Most current design methods for geosynthetic-reinforced pile-supported(GRPS)embankments neglect the influence of fill cohesion,and are therefore only suitable for cohesionless fills.However,cohesive fills are also wid...Most current design methods for geosynthetic-reinforced pile-supported(GRPS)embankments neglect the influence of fill cohesion,and are therefore only suitable for cohesionless fills.However,cohesive fills are also widely used in GRPS embankments.To address this issue,we present an analytical model that expands the hemispherical arching model to incorporate cohesive fill properties.The proposed model integrates the soil arching effect,the tensioned membrane effect,and subsoil support to provide a simple approach for analyzing load transfer in GRPS embankments.To evaluate the effectiveness of the proposed model,a comparison with four well-known design methods is conducted using several case studies.This comparison demonstrates that the proposed model shows good agreement with the measured data,validating the reliability and applicability of our method.A parametric study is also performed,with the results indicating that the cohesion of fills enhances load transfer in GRPS embankments,resulting in a greater pile efficacy and a lower geosynthetic deflection.These findings provide valuable insights for the construction of GRPS embankments.展开更多
Interleukin-1 receptor-associated kinase 4(IRAK4),a key target with both enzymatic and non-enzymatic functions,plays a pivotal role in autoimmune diseases.Previous studies have demonstrated that proteolysis-targeting ...Interleukin-1 receptor-associated kinase 4(IRAK4),a key target with both enzymatic and non-enzymatic functions,plays a pivotal role in autoimmune diseases.Previous studies have demonstrated that proteolysis-targeting chimera(PROTAC)molecules targeting IRAK4 can effectively eliminate both its enzymatic and non-enzymatic functions,showing promising therapeutic potential.However,the development of highly potent,synthetically accessible IRAK4-targeting degraders remains a challenge.In this work,through three rounds of PROTAC library construction,screening,and optimization,we successfully identified a representative compound,LZ-07,which proved to be a highly potent degrader with a half-maximal degradation concentration(DC50)value of 1.14 nmol/L.Notably,compared with KT-474,LZ-07 demonstrated comparable degradation activity and superior inhibition of cytokine production,while featuring a simpler synthetic route with optimized IRAK4 and cereblon(CRBN)ligands.LZ-07-induced degradation of IRAK4 led to marked suppression of key cytokines,including interleukin-6(IL-6),IL-1β,tumor necrosis factor alpha(TNF-α),and IL-10.This study presents LZ-07 as a novel,highly efficient,and synthetically straightforward IRAK4-targeting degrader,offering a promising tool compound for the study of the potential treatment of autoimmune diseases.展开更多
This study proposes a multi-scale simplified residual convolutional neural network(MS-SRCNN)for the precise prediction of Mg-Nd binary alloy compositions from scanning electron microscope(SEM)images.A multi-scale data...This study proposes a multi-scale simplified residual convolutional neural network(MS-SRCNN)for the precise prediction of Mg-Nd binary alloy compositions from scanning electron microscope(SEM)images.A multi-scale data structure is established by spatially aligning and stacking SEM images at different magnifications.The MS-SRCNN significantly reduces computational runtime by over 90%compared to traditional architectures like ResNet50,VGG16,and VGG19,without compromising prediction accuracy.The model demonstrates more excellent predictive performance,achieving a>5%increase in R2 compared to single-scale models.Furthermore,the MS-SRCNN exhibits robust composition prediction capability across other Mg-based binary alloys,including Mg-La,Mg-Sn,Mg-Ce,Mg-Sm,Mg-Ag,and Mg-Y,thereby emphasizing its generalization and extrapolation potential.This research establishes a non-destructive,microstructure-informed composition analysis framework,reduces characterization time compared to traditional experiment methods and provides insights into the composition-microstructure relationship in diverse material systems.展开更多
As demand for lithium-ion batteries increases,the supply of materials is increasingly constrained by their geographical concentration.This has spurred significant research into recycling spent batteries to enhance res...As demand for lithium-ion batteries increases,the supply of materials is increasingly constrained by their geographical concentration.This has spurred significant research into recycling spent batteries to enhance resource circulation.Currently,commercially applied recycling methods(such as pyrometallurgy and hydrometallurgy)face environmental and economic challenges,including waste acid and gas generation,high-temperature heat treatment,and operational complexity.A promising alternative is the carbothermic reduction process,which operates at lower temperatures,minimizing costs and environmental emissions.However,this method still requires large quantities of external reducing agents.Therefore,this study aims to introduce a simplified direct carbothermic reduction(SDCR)process.The SDCR process leveraged carbon conductive materials and organic binders within the electrode as reducing agents.Additionally,the high compaction state created a conducive environment for reducing gases,promoting efficient reduction and material recovery.This approach reduces the reliance on external reducing agents and streamlines the re-upcycling process,making it commercially viable.展开更多
Acute myocardial infarction(AMI)is a leading cause of death and disability worldwide and consists of two distinct cardiac pathologies:ST-elevation myocardial infarction(STEMI)and non-ST-elevation myocardial infarction...Acute myocardial infarction(AMI)is a leading cause of death and disability worldwide and consists of two distinct cardiac pathologies:ST-elevation myocardial infarction(STEMI)and non-ST-elevation myocardial infarction(NSTEMI).[1]In China,AMI is widely recognized as a predominant cause of mortality in both urban and rural demographics,based on the 2022 Report on Cardiovascular Health and Diseases in China;moreover,its mortality rate has been reported to be rising,with a recurrence rate of 2.5%within one year.展开更多
