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Advances in multi-omics and aging clock research for female reproductive health and aging 认领 引用
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作者 Rui Wang Yaqian Li Lan Zhu 《MedScience》 SCIE CAS CSCD 2026年第1期94-119,共26页
With the global increase in life expectancy,the aging of the female reproductive system has become a critical area of focus due to its profound implications for overall health and quality of life.Advances in multiomic... With the global increase in life expectancy,the aging of the female reproductive system has become a critical area of focus due to its profound implications for overall health and quality of life.Advances in multiomics technologies,encompassing epigenetics,transcriptomics,proteomics,metabolomics,and microbiomics,have provided transformative insights into the complex biology of female reproductive health and aging.Computational models called aging clocks,based on these approaches,enable the precise assessment of biological age,identification of tissue-specific vulnerabilities,and elucidation of systemic aging patterns.While multi-omics and aging clock research in the female reproductive tract remains an evolving field,the growing availability of high-quality studies and resources offers promising opportunities to advance our understanding of reproductive aging and other significant issues in female reproductive health,such as infertility and pregnancy complications. 展开更多
关键词 aging multi-omics aging clocks female reproductive tract female reproductive health
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Chronic sub-lethal exposure to clothianidin impacts reproductive fitness in Drosophila melanogaster 认领 引用 被引量：1
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作者 Sayantani Nanda Abhratanu Ganguly +2 位作者 Moutushi Mandi Kanchana Das Prem Rajak 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第4期728-742,共15页
Clothianidin is a neonicotinoid insecticide commonly employed in agricultural fields to kill or repel pests.Nonetheless,unintentional chronic exposure to this chemical may adversely affect reproductive fitness in nont... Clothianidin is a neonicotinoid insecticide commonly employed in agricultural fields to kill or repel pests.Nonetheless,unintentional chronic exposure to this chemical may adversely affect reproductive fitness in nontarget organisms.Hence,to understand the reproductive risks of clothianidin exposure,the present study was conducted to explore the chronic sub-lethal effects of clothianidin on the reproductive health of Drosophila melanogaster.Briefly,the first instar larvae of D.melanogaster were exposed to six sublethal concentrations(0.05–0.1μg/mL)of clothianidin till their adult stage.Notably,clothianidin exposure(0.07μg/mL)reduced fecundity and egg hatchability by 42.57%and 10.93%,respectively,in treated females.The test chemical also escalated subcellular ROS production by upregulating catalase,superoxide dismutase,and reduced glutathione levels.Moreover,oxidative damage to proteins and lipids was also evident.Tissue injuries were apparent in the gonads of both sexes.The investigation was extended to the subcellular level,where chronic exposure to clothianidin reduced glucose 6-phosphate dehydrogenase(G6PD),angiotensin-converting enzyme(AnCE),and vitellogenin activities in adult males by 53.65%,52.54%,and 43.44%,respectively,at 0.1μg/mL concentration.Likewise,in females,G6PD,AnCE,and vitellogenin activities were decreased by 52.63%,39.55%,and 36.06%,respectively.Additionally,mitoferrin and malate dehydrogenase activities were downregulated by 38.12%and 53.44%at 0.1μg/mL concentration.Hence,the findings of this study equivocally suggest that exposure to clothianidin at sub-lethal concentrations fuels oxidative stress and modulates reproductive mediators in D.melanogaster.Moreover,nuclear damage and tissue injuries in gonads can synergistically contribute to less fecundity and fertility in D.melanogaster. 展开更多
关键词 Pesticide Neonicotinoid Clothianidin Reproductive toxicity Oxidative stress
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Dietary glycyrrhizin enhances reproductive performance by improving intestinal microbiota,liver lipid metabolism and ovarian senescence in aged breeder hens 认领 引用 被引量：1
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作者 Zhenwu Huang Huchuan Liu +5 位作者 Guangju Wang Huan Ge Yanru Shi Jinghai Feng Chunmei Li Minhong Zhang 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2026年第1期299-317,共19页
Background The decline in reproductive performance of aged hens is mainly attributed to oxidative damage in reproductive organs,hepatic lipid metabolism disorders,and intestinal microbiota dysbiosis.Glycyrrhizin(GL)ha... Background The decline in reproductive performance of aged hens is mainly attributed to oxidative damage in reproductive organs,hepatic lipid metabolism disorders,and intestinal microbiota dysbiosis.Glycyrrhizin(GL)has been proven to enhance antioxidant capacity,regulate lipid metabolism and gut microbiota in mammals,but its efficacy in hens remains unclear.Hence,this study aimed to investigate whether dietary GL supplementation improves reproductive performance in hens during the late laying stage by modulating intestinal microbiota composition,hepatic lipid metabolism and ovarian antioxidant status.Results Dietary supplementation with 100 mg/kg GL