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Effectiveness of Xuanbai Shengmai Decoction,a compound Chinese herbal medicine,on disease progress and viral RNA shedding in COVID-19 patients:A retrospective study of medical chart in China 认领 引用
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作者 Teng-wen Liu Shu-wen Zhang +15 位作者 Hui Jiang Si-wen Yang Yi-jia Guo Mao-yu Ding Xu-cheng Li Jia Xu Hai-tian Lu Hao-ran Ye Ya-hui Hu Rui Li Yi-ming Wei Mai-fen Song Shuo Wang Jun Zhang Quan-sheng Feng Xiao-long Xu 《Journal of Integrative Medicine》 SCIE CAS CSCD 2026年第1期115-124,共10页
Objective:To describe the clinical features and effectiveness of Xuanbai Shengmai Decoction(XB,a compound Chinese herbal medicine)on disease progression,clinical effect and viral RNA shedding in COVID-19 cases.Methods... Objective:To describe the clinical features and effectiveness of Xuanbai Shengmai Decoction(XB,a compound Chinese herbal medicine)on disease progression,clinical effect and viral RNA shedding in COVID-19 cases.Methods:We collected demographic and clinical information of 212 COVID-19 cases from December2022 to January 2023,and divided these cases into two groups based on whether XB was used or not.Survival curves in the two groups were estimated by the Kaplan-Meier method.A smoothing approximation of time-to-event distributions was created based on a log-rank test and a restricted mean survival time model,and the Gaussian density estimation method.In addition,the effect of XB treatment on survival time was assessed using a series of Cox proportional hazards models.Results:Of all 212 COVID-19 cases,there were respectively 63 and 149 cases reported in XB group and non-XB group.Of those,128(60.4%)were male,with median age of 75.00 years,and 72.6%had one or more underlying medical conditions.The most common symptoms on admission were cough(64.6%),fever(39.6%),wheezing(27.8%)and sputum(13.2%).In addition,the gender,age group distribution,smoking,and drinking between two groups were of no significant difference(P>0.05).However,the clinical characteristics and CT findings in XB group were more serious than those in non-XB group.Nevertheless,the hazard of death in XB group was lower than that in non-XB group,especially on severe cases.Treatment with XB significantly protected against adverse outcomes,shorten the time of viral RNA shedding.Moreover,interventional therapy of XB within 1–2 days after hospital admission is confirmed with particularly effectiveness.Conclusion:Treatment of XB is effective for COVID-19 cases,particularly in reducing the mortality rate of severe cases,suggesting that XB may be used as an alternative treatment of SARS-COV-2 infection. 展开更多
关键词 COVID-19 Severe case Traditional Chinese medicine Retrospective study Mortality RNA shedding
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Impact of ozonated water on perianal infectious diseases:A retrospective study 认领 引用
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作者 Pei-Zhen Xiao Wen-Bing Zou +4 位作者 Jia-Wen Xu Tian Wang Ping Wang Jiao-Jiao Ma Chun-Hua Zheng 《World Journal of Gastrointestinal Surgery》 SCIE 2026年第7期202-209,共8页
BACKGROUND Perianal abscess is an abscess caused by acute or chronic infection in the space surrounding the rectum and anal canal.If untreated or improperly managed,it may progress to a chronic infection and develop i... BACKGROUND Perianal abscess is an abscess caused by acute or chronic infection in the space surrounding the rectum and anal canal.If untreated or improperly managed,it may progress to a chronic infection and develop into an anal fistula,severely threatening patient health.AIM To investigate the therapeutic benefits of perianal infectious diseases by evaluating its bactericidal effects on pathogenic bacteria,its influence on tissue growth factor expression,and its macroscopic effects on tissue repair.METHODS Medical records of 65 patients with perianal abscess or anal fistula admitted to the Guihang Guiyang Hospital between January 2022 and May 2022 were retrospectively reviewed.The distribution of bacterial strains isolated from pus and secretion cultures collected pre-operatively and intra-operatively was analyzed,and the five most common pathogenic bacteria were identified.Ozonated water at varying concentrations was then applied to the cultured bacteria to evaluate bactericidal effects within the same exposure time and determine the minimum effective concentration(Cmin)capable of eliminating the major pathogenic bacteria associated with common perianal infectious diseases.Additionally,another patient cohort of 143 patients with perineal abscess or anal fistula treated between June 2022 and April 2024 was enrolled,including 79 patients in the observation group receiving ozone treatment and 64 patients in the control group receiving routine therapy.Both groups underwent surgical intervention.The control group additionally received routine anti-inflammatory therapy,sitz baths,and postoperative wound dressing changes.In addition to these treatments,the observation group received postoperative irrigation of the abscess cavity wound with ozonated water at concentration Cmin(100 mL,rinsed for 1 minute,once in the morning and once in the evening).After intervention,the expression levels of vascular endothelial growth factor,transforming growth factor-β,and platelet-derived growth factor in perianal wound tissue were assessed,and the wound healing outcomes were compared between groups.RESULTS Among the 65 patients,56 showed positive bacterial cultures from pyogenic fluids.The identified bacteria were categorized as follows:(1)Pathogenic bacteria:Escherichia coli(34/56),Klebsiella pneumoniae(11/56),Staphylococcus aureus(4/56),Enterococcus faecium(3/56),and Proteus mirabilis(2/56);and(2)Nonpathogenic bacteria:Miscellaneous bacteria,including normal skin flora(2/56).Under the same exposure time,ozonated water exerted stronger bactericidal effects with increasing concentration and achieved complete elimination of the above pathogenic bacteria within 1 minute at a Cmin of 2.5 mg/L.The observation group showed significantly higher expression levels of tissue growth factors than the controls after treatment(vascular endothelial growth factor:36.42±1.60 vs 25.85±1.18;transforming growth factor-β:15.81±2.04 vs 10.63±0.80;platelet-derived growth factor:33.32±1.48 vs 24.75±1.75;P<0.001).At one week after treatment,the observation group also demonstrated significantly reduced wound secretion(0.92±0.47 vs 1.27±0.54;P<0.001),tissue edema(0.54±0.50 vs 0.94±0.77;P<0.05),and postoperative pain(1.77±0.80 vs 2.94±1.10;P<0.001),along with significantly faster granulation tissue growth(0.67±0.65 vs 1.19±0.69;P<0.001)compared with the control group.CONCLUSION Ozonated water irrigation is an effective approach for managing infected wounds in patients with perianal abscess or anal fistula and demonstrates promising clinical application value. 展开更多
