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Factors associated with acute kidney injury in rhabdomyolysis: Insights from a prospective study 认领 引用
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作者 Hiba Ghabi Amani Smai +7 位作者 Syrine Tlili Lamia Rais Fethi Ben Hmida Bouthaina Mesbahi Ines Bounaouas Ikram Mami Yosri Messaoudi Mouhamed Karim Zouaghi 《World Journal of Nephrology》 2026年第2期243-253,共11页
BACKGROUND Rhabdomyolysis is a common condition in intensive care units(ICUs),but data on acute kidney injury(AKI)associated with rhabdomyolysis remain limited,particularly in North Africa.AIM To determine the inciden... BACKGROUND Rhabdomyolysis is a common condition in intensive care units(ICUs),but data on acute kidney injury(AKI)associated with rhabdomyolysis remain limited,particularly in North Africa.AIM To determine the incidence of AKI during rhabdomyolysis and to identify its associated factors among ICU patients.METHODS We conducted a prospective,single-center correlational study from January to July 2024 in the ICU of Rabta University Hospital in Tunisia,including patients diagnosed with rhabdomyolysis.Clinical and laboratory parameters,along with the McMahon score,were assessed at the time of inclusion.Patients were then monitored during their ICU stay to detect the occurrence of AKI.RESULTS AKI occurred in 51.9%of the 54 patients included in the study.Univariate analysis identified several admission parameters associated with AKI,including elevated levels of creatine phosphokinase,lactate dehydrogenase(LDH),phosphorus,creatinine,and transaminases,as well as low bicarbonate and albumin levels.The optimal McMahon score threshold for predicting AKI was 4.75,with a sensitivity of 78.6%and specificity of 76.9%.In multivariate analysis,only initial LDH[P=0.012;odds ratio(OR)=0.993;95%CI:0.988-0.999]and initial bicarbonate(P=0.025;OR=1.553;95%CI:1.058-2.280)levels were independently associated with AKI occurrence.CONCLUSION Simple admission biomarkers such as LDH and bicarbonate should be considered for early AKI risk assessment in rhabdomyolysis,particularly in settings with limited access to advanced diagnostic tools. 展开更多
关键词 Acute kidney injury Factors Intensive care unit Prospective study Rhabdomyolysis
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Association of Body Mass Index with All-Cause Mortality and Cause-Specific Mortality in Rural China:10-Year Follow-up of a Population-Based Multicenter Prospective Study 认领 引用 被引量：1
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作者 Juanjuan Huang Yuanzhi Di +29 位作者 Lingyu Shen Jianguo Liang Jiang Du Xuefang Cao Weitao Duan Aiwei He Jun Liang Limei Zhu Zisen Liu Fang Liu Shumin Yang Zuhui Xu Cheng Chen Bin Zhang Jiaoxia Yan Yanchun Liang Rong Liu Tao Zhu Hongzhi Li Fei Shen Boxuan Feng Yijun He Zihan Li Yaqi Zhao Tonglei Guo Liqiong Bai Wei Lu Qi Jin Lei Gao Henan Xin 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2025年第10期1179-1193,共15页
Objective This study aimed to explore the association between body mass index(BMI)and mortality based on the 10-year population-based multicenter prospective study.Methods A general population-based multicenter prospe... Objective This study aimed to explore the association between body mass index(BMI)and mortality based on the 10-year population-based multicenter prospective study.Methods A general population-based multicenter prospective study was conducted at four sites in rural China between 2013 and 2023.Multivariate Cox proportional hazards models and restricted cubic spline analyses were used to assess the association between BMI and mortality.Stratified analyses were performed based on the individual characteristics of the participants.Results Overall,19,107 participants with a sum of 163,095 person-years were included and 1,910 participants died.The underweight(<18.5 kg/m2)presented an increase in all-cause mortality(adjusted hazards ratio[aHR]=2.00,95%confidence interval[CI]:1.66–2.41),while overweight(≥24.0 to<28.0 kg/m2)and obesity(≥28.0 kg/m2)presented a decrease with an aHR of 0.61(95%CI:0.52–0.73)and 0.51(95%CI:0.37–0.70),respectively.Overweight(aHR=0.76,95%CI:0.67–0.86)and mild obesity(aHR=0.72,95%CI:0.59–0.87)had a positive impact on mortality in people older than 60 years.All-2 cause mortality decreased rapidly until reaching a BMI of 25.7 kg/m(aHR=0.95,95%CI:0.92–0.98)and increased slightly above that value,indicating a U-shaped association.The beneficial impact of being overweight on mortality was robust in most subgroups and sensitivity analyses.Conclusion This study provides additional evidence that overweight and mild obesity may be inversely related to the risk of death in individuals older than 60 years.Therefore,it is essential to consider age differences when formulating health and weight management strategies. 展开更多
关键词 Body mass index Mortality Overweight Prospective study Underweight
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Kitchen Ventilation Attenuate the Association of Solid Fuel Use with Sarcopenia: A Cross-Sectional and Prospective Study 认领 引用 被引量：1
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作者 Yinghao Yuchi Wei Liao +8 位作者 Jia Qiu Ruiying Li Ning Kang Xiaotian Liu Wenqian Huo Zhenxing Mao Jian Hou Lei Zhang Chongjian Wang 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2025年第4期511-515,共5页
Rapid population aging has led to an increased focus on age-related conditions such as sarcopenia.causing loss of muscle mass and strength[1,2]. Sarcopenia is associated with adverse outcomes,including falls, funct... Rapid population aging has led to an increased focus on age-related conditions such as sarcopenia.causing loss of muscle mass and strength[1,2]. Sarcopenia is associated with adverse outcomes,including falls, functional decline, frailty, and mortality, which can lower the quality of life and shorten lifespan[1,2]. 展开更多
