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Insights into Student Perceptions of Error Feedback and Improvement Preferences in Online Programming Education 认领 引用
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作者 Li Zhang Tianze Wang +1 位作者 Jing Jiang Yufei Zhou 《计算机教育》 2026年第3期176-189,共14页
Online programming platforms are popular in programming education.However,there has been no research investigating students’real opinions and expectations of the error feedback mechanisms,leaving educators without a ... Online programming platforms are popular in programming education.However,there has been no research investigating students’real opinions and expectations of the error feedback mechanisms,leaving educators without a solid data foundation when attempting to improve the error feedback mechanisms.This paper makes a survey of 834 students across various programming courses and investigates student perceptions of error feedback mechanisms on online programming platforms.It explores the effectiveness of existing feedback,student satisfaction,and preferences for potential improvements,focusing on automatic error localization and program repair mechanisms.Results reveal a significant portion of students are dissatisfied with current feedback due to its limited informativeness.Students also express a clear demand for stronger feedback mechanisms,such as error localization and repair hints.Nevertheless,they prefer feedback that subtly guides them toward solutions,rather than providing direct and explicit answers,valuing the opportunity to enhance their debugging skills.The findings suggest a need for balanced,educational-focused feedback mechanisms that aid learning while promoting independent problem-solving. 展开更多
关键词 Error feedback Online programming education Program error localization Automated program repair
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Quality-guaranteed Dubins Path Planning for USV Based on Mixed-integer Piecewise linear Programming for Addressing the Extended Minimum-time Intercept Problem 认领 引用 被引量：1
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作者 Xing Zhou Kelin Zhu +3 位作者 Shuang Liu Zhaoqing Li Wenxin Zhang Kang Du 《哈尔滨工程大学学报（英文版）》 CSCD 2026年第1期216-227,共12页
During the use of robotics in applications such as antiterrorism or combat,a motion-constrained pursuer vehicle,such as a Dubins unmanned surface vehicle(USV),must get close enough(within a prescribed zero or positive... During the use of robotics in applications such as antiterrorism or combat,a motion-constrained pursuer vehicle,such as a Dubins unmanned surface vehicle(USV),must get close enough(within a prescribed zero or positive distance)to a moving target as quickly as possible,resulting in the extended minimum-time intercept problem(EMTIP).Existing research has primarily focused on the zero-distance intercept problem,MTIP,establishing the necessary or sufficient conditions for MTIP optimality,and utilizing analytic algorithms,such as root-finding algorithms,to calculate the optimal solutions.However,these approaches depend heavily on the properties of the analytic algorithm,making them inapplicable when problem settings change,such as in the case of a positive effective range or complicated target motions outside uniform rectilinear motion.In this study,an approach employing a high-accuracy and quality-guaranteed mixed-integer piecewise-linear program(QG-PWL)is proposed for the EMTIP.This program can accommodate different effective interception ranges and complicated target motions(variable velocity or complicated trajectories).The high accuracy and quality guarantees of QG-PWL originate from elegant strategies such as piecewise linearization and other developed operation strategies.The approximate error in the intercept path length is proved to be bounded to h2/(4√2),where h is the piecewise length. 展开更多
关键词 Minimum-time intercept problem Dubins vehicle Mixed-integer piecewise-linear program Linearization Approximate error trigonometric function USV
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Pharmacological mechanisms of natural products with antidepressant effects:A focus on the programmed cell death regulation 认领 引用
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作者 Guangheng Zhang Shimeng Lv +9 位作者 Shengchuan Bao Weijie Zhao Yunhao Yi Haonan Gao Xia Zhong Xiangyu Li Fengzhao Liu Yitong Lu Siyuan Sun Jing Teng 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2026年第1期120-141,共22页
Depression is a prevalent mental disorder characterized by persistent disinterest and a depressed mood,with severe cases potentially leading to suicide.In recent years,the incidence of depression has steadily increase... Depression is a prevalent mental disorder characterized by persistent disinterest and a depressed mood,with severe cases potentially leading to suicide.In recent years,the incidence of depression has steadily increased,making it the second-largest global health burden.The pathogenesis of depression involves a series of complex pathological mechanisms,although the key underlying causes remain unclear.Programmed cell death(PCD),including apoptosis,autophagy,pyroptosis,ferroptosis,and necroptosis,involves highly organized gene expression processes that may influence the occurrence and development of depression by regulating cellular fate.Furthermore,numerous studies have shown that natural products can modulate PCDs through various signaling pathways,presenting significant potential