关键词 Perianal abscess Ozonated water Growth factor Wound healing Retrospective study
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Risk factors for pathological upgrading pre-and post-endoscopic resection of colorectal adenoma:A retrospective study 认领 引用
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作者 Xu-Lin Zheng Tao Chen +6 位作者 Yang Yu Neng Wang Biao Jiang Yao Yao Yun-Fei Zhao Xin-Xin Yu Chun-Lin Su 《World Journal of Translational Medicine》 2026年第2期79-86,共8页
BACKGROUND Colorectal adenoma(CRA)is a precancerous lesion of colorectal cancer.Pathological upgrading often occurs when comparing preoperative endoscopic biopsy results with postoperative pathological findings in cer... BACKGROUND Colorectal adenoma(CRA)is a precancerous lesion of colorectal cancer.Pathological upgrading often occurs when comparing preoperative endoscopic biopsy results with postoperative pathological findings in certain adenomas.AIM To investigate the risk factors associated with pathological upgrading after endoscopic resection of CRAs.METHODS This retrospective study collected 200 cases of CRAs between January 2023 and December 2025.All adenomas underwent complete endoscopic resection and were divided into pathological upgrading and non-upgrading groups according to postoperative pathological findings.Baseline clinical data and endoscopic features of the adenomas were compared between the two groups to identify factors correlated with pathological upgrading.RESULTS Pathological upgrading was observed in 49 of the 200 included CRAs.No statistically significant differences were found between the two groups in age,gender,body mass index,smoking history,drinking history,diabetes history,personal tumor history,fasting blood glucose level,total cholesterol level,triglyceride level,platelet count,carcinoembryonic antigen level,and adenoma location.Significant intergroup differences were observed in hemoglobin level,adenoma diameter,Yamada classification,and mucosal hyperemia.Multivariate logistic regression analysis demonstrated that pathological upgrading incidence was significantly higher in adenomas with a diameter>20 mm than in those≤20 mm(odds ratio=23.237,95%CI:5.868-92.018,P20 mm are more susceptible to pathological upgrading and carry an elevated risk of undetected high-grade dysplasia or early carcinoma missed by preoperative biopsy. 展开更多
关键词 Colorectal adenoma Colorectal cancer Pathological upgrading Endoscopic resection Risk factor Retrospective study
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Comprehensive geriatric assessment guiding treatment and survival in elderly digestive tumor patients:A retrospective study 认领 引用
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作者 Lei Zhu Xiao-Feng Liu 《World Journal of Gastrointestinal Oncology》 SCIE 2026年第5期174-182,共9页
BACKGROUND The intensification of global aging has led to an increasing burden of digestive system tumors in the elderly.The comprehensive geriatric assessment(CGA)provides important basis for developing individualize... BACKGROUND The intensification of global aging has led to an increasing burden of digestive system tumors in the elderly.The comprehensive geriatric assessment(CGA)provides important basis for developing individualized treatment plans by systematically assessing factors such as patient function,nutrition,and comorbidities.AIM To examine the value of the CGA in treatment decision-making and survival prognosis among elderly patients with digestive system tumors.METHODS This retrospective study analyzed the clinical data of 210 elderly patients with digestive system tumors admitted between April 2022 and July 2025.Of these,108 patients who received traditional diagnostic and therapeutic decisions(April 2022 to December 2023)constituted the control group,whereas 102 patients who received CGA-guided diagnostic and therapeutic decisions(January 2024 to July 2025)comprised the observation group.The initial treatment strategy,intensity,safety,and tolerance,as well as progression-free survival(PFS),were compared between the two groups.RESULTS Fewer patients in the observation group received standard treatment and standard-intensity chemotherapy compared with the control group,whereas more received reduced-intensity chemotherapy.The overall incidence of adverse reactions(≥grade 3)was 28.4%in the observation group,compared with 45.4%in the control group.Treatment delay and discontinuation rates were lower in the observation group(20.6% and 11.8%,respectively)than in the control group(32.4%and 24.1%,respectively).The treatment completion rate was higher in the observation group(88.2%)than in the control group(75.9%).The median PFS was longer in the observation group(11.5 months,95% confidence interval:10.2-12.8)than in the control group(9.1 months,95% confidence interval:8.0-10.2).All differences were statistically significant(P<0.05).Multivariate Cox regression analysis showed that a CGAassessed“frail”status was an independent risk factor affecting patient PFS(P<0.05).CONCLUSION CGA-guided diagnostic and therapeutic strategies facilitate precise,individualized decision-making for elderly patients with digestive system tumors.By tailoring treatment selection and intensity to overall health status,this approach optimizes the balance between efficacy and safety and is associated with improved PFS,supporting its clinical utility. 展开更多
关键词 Comprehensive geriatric assessment Digestive system neoplasms Treatment decision-making Survival prognosis Retrospective studies
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Helicobacter pylori positively associated with colorectal cancer and advanced, but not low-risk, adenomas: A retrospective study in China 认领 引用
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作者 Na Shan Jun-Jie Hou +3 位作者 Chao-Qiong Jin Qi Jin Yue-Hua Qin Wei-Wei Li 《World Journal of Gastrointestinal Surgery》 SCIE 2026年第4期184-194,共11页
