3 位作者 Ping-Ping Zhan Jiong Chen Qiong-Fen Qiu Jin-Bo Xiong 《Zoological Research》 SCIE CAS CSCD 2025年第2期388-400,共13页
Probiotic supplementation enhances the abundance of gutassociated Rhodobacteraceae species,critical symbionts contributing to the health and physiological fitness of Litopenaeus vannamei.Understanding the role of Rhod... Probiotic supplementation enhances the abundance of gutassociated Rhodobacteraceae species,critical symbionts contributing to the health and physiological fitness of Litopenaeus vannamei.Understanding the role of Rhodobacteraceae in shaping the shrimp gut microbiota is essential for optimizing probiotic application.This study investigated whether probiotics benefit shrimp health and fitness via the recruitment of Rhodobacteraceae commensals in the gut.Probiotic supplementation significantly enhanced feed conversion efficiency,digestive enzyme activity,and immune responses,thereby promoting shrimp growth.Additionally,probiotics induced pronounced shifts in gut microbial composition,enriched gut Rhodobacteraceae abundance,and reduced community variability,leading to a more stable gut microbiome.Network analysis revealed that the removal of Rhodobacteraceae nodes disrupted gut microbial connectivity more rapidly than the removal of nonRhodobacteraceae nodes,indicating a disproportionate role of Rhodobacteraceae in maintaining network stability.Probiotic supplementation facilitated the migration of Rhodobacteraceae taxa from the aquatic environment to the shrimp gut while reinforcing deterministic selection in gut microbiota assembly.Transcriptomic analysis revealed that up-regulation of amino acid metabolism and NF-κB signaling pathways was positively correlated with Rhodobacteraceae abundance.These findings demonstrate that probiotic supplementation enriches key Rhodobacteraceae taxa,stabilizes gut microbial networks,and enhances host digestive and immune functions,ultimately improving shrimp growth performance.This study provides novel perspectives on the ecological and molecular mechanisms underlying the beneficial effects of probiotics on shrimp fitness. 展开更多
关键词 Probiotic supplementation Litopenaeus vannamei Gut microbiome Rhodobacteraceae Transcriptomic response
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Probiotic potential of lactic acid bacteria isolated from yaks 认领 引用 被引量：2
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作者 Yuanyuan He Feiran Li +7 位作者 Mengen Xu Chao Jin Yu Zhang Shah Nawaz Muhammad Fakhar-e-Alam Kulyar Mudassar Iqbal Zhen Qin Jiakui Li 《Animal Diseases》 CAS CSCD 2025年第1期73-84,共12页
The prevalence of bacterial digestive diseases in plateau animals has caused considerable losses to the Tibetan live‑stock industry.Therefore,this study aimed to isolate safe lactic acid bacteria(LAB)with beneficial p... The prevalence of bacterial digestive diseases in plateau animals has caused considerable losses to the Tibetan live‑stock industry.Therefore,this study aimed to isolate safe lactic acid bacteria(LAB)with beneficial probiotic proper‑ties to protect yaks from intestinal diseases.After 16S rDNA matching,four strains of Lactobacillus fermentum(A4),Pediococcus pentosaceus(A3.4 and A1.2),and Pediococcus acidilactici(B1.9)were isolated from the intestinal tissues and content of healthy yaks.The results indicated that A4 was more tolerant to bile salt(0.3%),while A3.4 had better stability in an acidic(pH=3.0)environment.The results of the antibacterial activity test suggested that the isolates inhibited most pathogenic bacteria by up to 20%,except for A3.4,which inhibited Pasteurella and Staphylococcus aureus by more than 20%.Moreover,the results of the antioxidant test demonstrated that A4 and A3.4 had potent antioxidant activity.In addition,the drug sensitivity test revealed that the isolates were susceptible to commonly used antibiotics.In terms of safety,the isolates promoted growth,enhanced intestinal development,and protected the intestinal barrier without causing any adverse effects.In conclusion,LAB isolated from yak intestinal contents are potential probiotics with excellent antibacterial properties. 展开更多
关键词 Lactobacillus Probiotics Identification Yaks Tibet
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Cross-Talk between Next-Generation Probiotics and the Immune System 认领 引用 被引量：2
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作者 Mikhail Syromyatnikov Mariya Gladkikh +3 位作者 Ekaterina Nesterova Shima Kazemzadeh Polina Morozova Olga Korneeva 《BIOCELL》 SCIE 2025年第9期1573-1603,共31页
The gut microbiome is a complex community of microorganisms that plays a direct role in the health of both the gastrointestinal tract and the entire body.Numerous factors influence the abundance and diversity of gut m... The gut microbiome is a complex community of microorganisms that plays a direct role in the health of both the gastrointestinal tract and the entire body.Numerous factors influence the abundance and diversity of gut microbiota.Microbial imbalance can contribute to disease development.Probiotics are biologically active supplements with promising properties that have high therapeutic potential.Currently,there is a tendency to switch from classic probiotic microorganisms represented by lactic acid bacteria to next-generation probiotics due to their unique ability to influence the human immune system.New-generation probiotics include bacteria such as Akkermansia muciniphila,Faecalibacterium prausnitzii,Bacteroides sp.,Prevotella sp.,Roseburia sp.,and Eubacterium sp.Nextgeneration probiotics can affect host immune cells by secreting various substances,such as butyrate in F.prausnitzii,or through interaction with Toll-like receptors of intestinal epithelial cells,such as A.muciniphila.Studying the role of next-generation probiotics in immune regulation is a promising area of research.This study describes the interactions of next-generation probiotics with the immune system.Understanding the mechanisms of such interactions will improve the treatment of various diseases. 展开更多
关键词 New generation probiotics immune system gut Akkermansia muciniphila Faecalibacterium prausnitzii Bacteroides sp. Prevotella sp. Roseburia sp. Eubacterium sp
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