significantly improved the egg production rate,egg quality,and hatching rate in aged breeder hens(P<0.05).GL supplementation also increased the serum levels of HDLC,TP and ALB,and enhanced the antioxidant capacity in both serum and ovary(P<0.05).In addition,dietary GL elevated the serum progesterone(P4)levels by enhancing the transcription level of steroid synthesis key enzymes(CYP11A1 and 3β-HSD)in the ovary(P<0.05).Dietary GL also promoted the synthesis and transport of vitellogenin(VTG)by upregulating the VTG-Ⅱ(P<0.05)and APOV1(P=0.077)expression levels in the liver,thereby increasing the number of grade follicles and small yellow follicles.Moreover,dietary GL enhanced hepatic fatty acidβ-oxidation by upregulating PPARαand CPT-I(P<0.05),and downregulating ACC expression levels(P<0.05).In agreement,liver metabolomics analysis revealed that dietary GL supplementation significantly altered hepatic metabolism,with 389 differentially identified metabolites(P<0.05).The key metabolites(e.g.,taurocholic acid,tauroursodeoxycholic acid,nicotinuric acid,glycodeoxycholic acid(hydrate))were identified,and they were mainly functionally enriched in betaalanine metabolism nicotinate,taurine and hypotaurine metabolism(P<0.05).Finally,16S rRNA gene sequencing revealed that dietary GL reversed age-induced changes in gut microbiota composition,characterized by a significant increase in Lactobacillus abundance and a decrease in Bacteroides(P<0.05).Conclusions These results collectively demonstrate that dietary supplementation with 100 mg/kg GL improved reproductive performance by reversing age-induced changes in gut microbiota,enhancing hepatic vitellogenin synthesis,and ameliorating ovarian function in aged breeder hens.This study suggests that dietary GL is a potential strategy to improve reproductive performance in broiler breeder hens during the late laying period. 展开更多
关键词 Aged breeder hen Glycyrrhizin Gut microbiota Lipid metabolism Reproductive performance
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Dissecting the genetic basis of reproductive transition and reproductive growth in wheat by considering accumulated temperature 认领 引用
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作者 Liujie Jin Kening Duo +4 位作者 Chao Fu Yunzhen Li Chao He Xin Gong Wenhao Yan 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2026年第3期544-546,共3页
The post-embryonic development of shoot apices in higher plants progresses through three distinct phases:the juvenile phase,adult vegetative phase,and reproductive phase.The transition from vegetative to reproductive ... The post-embryonic development of shoot apices in higher plants progresses through three distinct phases:the juvenile phase,adult vegetative phase,and reproductive phase.The transition from vegetative to reproductive growth represents a critical developmental transition that affects plant adaptability(Poethig 2003;Baurle and Dean 2006). 展开更多
关键词 juvenile phaseadult shoot apices higher plants accumulated temperature genetic basis reproductive transition developmental transition reproductive growth
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Whole genome sequencing analysis reveals strong reproductive isolation between two hybridizing Rhododendron species in subgenus Tsutsusi 认领 引用
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作者 Xiaoling Tian Ningning Zhang +5 位作者 Xiaohua Li Zhong Zhang Heng Shu Chunying Zhang Yongpeng Ma Yupeng Geng 《Plant Diversity》 SCIE CAS CSCD 2026年第1期212-215,共4页
Natural hybridization is known to play a vital role in speciation;however,the mechanisms underlying the early stages of natural hybridization remain unclear.Where two plant species come into contact,two driving forces... Natural hybridization is known to play a vital role in speciation;however,the mechanisms underlying the early stages of natural hybridization remain unclear.Where two plant species come into contact,two driving forces may balance the dynamic consequences of hybridization:fusion by hybridization-mediated gene flow,and separation by reproductive isolation(RI)(Ma et al.,2010a,b;Chang et al.,2022). 展开更多
关键词 Reproductive isolation Natural hybridization Rhododendron Mutation load Whole genome sequence
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Interpopulation Variation in Reproductive Strategies of Leymus chinensis Along Geographical Gradients in Northeast China:From Phenotypic Patterns to Adaptive Mechanisms 认领 引用
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作者 QI Wenwen LI Yaxiao +4 位作者 MA Hongyuan ZHAO Dandan LI Shaoyang YU Lingxue WU Haitao 《Chinese Geographical Science》 SCIE CAS CSCD 2026年第5期832-846,共15页