Background: Early research describing the concept of intensity-modulated conformal radiotherapy (IMRT) was based on 7 to 9 beams to reach an adequate level of modulation. Nevertheless, its implementation demands signi...Background: Early research describing the concept of intensity-modulated conformal radiotherapy (IMRT) was based on 7 to 9 beams to reach an adequate level of modulation. Nevertheless, its implementation demands significant resources. Our objective was to compare the compliance and homogeneity of target dose distribution between simplified IMRT and 3D-CRT in patients with cervical cancer and to assess the clinical value of simplified IMRT. Materials and Methods: From 2016 to 2017, 17 patients with stage IIB - IIIC cervical cancer were treated with external beam radiotherapy using simplified IMRT (12 cases) or 3DCRT (05 cases) and brachytherapy. Prior to radiotherapy, CT scans were conducted to delineate the target volume. The clinical target volume (CTV) included the uterus, primary tumor, supravaginal portion of the cervix, paracervical tissue, common iliac, internal and external iliac lymph nodes, obturator, and pre sacral lymph nodes, and the surrounding tissues. If the lower vagina was involved, the target volume included the whole vagina. The planning target volume (PTV) included the CTV with 1 cm anteriorly and 0.5 cm in all other directions. The PTV received 95% of 45 Gy (1.8 Gy/25 fraction). Dose-volume histogram, conformity index, homogeneity index, and treatment time per fraction were compared. Results: The 3D-CRT plan was more homogeneous than the simplified IMRT plan, while the simplified IMRT plan was more conformal. The volume of small bowels that received high-dose radiation significantly increased with simplified IMRT compared to 3D-CRT. Treatment time per fraction was 6 and 13 minutes for 3D-CRT and simplified IMRT, respectively. Conclusion: The simplified IMRT treatment plan is technically and dosimetrically acceptable and an alternative to the classic 3D-CRT plan for cervical cancer. It provides better dose distribution than 3D-CRT. However, the 3D-CRT treatment plan significantly reduced the overall treatment time per fraction.展开更多
In order to study the differences in vertical component between onshore and offshore motions,the vertical-to-horizontal peak ground acceleration ratio(V/H PGA ratio) and vertical-to-horizontal response spectral ratio(...In order to study the differences in vertical component between onshore and offshore motions,the vertical-to-horizontal peak ground acceleration ratio(V/H PGA ratio) and vertical-to-horizontal response spectral ratio(V/H) were investigated using the ground motion recordings from the K-NET network and the seafloor earthquake measuring system(SEMS).The results indicate that the vertical component of offshore motions is lower than that of onshore motions.The V/H PGA ratio of acceleration time histories at offshore stations is about 50%of the ratio at onshore stations.The V/H for offshore ground motions is lower than that for onshore motions,especially for periods less than 0.8 s.Furthermore,based on the results in statistical analysis for offshore recordings in the K-NET,the simplified V/H design equations for offshore motions in minor and moderate earthquakes are proposed for seismic analysis of offshore structures.展开更多
AIM To simplify the diagnostic criteria for superficial esophageal squamous cell carcinoma(SESCC) on Narrow Band Imaging combined with magnifying endoscopy(NBI-ME).METHODS This study was based on the post-hoc analysis...AIM To simplify the diagnostic criteria for superficial esophageal squamous cell carcinoma(SESCC) on Narrow Band Imaging combined with magnifying endoscopy(NBI-ME).METHODS This study was based on the post-hoc analysis of a randomized controlled trial. We performed NBI-ME for 147 patients with present or a history of squamous cell carcinoma in the head and neck, or esophagus between January 2009 and June 2011. Two expert endoscopistsdetected 89 lesions that were suspicious for SESCC lesions, which had been prospectively evaluated for the following 6 NBI-ME findings in real time: "intervascular background coloration"; "proliferation of intrapapillary capillary loops(IPCL)"; and "dilation", "tortuosity", "change in caliber", and "various shapes(VS)" of IPCLs(i.e., Inoue's tetrad criteria). The histologic examination of specimens was defined as the gold standard for diagnosis. A stepwise logistic regression analysis was used to identify candidates for the simplified criteria from among the 6 NBI-ME findings for diagnosing SESCCs. We evaluated diagnostic performance of the simplified criteria compared with that of Inoue's criteria.RESULTS Fifty-four lesions(65%) were histologically diagnosed as SESCCs and the others as low-grade intraepithelial neoplasia or inflammation. In the univariate analysis, proliferation, tortuosity, change in caliber, and VS were significantly associated with SESCC(P < 0.01). The combination of VS and proliferation was statistically extracted from the 6 NBI-ME findings by using the stepwise logistic regression model. We defined the combination of VS and proliferation as simplified dyad criteria for SESCC. The areas under the curve of the simplified dyad criteria and Inoue's tetrad criteria were 0.70 and 0.73, respectively. No significant difference was shown between them. The sensitivity, specificity, and accuracy of diagnosis for SESCC were 77.8%, 57.1%, 69.7% and 51.9%, 80.0%, 62.9% for the simplified dyad criteria and Inoue's tetrad criteria, respectively.CONCLUSION The combination of proliferation and VS may serve as simplified criteria for the diagnosis of SESCC using NBIME.展开更多
Recently,the simplified spherical harmonics equations(SP)model has at tracted much att entionin modeling the light propagation in small tissue ggeometriesat visible and near-infrared wave-leng ths.In this paper,we rep...Recently,the simplified spherical harmonics equations(SP)model has at tracted much att entionin modeling the light propagation in small tissue ggeometriesat visible and near-infrared wave-leng ths.In this paper,we report an eficient numerical method for fluorescence moleeular tom-ography(FMT)that combines the advantage of SP model and adaptive hp finite elementmethod(hp-FEM).For purposes of comparison,hp-FEM and h-FEM are,respectively applied tothe reconstruction pro cess with diffusion approximation and SPs model.Simulation experiments on a 3D digital mouse atlas and physical experiments on a phantom are designed to evaluate thereconstruction methods in terms of the location and the reconstructed fluorescent yield.Theexperimental results demonstrate that hp-FEM with SPy model,yield more accurate results thanh-FEM with difusion approximation model does.The phantom experiments show the potentialand feasibility of the proposed approach in FMT applications.展开更多
Scale effect of ISWs loads on Floating Production Storage and Offloading(FPSO) is studied in this paper. The application conditions of KdV, eKdV and MCC ISWs theories are used in the numerical method. The depthaverage...Scale effect of ISWs loads on Floating Production Storage and Offloading(FPSO) is studied in this paper. The application conditions of KdV, eKdV and MCC ISWs theories are used in the numerical method. The depthaveraged velocities induced by ISWs are used for the velocity-inlet boundary. Three scale ratio numerical models λ=1, 20 and 300 were selected, which the scale ratio is the size ratio of numerical models to the experimental model.The comparisons between the numerical and former experimental results are performed to verify the feasibility of numerical method. The comparisons between the numerical and simplified theoretical results are performed to discuss the applicability of the simplified theoretical model summarized from the load experiments. Firstly, the numerical results of λ=1 numerical model showed a good agreement with former experimental and simplified theoretical results. It is feasible to simulate the ISWs loads on FPSO by the numerical method. Secondly, the comparisons between the results of three scale ratio numerical models and experimental results indicated that the scale ratios have more significant influence on the experimental horizontal forces than the vertical forces. The scale effect of horizontal forces mainly results from the different viscosity effects associated with the model’s dimension.Finally, through the comparisons between the numerical and simplified theoretical results for three scale ratio models, the simplified theoretical model of the pressure difference and friction forces exerted by ISWs on FPSO is applied for large-scale or full-scale FPSO.展开更多