BACKGROUND In addition to gastric cancer,emerging evidence indicate that individuals treated for Helicobacter pylori(H.pylori)infection experience a significant reduction in both colorectal cancer(CRC)proportion and m... BACKGROUND In addition to gastric cancer,emerging evidence indicate that individuals treated for Helicobacter pylori(H.pylori)infection experience a significant reduction in both colorectal cancer(CRC)proportion and mortality,suggesting a potential causative role of this infection in CRC.However,in the Chinese population,it remains unclear whether H.pylori infection is involved in the early stages of colorectal carcinogenesis or is associated with the risk of colorectal polyps(CPs).Therefore,we conducted a retrospective study based on 5986 gastroscopy and colonoscopy patients without a treatment history of H.pylori in Zhejiang Province(China).AIM To investigate H.pylori’s association with CRC and the different types of CPs,and its potential to alter their risks.METHODS A retrospective cross-sectional study was performed with 5986 patients who had undergone gastroscopy and colonoscopy.Pearsonχ2 test was used for analyzing how H.pylori are correlated to various CPs and CRC.H.pylori as a risk factor for various CPs and CRC was determined by multivariable logistic regression.RESULTS H.pylori-positive patients demonstrated a significantly higher proportion of advanced adenomas(AAs)than negative patients(7.51%vs 5.61%;P=0.006),with a non-significant increase in CRC proportion(1.45%vs 1.15%).No significant differences were observed for non-adenomatous polyps or low-risk adenomas,and infection levels showed no association with CRC or CPs proportion.H.pylori infection was linked to a more distal CRC location(P<0.05)but not to AAs characteristics.Furthermore,the analysis showed an association between H.pylori infection and increased odds of AAs(odds ratio=1.53,95%confidence interval:1.20-1.93)and RC(odds ratio=1.70,95%confidence interval:1.01-2.80).CONCLUSION In a similar clinical population of Chinese,H.pylori infection may be a risk factor for both AAs and CRC but not non-adenomatous polyps or low-risk adenomas.This suggests that H.pylori-positive patients should prioritize colonoscopy. 展开更多
关键词 Helicobacter pylori Colorectal advanced adenomas Colorectal cancer Retrospective cross-sectional study Multivariable logistic regression analysis Core Tip:In the Chinese population,it remains
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Factors influencing postoperative complications in patients with gastric cancer:A retrospective study 认领 引用 被引量：5
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作者 Ying Xiao Bang-Chun Ren +2 位作者 Tao Zhang Dong Peng Jiang Min 《World Journal of Gastrointestinal Surgery》 SCIE 2025年第5期117-125,共9页
BACKGROUND Gastric cancer is a malignancy with high morbidity and mortality rates.Surgical intervention,particularly gastrectomy,is essential for curative treatment but carries a substantial risk of complications.Iden... BACKGROUND Gastric cancer is a malignancy with high morbidity and mortality rates.Surgical intervention,particularly gastrectomy,is essential for curative treatment but carries a substantial risk of complications.Identifying key risk factors and understanding complication profiles are crucial for improving outcomes and guiding perioperative management.AIM To analyze the incidence of postoperative complications in patients with gastric cancer and identify potential risk factors.METHODS We conducted a retrospective analysis of 500 patients who underwent gastrectomy between January 2018 and December 2022.Postoperative complications were classified using the Clavien-Dindo system.RESULTS The overall complication rate was 28.4%(142/500),with 15.2%(76/500)experiencing major complications(Clavien-Dindo grade≥III).Pulmonary complications were the most frequent(10.8%),followed by surgical site infections(8.6%),and anastomotic leakage(4.2%).Age 70 years or more,body mass index of 25 kg/m²or more,advanced tumor stage,total gastrectomy,and operative time 240 min or more emerged as independent risk factors.CONCLUSION Focused preoperative risk assessment,targeted interventions,and reduced operative time for older or obese patients requiring total gastrectomy or presenting with advanced disease are important to improve surgical outcomes. 展开更多
关键词 Gastric cancer Postoperative complications Risk factors Gastrectomy Retrospective study
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Epidemiology and risk of pulmonary complications following hepatobiliary surgical procedures:A retrospective study 认领 引用
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作者 Hui-Jie Meng Zhong-Hao Chen +4 位作者 Guang-Meng Nie Zhao-Shuai Ji Yu-Jie Wang Yong-Fang Hu Jing Tang 《World Journal of Gastrointestinal Surgery》 SCIE 2025年第9期251-261,共11页
BACKGROUND Postoperative pulmonary complications(PPCs)are the most common complications following major upper abdominal surgeries,particularly hepatobiliary procedures,and significantly compromise surgical outcomes an... BACKGROUND Postoperative pulmonary complications(PPCs)are the most common complications following major upper abdominal surgeries,particularly hepatobiliary procedures,and significantly compromise surgical outcomes and patients’quality of life.Although the adoption of laparoscopy has lowered their incidence,PPCs remain a frequent and serious concern after hepatobiliary surgery.Existing research on risk factors specific to hepatobiliary surgeries is limited,particularly regarding the epidemiology and risk factors of PPCs in liver and gallbladder surgeries in China.Therefore,this study aimed to investigate the risk factors for PPCs in a large hepatobiliary center.AIM To identify the incidence and risk factors for PPCs following hepatobiliary surgery based on perioperative variables.METHODS Retrospective data were collected from patients who underwent liver,gallbladder,or pancreatic surgery at a hepatobiliary center in China between May 2023 and December 2023.We retrospectively reviewed comprehensive medical records to extract demographic and hospital admission information for determining PPC incidence.Statistically significant variables were initially screened through univariate analysis,followed by binary logistic regression modeling to identify independent predictors of PPCs.Hospitalization expenditures and duration of stay were further contrasted across the study cohorts.RESULTS This study included 1941 patients who underwent liver,gallbladder,or pancreatic surgery,of whom 78 developed PPCs,resulting in an incidence rate of 4.02%.Logistic regression analysis revealed two independent predictors of PPCs in hepatobiliary surgery patients:Age≥75 year(odds ratio=8.350,95%CI:3.521-19.798,P<0.001)and prolonged anesthesia(odds ratio=1.052,95%CI:1.015-1.091,P=0.006).Patients with PPCs had significantly elevated healthcare resource utilization,including higher total hospitalization costs,increased medication expenses,longer hospital stays,and extended postoperative admissions(all P<0.001).CONCLUSION Age≥75 years and prolonged anesthesia emerged as independent predictors of PPCs following hepatobiliary surgery.These complications were correlated with protracted hospitalization and increased healthcare costs. 展开更多