for managing depression.Natural products offer benefits such as cost-effectiveness,fewer side effects,and other advantages,making them viable supplements or alternatives to traditional antidepressant drugs.To explore this potential,we reviewed studies demonstrating the antidepressant effects of natural products through multi-target modulation of PCDs.In addition,we discussed the toxicity and clinical applications of these natural products.This study highlights that diverse core biological pathways and targets are involved in determining the fate of depression-associated brain cells,including the PI3K/Akt signaling pathway,caspase-8,GSDMD,and others.In conclusion,the multi-target mechanisms of PCD regulation by natural products may provide a promising foundation for the future development of novel antidepressant medications. 展开更多
关键词 Depression Pharmacological mechanism Programmed cell death Natural products Antidepressant
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Multi-phase trajectory programming with divert capability for lunar lander powered descent 认领 引用
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作者 ZHANG Xiaowen WANG Dayi +2 位作者 HUANG Xiangyu LI Ji WANG Tianshu 《中国空间科学技术（中英文）》 CSCD 北大核心 2026年第3期143-156,共14页
It is important for a lunar lander to possess a large divert capability during the final landing phase,as this can enhance the tolerance for flight deviations in the early phase or improve the obstacle avoidance perfo... It is important for a lunar lander to possess a large divert capability during the final landing phase,as this can enhance the tolerance for flight deviations in the early phase or improve the obstacle avoidance performance.Therefore,when designing the powered descent trajectory,sufficient final phase divert capability should be reserved at the minimum propellant cost.To this end,a multi-phase trajectory programming(MPTP)method for powered descent with approaching phase divert capability is proposed.First,the entire powered descent trajectory is divided into the main braking phase and the approaching phase.The main braking phase is responsible for dissipating the majority of the initial velocity.The approaching phase is responsible for safely and precisely flying toward the landing site.It is nominally a vertical descent trajectory and possesses equal divert capability in all horizontal directions.Then,a constant-thrust linear tangent guidance(LTG)accounting for the lunar curvature is designed for the main braking phase.For the approaching phase,a variable-thrust lossless convex programming(LCP)guidance considering the constraints of tilt angle and glide-slope angle is developed.Subsequently,to connect the two phases and further optimize the propellant consumption throughout the entire trajectory,a method for determining the phase switching condition is proposed.The originally difficult-to-solve two-parameter optimization problem is decomposed into two more easily solvable subproblems,which are solved iteratively via a bilevel optimization framework.Finally,the divert capability of the proposed method is verified through numerical simulation.The programmed trajectory is basically consistent with the results of the pseudospectral method,with the difference in propellant consumption being only 0.006%.This method is suitable for the rapid iterative design of nominal trajectories for lunar lander powered descent in engineering applications. 展开更多
关键词 lunar landing powered descent trajectory programming multi-phase divert capability
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FTCSEM—A FORTRAN-based parallelized 1D CSEM forward and inversion program for arbitrary source-receiver geometry 认领 引用
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作者 Wei-ying Chen Si-xu Han +2 位作者 Wan-ting Song Yu-lian Zhu Zheng Liu 《Applied Geophysics》 SCIE CSCD 2026年第2期693-709,870,共17页
This study introduces FTCSEM,a FORTRAN-based,parallelized one-dimensional controlledsource electromagnetic(CSEM)forward modeling and inversion software capable of accommodating arbitrary source-receiver confi guration... This study introduces FTCSEM,a FORTRAN-based,parallelized one-dimensional controlledsource electromagnetic(CSEM)forward modeling and inversion software capable of accommodating arbitrary source-receiver confi gurations.In comparison to existing one-dimensional CSEM tools,FTCSEM incorporates several signifi cant enhancements:it supports transmitters of diverse shapes,quantities,and spatial locations;permits receivers to be positioned flexibly on the surface,subsurface,or in the atmosphere;facilitates simulations and inversions in both frequency and time domains;integrates an adaptive regularized inversion algorithm with multiple model constraints;and leverages GPU-accelerated parallel computing to attain high computational efficiency.Validation through numerical experiments and field data inversion confirms the program’s accuracy and practical applicability.The findings indicate that FTCSEM performs robustly in complex geoelectric environments,multi-source and multi-receiver arrangements,as well as multi-component joint inversion scenarios,thereby offering a versatile and powerful tool for advancing CSEM research and applications. 展开更多
关键词 CSEM forward modeling regularized inversion parallel computing program
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Open-loop control of combustion instabilities in a full-scale annular ramjet combustor using linear genetic programming 认领 引用