关键词 rapid population aging functional decline cross sectional study sarcopenia prospective study population aging solid fuel use muscle mass
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Risk of progression to high-grade intraepithelial neoplasia and gastric cancer:A multi-center prospective study in Anhui Province,China 认领 引用 被引量：4
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作者 Ying-Ling Liu Jie Liu Ye-Tao Wang 《World Journal of Gastrointestinal Oncology》 SCIE 2025年第3期155-164,共10页
BACKGROUND Gastric cancer is one of the most common cancers worldwide,especially in East Asia.AIM To explore the clinical outcomes and progression-related factors of low-grade intraepithelial neoplasia(LGIN)in the gas... BACKGROUND Gastric cancer is one of the most common cancers worldwide,especially in East Asia.AIM To explore the clinical outcomes and progression-related factors of low-grade intraepithelial neoplasia(LGIN)in the gastric mucosa and provide valuable guidance for improving treatment efficacy.METHODS A total of 357 patients diagnosed with LGIN based on initial pathological examination in Anhui Provincial Hospital or three other medical consortium units between January 2022 and June 2024 were included.Among them,296 patients were followed up with endoscopic and biopsy pathology.Logistic regression was utilized to analyze the relevant risk factors for LGIN progression in the gastric mucosa.RESULTS The distribution sites of LGIN among the 357 patients were as follows:Gastric antrum(54.6%),gastric cardia(24.1%),gastric angulus(8.7%),gastric body(4.8%),gastric fundus(4.8%),and multiple sites(3.1%).Additionally,of the 357 patients with LGIN,112(31.4%)developed ulceration and 59(16.5%)experienced gastric polyps.Furthermore,231 of the 357(64.71%)patients with LGIN tested positive for Helicobacter pylori(H.pylori)infection.The H.pylori infection rates of the patients with LGIN with accompanying atrophy,intestinal metaplasia,and gastric ulcer were 51.95%,59.31%,and 28.57%,respectively.Multivariate logistic regression analysis showed that age≥60 years[odds ratio(OR)=3.063,95%confidence interval(CI):1.351-6.945,P=0.007],H.pylori infection(OR=3.560,95%CI:1.158-10.949,P=0.027),multiple locations(OR=10.136,95%CI:2.045-50.237,P=0.005),lesion size≥2 cm(OR=3.921,95%CI:1.664-9.237,P=0.002),and gastric ulcer(OR=2.730,95%CI:1.197-6.223,P=0.017)were predictive factors for LGIN progression.CONCLUSION LGIN progression is closely related to age,H.pylori positivity,multiple locations,lesion size≥2 cm,and gastric ulcer.Thus,actively identifying these risk factors in patients with LGIN may have certain clinical significance in preventing further tumor progression. 展开更多
关键词 Low-grade intraepithelial neoplasia Gastric cancer Progression Risk factor Prospective study
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Prospective study on the impact of parental anxiety on academic performance in children with attention deficit 认领 引用
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作者 Yan Jin Yun-Shi Xiao Ping Zhou 《World Journal of Psychiatry》 SCIE 2025年第12期350-362,共13页
BACKGROUND Attention deficit hyperactivity disorder(ADHD)affects approximately 5%of children worldwide and is associated with significant academic impairment.Parents of children with ADHD experience elevated stress an... BACKGROUND Attention deficit hyperactivity disorder(ADHD)affects approximately 5%of children worldwide and is associated with significant academic impairment.Parents of children with ADHD experience elevated stress and anxiety levels,which may further affect their children's educational outcomes.This prospective study examined the relationship between parental anxiety and academic performance of children with ADHD over a 6-year period.AIM To investigate the longitudinal impact of parental anxiety on academic performance in children with ADHD and explore the mediating and moderating factors over a 6-year follow-up period.METHODS A longitudinal cohort study was conducted from 2018 to 2024,enrolling 118 children with ADHD(aged 6-12 years)and their parents from three specialized educational centers.Parental anxiety was assessed using the Parenting Stress Index-4(PSI-4)and Parental Anxiety Scale.Children's academic performance was measured using the Academic Performance Questionnaire and standardized achievement tests.Assessments were conducted at baseline and every 6 months for 3 years.RESULTS Higher parental anxiety scores were significantly associated with poorer academic performance in children with ADHD(β=-0.42,P85th percentile)showed 1.2 standard deviations lower academic achievement than children of parents with normal anxiety levels.The relationship was partially mediated by parent-child interaction quality(indirect effect=-0.18,95%CI:-0.26 to-0.10)and homework supervision practices(indirect effect=-0.15,95%CI:-0.22 to-0.08).CONCLUSION Parental anxiety could significantly affect the academic outcomes of children with ADHD via multiple pathways.Interventions targeting parental mental health may improve the educational outcomes of children with ADHD. 展开更多
关键词 Attention deficit hyperactivity disorder Parental anxiety Academic performance Prospective study Parent-child interaction
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Use of the UPOINT phenotype system in treating Chinese patients with chronic prostatitis/chronic pelvic pain syndrome:a prospective study 认领 引用 被引量：15