关键词 Postoperative pulmonary complications Hepatobiliary surgical procedures Risk factors Retrospective study Epidemiology
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Metastatic lymph node distribution and pathology correlations in upper and lower gastric cancer patients:A multicenter retrospective study 认领 引用 被引量：2
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作者 Xian-Bei Yuan Gang Sun +3 位作者 Jun Niu Lei Dong Yi Sui Yong-Zhu Lv 《World Journal of Gastrointestinal Oncology》 SCIE 2025年第2期56-66,共11页
BACKGROUND Gastric cancer(GC)poses a significant threat to public health.However,the clinicopathological features and tumor biological behaviors vary among the GC patients,leading to individual variations in lymph nod... BACKGROUND Gastric cancer(GC)poses a significant threat to public health.However,the clinicopathological features and tumor biological behaviors vary among the GC patients,leading to individual variations in lymph node metastasis.Consequently,the stratification of lymph node dissection according to the specific type,particularly upper GC,has emerged as a prominent area of research.AIM To investigate the distribution of metastatic lymph nodes in patients with upper and lower GC and to analyze the differences in related pathological elements and prognosis.METHODS Differential analysis between upper and lower GC patients with various clinicopathological factors was performed using the chi-square test and rank-sum regression models were used to analyze risk factors affecting patient prognosis.The Kaplan-Meier method was used to construct survival curves associated with prognostic risk factors for GC.RESULTS Significant differences were observed between the two GC populations regarding tumor diameter,histological grade,pT stage,pN stage,tumor-node-metastasis(pTNM)stage,vascular invasion,and adjuvant chemotherapy usage(all P<0.05).Lymph node metastasis rates were highest for Siewert type II patients in groups Nos.1,3,2 and 7;for Siewert type III patients in groups Nos.3,1,2 and 7;and for other/unclassified patients in groups Nos.1,3,7,2.In the lower GC samples,the sequences were Nos.3,6,7,4.Pathological type,pT stage,pTNM stage,and positive vascular invasion were independent risk factors for development of lymph node metastasis.Age,pathological type,pT stage,pN stage,pTNM stage,vascular invasion,and absence of adjuvant chemotherapy were identified as independent prognostic factors.CONCLUSION Upper GC showed a significantly higher malignancy grade and different lymph node metastasis pattern than lower GC. 展开更多
关键词 Upper gastric cancer Lower gastric cancer Metastatic lymph nodes Prognosis Retrospective study
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Development and Validation of a Nomogram Prediction Model for Sepsis-Induced Coagulopathy:A Multicenter Retrospective Study 认领 引用
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作者 Wen-hao Ma Ze-yu Yang +8 位作者 Xing-xing Fan Lei Tian Tuo Zhang Ming-da Wang Ji-yuan Gao Jian-le Xu Wei Fang Hui-min Hou Man Chen 《Current Medical Science》 SCIE CAS CSCD 2025年第4期867-876,共10页
Objective This study aimed to develop a prediction model to assess the risk of sepsis-induced coagulopathy(SIC)in sepsis patients.Methods We conducted a retrospective study of septic patients admitted to the Intensive... Objective This study aimed to develop a prediction model to assess the risk of sepsis-induced coagulopathy(SIC)in sepsis patients.Methods We conducted a retrospective study of septic patients admitted to the Intensive Care Units of Shandong Provincial Hospital(Central Campus and East Campus),and Shenxian People’s Hospital from January 2019 to September 2024.We used Kaplan-Meier analysis to assess survival outcomes.LASSO regression identified predictive variables,and logistic regression was employed to analyze risk factors for pre-SIC.A nomogram prediction model was developed via R software and evaluated via receiver operating characteristic(ROC)curves,calibration curves,and decision curve analysis(DCA).Results Among 309 patients,236 were in the training set,and 73 were in the test set.The pre-SIC group had higher mortality(44.8%vs.21.3%)and disseminated intravascular coagulation(DIC)incidence(56.3%vs.29.1%)than the non-SIC group.LASSO regression identified lactate,coagulation index,creatinine,and SIC scores as predictors of pre-SIC.The nomogram model demonstrated good calibration,with an AUC of 0.766 in the development cohort and 0.776 in the validation cohort.DCA confirmed the model’s clinical utility.Conclusion SIC is associated with increased mortality,with pre-SIC further increasing the risk of death.The nomogram-based prediction model provides a reliable tool for early SIC identification,potentially improving sepsis management and outcomes. 展开更多
关键词 Sepsis Sepsis-induced coagulopathy Thromboelastography Prediction model Nomogram Early diagnosis Intensive care unit(ICU) Retrospective study
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Multi-Phase Contrast-Enhanced CT Clinical-Radiomics Model for Predicting Prognosis of Extrahepatic Cholangiocarcinoma After Surgery:A Single-Center Retrospective Study 认领 引用
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作者 Shen-Bo Zhang Zheng Wang +3 位作者 Ge Hu Si-Hang Cheng Zhi-Wei Wang Zheng-Yu Jin 《Chinese Medical Sciences Journal》 CAS CSCD 2025年第3期161-170,I0001,共10页
