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Antioxidant effects of selenium-glutathione peroxidase in inflammatory bowel diseases 认领 引用
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作者 Yuhui Fang Jinting Deng +5 位作者 Yanmei Zhang Shiyang Yue Chenxing Liu Lingyu Wang Caihua Liu Chenghua Wang 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第5期1976-1988,共13页
In recent years,the incidence of chronic inflammatory bowel disease(IBD)has been increasing,posing a serious threat to human health.Medication can lead to off-target,systemic side effects and serious complications,and... In recent years,the incidence of chronic inflammatory bowel disease(IBD)has been increasing,posing a serious threat to human health.Medication can lead to off-target,systemic side effects and serious complications,and safer treatments are urgently needed.Selenium(Se)supplementation can alleviate IBD by modulating gut flora and increasing antioxidant enzyme activities.Glutathione peroxidase(GPx)is a selenoprotein with good antioxidant capacity to eliminate inflammation and protect the intestinal.Herein,this paper comprehensively reviews the recent research progresses of Se-containing GPxs(GPx1-4)in alleviating IBD with oxidation stress as the main thread,summaries the underlying mechanisms of Se-containing GPx on the regulation of IBD.The different effects of inorganic Se,organic Se,and Se nanoparticles in the treatment of IBD are discussed. 展开更多
关键词 Selenium Glutathione peroxidase Inflammatory bowel disease Selenium-nanoparticles
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Chitosan-Selenate Complex Improves Bioactive Profile and Antioxidant Response in Wheat Sprouts (Triticum aestivum L.) 认领 引用
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作者 Jazmín Montserrat Gaucin-Delgado Cristian Oswaldo Solis-López +4 位作者 Pablo Preciado-Rangel Bernardo Espinosa-Palomeque Francisco Gerardo Veliz-Deras Viridiana Contreras-Villarreal Ricardo Israel Ramírez-Gottfried 《Phyton-International Journal of Experimental Botany》 SCIE 2025年第12期3961-3973,共13页
Selenium(Se)deficiency is a global health problem affecting more than 500 million people;crop biofortification is a sustainable strategy for its mitigation.This study investigated the effect of the application of sele... Selenium(Se)deficiency is a global health problem affecting more than 500 million people;crop biofortification is a sustainable strategy for its mitigation.This study investigated the effect of the application of selenate nanoparticles(SeO42−)and the combination of selenate(SeO42−)and chitosan(CS)(forming a SeO42−-CS complex)on the antioxidant profile,growth,biomass,bioactive compounds,enzymes,and Se accumulation of wheat(Triticum spp.)sprouts.Fourteen treatments were applied using a factorial design combining seven concentrations and two formulations:SeO42−and SeO42−-CS.It was identified that chitosan increased Se uptake efficiency by 30%versus conventional selenate.The optimal dose for biomass was 0.15 mg L−1 of SeO42−-CS(+40%vs.control),while 0.25 mg L−1 maximized bioactive compounds(phenolics(25%)and flavonoids(21%))as well as antioxidant capacity(26%)and enzymatic activity(SOD:37%;POD:41%).In addition,CS reduced Se phytotoxicity at doses≥1.50 mg L−1,evidencing its dual role as a delivery vehicle and cell protector.These findings demonstrate that the SeO42−-CS hybrid system is a technologically viable and efficient alternative to traditional selenate for the production of biofortified sprouts.This strategy shows high potential for scaling up in the functional food industry and for application in agricultural regions with selenium-deficient soils. 展开更多
关键词 Antioxidant response biofortification chitosan growth and biomass Se accumulation Selenium-nanoparticles
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