Wind-tunnel tests of a large-scale sectional model with synchronous measurements of force and vibration responses were carried out to investigate the nonlinear behaviors of vertical vortex-induced forces (VIFs) on t...Wind-tunnel tests of a large-scale sectional model with synchronous measurements of force and vibration responses were carried out to investigate the nonlinear behaviors of vertical vortex-induced forces (VIFs) on three typical box decks (i.e., fully closed box, centrally slotted box, and semi-closed box). The mechanisms of the onset, development, and self-limiting phenomenon of the vertical vortex-induced vibration (VlV) were also explored by analyzing the energy evolution of different vertical VIF components and their contributions to the vertical VIV responses. The results show that the nonlinear components of the vertical VIF often differ from deck to deck; the most important components of the vertical VIF, governing the stable amplitudes of the vertical VIV responses, are the linear and cubic components of velocity contained in the self-excited aerodynamic damping forces. The former provides a constant negative damping ratio to the vibration system and is thus the essential power driving the development of the VIV amplitude, while the latter provides a positive damping ratio proportional to the square of the vibration velocity and is actually the inherent factor making the VIV amplitude self-limiting. On these bases, a universal simplified nonlinear mathematical model of the vertical VIF on box decks of bridges is presented and verified in this paper; it can be used to predict the stable amplitudes of the vertical VIV of long-span bridges with satisfactory accuracy.展开更多
We propose a simplified human regular mobility model to simulate an individual's daily travel with three sequential activities:commuting to workplace,going to do leisure activities and returning home.With the assu...We propose a simplified human regular mobility model to simulate an individual's daily travel with three sequential activities:commuting to workplace,going to do leisure activities and returning home.With the assumption that the individual has a constant travel speed and inferior limit of time at home and in work,we prove that the daily moving area of an individual is an ellipse,and finally obtain an exact solution of the gyration radius.The analytical solution captures the empirical observation well.展开更多
In this study, simplified numerical models are developed to analyze the soil-structure interaction (SSI) effect on frame structures equipped with viscoelastic dampers (VEDs) based on pile group foundation. First, ...In this study, simplified numerical models are developed to analyze the soil-structure interaction (SSI) effect on frame structures equipped with viscoelastic dampers (VEDs) based on pile group foundation. First, a single degree-of- freedom (SDOF) oscillator is successfully utilized to replace the SDOF energy dissipated structure considering the SSI effect. The equivalent period and damping ratio of the system are obtained through analogical analysis using the frequency transfer function with adoption of the modal strain energy (MSE) technique. Aparametric analysis is carried out to study the SSI effect on the performance of VEDs. Then the equilibrium equations of the multi degree-of-freedom (MDOF) structure with VEDs considering SSI effect are established in the frequency domain. Based on the assumption that the superstructure of the coupled system possesses the classical normal mode, the MDOF superstructure is decoupled to a set of individual SDOF systems resting on a rigid foundation with adoption of the MSE technique through formula derivation. Numerical results demonstrate that the proposed methods have the advantage of reducing computational cost, however, retaining the satisfactory accuracy. The numerical method proposed herein can provide a fast evaluation of the efficiency of VEDs considering the SSI effect.展开更多
In recent years, precast segmental concrete bridge columns became prevalent because of the benefits of accelerated construction, low environmental impact, high quality and low life cycle costs. The lack of a detailed ...In recent years, precast segmental concrete bridge columns became prevalent because of the benefits of accelerated construction, low environmental impact, high quality and low life cycle costs. The lack of a detailed configuration and appropriate design procedure to ensure a comparable performance with monolithic construction has impeded this structural system from being widely used in areas of high seismicity. In this study, precast segmental bridge column cyclic loading tests were conducted to investigate the performance of unbonded post-tensioned segmental bridge columns. One monolithic and two precast segmental columns were tested. The preeast segmental column exhibited minor damage and small residual displacement after the maximum 7% cyclic drift; energy dissipation (ED) can be enhanced byadding ED bars. The experimental results were modeled by a simplified pushover method (SPOM), as well as a fiber model (FIBM) finite element method. Forty-five cases of columns with different aspect ratios, axial load ratios and ED bar ratios were analyzed with the SPOM and FIBM, respectively. Using these parametric results, a simplified design method was suggested by regressive analysis. Satisfactory correlation was found between the experimental results and the simplified design method for preeast segmental columns with different design parameters.展开更多
A simplified two-dimensional(2-D)magneto-optical trap(MOT)for loading atoms into a 3-D MOT is realized.Instead of utilizing multiple wave plates and beam splitters to cover a large cooling region,we deploy cooling bea...A simplified two-dimensional(2-D)magneto-optical trap(MOT)for loading atoms into a 3-D MOT is realized.Instead of utilizing multiple wave plates and beam splitters to cover a large cooling region,we deploy cooling beams with elliptical cross-section profiles to achieve a comparable cooling volume.This simplification reduces the cost and difficulty of alignment.The 3-D MOT achieves a loading rate of 2×108 atoms per second via this simplified 2-D MOT.Correlation between the loading rate and parameters of optical system is also determined.展开更多
Evaporation erosion of the contacts is one of the fundamental failure mechanisms for relays. In this paper, the evaporation erosion characteristics are investigated for the copper contact pair breaking a resistive dir...Evaporation erosion of the contacts is one of the fundamental failure mechanisms for relays. In this paper, the evaporation erosion characteristics are investigated for the copper contact pair breaking a resistive direct current (dc) 30 V/10 A circuit in the air. Molten pool simulation of the contacts is coupled with the gas dynamics to calculate the evaporation rate. A simplified arc model is constructed to obtain the contact voltage and current variations with time for the prediction of the current density and the heat flux distributions flowing from the arc into the contacts. The evaporation rate and mass variations with time during the breaking process are presented. Experiments are carried out to verify the simulation results.展开更多