Objective To develop and validate a preoperative clinical-radiomics model for predicting overall survival(OS)and disease-free survival(DFS)in patients with extrahepatic cholangiocarcinoma(eCCA)undergoing radical resec... Objective To develop and validate a preoperative clinical-radiomics model for predicting overall survival(OS)and disease-free survival(DFS)in patients with extrahepatic cholangiocarcinoma(eCCA)undergoing radical resection.Methods In this retrospective study,consecutive patients with pathologically-confirmed eCCA who underwent radical resection at our institution from 2015 to 2022 were included.The patients were divided into a training cohort and a validation cohort according to the chronological order of their CT examinations.Least absolute shrinkage and selection operator(LASSO)-Cox regression was employed to select predictive radiomic features and clinical variables.The selected features and variables were incorporated into a Cox regression model.Model performance for 1-year OS and DFS prediction was assessed using calibration curves,area under receiver operating characteristic curve(AUC),and concordance index(C-index).Results This study included 123 patients(mean age 64.0±8.4 years,85 males/38 females),with 86 in the training cohort and 37 in the validation cohort.The OS-predicting model included four clinical variables and four radiomic features.It achieved a training cohort AUC of 0.858(C-index=0.800)and a validation cohort AUC of 0.649(C-index=0.605).The DFS-predicting model included four clinical variables and four other radiomic features.It achieved a training cohort AUC of 0.830(C-index=0.760)and a validation cohort AUC of 0.717(C-index=0.616).Conclusion The preoperative clinical-radiomics models show promise as a tool for predicting 1-year OS and DFS in eCCA patients after radical surgery. 展开更多
关键词 extrahepatic cholangiocarcinoma radiomics prognosis retrospective study
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Traditional Chinese herbal medicine Qingre Xiaozheng formula(清热消癥方)improves renal outcomes in patients with diabetic kidneydisease:a retrospective study 认领 引用 被引量：1
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作者 SUN Weiwei ZHANG Jiale +6 位作者 YANG Hanwen YAN Runze WEI Shuwu WU Qiaoru CUI Zhaoli ZHENG Huijuan WANG Yaoxian 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2025年第4期873-880,共8页
OBJECTIVE:To assess the benefits of Qingre Xiaozheng formula(清热消癥方,QRXZF)as an adjunct to standard Western medical management on renal outcomes in patients with diabetic kidney disease(DKD).METHODS:This retrospec... OBJECTIVE:To assess the benefits of Qingre Xiaozheng formula(清热消癥方,QRXZF)as an adjunct to standard Western medical management on renal outcomes in patients with diabetic kidney disease(DKD).METHODS:This retrospective study included patients with DKD who received the QRXZF between May 2017 and May 2021.A total of 144 patients with DKD,24 h urinary total protein(24 h-UTP)≥0.5 g,and estimated glomerular filtration rate(e GFR)≥30 m L/min per 1.73 m2were divided into the treatment group or the control group based on whether they received QRXZF treatment.The long-term renal outcomes of patients with DKD were analyzed to evaluate the effectiveness of the QRXZF.Differences in overall survival(OS)were assessed using Kaplan-Meier curve analysis.Cox proportional hazards regression analysis was used to determine the independent risk factors for renal endpoints.RESULTS:The mean follow-up period was(28±15)months.Nine(12.5%)patients in the treatment group and 27(37.5%)patients in the control group met the renal endpoints.Multivariate Cox regression analysis showed that 24 h-UTP≥3.5 g[hazard ratio(HR)=4.70,95%confidence interval(CI)(1.83,12.05),P=0.001],combined coronary artery disease[HR=3.39,95%CI(1.65,6.98),P=0.001],total cholesterol[HR=1.34,95%CI(1.05,1.70),P=0.019]and low-density lipoprotein[HR=1.65,95%CI(1.111,2.45),P=0.013]were independent prognostic factors for renal endpoints in patients with DKD.Compared with the treatment group,the risk of renal endpoint events increased 2.68-fold in the control group[HR=2.68,95%CI(1.19,6.02);P=0.017].We included 48 patients with 24 h-UTP≥3.5 g in a further stratification analysis of patients with DKD.The independent risk factor for the renal endpoints in patients with 24h-UTP≥3.5 g was smoking history[HR=5.52,95%CI(1.131,26.92),P=0.035].Compared with the treatment group,the risk of renal endpoint events increased 3.01-fold in the control group[HR=3.01,95%CI(1.05,8.67);P=0.041].CONCLUSIONS:The results show that QRXZF treatment improved renal outcomes and reduced proteinuria in patients with DKD.These results indicate that Traditional Chinese Medicine is likely to have a positive therapeutic effect on established and advanced DKD.Further well-designed clinical trials with longer follow-up periods are required. 展开更多
关键词 diabetic nephropathies retrospective studies renal outcome Qingre Xiaozheng formula
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Effect of add-on therapy with Traditional Chinese Medicine on the survival of patients with anemic lower-risk myelodysplastic syndromes in the real-world setting:a retrospective study 认领 引用 被引量：1
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作者 QU Weiying TAN Xyucheng +2 位作者 ZHAO Yihan YU Yanan ZHAO Lin 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2025年第1期152-159,共8页
OBJECTIVE:To illustrate the effect of add-on therapy of Traditional Chinese Medicine(TCM)on the long-term survival of anemic lower-risk myelodysplastic syndromes(LR-MDS)patients.METHODS:In this study,we conducted a re... OBJECTIVE:To illustrate the effect of add-on therapy of Traditional Chinese Medicine(TCM)on the long-term survival of anemic lower-risk myelodysplastic syndromes(LR-MDS)patients.METHODS:In this study,we conducted a retrospective analysis of the data of patients with LR-MDS who were identified from Shuguang Hospital between January 2006 and June 2020.The Kaplan-Meier method was used to calculate overall survival(OS),while the Cox model was employed to analyze prognostic factors of long-term survival.A total of 162 patients who met the inclusion criteria were divided into two groups:the TCM group(n=78)or the non-TCM group(n=84).RESULTS:There were no significant differences in baseline characteristics.The cumulative survival rate of the TCM group was significantly higher than that of the non-TCM group[log-rank P=0.029,hazard ratio(HR)=0.484,95%confidence interval(CI)(0.249,0.942),P0.05).CONCLUSIONS:The integration of TCM and Western Medicine has the potential to extend the OS of LR-MDS patients when compared to the use of Western Medicine alone. 展开更多
关键词 lower-risk myelodysplastic syndromes medicine,Chinese traditional overall survival retrospective studies