Geographic variation in plant functional traits plays a pivotal role in elucidating plant adaptive strategies,typically driven by both macro-climatic gradients and local-scale environmental heterogeneity.However,for c... Geographic variation in plant functional traits plays a pivotal role in elucidating plant adaptive strategies,typically driven by both macro-climatic gradients and local-scale environmental heterogeneity.However,for clonal plants,the role of reproductive allocation in shaping offspring fitness across geographic scales remains poorly understood.We investigated 30 Leymus chinensis populations in Northeast China in July 2021 and 2022 to examine geographic variation in growth,reproductive traits,and germination characteristics.The results revealed that:1)most growth and reproductive traits exhibited significant interpopulation variation but lacked broadscale geographic patterns,with the exception of ramet density(RD),which followed a longitude-influenced clumped distribution.This suggests that trait differentiation is primarily driven by local environmental heterogeneity rather than macro-climatic gradients.Sexual reproductive output(e.g.,heading rate and seed number)displayed high variability(Coefficient of variation,CV=0.71–0.87),whereas thousand seed weight(TSW)was highly conservative(CV=0.09).2)No global trade-off was observed between seed number(SN)and TSW;however,a context-dependent trade-off emerged in low-biomass populations,where TSW correlated positively with heading plant height(HPH)and negatively with reproductive allocation.3)Multivariate regression analysis indicated that the germination rate(GER)was significantly influenced by HPH(negative effect)and SN(positive effect),while mean germination time(MGT)was driven by aboveground biomass and flower number per spike.Notably,maternal reproductive allocation and fecundity(HPH and SN),rather than TSW,were the primary predictors of offspring fitness(GER).These findings suggest that Leymus chinensis optimizes offspring establishment through flexible resource allocation strategies.In conclusion,local habitat heterogeneity is the main driver of trait differentiation in Leymus chinensis populations,and maternal physiological‘pre-conditioning’via resource partitioning outweighs seed size in determining reproductive success. 展开更多
关键词 seed quality reproductive strategy seed germination adaptability spike-to-plant height ratio(SHR) Northeast China
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The effects of bisphenol compounds on endocrine disruption and reproductive function from epidemiological analysis to animal exposure:A mixture analysis 认领 引用
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作者 Peiyun Jiang Weiwei Wang +3 位作者 Jiande Li Yating Li Xiaotong Ji Huifeng Yue 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第2期537-547,共11页
Bisphenol F(BPF)and Bisphenol S(BPS)are widely used substitutes for Bisphenol A(BPA).However,growing evidence indicated that BPF and BPS may induce physiological effects similar to those of BPA.Furthermore,chemical ma... Bisphenol F(BPF)and Bisphenol S(BPS)are widely used substitutes for Bisphenol A(BPA).However,growing evidence indicated that BPF and BPS may induce physiological effects similar to those of BPA.Furthermore,chemical management and control is primarily focus on the risk assessment of individual compounds,often overlooking the implications of chemical mixtures.We hypothesize that exposure to a mixture of BPA and its substitutes will enhance their endocrine-disruptive effects,disrupt steroid hormone homeostasis,and further impair reproductive system functionality.In the animal study,both female and male mice were exposed to 333μg/kg of BPA,BPF,BPS,their mixture(333μg/kg(MIXL),and 1 mg/kg(MIXH))via gavage daily for four weeks.The study demonstrated that bisphenols(BPs)affected the expression of genes related to steroid hormone synthesis.The MIXL group of female mice exhibited an increasing trend in estradiol(E2)levels and a decreasing trend in progesterone(Pg)and testosterone(TT)levels.Additionally,follicular development was impacted,resulting in an increased number of atretic follicles.In contrast,a significant increase in E2 concentration and disruption of testicular morphology were observed in the MIXH group of male mice,accompanied by a decline in sperm quality.Importantly,these results were corroborated by a population-based investigation.Collectively,the animal experiments indicate that mixed exposure to BPs disrupts hormone levels and adversely affects reproductive function,while epidemiological evidence further establishes correlative links between bisphenols and hormone levels.These findings underscore the necessity of considering chemical mixtures during testing and risk assessment. 展开更多
关键词 Bisphenols Mixture exposure Animal experiments Steroid hormone synthesis Reproductive function Epidemiological studies
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HD-ZIP transcription factors:pivotal regulators of plant reproductive development 认领 引用
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作者 Jiakun Zheng Feng Wang +2 位作者 Yingxiao Mai Xingling Su Rui Xia 《Horticultural Plant Journal》 SCIE CAS CSCD 2026年第4期735-746,共12页
The HD-ZIP gene family,a group of plant-specific transcription factors,plays pivotal regulatory roles in various aspects of plant growth and development.Accumulating evidence has demonstrated the extensive involvement... The HD-ZIP gene family,a group of plant-specific transcription factors,plays pivotal regulatory roles in various aspects of plant growth and development.Accumulating evidence has demonstrated the extensive involvement of HD-ZIP members in regulating reproductive developmental processes.This review systematically summarizes both the structural characteristics of the four HD-ZIP subfamilies(Ⅰ-Ⅳ)and their distinct regulatory roles in plant reproductive development.Recent studies reveal that a conserved HD-ZIPⅠclade serves as a core regulator of key reproductive processes,ranging from spike development in monocots(e.g.,barley Vrs1 and maize GT1)to sex determination in dicots(e.g.,cucumber CmHB40 and persimmon MeGI).Meanwhile,members of other subfamilies(HD-ZIPⅡ-Ⅳ)contribute significantly to diverse reproductive processes including pistil development,floral organ formation,and anther development,among others.This review provides a comprehensive synthesis of HD-ZIP subfamily functions in reproductive development,integrating current knowledge while highlighting critical research gaps.These insights aim to provide theoretical foundations for functional characterization and potential applications of HDZIP reproductive regulators,while advancing our understanding of transcriptional regulation mechanisms in plant reproductive development. 展开更多