The aseismic design of cable-stayed bridges in the transverse direction with newly proposed metallic dampers that can accommodate both longitudinal and transverse movement of the deck has recently been considered.This...The aseismic design of cable-stayed bridges in the transverse direction with newly proposed metallic dampers that can accommodate both longitudinal and transverse movement of the deck has recently been considered.This work focuses on developing a simplified method to design an appropriate metallic damper.The seismic performance of cablestayed bridges with different damper stiffness,main span lengths,tower shapes and types of deck in the transverse direction are investigated.The transverse displacement of the deck of a cable-stayed bridge increases significantly with the increment of the damper stiffness,which proves that the design of the damper stiffness is crucial.A simplified model considering the damper stiffness,cable system and tower in the transverse direction is developed to evaluate the period and lateral displacement of a complicated cable-stayed bridge.Based on the simplified model,a design method is proposed and assessed using two cable-stayed bridges as examples.The results show that metallic dampers can be designed with high efficiency,and the optimal ductility of the damper can be selected.展开更多
Professionalism is crucial in all professions and is particularly important in the medical field.Measuring students' perceptions of professionalism can help to form education targeting the enhancement of professio...Professionalism is crucial in all professions and is particularly important in the medical field.Measuring students' perceptions of professionalism can help to form education targeting the enhancement of professionalism.This study aimed to validate an effective assessment tool for the measurement of medical students5 perceptions of medical professionalism in China's Mainland.The cross-sectional survey was conducted in three medical colleges in Guangdong,China.Of the 2103 eligible medical students,1976 responded,and 1856 questionnaires were deemed valid.Students from clinical medicine in these three medical colleges were randomly selected by cluster sampling.First,a Simplified Chinese Version questionnaire to measure Student's Perception of Medical Professionalism (SCV-SPMP) was constructed.Second,questionnaires from 1856 students majoring in clinical medicine at three medical colleges were included in the analysis.Third,exploratory factor analysis,Cronbach's alpha,item-subscale correlation,and confirmatory factor analysis were conducted to test the validity and reliability of the SCV-SPMP.Nine items were eliminated following exploratory factor analysis,and four subscales were extracted from the analysis.All internal consistency reliability exceeded the minimum standard.The overall Cronbach's alpha was 0.94,and four subscales' alphas were 0.82 (Accountability and excellence),0.81 (Duty),0.89 (Honor and integrity),and 0.85 (Practice habits and respect for others),respectively.The model fit was good.The convergent validity and discriminant validity were acceptable.The modified SCVSPMP was found to be a valid and reliable tool to capture the main features of Chinese students' perceptions of medical professionalism in four dimensions,and it provides a quantitative method for the measurement of the students' perceptions in China's Mainland..展开更多
Toppling failure of rock mass/soil slope is an important geological and environmental problem.Clarifying its failure mechanism under different conditions has great significance in engineering.The toppling failure of a...Toppling failure of rock mass/soil slope is an important geological and environmental problem.Clarifying its failure mechanism under different conditions has great significance in engineering.The toppling failure of a cutting slope occurred in a hydropower station in Kyushu,Japan illustrates that the joint characteristic played a significant role in the occurrence of rock slope tipping failure.Thus,in order to consider the mechanical properties of jointed rock mass and the influence of geometric conditions,a simplified analytical approach based on the limit equilibrium method for modeling the flexural toppling of cut rock slopes is proposed to consider the influence of the mechanical properties and geometry condition of jointed rock mass.The theoretical solution is compared with the numerical solution taking Kyushu Hydropower Station in Japan as one case,and it is found that the theoretical solution obtained by the simplified analysis method is consistent with the numerical analytical solution,thus verifying the accuracy of the simplified method.Meanwhile,the Goodman-Bray approach conventionally used in engineering practice is improved according to the analytical results.The results show that the allowable slope angle may be obtained by the improved Goodman-Bray approach considering the joint spacing,the joint frictional angle and the tensile strength of rock mass together.展开更多
A simple control structure in servo system is occasionally needed for simple industrial application which precise and high control performance is not exessively important so that the cost production can be reduced eff...A simple control structure in servo system is occasionally needed for simple industrial application which precise and high control performance is not exessively important so that the cost production can be reduced efficiently. Simplified vector control, which has simple control structure, is utilized as the permanent magnet synchronous motor control algorithm and genetic algorithm is used to tune three PI controllers used in simplified vector control. The control performance is obtained from simulation and investigated to verify the feasibility of the algorithm to be applied in the real application. Simulation results show that the speed and torque responses of the system in both continuous time and discrete time can achieve good performances. Furthermore, simplified vector control combined with genetic algorithm has a similar perfofmance with conventional field oriented control algorithm and possible to be realized into the real simple application in the future.展开更多
基金supported by the National Key Research and Development Program of China(No.2025YFE0107200)the National Natural Science Foundation of China(No.52378341).
摘要Most current design methods for geosynthetic-reinforced pile-supported(GRPS)embankments neglect the influence of fill cohesion,and are therefore only suitable for cohesionless fills.However,cohesive fills are also widely used in GRPS embankments.To address this issue,we present an analytical model that expands the hemispherical arching model to incorporate cohesive fill properties.The proposed model integrates the soil arching effect,the tensioned membrane effect,and subsoil support to provide a simple approach for analyzing load transfer in GRPS embankments.To evaluate the effectiveness of the proposed model,a comparison with four well-known design methods is conducted using several case studies.This comparison demonstrates that the proposed model shows good agreement with the measured data,validating the reliability and applicability of our method.A parametric study is also performed,with the results indicating that the cohesion of fills enhances load transfer in GRPS embankments,resulting in a greater pile efficacy and a lower geosynthetic deflection.These findings provide valuable insights for the construction of GRPS embankments.