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作者 Xiao Guan Cheng Zhao +6 位作者 Zhen-Yu Ou Long Wang Feng Zeng Lin Qi Zheng-Yan Tang Jin-Geng Dun Long-Fei Liu 《Asian Journal of Andrology》 SCIE CAS CSCD 2015年第1期120-123,I0010,I0011,共4页
The urinary,psychosocial,organ-specific,infection,neurological/systemic and tenderness(UPOINT)phenotype system has been validated to be an effective phenotype system in classifying patients with chronic prostatitis/ch... The urinary,psychosocial,organ-specific,infection,neurological/systemic and tenderness(UPOINT)phenotype system has been validated to be an effective phenotype system in classifying patients with chronic prostatitis/chronic pelvic pain syndrome(CP/CPPS)in western populations.To validate the utility of the UPOINT system and evaluate the effect of multimodal therapy based on the UPOINT system in Chinese patients with CPICPPS,we performed this study.Chinese patients with CP/CPPS were prospectively offered multimodal therapy using the UPOINT system and re-examined after 6 months.A minimum 6-point drop in National Institutes of Health-Chronic Prostatitis Symptoms Index(NIH-CPSI)was set to be the primary endpoint.Finally,140 patients were enrolled in the study.The percentage of patients with each domain was 59.3%,45.0%,49.3%,22.1%,37.9%,and 56.4%for the UPOINT,respectively.The number of positive domains significantly correlated with symptom severity,which is measured by total NIH-CPSI scores(r=0.796,P〈0.001).Symptom duration was associated with a greater number of positive domains(r=0.589,P〈0.001).With 6 months follow-up at least,75.0%(105/140)had at least a 6-point improvement in NIH-CPSI after taking the therapy.All NIH-CPSI scores were significantly improved from original ones:pain 10.14±4.26 to 6.60±3.39,urinary 6.29±2.42 to 3.63±1.52,quality of life 6.56±2.44 to 4.06±1.98,and total 22.99±7.28 to 14.29±5.70(all P〈0.0001).Our study indicates that the UPOINT system is clinically feasible in classifying Chinese patients with CP/CPPS and directing therapy. 展开更多
关键词 chronic pelvic pain syndrome chronic prostatitis drug therapy prospective study UPOINT
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Peanut consumption and reduced risk of colorectal cancer in women:A prospective study in Taiwan 认领 引用 被引量：6
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作者 Chih-Ching Yeh San-Lin You +1 位作者 Chien-Jen Chen Fung-Chang Sung 《World Journal of Gastroenterology》 SCIE CAS 2006年第2期222-227,共6页
AIM： To examine whether peanut consumption is associated with a reduced risk of colorectal cancer in a prospective cohort with a 10-year follow-up. METHODS： In 1990-1992, residents （12026 men and 11917 women aged 3... AIM： To examine whether peanut consumption is associated with a reduced risk of colorectal cancer in a prospective cohort with a 10-year follow-up. METHODS： In 1990-1992, residents （12026 men and 11917 women aged 30 to 65 years） in 7 townships, Taiwan, were interviewed and recruited into a cancerscreening cohort and annually followed up. Colorectal cancer cases in this cohort were identified from cancer registry and death certificates. Incidence rates of this disease by the end of 2001 were calculated by gender for the primary study variable and covariates. The dietary intake was assessed by means of weekly food frequency measures, including frequently consumed food groups and folk dishes including sweet potato, bean products, peanut products, pickled foodstuffs, nitrated or smoked foodstuffs. RESULTS： During the study period, 107 new colorectal cancer cases （68 men and 39 women） were confirmed. The multivariate Cox＇s proportional hazard model showed that the relative risk （RR） of peanut consumption was 0.73 [95% confidence interval （CI） = 0.44-1.21] for men and 0.42 （95% CI = 0.21-0.84） for women. However, frequent intake of pickled foodstuffs was harmful for women （RR= 2.15, 95% CI=0.99-4.65）. The risk of colorectal cancer was also elevated among cigarette smokers but not significant （P〈 0.05）.CONCLUSION： This study suggests that frequent intake of peanut and its products may reduce colorectal cancer risk in women, demonstrating the anti-proliferating effect of peanut intake. 展开更多
关键词 Peanuts Colorectal cancer Diet Gender difference Prospective study Taiwan
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Combined Effects of Family History of Cardiovascular Disease and Serum C-reactive Protein Level on the Risk of Stroke: A 9.2-year Prospective Study among Mongolians in China 认领 引用 被引量：3
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作者 ZHU Zheng Bao HUANGFU Xin Feng +8 位作者 ZHONG Chong Ke ZHOU Yi Peng TIAN Yun Fan BUREN Batu XU Tian WANG Ai Li LI Hong Mei ZHANG Ming Zhi ZHANG Yong Hong 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2017年第9期632-640,共9页
Objective We aimed to evaluate the combined effect of a family history of cardiovascular disease（CVD） and high serum C‐reactive protein（CRP） on the stroke incidence in an Inner Mongolian population in China. Meth... Objective We aimed to evaluate the combined effect of a family history of cardiovascular disease（CVD） and high serum C‐reactive protein（CRP） on the stroke incidence in an Inner Mongolian population in China. Methods A prospective cohort study was conducted from June 2002 to July 2012, with 2,544 participants aged 20 years and over from Inner Mongolia, China. We categorized participants into four groups based on the family history of CVD and CRP levels. Results We adjusted for age; sex; smoking; drinking; hypertension; body mass index; waist circumference; and blood glucose, triglycerides, low‐density lipoprotein cholesterol, and high‐density lipoprotein cholesterol levels. Compared with the group with no family history of CVD/low CRP levels, the group with family history of CVD/high CRP levels had a hazard ratio（HR） of 1.78 [95% confidence interval（CI）, 1.03‐3.07; P = 0.039] of stroke, and an HR of 2.14（95% CI, 1.09‐4.20; P = 0.027） of ischemic stroke. The HRs of hemorrhagic stroke for the other three groups were not statistically significant（all P 〉 0.05）. Conclusion Participants with both a family history of CVD and high CRP levels had the highest stroke incidence, suggesting that high CRP levels may increase stroke risk, especially of ischemic stroke, among individuals with a family history of CVD. 展开更多