关键词 HD-ZIP Transcription factor HD-ZIPⅠ Reproductive development
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Transcriptome reveals probiotics mitigating MCLR-induced reproductive toxicity in male zebrafish:Regulation of reproductive endocrine,oxidative stress,and inflammatory response 认领 引用
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作者 Haoling Liu Wei Sang +8 位作者 Zixuan Liao Junli Zuo Ning Luan Xiaolin Liu Juan Chen Qing Yang Tien-Chieh Hung Qin Wu Guangyu Li 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第8期411-424,共14页
Microcystin-LR(MCLR)is widely distributed in aquatic ecosystems,exhibiting strong reproductive toxicity to male fish.Several previous studies have reported probiotics could mitigate reproductive system damage caused b... Microcystin-LR(MCLR)is widely distributed in aquatic ecosystems,exhibiting strong reproductive toxicity to male fish.Several previous studies have reported probiotics could mitigate reproductive system damage caused by environmental pollutants.Whether MCLR-induced negative effects on reproduction could be mitigated by probiotics and the mechanisms involved are little studied.In this study,adult male zebrafish(Danio rerio)received MCLR exposure for 28 days,supplemented or not with the probiotic Lactobacillus rhamnosus GG(LGG).The results showed MCLR exposure impaired male zebrafish reproductive function,evidenced by reduced sperm motility and density,and testicular damage;LGG supplementation mitigated these effects.To investigate the underlying mechanisms,we performed transcriptomic analysis and evaluated the protective effects of LGG in terms of reproductive endocrinology,oxidative stress and inflammatory responses.The results indicated LGG mitigated those injury in male zebrafish by regulating sex hormone synthesis genes,the Nrf2(NF-E2-related factor2)/ARE(antioxidant response element)pathway,and the TLR4(toll-like receptor 4)/NF-κB(nuclear factor-κB)pathway,respectively.Transcriptomic analysis provides evidence that apoptotic regulation may also contribute to the mitigation of MCLR-induced reproductive toxicity.The present study validates a new approach to effectively control the MCLR-induced reproductive toxicity. 展开更多
关键词 Microcystin-LR(MCLR) Lactobacillus rhamnosus GG Reproductive toxicity Oxidative stress Inflammatory response Apoptotic
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Fermented bamboo powder enhances testicular function and reproductive performance by modulating spermatogenesis,hormonal profiles,and autophagy in yellow-feathered roosters 认领 引用
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作者 Rahmani Mohammad Malyar Wei Ding +4 位作者 Jiahao Sun Shoura Hytham Elsaid Mohammad Bayer Darmel Yansen Li Fangxiong Shi 《Asian pacific Journal of Reproduction》 CAS 2026年第4期183-193,共11页
Objective:To investigate the effects of Fermented Bamboo Powder(FBP)supplementation on testicular development and reproductive performance in yellow-feathered roosters.Methods:A total of 300 roosters were randomly ass... Objective:To investigate the effects of Fermented Bamboo Powder(FBP)supplementation on testicular development and reproductive performance in yellow-feathered roosters.Methods:A total of 300 roosters were randomly assigned to two groups(n=150 per group)and subjected to a 77-day feeding trial.The control group received a standard basal diet,while the experimental group was fed the same basal diet supplemented with FBP in a stepwise dosing regimen:1.0 g/kg during Phase栺(days 1-22),2.0 g/kg during Phase栻(days 23-45),4.0 g/kg during Phase栿(days 46-60),and 6.0 g/kg during Phase桇(days 61-77).Testicular morphology and spermatogenesis were evaluated using hematoxylin and eosin staining and gonadosomatic index.Serum lipids and reproductive hormones were measured with assay kits and enzyme linked immunosorbent assay.Autophagy-related proteins were analyzed via Western blot,and spermatogenesis-related genes were quantified by quantitative real-time polymerase chain reaction.Results:FBP supplementation improved left testis width,length,and thickness,as well as right testis width(P<0.05).Both individual and total testis weights were markedly higher in the FBP group.Histological analysis revealed notable improvements in testicular architecture,including increased seminiferous tubule diameter,epithelial height,luminal area,and Johnsen’s score.At the molecular level,FBP upregulated mRNA expression of spermatogenesis-related genes such as CREM,PCK2,DDX4,GDNF,SPAG6,SPAG16,and SPAG17(P<0.05).There was a significant increase in total protein and a reduction in triglyceride concentrations.Hormonal evaluations indicated significantly elevated serum testosterone and FSH levels in the FBP group.Importantly,FBP enhanced the expression of autophagy-related proteins beclin-1 and ATG5,suggesting increased autophagic activity.Additionally,phosphorylated mTOR levels were significantly increased.Conclusions:FBP supplementation positively affects testicular morphometry,endocrine profiles,and molecular pathways involved in spermatogenesis and autophagy,supporting its potential role in improving male reproductive performance in poultry. 展开更多