基金supported by National Natural Science Foundation of China(Nos.82125034,82330115)National Key R&D Program of China(Nos.2021YFA1300200,2021YFA1302100)+1 种基金the Beijing Outstanding Young Scientist Program(No.JWZQ20240101007)Beijing Frontier Research Center for Biological Structure。
摘要Interleukin-1 receptor-associated kinase 4(IRAK4),a key target with both enzymatic and non-enzymatic functions,plays a pivotal role in autoimmune diseases.Previous studies have demonstrated that proteolysis-targeting chimera(PROTAC)molecules targeting IRAK4 can effectively eliminate both its enzymatic and non-enzymatic functions,showing promising therapeutic potential.However,the development of highly potent,synthetically accessible IRAK4-targeting degraders remains a challenge.In this work,through three rounds of PROTAC library construction,screening,and optimization,we successfully identified a representative compound,LZ-07,which proved to be a highly potent degrader with a half-maximal degradation concentration(DC50)value of 1.14 nmol/L.Notably,compared with KT-474,LZ-07 demonstrated comparable degradation activity and superior inhibition of cytokine production,while featuring a simpler synthetic route with optimized IRAK4 and cereblon(CRBN)ligands.LZ-07-induced degradation of IRAK4 led to marked suppression of key cytokines,including interleukin-6(IL-6),IL-1β,tumor necrosis factor alpha(TNF-α),and IL-10.This study presents LZ-07 as a novel,highly efficient,and synthetically straightforward IRAK4-targeting degrader,offering a promising tool compound for the study of the potential treatment of autoimmune diseases.
基金funded by the National Natural Science Foundation of China(No.52204407)the Natural Science Foundation of Jiangsu Province(No.BK20220595)the China Postdoctoral Science Foundation(No.2022M723689).
摘要This study proposes a multi-scale simplified residual convolutional neural network(MS-SRCNN)for the precise prediction of Mg-Nd binary alloy compositions from scanning electron microscope(SEM)images.A multi-scale data structure is established by spatially aligning and stacking SEM images at different magnifications.The MS-SRCNN significantly reduces computational runtime by over 90%compared to traditional architectures like ResNet50,VGG16,and VGG19,without compromising prediction accuracy.The model demonstrates more excellent predictive performance,achieving a>5%increase in R2 compared to single-scale models.Furthermore,the MS-SRCNN exhibits robust composition prediction capability across other Mg-based binary alloys,including Mg-La,Mg-Sn,Mg-Ce,Mg-Sm,Mg-Ag,and Mg-Y,thereby emphasizing its generalization and extrapolation potential.This research establishes a non-destructive,microstructure-informed composition analysis framework,reduces characterization time compared to traditional experiment methods and provides insights into the composition-microstructure relationship in diverse material systems.
基金supported by the National Research Foundation of Korea(NRF)grant funded by the Korea government(Ministry of Education).(No.2022R1A6A1A03051158,Research Center for Energy Conversion/Storage Utilization System(CECS))the Materials/Parts Technology Development Program(No.RS-2024-00456324)funded by the Ministry of Trade,Industry&Energy(MOTIE,Korea).
摘要As demand for lithium-ion batteries increases,the supply of materials is increasingly constrained by their geographical concentration.This has spurred significant research into recycling spent batteries to enhance resource circulation.Currently,commercially applied recycling methods(such as pyrometallurgy and hydrometallurgy)face environmental and economic challenges,including waste acid and gas generation,high-temperature heat treatment,and operational complexity.A promising alternative is the carbothermic reduction process,which operates at lower temperatures,minimizing costs and environmental emissions.However,this method still requires large quantities of external reducing agents.Therefore,this study aims to introduce a simplified direct carbothermic reduction(SDCR)process.The SDCR process leveraged carbon conductive materials and organic binders within the electrode as reducing agents.Additionally,the high compaction state created a conducive environment for reducing gases,promoting efficient reduction and material recovery.This approach reduces the reliance on external reducing agents and streamlines the re-upcycling process,making it commercially viable.
基金supported by the Natural Science Foundation of Shandong Province(ZR2021QH096,ZR2020MH024)the National Natural Science Foundation of China(82300354,882070345)+2 种基金the Academic Promotion Program of Shandong First Medical University(2019QL012)the Shandong Taishan Scholarship(to SHY)fund of Tianjin Zhongxin Pharmaceutical Group Co.,Ltd。
摘要Acute myocardial infarction(AMI)is a leading cause of death and disability worldwide and consists of two distinct cardiac pathologies:ST-elevation myocardial infarction(STEMI)and non-ST-elevation myocardial infarction(NSTEMI).[1]In China,AMI is widely recognized as a predominant cause of mortality in both urban and rural demographics,based on the 2022 Report on Cardiovascular Health and Diseases in China;moreover,its mortality rate has been reported to be rising,with a recurrence rate of 2.5%within one year.