关键词 Family history of cardiovascular disease C‐reactive protein Stroke Prospective study
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Characteristics and Risk factors of Psychosomatic Symptoms Related to Female Tubal Sterilization in Rural Area in Hunan Province, China: A Prospective Study 认领 引用
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作者 刘破资 岳伟华 +9 位作者 郝伟 杨德森 凌天牖 张友明 彭光辉 武昆 刘红华 苏中华 王厚亮 谢永标 《Journal of Reproduction and Contraception》 2002年第1期37-52,共16页
Objectives To study characteristics of psychosomatic symptoms related to sterilization, to find out risk factors and their roles ascribed to psychosomatic symptoms, and to establish a mathematic model for screening ou... Objectives To study characteristics of psychosomatic symptoms related to sterilization, to find out risk factors and their roles ascribed to psychosomatic symptoms, and to establish a mathematic model for screening out susceptible women. Methods: This study enrolled 776 women in rural area at three counties of Linxiang, Qiyang, Changsha of Hunan province in China between February 1990 and April 1992. Brief Neurosis Screening Scale (BNSS), Symptom Checklist 90 (SCL-90), sensitivity to pain, suggestibility were used to indicate subjects' psychological status. Logistic regression model and retrograde discriminant analysis were applied to develop a mathematical model. Results: Prevalence of psychosomatic reactions or symptoms was 54.8% before sterilization, 26.6% at three months and 16.4% at one year after operation respectively. Psychosomatic symptoms were verified to be the result of joint effects of multiple risk factors. The following risk factors were associated with postoperative symptoms: anger-hostility (RR=33.71), high suggestibility (RR=4.53), high neuroticism (RR=3.44), sensitivity to pain (RR=2.14) and operative sites (RR=2.05). A mathematical model to estimate the probability of developing psychosomatic symptoms in sterilization was established.Conclusions: More than half of women suffered from psychosomatic reactions before operation, and some of them did not recover after operation. The postoperative psychosomatic symptoms are the joint effect of multiple risk factors. 展开更多
关键词 female tubal sterilization psychosomatic symptom susceptible prospective study
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A FIVE-YEAR PROSPECTIVE STUDY ON THE RELATIONSHIP BETWEEN GARLIC AND GASTRIC CANCER 认领 引用
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作者 许海修 孙汭 +1 位作者 聂洪洲 陈爱国 《Chinese Journal of Cancer Research》 CAS 1989年第4期63-65,共3页
A prospective study on the relationship between garlic and gastric cancer of 4552 subjects was made from Oct., 1980 through 1985. The volunteers, aged 50-59, were healthy males and came from different incidence areas ... A prospective study on the relationship between garlic and gastric cancer of 4552 subjects was made from Oct., 1980 through 1985. The volunteers, aged 50-59, were healthy males and came from different incidence areas of gastric cancer where they lived for long periods. The result of this study showed that the death rates of gastric cancer in 500 g groups of annual garlic intake were 10.40/ 10000 and 0, respectively. The relative risk of gastric cancer was significantly much higher in the former than in the latter, and showed a dose-response relationship. Protective effect of garlic for the population equal annual garlic intake was roughly the same in different districts. It was further confirmed that garlic played important role in preventing gastric cancer and had no regional differences. 展开更多
关键词 A FIVE-YEAR PROSPECTIVE STUDY ON THE RELATIONSHIP BETWEEN GARLIC AND GASTRIC CANCER
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Quality of life after colorectal surgery:A prospective study of patients compared with their spouses 认领 引用 被引量：1
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作者 Gökçe Aylaz Cihangir Akyol +4 位作者 Akın Fırat Kocaay Derya Gökmen Ayşe Burcu Yavuzarslan Ayhan Bülent Erkek Mehmet Ayhan Kuzu 《World Journal of Gastrointestinal Surgery》 SCIE 2021年第9期1050-1062,共13页