关键词 Yellow-feather rooster Fermented bamboo powder Spermatogenesis Testicular histology Reproductive Performance
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Urbanization enhances the breeding performance but does not affect the reproductive success of Chinese Blackbird(Turdus mandarinus) 认领 引用
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作者 Zijing Liao Zhen Zhang +8 位作者 Long Ma Fengxi Hu Wenjing Lu Mingwang Chen Junpeng Bai Yuqing Han Peng Chen Chaoying Zhu Luzhang Ruan 《Avian Research》 SCIE CAS CSCD 2026年第2期249-258,共10页
Urbanization provides novel habitats for bird species,while simultaneously posing numerous threats to them.Although several bird species have successfully adapted to urbanization,the underlying adaptation mechanisms o... Urbanization provides novel habitats for bird species,while simultaneously posing numerous threats to them.Although several bird species have successfully adapted to urbanization,the underlying adaptation mechanisms of reproductive success remain poorly understood in rapidly urbanizing areas.To this aim,a total of 168 breeding pairs of the Chinese Blackbird(Turdus mandarinus)were monitored during the breeding season(March–July)from 2018 to 2023.We used environmental factors(including nest tree variables,and concealment variables),phenotypic characteristics of nestlings,number of nest predation events,and quantiffiified urbanization scores to understand the impact of urbanization on breeding performance of Chinese Blackbirds.In our study,generalized linear models and structural equation modeling showed that Chinese Blackbirds tended to initiate laying earlier and lay eggs with larger volume along an increasing urbanization gradient.We also found that urbanization did not affect the growth condition of nestlings,and the predation risk was lower in more urbanized habitats.Most importantly,urbanization did not have negative consequences on the reproductive success of Chinese Blackbirds.Our results show changes in the breeding behavior of Chinese Blackbirds as they adapt to rapid urbanization and suggest that certain more urbanized areas may be suitable for the breeding of bird populations. 展开更多
关键词 Breeding performance Predation Reproductive success Urbanization
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Reproductive function and sperm parameters in men with sickle cell disease:a systematic review 认领 引用
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作者 Clarisse Leblanc Nathalie Sermondade +10 位作者 Ludmilla Ogouma-Aworet Anna Ly Diane Rivet-Danon Guillaume Bachelot François Lionnet Aline Santin Anne-Gaël Cordier Kamila Kolanska Rachel Lévy Isabelle Berthaut Charlotte Dupont 《Asian Journal of Andrology》 SCIE CAS CSCD 2026年第2期117-127,共11页
Sickle cell disease(SCD)is one of the most common hereditary diseases in the world.It leads to hemolytic anemia and painful vaso-occlusive crises that can damage target organs at the cardiopulmonary,cerebrovascular,an... Sickle cell disease(SCD)is one of the most common hereditary diseases in the world.It leads to hemolytic anemia and painful vaso-occlusive crises that can damage target organs at the cardiopulmonary,cerebrovascular,and renal levels.SCD has also significant consequences on reproductive functions and fertility.Moreover,the treatments designed to alleviate and reduce vaso-occlusive crises directly impact male reproductive functions.Nevertheless,literature assessing the impact of SCD and its treatments on male reproductive functions remains limited and lacks robust evidence.A systematic review of the literature following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)recommendation was carried out on the reproductive functions of men with SCD and the reproductive options available to them.Most studies have found that men with SCD frequently exhibit impaired sperm parameters.In addition,hydroxyurea(HU),proposed to relieve and reduce vaso-occlusive crises,is also known to impact male reproductive functions,and the reversibility of these consequences on sperm parameters remains hypothetical.Hematopoietic stem cell transplantation(HSCT)is currently the only curative treatment.However,conditioning treatments are highly gonadotoxic and can permanently alter spermatogenesis.Young men with SCD should therefore be informed about fertility at an early stage,and fertility preservation should be discussed in pubescent men,especially if treatment with HU or HSCT is to be initiated.In prepubertal boys about to undergo HSCT,immature testicular tissue freezing should be discussed,even though this technique is still experimental. 展开更多
关键词 fertility preservation hydroxyurea male reproductive functions sickle cell disease sperm parameters
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MEI4 variations drive female reproductive disorders via impaired oocyte abundance and developmental potential 认领 引用