摘要Background: Early research describing the concept of intensity-modulated conformal radiotherapy (IMRT) was based on 7 to 9 beams to reach an adequate level of modulation. Nevertheless, its implementation demands significant resources. Our objective was to compare the compliance and homogeneity of target dose distribution between simplified IMRT and 3D-CRT in patients with cervical cancer and to assess the clinical value of simplified IMRT. Materials and Methods: From 2016 to 2017, 17 patients with stage IIB - IIIC cervical cancer were treated with external beam radiotherapy using simplified IMRT (12 cases) or 3DCRT (05 cases) and brachytherapy. Prior to radiotherapy, CT scans were conducted to delineate the target volume. The clinical target volume (CTV) included the uterus, primary tumor, supravaginal portion of the cervix, paracervical tissue, common iliac, internal and external iliac lymph nodes, obturator, and pre sacral lymph nodes, and the surrounding tissues. If the lower vagina was involved, the target volume included the whole vagina. The planning target volume (PTV) included the CTV with 1 cm anteriorly and 0.5 cm in all other directions. The PTV received 95% of 45 Gy (1.8 Gy/25 fraction). Dose-volume histogram, conformity index, homogeneity index, and treatment time per fraction were compared. Results: The 3D-CRT plan was more homogeneous than the simplified IMRT plan, while the simplified IMRT plan was more conformal. The volume of small bowels that received high-dose radiation significantly increased with simplified IMRT compared to 3D-CRT. Treatment time per fraction was 6 and 13 minutes for 3D-CRT and simplified IMRT, respectively. Conclusion: The simplified IMRT treatment plan is technically and dosimetrically acceptable and an alternative to the classic 3D-CRT plan for cervical cancer. It provides better dose distribution than 3D-CRT. However, the 3D-CRT treatment plan significantly reduced the overall treatment time per fraction.
基金Project(2011CB013605)supported by the National Basic Research Development Program of China(973 Program)Projects(51178071,51008041)supported by the National Natural Science Foundation of ChinaProject(NCET-12-0751)supported by the New Century Excellent Talents Program in University of Ministry of Education of China
摘要In order to study the differences in vertical component between onshore and offshore motions,the vertical-to-horizontal peak ground acceleration ratio(V/H PGA ratio) and vertical-to-horizontal response spectral ratio(V/H) were investigated using the ground motion recordings from the K-NET network and the seafloor earthquake measuring system(SEMS).The results indicate that the vertical component of offshore motions is lower than that of onshore motions.The V/H PGA ratio of acceleration time histories at offshore stations is about 50%of the ratio at onshore stations.The V/H for offshore ground motions is lower than that for onshore motions,especially for periods less than 0.8 s.Furthermore,based on the results in statistical analysis for offshore recordings in the K-NET,the simplified V/H design equations for offshore motions in minor and moderate earthquakes are proposed for seismic analysis of offshore structures.
摘要AIM To simplify the diagnostic criteria for superficial esophageal squamous cell carcinoma(SESCC) on Narrow Band Imaging combined with magnifying endoscopy(NBI-ME).METHODS This study was based on the post-hoc analysis of a randomized controlled trial. We performed NBI-ME for 147 patients with present or a history of squamous cell carcinoma in the head and neck, or esophagus between January 2009 and June 2011. Two expert endoscopistsdetected 89 lesions that were suspicious for SESCC lesions, which had been prospectively evaluated for the following 6 NBI-ME findings in real time: "intervascular background coloration"; "proliferation of intrapapillary capillary loops(IPCL)"; and "dilation", "tortuosity", "change in caliber", and "various shapes(VS)" of IPCLs(i.e., Inoue's tetrad criteria). The histologic examination of specimens was defined as the gold standard for diagnosis. A stepwise logistic regression analysis was used to identify candidates for the simplified criteria from among the 6 NBI-ME findings for diagnosing SESCCs. We evaluated diagnostic performance of the simplified criteria compared with that of Inoue's criteria.RESULTS Fifty-four lesions(65%) were histologically diagnosed as SESCCs and the others as low-grade intraepithelial neoplasia or inflammation. In the univariate analysis, proliferation, tortuosity, change in caliber, and VS were significantly associated with SESCC(P < 0.01). The combination of VS and proliferation was statistically extracted from the 6 NBI-ME findings by using the stepwise logistic regression model. We defined the combination of VS and proliferation as simplified dyad criteria for SESCC. The areas under the curve of the simplified dyad criteria and Inoue's tetrad criteria were 0.70 and 0.73, respectively. No significant difference was shown between them. The sensitivity, specificity, and accuracy of diagnosis for SESCC were 77.8%, 57.1%, 69.7% and 51.9%, 80.0%, 62.9% for the simplified dyad criteria and Inoue's tetrad criteria, respectively.CONCLUSION The combination of proliferation and VS may serve as simplified criteria for the diagnosis of SESCC using NBIME.
基金supported by the National Natural Science Foundation of China(Grant No.61372046)the Research Fund for the Doctoral Program of Higher Education of China(New Teachers)(Grant No.20116101120018)+6 种基金the China Postdoctoral Science Foundation Funded Project(Grant Nos.2011M501467 and 2012T50814)the Natural Science Basic Research Plan in Shaanxi Province of China(Grant No.2011JQ1006)the Fundamental Research Funds for the Central Universities(Grant No.GK201302007)Science and Technology Plan Program,in Shaanxi Province of China(Grant Nos.2012 KJXX-29 and 2013K12-20-12)the Science and Technology Plan Program in Xian of China(Grant No.CXY1348(2))the.GraduateInovation Project of Northwest University(Grant No.YZZ12093)the Seience and Technology Program of Educational Committee,of Shaanxi Province of China(Grant No.12JK0729).
摘要Recently,the simplified spherical harmonics equations(SP)model has at tracted much att entionin modeling the light propagation in small tissue ggeometriesat visible and near-infrared wave-leng ths.In this paper,we report an eficient numerical method for fluorescence moleeular tom-ography(FMT)that combines the advantage of SP model and adaptive hp finite elementmethod(hp-FEM).For purposes of comparison,hp-FEM and h-FEM are,respectively applied tothe reconstruction pro cess with diffusion approximation and SPs model.Simulation experiments on a 3D digital mouse atlas and physical experiments on a phantom are designed to evaluate thereconstruction methods in terms of the location and the reconstructed fluorescent yield.Theexperimental results demonstrate that hp-FEM with SPy model,yield more accurate results thanh-FEM with difusion approximation model does.The phantom experiments show the potentialand feasibility of the proposed approach in FMT applications.