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作者 Jianguo TAN Zheng XU +2 位作者 Yao LIU Dongdong ZHANG Yi HOU 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2026年第2期20-28,共9页
The operational demands of a wide range significantly exacerbate combustion instability issues within ramjet combustor.To suppress combustion oscillations,an open-loop control system utilizing Linear Genetic Programmi... The operational demands of a wide range significantly exacerbate combustion instability issues within ramjet combustor.To suppress combustion oscillations,an open-loop control system utilizing Linear Genetic Programming(LGP)has been developed for a full-scale annular ramjet combustor.The LGP is used to generate control laws that include multi-frequency forcing.These laws are then transformed into square waves to actuate the solenoid valve,which modulates the kerosene supply for open-loop control.The results show that the duty cycle has little effect on instability amplitude,whereas an increase in frequency leads to a remarked reduction in combustion amplitude.After five generations evolvements,the pressure amplitude is reduced by 40.6% under the optimal control law generated by LGP.Furthermore,the machine learning process is depicted using a proximity map of control law similarity,with the search pathway visualized by the steepest descent.All individuals go forward to the upper left corner of the map with the evolution process,terminating at the optimal individual of the fifth generation. 展开更多
关键词 Annular ramjet combustor Combustion instabilities Linear genetic programming Machine learning Open-loop control
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Reprogramming induced neurons from olfactory ensheathing glial cells: A feasible approach for spinal cord injury repair 认领 引用
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作者 Javier Sierra María Portela-Lomba +1 位作者 Diana Simón M.Teresa Moreno-Flores 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第1期296-297,共2页
Every year, around the world, between 250,000 and 500,000 people suffer a spinal cord injury(SCI). SCI is a devastating medical condition that arises from trauma or disease-induced damage to the spinal cord, disruptin... Every year, around the world, between 250,000 and 500,000 people suffer a spinal cord injury(SCI). SCI is a devastating medical condition that arises from trauma or disease-induced damage to the spinal cord, disrupting the neural connections that allow communication between the brain and the rest of the body, which results in varying degrees of motor and sensory impairment. Disconnection in the spinal tracts is an irreversible condition owing to the poor capacity for spontaneous axonal regeneration in the affected neurons. 展开更多
关键词 injury feasible programming
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CD44-targeting and ZIF-8 gated gold nanocage for programmed breast cancer therapy through Pt-induced immunogenic cell death 认领 引用
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作者 Xin Li Fei Xiong +7 位作者 Xudong Cao Wei Liu Haobo Chen Jiayu He Weina Zhang Longguang Tang Wei Huang Xikuang Yao 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第1期462-467,共6页
The field of nanomedicine has been revolutionized by the concept of immunogenic cell death(ICD)-enhanced cancer therapy,which holds immense promise for the efficient treatment of cancer.However,precise delivery of ICD... The field of nanomedicine has been revolutionized by the concept of immunogenic cell death(ICD)-enhanced cancer therapy,which holds immense promise for the efficient treatment of cancer.However,precise delivery of ICD inducer is severely hindered by complex biological barriers.How to design and build intelligent nanoplatform for adaptive and dynamic cancer therapy remains a big challenge.Herein,this article presents the design and preparation of CD44-targeting and ZIF-8 gated gold nanocage(Au@ZH) for programmed delivery of the 1,2-diaminocyclohexane-Pt(Ⅱ)(DACHPt) as ICD inducer.After actively targeting the CD44 on the surface of 4T1 tumor cell,this Pt-Au@ZH can be effectively endocytosed by the 4T1 cell and release the DACHPt in tumor acidic environment,resulting in ICD effect and superior antitumor efficacy both in vitro and in vivo in the presence of mild 808 nm laser irradiation.By integration of internal and external stimuli intelligently,this programmed nanoplatform is poised to become a cornerstone in the pursuit of effective and targeted cancer therapy in the foreseeable future. 展开更多
关键词 Programmed drug release ZIF-8-gated Gold nanocage Immunogenic cell death Cancer therapy
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Entry trajectory optimization for cross-domain morphing vehicles by hybrid sequential second-order cone programming 认领 引用
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作者 Zheng Li Zhenyue Jia +2 位作者 Zheng Fang Hongmiao Zhou Jianqiao Yu 《Defence Technology（防务技术）》 SCIE EI CAS CSCD 2026年第4期149-175,共27页