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作者 Yiyang Wang Yu Qi +16 位作者 Keyan Xu Shuyan Tang Luyi Tan Bingying Xu Ying Wang Shuxian Zhang Yang Zou Yuan Gao Chunmei Zhang Xin Liang Xue Jiao Shidou Zhao Han Zhao Shixuan Wang Yingying Qin Ting Guo Zi-Jiang Chen 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2026年第4期615-629,共15页
Meiotic DNA double-strand break(DSB)formation is pivotal for oocyte development,regulating both ovarian reserve and oocyte developmental potential.Mutations in DSB formation genes have been associated with premature o... Meiotic DNA double-strand break(DSB)formation is pivotal for oocyte development,regulating both ovarian reserve and oocyte developmental potential.Mutations in DSB formation genes have been associated with premature ovarian insufficiency(POI)and adverse pregnancy outcomes in women.Whole exome sequencing in 1530 POI patients across two Chinese cohorts identifies loss-of-function variants in the DSB formation gene,MEI4,enriched in POI.These MEI4 variants impair DSB formation in vitro and reveal a previously unrecognized function of the MEI4 C-terminus in stabilizing the MEI4-REC114 subcomplex on the chromosome axes.Additionally,Mei4Arg356*/Arg356*mice display severe defects in DSB formation,leading to massive apoptosis in oocytes triggered by the HORMAD1-dependent synapsis checkpoint in late prophase I.The few mutant oocytes surviving past the checkpoint exhibit low developmental potential,characterized by complete early embryonic arrest due to aneuploidy.Notably,heterozygous Mei4+/Arg356*mice show intermediate follicle depletion and embryonic development arrest consistent with the phenotype of heterozygous POI and preimplantation embryonic arrest,suggesting a haploinsufficiency effect.This study defines the impacts of MEI4 mutation on oocyte quantity and quality,which can guide genetic diagnosis and intervention in patients with POI and early embryonic arrest,especially those with mutations in meiotic DSB formation genes. 展开更多
关键词 Female reproductive disorders DNA double-strand break formation Meiosis Premature ovarian insufficiency MEI4 Preimplantation embryonic arrest
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Stone-like fruit is associated with reduced herbivory and enhanced reproductive success in an alpine legume(Phyllolobium heydei) 认领 引用
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作者 Feng Gao Quan Yuan +2 位作者 Hong-Sen Hua Hao-Ran Sun Yang Dong 《Plant Diversity》 SCIE CAS CSCD 2026年第4期851-854,共4页
Camouflagehas evolved independently across the tree of life as a defensive strategy to avoid predator attacks(Lev-Yadun et al.,2004;Niu et al.,2018).Although widespread in animals,camouflageis relatively rare in plant... Camouflagehas evolved independently across the tree of life as a defensive strategy to avoid predator attacks(Lev-Yadun et al.,2004;Niu et al.,2018).Although widespread in animals,camouflageis relatively rare in plants(Niu et al.,2018). 展开更多
关键词 Fruits Camouflage Adaptive evolution Phyllolobium heydei Anti-predator defenses Reproductive success
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Effects of metformin and glutathione alone and in coformulation with other compounds on reproductive health and fertility in diabetic male rodents: A systematic review 认领 引用
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作者 Razia Sardar Fatima Sardar +2 位作者 Nor-Ashikin Mohamed Noor Khan Fathiah Abdullah Yuhaniza Shafinie Kamsani 《Asian pacific Journal of Reproduction》 CAS 2026年第2期57-66,共10页
Objective:To systematically review the effects of administering metformin and glutathione alone and in coformulation with other compounds on the fertility and reproductive health of diabetic male rodents.Methods:The g... Objective:To systematically review the effects of administering metformin and glutathione alone and in coformulation with other compounds on the fertility and reproductive health of diabetic male rodents.Methods:The guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analyses(PRISMA)were followed to conduct this systematic review.Studies published until August 2024 in PubMed,Web of Science,and Scopus databases were searched,identified,screened,and selected for a detailed review.The keywords included metformin,diabetes,reproduction,glutathione,and rodent models.Results:A total of 166 studies were identified,of which 11 met the inclusion criteria and were included in the qualitative synthesis.One additional study was identified through snowballing and citation tracking,bringing the total to 12 studies.The findings indicate that metformin and glutathione,administered alone or in combination with other compounds,improved sperm count,motility,and morphology;restored reproductive hormone levels;reduced oxidative stress markers;and improved testicular histopathology in diabetic male rodents.Conclusions:Coformulation of metformin and glutathione with other compounds was found to be more effective in improving fertility and reproductive parameters in diabetic male rodents compared to mono-administration.However,further studies on the coformulation of metformin and glutathione are needed to confirm their efficacy and elucidate the underlying mechanisms.Study registration:The study protocol was registered in the International Prospective Register of Systematic Reviews(PROSPERO)with registration number CRD42024561820. 展开更多
关键词 Diabetes Met formin Glutathione Coformulation Reproductive health Infertility