基金financially supported by the National Natural Science Foundation of China(Grant No.11372184)the National Basic Research Program of China(973 Program,Grant Nos.2015CB251203-3 and 2013CB036103)
摘要Scale effect of ISWs loads on Floating Production Storage and Offloading(FPSO) is studied in this paper. The application conditions of KdV, eKdV and MCC ISWs theories are used in the numerical method. The depthaveraged velocities induced by ISWs are used for the velocity-inlet boundary. Three scale ratio numerical models λ=1, 20 and 300 were selected, which the scale ratio is the size ratio of numerical models to the experimental model.The comparisons between the numerical and former experimental results are performed to verify the feasibility of numerical method. The comparisons between the numerical and simplified theoretical results are performed to discuss the applicability of the simplified theoretical model summarized from the load experiments. Firstly, the numerical results of λ=1 numerical model showed a good agreement with former experimental and simplified theoretical results. It is feasible to simulate the ISWs loads on FPSO by the numerical method. Secondly, the comparisons between the results of three scale ratio numerical models and experimental results indicated that the scale ratios have more significant influence on the experimental horizontal forces than the vertical forces. The scale effect of horizontal forces mainly results from the different viscosity effects associated with the model’s dimension.Finally, through the comparisons between the numerical and simplified theoretical results for three scale ratio models, the simplified theoretical model of the pressure difference and friction forces exerted by ISWs on FPSO is applied for large-scale or full-scale FPSO.
基金The work described in this paper was jointly supported by the National Natural Science Foundation of China (51478360, 51323013, and 50978204).
摘要Wind-tunnel tests of a large-scale sectional model with synchronous measurements of force and vibration responses were carried out to investigate the nonlinear behaviors of vertical vortex-induced forces (VIFs) on three typical box decks (i.e., fully closed box, centrally slotted box, and semi-closed box). The mechanisms of the onset, development, and self-limiting phenomenon of the vertical vortex-induced vibration (VlV) were also explored by analyzing the energy evolution of different vertical VIF components and their contributions to the vertical VIV responses. The results show that the nonlinear components of the vertical VIF often differ from deck to deck; the most important components of the vertical VIF, governing the stable amplitudes of the vertical VIV responses, are the linear and cubic components of velocity contained in the self-excited aerodynamic damping forces. The former provides a constant negative damping ratio to the vibration system and is thus the essential power driving the development of the VIV amplitude, while the latter provides a positive damping ratio proportional to the square of the vibration velocity and is actually the inherent factor making the VIV amplitude self-limiting. On these bases, a universal simplified nonlinear mathematical model of the vertical VIF on box decks of bridges is presented and verified in this paper; it can be used to predict the stable amplitudes of the vertical VIV of long-span bridges with satisfactory accuracy.
基金Supported by the National Natural Science Foundation of China under Grant Nos 91024026,10975126,70871082 and 70971089the Specialized Research Fund for the Doctoral Program of Higher Education of China under Grant No 20093402110032the Research Foundation of Hebei Educational Committee under Grant No Z2009139.
摘要We propose a simplified human regular mobility model to simulate an individual's daily travel with three sequential activities:commuting to workplace,going to do leisure activities and returning home.With the assumption that the individual has a constant travel speed and inferior limit of time at home and in work,we prove that the daily moving area of an individual is an ellipse,and finally obtain an exact solution of the gyration radius.The analytical solution captures the empirical observation well.
基金National Natural Science Foundation of China under Grant Nos.51678302 and 51678301Jiangsu Province Industry-University-Research Joint Innovation Fund--Prospective Joint Research Project under Grant No.BY2014005-05Major Program of Natural Science Foundation of the Jiangsu Higher Education Institutions of China under Grant No.14KJA560001
摘要In this study, simplified numerical models are developed to analyze the soil-structure interaction (SSI) effect on frame structures equipped with viscoelastic dampers (VEDs) based on pile group foundation. First, a single degree-of- freedom (SDOF) oscillator is successfully utilized to replace the SDOF energy dissipated structure considering the SSI effect. The equivalent period and damping ratio of the system are obtained through analogical analysis using the frequency transfer function with adoption of the modal strain energy (MSE) technique. Aparametric analysis is carried out to study the SSI effect on the performance of VEDs. Then the equilibrium equations of the multi degree-of-freedom (MDOF) structure with VEDs considering SSI effect are established in the frequency domain. Based on the assumption that the superstructure of the coupled system possesses the classical normal mode, the MDOF superstructure is decoupled to a set of individual SDOF systems resting on a rigid foundation with adoption of the MSE technique through formula derivation. Numerical results demonstrate that the proposed methods have the advantage of reducing computational cost, however, retaining the satisfactory accuracy. The numerical method proposed herein can provide a fast evaluation of the efficiency of VEDs considering the SSI effect.
基金National Natural Science Foundation of China under Grants Nos.51208268 and 51178429K.C.Wong Magna Fund in Ningbo University+1 种基金Transportation Science and Technology Project of Ningbo City under Grant No.201507Natural Science Foundation of Ningbo City under Grant No.2015A610293
摘要In recent years, precast segmental concrete bridge columns became prevalent because of the benefits of accelerated construction, low environmental impact, high quality and low life cycle costs. The lack of a detailed configuration and appropriate design procedure to ensure a comparable performance with monolithic construction has impeded this structural system from being widely used in areas of high seismicity. In this study, precast segmental bridge column cyclic loading tests were conducted to investigate the performance of unbonded post-tensioned segmental bridge columns. One monolithic and two precast segmental columns were tested. The preeast segmental column exhibited minor damage and small residual displacement after the maximum 7% cyclic drift; energy dissipation (ED) can be enhanced byadding ED bars. The experimental results were modeled by a simplified pushover method (SPOM), as well as a fiber model (FIBM) finite element method. Forty-five cases of columns with different aspect ratios, axial load ratios and ED bar ratios were analyzed with the SPOM and FIBM, respectively. Using these parametric results, a simplified design method was suggested by regressive analysis. Satisfactory correlation was found between the experimental results and the simplified design method for preeast segmental columns with different design parameters.