This paper proposes a hybrid sequential second-order cone programming(HSSOCP)method with a three-layer scheme for the entry trajectory optimization of the cross-domain morphing vehicles(CDMVs).By defining the new morp... This paper proposes a hybrid sequential second-order cone programming(HSSOCP)method with a three-layer scheme for the entry trajectory optimization of the cross-domain morphing vehicles(CDMVs).By defining the new morphing rate control variable and using relaxation techniques to relax the bank angle constraint,the SOCP-based entry problem is constructed.A dynamic relaxation penal-ization technique is developed in the first layer to overcome artificial infeasibility and significantly enhance initialization robustness.A novel standard oscillation identification(SOI)method is proposed to precisely identify the iteration oscillations of basic SSOCP in the second layer,which can significantly improve the solution accuracy.A soft-trust-region strategy is applied in the third layer to eliminate oscillations and accelerate convergence.Simulation results of two scenarios demonstrate that the proposed SOI method effectively avoids non-standard oscillation interference versus traditional methods.The morphing aircraft can complete tasks better with a 7.01%and 10.43%reduction in heat load respectively compared to fixed-wing aircraft.The HSSOCP method can maintain accuracy while reducing computation time by 63.47%and 73.86%versus VATSSOCP.Monte Carlo simulations further validate the robustness. 展开更多
关键词 Cross-domain vehicle Morphing vehicle Entry trajectory optimization Sequential second-order cone programming Iteration oscillation Hybrid scheme
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H∞Optimal Output Regulation of Unknown Linear Systems via an Adaptive Dynamic Programming and Internal Model 认领 引用
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作者 Yong-Sheng Ma Jian Sun Yong Xu 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2026年第6期1314-1324,共11页
This paper delves into the H∞optimal output regulation problem for continuous-time linear systems with an unknown system model.By integrating the internal model principle with optimal control,we derive an optimal con... This paper delves into the H∞optimal output regulation problem for continuous-time linear systems with an unknown system model.By integrating the internal model principle with optimal control,we derive an optimal control policy and a worst-case disturbance policy through the formulation and solution of a zero-sum game problem.Subsequently,leveraging adaptive dynamic programming,we propose a policy iteration learning algorithm capable of learning both the optimal control policy and the worst-case disturbance policy directly from system data.The existing algorithms necessitate an initial stabilizing policy,a full-rank condition,and the storage of historical data to guarantee algorithm convergence.In contrast,we design a dual policy iteration algorithm equipped with an online learning mechanism,thereby eliminating these additional prerequisites.Simulation results with an antonomous ground vehicle underscore the effectiveness of our proposed algorithm,and its superiority is further demonstrated through comparisons with existing methodologies. 展开更多
关键词 Adaptive dynamic programming internal model principle optimal control output regulation
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Thermal performance optimization in CuO-water nanofluid enclosure with sinusoidal heating using deep learning and multi-expression programming 认领 引用
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作者 Naeem Ullah Aneela Bibi +1 位作者 Yufeng Nie Dianchen Lu 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2026年第5期24-48,共25页
Natural convection in enclosures containing nanofluids has attracted significant attention due to its relevance in thermal management systems.In this context,this study presents a comprehensive numerical investigation... Natural convection in enclosures containing nanofluids has attracted significant attention due to its relevance in thermal management systems.In this context,this study presents a comprehensive numerical investigation of flow and heat transfer in a square cavity saturated with water-based CuO nanofluid having a centrally placed sinusoidal-shaped heated element.All the enclosure walls satisfy the no-slip velocity condition.Thermally,the vertical walls are kept at a cold reference temperature,the lower wall is partially heated at its center,and the remaining portions of the lower and entire upper walls are adiabatic.The internal sinusoidal element is also uniformly heated.The flow dynamics and thermal fields are governed by the two-dimensional steady-state Navier-Stokes and energy equations,solved using the Galerkin finite element method.Additionally,a novel hybrid approach integrating multi-expression programming(MEP)technique with a convolutional neural network bidirectional gated recurrent unit(CNN-BiGRU)deep learning network is also applied to enhance flow and thermal prediction accuracy.This hybrid approach enables precise evaluation of how heater waviness,magnetic field orientation,and nanoparticle dispersion influence flow structure and heat transfer.Results reveal stronger convection at high Rayleigh numbers,magnetic damping at increased Hartmann numbers,and higher temperatures with reduced velocity at greater nanoparticle concentrations.Among the analyzed situations,increasing heater waviness improves heat-transfer performance.Both the MEP and CNN-BiGRU models accurately capture the key features of flow and heat transport trends,indicating that the hybrid approach provides enhanced predictive capability for complex convection-driven nanofluid systems. 展开更多
关键词 Magnetohydrodynamic convection Nanofluid flow simulation Sinusoidal heated source Deep learning Multi-expression programming