BACKGROUND Although radical surgery for colorectal cancer improves the oncological outcomes,a significant portion of patients suffer from alterations in their quality of life(QoL).There are many studies investigating ... BACKGROUND Although radical surgery for colorectal cancer improves the oncological outcomes,a significant portion of patients suffer from alterations in their quality of life(QoL).There are many studies investigating the QoL of patients who have colorectal cancer but none of these focus on the QoL of spouses.AIM To compare the QoL of patients after colorectal surgery to the QoL of spouses.METHODS This prospective study consisted of patients who were married and who underwent surgery at the University of Ankara,Department of Surgery between March 2006 and November 2010.Patients’spouses were also enrolled.The study was approved by the Ethics Committee of the Faculty of Medicine,Ankara University,and all patients provided written informed consent.The study included patients who underwent curative surgery for colorectal carcinoma[n=100;abdominoperineal excision(n=33),low anterior resection(n=33),left hemicolectomy(n=34)]and their spouses(n=100).The patients and spouses completed the Medical Outcome Study 36-item Short Form Survey(SF-36)and the World Health Organization Disability Assessment Schedule II(WHODAS-II)preoperatively and at postoperative months 15 to 18.RESULTS During this 4.5-year study period,273 patients with sigmoid or rectal cancer were admitted to the hospital.Of these patients,119 were eligible and willing to participate.Eleven patients had either systemic or locally inoperable disease,three patients had a severe surgical complication,and five patients were lost to followup.Therefore,a total of 100 patients completed the follow-up period.There was a statistically significant positive correlation between the disability scores of patients and the scores of their spouses for some of the WHODAS-II subscales,such as“self-care,”“life activities,”and“participation in society,”as well as for the total WHODAS-II score.There was also a positive correlation between the QoL of patients and the QoL of their spouses in most of the SF-36 subscales.Statistically significant correlations were observed for the“bodily pain,”“general health,””vitality,”“social function,”“emotion,”“mental health,”and mental component summary score subscales of the SF-36.When gender differences were evaluated,the QoL of male patients’spouses changed more when compared with female patients’spouses for all of the WHODAS-II subscales.Colorectal cancer surgery has a significant effect on the QoL of both patients and their spouses,these effects were more significant among male patients’spouses.CONCLUSION Preoperative counseling regarding potential problems should therefore collectively address patient and their spouse as a couple rather than the patient alone,particularly for patients undergoing low anterior resection and abdominoperineal resection procedures. 展开更多
关键词 Quality of life Colorectal surgery Patients'spouses Prospective study Male spouses Preoperative counseling
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Arthroscopic findings after manipulation under anesthesia in idiopathic capsulitis of the shoulder:A prospective study 认领 引用 被引量：1
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作者 Sai Krishna Mlv Ravi Mittal Nitin Chauhan 《World Journal of Clinical Cases》 SCIE 2023年第34期8147-8152,共6页
BACKGROUND Manipulation under anesthesia(MUA)of the shoulder joint is a commonly used method for the treatment of adhesive capsulitis.Though it has been known to be associated with a variety of complications,there is ... BACKGROUND Manipulation under anesthesia(MUA)of the shoulder joint is a commonly used method for the treatment of adhesive capsulitis.Though it has been known to be associated with a variety of complications,there is a paucity of studies describing the arthroscopic findings after MUA.AIM To describe the arthroscopic findings in patients with idiopathic adhesive capsulitis of the shoulder after MUA.METHODS We recruited 28 patients with idiopathic adhesive capsulitis who underwent arthroscopic capsular release.Manipulation of the shoulder was performed under anesthesia in all of these patients before capsular release.Intra-articular findings were recorded during arthroscopic capsular release in these patients.RESULTS All patients showed the presence of synovitis.Twenty-seven patients showed tears in the capsule on the anterior aspect.One patient had an avulsion of the anterior rim of the glenoid and labrum following the manipulation.Four patients had partial rotator cuff tears,and one patient showed a superior labrum anterior posterior lesion,which was not diagnosed preoperatively on magnetic resonance imaging.CONCLUSION MUA leads to rupture of the capsule,which is the desired outcome.However,the site of rupture of the capsule is dependent on the maneuvers of MUA.In addition,partial tears of the rotator cuff and osteochondral fractures of the glenoid can also occur. 展开更多
关键词 Frozen shoulder Arthroscopy Manipulation under anesthesia Prospective study
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THE PROSPECTIVE STUDY OF RELATIONSHIP BETWEEN LOW SELENIUM AND KASHIN-BECK DISEASE 认领 引用
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作者 郭雄 丁德修 +5 位作者 曾令霞 于志道 陈风石 赵增勤 王玖姓 毕华银 《Journal of Pharmaceutical Analysis》 CAS 1999年第1期2-8,19,共7页
The relationship of causeresult between low selenium (Se) and KashinBeck disease (KBD) was probed by the prospective study of epidemiological method with regarding lowSe as an exposure factor in this paper. 597 health... The relationship of causeresult between low selenium (Se) and KashinBeck disease (KBD) was probed by the prospective study of epidemiological method with regarding lowSe as an exposure factor in this paper. 597 healthy children lived in KBD areas with low, middle and high prevalence were divided into the lowSe exposed group and the nonlowSe exposed group according to their Se content in hair. The lowSe exposed group was divided into three subgroups, such as Se content in hair110 ng/g, 110 ng/g<Se content in hair150 ng/g and 150 ng/g<Se content in hair200 ng/g, respectively. Six new cases of the total with KBD (incidence was 0574% personyear) were found in the lowSe exposed group during three years period of the investigation. No new case was found in the non lowSe exposed group . KBD incidence was not significantly different between those two groups. Two new cases were found in children with Se content in hair kept below 110 ng/g during three years (incidence: 121% personyear). SMR in each group indicated that the new cases observed in the lowSe exposed group was remarkable lower than the new cases expected. It was not observed that the doseresponse relationship between lowSe and KBD, and was not supported that the lowSe was a predominant factor to cause KBD. 展开更多