基金Supported by the National Natural Science Foundation of China under Grant Nos 60925022 and 10804097the National HighTech Research and Development Program of China under Grant No 2006AA06A204+4 种基金the Research Fund for the Doctoral Program of Higher Education of China(20090101120009)the Zhejiang Provincial Qian-Jiang-Ren-Cai Project of China(2009R10034)the Fundamental Research Funds for the Central Universities(2010QNA3024)the Open Fund of the State Key Laboratory of High Field Laser Physics(Shanghai Institute of Optics and Fine Mechanics)the Open Fund of the State Key Laboratory of Precision Spectroscopy(East China Normal University).
摘要A simplified two-dimensional(2-D)magneto-optical trap(MOT)for loading atoms into a 3-D MOT is realized.Instead of utilizing multiple wave plates and beam splitters to cover a large cooling region,we deploy cooling beams with elliptical cross-section profiles to achieve a comparable cooling volume.This simplification reduces the cost and difficulty of alignment.The 3-D MOT achieves a loading rate of 2×108 atoms per second via this simplified 2-D MOT.Correlation between the loading rate and parameters of optical system is also determined.
基金supported by National Natural Science Foundation of China(Nos.51377038,51307030)
摘要Evaporation erosion of the contacts is one of the fundamental failure mechanisms for relays. In this paper, the evaporation erosion characteristics are investigated for the copper contact pair breaking a resistive direct current (dc) 30 V/10 A circuit in the air. Molten pool simulation of the contacts is coupled with the gas dynamics to calculate the evaporation rate. A simplified arc model is constructed to obtain the contact voltage and current variations with time for the prediction of the current density and the heat flux distributions flowing from the arc into the contacts. The evaporation rate and mass variations with time during the breaking process are presented. Experiments are carried out to verify the simulation results.
基金National Key Research and Development Program of China under Grant No.2011CB013606The financial support from the National Natural Science Foundation of China under Grant No.51378343。
摘要The aseismic design of cable-stayed bridges in the transverse direction with newly proposed metallic dampers that can accommodate both longitudinal and transverse movement of the deck has recently been considered.This work focuses on developing a simplified method to design an appropriate metallic damper.The seismic performance of cablestayed bridges with different damper stiffness,main span lengths,tower shapes and types of deck in the transverse direction are investigated.The transverse displacement of the deck of a cable-stayed bridge increases significantly with the increment of the damper stiffness,which proves that the design of the damper stiffness is crucial.A simplified model considering the damper stiffness,cable system and tower in the transverse direction is developed to evaluate the period and lateral displacement of a complicated cable-stayed bridge.Based on the simplified model,a design method is proposed and assessed using two cable-stayed bridges as examples.The results show that metallic dampers can be designed with high efficiency,and the optimal ductility of the damper can be selected.
摘要Professionalism is crucial in all professions and is particularly important in the medical field.Measuring students' perceptions of professionalism can help to form education targeting the enhancement of professionalism.This study aimed to validate an effective assessment tool for the measurement of medical students5 perceptions of medical professionalism in China's Mainland.The cross-sectional survey was conducted in three medical colleges in Guangdong,China.Of the 2103 eligible medical students,1976 responded,and 1856 questionnaires were deemed valid.Students from clinical medicine in these three medical colleges were randomly selected by cluster sampling.First,a Simplified Chinese Version questionnaire to measure Student's Perception of Medical Professionalism (SCV-SPMP) was constructed.Second,questionnaires from 1856 students majoring in clinical medicine at three medical colleges were included in the analysis.Third,exploratory factor analysis,Cronbach's alpha,item-subscale correlation,and confirmatory factor analysis were conducted to test the validity and reliability of the SCV-SPMP.Nine items were eliminated following exploratory factor analysis,and four subscales were extracted from the analysis.All internal consistency reliability exceeded the minimum standard.The overall Cronbach's alpha was 0.94,and four subscales' alphas were 0.82 (Accountability and excellence),0.81 (Duty),0.89 (Honor and integrity),and 0.85 (Practice habits and respect for others),respectively.The model fit was good.The convergent validity and discriminant validity were acceptable.The modified SCVSPMP was found to be a valid and reliable tool to capture the main features of Chinese students' perceptions of medical professionalism in four dimensions,and it provides a quantitative method for the measurement of the students' perceptions in China's Mainland..
基金Project(52109132)supported by the National Natural Science Foundation of ChinaProject(ZR2020QE270)supported by the Natural Science Foundation of Shandong Province,China+1 种基金Project(JMDPC202204)supported by State Key Laboratory of Strata Intelligent Control,Green Mining Co-founded by Shandong Province and the Ministry of Science and TechnologyShandong University of Science and Technology,China。
摘要Toppling failure of rock mass/soil slope is an important geological and environmental problem.Clarifying its failure mechanism under different conditions has great significance in engineering.The toppling failure of a cutting slope occurred in a hydropower station in Kyushu,Japan illustrates that the joint characteristic played a significant role in the occurrence of rock slope tipping failure.Thus,in order to consider the mechanical properties of jointed rock mass and the influence of geometric conditions,a simplified analytical approach based on the limit equilibrium method for modeling the flexural toppling of cut rock slopes is proposed to consider the influence of the mechanical properties and geometry condition of jointed rock mass.The theoretical solution is compared with the numerical solution taking Kyushu Hydropower Station in Japan as one case,and it is found that the theoretical solution obtained by the simplified analysis method is consistent with the numerical analytical solution,thus verifying the accuracy of the simplified method.Meanwhile,the Goodman-Bray approach conventionally used in engineering practice is improved according to the analytical results.The results show that the allowable slope angle may be obtained by the improved Goodman-Bray approach considering the joint spacing,the joint frictional angle and the tensile strength of rock mass together.
摘要A simple control structure in servo system is occasionally needed for simple industrial application which precise and high control performance is not exessively important so that the cost production can be reduced efficiently. Simplified vector control, which has simple control structure, is utilized as the permanent magnet synchronous motor control algorithm and genetic algorithm is used to tune three PI controllers used in simplified vector control. The control performance is obtained from simulation and investigated to verify the feasibility of the algorithm to be applied in the real application. Simulation results show that the speed and torque responses of the system in both continuous time and discrete time can achieve good performances. Furthermore, simplified vector control combined with genetic algorithm has a similar perfofmance with conventional field oriented control algorithm and possible to be realized into the real simple application in the future.