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Evaluation of the protective effects of Crocus sativus L.against cypermethrin induced reproductive toxicity in male rats through the Nrf2 pathway and in silico ADMET analysis 认领 引用
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作者 Fareena Tariq Farah Ijaz +9 位作者 Yasameen Hameed Jasim Farah Naz Channa Sohail Ahmed Ahmed Shandookh Hameed Sobia Alyas Ahmed Raheem Rayshan Tahira Bibi Nazima Yousaf Khan Sadia Bibi Jameel Ahmed Buzdar 《Traditional Medicine Research》 2026年第3期12-25,共14页
Background:Epidemiological studies have confirmed that longer exposure to insecticides like cypermethrin(CYP)significantly increases the risk of male reproductive toxicity.Crocus sativus L.has been recognized due to i... Background:Epidemiological studies have confirmed that longer exposure to insecticides like cypermethrin(CYP)significantly increases the risk of male reproductive toxicity.Crocus sativus L.has been recognized due to its therapeutic properties,but its exact role and molecular mechanisms in treatment of reproductive dysfunction remain unclear.Methods:During this study,36 rats were randomly divided into six groups(n=6):control,CYP-induced(60 mg/kg),standard(leuprolide 3 mg/kg)and three treatment groups receiving aqueous,ethanolic,and oil extracts(50 mg/kg or 20 mL/kg)for post-toxicity induction.Results:The finding represented that exposure of CYP significantly increased oxidative stress,disrupted testicular architecture,and markedly reduced testosterone levels(P<0.05).Importantly,Crocus sativus L.treatment alleviated these changes by increasing the expression of Nrf2(nuclear factor erythroid 2-related factor 2),restoring the activity of antioxidant enzymes,and enhancing testicular histomorphology.Surprisingly,molecular docking established a high binding affinity of Crocus sativus L.phytoconstituents such as gallic acid,cinnamic acid and quercetin to the Nrf2-Keap1 complex.It is worth noting that,Crocus sativus L.exhibited a high level of protection against reproductive toxicity caused by CYP in male rats,which was mediated by the activation of Nrf2 pathway,reduction of oxidative damage,and favorable ADMET characteristics.Conclusion:Notably,this research provides a more valid,safe,and effective method of developing new drugs for reproductive disorders,however,further investigation is needed to support the research findings and implement it in clinical practice. 展开更多
关键词 Crocus sativus L. cypermethrin male reproductive toxicity Nrf2 pathway in silico ADMET analysis
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Multiomics integration identifies regulatory factors underlying reproductive disorders in geese 认领 引用
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作者 Qingyuan Ouyang Cong Lan +13 位作者 Shenqiang Hu Haizhou Gong Bincheng Tang Qingliang Chen Zhiyu He Junqi Wang Tanze Liu Shangmin Wang Xi Zhang Jiwei Hu Hua He Liang Li Hehe Liu Jiwen Wang 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2026年第7期2936-2949,共14页
Geese,descendants of migratory birds,have preserved the distinct reproductive and lipid metabolism traits of their wild ancestors.Therefore,compared to other poultry,geese have lower egg production ability and greater... Geese,descendants of migratory birds,have preserved the distinct reproductive and lipid metabolism traits of their wild ancestors.Therefore,compared to other poultry,geese have lower egg production ability and greater susceptibility to fatty liver.Recent research underscores the impact of lipid metabolism disorders on female reproductive health.In this context,we observed reproductive disorders(RD)and lipid metabolism anomalies in certain geese populations.This study systematically elucidated the differences between RD and normal geese at various levels,including genomics,transcriptomics,bile acid metabolomics,and microbiomics,revealing the crucial role of microorganisms.Our study provides a thorough examination of the ovarian anatomical,histological,and transcriptomic profiles between normal and RD geese.Genomic analyses pinpoint mutations in genes associated with bile acid metabolism,highlighting their potential role in RD pathogenesis.The genomic discoveries are substantiated by precise bile acid assays and ileum transcriptome analyses,which expose a significant disruption in bile acid absorption,activation of FXR,and an increase in serum chenodeoxycholic acid(CDCA)concentrations within RD geese.Notably,16S rRNA sequencing uncovers significantly greater beta diversity in the ileum microbiota of RD geese than in the normal group.Both Wilcoxon rank sum test and LEfSe analyses highlighted a marked increase in Romboutsia abundance in RD geese.Experimental cultivation of microbiota with CDCA supplementation confirms the impact of CDCA on Romboutsia lituseburensis proliferation.Gavage experiments with R.lituseburensis elucidate its involvement in primary follicle reduction via immune-mediated pathways.Collectively,our multifaceted analysis unravels the intricate involvement of Romboutsia in goose RD,offering insights from genetic,physiological,and microbial dimensions.Our findings not only deepen understanding of the etiology of RD in geese but also suggest potential avenues for therapeutic interventions targeting bile acid metabolism and modulation of specific microbiota components. 展开更多
关键词 goose bile acid gut microbiota reproduction dysfunction