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Entry trajectory optimization for cross-domain morphing vehicles using oscillation-avoidance-based multistage trust-region sequential convex programming 认领 引用
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作者 Zheng LI Zheng FANG +1 位作者 Zhenyue JIA Jianqiao YU 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2026年第4期310-333,共24页
This paper develops an Oscillation-avoidance-based Multistage Trust-region Sequential Convex Programming(OMTSCP)method for the highly nonlinear entry trajectory optimization problem of Cross-Domain Morphing Vehicles(C... This paper develops an Oscillation-avoidance-based Multistage Trust-region Sequential Convex Programming(OMTSCP)method for the highly nonlinear entry trajectory optimization problem of Cross-Domain Morphing Vehicles(CDMVs).The decoupling of states and controls for complex nonlinear dynamics is achieved by defining new control and state variables.A series of sub convex problems is formulated by successive linearization and discretization of the constraints.The proposed Trust-region Sequential Convex Programming(TSCP)scheme consists of three stages:an initial guess generation stage,a basic solution stage,and an optimal solution stage.An approach to penalize the dynamic relaxation is firstly developed to obtain an initial guess with considerable accuracy and significantly improve the robustness of the algorithm by overcoming the drawbacks of potential artificial infeasibility.The oscillation phenomenon of the TSCP method under rectangular trust region is then investigated,and a novel N-shape-based oscillation identification method is proposed to identify the oscillation accurately.Finally,an oscillation-avoidance method based on the sort trust-region is proposed to improve the convergence of the TSCP algorithm.Numerical comparisons of the proposed method and a typical TSCP method,as well as the morphing and fixed-morphing vehicles are provided to demonstrate the effectiveness and efficiency of the proposed method and the performance advantages of the morphing vehicle.The robustness of the method is further verified by Monte Carlo simulation. 展开更多
关键词 Convex optimization Cross-domain vehicle Entry trajectory optimization Morphing vehicle Multistage Oscillation phenomenon Trust-region sequential convex programming
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Icariin inhibits tumor-associated neutrophil recruitment via the CXCL8-CXCR2 axis and restrains pro-metastatic programs in colorectal cancer 认领 引用
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作者 Yan-Hua Zhao Juan Chen +2 位作者 Tao Gong Hai-Yan Ge Min Li 《World Journal of Gastroenterology》 SCIE CAS 2026年第11期70-89,共20页
BACKGROUND Icariin(ICA)is a natural compound derived from Epimedium that has shown promise in treating colorectal cancer(CRC)by reducing inflammation,inducing apoptosis,and limiting tumor progression.AIM To elucidate ... BACKGROUND Icariin(ICA)is a natural compound derived from Epimedium that has shown promise in treating colorectal cancer(CRC)by reducing inflammation,inducing apoptosis,and limiting tumor progression.AIM To elucidate the specific mechanisms underlying its therapeutic effects on this malignancy.METHODS We examined the impact of different ICA concentrations on the biological behavior of CRC cells in vitro.We also assessed the protein expression of SMAD4,CX-C motif chemokine ligand 1(CXCL1),and CXCL8,as well as epithelial-mesenchymal transition(EMT)-related signaling molecules,and the mRNA expression of proinflammatory factors.To further explore ICA’s mechanisms in CRC treatment,we introduced small interfering SMAD4 and its negative control group.In CRC cells,we evaluated proliferation,apoptosis,invasion,migration,EMT,and the recruitment of tumor-associated neutrophils(TANs).Moreover,we investigated the role of the CXCL8-C-X-C motif chemokine receptor 2(CXCR2)axis in the recruitment of ICA-affected TANs.In vivo,we preliminarily assessed the therapeutic efficacy of ICA against CRC.In ICA-treated mice,we measured tumor size,histological morphology,apoptosis,and neutrophil infiltration.Additionally,we analyzed the expression of SMAD4,CXCL1,CXCL8,CXCR2,EMT,and proteins related to migration.RESULTS Our findings indicate that ICA attenuated CRC cell proliferation,invasion,and migration,while suppressing TAN recruitment and promoting apoptosis in a concentration-dependent manner.When small interfering SMAD4 was introduced,the anticancer effects of ICA were diminished.Furthermore,disruption of the CXCL8-CXCR2 axis reduced neutrophil recruitment.We found that ICA inhibited tumor growth,improved tumor histology and morphology,alleviated CD66b+neutrophil infiltration,and inhibited EMT in mice with subcutaneous CRC tumors.In addition,ICA appeared to enhance SMAD4 protein expression while suppressing CXCL8 and CXCR2 expression in both in vivo and in vitro experiments.CONCLUSION ICA impedes the recruitment of TANs primarily through SMAD4-mediated modulation of the CXCL8-CXCR2 axis,thereby suppressing EMT and other pro-metastatic programs in CRC. 展开更多
关键词 Icariin Neutrophils Recruitment C-X-C motif chemokine ligand 8-C-X-C motif chemokine receptor 2 axis Colorectal cancer Pro-metastatic program Progression
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Clinical characteristics of programmed death-1 inhibitors for older patients with advanced pancreatic cancer 认领 引用
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作者 Yun-Yun Lu Yi Lu Pan Chen 《World Journal of Gastrointestinal Oncology》 SCIE 2026年第2期192-206,共15页