关键词 KashinBeck disease selenium new case prospective study
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Effect of Tongluo Shenggu Prescription on ARCO Stage Ⅱ non-traumatic femoral head necrosis: A prospective study 认领 引用
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作者 Chen Yang Gao-Kui Zhang +3 位作者 Xue-Chao Yuan Wen-Xing Yu Yang-Quan Hao Chao Lu 《Journal of Hainan Medical University》 CAS 2020年第24期23-27,共5页
Objective:To observe the clinical results and therapeutic characteristics of Tongluo Shenggu Decoction in the treatment of ARCOⅡnon-traumatic femoral head necrosis.Methods:120 patients with ARCOⅡnon-traumatic femora... Objective:To observe the clinical results and therapeutic characteristics of Tongluo Shenggu Decoction in the treatment of ARCOⅡnon-traumatic femoral head necrosis.Methods:120 patients with ARCOⅡnon-traumatic femoral head necrosis from January 2016 to January 2017 were studied by prospective matched and controlled design.60 cases in the treatment group were treated with Tongluo Shenggu Formula.The control group(60 cases)received high energy extracorporeal shock wave therapy.The imaging stability rate,Harris score and SF-36 score were used as clinical efficacy indicators,followed up for 24 months,and the follow-up results were statistically analyzed.Results:Among the 120 patients,5 fell off and the rest were followed up.The imaging stability rate is heavy.The imaging stability rate of the patients in the treatment group is 78.95%,while that in the control group is 72.41%.The two groups have the same stability rate(P>0.05).In Harris score,the Harris score of the patients in the treatment group was 92.678.45 points,significantly higher than that of the control group(80.3924.65 points),the difference was statistically significant(p0.05).In Harris score,the Harris score of the patients in the treatment group was 92.678.45 points,significantly higher than that of the control group(80.3924.65 points),the difference was statistically significant(p<0.05),and the pain degree,joint function and joint deformity score of the treatment group were better than those of the control group(p<0.05).In the SF-36 score,the scores of physiological function,physiological function,physical pain,overall health,social function and emotional function in the treatment group were significantly higher than those in the control group,the difference was statistically significant(p<0.05).the incidence of adverse events in the treatment period of the two groups was lower and the patients could relieve themselves in the later stage.Conclusion:Tongluo Shenggu prescription has definite curative effect in treating ARCOⅡnon-traumatic femoral head necrosis,especially in improving hip joint function,relieving hip joint pain and improving quality of life. 展开更多
关键词 Tongluo Shenggu prescription ARCO II Stage Non-traumatic necrosis of femoral head Extracorporeal shock wave Prospective study
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Interferon plus ribavirin and interferon alone in preventing hepatocellular carcinoma: A prospective study on patients with HCV related cirrhosis 认领 引用 被引量：3
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作者 Francesco Azzaroli Esterita Accogli +12 位作者 Giovanni Nigro Davide Trerè Silvia Giovanelli Anna Miracolo Francesca Lodato Marco Montagnani Mariarosa Tamé Antonio Cloecchia Constance Mwangemi Davide Festi Enrico Roda Massimo Derenzini Giuseppe Mazzella 《World Journal of Gastroenterology》 SCIE CAS 2004年第21期3099-3102,共4页
AIM:To determine the role of interferon(IFN)with or withoutribavirin in preventing or delaying hepatocellular carcinoma(HCC)development in patients with hepatitis C virus(HCV)related cirrhosis.Data on the preventive e... AIM:To determine the role of interferon(IFN)with or withoutribavirin in preventing or delaying hepatocellular carcinoma(HCC)development in patients with hepatitis C virus(HCV)related cirrhosis.Data on the preventive effect of IFN plusribavirin treatment are lacking.METHODS:A total of 101 patients(62 males and 39 females,mean age 55.1±1.4 years)with histologically proven HCVrelated liver cirrhosis plus compatible biochemistry andultrasonography were enrolled in the study.Biochemistryand ultrasonography were performed every 6 mo.Ultrasoundguided liver biopsy was performed on all detected focallesions.Follow-up lasted for 5 years.Cellular proliferation,evaluated by measuring Ag-NOR proteins in hepatocytesnuclei,was expressed as AgNOR-Proliferative index(AgNOR-PI)(cut-off=2.5).Forty-one patients(27 males,14 females)were only followed up after the end of anyearly treatment with IFN-alpha2b(old treatment controlgroup=OTCG).Sixty naive patients were stratified accordingto sex and AgNOR-PI and then randomized in two groups:30 were treated with IFN-alpha2b+ribavirin(treatmentgroup=TG),the remaining were not treated(control group=CG).Nonresponders(NR)or relapsers in the TG receivedfurther IFNibavirin treatments after a 6 mo of withdrawal.RESULTS:AgNOR-PI was significantly lowered by IFN(P2.5(26% vs3%,P<0.01).Two NR in the OTCG,none in the TG and 9 patients in the CG developed HCCduring follow-up.The Kaplan-Mayer survival curves showedstatistically significant differences both between OTCG andCG(P<0.004)and between TG and CG(P<0.003).CONCLUSION:IFNibavirin treatment associated with re-treatment courses of NR seems to produce the best resultsin terms of HCC prevention.AgNOR-PI is a useful markerof possible HCC development. 展开更多