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Incidental diagnosis of gallbladder carcinoma during or after routine cholecystectomy: A retrospective study with emphasis on clinicopathologic findings 认领 引用
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作者 Kasturi Saikia Zhengfan Xu +1 位作者 Nazila Azordegan Beena Umar Ahsan 《World Journal of Clinical Oncology》 2025年第7期199-206,共8页
BACKGROUND Cholecystectomy is a common surgical procedure routinely performed for patients with benign gallbladder disease.The most common indications for cholecystectomy are acute or chronic cholecystitis with or wit... BACKGROUND Cholecystectomy is a common surgical procedure routinely performed for patients with benign gallbladder disease.The most common indications for cholecystectomy are acute or chronic cholecystitis with or without cholelithiasis.However,in rare instances,incidental findings ranging from benign to malignant conditions are encountered,of which gallbladder adenocarcinoma is an aggre-ssive and fatal disease.AIM To determine the prevalence of all incidental diagnoses in routinely performed cholecystectomy specimens,with a particular emphasis on adenocarcinoma,and to characterize the clinicopathological characteristics of malignant postoperative specimens.METHODS The electronic medical record and institutional pathology database were searched for analyses done on gallbladder specimens from patients who had a routine cholecystectomy for benign gallbladder disease during the study period(February 2000 to February 2023).A total of 30678 cholecystectomies performed across the study period were included for analysis.Patients who had preoperative findings or radiological results concerning malignancy were excluded.The demographic and clinical data including patient age and gender,preoperative diagnosis,ra-diographic results at time of diagnosis,gross and morphologic features of gallbladder specimens,and pathologic staging parameters according to the American Joint Committee on Cancer were recorded.RESULTS Of the 30678 cholecystectomy specimens received by the Department of Pathology from patients with who had cholecystectomy for putative benign gallbladder disease during the study period,42(0.14%)were determined to be incidental gallbladder adenocarcinoma and 1 was adenocarcinoma in situ.There were 2 benign incidental dia-gnoses,including 9 patients(0.02%)with accessory/ectopic liver lobe,and 3 with paraganglioma.CONCLUSION Thorough histopathological examination of routine gallbladder specimens is important to provide an early diagnosis of unexpected gallbladder cancer to ensure that patients receive timely care when the disease is treatable. 展开更多
关键词 Incidental diagnosis Cholecystectomy Gallbladder adenocarcinoma Retrospective study
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Analysis of risk factors for post-operative infection following drugeluting trans arterial chemo embolization in hepatocellular carcinoma:A retrospective study 认领 引用 被引量：1
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作者 Gang Wang Rui Qi 《World Journal of Gastrointestinal Surgery》 SCIE 2025年第6期244-253,共10页
BACKGROUND Post-operative infection is a common and serious complication following drugeluting trans arterial chemo embolization(D-TACE)in patients with hepatocellular carcinoma(HCC),potentially compromising treatment... BACKGROUND Post-operative infection is a common and serious complication following drugeluting trans arterial chemo embolization(D-TACE)in patients with hepatocellular carcinoma(HCC),potentially compromising treatment efficacy and increasing morbidity.AIM To investigate the risk factors associated with post-operative infection in HCC patients undergoing D-TACE,and to provide evidence for clinical prevention and targeted intervention strategies.METHODS Clinical data of 77 primary HCC patients who underwent D-TACE in our hospital from January 2022 to December 2023 were retrospectively analyzed.Patient demographics,laboratory test results,tumor characteristics,and surgery-related parameters were collected.Univariate and multivariate logistic regression analyses were performed to identify risk factors for post-operative infection.RESULTS Post-operative infection occurred in 20 cases(25.97%)among the 77 patients.Univariate analysis showed that age≥65 years,Child-Pugh grade B,tumor diameter≥5 cm,operation time≥120 minutes,preoperative albumin<35 g/L,and comorbid diabetes were significantly associated with post-operative infection(P<0.05).Multivariate logistic regression analysis identified Child-Pugh grade B(OR=2.851,95%CI:1.426-5.698),operation time≥120 minutes(OR=2.367,95%CI:1.238-4.523),and preoperative albumin<35 g/L(OR=2.156,95%CI:1.147-4.052)as independent risk factors for post-operative infection.CONCLUSION Liver function status,operation time,and preoperative albumin level are significant factors affecting post-operative infection in HCC patients undergoing D-TACE.For high-risk patients,enhanced perioperative management,appropriate timing of surgery,and active improvement of nutritional status should be implemented to reduce the risk of post-operative infection. 展开更多
关键词 Hepatocellular carcinoma Drug-eluting trans arterial chemo embolization Post-operative infection Risk factors Retrospective study
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Incidence,risk factors and outcomes for post-hepatectomy portal vein thrombosis:A retrospective study 认领 引用
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作者 Jian-Ping Song Ming Xiao +4 位作者 Ji-Ming Ma Shang Zhang Liu-Qing Yang Zhi-Shuo Wang Can-Hong Xiang 《World Journal of Gastrointestinal Surgery》 SCIE 2025年第6期159-171,共13页