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Protective Effects of Melatonin on the Female Reproductive System 认领 引用
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作者 Ziqi Fan Minghui Hao +3 位作者 Tongtong Wei Chongran Liu Wanjing Wang Yihang Song 《Journal of Clinical and Nursing Research》 2026年第5期328-337,共10页
Melatonin(MT)is an indoleamine hormone secreted predominantly by the pineal gland and exhibits diverse biological activities,including antioxidant,anti-inflammatory,anti-apoptotic,immunomodulatory,and mitochondrial-pr... Melatonin(MT)is an indoleamine hormone secreted predominantly by the pineal gland and exhibits diverse biological activities,including antioxidant,anti-inflammatory,anti-apoptotic,immunomodulatory,and mitochondrial-protective effects.In recent years,increasing attention has been paid to the role of MT in the regulation of female reproductive function and in the prevention and treatment of disorders of the female reproductive system.Accumulating evidence indicates that MT is involved in follicular development,oocyte maturation,sex steroid secretion,embryonic development,and pregnancy maintenance by scavenging reactive oxygen species,improving mitochondrial function,and modulating the hypothalamic-pituitary-gonadal axis and related signaling pathways.This review summarizes the biological properties and principal mechanisms of action of MT,with a focus on recent advances in its roles in ovarian function preservation,maintenance of oocyte quality,improvement of embryonic development,and intervention in pregnancy-related disorders. 展开更多
关键词 Melatonin Female reproductive system Oxidative stress Follicular development Embryo quality Mitochondrial protection
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Editorial commentary on the special issue of reproductive medicine 认领 引用
19
《Journal of Biomedical Research》 CAS CSCD 2026年第4期345-346,共2页
This special issue comprises one review and seven original articles covering diverse topics in reproductive medicine,including the microbiota–metabolite axis in endometriosis,BDE47-induced ferroptosis in spermatocyte... This special issue comprises one review and seven original articles covering diverse topics in reproductive medicine,including the microbiota–metabolite axis in endometriosis,BDE47-induced ferroptosis in spermatocytes,human papillomavirus(HPV)and fertility outcomes in endometriosis,metabolomic biomarkers for azoospermia stratification,gene function validation in male reproduction,endometrial preparation protocols and the vaginal microbiota,bisphenol A(BPA)-induced developmental cardiotoxicity,and diagnostic criteria for gestational diabetes. 展开更多
关键词 azoospermia stratificationgene function validation metabolite axis endometriosis preparation protocols microbiota reproductive medicine endometriosismetabolomic biomarkers microbiota metabolite axis
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Infertility,social pressure,and mental health:An empirical study based on a reproductive sociology framework 认领 引用
20
作者 Su-Han Huang Hong-Ping Ji +3 位作者 Xiao-Han Tang Meng Li Si-Cong Jiang Mei Yin 《World Journal of Psychiatry》 SCIE 2026年第7期265-277,共13页
BACKGROUND Infertility affects a significant proportion of the global population,with profound implications for psychological well-being.Social mechanisms,including stigma and cultural expectations,play a critical rol... BACKGROUND Infertility affects a significant proportion of the global population,with profound implications for psychological well-being.Social mechanisms,including stigma and cultural expectations,play a critical role in shaping mental health outcomes,yet few studies have systematically examined these pathways within a reproductive sociology framework.AIM To investigate how infertility-related social pressure influences mental health outcomes and validate a comprehensive assessment tool for this purpose.METHODS In this cross-sectional study,1200 patients with infertility were enrolled from 2023 to 2024 at Harbin Medical University in China.The Infertility Social Pressure and Mental Health Scale was developed and validated through confirmatory factor analysis and reliability testing.Structural equation modeling was used to evaluate social pressure as a mediator between infertility characteristics and mental health outcomes,while subgroup analyses explored gender,duration,and sociodemographic moderators.RESULTS The Infertility Social Pressure and Mental Health Scale demonstrated excellent psychometric properties(Cronbach’s α=0.92,comparative fit index=0.94,root mean square error of approximation=0.06).Social pressure significantly mediated the relationship between infertility and psychological distress(β=0.42,P<0.001).Higher mean social pressure scores were found in women than men(3.78 vs 2.94,P<0.001).Longer infertility duration,rural residence,and lower education were associated with greater vulnerability.Among pressure domains,selfimposed pressure showed the strongest correlation with depression and anxiety(r=0.72,P<0.001).CONCLUSION Social pressure represents a critical pathway linking infertility and adverse mental health outcomes.To improve patient outcomes,culturally sensitive psychosocial interventions,early screening,and support strategies are required. 展开更多
关键词 Infertility Social pressure Mental health Reproductive sociology Psychological distress
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