关键词 Antineoplastic Agents dosage Antiviral Agents Carcinoma, Hepatocellular control Drug Therapy, Combination Female Hepatitis C, Chronic Humans Interferons Liver Cirrhosis Liver Neoplasms Male Middle Aged Nucleolus Organizer Region Prospective Studies Ribavirin Silver Staining
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Young adulthood adiposity in relation to all-cause and cause-specific mortality:a prospective study of 0.5 million Chinese adults 认领 引用
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作者 Lei Fan Andri Iona +16 位作者 Shixian Feng Gang Zhou Huarong Sun Pang Yao b Canqing Yu Yiping Chen Dianjianyi Sun Pei Pei Ling Yang Mingshu Yan Xiaoming Yang Jun Lv Junshi Chen Liming Li Zhengming Chen Huaidong Du the China Kadoorie Biobank Collaborative Group 《Science Bulletin》 SCIE EI CAS CSCD 2026年第7期1760-1770,共11页
Obesity is a well-established risk factor for early death,but the exact shapes of associations between young adulthood body mass index(BMI)and mortality in later life were not well characterised.Using data from the pr... Obesity is a well-established risk factor for early death,but the exact shapes of associations between young adulthood body mass index(BMI)and mortality in later life were not well characterised.Using data from the prospective China Kadoorie Biobank study of 430,373 participants(∼57%being women,with a median follow-up duration of 12 years),Cox regression analysis was performed to yield adjusted hazard ratios(HRs)relating BMI at∼25 years old(BMI25)with different mortality outcomes including total mortality(n=36,814),cardiovascular mortality(n=13,620),cancer mortality(n=13,394)and respiratory mortality(n=2929).Mean BMI25of participants was 21.9(SD=2.5)kg/m2,and 1.9%participants were obese at young adulthood(i.e.,BMI25≥28.0 kg/m2).Independent of baseline BMI,higher BMI25was associated with much higher levels of blood glucose and diabetes prevalence at baseline.After adjusting for potential confounders e.g.,age,smoking,and baseline measured BMI,BMI25had a strong positive log-linear association with all above-mentioned mortality outcomes,those being obese at young adulthood had a HR of 1.85(95%CI:1.75–1.95),1.85(1.71–2.00),1.40(1.26–1.56)and 2.34(1.96–2.81),respectively,compared with participants having BMI25of 18.5–20.0 kg/m2.The association with cancer mortality was more pronounced in men than in women,but no such heterogeneity was observed for total,cardiovascular diseases(CVD),and respiratory mortality.To conclude,the observed strong monotonically positive associations between young adulthood BMI and various mortality outcomes,independent of BMI in later life,support the need for early and stringent body weight control to prevent early death. 展开更多
关键词 Young adulthood adiposity Mortality Prospective study China
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Residential greenness,air pollution,and incident age-related macular degeneration:A prospective cohort study 认领 引用
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作者 Jiali Wang Yinyan Gao +2 位作者 Yijuan Lin Irene X.Y.Wu Fang Xiao 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第1期242-249,共8页
Existing evidence suggests residential greenness is beneficial to human,while no research to date explored the associations of greenness with age-related macular degeneration(AMD).To evaluate the association of greenn... Existing evidence suggests residential greenness is beneficial to human,while no research to date explored the associations of greenness with age-related macular degeneration(AMD).To evaluate the association of greenness with AMD,modification and mediation effect of air pollution,we conducted this prospective study.We con-structed weighted quantile sum(WQS)index as co-exposure to nitrogen oxides(NOx),particulate matter<2.5μm(PM2.5),particulate matter<10μm(PM10).Stratified Cox regression models were applied to test the effect of exposure.Effect modification of air pollution was assessed.Stratified Cox models through the indirect method and Aalen additive risk models were used in mediation analysis.Over median follow-up of 11.67 years,4596 AMD events were ascertained.Hazard ratios(HRs)and 95%confidence intervals(95%CIs)of incident AMD for pollution per interquartile range(IQR)increment were 1.10(1.04–1.16)for nitrogen dioxide(NO2),1.09(1.03–1.15)for NOx,1.14(1.05–1.24)for PM2.5,1.13(1.05–1.21)for PM10.The HR(95%CI)of AMD associated with greenness 1000 m buffer per IQR increment was 0.91(0.86–0.97),300 m buffer was 0.94(0.89–0.99).The as-sociation between greenness 1000 m and AMD was 28.59%,44.77%,35.59%,32.31%and 27.08%mediated by the decreased WQS index,NO2,NOx,PM2.5 and PM10,respectively.Increased greenness was associated with lower AMD incidence,and air pollution partly mediate it,which implies that interventions aimed at improving air quality and increasing greenness could have a dual benefit in mitigating AMD risk. 展开更多
关键词 Age-related macular degeneration(AMD) Residential greenness Ambient air pollution Mediation effect Prospective cohort study
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Solid fuel use and heart disease in middle-aged and older Chinese populations:a prospective cohort study 认领 引用
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作者 Jun-Wen WANG Ke-Xin CHEN +8 位作者 Teng HU Yu-Yang YE Yi-Fei ZHAO Xin-Ru HU Jiang YU Simayi Abulikemu Mai-Lin WEI Jun MA Yong PENG 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2026年第2期100-112,共13页