BACKGROUND Post-hepatectomy portal vein thrombosis(PH-PVT)is a life-threatening complication;however,the available literature on this topic is limited.AIM To examine the incidence,risk factors,and outcomes associated ... BACKGROUND Post-hepatectomy portal vein thrombosis(PH-PVT)is a life-threatening complication;however,the available literature on this topic is limited.AIM To examine the incidence,risk factors,and outcomes associated with PH-PVT.METHODS Medical records of patients who underwent hepatic resection for various diseases between February 2014 and December 2023 at Beijing Tsinghua Changgung Hospital affiliated with Tsinghua University(Beijing,China)were retrospectively reviewed.The patients were divided into a PH-PVT group and a non-PH-PVT group.Univariate and multivariate logistic regression analyses were performed to identify the risk factors for PH-PVT.RESULTS A total of 1064 patients were included in the study cohort,and the incidence and mortality rates of PH-PVT were 3.9%and 35.7%,respectively.The median time from hepatectomy to the diagnosis of PH-PVT was 6 days.Multivariate analysis revealed that hepatectomy combined with pancreaticoduodenectomy(HPD)[odds ratio(OR)=7.627(1.390-41.842),P=0.019],portal vein reconstruction[OR=6.119(2.636-14.203),P<0.001]and a postoperative portal vein angle<100°[OR=2.457(1.131-5.348),P=0.023]were independent risk factors for PH-PVT.Age≥60 years[OR=8.688(1.774-42.539),P=0.008]and portal vein reconstruction[OR=6.182(1.246-30.687),P=0.026]were independent risk factors for mortality in PH-PVT patients.CONCLUSION Portal vein reconstruction,a postoperative portal vein angle<100°and HPD were independent risk factors for PHPVT.Age≥60 years and portal vein reconstruction were independent risk factors for mortality in PH-PVT patients. 展开更多
关键词 Hepatectomy Portal vein thrombosis Incidence Risk factors Outcome Retrospective study
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Mindfulness-based stress reduction for sexual psychological recovery after radical cervical cancer surgery:A retrospective study 认领 引用
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作者 Qin-Qin Sun Fei-Fei Ke +3 位作者 Hong-You Zhou Shu-Jun Zhou Jin Lu Meng Gao 《World Journal of Psychiatry》 SCIE 2025年第12期263-275,共13页
BACKGROUND Patients who undergo radical cervical cancer surgery often experience sexual dysfunction and psychological distress,which seriously affects their quality of life.This study aimed to evaluate the clinical ef... BACKGROUND Patients who undergo radical cervical cancer surgery often experience sexual dysfunction and psychological distress,which seriously affects their quality of life.This study aimed to evaluate the clinical effectiveness of mindfulness-based stress reduction(MBSR)therapy for psychosexual adaptation in patients after radical cervical cancer surgery.AIM To systematically evaluate the clinical effectiveness of MBSR therapy on psychosexual adaptation in patients following radical cervical cancer surgery.METHODS A multicenter retrospective study design was used to analyze the clinical data of 280 patients who underwent radical cervical cancer surgery between January 2021 and August 2024 at Lishui Central Hospital,The Fifth Hospital Affiliated to Wenzhou Medical University,Lishui Hospital of Zhejiang University and Wenzhou Central Hospital.Patients were divided into an intervention group(n=140;receiving standard MBSR intervention)and a control group(n=140;receiving only routine care and sexual health guidance).Among these,140 cases were collected from Lishui Central Hospital,The Fifth Hospital Affiliated to Wenzhou Medical University,Lishui Hospital of Zhejiang University(70 in the intervention group and 70 in the control group)and Wenzhou Central Hospital(70 in the intervention group and 70 in the control group).RESULTS After intervention,patients in the MBSR intervention group showed significant improvement in anxiety and depression levels(anxiety:5.8±1.2 vs 8.3±1.7,P55 years;P=0.032).Multivariate regression analysis confirmed that MBSR intervention[odds ratios(OR)=2.86,95%confidence interval(95%CI):1.75-4.68,P<0.001]and partner support(OR=1.92,95%CI:1.28-2.87,P=0.002)were independent positive predictive factors for improving patients'psychosexual adaptation.CONCLUSION MBSR therapy can effectively improve anxiety and depression in patients after radical cervical cancer surgery and significantly enhance sexual function and sexual relationship satisfaction,with the effects being more pronounced in younger patients.This study demonstrated that MBSR,as an integrative intervention approach,has independent positive effects on psychosexual adaptation in post-operative cervical cancer patients and is worthy of promotion in clinical practice. 展开更多
关键词 Cervical cancer Radical surgery Mindfulness-based stress reduction therapy Psychosexual adaptation Anxiety and depression Sexual function Retrospective study therapy Sexual psychological adaptation Anxiety and depression
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Comparison of bronchoalveolar lavage recovery across patient positions:a retrospective study 认领 引用
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作者 Yiting Wang Xinglai Sun 《Science International Innovative Medicine》 2025年第1期37-42,共6页
Objective To compare the effect of patient positioning on bronchoscopy-guided bronchoalveolar lavage(BAL)recovery rate and to inform position selection in clinical practice.Methods A retrospective study was conducted ... Objective To compare the effect of patient positioning on bronchoscopy-guided bronchoalveolar lavage(BAL)recovery rate and to inform position selection in clinical practice.Methods A retrospective study was conducted using routine BAL records from 2019 to 2024 at a single center.Four position groups were analyzed(n=110 each):supine,lateral nondependent(target lung up),lateral dependent(target lung down),and prone.The primary outcome was recovery rate(%).Distributional assumptions were evaluated with the Shapiro-Wilk test and Levene's test.Group differences were assessed by one-way analysis of variance(ANOVA);pairwise post-hoc comparisons used Welch's t test with mean differences and 95%confidence intervals(CI).A linear regression model adjusted for lobar site was used to estimate lobe-adjusted marginal means by position.Results Mean(x±SD)recovery rates were:supine 52.08±7.70%,lateral nondependent 62.66±8.27%,lateral dependent 45.98±8.50%,prone 55.12±7.59%.Between-group differences were significant(ANOVA F=82.14,P<0.001).Lobe-adjusted marginal means were directionally consistent with unadjusted results.Conclusions Patient position is significantly associated with BAL recovery.When clinically feasible and safe,placing the target lung in the nondependent position yields higher recovery rates. 展开更多
关键词 bronchoscopy bronchoalveolar lavage patient positioning recovery rate retrospective study
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Epidemiological and clinical features,treatment status,and economic burden of traumatic spinal cord injury in China:a hospital-based retrospective study 认领 引用 被引量：21