BACKGROUND Pancreatic cancer(PC),a highly malignant gastrointestinal cancer,is generally diagnosed at an advanced stage.However,traditional therapies for advanced PC are limited and often unsuitable for older patients... BACKGROUND Pancreatic cancer(PC),a highly malignant gastrointestinal cancer,is generally diagnosed at an advanced stage.However,traditional therapies for advanced PC are limited and often unsuitable for older patients.AIM To identify clinical predictors in older patients with advanced PC to facilitate individualized treatment.METHODS This was a retrospective clinical analysis involving 99 patients aged≥65 years with advanced PC who received programmed death-1(PD-1)inhibitors at Ningbo Medical Center Lihuili Hospital from January 2019 to January 2025.Univariate and multivariate analyses were conducted to identify clinical predictors for survival outcomes,utilizing blood levels and other clinical information.RESULTS The median progression-free survival(PFS)was 4.6 months[95%confidence interval(CI):3.700-5.800],and the median overall survival(OS)was 6.5 months(95%CI:5.700-8.200).Multivariate analysis helped identify meaningful clinical differences in PFS and OS across subgroups,including factors such as Eastern Cooperative Oncology Group performance status,prognostic nutritional index,and triglyceride levels.Univariate analysis showed that factors such as the location of primary PC,carbohydrate antigen 199 levels,systemic immune-inflammation,neutrophil-to-lymphocyte ratio,and the combination therapy comprising PD-1 inhibitors and radiotherapy are of significant clinical relevance to both PFS and OS.CONCLUSION The treatment of advanced PC with PD-1 inhibitors presented several potential independent clinical predictive indicators of survival outcomes in older patients.This study highlighted the importance of pre-treatment clinical characteristics and hematological variables for predicting treatment outcomes in older patients with PC. 展开更多
关键词 Advanced pancreatic cancer Older adults Programmed death-1 inhibitors Eastern Cooperative Oncology Group performance status Prognostic nutritional index Triglyceride
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Effectiveness of a stepped self-care program for stroke survivors:A quasi-experimental study 认领 引用
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作者 Zihao Ruan Dan Wang +5 位作者 Wenna Wang Yongxia Mei Hui Wang Suyan Chen Qiushi Zhang Zhenxiang Zhang 《International Journal of Nursing Sciences》 CSCD 2026年第1期45-52,I0004,共8页
Objectives This study aimed to evaluate the effectiveness of the stepped self-care program on the self-care,self-efficacy,and quality of life of stroke survivors.Methods This quasi-experimental study allocated 110 str... Objectives This study aimed to evaluate the effectiveness of the stepped self-care program on the self-care,self-efficacy,and quality of life of stroke survivors.Methods This quasi-experimental study allocated 110 stroke survivors from two neurology wards into an intervention group(n=55)who received the stepped self-care program and a control group(n=55)who received usual care from June to December 2023.The Self-Care of Stroke Inventory,Stroke Self-Efficacy Questionnaire,and the short version of the Stroke Specific Quality of Life Scale were administered at baseline(T0),immediately post-intervention(T1),and at 1-month(T2)and 3-month(T3)follow-ups.Data were analyzed using repeated measures analyses of variance,and generalized estimating equations.Results A total of 48 participants in the intervention group and 50 participants in the control group completed the study.No statistically significant differences were observed at T0 in any of the measured indicators(all P>0.05).The study showed significant group,time,and group×time interaction effects across the assessed outcomes(all P<0.05).Follow-up between-group comparisons at T1,T2,and T3 indicated that the intervention group had significantly higher scores in self-care maintenance,self-care monitoring,self-care management,self-efficacy,and quality of life than the control group(all P<0.001).Conclusions The stepped self-care program significantly improved self-care behaviors,self-efficacy,and quality of life among stroke survivors.These findings support the broader implementation of this approach in post-discharge home self-care. 展开更多
关键词 Quality of life Self-care Self-efficacy Stepped care program Stroke
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Synergistic Cell Death:Cisplatin Inflames Tumors by Coordinating Multiple Death Programs 认领 引用
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作者 Ju Li Pengcheng Rao +11 位作者 Dan Yang Tong Zhou Jianguo Gan Die Lv Shuting Zhou Yang Peng Xiaoqiang Xia Qianming Chen Yuchen Jiang Jian Jiang Xiaoping Xu Xiaodong Feng 《BIOCELL》 SCIE 2026年第5期176-196,共21页