BACKGROUND Solid fuel use for cooking and heating is a major environmental risk factor,yet its association with new-onset heart disease(HD)remains unclear.The aim of this study was to investigate the relationship betw... BACKGROUND Solid fuel use for cooking and heating is a major environmental risk factor,yet its association with new-onset heart disease(HD)remains unclear.The aim of this study was to investigate the relationship between solid fuel exposure and new-onset HD in a large cohort.METHODS Multivariable logistic regression models assessed associations between cooking/heating fuel types(coal,crop residue/wood,liquefied petroleum gas,natural gas,and others)and new-onset HD.Subgroup analyses explored effect modification by age,sex,education,smoking,alcohol use,and region.RESULTS A prospective cohort study included 5915 participants,with 781 participants(13.2%)developing new-onset HD.Coal use for cooking showed an initial association with new-onset HD risk(OR=1.41,95%CI:1.06–1.86,P=0.02),which attenuated after full adjustment(OR=1.28,95%CI:0.96–1.72,P=0.10).Coal use for heating demonstrated robust associations across all models(OR=1.86,95%CI:1.42–2.43,P<0.001).Crop residue/wood burning for heating was also significant(Model 2:OR=1.40,95%CI:1.06–1.86,P=0.02).Subgroup analyses revealed stronger associations among females,non-smokers,non-drinkers,and less-educated participants.Geographic stratification showed significant associations in southern but not northern regions.CONCLUSIONS Solid fuel use,particularly coal for heating,is associated with increased new-onset HD risk.Reducing solid fuel exposure is crucial for HD prevention in low-resource settings. 展开更多
关键词 petroleum gasnatural gasand solid fuel multivariable logistic regression models older populations middle aged heart disease prospective cohort study effect modificatio
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Association of Planetary Health Diet with Decreased Risk of All-cause Mortality and Environmental Benefits:Insights from a Multi-national Prospective Cohort Study 认领 引用
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作者 Xi Li Liyuan Tao Jue Liu 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2026年第4期476-481,共6页
Whether adherence to the Planetary Health Diet(PHD)benefits human and environmental health is less known.We included 131,130 adults from the National Health and Nutrition Examination Survey and UK Biobank.Adherence to... Whether adherence to the Planetary Health Diet(PHD)benefits human and environmental health is less known.We included 131,130 adults from the National Health and Nutrition Examination Survey and UK Biobank.Adherence to the PHD was measured using the Planetary Health Diet Index(PHDI)and mortality was ascertained by linking to national registries.Cox proportional hazards and linear/ordinal logistic regression models were used to analyze the association between PHD and the risk of mortality and environmental impacts,respectively. 展开更多
关键词 environmental benefits multi national prospective cohort study UK Biobank linking national registriescox proportional hazards mortality planetary health diet planetary health diet phd benefits National Health Nutrition Examination Survey
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Association between Urinary Cobalt and All-cause and Cause-specific Mortality among Chinese Older Adults:A Prospective Cohort Study 认领 引用
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作者 Yudong Wu Yongqiang Chen +20 位作者 Chen Chen Liang Ding Linsen Yang Kai Zhang Xi Meng Wenhui Shi Yang Li Jiahao Chen Yue Chen Yingli Qu Wanying Shi Ziyu Hu Fanye Long Lijun Wang Luxi Wei Jinhui Zhou Feng Zhao Ying Zhu Maigeng Zhou Yuebin Lyu Xiaoming Shi 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2026年第6期690-702,共13页
Objective To investigate the association between urinary cobalt levels and all-cause and cause-specific mortality in older Chinese adults.Methods This study enrolled older adults(≥60 years)from two cohorts.Urinary co... Objective To investigate the association between urinary cobalt levels and all-cause and cause-specific mortality in older Chinese adults.Methods This study enrolled older adults(≥60 years)from two cohorts.Urinary cobalt concentrations were quantified using inductively coupled plasma mass spectrometry.Mortality outcomes were ascertained by linking them to the Chinese Disease Surveillance Point System.Cox proportional hazards models were used to evaluate the association between urinary cobalt and mortality,and subgroup analyses were performed to identify vulnerable populations.Results A total of 9,727 participants were followed for an average of 4.754 years,during which 2,745 deaths were recorded.Participants with the highest urinary cobalt concentration had a 29%greater allcause mortality risk(HR:1.292,95%CI:1.155–1.445)than those in the lowest quartile,along with significantly elevated mortality from cardiovascular(24.8%),neurological(137.1%).Subgroup analyses revealed that female,Han Chinese individuals,and rural residents were more susceptible to the effects of cobalt.Conclusion Cobalt exposure was associated with elevated all-cause,cardiovascular,and neurological mortality in older adults,with female,Han ethnicity,and rural residents being vulnerable groups.These findings provide population-based evidence for clinical management and policy revisions regarding cobalt exposure. 展开更多
关键词 Urine Cobalt Cause of death Prospective studies Elderly
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