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作者 Hengxing Zhou Yongfu Lou +32 位作者 Lingxiao Chen Yi Kang Lu Liu Zhiwei Cai David BAnderson Wei Wang Chi Zhang Jinghua Wang Guangzhi Ning Yanzheng Gao Baorong He Wenyuan Ding Yisheng Wang Wei Mei Yueming Song Yue Zhou Maosheng Xia Huan Wang Jie Zhao Guoyong Yin Tao Zhang Feng Jing Rusen Zhu Bin Meng Li Duan Zhongmin Zhang Desheng Wu Zhengdong Cai Lin Huang Zhanhai Yin Kainan Li Shibao Lu Shiqing Feng 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第5期1126-1132,共7页
Traumatic spinal cord injury is potentially catastrophic and can lead to permanent disability or even death.China has the largest population of patients with traumatic spinal cord injury.Previous studies of traumatic ... Traumatic spinal cord injury is potentially catastrophic and can lead to permanent disability or even death.China has the largest population of patients with traumatic spinal cord injury.Previous studies of traumatic spinal cord injury in China have mostly been regional in scope;national-level studies have been rare.To the best of our knowledge,no national-level study of treatment status and economic burden has been performed.This retrospective study aimed to examine the epidemiological and clinical features,treatment status,and economic burden of traumatic spinal cord injury in China at the national level.We included 13,465 traumatic spinal cord injury patients who were injured between January 2013 and December 2018 and treated in 30 hospitals in 11 provinces/municipalities representing all geographical divisions of China.Patient epidemiological and clinical features,treatment status,and total and daily costs were recorded.Trends in the percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department and cost of care were assessed by annual percentage change using the Joinpoint Regression Program.The percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department did not significantly change overall(annual percentage change,-0.5%and 2.1%,respectively).A total of 10,053(74.7%)patients underwent surgery.Only 2.8%of patients who underwent surgery did so within 24 hours of injury.A total of 2005(14.9%)patients were treated with high-dose(≥500 mg)methylprednisolone sodium succinate/methylprednisolone(MPSS/MP);615(4.6%)received it within 8 hours.The total cost for acute traumatic spinal cord injury decreased over the study period(-4.7%),while daily cost did not significantly change(1.0%increase).Our findings indicate that public health initiatives should aim at improving hospitals’ability to complete early surgery within 24 hours,which is associated with improved sensorimotor recovery,increasing the awareness rate of clinical guidelines related to high-dose MPSS/MP to reduce the use of the treatment with insufficient evidence. 展开更多
关键词 China clinical features costs epidemiology methylprednisolone sodium succinate methylprednisolone retrospective study traumatic spinal cord injury treatment
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Recanalization of extracranial internal carotid artery occlusion A 12-year retrospective study 认领 引用 被引量：22
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作者 Liqun Jiao Gang Song +4 位作者 Yang Hua Yan Ma Yanfei Chen Yabing Wang Feng Ling 《Neural Regeneration Research》 SCIE CAS CSCD 2013年第23期2204-2206,共3页
This study aimed to summarize therapy experience of carotid endarterectomy, carotid endarterec- tomy combined with Fogarty catheter embolectomy, and hybrid surgery for the treatment of extrac- ranial internal carotid ... This study aimed to summarize therapy experience of carotid endarterectomy, carotid endarterec- tomy combined with Fogarty catheter embolectomy, and hybrid surgery for the treatment of extrac- ranial internal carotid artery occlusion. The study included 65 patients with extracranial internal ca- rotid artery occlusion who underwent carotid endarterectomy, carotid endarterectomy combined with Fogarty catheter embotectomy, or hybrid surgery in the Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, China between January 2006 and December 2012. Prior to surgery, all patients underwent perfusion CT or xenon CT to evaluate the occlusion. The procedure for each patient was chosen according to digital subtraction angiography data. The carotid artery was successfully recanalized in 46 of 51 patients who underwent carotid endarterectomy, 9 of 10 patients who underwent carotid endarterectomy combined with Fogarty catheter embolectomy, and 3 of 4 patients who underwent hybrid surgery. In patients with symptomatic carotid artery occlusion, the carotid artery can be recanalized by choosing a treatment procedure based on imaging ex- amination findings. 展开更多
关键词 neural regeneration carotid occlusion carotid carotid artery stenting carotid endarterectorny recanalization retrospective study grants-supported paper neuroregeneration
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Association of obesity with Helicobacter pylori infection: A retrospective study 认领 引用 被引量：9
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作者 Mei-Yan Xu Lan Liu +2 位作者 Bao-Shi Yuan Jian Yin Qing-Bin Lu 《World Journal of Gastroenterology》 SCIE CAS 2017年第15期2750-2756,共7页
AIM To explore the association between Helicobacter pylori(H. pylori) infection and obesity/weight gain in a Chinese population.METHODS Our primary outcome was the change in body mass index(BMI). The generalized linea... AIM To explore the association between Helicobacter pylori(H. pylori) infection and obesity/weight gain in a Chinese population.METHODS Our primary outcome was the change in body mass index(BMI). The generalized linear models were used to explore the association between H. pylori infection and the change of BMI, and the logistic regression models were used to explore the association between H. pylori infection and obesity.RESULTS A total of 3039 subjects were recruited and analyzed, of which 12.8% were obese. The prevalence of H. pylori infection was 53.9%(1639/3039) overall and 54.6%(212/388) in the obese subjects. The change of BMI in the H. pylori(+) group was not significantly higher than that in the H. pylori(-) group after adjustment for potential confounding factors [RR = 0.988, 95%CI:0.924-1.057, P = 0.729]. The prevalence of obesity decreased 1.1% in the H. pylori(+) group and 0.5% in the H. pylori(-) group. The RR of H. pylori infection for obesity was 0.831(95%CI: 0.577-1.197, P = 0.321) after the adjustment.CONCLUSION H. pylori infection was not associated with overweight/obesity observed from the retrospective study in this Chinese population. 展开更多
关键词 Obesity Helicobacter pylori retrospective study China
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