Objective:Multiple programmed cell death(PCD)pathways have been individually reported to be triggered by cisplatin,but whether and how they are co-regulated remains unclear.In this study,we comprehensively investigate... Objective:Multiple programmed cell death(PCD)pathways have been individually reported to be triggered by cisplatin,but whether and how they are co-regulated remains unclear.In this study,we comprehensively investigate the spectrum of cisplatin-induced PCD.Methods:We employed integrated in vitro and in vivo models including human cancer cell lines,a Cal27 xenograft mouse model,and paired clinical specimens from an oral squamous cell carcinoma patient receiving neoadjuvant cisplatin-based chemotherapy.A comprehensive methodological suite-encompassing cell death assays,Western blotting,Hematoxylin and eosin staining,immunofluorescence,Cyclic multiplexed tissue staining,and pathway-specific pharmacological inhibitors was utilized to dissect the activation of apoptosis,necroptosis,pyroptosis,and ferroptosis.Results:Cisplatin simultaneously upregulates markers of PCD pathways(including apoptosis,necroptosis,pyroptosis,and ferroptosis)in a dose-or time-dependent manner.Pharmacological inhibition or genetic knockdown of key genes in each pathway significantly reduced cytotoxicity.confirming their functional roles.Notably,indicators of key pro-inflammatory death modalities,pyroptosis and ferroptosis,were prominently co-upregulated in both xenograft tumors and clinical patient samples,suggesting that these two forms of PCD may represent the predominant death forms in cisplatin-induced tumor cell death.Conclusion:Cisplatin induces the coordinated activation of multiple cell death programs within a unified framework.Prominent engagement of immunogenic cell death pathways,particularly pyroptosis and ferroptosis,provides a mechanistic basis for the clinically observed synergy between cisplatin and immune checkpoint blockade therapy. 展开更多
关键词 Cisplatin programmed cell death pyroptosis necroptosis ferroptosis apoptosis
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Stimulating peripheral nerves to alleviate disease symptoms program:A new perspective on regulating the cardiac system 认领 引用
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作者 Jiamian Zhang Heng Zhang +2 位作者 Hongyi Cheng Hang Sun Kun Liu 《Journal of Traditional Chinese Medical Sciences》 CAS CSCD 2026年第1期70-76,共7页
To systematically elucidate the central role of the cardiac autonomic nervous system(ANS)in maintaining cardiovascular homeostasis,analyze the pathological mechanisms underlying its dysregulation,integrate multidiscip... To systematically elucidate the central role of the cardiac autonomic nervous system(ANS)in maintaining cardiovascular homeostasis,analyze the pathological mechanisms underlying its dysregulation,integrate multidisciplinary research findings from the U.S.stimulating peripheral nerves to alleviate disease symptoms(SPARC)program,and evaluate the unique advantages and current limitations of acupuncture in modulating cardiac ANS function,ultimately proposing novel strategies for the prevention and treatment of cardiovascular diseases.A systematic literature review was conducted to synthesize current knowledge on the fundamental regulatory mechanisms of the cardiac ANS,the SPARC program's innovative contributions to neuroanatomy and neural pathway mapping,as well as clinical and experimental evidence supporting acupuncture's modulation of the ANS.The SPARC program has made significant progress in elucidating the anatomical organization and neural circuitry of the cardiac ANS through interdisciplinary collaboration,offering novel insights and methodological frameworks for studying cardiac autonomic regulation.Acupuncture,as a cornerstone of traditional medicine,has demonstrated both specificity and multi-target regulatory effects on the cardiac ANS through clinical and experimental studies.However,challenges remain,including an incomplete mechanistic understanding,technical limitations in research methodologies,and difficulties in translating findings into clinical practice.Future research on acupuncture should build upon its inherent strengths while advancing its integration with modern scientific and technological approaches.Strengthening interdisciplinary collaboration and leveraging artificial intelligence can open new frontiers in mechanistic exploration and technological innovation.These efforts will facilitate the internationalization of acupuncture research and contribute innovative perspectives and therapeutic strategies for cardiovascular disease prevention and treatment. 展开更多
关键词 Cardiac autonomic nervous system SPARC program Acupuncture Mechanistic understanding Multidisciplinary collaboration
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Patterns and mechanisms of programmed cell death in bloom-forming Microcystis aeruginosa induced by potent allelochemical juglone 认领 引用
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作者 Xu YANG Jinyuan CHEN +4 位作者 Ang GAO Jinting LI Yulu HU Haiying WANG Xin ZHANG 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2026年第3期1116-1131,共16页
Harmful algal blooms(HABs)caused by Microcystis aeruginosa are a major global threat to the aquatic environment and public health.Allelochemicals derived from aquatic and terrestrial plants are emerging weapons for er... Harmful algal blooms(HABs)caused by Microcystis aeruginosa are a major global threat to the aquatic environment and public health.Allelochemicals derived from aquatic and terrestrial plants are emerging weapons for eradicating these blooms.Here,juglone outperformed the most reported allelochemicals in terms of algicidal activity against M.aeruginosa,with a half-maximal inhibitory concentration(IC50)of 0.078 mg/L.The algal growth suppression resulted from the activation of programmed cell death(PCD)upon juglone treatment.Ultrastructural changes of juglone-induced cyanobacterial cells were characterized by marked cytoplasmic vacuolization,as indicated by transmission electron microscopy(TEM)and scanning electron microscope(SEM).Dose-and timedependent biochemical features of M.aeruginosa in response to juglone included the increase in DNA fragmentation,caspase-3-like and caspase-9-like activities,phosphatidylserine externalization and chromatin condensation.Morphological and biochemical analyses revealed two modes of cell death,including apoptotic-like and autophagic-like PCD.The juglone-induced PCD was associated with increased reactive oxygen species(ROS)and nitric oxide(NO)as potential signal molecules.The blockage of the electron flow beyond(primary quinone acceptor)QA at photosystem II(PSII)acceptor side mediated the generation of ROS in M.aeruginosa exposed to juglone.Cotreatments with sodium tungstate,a nitrate reductase(NR)inhibitor,with the juglone successfully reduced NO production,suggesting that NO production in M.aeruginosa cells was mainly through NR pathway.The current study sheds light on the inhibition and action mode of juglone on M.aeruginosa from the perspective of PCD,as well as its potential for controlling cyanobacterial blooms. 展开更多
关键词 juglone Microcystis aeruginosa programmed cell death(PCD) reactive oxygen species(ROS) nitric oxide(NO)
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Laser-induced in situ reprogramming of magnetic shape memory composites for adaptive devices 认领 引用
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作者 Qianqian Zhang Rui Li +5 位作者 Yuan Tao Yiyu Chen Yanlei Hu Dong Wu Jiaru Chu Jiawen Li 《International Journal of Extreme Manufacturing》 SCIE EI CAS CSCD 2026年第1期767-779,共13页
Programmableeprogrammable magneto-responsive composites(MRCs)are highly desirable for applications in soft robotics,morphable actuators,and biomedical devices due to their capabilities of undergoing reversible,complex... Programmableeprogrammable magneto-responsive composites(MRCs)are highly desirable for applications in soft robotics,morphable actuators,and biomedical devices due to their capabilities of undergoing reversible,complex,untethered,and rapid deformations.However,current MRC-based devices primarily rely on soft matrices,which revert to their original shapes and cease functioning when external magnetic fields are removed.Moreover,their magnetization programming,deformations,and functioning need to alternate between encoding and actuation platforms,limiting the adaptability and efficiency.Here,we present a reprogrammable magnetic shape-memory composite(RM-SMC)integrating a shape-memory polymer(SMP)skeleton with phase-transition magnetic microcapsules.High-intensity laser melts microcapsules for magnetic realignment under programmed fields,while low-intensity laser softens SMP for structural reconfiguration without compromising integrity.This dual-laser strategy facilitates in situ magnetization programming,shape morphing,and function execution within a single material system.Our innovative approach enables unique applications,including omnidirectional multi-degree-of-freedom actuators that can activate light switches,solar trackers that optimize energy capture,and adaptive impellers that modulate fluid pumping.By eliminating platform alternation and enabling shape/function retention post-actuation,the RM-SMC platform overcomes critical limitations in conventional MRCs,establishing a paradigm for multifunctional devices requiring persistent configuration control and field-independent operation. 展开更多
关键词 magneto-responsive composites shape memory polymer in situ programming and deformation omnidirectional multi-degree of freedom actuator adjustable fluid pumping
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“I’m Now Braver than Ever.”The Perceived Impacts of the Finnish“Gutsy Go”Program for Enhancing Adolescents’Psychosocial Well-Being:A Qualitative Study 认领 引用
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作者 Hanna Ahrnberg Kaija Appelqvist-Schmidlechner +2 位作者 Pekka Mustonen Sari Fröjd Katja Aktan-Collan 《International Journal of Mental Health Promotion》 2026年第4期93-108,共16页
Objectives:Positive Youth Development is an evidence-based,holistic approach that underlines adolescents’strengths,competence,and interests instead of deficits,thus promoting psychosocial well-being in adolescents.Th... Objectives:Positive Youth Development is an evidence-based,holistic approach that underlines adolescents’strengths,competence,and interests instead of deficits,thus promoting psychosocial well-being in adolescents.This study aims to explore adolescents’perceived impacts of the Finnish service-learning program“Gutsy Go”,which is based on a Positive Youth Development approach.Methods:The program educates 8th-grade comprehensive school students to perform good deeds in their communities and enhances adolescents’psychosocial well-being.Focus group interviews were conducted two to three weeks after the program week with 61 program participants.The data was analyzed using qualitative content analysis.Results:Four broad themes of the perceived impacts of the program were derived from the data:emotional impacts,impacts on competence,impacts within the group,and lessons learned for future use.Conclusions:The perceived impacts of the Gutsy Go program in this study were mostly positive and related to adolescents’psychosocial well-being.More studies are needed regarding the underlying mechanisms between participation in the program and the perceived impacts. 展开更多
关键词 Adolescence psychosocial well-being positive youth development school-based program service-learning
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